Other degenerative disorders of eyelid and periocular area

H7_EYELIDDEGEN

eyelid disease: A disease involving the eyelid.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H02.7 Hospital discharge: ICD-9 — 3745 Cause of death: ICD-10 — H02.7 Cause of death: ICD-9 — 3745 2 out of 7 registries used, show all original rules.	102
4. Check minimum number of events None	102
5. Include endpoints None	102
6. Filter based on genotype QC (FinnGen only)	98

Control definitions (FinnGen only)

Control exclude: H7_LIDLACRIMALORBIT

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H02
Name in latin: Aliae morbositates degenerativae palpebrarum et areae periocularis

NAME	H7_EYELIDDEGEN
CONTROL_EXCLUDE	H7_LIDLACRIMALORBIT
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H027
HD_ICD_9	3745
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H027
COD_ICD_9	3745
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other degenerative disorders of eyelid and periocular area based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	546	357	187
Only index persons	490	322	168
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	57.83	56.55	60.40
Only index persons	57.18	55.57	60.24

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	98	57	41
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	59.16	55.48	64.28

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
102: Matched controls
1020

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H02.7

ICD-10 Finland

Other degenerative disorders of eyelid and periocular area

+∞

105.2

H02.3

ICD-10 Finland

Blepharochalasis

189.9

45.0

CBJ50

NOMESCO Finland

Operation for ptosis of eyebrow

326.8

25.9

3745A

ICD-9 Finland

Other disorders of eyelids, Degenerative disorders of eyelid and periocular area

+∞

21.6

CBB21

NOMESCO Finland

Correction of lax skin and resection of herniated fat in upper eyelid

+∞

20.5

CBB11

NOMESCO Finland

Resection of lax skin in upper eyelid

+∞

17.2

QAJ10

NOMESCO Finland

Browlift

+∞

16.0

WX725

NOMESCO Finland

Noninvasive ventilation

18.3

14.4

H02.5

ICD-10 Finland

Other disorders affecting eyelid function

+∞

13.9

TPH04

NOMESCO Finland

Cathetrisation of vein

4.8

13.3

134

WX704

NOMESCO Finland

Intubation

12.2

13.1

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

5.2

12.7

H02.4

ICD-10 Finland

Ptosis of eyelid

134.6

11.7

CBB10

NOMESCO Finland

Excision of redundant skin of eyelid

+∞

11.7

WX720

NOMESCO Finland

Own respiration

12.5

9.7

N02AX02

ATC

tramadol; systemic, rectal

3.5

8.9

296

3201

FHL

Removal of a small eyelid tumor in the operating room

97.8

8.6

Z01.8

ICD-10 Finland

Other specified special examinations

3.5

7.8

138

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

4.6

6.2

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3019150) Specific gravity of Urine by Refractometry

