Other degenerative disorders of eyelid and periocular area

H7_EYELIDDEGEN

eyelid disease: A disease involving the eyelid.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H02.7 Hospital discharge: ICD-9 — 3745 Cause of death: ICD-10 — H02.7 Cause of death: ICD-9 — 3745 2 out of 7 registries used, show all original rules.	96
4. Check minimum number of events None	96
5. Include endpoints None	96
6. Filter based on genotype QC (FinnGen only)	96

Control definitions (FinnGen only)

Control exclude: H7_LIDLACRIMALORBIT

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H02
Name in latin: Aliae morbositates degenerativae palpebrarum et areae periocularis

NAME	H7_EYELIDDEGEN
CONTROL_EXCLUDE	H7_LIDLACRIMALORBIT
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H027
HD_ICD_9	3745
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H027
COD_ICD_9	3745
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other degenerative disorders of eyelid and periocular area based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	546	357	187
Only index persons	490	322	168
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	57.83	56.55	60.40
Only index persons	57.18	55.57	60.24

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	96	52	44
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	58.22	54.58	62.52

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
84: Matched controls
841

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H02.7

ICD-10 Finland

Other degenerative disorders of eyelid and periocular area

+∞

84.0

H02.3

ICD-10 Finland

Blepharochalasis

653.0

40.7

CBJ50

NOMESCO Finland

Operation for ptosis of eyebrow

+∞

25.3

3745A

ICD-9 Finland

Other disorders of eyelids, Degenerative disorders of eyelid and periocular area

+∞

19.5

CBB11

NOMESCO Finland

Resection of lax skin in upper eyelid

+∞

15.0

CBB21

NOMESCO Finland

Correction of lax skin and resection of herniated fat in upper eyelid

+∞

11.7

CBB10

NOMESCO Finland

Excision of redundant skin of eyelid

+∞

11.7

QAJ10

NOMESCO Finland

Browlift

+∞

9.5

3201

FHL

Removal of a small eyelid tumor in the operating room

+∞

9.5

H02.5

ICD-10 Finland

Other disorders affecting eyelid function

+∞

8.5

H02.4

ICD-10 Finland

Ptosis of eyelid

75.3

6.5

WX725

NOMESCO Finland

Noninvasive ventilation

7.9

6.0

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3019150) Specific gravity of Urine by Refractometry

167

2.72

4.95

5.7

4.0

1.0

kg/l

—

(3044889) 12 lead EKG panel

550

2.51

3.58

5.6

3.9

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.42

3.52

4.8

6.1

—

(3031040) Bacteria [#/volume] in Urine by Automated count

512

2.24

3.13

5.4

4.1

—

419.4

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

313

2.07

3.04

1.9

85.7

95.9

pmol/l

0.97

156

(3019060) Gas panel - Arterial blood

2.92

2.94

4.4

3.8

—

(3009542) Hematocrit [Volume Fraction] of Blood

715

2.95

2.82

18.5

13.9

38.1

40.0

0.64

499

(3026008) Bacteria identified in Urine by Culture

226

2.04

2.74

2.9

3.3

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

147

2.16

2.69

4.8

3.1

77.3

230.7

ng/l

0.82

118

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

765

0.49

2.66

11.5

13.4

75.7

78.7

ml/min/173m2

0.47

624

(3032080) INR in Blood by Coagulation assay

323

1.89

2.41

19.7

7.9

1.3

1.2

inr

—

102

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.98

2.28

2.3

2.2

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

3.00

2.06

1.1

1.0

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

3.14

1.98

1.0

—

(3021589) Normoblasts [#/volume] in Blood

362

0.52

1.98

6.9

10.1

0.0

e9/l

0.53

297

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

367

1.76

1.95

6.4

5.4

1.2

mmol/l

0.06

328

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

788

2.40

1.82

16.3

13.9

21.4

23.3

mg/l

0.25

611

(3042936) Bacteria identified in Isolate by Culture

105

2.01

1.79

1.6

2.0

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

177

1.82

1.78

6.1

3.9

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

407

1.67

1.68

7.5

6.1

1.2

mmol/l

0.10

332

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

117

1.90

1.61

1.8

1.3

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

3.13

1.61

3.5

2.1

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

355

1.63

1.55

5.0

3.9

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.71

1.54

2.7

3.4

—

(36660697) Celiac disease serology panel - Serum

2.26

1.51

1.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

158

1.69

1.31

4.0

6.4

—

(40760888) Immunoglobulin light chains.free panel - Serum

2.87

1.30

1.0

3.8

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

185

1.64

1.27

1.7

1.6

0.7

1.1

mg/l

1.22

147

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.49

1.26

1.7

2.2

—

(3012516) Albumin [Mass/volume] in Urine

222

1.59

1.22

3.2

3.3

116.8

642.9

mg/l

0.72

145

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.90

1.17

1.5

1.6

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

2.58

1.16

1.4

1.6

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.58

1.16

2.0

1.2

—

(40761511) CBC panel - Blood by Automated count

837

2.20

1.15

18.3

12.5

—

(40761535) Cells panel - Urine sediment

1.88

1.13

6.7

4.2

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

643

1.56

1.05

6.8

7.1

65.9

79.6

u/l

4.94

591

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.34

1.04

1.6

1.9

—

(3019198) Lymphocytes [#/volume] in Blood

381

1.46

1.01

5.3

5.8

1.9

e9/l

0.06

340

(3052851) Hemolysis interference index of Serum or Plasma

0.00

0.99

0.0

3.1

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.87

0.99

1.7

1.5

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

223

1.50

0.99

5.4

4.4

21.3

21.6

0.04

110

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

144

1.59

0.98

1.3

97.8

45.7

iu/ml

—

(3037467) Urinalysis macro (dipstick) panel - Urine

553

1.47

0.97

5.4

4.0

—

(3002256) Pathology report gross observation

101

0.47

0.96

1.0

1.2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.71

0.94

2.0

1.9

—

(3003694) ABO and Rh group [Type] in Blood

211

0.61

0.92

1.2

1.5

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.69

0.90

2.2

1.5

—

(1761868) Lipid panel - Serum or Plasma

275

0.66

0.88

2.1

3.2

—

(3008898) HLA-B27 [Presence]

2.00

0.86

1.0

1.1

—

(3020682) Albumin/Creatinine [Ratio] in Urine

239

1.44

0.84

3.9

28.8

11.6

mg/mmol

0.60

150

(3000494) Fungus identified in Specimen by Culture

1.65

0.84

1.2

1.4

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

460

1.40

0.83

7.0

9.1

4.1

e9/l

0.04

400

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

133

1.53

0.81

1.3

1.7

12.7

u/ml

—

(3001604) Monocytes [#/volume] in Blood

373

1.39

0.81

5.5

5.7

0.6

e9/l

0.12

323

(3006315) Basophils [#/volume] in Blood

373

1.39

0.81

5.5

5.8

0.0

e9/l

0.11

324

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.80

0.0

1.5

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.80

0.0

1.6

—

46.7

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.79

0.0

1.1

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.78

0.79

1.3

2.2

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.78

0.0

5.5

—

(3017732) Neutrophils [#/volume] in Blood

1.77

0.78

2.1

2.4

3.7

4.1

e9/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.77

0.78

1.4

—

(3013115) Eosinophils [#/volume] in Blood

386

1.37

0.76

5.5

5.9

0.2

e9/l

0.91

341

(40758558) Short blood count panel - Blood

200

0.65

0.73

5.2

6.6

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

1.97

0.71

1.8

3.3

25.1

25.4

mmol/l

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.59

0.70

2.1

1.7

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.65

0.68

1.8

1.6

—

(3049717) Cytology report of Urine Cyto stain

1.83

0.67

3.0

2.8

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

305

1.35

0.67

5.3

3.9

—

(3026493) Urate [Moles/volume] in Serum or Plasma

222

1.37

0.64

3.2

2.8

396.5

12694.0

umol/l

1.75

193

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.69

0.64

2.1

1.5

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.60

0.62

5.4

2.6

3.3

5.9

ug/l

1.23

(3013512) EKG study

237

0.70

0.62

4.3

4.2

—

(40768804) Tissue Pathology biopsy report

301

0.73

0.62

2.0

2.1

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.59

0.0

1.2

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.48

0.58

20.9

8.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

179

0.68

0.56

2.2

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.53

0.52

1.7

1.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

129

1.39

0.50

1.9

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.53

0.49

1.6

1.4

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

168

1.32

0.45

1.3

1.8

469.1

441.5

pmol/l

0.23

140

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.44

0.43

4.9

1.5

—

(40768443) Skin Pathology biopsy report

1.54

0.42

1.2

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.41

0.0

1.4

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.5

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.41

0.0

3.5

—

7.3

—

(40768793) Breast Pathology biopsy report

0.00

0.41

0.0

1.2

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.41

0.0

3.5

—

1.6

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.41

0.0

1.5

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.40

0.0

1.8

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.39

0.0

1.8

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

309

1.21

0.34

7.0

4.1

26.5

31.0

ng/l

0.18

216

(3018095) Leukocytes [#/volume] in Urine

294

1.19

0.28

3.1

3.8

10.8

53.9

e6/l

1.64

209

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

296

1.18

0.26

3.9

3.1

—

(3012544) pH of Venous blood

1.22

0.26

6.3

3.3

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

144

1.22

0.24

3.3

2.8

0.8

1.2

e6/l

0.45

(46235355) HIV 1 and 2 tests - Meaningful Use set

116

1.24

0.23

4.1

1.6

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.26

0.23

1.6

1.3

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.21

0.0

1.0

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.21

0.0

1.1

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.21

0.0

3.8

—

(3000242) Tau protein [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

286.8

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(43055225) Phosphorylated tau 181 [Mass/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.21

0.0

1.1

—

37.4

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.4

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.3

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.3

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.3

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

2.5

—

35.9

—

(3042810) Amyloid beta 42 peptide [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

440.0

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.21

0.0

3.3

—

105.4

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.21

0.0

3.3

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.21

0.0

3.3

—

4.0

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.21

0.0

1.5

—

(42870588) Differential panel, method unspecified - Blood

252

1.16

0.21

6.0

5.0

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.29

0.21

1.5

1.2

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.21

0.0

1.5

—

32.2

—

(3020148) Glutamate decarboxylase 65 Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.1

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.21

0.20

5.7

8.4

93.3

94.8

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

100

1.23

0.19

1.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.24

0.18

4.9

1.5

—

(21494755) Public health laboratory ask at order entry panel

1.18

0.18

1.3

—

(3030467) Casts [#/volume] in Urine by Automated count

244

0.87

0.17

3.3

3.1

0.1

0.4

e6/l

1.91

180

(3044640) Blood type and Crossmatch panel - Blood

241

0.89

0.14

2.0

2.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

220

0.89

0.13

2.0

3.4

—

(3000492) Spirometry study

0.82

0.08

1.0

1.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.04

0.07

9.7

4.1

—

(3007164) IgA [Mass/volume] in Serum or Plasma

158

1.09

0.06

1.5

1.4

2.1

2.8

g/l

—

102

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

1.12

0.05

1.8

4.7

208.2

251.5

u/l

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

130

0.91

0.05

3.3

3.0

2.2

e6/l

—

(36304419) Bacteria [Presence] in Urine

230

1.06

0.04

3.2

2.9

—

(3002582) Erythrocytes [#/volume] in Urine

259

0.95

0.03

3.0

3.2

19.5

41.2

e6/l

0.66

192

(40768797) Stomach Pathology biopsy report

107

0.93

0.02

1.6

1.3

—

(3023368) Bacteria identified in Blood by Culture

212

0.99

0.00

4.8

4.3

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

165

1.04

0.00

2.0

3.0

0.9

0.8

ug/l

0.10

111

(3012095) Magnesium [Moles/volume] in Serum or Plasma

134

0.97

0.00

2.0

3.0

0.9

0.8

mmol/l

0.88

124

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

458

1.01

0.00

3.7

2.7

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

1.6

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.0

1.4

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.6

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

266.4

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.2

—

6.4

—

(3000034) Microalbumin [Mass/volume] in Urine

0.00

0.0

1.4

—

5.4

—

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

24.4

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

1.0

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

3.2

—

(4027681)

0.00

0.0

1.0

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

2.2

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

1.0

—

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.0

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.2

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

4.0

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.02

0.00

1.8

1.2

—

(3035880) pH of Pleural fluid

0.00

0.0

1.1

—

(3004809) Band form neutrophils/100 leukocytes in Blood

0.00

0.0

3.6

—

2.0

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

0.0

1.0

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.0

1.2

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.3

—

(3041423) Sjogrens syndrome-A extractable nuclear 60kD Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(44806420)

0.00

0.0

2.0

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.6

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.6

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

1.9

—

17.8

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.0

1.6

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

1.8

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.6

—

(4146454)

0.00

0.0

3.3

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.1

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3000012) Reticulocyte production index

0.00

0.0

1.4

—

(3005715) Vancomycin [Mass/volume] in Serum or Plasma

0.00

0.0

3.7

—

12.0

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

2.6

—

(3000991) Gas panel - Venous blood

0.96

0.00

8.3

6.5

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.2

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

0.0

1.7

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.3

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

2.5

—

3.4

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.0

1.0

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(4010399)

1.02

0.00

2.1

1.2

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.6

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.0

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3012565) Volume of 24 hour Urine

0.00

0.0

2.5

—

1791.7

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.0

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

2.0

—

(4024509)

0.00

0.0

1.3

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.6

—

(3034274) Bile acid [Moles/volume] in Serum --fasting

0.00

0.0

3.2

—

6.3

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.6

—

(3014271) Vancomycin [Susceptibility]

0.00

0.0

2.0

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.6

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

2.2

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.1

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.0

1.5

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.7

—

16.6

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(3041067) Sjogrens syndrome-A extractable nuclear 52kD Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

0.0

1.8

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(3022621) pH of Urine by Test strip

0.94

0.00

2.0

2.5

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

3.4

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

2.6

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3011648) Oxygen content in Venous blood

0.00

0.0

1.0

—

10.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_EYELIDDEGEN and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_EYELIDDEGEN.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: H7_EYELIDDEGEN – Other degenerative disorders of eyelid and periocular area

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other degenerative disorders of eyelid and periocular area

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints