Haemophagocytic lymphohistiocytosis

D3_HAEMOPHAGOLYMPHO

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D76.1 Cause of death: ICD-10 — D76.1 2 out of 7 registries used, show all original rules.	46
4. Check minimum number of events None	46
5. Include endpoints None	46
6. Filter based on genotype QC (FinnGen only)	46

Control definitions (FinnGen only)

Control exclude: D3_BLOODOTHER

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D76
Name in latin: Lymphohistiocytosis haemophagocytica

NAME	D3_HAEMOPHAGOLYMPHO
CONTROL_EXCLUDE	D3_BLOODOTHER
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D761
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D761
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Haemophagocytic lymphohistiocytosis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	229	104	124
Only index persons	190	85	105
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	53.33	53.45	53.32
Only index persons	60.41	60.93	59.99

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	46	19	27
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	58.45	54.69	61.10

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

44.53

34.49

2.5

1.5

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

37.80

29.39

4.5

1.4

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

34.62

27.33

3.8

1.1

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

31.36

27.23

2.3

2.2

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

31.67

25.31

1.5

1.3

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

31.67

25.31

1.6

1.3

—

(4035726)

19.32

23.63

3.2

1.2

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

18.17

21.56

3.7

1.5

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

26.38

21.37

1.8

1.9

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

20.88

20.75

10.7

2.0

83.9

90.2

0.29

(3021879) Hepatitis B virus core Ab [Presence] in Serum

15.95

19.36

2.1

1.6

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

18.34

19.28

4.5

1.6

2.1

0.3

ug/l

0.85

(3017143) Hepatitis C virus Ab [Presence] in Serum

14.14

19.10

2.3

1.6

—

(3004588) Protein electrophoresis panel - Serum or Plasma

15.96

18.87

2.3

1.1

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

13.67

18.65

2.5

1.6

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

19.91

17.72

2.0

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

19.91

17.72

2.4

1.9

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

19.91

17.72

2.0

1.5

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

21.77

17.57

1.7

1.2

—

(3020779) Urea [Moles/volume] in Serum or Plasma

13.38

17.46

11.9

14.4

13.1

9.6

mmol/l

0.84

(3009445) Proteinase 3 Ab [Units/volume] in Serum

17.39

17.23

1.8

1.1

—

(3037522) Nuclear Ab [Titer] in Serum

11.99

16.65

2.2

1.3

672.0

330.7

titre

—

(3015479) Mycobacterium sp identified in Blood by Organism specific culture

+∞

16.65

2.3

0.0

—

(3023368) Bacteria identified in Blood by Culture

104

18.93

16.26

26.9

5.0

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

11.71

16.03

18.4

5.6

0.8

mmol/l

1.03

(46235355) HIV 1 and 2 tests - Meaningful Use set

11.37

15.94

3.0

2.0

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

38.94

15.37

4.5

1.0

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

47.58

15.30

1.8

1.2

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

40.74

14.77

1.4

1.3

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

52.09

14.76

3.9

3.0

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

10.37

14.75

5.3

1.5

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

35.61

14.29

1.4

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

10.12

14.02

9.3

1.8

4.3

1.3

mg/l

1.48

(3010130) Cytomegalovirus IgG Ab [Units/volume] in Serum or Plasma

37.18

13.70

1.5

1.3

93.2

—

u/ml

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

9.63

13.13

3.3

1.5

—

(3015171) Extractable nuclear Ab [Units/volume] in Serum

28.85

12.79

1.4

1.3

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

43.18

12.59

1.7

2.4

—

(42870588) Differential panel, method unspecified - Blood

118

10.43

12.30

39.1

5.5

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

35.92

12.07

2.4

1.0

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

145

12.04

11.74

21.2

2.9

3701.8

115.4

ug/l

3.88

133

(3004789) Transferrin [Mass/volume] in Serum or Plasma

8.09

11.62

2.6

3.1

1.9

2.4

g/l

2.36

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

30.73

11.60

2.2

1.0

—

(3042936) Bacteria identified in Isolate by Culture

7.94

11.40

2.3

2.7

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

8.36

11.34

3.6

1.4

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

26.87

11.17

1.7

1.3

—

(3022948) Iron [Moles/volume] in Serum or Plasma

7.64

10.98

2.7

3.0

13.9

13.1

umol/l

0.14

(3019832) Treponema pallidum Ab [Presence] in Serum

9.69

10.98

2.9

1.8

—

(3026493) Urate [Moles/volume] in Serum or Plasma

109

8.17

10.81

7.6

2.8

300.6

8331.1

umol/l

0.80

(3044640) Blood type and Crossmatch panel - Blood

118

8.21

10.50

13.9

2.3

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

35.18

10.49

2.5

1.2

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

12.83

9.94

13.4

2.5

217.5

204.6

0.11

(3017962) TCRG gene rearrangements [Presence] in Blood or Tissue by Molecular genetics method

+∞

9.70

1.4

0.0

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

+∞

9.70

1.6

0.0

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

+∞

9.70

1.2

0.0

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

6.67

9.37

2.7

3.2

30.4

22.0

1.02

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

10.47

9.31

2.8

1.0

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

21.92

9.20

1.9

1.3

11.5

8.4

mg/l

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

26.26

9.03

1.3

1.0

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

19.45

8.84

1.8

1.2

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

19.45

8.84

2.2

1.6

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

+∞

8.59

1.6

0.0

—

(3037756) Immunofixation for Serum or Plasma

28.11

8.48

1.5

1.2

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

6.33

8.23

6.8

4.1

21.2

11.5

umol/l

0.82

(3016650) Hepatitis A virus Ab [Presence] in Serum

20.04

7.67

1.2

1.0

—

(3000494) Fungus identified in Specimen by Culture

5.90

7.63

2.7

2.0

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

196

7.48

7.51

35.8

9.6

1.2

mmol/l

0.01

166

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

+∞

7.48

1.1

0.0

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

17.73

6.75

1.8

1.3

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

17.73

6.75

1.3

1.4

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

173

5.97

6.66

18.4

4.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

4.88

6.62

12.9

2.3

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

21.80

6.55

1.2

1.0

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

21.80

6.55

1.2

—

(3007853) Bacteria identified in Skin by Aerobe culture

5.41

6.52

1.6

1.4

—

(3024471) HLA-A [Type]

+∞

6.38

1.0

0.0

—

(3048879) Bone marrow aspiration report

+∞

6.38

1.7

0.0

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

+∞

6.38

1.7

0.0

—

(21491868) Cryoglobulin [Mass/volume] in Serum

+∞

6.38

1.3

0.0

—

g/l

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

+∞

6.38

1.7

0.0

—

(3014007) Fractional oxyhemoglobin in Arterial blood

7.71

6.24

5.6

13.2

95.1

94.1

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

18.15

6.19

8.0

4.3

—

(3034770) Mitochondria Ab [Titer] in Serum

15.54

5.86

1.2

1.4

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

106

4.34

5.70

5.7

3.3

1565.6

967.8

ng/l

0.77

(40768806) Pleura Pathology biopsy report

18.88

5.63

1.0

2.6

—

(3044290) Cell count panel - Cerebral spinal fluid

18.88

5.63

1.4

1.6

—

(3033658) Prothrombin time (PT) actual/Normal

4.30

5.62

22.5

4.5

84.8

90.1

0.52

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

147

4.40

5.45

6.7

3.8

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

+∞

5.30

1.8

0.0

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

+∞

5.30

1.0

0.0

—

(3024932) HLA-DR beta [Type]

+∞

5.30

2.0

0.0

—

(3013862) HLA-DP [Type]

+∞

5.30

1.0

0.0

—

(40760410) HLA-B [Type] by High resolution

+∞

5.30

1.0

0.0

—

(40765096) Chromosome analysis panel by Banding

+∞

5.30

1.2

0.0

—

(46236302) HLA-C [Type] by High resolution typing

+∞

5.30

1.0

0.0

—

(40760409) HLA-A [Type] by High resolution

+∞

5.30

1.0

0.0

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

+∞

5.30

1.8

0.0

—

(40763590) HLA-DQ beta [Type]

+∞

5.30

1.0

0.0

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

15.72

5.29

1.8

1.2

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

12.06

5.29

2.2

1.8

—

(40760892) CBC W Ordered Manual Differential panel - Blood

4.05

5.15

19.7

4.7

—

(3022313) Gas panel - Capillary blood

5.71

5.09

7.8

4.1

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

10.83

5.04

1.2

1.1

—

(3032080) INR in Blood by Coagulation assay

146

4.03

4.93

15.0

8.6

1.1

1.2

inr

—

(3018418) pH of Serum or Plasma

108

3.88

4.88

21.3

4.1

7.4

—

(3003694) ABO and Rh group [Type] in Blood

3.89

4.87

2.7

1.3

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

9.83

4.81

3.2

1.0

0.1

0.0

g/l

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

16.13

4.74

1.9

1.0

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

16.13

4.74

1.9

1.0

—

(40761536) Microorganisms panel - Urine sediment

5.25

4.65

9.4

6.1

—

(40768804) Tissue Pathology biopsy report

127

3.73

4.58

2.7

2.0

—

(3031040) Bacteria [#/volume] in Urine by Automated count

246

4.83

4.49

7.4

4.4

—

12.3

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

10.44

4.48

1.5

1.6

419.5

538.0

mg/l

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

5.28

4.33

8.0

4.2

25.6

23.8

mmol/l

—

(3026008) Bacteria identified in Urine by Culture

108

3.56

4.29

4.3

3.0

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

9.39

4.25

3.1

1.0

0.0

g/l

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

9.39

4.25

3.1

1.0

0.0

g/l

—

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

11.49

4.16

1.6

1.1

3.7

3.6

mmol/l

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

4.25

4.12

4.5

20.7

4.2

5.1

kpa

3.68

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

7.16

4.04

2.8

1.3

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

13.49

3.87

1.5

1.2

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

13.49

3.87

1.5

1.2

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

13.49

3.87

1.7

2.2

—

(3010421) pH of Blood

8.91

3.70

5.6

7.6

7.4

—

(3013290) Carbon dioxide [Partial pressure] in Blood

8.91

3.70

5.6

7.3

4.5

5.0

kpa

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

8.91

3.70

2.9

1.2

—

(3027315) Oxygen [Partial pressure] in Blood

8.91

3.70

5.6

7.3

8.5

8.9

kpa

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

4.20

3.59

31.3

8.4

23.1

24.9

mmol/l

0.89

(3000991) Gas panel - Venous blood

3.81

3.37

8.5

9.3

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

7.27

3.32

1.1

1.2

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

7.27

3.32

1.1

1.6

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

5.06

3.19

3.7

1.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

3.82

3.17

8.8

2.7

—

(3013512) EKG study

109

2.95

3.15

6.6

4.2

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

10.98

3.05

7.2

3.8

51.8

60.6

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

10.98

3.05

1.0

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

6.13

2.99

7.7

1.9

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

6.13

2.99

1.4

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

136

2.84

2.98

3.2

3.4

2.2

2.3

mmol/l

2.03

116

(36304419) Bacteria [Presence] in Urine

112

2.85

2.96

7.0

3.7

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

2.96

2.88

1.4

1.2

60.5

29.3

iu/ml

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

9.14

2.82

1.8

1.0

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

9.14

2.82

1.8

2.3

—

(3029937) Albumin [Presence] in Urine by Test strip

2.80

2.81

8.0

4.1

0.0

estimate

0.00

(1616796) Gas panel - Central venous blood

6.70

2.79

2.7

9.0

—

(3019060) Gas panel - Arterial blood

4.04

2.65

2.6

21.6

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

7.83

2.61

5.0

3.7

—

(3002032) Base excess in Venous blood by calculation

3.18

2.60

35.8

5.2

1.0

1.9

mmol/l

0.47

(3025941) Bacteria identified in Stool by Culture

4.38

2.60

1.9

1.2

—

(3019225) pH of Specimen

3.74

2.46

16.3

3.9

—

(3035350) Ketones [Presence] in Urine by Test strip

192

2.62

2.43

8.2

3.9

0.0

estimate

0.00

(3021601) Nitrite [Presence] in Urine by Test strip

192

2.62

2.43

11.3

5.6

0.0

estimate

0.00

(3012544) pH of Venous blood

3.03

2.42

35.8

5.5

—

(3009261) Glucose [Presence] in Urine by Test strip

193

2.59

2.39

8.4

4.0

0.0

estimate

