Other effects of reduced temperature

ST19_OTHER_EFFEC_REDUCED_TEMPE

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — T69 Cause of death: ICD-10 — T69 2 out of 7 registries used, show all original rules.	85
4. Check minimum number of events None	85
5. Include endpoints None	85
6. Filter based on genotype QC (FinnGen only)	84

Control definitions (FinnGen only)

Control exclude: ST19_OTHER_UNSPE_EFFEC_EXTER_CAUSES

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: T6[6-9]|T7[0-8]
Name in latin: Alii effectus caloris deminuti

NAME	ST19_OTHER_EFFEC_REDUCED_TEMPE
CONTROL_EXCLUDE	ST19_OTHER_UNSPE_EFFEC_EXTER_CAUSES
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	T69
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	T69
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other effects of reduced temperature based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	84	49	35
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	47.88	42.67	55.16

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
85: Matched controls
850

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

T69.1

ICD-10 Finland

Chilblains

586.4

38.2

T69.8

ICD-10 Finland

Other specified effects of reduced temperature

+∞

28.8

T69.9

ICD-10 Finland

Effect of reduced temperature, unspecified

+∞

15.0

X31

ICD-10 Finland

Exposure to excessive natural cold

+∞

13.9

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

10.8

11.8

I73.0

ICD-10 Finland

Raynaud syndrome

68.9

10.9

T69.0

ICD-10 Finland

Immersion hand and foot

+∞

10.6

E0000UV, ,

ATC

3.9

8.6

238

X57

ICD-10 Finland

Unspecified privation

29.1

6.3

C08CA02

ATC

felodipine; oral

6.8

6.2

N06AB10

ATC

escitalopram; oral

3.4

6.1

113

H02AB06

ATC

prednisolone; systemic

3.1

6.0

253

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3037522) Nuclear Ab [Titer] in Serum