176

2.73

5.25

5.7

4.0

1.02

1.01

kg/l

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.61

4.08

5.1

6.0

—

(3044889) 12 lead EKG panel

583

2.44

3.62

5.6

3.8

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

153

2.36

3.52

4.7

3.2

73.89

228.90

ng/l

0.86

119

(3019060) Gas panel - Arterial blood

3.03

3.32

4.7

3.8

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

326

2.05

3.12

2.0

1.9

86.02

95.95

pmol/l

1.01

162

(3026008) Bacteria identified in Urine by Culture

241

2.09

3.08

2.9

3.2

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

818

0.47

3.01

11.5

13.2

75.52

79.34

ml/min/173m2

0.70

666

(3031040) Bacteria [#/volume] in Urine by Automated count

542

2.12

2.97

5.5

4.1

—

338.30

—

(3021589) Normoblasts [#/volume] in Blood

381

0.49

2.38

6.9

9.9

0.00

0.01

e9/l

0.53

312

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

431

1.80

2.20

7.3

5.9

1.21

mmol/l

0.07

357

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

2.28

2.10

1.7

1.6

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

839

2.53

2.08

16.0

13.8

21.44

22.88

mg/l

0.18

651

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

389

1.75

2.05

6.3

5.4

1.21

1.22

mmol/l

0.10

350

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.73

2.00

2.3

2.2

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

3.50

2.00

3.1

2.1

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.89

1.98

1.1

1.0

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

3.13

1.98

1.0

—

(3022217) INR in Platelet poor plasma by Coagulation assay

405

1.71

1.89

20.7

12.0

1.26

1.25

inr

—

122

(3042936) Bacteria identified in Isolate by Culture

115

1.92

1.68

1.5

1.9

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

189

1.75

1.64

6.1

3.9

—

(3012516) Albumin [Mass/volume] in Urine

234

1.68

1.58

3.1

3.2

111.70

605.96

mg/l

0.72

154

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

382

1.61

1.54

2.8

2.4

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.61

1.48

2.7

3.3

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.52

1.42

1.6

2.2

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.59

1.32

1.5

2.0

—

(36660697) Celiac disease serology panel - Serum

2.08

1.27

1.2

—

(40761511) CBC panel - Blood by Automated count

891

2.32

1.27

18.4

12.2

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

194

1.61

1.25

1.7

1.6

0.68

1.14

mg/l

1.28

151

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

128

1.70

1.20

1.8

1.3

—

(40760888) Immunoglobulin light chains.free panel - Serum

2.57

1.16

1.0

3.6

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

2.57

1.16

1.4

1.6

—

(3020682) Albumin/Creatinine [Ratio] in Urine

251

1.53

1.15

3.5

3.6

27.46

11.05

mg/mmol

0.60

158

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.45

1.10

2.0

1.1

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

678

1.55

1.09

6.9

7.3

65.97

79.18

u/l

4.97

625

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.76

1.07

1.9

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

487

1.44

1.01

6.8

9.5

4.01

4.11

e9/l

0.12

426

(40758558) Short blood count panel - Blood

216

0.59

1.00

5.2

7.3

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.99

0.0

1.1

—

(3052851) Hemolysis interference index of Serum or Plasma

0.00

0.99

0.0

2.9

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.98

0.0

1.4

—

(3003694) ABO and Rh group [Type] in Blood

226

0.61

0.98

1.3

1.4

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

224

1.48

0.95

5.4

4.3

21.30

21.61

0.04

110

(3007853) Bacteria identified in Skin by Aerobe culture

1.68

0.94

2.2

1.5

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

154

1.55

0.93

1.3

88.40

41.91

iu/ml

—

(40761535) Cells panel - Urine sediment

1.74

0.93

6.7

4.2

—

(3049717) Cytology report of Urine Cyto stain

2.13

0.91

3.0

2.8

—

(3037467) Urinalysis macro (dipstick) panel - Urine

585

1.42

0.89

5.5

3.9

—

(3019198) Lymphocytes [#/volume] in Blood

409

1.38

0.83

5.2

5.7

2.01

1.91

e9/l

0.26

368

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

193

0.63

0.79

2.2

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.72

0.79

1.7

1.6

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.78

0.0

1.1

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.78

0.0

5.5

—

(3002256) Pathology report gross observation

108

0.53

0.77

1.0

1.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.60

0.77

2.0

1.7

—

(3000494) Fungus identified in Specimen by Culture

1.60

0.77

1.2

1.5

—

(3013115) Eosinophils [#/volume] in Blood

413

1.36

0.77

5.2

5.8

0.21

0.18

e9/l

0.96

367

(40760892) CBC W Ordered Manual Differential panel - Blood

375

1.36

0.76

6.0

6.3

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

144

1.48

0.75

1.3

1.66

11.42

u/ml

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

171

1.45

0.74

1.5

1.8

448.74

440.93

pmol/l

0.06

141

(3013512) EKG study

245

0.68

0.73

4.3

4.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

322

1.34

0.68

5.3

3.8

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.68

0.68

1.3

2.2

—

(3006315) Basophils [#/volume] in Blood

400

1.32

0.67

5.3

5.7

0.04

e9/l

0.13

349

(3001604) Monocytes [#/volume] in Blood

400

1.32

0.67

5.3

5.6

0.57

e9/l

0.04

349

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

1.76

0.64

1.8

3.1

25.10

25.46

mmol/l

—

(1761868) Lipid panel - Serum or Plasma

293

0.72

0.64

2.0

3.2

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

317

1.32

0.61

6.6

4.1

25.89

30.65

ng/l

0.21

221

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.58

0.61

1.5

1.3

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.61

0.0

1.8

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.57

0.59

5.4

2.6

3.30

5.88

ug/l

1.20

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.52

0.59

2.1

1.5

—

(3008898) HLA-B27 [Presence]

