Malaria

AB1_MALARIA

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

185

6. Filter based on genotype QC (FinnGen only)

185

Control definitions (FinnGen only)

Control exclude
AB1_PROTOZOAL

Extra metadata

First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2110 834 1215
Only index persons 1820 733 1087
Unadjusted period prevalence (%)
Whole population 0.03 0.02 0.03
Only index persons 0.04 0.03 0.04
Median age at first event (years)
Whole population 35.94 35.12 36.67
Only index persons 35.61 34.39 36.42

-FinnGen-

Key figures

All Female Male
Number of individuals 185 89 96
Unadjusted period prevalence (%) 0.04 0.03 0.04
Median age at first event (years) 37.88 34.30 41.21

-FinRegistry-

Age distribution of first events

0102030405060708090050100150200250300350400450AgeIndividuals

-FinnGen-

Age distribution of first events

01020304050607090051015202530354045AgeIndividuals

-FinRegistry-

Year distribution of first events

197019751980198519901995200020052010201520202022050100150200250300350400YearIndividuals

-FinnGen-

Year distribution of first events

19701975198019851990199520002005201020152023051015202530YearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000.00.10.20.30.40.50.60.70.80.91.0AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
164
Matched controls
1640
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
B50.9
ICD-10 Finland
Plasmodium falciparum malaria, unspecified
+∞
57.8
52
*
B54
ICD-10 Finland
Unspecified malaria
+∞
43.7
40
*
0840A
ICD-9 Finland
Malaria, Falciparum malaria [malignant tertian]
+∞
14.8
14
*
08410
ICD-8 Finland
Vivax malaria (benign tertian)
+∞
9.5
9
*
R50.9
ICD-10 Finland
Fever, unspecified
3.7
8.7
40
131
B50.0
ICD-10 Finland
Plasmodium falciparum malaria with cerebral complications
+∞
7.3
7
*
B51.9
ICD-10 Finland
Plasmodium vivax malaria without complication
+∞
7.3
7
*
08400
ICD-8 Finland
Falicparum malaria (malignant tertian)
+∞
6.3
6
*
08499
ICD-8 Finland
Malaria, Unspecified forms
+∞
6.3
6
*
B53.0
ICD-10 Finland
Plasmodium ovale malaria
+∞
6.3
6
*
0846X
ICD-9 Finland
Malaria, unspecified
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
82
521
2.03
5.18
3.9
3.4
17.30
116.46
e6/l
1.21
59
370
74
464
1.99
4.77
7.5
5.9
—
—
—
0
0
70
455
1.87
3.91
3.4
2.9
12.19
54.71
e6/l
1.95
58
350
50
291
1.98
3.87
2.9
2.4
580.95
583.20
mosm/kgh2o
0.02
42
247
29
137
2.32
3.80
1.9
2.2
28.48
33.53
u/l
0.45
21
118
63
404
1.85
3.63
3.2
2.8
—
—
—
0
0
61
389
1.85
3.56
1.6
1.5
—
—
—
0
0
51
326
1.78
2.89
2.0
1.9
—
—
—
0
0
60
406
1.71
2.78
3.4
2.9
0.35
0.51
e6/l
0.45
48
304
48
309
1.75
2.64
2.8
2.4
4.91
6.73
e6/l
0.25
43
279
30
169
1.93
2.51
1.6
1.6
—
—
—
0
0
87
670
1.56
2.32
8.2
5.9
0.69
0.68
%
0.11
80
621
21
108
2.07
2.26
1.9
1.6
—
—
—
0
0
88
687
1.54
2.17
8.1
5.9
2.66
2.82
%
0.31
81
640
94
746
1.53
2.14
8.8
6.4
0.17
0.19
e9/l
0.76
81
670
88
691
1.52
2.09
8.3
6.2
8.99
8.48
%
0.77
81
648
86
673
1.52
2.07
11.8
9.2
0.00
0.00
e9/l
0.52
70
551
29
173
1.80
2.05
1.4
1.3
—
—
—
0
0
156
1398
1.74
2.01
17.8
13.1
40.35
40.47
%
0.08
115
1081
93
744
1.50
1.99
8.1
6.1
1.81
1.81
e9/l
0.00
76
671
29
175
1.78
1.97
2.2
1.7
—
—
—
0
0
91
728
1.49
1.93
8.2
6.1
0.54
0.57
e9/l
0.81
75
639
39
258
1.65
1.92
3.0
3.0
719.50
124.32
ng/l
0.60
26
185
91
729
1.49
1.92
8.2
6.1
0.04
0.04
e9/l
0.31
75
641
89
710
1.49
1.91
8.2
6.0
30.40
27.56
%
1.38
82
665
28
170
1.76
1.87
1.8
1.7
—
—
—
0
0
87
696
1.47
1.82
7.9
5.8
55.20
57.47
%
0.87
80
652
72
559
1.47
1.73
2.9
2.0
—
—
—
0
0
114
971
1.45
1.67
4.9
3.9
—
—
—
0
0
21
122
1.81
1.63
1.5
1.4
—
—
—
0
0
33
219
1.62
1.61
3.4
2.8
2.23
2.05
e6/l
0.06
19
113
27
170
1.69
1.60
2.0
1.4
—
—
—
0
0
74
591
1.42
1.50
7.7
4.3
36.34
35.93
g/l
0.28
68
555
5
16
3.18
1.44
2.4
2.2
—
544.33
—
0
6
5
16
3.18
1.44
1.6
1.8
—
—
—
0
0
53
401
1.45
1.43
1.7
1.6
1.26
1.43
mmol/l
1.28
44
338
13
67
2.01
1.42
1.0
1.1
—
—
—
0
0
51
385
1.45
1.39
9.4
6.4
—
—
—
0
0
5
17
2.99
1.36
3.0
1.6
—
—
—
0
0
5
17
2.99
1.36
3.0
1.6
—
—
—
0
0
5
17
2.99
1.36
3.0
1.6
—
—
—
0
0
5
17
2.99
1.36
3.0
1.6
—
—
—
0
0
19
114
1.74
1.34
3.8
4.9
1.00
0.39
%
—
7
31
24
154
1.64
1.34
26.3
18.6
2.02
1.20
inr
—
5
24
10
188
0.51
1.29
1.4
1.4
—
—
—
0
0
57
447
1.40
1.25
2.9
2.2
—
—
—
0
0
5
19
2.67
1.22
2.4
2.1
—
—
—
0
0
116
1023
1.36
1.20
3.6
3.6
—
—
—
0
0
50
386
1.40
1.20
4.7
4.2
—
—
—
0
0
11
57
1.99
1.19
3.1
2.1
—
—
—
0
0
100
864
1.34
1.17
12.4
9.6
3.55
4.14
e9/l
2.30
85
757
125
1123
1.35
1.10
11.4
7.5
74.05
75.68
u/l
0.23
117
1058
53
422
1.36
1.05
5.1
3.6
7.40
7.40
ph
—
8
83
5
22
2.31
1.04
1.8
1.9
—
—
—
0
0
5
22
2.31
1.04
1.0
1.1
—
—
—
0
0
5
22
2.31
1.04
9.8
3.0
44.62
16.20
u/ml
—
5
22
29
208
1.47
1.02
2.5
2.0
—
—
—
0
0
25
174
1.51
1.02
2.2
2.8
5.60
8.96
umol/l
1.15
20
148
5
23
2.21
0.98
1.2
1.2
—
—
—
0
0
7
36
1.98
0.98
1.0
1.2
—
—
—
0
0
41
317
1.38
0.97
2.8
1.9
3.46
2.99
mg/l
0.34
34
278
33
246
1.42
0.96
1.5
1.6
—
—
—
0
0
18
118
1.58
0.95
5.2
4.9
0.33
0.24
%
—
9
38
77
656
1.30
0.95
8.1
6.3
1.22
1.21
mmol/l
0.28
67
559
72
608
1.30
0.95
8.7
5.1
1.22
1.21
mmol/l
0.10
67
556
6
27
2.26
0.94
4.0
3.6
54.83
60.41
%
—
6
27
88
765
1.29
0.92
10.2
6.3
10.21
10.83
umol/l
0.48
82
733
62
516
1.30
0.90
2.1
1.9
97.16
95.11
pmol/l
0.15
31
261
11
64
1.76
0.88
1.4
1.2
—
—
—
0
0
6
30
2.03
0.87
2.2
2.2
4.95
4.91
kpa
—
6
30
6
30
2.03
0.87
2.2
2.2
7.95
8.96
kpa
—
6
30
23
163
1.47
0.87
1.7
1.7
—
—
—
0
0
167
1596