6.13

14.74

2.0

1.3

656.67

553.68

titre

0.08

(40760892) CBC W Ordered Manual Differential panel - Blood

314

4.10

8.50

9.2

6.3

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

9.36

8.38

1.9

—

(3006315) Basophils [#/volume] in Blood

329

4.02

8.12

7.1

6.2

0.05

0.04

e9/l

0.91

292

(3001604) Monocytes [#/volume] in Blood

329

4.02

8.12

7.2

6.1

0.60

0.57

e9/l

0.51

294

(3019198) Lymphocytes [#/volume] in Blood

339

4.06

8.07

7.0

6.1

1.81

1.78

e9/l

0.11

310

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

115

3.86

7.84

1.5

1.3

18.83

24.37

iu/ml

0.25

(3013115) Eosinophils [#/volume] in Blood

343

3.98

7.84

9.0

6.3

0.18

0.17

e9/l

0.03

308

(40768443) Skin Pathology biopsy report

9.36

6.62

1.3

1.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

3.68

6.49

1.8

1.5

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

392

3.56

6.28

8.9

10.5

4.30

4.13

e9/l

0.24

345

(3004616) Nuclear Ab [Presence] in Serum

13.94

6.26

1.2

1.1

—

(3004588) Protein electrophoresis panel - Serum or Plasma

4.58

6.03

1.4

2.0

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

6.51

4.27

1.1

—

(3037467) Urinalysis macro (dipstick) panel - Urine

468

2.84

4.01

6.1

4.2

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

107

2.73

3.84

1.5

1.3

31.11

12.73

u/ml

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

7.23

3.76

1.4

1.0

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

146

2.50

3.62

1.9

2.8

—

(3007164) IgA [Mass/volume] in Serum or Plasma

154

2.47

3.59

1.4

2.44

2.21

g/l

0.41

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

140

2.49

3.54

2.0

1.7

—

(3023420) DNA double strand Ab [Units/volume] in Serum

9.10

3.31

1.7

1.6

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

234

2.23

3.21

2.1

1.9

99.38

96.55

pmol/l

0.13

109

(3021589) Normoblasts [#/volume] in Blood

287

2.21

3.18

10.8

9.4

0.00

e9/l

-0.00

240

(3021788) Differential panel - Synovial fluid

7.96

3.10

1.0

1.3

—

(3013512) EKG study

177

2.18

2.82

5.4

3.9

—

(3044640) Blood type and Crossmatch panel - Blood

194

2.15

2.78

2.2

2.7

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.85

2.78

1.5

1.4

—

(3020630) Protein [Mass/volume] in Serum or Plasma

2.83

2.58

1.7

2.2

66.47

66.76

g/l

0.06

(3007853) Bacteria identified in Skin by Aerobe culture

2.45

2.57

3.1

1.6

—

(3021960) Folate [Moles/volume] in Serum or Plasma

143

2.18

2.56

1.7

1.5

20.06

19.85

nmol/l

0.03

121

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

269

2.01

2.54

6.8

8.4

1.22

1.21

mmol/l

0.04

238

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

319

1.96

2.39

2.6

2.9

—

(3018095) Leukocytes [#/volume] in Urine

239

1.97

2.35

3.9

3.4

18.48

84.54

e6/l

0.84

170

(46235355) HIV 1 and 2 tests - Meaningful Use set

172

2.04

2.33

2.3

1.9

—

(3031040) Bacteria [#/volume] in Urine by Automated count

460

2.03

2.29

5.1

4.0

—

74.43

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

165

2.04

2.29

1.3

1.2

0.56

1.18

u/ml

—

(3042936) Bacteria identified in Isolate by Culture

2.26

2.27

2.1

2.4

—

(3037756) Immunofixation for Serum or Plasma

5.82

2.24

1.4

1.8

—

(3000494) Fungus identified in Specimen by Culture

2.43

2.20

1.3

1.9

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

634

2.56

2.12

4.4

4.5

1.87

1.88

mu/l

0.04

567

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

147

1.99

2.03

1.8

0.76

1.22

mg/l

0.63

110

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

3.54

2.01

1.1

1.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

225

1.85

1.94

4.7

2.8

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

4.35

1.85

1.4

1.1

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

4.35

1.85

3.2

1.1

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.94

1.84

1.1

2.0

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

292

1.78

1.82

7.9

10.2

1.21

mmol/l

0.10

246

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

247

1.79

1.81

4.1

3.3

27.92

32.66

ng/l

0.13

159

(40758558) Short blood count panel - Blood

145

1.91

1.79

5.0

7.4

—

(3033658) Prothrombin time (PT) actual/Normal

145

1.91

1.79

3.5

94.33

91.46

0.21

145

(3002582) Erythrocytes [#/volume] in Urine

205

1.81

1.75

3.1

2.9

47.56

38.38

e6/l

0.10

157

(3000764) Benzodiazepines [Presence] in Urine

2.70

1.73

2.7

1.3

—

(3027944) Amphetamines [Presence] in Urine

2.70

1.73

2.7

1.3

—

(3028300) Cannabinoids [Presence] in Urine

2.63

1.71

2.8

1.3

—

(3027008) Opiates [Presence] in Urine

2.63

1.71

2.7

1.3

—

(3009261) Glucose [Presence] in Urine by Test strip

353

1.74

1.70

5.1

3.7

0.00

estimate

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

3.32

1.69

1.3

—

(3021601) Nitrite [Presence] in Urine by Test strip

344

1.73

1.69

7.0

5.0

0.00

estimate

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.65

1.64

3.9

3.6

25.07

24.48

mmol/l

—

(3035350) Ketones [Presence] in Urine by Test strip

347

1.71

1.61

5.2

3.6

0.00

estimate

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

2.03

1.59

1.3

1.6

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.57

1.58

1.3

1.1

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

3.47

1.54

2.8

1.6

—

(40761535) Cells panel - Urine sediment

2.33

1.46

5.2

3.3

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

3.25

1.46

1.0

1.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

155

1.76

1.44

1.3

1.6

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

107

1.87

1.40

3.7

3.4

56.00

49.34

ng/l

0.08

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

520

1.71

1.36

3.7

3.9

14.58

14.72

pmol/l

0.17

463

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

167

1.70

1.33

4.2

3.1

1976.26

1488.29

ng/l

0.23

140

(3019060) Gas panel - Arterial blood

2.17

1.31

4.9

15.5

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

2.42

1.31

1.9

1.6

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

151

1.72

1.29

3.7

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

2.50

1.26

1.8

14.1

22.72

25.09

mmol/l

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.73

1.23

1.8

1.2

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

648

1.90

1.22

18.0

12.2

83.40

86.40

ml/min/173m2

0.46

519

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.40

1.21

1.7

1.4

—

(3016879) Cocaine [Presence] in Urine

2.16

1.19

3.1

1.3

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

2.16

1.19

4.4

2.3

216.50

121.35

ng/l

—

(3026782) Osmolality of Urine

130

1.70

1.16

3.6

2.9

526.15

529.93

mosm/kgh2o

0.03

107

(3023368) Bacteria identified in Blood by Culture

147

1.67

1.16

6.3

4.5

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.45

1.15

3.0

2.2

—

(3022217) INR in Platelet poor plasma by Coagulation assay

283

1.54

1.12

12.0

10.9

1.03

1.22

inr

—

(3011288) Drugs identified in Urine by Screen method

2.46

1.10

2.6

1.5

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

2.46

1.10

1.2

1.1

—

(40761511) CBC panel - Blood by Automated count

742

2.33

1.10

21.3

12.3

—

(3030467) Casts [#/volume] in Urine by Automated count

184

1.60

1.09

3.0

2.8

0.34

0.19

e6/l

0.39

137

(3050129) First trimester maternal screen panel - Serum or Plasma

2.22

1.08

1.9

1.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.84

1.06

1.5

1.9

—

(3000850) Epithelial cells [#/volume] in Urine

144

1.61

1.00

3.4

2.2

3.09

4.21

e6/l

0.54

125

(3029937) Albumin [Presence] in Urine by Test strip

197

1.54

0.99

5.5

3.7

0.00

estimate

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

649

1.72

0.97

4.5

4.2

5.67

5.86

mmol/l

0.62

585

(4200892) Spirometry reversibility

1.82

0.96

1.4

1.6

—

(36304419) Bacteria [Presence] in Urine

181

1.54

0.95

3.2

2.6

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.90

0.89

1.6

1.8

—

(1002224) Polysomnography panel

2.07

0.89

1.0

1.1

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

2.00

0.86

9.2

3.3

24.17

23.90

mmol/l

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

2.00

0.86

2.5

1.3

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.94

0.83

6.2

27.0

—

(3019225) pH of Specimen

1.72

0.72

6.1

5.8

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

129

1.50

0.71

1.6

1.4

—

(3018418) pH of Serum or Plasma

183

1.43

0.70

5.4

4.3

7.40

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

1.90

0.69

1.8

1.5

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

1.90

0.69

1.8

1.5

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.90

0.69

1.8

1.7

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

1.90

0.69

1.8

1.5

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

1.90

0.69

1.8

1.5

—

(3045414) Leukocytes [Presence] in Urine

1.77

0.65

3.2

1.6

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

1.77

0.65

1.8

1.6

—

(3044889) 12 lead EKG panel

434

0.74

0.65

4.6

3.6

—

(3000991) Gas panel - Venous blood

1.53

0.59

7.8

9.0

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.53

0.59

2.3

4.8

1.23

1.22

mmol/l

—

(40761536) Microorganisms panel - Urine sediment

1.61

0.58

6.6

3.6

—

(36660697) Celiac disease serology panel - Serum

1.59

0.57

1.4

1.1

—

(3022145) Colonoscopy Study observation

1.58

0.55

1.4

1.3

—

(3000492) Spirometry study

1.50

0.55

1.2

1.4

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.4

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.41

0.0

4.4

—

37.36

—

(40768793) Breast Pathology biopsy report

0.00

0.40

0.0

1.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.37

0.38

1.8

1.6

—

(3003694) ABO and Rh group [Type] in Blood

203

1.25

0.35

1.5

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

281

1.22

0.33

6.0

3.6

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.26

0.26

2.1

1.3

—

(3002256) Pathology report gross observation

1.21

0.25

1.1

1.2

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.34

0.23

4.2

4.1

70.58

53.20

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.27

0.23

4.6

2.4

2.18

1.31

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.27

0.23

4.6

2.4

0.48

0.66

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.3

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.0

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.21

0.0

3.2

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

3.2

—

20.90

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.3

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.3

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.7

—

9.11

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.21

0.0

1.0

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.21

0.0

1.0

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

3.5

—

3.01

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.4

—

(40768797) Stomach Pathology biopsy report

1.26

0.20

1.4

1.2

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

0.00

0.20

0.0

1.7

—

2.86

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.3

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.20

0.0

1.6

—

(3050449) Albumin [Mass/time] in Urine collected for unspecified duration

0.00

0.20

0.0

2.3

—

117.58

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.18

0.17

1.3

1.7

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.12

0.16

2.3

1.3

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

102

1.21

0.16

2.0

2.9

1.11

3.03

e6/l

—

(40768804) Tissue Pathology biopsy report

267

1.13

0.16

2.3

1.8

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.11

0.15

5.0

7.1

103.67

104.18

mmol/l

—

(3026008) Bacteria identified in Urine by Culture

218

0.89

0.12

4.7

2.9

—

(3025941) Bacteria identified in Stool by Culture

1.17

0.10

1.2

1.3

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.09

0.10

5.6

4.5

138.00

129.61

g/l

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

1.14

0.09

2.0

1.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.04

0.08

12.0

3.1

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

108

1.13

0.08

2.0

2.8

1.69

0.99

e6/l

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

158

1.09

0.06

4.0

4.5

18.27

23.07

—

(3012516) Albumin [Mass/volume] in Urine

178

1.09

0.06

5.8

3.4

168.36

78.57

mg/l

0.38

113

(3020682) Albumin/Creatinine [Ratio] in Urine

189

1.08

0.05

6.5

4.0

5.72

13.46

mg/mmol

1.03

118

(3041096) Erythrocytes [Presence] in Urine by Automated

210

1.06

0.04

6.4

3.2

—

(3019832) Treponema pallidum Ab [Presence] in Serum

102

1.09

0.03

1.7

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

118

0.92

0.03

1.7

2.2

—

(1761868) Lipid panel - Serum or Plasma

248

0.96

0.02

2.0

2.8

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

127

0.94

0.02

1.7

2.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

515

0.98

0.00

3.2

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(3006462) Nitrate [Presence] in Urine

0.00

-0.00

0.0

1.4

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

3.2

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

3.7

—

61.67

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

(3028433) Virus identified in Specimen by Culture

0.00

-0.00

0.0

1.4

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

-0.00

0.0

2.2

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.88

-0.00

7.0

7.1

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

3.2

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

6.1

—

194.19

—

(40763470) Parainfluenza virus 4 RNA [Presence] in Isolate by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3002079) Sodium [Moles/time] in 24 hour Urine

0.00

-0.00

0.0

1.1

—

128.95

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(40763324) Parainfluenza virus 1 RNA [Presence] in Isolate by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

1801.67

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.8

—

(4281824) Cell count and differential, peritoneal fluid

0.00

-0.00

0.0

1.0

—

(3051593) INR in Capillary blood by Coagulation assay

0.00

-0.00

0.0

13.8

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.7

—

(3045716) Anion gap in Serum or Plasma

0.00

-0.00

0.0

1.8

—

7.24

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.8

—

(3042631) Mycobacterium sp identified in Specimen

0.00

-0.00

0.0

1.9

—

(4146454) Self-monitoring of blood glucose

0.00

-0.00

0.0

3.9

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

-0.00

0.0

1.3

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.4

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.8

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

-0.00

0.0

1.3

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

-0.00

0.0

1.0

—

6.59

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

-0.00

0.0

2.2

—

4.04

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3023419) Bacteria identified in Sputum by Culture

0.00

-0.00

0.0

2.2

—

(21494755) Public health laboratory ask at order entry panel

0.91

-0.00

1.6

1.3

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

3.6

—

877.00

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

297.00

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.90

-0.00

1.6

1.8

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3011648) Oxygen content in Venous blood

0.00

-0.00

0.0

3.0

—

11.07

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.1

—

(3017315) Amylase [Enzymatic activity/volume] in Urine

0.00

-0.00

0.0

1.4

—

114.40

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.8

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: ST19_OTHER_EFFEC_REDUCED_TEMPE – Other effects of reduced temperature

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

R13

FinnGen R12 + FinRegistry

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Other effects of reduced temperature

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Other effects of reduced temperature (ST19_OTHER_EFFEC_REDUCED_TEMPE)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints