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Other parasitologically confirmed or unspecified malaria

Endpoint Browser PheWeb

AB1_MALARIA_NOS

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — B53, B54
  • Hospital discharge: ICD-9 — 08[4]
  • Hospital discharge: ICD-8 — 08[4]
  • Hospital discharge: excluded ICD-9 — 084[0-1]
  • Hospital discharge: excluded ICD-8 — 084[0-1]
  • Cause of death: ICD-10 — B53, B54
  • Cause of death: ICD-9 — 08[4]
  • Cause of death: ICD-8 — 08[4]
  • Cause of death: excluded ICD-9 — 084[0-1]
  • Cause of death: excluded ICD-8 — 084[0-1]

2 out of 7 registries used, show all original rules.

88

4. Check minimum number of events

None

88

5. Include endpoints

None

88

6. Filter based on genotype QC (FinnGen only)

77

Control definitions (FinnGen only)

Control exclude
AB1_PROTOZOAL

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1013 379 602
Only index persons 891 349 542
Unadjusted period prevalence (%)
Whole population 0.02 0.01 0.02
Only index persons 0.02 0.01 0.02
Median age at first event (years)
Whole population 33.83 31.03 35.70
Only index persons 34.17 31.81 35.70

-FinnGen-

Key figures

All Female Male
Number of individuals 77 38 39
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 37.66 34.72 40.53

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
88
Matched controls
880
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
B54
ICD-10 Finland
Unspecified malaria
+∞
63.4
53
*
B50.9
ICD-10 Finland
Plasmodium falciparum malaria, unspecified
+∞
10.6
10
*
0846X
ICD-9 Finland
Malaria, unspecified
+∞
7.4
7
*
08499
ICD-8 Finland
Malaria, Unspecified forms
+∞
6.3
6
*
B53.0
ICD-10 Finland
Plasmodium ovale malaria
+∞
6.3
6
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
38
197
2.63
4.59
2.8
2.8
—
—
—
0
0
37
199
2.48
4.05
3.0
2.8
0.23
0.39
e6/l
0.49
30
149
44
259
2.40
3.92
4.2
3.6
16.69
53.76
e6/l
1.31
34
185
29
142
2.55
3.84
3.0
2.4
575.91
572.90
mosm/kgh2o
0.03
23
121
40
232
2.33
3.62
3.3
2.9
7.21
35.45
e6/l
1.59
33
181
21
100
2.44
2.88
2.1
2.5
—
—
—
0
0
32
185
2.15
2.80
1.8
1.4
—
—
—
0
0
21
114
2.11
2.10
2.7
2.7
2.36
1.85
e6/l
0.12
12
60
13
57
2.50
2.09
1.3
1.3
—
—
—
0
0
33
213
1.88
2.03
2.5
2.2
—
—
—
0
0
38
257
1.84
2.02
2.9
1.9
—
—
—
0
0
15
75
2.21
1.82
1.5
1.3
—
—
—
0
0
11
48
2.48
1.79
8.9
11.3
6.65
9.24
mmol/l
1.28
11
48
16
84
2.11
1.73
1.6
1.9
—
—
—
0
0
27
173
1.81
1.67
1.7
2.1
—
—
—
0
0
11
50
2.37
1.65
15.5
11.9
—
—
—
0
0
6
21
2.99
1.53
1.2
1.2
—
—
—
0
0
27
182
1.70
1.38
3.7
4.3
—
—
—
0
0
0
37
0.00
1.38
0.0
1.8
—
—
—
0
0
14
77
1.97
1.34
1.6
2.2
2.17
1.80
%
0.24
14
70
43
331
1.58
1.29
9.9
6.4
—
—
—
0
0
41
313
1.58
1.27
13.2
9.3
0.00
0.00
e9/l
-0.00
34
254
14
79
1.92
1.25
8.6
8.9
1.04
1.02
mmol/l
0.17
14
73
5
20
2.59
1.16
4.2
2.1
1.61
1.75
mg/l
—
5
20
13
74
1.89
1.14
18.8
9.1
104.85
103.72
mmol/l
0.50
13
74
16
98
1.77
1.13
1.9
1.7
—
—
—
0
0
8
41
2.04
1.12
1.0
1.1
—
—
—
0
0
14
83
1.82
1.09
1.5
1.6
—
—
—
0
0
7
33
2.22
1.08
26.3
16.4
95.10
94.52
%
—
7
33
46
371
1.50
1.06
8.4
5.8
1.67
1.82
e9/l
0.72
39
339
20
133
1.65
1.06
2.8
3.1
1294.71
88.06
ng/l
0.67
14
98
51
424
1.48
0.99
11.7
9.4
3.33
4.06
e9/l
1.87
45
370
7
36
2.02
0.99
20.9
7.4
26.30
25.02
mmol/l
—
7
36
44
358
1.46
0.94
8.6
5.8
0.04
0.04
e9/l
0.24
38
322
44
358
1.46
0.94
8.6
5.8
0.50
0.56
e9/l
1.20
38
321
13
79
1.76
0.94
2.8
1.8
—
—
—
0
0
6
28
2.22
0.93
3.8
2.0
—
—
—
0
0
10
56
1.89
0.92
3.5
2.9
0.22
0.22
g/l
—
10
51
10
56
1.89
0.92
3.6
5.1
0.80
0.65
%
—
5
23
13
80
1.73
0.90
2.7
3.0
5.85
8.95
umol/l
0.58
13
69
18
123
1.58
0.86
1.4
1.7
—
—
—
0
0
17
115
1.59
0.85
6.2
3.8
0.84
0.82
mmol/l
0.20
17
107
12
74
1.72
0.83
1.9
1.7
—
—
—
0
0
0
26
0.00
0.80
0.0
1.6
—
—
—
0
0
7
39
1.86
0.74
1.4
1.2
—
—
—
0
0
5
25
2.06
0.74
4.0
2.1
0.68
0.67
%
—
5
25
5
26
1.98
0.72
4.0
2.2
1.28
1.18
%
—
5
26
54
471
1.38
0.71
4.8
4.0
—
—
—
0
0
13
88
1.56
0.65
3.2
2.0
144.57
113.18
ug/g
—
7
71
10
63
1.66
0.65
1.9
1.7
—
—
—
0
0
5
30
1.71
0.62
24.4
30.0
—
—
—
0
0
77
723
1.52
0.58
18.1
13.0
28.23
22.90
mg/l
0.56
60
567
24
192
1.34
0.52
10.2
6.5
—
—
—
0
0
35
297
1.30
0.51
13.6
10.0
1.04
1.23
inr
—
10
89
80
760
1.58
0.49
14.0
11.6
—
—
—
0
0
53
476
1.29
0.49
3.6
3.4
—
—
—
0
0
23
186
1.32
0.47
3.5
3.5
0.00
0.00
estimate
—
7
58
12
161
0.71
0.46
1.5
1.3
2.19
2.67
g/l
—
7
98
0
19
0.00
0.39
0.0
10.0
—
—
—
0
0
49
535
0.81
0.39
5.3
3.7
9.27
11.03
mm/h
0.50
49
492
39
347
1.22
0.36
3.7
3.5
0.00
0.00
estimate
—
7
60
10
74
1.40
0.34
1.7
1.4
—
—
—
0
0
7
98
0.69
0.33
1.3
1.2
—
—
—
0
0
27
236
1.21
0.29
4.7
4.2
2.20
1.66
ug/l
0.82
22
212
5
41
1.23
0.22
1.4
1.3
—
—
—
0
0
5
41
1.23
0.22
1.4
1.3
—
—
—
0
0
5
41
1.23
0.22
1.4
1.3
—
—
—
0
0
5
41
1.23
0.22
5.0
5.0
4.36
4.43
pmol/l
—
5
36
5
42
1.20
0.22
1.2
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
1.49
—
0
10
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
5.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
37
342
1.14
0.19
5.6
4.9
0.00
0.00
estimate
—
8
61
6
52
1.16
0.19
8.7
3.6
—
—
—
0
0
16
184
0.84
0.19
3.3
2.8
—
—
—
0
0
37
344
1.13
0.17
3.8
3.4
0.00
0.00
estimate
—
8
66
8
67
1.21
0.17
3.9
2.7
273.38
374.92
nmol/l
—
8
59
22
240
0.89
0.13
2.1
1.9
96.21
97.48
pmol/l
—
9
115
31
290
1.11
0.12
2.8
2.7
—
—
—
0
0
17
188
0.88
0.12
5.2
3.3
246.74
87.23
mg/l
0.45
12
134
69
673
1.12
0.11
4.0
4.1
5.66
5.88
mmol/l
0.90
64
622
7
66
1.07
0.08
1.3
1.2
—
—
—
0
0
7
84
0.82
0.07
1.3
1.4
—
—
—
0
0
19
202
0.92
0.06
6.9
3.8
37.57
13.09
mg/mmol
0.38
13
138
15
161
0.92
0.05
3.5
3.6
—
—
—
0
0
18
169
1.08
0.05
3.3
3.2
—
—
—
0
0
23
240
0.94
0.04
2.9
3.1
23.59
43.59
ng/l
0.85
17
150
68
679
1.01
0.00
3.4
4.0
1.21
1.37
mmol/l
1.30
63
631
70
699
1.01
0.00
3.9
4.3
1.44
1.42
mmol/l
0.18
65
653
19
191
0.99
0.00
4.3
3.1
—
—
—
0
0
5
50
1.00
-0.00
2.2
2.1
21.50
8.36
ug/l
—
5
45
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
88.50
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
5.8
—
768.33
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
6.24
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
89.48
—
0
9
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
9.7
—
1185.83
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
55
0.90
-0.00
1.6
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
7.50
—
0
8
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
246.57
—
0
7
0
7
0.00
-0.00
0.0
3.6
—
—
—
0
0
8
86
0.92
-0.00
1.4
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.5
—
11.48
—
0
8
0
6
0.00
-0.00
0.0
4.7
—
0.63
—
0
6

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_MALARIA_NOS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have AB1_MALARIA_NOS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: AB1_MALARIA_NOS – Other parasitologically confirmed or unspecified malaria

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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