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Other parasitologically confirmed or unspecified malaria

Endpoint Browser PheWeb

AB1_MALARIA_NOS

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — B53, B54
  • Hospital discharge: ICD-9 — 08[4]
  • Hospital discharge: ICD-8 — 08[4]
  • Hospital discharge: excluded ICD-9 — 084[0-1]
  • Hospital discharge: excluded ICD-8 — 084[0-1]
  • Cause of death: ICD-10 — B53, B54
  • Cause of death: ICD-9 — 08[4]
  • Cause of death: ICD-8 — 08[4]
  • Cause of death: excluded ICD-9 — 084[0-1]
  • Cause of death: excluded ICD-8 — 084[0-1]

2 out of 7 registries used, show all original rules.

86

4. Check minimum number of events

None

86

5. Include endpoints

None

86

6. Filter based on genotype QC (FinnGen only)

86

Control definitions (FinnGen only)

Control exclude
AB1_PROTOZOAL

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1013 379 602
Only index persons 891 349 542
Unadjusted period prevalence (%)
Whole population 0.02 0.01 0.02
Only index persons 0.02 0.01 0.02
Median age at first event (years)
Whole population 33.83 31.03 35.70
Only index persons 34.17 31.81 35.70

-FinnGen-

Key figures

All Female Male
Number of individuals 86 39 47
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 37.70 34.30 40.53

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
74
Matched controls
737
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
B54
ICD-10 Finland
Unspecified malaria
+∞
47.0
40
*
B50.9
ICD-10 Finland
Plasmodium falciparum malaria, unspecified
+∞
9.6
9
*
0846X
ICD-9 Finland
Malaria, unspecified
+∞
6.3
6
*
08499
ICD-8 Finland
Malaria, Unspecified forms
+∞
6.3
6
*
B53.0
ICD-10 Finland
Plasmodium ovale malaria
+∞
6.3
6
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
37
194
2.59
4.35
2.9
2.8
—
—
—
0
0
29
137
2.68
4.17
2.8
2.4
598.1
587.6
mosm/kgh2o
0.09
23
117
36
195
2.46
3.87
3.1
2.8
0.2
0.4
e6/l
0.47
29
146
40
228
2.41
3.84
3.3
2.8
7.2
35.9
e6/l
1.59
33
178
43
254
2.39
3.80
4.3
3.5
17.2
54.6
e6/l
1.29
33
182
21
97
2.54
3.08
2.2
1.9
—
—
—
0
0
32
180
2.24
3.04
1.8
1.4
—
—
—
0
0
33
208
1.95
2.22
2.5
2.1
—
—
—
0
0
38
253
1.90
2.17
2.9
1.9
—
—
—
0
0
35
227
1.91
2.16
9.3
5.5
—
—
—
0
0
13
57
2.51
2.10
1.3
1.3
—
—
—
0
0
11
45
2.66
2.02
8.9
9.5
6.7
9.1
mmol/l
1.12
11
45
15
73
2.28
1.94
1.5
1.3
—
—
—
0
0
11
47
2.54
1.86
15.5
8.7
—
—
—
0
0
27
169
1.87
1.81
1.7
2.1
—
—
—
0
0
16
83
2.14
1.79
1.6
1.9
—
—
—
0
0
6
21
2.99
1.53
1.2
1.2
—
—
—
0
0
14
74
2.07
1.49
8.6
7.7
1.0
1.0
mmol/l
0.19
14
68
0
37
0.00
1.38
0.0
1.8
—
—
—
0
0
26
174
1.71
1.37
3.8
4.1
—
—
—
0
0
14
77
1.98
1.35
1.6
2.2
2.2
1.8
%
0.24
14
70
75
665
2.00
1.32
19.5
13.1
40.0
41.0
%
0.60
62
540
5
18
2.88
1.30
4.2
2.2
1.6
1.8
mg/l
—
5
18
16
94
1.86
1.28
1.9
1.7
—
—
—
0
0
13
71
1.98
1.27
18.8
7.1
104.8
103.8
mmol/l
0.47
13
71
40
305
1.58
1.25
13.5
9.4
0.0
0.0
e9/l
0.00
33
249
20
129
1.72
1.19
2.8
3.0
1393.0
90.2
ng/l
0.67
13
94
8
39
2.16
1.19
1.0
1.1
—
—
—
0
0
7
30
2.45
1.15
26.3
12.3
95.1
94.9
%
—
7
30
13
76
1.84
1.06
2.8
1.5
—
—
—
0
0
7
34
2.15
1.05
20.9
6.6
26.3
25.0
mmol/l
—
7
34
13
77
1.81
1.02
2.7
2.6
5.8
9.0
umol/l
0.56
13
66
17
111
1.66
0.97
6.2
2.9
0.8
0.8
mmol/l
0.21
17
103
18
120
1.63
0.95
1.4
1.7
—
—
—
0
0
44
360
1.46
0.92
8.7
5.8
1.7
1.8
e9/l
0.78
36
328
13
80
1.74
0.91
1.5
1.5
—
—
—
0
0
12
73
1.75
0.87
1.9
1.7
—
—
—
0
0
49
413
1.43
0.85
12.1
9.5
3.3
4.1
e9/l
2.08
43
360
0
25
0.00
0.80
0.0
1.6
—
—
—
0
0
42
347
1.41
0.80
8.9
5.8
0.5
0.6
e9/l
1.73
36
310
42
347
1.41
0.80
8.9
5.9
0.0
0.0
e9/l
0.12
36
312
10
59
1.79
0.79
1.9
1.6
—
—
—
0
0
5
24
2.15
0.76
4.0
2.2
1.3
1.2
%
—
5
24
79
741
1.81
0.74
14.2
11.4
—
—
—
0
0
79
741
1.81
0.74
21.3
14.4
78.2
78.1
umol/l
0.02
79
741
5
28
1.83
0.67
24.4
9.0
—
—
—
0
0
5
28
1.83
0.67
4.0
2.0
—
—
—
0
0
52
458
1.34
0.61
5.0
4.0
—
—
—
0
0
21
160
1.41
0.61
4.8
5.1
—
—
—
0
0
24
189
1.37
0.58
10.2
6.5
—
—
—
0
0
6
37
1.67
0.57
1.5
1.2
—
—
—
0
0
75
704
1.51
0.56
18.5
12.5
27.4
22.4
mg/l
0.51
58
554
12
85
1.48
0.50
3.4
2.1
144.6
116.3
ug/g
—
7
68
47
523
0.78
0.50
5.5
3.6
8.8
11.1
mm/h
0.72
47
481
52
467
1.29
0.49
3.6
3.4
—
—
—
0
0
30
251
1.30
0.48
6.7
6.8
1.0
1.2
inr
—
10
76
12
160
0.71
0.45
1.5
1.3
2.2
2.7
g/l
—
7
98
0
15
0.00
0.41
0.0
1.6
—
—
—
0
0
22
181
1.29
0.40
3.6
3.5
0.0
0.0
estimate
—
7
58
9
67
1.38
0.39
30.7
15.9
—
1.3
—
0
8
0
19
0.00
0.39
0.0
10.0
—
—
—
0
0
10
72
1.44
0.39
1.7
1.4
—
—
—
0
0
38
336
1.23
0.38
3.8
3.5
0.0
0.0
estimate
—
7
60
27
232
1.24
0.34
4.8
4.3
2.2
1.7
ug/l
0.79
22
208
7
96
0.71
0.33
1.3
1.3
—
—
—
0
0
7
54
1.32
0.31
5.3
4.3
—
—
—
0
0
8
66
1.23
0.27
3.9
2.7
273.4
372.3
nmol/l
—
8
58
5
39
1.30
0.23
5.0
5.1
4.4
4.6
pmol/l
—
5
34
31
281
1.16
0.22
2.8
2.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
1.5
—
0
10
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
36
331
1.15
0.21
5.7
4.9
0.0
0.0
estimate
—
8
61
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
0
14
0.00
0.20
0.0
5.2
—
—
—
0
0
6
51
1.19
0.20
8.7
3.7
—
—
—
0
0
36
333
1.14
0.19
3.8
3.5
0.0
0.0
estimate
—
8
62
16
177
0.88
0.11
3.2
2.8
—
—
—
0
0
5
46
1.09
0.10
2.2
2.2
21.5
5.6
ug/l
—
5
41
22
236
0.91
0.09
2.1
2.0
96.2
97.5
pmol/l
—
9
115
17
185
0.90
0.09
5.2
3.2
246.7
83.5
mg/l
0.46
12
129
7
65
1.08
0.08
1.3
1.2
—
—
—
0
0
7
84
0.82
0.07
1.3
1.4
—
—
—
0
0
17
161
1.07
0.03
3.4
3.3
—
—
—
0
0
69
681
1.07
0.03
4.0
4.3
1.4
1.4
mmol/l
0.17
64
636
19
199
0.94
0.03
7.5
3.8
37.6
12.6
mg/mmol
0.39
13
135
67
661
1.06
0.03
3.4
3.9
1.2
1.4
mmol/l
1.13
62
614
18
188
0.95
0.02
4.4
3.1
—
—
—
0
0
15
157
0.95
0.01
3.5
3.5
—
—
—
0
0
23
235
0.97
0.00
2.9
3.1
23.6
40.1
ng/l
0.67
17
145
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
88.7
—
0
8
0
8
0.00
0.00
0.0
2.1
—
7.5
—
0
8
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
4.7
—
0.6
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
7
78
0.89
0.00
1.3
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
2.7
—
12.0
—
0
7
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
11.4
—
1423.0
—
0
5
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
5
52
0.96
0.00
1.6
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
246.6
—
0
7
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
6.8
—
922.0
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
6.2
—
0
5
0
7
0.00
0.00
0.0
3.6
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_MALARIA_NOS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have AB1_MALARIA_NOS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: AB1_MALARIA_NOS – Other parasitologically confirmed or unspecified malaria

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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