1.48
0.80
13.4
9.7
25.10
27.17
u/l
1.08
160
1543
0
24
0.00
0.80
0.0
1.0
—
—
—
0
0
5
24
2.11
0.75
1.0
1.3
—
—
—
0
0
16
109
1.51
0.74
3.8
2.5
90.67
70.46
e9/l
—
10
81
72
625
1.25
0.73
3.5
2.7
125.75
115.31
ug/l
0.15
65
582
165
1579
1.42
0.72
20.6
14.9
79.53
77.41
umol/l
0.44
165
1579
9
57
1.61
0.72
1.3
1.5
—
—
—
0
0
23
170
1.40
0.72
4.3
2.5
165.29
100.47
ug/g
0.69
14
135
18
129
1.44
0.66
5.2
4.7
1.00
1.02
%
—
9
44
12
79
1.55
0.64
13.0
5.0
25.28
24.81
mmol/l
0.25
12
79
156
1490
1.30
0.60
17.9
13.0
24.06
23.62
mg/l
0.05
121
1171
28
222
1.31
0.58
1.7
1.7
1025.43
1279.99
nmol/l
0.90
21
168
149
1418
1.26
0.57
3.9
3.8
1.23
1.33
mmol/l
1.22
135
1310
154
1472
1.28
0.56
4.5
4.2
4.64
4.69
mmol/l
0.31
144
1375
79
709
1.20
0.56
3.5
3.5
0.00
0.00
estimate
0.00
14
138
6
38
1.60
0.55
1.5
1.2
—
—
—
0
0
15
109
1.41
0.53
6.1
5.1
0.29
0.28
%
—
7
32
13
178
0.71
0.51
1.5
1.4
—
—
—
0
0
172
1672
1.41
0.51
25.3
18.9
134.00
136.82
g/l
1.59
172
1645
26
320
0.78
0.51
1.7
1.3
1.96
2.52
g/l
1.17
15
190
37
310
1.24
0.51
2.6
3.1
0.68
0.76
ug/l
0.45
31
196
15
110
1.40
0.50
11.9
6.5
—
—
—
0
0
77
695
1.18
0.50
3.5
3.4
0.00
0.00
estimate
0.00
16
144
60
531
1.19
0.49
7.1
7.2
1.07
1.20
inr
1.99
21
166
13
94
1.41
0.47
4.9
2.6
—
—
—
0
0
77
700
1.17
0.45
4.9
4.7
0.00
0.00
estimate
0.00
16
146
141
1347
1.20
0.44
4.8
4.5
1.89
1.85
mu/l
0.13
127
1232
24
291
0.80
0.42
2.7
3.7
1.02
1.02
kg/l
—
5
36
32
270
1.22
0.42
2.3
1.7
482.67
468.91
pmol/l
0.10
27
236
8
60
1.35
0.41
3.6
3.7
—
—
—
0
0
7
102
0.67
0.41
1.9
1.3
—
—
—
0
0
7
102
0.67
0.41
4.1
3.3
—
—
—
0
0
44
386
1.18
0.39
3.7
3.6
0.00
0.01
estimate
0.50
15
138
5
36
1.40
0.38
1.2
1.8
—
—
—
0
0
154
1491
1.20
0.36
4.8
4.6
2.77
2.79
mmol/l
0.11
146
1383
6
42
1.44
0.36
1.8
1.6
—
—
—
0
0
6
42
1.44
0.36
1.0
1.2
—
—
—
0
0
6
44
1.38
0.35
1.0
1.4
—
—
—
0
0
37
325
1.17
0.33
1.5
1.5
22.36
21.71
nmol/l
0.10
30
271
16
129
1.26
0.31
1.1
1.2
—
—
—
0
0
58
531
1.13
0.30
4.7
4.8
2.46
2.61
ug/l
0.08
52
474
8
63
1.28
0.28
15.8
6.5
—
—
—
0
0
40
360
1.14
0.27
3.4
2.6
366.45
9495.47
umol/l
2.16
31
316
5
75
0.66
0.26
17.4
7.3
24.50
23.76
mmol/l
—
5
70
19
161
1.20
0.25
1.5
1.4
—
—
—
0
0
146
1421
1.13
0.24
4.7
4.1
5.97
5.91
mmol/l
0.15
131
1302
5
37
1.36
0.23
1.0
1.1
—
—
—
0
0
15
125
1.22
0.23
6.4
3.4
—
—
—
0
0
5
41
1.23
0.22
1.6
1.2
—
—
—
0
0
5
41
1.23
0.22
1.4
1.3
—
—
—
0
0
5
42
1.20
0.21
1.4
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
3234.00
—
0
5
0
10
0.00
0.21
0.0
1.1
—
259.70
—
0
10
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
5
43
1.17
0.21
1.4
1.5
—
—
—
0
0
5
43
1.17
0.21
1.0
1.1
—
—
—
0
0
10
123
0.80
0.21
1.1
1.5
—
—
—
0
0
150
1466
1.12
0.21
4.4
4.2
1.43
1.45
mmol/l
0.18
138
1362
0
13
0.00
0.21
0.0
1.9
—
12.22
—
0
13
10
81
1.25
0.19
1.4
1.2
—
—
—
0
0
15
129
1.18
0.17
3.1
3.4
—
—
—
0
0
5
67
0.74
0.17
1.2
1.3
—
—
—
0
0
5
68
0.73
0.17
1.2
1.3
—
—
—
0
0
5
68
0.73
0.17
1.2
1.3
—
—
—
0
0
35
322
1.11
0.17
3.3
3.5
—
—
—
0
0
56
529
1.08
0.16
3.5
3.5
53.63
38.71
ng/l
0.19
40
345
10
83
1.22
0.16
1.1
1.1
—
—
—
0
0
16
140
1.16
0.15
12.7
6.2
5.07
5.05
kpa
0.03
16
135
16
140
1.16
0.15
12.7
6.2
13.73
12.78
kpa
0.29
16
135
17
192
0.87
0.15
1.5
1.3
—
—
—
0
0
9
79
1.15
0.15
5.9
4.4
—
—
—
0
0
40
374
1.09
0.14
4.8
3.2
118.56
219.98
mg/l
0.25
28
259
42
394
1.09
0.14
6.7
3.9
21.13
10.19
mg/mmol
0.34
26
268
39
365
1.09
0.14
3.8
3.6
—
—
—
0
0
138
1355
1.07
0.12
6.3
5.2
38.97
39.62
mmol/mol
0.35
130
1276
15
168
0.88
0.12
1.8
1.3
—
—
—
0
0
11
126
0.86
0.11
17.5
6.4
97.76
96.04
%
1.46
11
121
22
238
0.91
0.10
1.2
1.3
1.00
9.54
u/ml
—
5
92
59
611
0.95
0.09
3.6
2.7
—
—
—
0
0
6
70
0.85
0.08
3.7
2.3
1.07
1.25
%
—
6
70
111
1091
1.04
0.07
4.4
3.9
14.34
14.73
pmol/l
1.00
97
1004
11
99
1.12
0.06
1.1
1.2
—
54.76
—
0
7
36
346
1.05
0.06
5.8
5.2
—
—
—
0
0
11
100
1.11
0.05
3.5
4.1
100.36
81.71
ng/l
0.17
11
89
42
408
1.04
0.04
4.7
3.0
7.22
8.13
mmol/l
0.69
35
341
10
92
1.09
0.03
1.8
2.2
—
—
—
0
0
26
251
1.04
0.03
1.3
1.2
38.03
31.11
iu/ml
—
7
85
41
403
1.02
0.01
3.6
2.9
—
—
—
0
0
158
1575
1.02
0.00
14.4
11.7
—
—
—
0
0
40
395
1.02
0.00
2.7
2.5
—
—
—
0
0
109
1093
0.99
0.00
4.5
3.8
10.80
10.98
mm/h
0.05
103
1010
11
108
1.02
0.00
6.1
5.1
—
—
—
0
0
10
105
0.95
0.00
1.6
2.4
11.95
8.27
ug/l
—
10
96
0
5
0.00
0.00
0.0
4.6
—
52.00
—
0
5
0
5
0.00
0.00
0.0
2.0
—
0.84
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
6
67
0.89
0.00
4.5
2.9
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
3.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
104.43
—
0
9
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
2.9
—
8.29
—
0
7
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint AB1_MALARIA and mortality.

Females

Parameter HR [95% CI] p-value
AB1_MALARIA 2.107 [1.54, 2.88] < 0.001
Birth year 1.002 [0.99, 1.01] 0.702

During the follow-up period (1.1.1998 — 31.12.2019), 94 out of 611 females with AB1_MALARIA died.

Males

Parameter HR [95% CI] p-value
AB1_MALARIA 1.356 [1.05, 1.74] 0.018
Birth year 0.987 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 85 out of 823 males with AB1_MALARIA died.

Mortality risk

Mortality risk for people of age

years, who have AB1_MALARIA.

N-year risk Females Males
1 0.239% 0.241%
5 1.427% 1.494%
10 3.723% 3.803%
15 7.009% 7.091%
20 12.556% 12.263%

Relationships between endpoints

Index endpoint: AB1_MALARIA – Malaria

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data