Polyp of middle ear

H8_POLYPMIDD

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H74.4
  • Cause of death: ICD-10 H74.4

2 out of 7 registries used, show all original rules.

58

4. Check minimum number of events

None

58

5. Include endpoints

None

58

6. Filter based on genotype QC (FinnGen only)

58

Control definitions (FinnGen only)

Control exclude
H8_MIDDLEMASTOID

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H74
Name in latin
Polypus auris mediae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 794 336 456
Only index persons 694 295 399
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.02
Median age at first event (years)
Whole population 11.75 10.66 12.26
Only index persons 13.86 11.53 15.58

-FinnGen-

Key figures

All Female Male
Number of individuals 58 30 28
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 48.50 44.56 52.71

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
10
29
3.96
3.21
3.0
7.0
—
—
—
0
0
14
52
3.23
3.16
1.6
1.3
—
—
—
0
0
10
31
3.69
2.93
3.0
8.2
—
—
—
0
0
12
43
3.26
2.85
2.7
7.0
—
7.5
—
0
6
8
27
3.27
2.02
3.3
1.6
—
—
—
0
0
11
46
2.72
1.99
3.8
1.4
—
—
—
0
0
8
29
3.03
1.87
2.5
2.2
96.8
127.1
ng/l
—
8
24
5
12
4.45
1.86
1.0
1.6
—
—
—
0
0
9
37
2.69
1.56
3.1
1.8
64.4
66.6
g/l
—
9
32
10
50
2.21
1.25
27.4
16.7
1.5
1.2
inr
—
5
11
20
130
1.82
1.25
3.3
2.8
—
—
—
0
0
18
114
1.84
1.21
5.5
3.7
—
—
—
0
0
0
36
0.00
1.18
0.0
4.4
—
—
—
0
0
0
30
0.00
1.00
0.0
1.2
—
—
—
0
0
0
32
0.00
0.98
0.0
2.3
—
—
—
0
0
10
159
0.55
0.89
2.3
2.7
—
—
—
0
0
8
46
1.86
0.87
1.6
1.4
—
—
—
0
0
7
41
1.80
0.73
1.1
1.2
—
—
—
0
0
8
123
0.59
0.63
1.3
1.4
—
—
—
0
0
0
21
0.00
0.61
0.0
1.6
—
—
—
0
0
0
21
0.00
0.61
0.0
2.5
—
—
—
0
0
45
402
1.53
0.61
4.7
3.8
1.3
1.2
mmol/l
0.16
40
362
9
131
0.63
0.61
1.9
3.7
—
—
—
0
0
10
65
1.65
0.60
1.5
1.9
—
—
—
0
0
33
279
1.42
0.59
7.7
9.3
4.1
4.1
e9/l
0.01
28
246
47
506
0.62
0.58
14.9
12.2
—
—
—
0
0
6
97
0.57
0.58
2.2
3.0
457.5
547.0
mosm/kgh2o
—
6
85
9
60
1.59
0.58
2.0
1.6
—
—
—
0
0
46
417
1.50
0.53
5.2
4.2
1.5
1.5
mmol/l
0.39
39
376
17
130
1.44
0.52
4.5
3.3
54.9
6.9
mg/mmol
—
10
78
15
112
1.46
0.51
4.1
4.2
—
—
—
0
0
16
122
1.43
0.49
3.9
2.8
138.8
574.9
mg/l
—
9
81
7
101
0.65
0.44
2.1
2.4
7.0
5.9
e6/l
—
7
91
5
33
1.56
0.42
1.0
1.3
—
—
—
0
0
5
33
1.56
0.42
1.4
1.6
—
—
—
0
0
5
33
1.56
0.42
2.4
1.6
1.1
1.1
g/l
—
5
26
20
163
1.35
0.42
4.0
6.2
—
—
—
0
0
20
163
1.35
0.42
2.0
1.8
—
—
—
0
0
0
15
0.00
0.42
0.0
1.6
—
—
—
0
0
0
16
0.00
0.42
0.0
1.4
—
320.8
—
0
7
0
16
0.00
0.42
0.0
6.1
—
—
—
0
0
35
310
1.33
0.41
2.9
4.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
9
124
0.68
0.40
1.2
3.5
—
—
—
0
0
6
46
1.34
0.34
1.3
1.2
—
—
—
0
0
32
285
1.27
0.34
3.1
4.3
—
53.2
—
0
5
45
419
1.33
0.32
5.0
4.3
4.7
4.6
mmol/l
0.34
40
382
46
431
1.33
0.30
5.5
4.8
2.7
2.7
mmol/l
0.23
39
393
5
71
0.68
0.28
2.4
2.5
26.6
28.7
s
—
5
71
20
230
0.80
0.28
2.5
4.0
—
0.0
—
0
39
10
126
0.75
0.28
2.8
3.3
—
—
—
0
0
42
445
0.80
0.25
15.2
15.7
35.8
39.6
%
0.92
30
335
14
166
0.79
0.25
3.6
3.7
51.0
49.2
e6/l
—
8
120
13
107
1.28
0.24
2.5
3.9
—
—
—
0
0
5
38
1.34
0.24
2.2
2.1
8.6
9.5
g/l
—
5
31
20
227
0.82
0.24
4.5
5.6
—
0.0
—
0
38
11
89
1.29
0.23
1.7
1.7
—
—
—
0
0
5
42
1.21
0.22
4.0
4.4
19.1
11.9
ug/l
—
5
34
12
143
0.80
0.22
2.7
3.1
25.9
24.6
e6/l
—
7
113
10
122
0.78
0.21
1.2
1.4
—
0.7
—
0
24
10
122
0.78
0.21
4.3
3.4
—
7.4
—
0
20
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
6
47
1.31
0.21
1.5
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
7
58
1.23
0.19
1.0
1.3
—
—
—
0
0
8
69
1.18
0.17
1.1
1.4
—
—
—
0
0
16
181
0.84
0.17
2.4
3.5
—
—
—
0
0
21
231
0.86
0.16
2.6
4.1
—
0.0
—
0
39
42
400
1.18
0.16
6.9
5.5
43.6
40.4
mmol/mol
0.59
37
373
50
484
1.24
0.15
13.8
13.5
19.9
23.9
mg/l
0.40
41
374
18
166
1.12
0.09
5.2
4.0
21.5
40.9
ng/l
0.52
12
119
6
58
1.04
0.09
2.8
5.0
—
—
—
0
0
8
77
1.05
0.08
1.1
1.2
—
39.0
—
0
27
45
439
1.11
0.06
5.2
4.3
2.2
1.9
mu/l
0.83
39
395
18
190
0.92
0.04
2.3
5.8
31.5
35.3
g/l
1.10
18
181
29
300
0.93
0.04
2.8
3.9
—
—
—
0
0
10
93
1.09
0.02
1.4
1.8
453.4
481.5
pmol/l
—
10
78
42
427
0.94
0.01
4.9
4.5
6.1
5.9
mmol/l
0.24
34
387
12
114
1.07
0.01
2.3
3.4
1.0
1.0
kg/l
—
5
16
13
124
1.06
0.01
4.1
5.4
—
—
—
0
0
11
111
0.99
0.00
2.5
4.9
—
—
—
0
0
24
239
1.01
0.00
5.5
6.2
9.3
15.4
umol/l
2.03
24
224
34
344
0.97
0.00
4.8
3.8
14.5
14.9
pmol/l
0.28
29
314
16
156
1.04
0.00
2.5
1.8
89.3
94.2
pmol/l
—
6
78
15
152
0.98
0.00
1.6
3.1
2.3
2.4
mmol/l
—
9
133
0
6
0.00
0.00
0.0
8.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
254.0
—
0
6
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
0.3
—
0
6
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
5
51
0.98
0.00
7.0
9.2
—
—
—
0
0
0
8
0.00
0.00
0.0
2.4
—
7.4
—
0
8
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
37.4
—
0
5
0
5
0.00
0.00
0.0
5.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
2.4
—
8.9
—
0
8
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
62.7
—
0
7
0
5
0.00
0.00
0.0
1.2
—
6.6
—
0
5
0
8
0.00
0.00
0.0
1.3
—
9.8
—
0
8
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
90.2
—
0
9
0
8
0.00
0.00
0.0
1.3
—
0.4
—
0
8
0
7
0.00
0.00
0.0
5.9
—
1.3
—
0
7
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
2.4
—
5.2
—
0
8
0
5
0.00
0.00
0.0
1.0
—
178.2
—
0
5
0
7
0.00
0.00
0.0
1.7
—
5.0
—
0
7
0
7
0.00
0.00
0.0
4.1
—
0.9
—
0
7

Mortality – FinRegistry

Association

Association between endpoint H8_POLYPMIDD and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H8_POLYPMIDD.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: H8_POLYPMIDD – Polyp of middle ear

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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