This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Transepidermal elimination disorders
L12_TRANSEPIDERMELIMINATION
skin disease: Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpoints |
52 |
6. Filter based on genotype QC (FinnGen only) |
52 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L80-L99
- Name in latin
- Perturbationes eliminationis transepidermalis
Similar endpoints
↥List of similar endpoints to
Transepidermal elimination disorders
based on the number of shared cases.
Similar with more cases:
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 466 | 280 | 178 |
| Only index persons | 395 | 249 | 146 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 56.95 | 57.00 | 56.49 |
| Only index persons | 55.30 | 55.34 | 55.24 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 52 | 34 | 18 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 57.17 | 55.07 | 61.14 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
No data available
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
38
160
6.11
8.60
5.0
3.0
148.4
109.8
ug/l
0.69
38
144
20
50
5.88
8.26
2.3
1.7
—
—
—
0
0
26
85
5.12
7.84
7.2
3.0
32.0
89.4
ng/l
0.47
19
64
22
66
5.04
7.28
2.8
1.8
—
—
—
0
0
15
32
6.18
7.22
9.8
4.6
2.6
3.1
mmol/l
0.15
15
27
19
51
5.29
7.14
3.0
1.5
—
—
—
0
0
19
51
5.29
7.14
7.5
2.9
26.3
18.9
%
0.51
12
43
41
205
5.73
7.00
22.6
9.9
1.2
1.2
mmol/l
0.34
35
180
11
18
7.48
6.73
10.0
6.3
26.3
26.2
mmol/l
0.03
11
18
15
35
5.62
6.53
9.7
4.4
6.0
6.1
kpa
0.09
15
35
24
93
3.94
5.45
1.5
1.1
2.1
2.9
u/ml
—
7
25
13
34
4.76
4.88
2.3
1.3
—
—
—
0
0
46
339
4.09
3.29
17.9
7.8
94.5
80.6
u/l
0.94
46
319
30
171
2.78
3.20
2.5
1.8
99.4
105.0
pmol/l
0.27
17
72
6
9
7.35
2.95
2.0
1.9
4.9
4.2
g/l
—
6
9
8
18
5.05
2.93
7.5
3.1
1.6
1.1
%
—
8
18
31
192
2.52
2.64
8.2
4.6
—
—
—
0
0
8
24
3.74
2.29
2.3
1.4
—
—
—
0
0
7
19
4.09
2.24
11.3
3.4
61.4
53.8
%
—
7
19
8
25
3.59
2.20
1.1
1.4
—
—
—
0
0
38
275
2.42
2.09
8.7
3.2
67.6
57.7
u/l
0.26
38
252
18
96
2.34
2.03
3.4
2.6
—
—
—
0
0
5
11
4.90
1.99
1.8
1.1
—
—
—
0
0
13
62
2.46
1.84
1.5
1.4
—
—
—
0
0
23
141
2.13
1.83
5.2
3.0
—
—
—
0
0
5
13
4.13
1.75
1.8
1.5
259.0
233.2
%
—
5
13
35
255
2.14
1.75
4.0
3.2
—
—
—
0
0
5
16
3.34
1.47
1.0
1.0
—
—
—
0
0
5
16
3.34
1.47
1.0
1.2
—
—
—
0
0
16
93
2.04
1.42
1.9
1.6
22.3
20.3
nmol/l
0.27
16
75
5
18
2.96
1.31
1.2
2.1
—
—
—
0
0
14
84
1.91
1.12
1.9
1.8
481.1
483.5
pmol/l
0.01
14
71
14
87
1.83
1.00
1.4
1.3
57.4
18.1
iu/ml
—
6
28
12
71
1.90
0.99
3.7
2.8
0.7
0.7
e6/l
—
7
40
8
44
1.96
0.91
7.1
3.2
—
—
—
0
0
11
65
1.88
0.91
3.9
3.0
0.8
4.5
e6/l
—
6
34
6
32
1.99
0.85
25.2
8.0
1.0
1.6
%
—
6
32
25
196
1.53
0.73
8.8
5.2
0.0
0.0
estimate
—
5
32
5
27
1.94
0.70
1.2
1.5
—
—
—
0
0
5
30
1.74
0.63
1.2
1.7
—
—
—
0
0
25
203
1.45
0.58
6.2
3.7
0.0
0.0
estimate
—
5
32
19
147
1.46
0.56
6.5
3.7
—
—
—
0
0
20
163
1.37
0.43
5.5
3.5
35.6
37.0
ng/l
0.03
12
108
9
65
1.46
0.42
1.1
1.5
—
—
—
0
0
11
85
1.37
0.31
1.5
1.3
14.4
12.1
u/ml
—
5
36
45
430
1.34
0.25
5.3
4.6
6.5
6.0
mmol/l
0.68
45
396
0
11
0.00
0.21
0.0
4.5
—
23.7
—
0
11
0
11
0.00
0.21
0.0
1.6
—
210.5
—
0
11
0
14
0.00
0.20
0.0
1.6
—
45.1
—
0
14
6
77
0.75
0.17
3.0
3.9
—
23.9
—
0
32
10
106
0.93
0.01
2.9
4.4
0.9
1.6
ug/l
—
10
92
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
5.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_TRANSEPIDERMELIMINATION and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_TRANSEPIDERMELIMINATION | 1.881 [1.35, 2.62] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.06 |
During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 259 females with L12_TRANSEPIDERMELIMINATION died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_TRANSEPIDERMELIMINATION | 2.845 [1.63, 4.95] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 149 males with L12_TRANSEPIDERMELIMINATION died.
Mortality risk
Mortality risk for people of age
years, who have L12_TRANSEPIDERMELIMINATION.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.202% | 0.466% |
| 5 | 0.896% | 2.788% |
| 10 | 2.435% | 7.127% |
| 15 | 4.718% | 13.85% |
| 20 | 8.183% | 22.8% |
Relationships between endpoints
↥Index endpoint: L12_TRANSEPIDERMELIMINATION – Transepidermal elimination disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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