No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
186 |
6. Filter based on genotype QC (FinnGen only) |
171 |
Control definitions (FinnGen only)
- Control exclude
- AB1_PROTOZOAL
Extra metadata
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Malaria
based on the number of shared cases.
Similar with more cases:
- Protozoal diseases
- Certain infectious and parasitic diseases
- Certain infectious and parasitic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2110 | 834 | 1215 |
| Only index persons | 1820 | 733 | 1087 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.02 | 0.03 |
| Only index persons | 0.04 | 0.03 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 35.94 | 35.12 | 36.67 |
| Only index persons | 35.61 | 34.39 | 36.42 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 171 | 86 | 85 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.04 |
| Median age at first event (years) | 37.94 | 34.74 | 41.18 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 186
- Matched controls
- 1860
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
B50.9
ICD-10 Finland
Plasmodium falciparum malaria, unspecified
+∞
59.6
54
*
B54
ICD-10 Finland
Unspecified malaria
+∞
58.5
53
*
0840A
ICD-9 Finland
Malaria, Falciparum malaria [malignant tertian]
+∞
16.9
16
*
R50.9
ICD-10 Finland
Fever, unspecified
3.2
9.7
45
167
08410
ICD-8 Finland
Vivax malaria (benign tertian)
+∞
9.5
9
*
B51.9
ICD-10 Finland
Plasmodium vivax malaria without complication
+∞
9.5
9
*
08400
ICD-8 Finland
Falicparum malaria (malignant tertian)
+∞
8.4
8
*
B50.0
ICD-10 Finland
Plasmodium falciparum malaria with cerebral complications
+∞
8.4
8
*
0846X
ICD-9 Finland
Malaria, unspecified
+∞
7.3
7
*
B53.0
ICD-10 Finland
Plasmodium ovale malaria
+∞
6.3
6
*
08499
ICD-8 Finland
Malaria, Unspecified forms
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
75
503
1.82
3.75
3.6
3.0
—
—
—
0
0
29
139
2.29
3.68
1.9
2.2
28.48
34.45
u/l
0.56
21
119
73
499
1.76
3.35
3.8
3.1
28.03
30.95
u/l
0.80
67
473
61
408
1.74
2.97
3.4
2.9
0.34
0.50
e6/l
0.47
49
307
9
24
3.89
2.71
2.2
1.9
—
—
—
0
0
9
24
3.89
2.71
2.2
1.9
—
—
—
0
0
10
36
2.88
2.17
2.1
1.7
—
—
—
0
0
7
19
3.78
2.17
1.4
1.2
—
—
—
0
0
6
14
4.39
2.17
2.3
2.0
—
—
—
0
0
5
10
5.10
2.08
2.2
1.3
—
—
—
0
0
30
181
1.78
2.04
2.0
2.0
—
—
—
0
0
48
331
1.61
2.01
2.8
2.3
—
—
—
0
0
6
16
3.84
1.95
1.2
1.9
—
—
—
0
0
6
16
3.84
1.95
1.2
1.9
—
—
—
0
0
6
16
3.84
1.95
1.2
1.9
—
—
—
0
0
6
16
3.84
1.95
2.7
1.6
—
—
—
0
0
6
16
3.84
1.95
2.7
1.6
—
—
—
0
0
39
260
1.63
1.86
3.0
3.1
693.48
111.64
ng/l
0.61
27
187
6
17
3.61
1.85
2.3
1.8
—
—
—
0
0
11
47
2.42
1.81
2.4
1.7
—
—
—
0
0
31
200
1.66
1.68
2.6
2.1
—
—
—
0
0
5
14
3.64
1.62
2.6
1.3
—
—
—
0
0
33
219
1.62
1.61
3.4
2.8
2.23
2.02
e6/l
0.07
19
113
35
238
1.58
1.54
3.0
2.7
0.63
0.93
e6/l
0.43
20
132
5
15
3.39
1.53
1.6
1.2
—
—
—
0
0
6
21
2.92
1.52
1.8
1.6
—
—
—
0
0
74
590
1.42
1.51
7.7
4.6
36.50
36.00
g/l
0.34
69
558
5
16
3.18
1.44
1.6
1.3
—
—
—
0
0
28
184
1.61
1.42
1.5
1.8
1.50
1.49
%
0.03
23
162
53
402
1.45
1.40
1.7
1.6
1.26
1.44
mmol/l
1.38
44
341
102
868
1.39
1.40
12.2
9.6
3.57