1.71

0.58

1.0

1.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

135

1.40

0.56

1.9

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.52

0.55

1.4

—

(3017732) Neutrophils [#/volume] in Blood

1.52

0.55

2.1

2.3

3.71

9.78

e9/l

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.52

0.53

1.8

1.7

—

(3022145) Colonoscopy Study observation

0.57

0.47

1.2

1.3

—

(3033658) Prothrombin time (PT) actual/Normal

216

0.74

0.46

3.0

3.6

90.00

92.07

0.14

211

(40768804) Tissue Pathology biopsy report

331

0.79

0.45

2.0

2.1

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

105

1.39

0.44

20.9

7.9

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

114

1.37

0.44

1.3

1.4

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.41

0.0

1.4

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.5

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.41

0.0

1.5

—

(40768443) Skin Pathology biopsy report

1.49

0.41

1.2

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.40

0.0

1.8

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.40

0.0

3.4

—

7.19

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.40

0.0

3.4

—

1.53

—

(40768793) Breast Pathology biopsy report

0.00

0.39

0.0

1.2

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.64

0.37

1.0

2.0

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.45

0.36

1.7

—

(3044640) Blood type and Crossmatch panel - Blood

260

0.80

0.34

2.0

2.3

—

(3018095) Leukocytes [#/volume] in Urine

309

1.20

0.33

3.0

3.7

10.16

51.90

e6/l

1.67

218

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

568

1.18

0.31

2.8

41.13

50.29

u/l

0.64

530

(3030467) Casts [#/volume] in Urine by Automated count

255

0.83

0.29

3.3

3.0

0.12

0.51

e6/l

1.99

187

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.28

0.23

4.9

1.5

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.21

0.0

1.0

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.5

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.5

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.2

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.2

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.5

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.5

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.2

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.5

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.5

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

2.5

—

35.87

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.4

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.21

0.0

3.3

—

4.05

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.21

0.0

3.3

—

105.42

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.21

0.0

3.3

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.21

0.0

3.7

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.21

0.0

1.5

—

(3020148) Glutamate decarboxylase 65 Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.21

0.0

1.5

—

32.15

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.1

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.24

0.20

1.5

1.2

—

(3000012) Reticulocyte production index

0.00

0.20

0.0

1.7

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.16

0.19

5.7

8.2

93.33

94.69

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

312

1.13

0.19

3.8

3.0

—

(21494755) Public health laboratory ask at order entry panel

1.14

0.16

1.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

231

0.89

0.14

2.2

3.3

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

138

0.85

0.14

3.3

2.9

2.17

2.16

e6/l

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

109

0.81

0.13

7.6

6.0

104.33

103.91

mmol/l

—

109

(46235355) HIV 1 and 2 tests - Meaningful Use set

124

1.15

0.12

4.1

1.7

—

(36304419) Bacteria [Presence] in Urine

242

1.10

0.11

3.0

2.9

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.14

0.10

1.6

1.5

—

(3025941) Bacteria identified in Stool by Culture

1.07

0.09

2.0

1.3

—

(3022621) pH of Urine by Test strip

1.12

0.09

2.5

2.4

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

156

1.11

0.08

3.3

2.8

0.81

1.28

e6/l

0.59

(3000492) Spirometry study

0.85

0.07

1.1

1.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.12

0.06

4.9

1.5

—

(3026782) Osmolality of Urine

161

0.92

0.05

1.9

3.1

400.30

565.19

mosm/kgh2o

—

138

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

497

1.05

0.05

3.5

2.8

—

(3002582) Erythrocytes [#/volume] in Urine

271

0.95

0.04

2.9

3.1

19.16

42.57

e6/l

0.76

199

(3023368) Bacteria identified in Blood by Culture

220

1.06

0.04

4.7

4.3

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

142

1.07

0.02

2.1

3.0

0.85

0.81

mmol/l

0.92

131

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

1.07

0.01

1.8

4.6

208.20

249.06

u/l

—

(40768797) Stomach Pathology biopsy report

113

0.97

0.00

1.5

1.3

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

167

1.02

0.00

2.0

3.0

0.87

0.75

ug/l

0.10

111

(3007164) IgA [Mass/volume] in Serum or Plasma

171

0.99

0.00

1.5

1.4

2.09

2.85

g/l

—

110

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

-0.00

0.0

1.7

—

16.63

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

-0.00

0.0

1.6

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

1.0

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

1.3

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

17.31

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

-0.00

0.0

1.4

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

-0.00

0.0

2.2

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

-0.00

0.0

4.0

—

(3027831) CD3-CD16+CD56+ (Natural killer) cells/100 cells in Blood

0.00

-0.00

0.0

2.0

—

12.20

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.5

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.0

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

-0.00

0.0

1.1

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

1.0

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3041423) Sjogrens syndrome-A extractable nuclear 60kD Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

-0.00

0.0

1.6

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

(3000991) Gas panel - Venous blood

0.93

-0.00

8.3

6.5

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(4146454) Self-monitoring of blood glucose

0.00

-0.00

0.0

3.3

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

-0.00

0.0

1.0

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

-0.00

0.0

1.6

—

(40768441) Liver Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(3035880) pH of Pleural fluid

0.00

-0.00

0.0

1.1

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

-0.00

0.0

1.8

—

(3041067) Sjogrens syndrome-A extractable nuclear 52kD Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

-0.00

0.0

1.6

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

-0.00

0.0

1.4

—

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.5

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.3

—

79.00

—

(3044927) Protein electrophoresis panel - Urine

0.00

-0.00

0.0

1.2

—

(3034274) Bile acid [Moles/volume] in Serum --fasting

0.00

-0.00

0.0

3.2

—

6.35

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3011648) Oxygen content in Venous blood

0.00

-0.00

0.0

1.0

—

10.18

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

-0.00

0.0

2.6

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.5

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

(3012565) Volume of 24 hour Urine

0.00

-0.00

0.0

2.5

—

1791.67

—

(3014271) Vancomycin [Susceptibility]

0.00

-0.00

0.0

2.0

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

266.40

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

-0.00

0.0

1.0

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.6

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

-0.00

0.0

1.2

—

6.42

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

-0.00

0.0

1.0

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(40765096) Chromosome analysis panel by Banding

0.00

-0.00

0.0

1.0

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

-0.00

0.0

1.8

—

(3000034) Microalbumin [Mass/volume] in Urine

0.00

-0.00

0.0

1.4

—

5.44

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

-0.00

0.0

1.2

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

-0.00

0.0

1.3

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

-0.00

0.0

1.5

—

(3007798) IgG/Albumin [Mass Ratio] in Cerebral spinal fluid

0.00

-0.00

0.0

1.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.01

-0.00

9.8

4.0

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

-0.00

0.0

1.1

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(3005033) Fetal Nuchal fold Thickness US

0.00

-0.00

0.0

1.6

—

(3005715) Vancomycin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

3.7

—

12.00

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

1.56

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

-0.00

0.0

2.2

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

-0.00

0.0

1.5

—

(40768806) Pleura Pathology biopsy report

0.00

-0.00

0.0

2.0

—

(3051651) Icteric interference index of Serum or Plasma

0.00

-0.00

0.0

2.0

—

(21494815) CD4 cells/100 lymphocytes in Specimen

0.00

-0.00

0.0

1.9

—

33.61

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

-0.00

0.0

1.6

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

-0.00

0.0

3.4

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.6

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.0

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

-0.00

0.0

1.0

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3004809) Band form neutrophils/100 leukocytes in Blood

0.00

-0.00

0.0

3.6

—

2.00

—

(4200892) Spirometry reversibility

0.98

-0.00

2.1

1.3

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

-0.00

0.0

1.7

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

-0.00

0.0

1.8

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

0.96

-0.00

1.8

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_EYELIDDEGEN and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_EYELIDDEGEN.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: H7_EYELIDDEGEN – Other degenerative disorders of eyelid and periocular area

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other degenerative disorders of eyelid and periocular area

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints