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Diphtheria

EFO Endpoint Browser PheWeb

AB1_DIBTHERIA

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A36
  • Hospital discharge: ICD-9 — 03[2]
  • Hospital discharge: ICD-8 — 03[2]
  • Cause of death: ICD-10 — A36
  • Cause of death: ICD-9 — 03[2]
  • Cause of death: ICD-8 — 03[2]

2 out of 7 registries used, show all original rules.

57

4. Check minimum number of events

None

57

5. Include endpoints

None

57

6. Filter based on genotype QC (FinnGen only)

55

Control definitions (FinnGen only)

Control exclude
AB1_OTHER_BACTERIAL

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 405 216 184
Only index persons 333 187 146
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 39.49 35.56 43.16
Only index persons 37.12 34.68 40.24

-FinnGen-

Key figures

All Female Male
Number of individuals 55 27 28
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 61.11 56.99 65.08

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
57
Matched controls
570
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A36.9
ICD-10 Finland
Diphtheria, unspecified
+∞
49.3
40
*
R4110
NOMESCO Finland
Physiotherapy
5.5
9.6
32
107
ZXD10
NOMESCO Finland
Scheduled procedure
4.8
8.0
35
141
Z3226
NOMESCO Finland
Physiotherapist
4.9
7.3
22
65
Z2221
NOMESCO Finland
Medical doctor
4.5
7.2
28
101
A36.0
ICD-10 Finland
Pharyngeal diphtheria
+∞
6.4
6
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
37
66
14.13
23.59
3.9
2.2
0.10
2.18
e6/l
—
10
33
40
123
8.55
14.27
4.3
2.0
—
—
—
0
0
40
126
8.29
13.82
4.4
2.1
0.57
0.18
e6/l
0.41
23
85
40
137
7.44
12.30
4.4
2.2
19.53
31.48
e6/l
0.29
23
97
42
156
7.43
11.66
5.9
2.8
86.45
31.94
e6/l
0.43
23
104
29
81
6.25
10.85
6.4
2.9
—
—
—
0
0
15
19
10.28
7.71
3.5
4.4
24.73
24.95
mmol/l
0.09
15
19
28
97
4.71
7.70
3.9
3.3
—
—
—
0
0
18
33
7.47
7.42
4.3
4.2
—
—
—
0
0
39
181
4.66
7.14
12.5
5.4
1.21
1.22
mmol/l
0.31
39
167
17
31
7.35
7.01
2.9
4.0
1.06
1.30
mmol/l
0.65
17
31
28
105
4.28
6.79
5.8
6.2
—
—
—
0
0
41
203
4.63
6.75
9.5
7.9
0.00
0.00
e9/l
0.80
25
161
30
122
4.08
6.43
5.1
3.7
—
7.41
—
0
21
39
200
4.01
5.79
12.7
5.2
1.21
1.22
mmol/l
0.40
39
172
38
193
3.91
5.70
9.6
5.2
0.63
0.68
%
0.24
38
185
39
205
3.86
5.48
9.5
5.4
10.02
8.25
%
1.48
39
199
19
64
3.95
5.15
1.8
1.7
31.84
28.40
s
1.59
19
64
38
202
3.64
5.13
9.6
5.2
2.32
2.81
%
0.95
38
196
39
212
3.66
5.06
9.6
5.1
58.19
55.43
%
0.56
39
205
39
212
3.66
5.06
9.5
5.3
26.75
30.55
%
0.80
39
206
39
212
3.66
5.06
9.9
5.4
0.68
0.57
e9/l
0.78
25
185
46
279
4.36
5.04
4.9
3.6
—
111.00
—
0
7
39
214
3.60
4.94
9.9
5.3
0.04
0.04
e9/l
0.29
25
186
14
32
5.45
4.85
1.1
1.4
—
—
—
0
0
23
92
3.51
4.81
2.1
1.8
1.06
0.97
mg/l
0.09
16
80
12
23
6.31
4.78
3.7
5.9
93.67
95.18
%
0.52
12
23
15
39
4.84
4.64
5.6
2.7
6.33
6.46
umol/l
0.02
15
33
16
51
3.97
4.63
4.3
4.5
105.44
104.35
mmol/l
0.37
16
51
39
220
3.45
4.61
10.3
5.5
0.19
0.18
e9/l
0.12
28
195
37
203
3.34
4.57
9.6
5.5
—
—
—
0
0
39
221
3.42
4.56
9.9
5.4
2.60
1.98
e9/l
0.30
28
197
43
259
3.69
4.54
6.5
3.7
6.13
6.48
mmol/l
1.42
43
240
14
35
4.96
4.49
22.4
7.6
25.79
24.30
mmol/l
0.69
14
35
41
243
3.45
4.38
15.7
9.1
3.56
3.81
e9/l
0.43
28
212
12
26
5.55
4.36
3.4
5.4
0.83
1.30
%
1.63
12
26
12
26
5.55
4.36
3.7
5.3
0.53
0.79
%
1.38
12
26
20
78
3.41
4.29
1.7
1.9
—
—
—
0
0
17
61
3.55
4.13
1.3
1.5
—
—
—
0
0
15
50
3.71
4.04
1.1
1.4
—
—
—
0
0
7
8
9.76
3.89
1.1
1.1
—
—
—
0
0
7
9
8.66
3.67
3.9
4.9
26.14
22.96
mg/l
—
7
9
7
9
8.66
3.67
4.0
4.9
30.06
34.34
mg/l
—
7
9
11
27
4.79
3.63
1.3
1.5
—
—
—
0
0
13
40
3.90
3.43
3.5
2.4
—
—
—
0
0
16
63
3.14
3.30
5.1
3.1
0.82
0.83
mmol/l
0.17
16
57
13
45
3.45
3.28
2.5
2.0
—
—
—
0
0
12
37
3.83
3.17
1.5
1.2
—
—
—
0
0
24
122
2.67
3.11
3.7
2.0
—
—
—
0
0
6
9
7.29
2.94
3.2
3.3
—
—
—
0
0
26
141
2.55
2.93
2.0
1.9
79.47
102.87
pmol/l
1.35
11
66
8
18
4.98
2.91
3.8
4.6
—
—
—
0
0
42
300
2.52
2.43
3.1
3.4
—
—
—
0
0
5
9
5.96
2.26
1.0
1.1
—
—
—
0
0
6
14
4.65
2.21
2.3
1.7
0.24
0.23
g/l
—
6
14
43
318
2.43
2.19
12.8
6.4
81.72
75.59
u/l
0.40
43
298
50
405
2.91
2.13
40.5
13.5
13.80
15.35
%
3.52
50
397
17
89
2.30
1.96
1.8
1.4
1.87
2.24
g/l
0.58
11
60
8
28
3.15
1.95
3.4
2.4
0.23
0.24
g/l
—
8
28
5
12
4.45
1.86
2.2
1.3
—
—
—
0
0
7
24
3.18
1.78
1.7
4.1
—
—
—
0
0
39
290
2.09
1.77
5.4
3.6
—
—
—
0
0
11
49
2.54
1.76
1.4
1.4
—
—
—
0
0
5
13
4.10
1.75
1.4
1.3
—
—
—
0
0
27
179
1.97
1.67
2.7
2.0
—
—
—
0
0
5
14
3.81
1.65
2.6
1.7
1.16
1.12
g/l
—
5
14
7
28
2.70
1.50
1.1
1.3
—
—
—
0
0
6
22
2.92
1.47
1.2
1.0
—
—
—
0
0
52
454
2.65
1.46
32.5
12.0
139.50
139.71
mmol/l
0.30
52
441
6
127
0.41
1.39
1.8
2.8
—
—
—
0
0
52
460
2.48
1.31
33.3
12.1
3.92
3.98
mmol/l
1.03
52
446
0
34
0.00
1.20
0.0
4.0
—
0.25
—
0
8
15
91
1.88
1.15
3.9
2.8
0.65
0.70
ug/l
—
8
62
5
22
2.39
1.05
1.0
2.1
1.22
1.28
%
—
5
22
5
22
2.39
1.05
1.0
2.1
0.62
0.72
%
—
5
22
0
31
0.00
1.00
0.0
4.2
—
0.00
—
0
5
8
45
1.90
0.89
1.3
1.2
—
—
—
0
0
0
24
0.00
0.81
0.0
1.1
—
—
—
0
0
0
25
0.00
0.81
0.0
3.0
—
—
—
0
0
9
54
1.79
0.79
1.8
1.3
—
—
—
0
0
52
477
2.03
0.75
29.0
12.7
73.77
74.64
umol/l
0.09
52
477
5
25
2.09
0.74
1.2
1.1
—
—
—
0
0
16
113
1.58
0.71
3.2
2.2
—
—
—
0
0
51
474
1.72
0.58
10.0
9.8
—
—
—
0
0
6
38
1.65
0.56
1.3
1.5
—
—
—
0
0
13
174
0.67
0.54
1.8
2.5
—
—
—
0
0
8
55
1.53
0.45
1.6
1.5
—
—
—
0
0
12
157
0.70
0.43
3.2
3.2
10.17
35.80
ng/l
—
6
104
0
15
0.00
0.42
0.0
3.0
—
—
—
0
0
7
51
1.42
0.33
1.4
1.3
—
—
—
0
0
5
39
1.31
0.23
1.4
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
7
57
1.26
0.19
1.3
1.4
—
—
—
0
0
44
420
1.21
0.17
4.1
4.1
5.96
5.88
mmol/l
0.10
37
385
15
131
1.20
0.16
1.6
1.4
—
—
—
0
0
7
83
0.82
0.07
1.4
1.6
349.29
471.30
pmol/l
—
7
71
42
410
1.09
0.05
4.8
5.0
38.40
39.41
mmol/mol
0.27
37
382
10
93
1.09
0.02
4.7
3.9
—
1.02
—
0
9
11
114
0.96
0.00
1.9
1.7
59.91
54.62
u/l
0.34
11
106
0
6
0.00
0.00
0.0
1.0
—
260.00
—
0
6
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
109.63
—
0
8
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
3.97
—
0
8
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
1.42
—
0
6
0
8
0.00
0.00
0.0
4.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
1.66
—
0
6
0
9
0.00
-0.00
0.0
1.3
—
7.43
—
0
9
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
8.48
—
0
9
0
7
0.00
-0.00
0.0
2.0
—
22.91
—
0
7
0
5
0.00
-0.00
0.0
3.6
—
17.20
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
203.29
—
0
7
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.0
—
27.86
—
0
7
0
5
0.00
-0.00
0.0
3.0
—
7.52
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
89.03
—
0
7
0
9
0.00
-0.00
0.0
1.2
—
5.10
—
0
9
0
9
0.00
-0.00
0.0
3.0
—
57.67
—
0
9
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.0
—
3.51
—
0
9

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_DIBTHERIA and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have AB1_DIBTHERIA.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: AB1_DIBTHERIA – Diphtheria

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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