4.13
e9/l
2.15
87
761
32
219
1.56
1.38
2.2
1.9
—
—
—
0
0
5
17
2.99
1.36
1.0
1.1
—
—
—
0
0
154
1412
1.53
1.36
17.3
12.0
82.34
84.64
ml/min/173m2
0.56
125
1147
127
1126
1.40
1.33
11.3
7.6
74.08
75.79
u/l
0.25
118
1063
6
24
2.55
1.31
2.0
1.4
—
—
—
0
0
8
36
2.28
1.26
2.6
1.6
—
—
—
0
0
6
25
2.45
1.25
2.3
1.6
—
—
—
0
0
9
45
2.05
1.25
1.9
1.6
92.11
92.53
%
—
9
45
5
19
2.67
1.22
2.4
2.1
—
—
—
0
0
33
237
1.48
1.15
5.4
3.6
0.85
0.82
mmol/l
0.42
33
225
17
104
1.70
1.14
2.8
1.9
—
—
—
0
0
8
40
2.04
1.13
1.4
1.5
—
—
—
0
0
7
31
2.31
1.11
1.4
1.5
—
—
—
0
0
9
46
2.00
1.05
1.9
2.3
—
—
—
0
0
5
22
2.31
1.04
9.8
3.0
44.62
16.20
u/ml
—
5
22
115
1026
1.32
1.02
3.4
3.2
—
—
—
0
0
89
767
1.31
1.02
10.1
6.5
10.23
10.79
umol/l
0.43
83
735
79
671
1.31
1.00
3.4
2.6
—
—
—
0
0
25
175
1.50
0.99
2.2
3.0
5.60
9.03
umol/l
1.19
20
149
7
36
1.98
0.98
1.4
1.2
—
—
—
0
0
14
85
1.70
0.97
2.4
1.9
—
—
—
0
0
41
317
1.38
0.97
2.8
1.9
3.46
2.99
mg/l
0.35
34
278
6
27
2.26
0.94
4.0
3.6
54.83
60.41
%
—
6
27
6
28
2.18
0.92
1.2
1.1
—
—
—
0
0
6
28
2.18
0.92
1.2
1.5
—
—
—
0
0
6
28
2.18
0.92
1.2
1.5
—
—
—
0
0
16
103
1.61
0.91
1.5
2.8
68.80
66.48
ml/min/173m2
—
5
42
77
659
1.29
0.91
8.1
7.2
1.22
1.21
mmol/l
0.35
68
565
8
42
1.94
0.90
1.6
2.0
—
—
—
0
0
62
517
1.30
0.89
2.1
1.9
97.16
95.31
pmol/l
0.13
31
260
73
623
1.28
0.87
14.3
10.8
1.27
1.21
inr
0.20
25
193
22
155
1.48
0.86
2.0
1.8
—
—
—
0
0
168
1605
1.48
0.82
13.3
9.8
25.19
27.23
u/l
1.06
161
1553
8
48
1.70
0.80
2.6
3.1
—
—
—
0
0
22
159
1.44
0.76
2.2
1.8
—
—
—
0
0
66
565
1.26
0.76
2.7
2.4
78.18
74.03
nmol/l
0.60
61
502
7
40
1.78
0.72
1.1
1.2
—
—
—
0
0
5
26
1.95
0.71
1.2
1.2
—
1.70
—
0
10
7
42
1.69
0.69
1.1
1.4
—
—
—
0
0
12
80
1.53
0.61
13.0
5.4
25.28
24.76
mmol/l
0.28
12
80
80
714
1.21
0.61
3.5
3.4
0.00
0.00
estimate
-0.00
14
137
115
1063
1.21
0.60
3.3
3.0
45.87
48.11
u/l
0.11
104
1003
157
1500
1.30
0.60
17.8
13.2
24.49
23.75
mg/l
0.09
122
1178
28
221
1.31
0.60
1.7
1.7
1025.43
1280.14
nmol/l
0.90
21
169
15
106
1.45
0.60
1.6
1.5
—
—
—
0
0
71
628
1.21
0.59
3.5
2.7
120.90
114.78
ug/l
0.08
64
585
6
35
1.74
0.58
1.2
1.2
—
—
—
0
0
173
1678
1.44
0.57
25.5
19.1
40.33
40.58
%
0.31
165
1588
6
37
1.64
0.56
1.3
1.4
—
2.18
—
0
6
12
82
1.50
0.56
4.3
3.5
4.98
5.16
kpa
0.52
12
77
37
308
1.25
0.54
2.6
3.0
0.68
0.73
ug/l
0.28
31
192
173
1681
1.42
0.53
25.2
19.1
134.28
136.94
g/l
1.44
173
1655
78
703
1.19
0.52
3.5
3.4
0.00
0.01
estimate
0.50
16
152
78
705
1.18
0.50
4.9
4.7
0.00
0.00
estimate
-0.00
16
145
31
372
0.80
0.49
3.4
2.9
712.96
952.74
ng/l
0.50
25
302
7
45
1.58
0.49
1.0
1.2
—
—
—
0
0
45
387
1.21
0.49
3.6
3.6
0.00
0.01
estimate
0.50
15
137
7
48
1.48
0.47
1.4
1.2
—
—
—
0
0
7
48
1.48
0.47
1.7
1.9
—
—
—
0
0
11
77
1.46
0.46
4.4
3.6
0.62
1.61
mmol/l
—
6
61
149
1428
1.22
0.46
3.9
3.8
1.21
1.33
mmol/l
1.46
135
1320
154
1482
1.23
0.44
4.5
4.2
4.64
4.70
mmol/l
0.34
144
1386
8
59
1.37
0.41
7.0
1.2
—
—
—
0
0
0
17
0.00
0.41
0.0
2.5
—
13.50
—
0
17
0
17
0.00
0.41
0.0
1.0
—
—
—
0
0
141
1356
1.16
0.35
4.8
4.5
1.89
1.86
mu/l
0.10
127
1243
6
44
1.38
0.35
1.2
1.8
—
—
—
0
0
31
269
1.18
0.32
2.3
1.7
490.42
470.22
pmol/l
0.14
26
235
46
413
1.15
0.31
4.0
4.4
19.37
20.66
%
0.26
26
192
20
166
1.23
0.31
14.5
6.6
104.65
103.74
mmol/l
0.51
20
166
10
76
1.33
0.28
2.3
1.2
—
—
—
0
0
10
76
1.33
0.28
1.9
1.8
—
—
—
0
0
18
150
1.22
0.27
4.3
3.0
—
—
—
0
0
154
1500
1.16
0.27
4.7
4.6
2.78
2.80
mmol/l
0.10
146
1395
57
526
1.12
0.26
4.7
4.7
2.48
2.59
ug/l
0.05
51
470
147
1429
1.14
0.26
4.7
4.1
5.96
5.91
mmol/l
0.13
131
1309
9
74
1.23
0.25
1.3
1.3
—
—
—
0
0
12
147
0.80
0.24
4.7
6.9
—
—
—
0
0
51
551
0.90
0.23
3.7
3.5
—
—
—
0
0
15
178
0.83
0.23
1.3
1.7
—
—
—
0
0
5
39
1.29
0.23
1.4
1.3
—
—
—
0
0
36
326
1.13
0.22
1.5
1.5
22.51
21.75
nmol/l
0.12
29
272
5
42
1.20
0.21
1.6
1.2
—
—
—
0
0
5
42
1.20
0.21
1.6
1.2
—
—
—
0
0
5
42
1.20
0.21
11.2
4.3
—
3.46
—
0
7
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
109.39
—
0
10
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
3.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
2.3
—
—
—
0
0
6
52
1.16
0.19
1.3
1.5
—
—
—
0
0
39
360
1.11
0.18
3.5
2.6
362.50
9438.79
umol/l
2.17
30
318
56
528
1.09
0.17
3.5
3.5
53.60
36.33
ng/l
0.23
40
345
6
79
0.75
0.16
1.0
1.0
—
—
—
0
0
139
1362
1.08
0.14
6.2
5.1
38.92
39.56
mmol/mol
0.35
131
1283
16
141
1.15
0.14
12.7
10.7
5.07
5.05
kpa
0.03
16
136
16
141
1.15
0.14
12.7
10.7
13.73
12.74
kpa
0.31
16
136
150
1476
1.08
0.13
4.4
4.2
1.44
1.45
mmol/l
0.13
138
1373
22
240
0.91
0.12
1.2
1.3
1.00
9.45
u/ml
—
5
93
14
157
0.88
0.11
4.9
4.2
34.33
31.58
%
—
9
106
5
47
1.07
0.09
1.4
1.3
—
—
—
0
0
5
48
1.04
0.09
1.4
1.3
—
—
—
0
0
5
48
1.04
0.09
1.4
1.3
—
—
—
0
0
6
57
1.05
0.08
1.8
1.6
31.36
4.32
mg/l
—
6
35
6
71
0.84
0.08
3.7
2.3
1.07
1.24
%
—
6
71
41
394
1.05
0.07
6.3
3.8
21.13
10.54
mg/mmol
0.32
26
268
111
1097
1.03
0.04
4.5
3.8
10.96
10.88
mm/h
0.02
105
1014
30
290
1.04
0.03
1.5
1.5
—
—
—
0
0
11
102
1.08
0.03
3.5
4.1
100.36
82.58
ng/l
0.16
11
91
26
252
1.04
0.02
1.3
1.2
38.03
30.82
iu/ml
—
7
86
10
107
0.93
0.02
1.6
2.3
11.95
9.34
ug/l
—
10
98
23
233
0.99
0.00
1.4
1.4
—
—
—
0
0
110
1097
1.01
0.00
4.4
3.9
14.36
14.73
pmol/l
0.92
96
1010
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
11.02
—
0
6
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
26.83
—
0
7
0
6
0.00
-0.00
0.0
3.0
—
—
—
0
0
8
83
0.96
-0.00
1.3
1.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint AB1_MALARIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_MALARIA | 2.107 [1.54, 2.88] | < 0.001 |
| Birth year | 1.002 [0.99, 1.01] | 0.702 |
During the follow-up period (1.1.1998 — 31.12.2019), 94 out of 611 females with AB1_MALARIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_MALARIA | 1.356 [1.05, 1.74] | 0.018 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 85 out of 823 males with AB1_MALARIA died.
Mortality risk
Mortality risk for people of age
years, who have AB1_MALARIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.239% | 0.241% |
| 5 | 1.427% | 1.494% |
| 10 | 3.723% | 3.803% |
| 15 | 7.009% | 7.091% |
| 20 | 12.556% | 12.263% |
Relationships between endpoints
↥Index endpoint: AB1_MALARIA – Malaria
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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