0.00

(3020891) Body temperature

5.13

2.35

4.3

4.0

—

(3015736) pH of Urine

147

2.32

2.03

6.4

3.6

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

3.89

1.90

27.2

4.9

30.8

55.3

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

3.40

1.88

51.3

4.3

115.6

128.7

g/l

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

2.44

1.83

1.2

53.3

3.0

u/ml

—

(40758558) Short blood count panel - Blood

101

2.29

1.83

47.9

5.8

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

3.67

1.81

15.3

3.7

25.7

24.5

mmol/l

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

110

2.24

1.79

2.8

2.0

63.3

173.5

u/l

2.29

102

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

174

2.14

1.69

3.3

2.7

76.2

71.9

nmol/l

0.49

158

(21494755) Public health laboratory ask at order entry panel

0.00

1.60

0.0

1.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

149

2.09

1.60

8.5

4.1

—

(3022145) Colonoscopy Study observation

2.55

1.50

1.2

1.3

—

(3002256) Pathology report gross observation

2.55

1.50

1.6

1.2

—

(40768797) Stomach Pathology biopsy report

2.36

1.47

1.5

1.4

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

2.18

1.45

3.9

3.6

2.4

2.5

mmol/l

0.32

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

2.12

1.32

5.4

3.2

54.8

122.0

ng/l

0.42

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

2.40

1.29

1.9

2.8

20.8

28.7

u/l

—

(40761535) Cells panel - Urine sediment

2.60

1.29

3.8

3.1

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

371

0.50

1.27

4.9

5.8

38.2

39.9

mmol/mol

0.29

348

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

290

2.11

1.23

3.6

3.7

14.4

14.9

pmol/l

0.59

255

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

353

2.48

1.21

4.1

4.4

1.8

1.9

mu/l

0.32

317

(3037121) Protein [Mass/volume] in Urine

2.68

1.18

1.8

5.4

0.2

0.1

g/l

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.68

1.18

55.6

2.9

0.7

—

(3000330) Specific gravity of Urine by Test strip

2.68

1.18

7.4

6.0

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.54

1.12

55.6

2.9

1.2

1.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

113

1.80

1.01

9.1

4.2

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

1.69

0.73

2.2

1.7

553.1

486.6

pmol/l

0.22

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.88

0.68

4.8

3.7

0.5

0.1

e6/l

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.60

0.61

6.8

2.9

—

(3044889) 12 lead EKG panel

277

1.51

0.55

6.6

3.4

—

(3003338) MCHC [Mass/volume]

355

0.68

0.48

80.1

17.6

331.3

334.2

g/l

0.88

355

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.42

0.0

1.7

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

1.6

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.47

0.38

1.7

1.6

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.49

0.37

1.5

1.6

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.42

0.36

19.5

6.9

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.4

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.21

0.0

2.9

—

(4094501)

0.00

0.21

0.0

1.2

—

(3009542) Hematocrit [Volume Fraction] of Blood

374

1.28

0.16

63.1

15.3

29.9

40.5

3.39

288

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

1.18

0.10

2.2

4.8

21.0

29.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

248

1.11

0.07

4.4

3.0

—

(1761868) Lipid panel - Serum or Plasma

156

0.94

0.01

3.3

2.8

—

(40761511) CBC panel - Blood by Automated count

409

1.02

0.00

58.1

13.6

—

(1002224) Polysomnography panel

0.00

0.0

1.1

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.0

—

(3000034) Microalbumin [Mass/volume] in Urine

0.00

0.0

3.8

—

31.9

—

(3040151) Glucose [Moles/volume] in Capillary blood

0.00

0.0

19.7

—

6.8

—

(4146454)

0.00

0.0

2.6

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.0

1.9

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

1.0

—

97.0

—

(42870365) C reactive protein [Mass/volume] in Blood by High sensitivity method

0.00

0.0

2.2

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint D3_HAEMOPHAGOLYMPHO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have D3_HAEMOPHAGOLYMPHO.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: D3_HAEMOPHAGOLYMPHO – Haemophagocytic lymphohistiocytosis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Haemophagocytic lymphohistiocytosis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints