hematologic disease: A disease involving the hematopoietic system.
Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue
DOID EFO Endpoint Browser PheWeb
D3_OTHDISLYMPHORETANDRETICULOHIST
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
118 |
4. Check minimum number of eventsNone |
118 |
5. Include endpoints |
118 |
6. Filter based on genotype QC (FinnGen only) |
118 |
Control definitions (FinnGen only)
- Control exclude
- D3_BLOODOTHER
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D70-D77
- Name in latin
- Aliqui morbi textus lymphoreticularis et systematis reticulohistiocytici
Similar endpoints
↥List of similar endpoints to Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue based on the number of shared cases.
Similar with more cases:
- Other diseases of blood and blood-forming organs, wide
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 896 | 420 | 473 |
Only index persons | 719 | 332 | 387 |
Unadjusted period prevalence (%) | |||
Whole population | 0.01 | 0.01 | 0.01 |
Only index persons | 0.01 | 0.01 | 0.01 |
Median age at first event (years) | |||
Whole population | 34.32 | 35.37 | 33.34 |
Only index persons | 41.02 | 42.89 | 39.42 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 118 | 55 | 63 |
Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.03 |
Median age at first event (years) | 52.10 | 52.89 | 51.41 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 104
- Matched controls
- 1041
LabWAS
↥Mortality – FinRegistry
↥Association
Association between endpoint D3_OTHDISLYMPHORETANDRETICULOHIST and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
D3_OTHDISLYMPHORETANDRETICULOHIST | 4.294 [2.6, 7.1] | < 0.001 |
Birth year | 0.998 [0.99, 1.01] | 0.683 |
During the follow-up period (1.1.1998 — 31.12.2019), 66 out of 345 females with D3_OTHDISLYMPHORETANDRETICULOHIST died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
D3_OTHDISLYMPHORETANDRETICULOHIST | 3.517 [2.18, 5.68] | < 0.001 |
Birth year | 0.99 [0.98, 1.0] | 0.029 |
During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 367 males with D3_OTHDISLYMPHORETANDRETICULOHIST died.
Mortality risk
Mortality risk for people of age
years, who have D3_OTHDISLYMPHORETANDRETICULOHIST.N-year risk | Females | Males |
---|---|---|
1 | 0.342% | 0.823% |
5 | 2.472% | 4.244% |
10 | 5.771% | 10.339% |
15 | 11.403% | 19.136% |
20 | 20.89% | 30.915% |
Relationships between endpoints
↥Index endpoint: D3_OTHDISLYMPHORETANDRETICULOHIST – Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue
GWS hits: -