Malaria

AB1_MALARIA

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters None 0 out of 7 registries used, show all original rules.	0
4. Check minimum number of events None	0
5. Include endpoints AB1_MALARIA_FALCIPARIUM AB1_MALARIA_VIVAX AB1_MALARIA_MALARIAE AB1_MALARIA_NOS	185
6. Filter based on genotype QC (FinnGen only)	185

Control definitions (FinnGen only)

Control exclude: AB1_PROTOZOAL

Extra metadata

First used in FinnGen datafreeze: DF5

NAME	AB1_MALARIA
CONTROL_EXCLUDE	AB1_PROTOZOAL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	AB1_MALARIA_FALCIPARIUM\|AB1_MALARIA_VIVAX\|AB1_MALARIA_MALARIAE\|AB1_MALARIA_NOS
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Malaria based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	2110	834	1215
Only index persons	1820	733	1087
Unadjusted period prevalence (%)
Whole population	0.03	0.02	0.03
Only index persons	0.04	0.03	0.04
Median age at first event (years)
Whole population	35.94	35.12	36.67
Only index persons	35.61	34.39	36.42

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	185	89	96
Unadjusted period prevalence (%)	0.04	0.03	0.04
Median age at first event (years)	37.88	34.30	41.21

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
164: Matched controls
1640

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

B50.9

ICD-10 Finland

Plasmodium falciparum malaria, unspecified

+∞

57.8

B54

ICD-10 Finland

Unspecified malaria

+∞

43.7

0840A

ICD-9 Finland

Malaria, Falciparum malaria [malignant tertian]

+∞

14.8

08410

ICD-8 Finland

Vivax malaria (benign tertian)

+∞

9.5

R50.9

ICD-10 Finland

Fever, unspecified

3.7

8.7

131

B50.0

ICD-10 Finland

Plasmodium falciparum malaria with cerebral complications

+∞

7.3

B51.9

ICD-10 Finland

Plasmodium vivax malaria without complication

+∞

7.3

08400

ICD-8 Finland

Falicparum malaria (malignant tertian)

+∞

6.3

08499

ICD-8 Finland

Malaria, Unspecified forms

+∞

6.3

B53.0

ICD-10 Finland

Plasmodium ovale malaria

+∞

6.3

0846X

ICD-9 Finland

Malaria, unspecified

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3018095) Leukocytes [#/volume] in Urine

521

2.03

5.18

3.9

3.4

17.3

116.5

e6/l

1.21

370

(42870588) Differential panel, method unspecified - Blood

464

1.99

4.77

7.5

5.9

—

(3002582) Erythrocytes [#/volume] in Urine

455

1.87

3.91

3.4

2.9

12.2

54.7

e6/l

1.95

350

(3026782) Osmolality of Urine

291

1.98

3.87

2.9

2.4

581.0

583.2

mosm/kgh2o

0.02

247

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

137

2.32

3.80

1.9

2.2

28.5

33.5

u/l

0.45

118

(36304419) Bacteria [Presence] in Urine

404

1.85

3.63

3.2

2.8

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

491

1.80

3.59

3.8

3.1

28.0

31.0

u/l

0.84

466

(3003694) ABO and Rh group [Type] in Blood

389

1.85

3.56

1.6

1.5

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

501

1.80

3.56

3.7

3.0

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

326

1.78

2.89

2.0

1.9

—

(3030467) Casts [#/volume] in Urine by Automated count

406

1.71

2.78

3.4

2.9

0.3

0.5

e6/l

0.45

304

(3000850) Epithelial cells [#/volume] in Urine

309

1.75

2.64

2.8

2.4

4.9

6.7

e6/l

0.25

279

(3007853) Bacteria identified in Skin by Aerobe culture

169

1.93

2.51

1.6

—

(3022096) Basophils/100 leukocytes in Blood

670

1.56

2.32

8.2

5.9

0.7

0.11

621

(3021879) Hepatitis B virus core Ab [Presence] in Serum

108

2.07

2.26

1.9

1.6

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

5.67

2.22

2.2

1.2

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

177

1.83

2.19

2.0

—

(3006504) Eosinophils/100 leukocytes in Blood

687

1.54

2.17

8.1

5.9

2.7

2.8

0.31

640

(3013115) Eosinophils [#/volume] in Blood

746

1.53

2.14

8.8

6.4

0.2

e9/l

0.76

670

(3019069) Monocytes/100 leukocytes in Blood

691

1.52

2.09

8.3

6.2

9.0

8.5

0.77

648

(3021589) Normoblasts [#/volume] in Blood

673

1.52

2.07

11.8

9.2

0.0

e9/l

0.52

551

(3002256) Pathology report gross observation

173

1.80

2.05

1.4

1.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

331

1.61

2.01

2.8

2.2

—

(3009542) Hematocrit [Volume Fraction] of Blood

156

1398

1.74

2.01

17.8

13.1

40.4

40.5

0.08

115

1081

(3019198) Lymphocytes [#/volume] in Blood

744

1.50

1.99

8.1

6.1

1.8

e9/l

0.00

671

(3017143) Hepatitis C virus Ab [Presence] in Serum

175

1.78

1.97

2.2

1.7

—

(3001604) Monocytes [#/volume] in Blood

728

1.49

1.93

8.2

6.1

0.5

0.6

e9/l

0.81

639

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

258

1.65

1.92

3.0

719.5

124.3

ng/l

0.60

185

(3006315) Basophils [#/volume] in Blood

729

1.49

1.92

8.2

6.1

0.0

e9/l

0.31

641

(3002030) Lymphocytes/100 leukocytes in Blood

710

1.49

1.91

8.2

6.0

30.4

27.6

1.38

665

(3019832) Treponema pallidum Ab [Presence] in Serum

170

1.76

1.87

1.8

1.7

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

195

1.71

1.84

2.7

2.1

—

(3018010) Neutrophils/100 leukocytes in Blood

696

1.47

1.82

7.9

5.8

55.2

57.5

0.87

652

(40768804) Tissue Pathology biopsy report

559

1.47

1.73

2.9

2.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

114

971

1.45

1.67

4.9

3.9

—

(4035726)

122

1.81

1.63

1.5

1.4

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

3.64

1.62

2.6

2.0

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

219

1.62

1.61

3.4

2.8

2.2

2.0

e6/l

0.06

113

(3000494) Fungus identified in Specimen by Culture

170

1.69

1.60

2.0

1.4

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

3.06

1.59

1.5

1.2

—

(3026389) Candida sp identified in Specimen by Organism specific culture

3.39

1.53

1.6

1.2

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

3.39

1.53

1.0

1.1

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

3.39

1.53

2.6

1.3

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

2.92

1.52

1.8

1.6

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.50

1.50

2.2

1.6

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

591

1.42

1.50

7.7

4.3

36.3

35.9

g/l

0.28

555

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

3.18

1.44

1.6

1.3

—

(3028167) CD3+CD4+ (T4 helper) cells [#/volume] in Blood

3.18

1.44

2.4

2.2

—

544.3

—

(3035637) Corticotropin [Mass/volume] in Plasma

3.18

1.44

1.6

1.8

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

401

1.45

1.43

1.7

1.6

1.3

1.4

mmol/l

1.28

338

(3003327) Ova and parasites identified in Stool by Light microscopy

2.24

1.42

2.5

1.7

—

(1002224) Polysomnography panel

2.01

1.42

1.0

1.1

—

(40758558) Short blood count panel - Blood

385

1.45

1.39

9.4

6.4

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

2.99

1.36

1.2

1.9

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

2.99

1.36

1.2

1.9

—

(44806118)

2.99

1.36

3.0

1.6

—

(44790049)

2.99

1.36

3.0

1.6

—

(44790047)

2.99

1.36

3.0

1.6

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

2.99

1.36

1.2

1.9

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

2.99

1.36

2.6

1.8

—

(44790048)

2.99

1.36

3.0

1.6

—

(3002179) Metamyelocytes/100 leukocytes in Blood

114

1.74

1.34

3.8

4.9

1.0

0.4

—

(3022217) INR in Platelet poor plasma by Coagulation assay

154

1.64

1.34

26.3

18.6

2.0

1.2

inr

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

238

1.53

1.33

3.0

2.7

0.6

0.9

e6/l

0.41

131

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

2.55

1.31

2.0

1.4

—

(21494755) Public health laboratory ask at order entry panel

188

0.51

1.29

1.4

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

2.10

1.29

1.9

1.6

92.1

94.0

—

(3044640) Blood type and Crossmatch panel - Blood

447

1.40

1.25

2.9

2.2

—

(4268621)

2.67

1.22

2.4

2.1

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

183

1.56

1.22

1.5

1.8

1.5

0.19

160

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

217

1.51

1.22

2.2

1.9

—

(3044889) 12 lead EKG panel

116

1023

1.36

1.20

3.6

—

(3023368) Bacteria identified in Blood by Culture

386

1.40

1.20

4.7

4.2

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.99

1.19

3.1

2.1

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

2.35

1.19

2.3

1.6

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

100

864

1.34

1.17

12.4

9.6

3.6

4.1

e9/l

2.30

757

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

103

1.72

1.17

2.8

2.0

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

2.10

1.17

1.4

1.5

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.38

1.13

1.4

1.5

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

125

1123

1.35

1.10

11.4

7.5

74.1

75.7

u/l

0.23

117

1058

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.00

1.05

1.9

2.3

—

(3018418) pH of Serum or Plasma

422

1.36

1.05

5.1

3.6

7.4

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

151

1402

1.42

1.04

17.5

12.0

82.3

84.4

ml/min/173m2

0.51

124

1138

(3025130) Human papilloma virus identified in Specimen

2.31

1.04

1.8

1.9

—

(3044290) Cell count panel - Cerebral spinal fluid

2.31

1.04

1.0

1.1

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

2.31

1.04

9.8

3.0

44.6

16.2

u/ml

—

(3042936) Bacteria identified in Isolate by Culture

208

1.47

1.02

2.5

2.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

670

1.31

1.02

5.2

3.9

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

174

1.51

1.02

2.2

2.8

5.6

9.0

umol/l

1.15

148

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.72

1.01

2.4

1.9

—

(4306422)

2.21

0.98

1.2

—

(40768800) Prostate Pathology biopsy report

1.98

0.98

1.0

1.2

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

1.98

0.98

1.4

1.2

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

317

1.38

0.97

2.8

1.9

3.5

3.0

mg/l

0.34

278

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

246

1.42

0.96

1.5

1.6

—

(3021440) Promyelocytes/100 leukocytes in Blood

118

1.58

0.95

5.2

4.9

0.3

0.2

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

656

1.30

0.95

8.1

6.3

1.2

mmol/l

0.28

559

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

608

1.30

0.95

8.7

5.1

1.2

mmol/l

0.10

556

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

2.26

0.94

4.0

3.6

54.8

60.4

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

765

1.29

0.92

10.2

6.3

10.2

10.8

umol/l

0.48

733

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

2.18

0.92

1.2

1.1

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

113

1015

1.29

0.91

3.4

3.2

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

103

1.61

0.91

1.6

2.8

68.8

66.7

ml/min/173m2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

516

1.30

0.90

2.1

1.9

97.2

95.1

pmol/l

0.15

261

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

2.10

0.90

1.2

1.4

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

2.10

0.90

1.2

1.4

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.94

0.90

1.6

2.0

—

(40768443) Skin Pathology biopsy report

1.76

0.88

1.4

1.2

—

(3013290) Carbon dioxide [Partial pressure] in Blood

2.03

0.87

2.2

5.0

4.9

kpa

—

(3027315) Oxygen [Partial pressure] in Blood

2.03

0.87

2.2

8.0

9.0

kpa

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

163

1.47

0.87

1.7

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

557

1.29

0.86

2.7

2.4

78.2

74.2

nmol/l

0.57

493

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

167

1596

1.48

0.80

13.4

9.7

25.1

27.2

u/l

1.08

160

1543

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.70

0.80

2.6

3.1

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.80

0.0

1.0

—

(3045424) Erythrocytes [Presence] in Urine

2.11

0.75

1.0

1.3

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

1.87

0.74

2.9

1.6

—

(3023520) Reticulocytes [#/volume] in Blood

109

1.51

0.74

3.8

2.5

90.7

70.5

e9/l

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

625

1.25

0.73

3.5

2.7

125.7

115.3

ug/l

0.15

582

(3020564) Creatinine [Moles/volume] in Serum or Plasma

165

1579

1.42

0.72

20.6

14.9

79.5

77.4

umol/l

0.44

165

1579

(3045414) Leukocytes [Presence] in Urine

1.61

0.72

1.3

1.5

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.78

0.72

1.1

1.2

—

(3048689) Calprotectin [Mass/mass] in Stool

170

1.40

0.72

4.3

2.5

165.3

100.5

ug/g

0.69

135

(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay

1.95

0.71

1.2

—

1.7

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

153

1.42

0.71

2.0

1.8

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.73

0.70

1.1

1.4

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

103

1.50

0.67

1.6

1.5

—

(3017181) Myelocytes/100 leukocytes in Blood

129

1.44

0.66

5.2

4.7

1.0

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.61

0.66

1.0

1.2

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.55

0.64

13.0

5.0

25.3

24.8

mmol/l

0.25

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

157

1.38

0.62

2.2

1.8

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

156

1490

1.30

0.60

17.9

13.0

24.1

23.6

mg/l

0.05

121

1171

(3019309) Folate [Moles/volume] in Red Blood Cells

222

1.31

0.58

1.7

1025.4

1280.0

nmol/l

0.90

168

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

1.74

0.58

1.2

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

149

1418

1.26

0.57

3.9

3.8

1.2

1.3

mmol/l

1.22

135

1310

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

154

1472

1.28

0.56

4.5

4.2

4.6

4.7

mmol/l

0.31

144

1375

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

1.64

0.56

1.3

1.4

—

2.2

—

(3009261) Glucose [Presence] in Urine by Test strip

709

1.20

0.56

3.5

0.0

estimate

0.00

138

(40768793) Breast Pathology biopsy report

1.60

0.55

1.5

1.2

—

(3025159) Blasts/100 leukocytes in Blood

109

1.41

0.53

6.1

5.1

0.3

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

113

1052

1.19

0.52

3.3

3.0

46.2

47.8

u/l

0.08

102

994

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

374

0.79

0.52

3.4

2.9

713.0

953.0

ng/l

0.50

304

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

178

0.71

0.51

1.5

1.4

—

(3000963) Hemoglobin [Mass/volume] in Blood

172

1672

1.41

0.51

25.3

18.9

134.0

136.8

g/l

1.59

172

1645

(3007164) IgA [Mass/volume] in Serum or Plasma

320

0.78

0.51

1.7

1.3

2.0

2.5

g/l

1.17

190

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

310

1.24

0.51

2.6

3.1

0.7

0.8

ug/l

0.45

196

(3000991) Gas panel - Venous blood

110

1.40

0.50

11.9

6.5

—

(3035350) Ketones [Presence] in Urine by Test strip

695

1.18

0.50

3.5

3.4

0.0

estimate

0.00

144

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.54

0.49

1.4

1.2

—

(3032080) INR in Blood by Coagulation assay

531

1.19

0.49

7.1

7.2

1.1

1.2

inr

1.99

166

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

1.48

0.47

1.7

1.9

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.41

0.47

4.9

2.6

—

(3021601) Nitrite [Presence] in Urine by Test strip

700

1.17

0.45

4.9

4.7

0.0

estimate

0.00

146

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

141

1347

1.20

0.44

4.8

4.5

1.9

mu/l

0.13

127

1232

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

1.44

0.44

4.4

3.6

0.6

1.6

mmol/l

—

(3019150) Specific gravity of Urine by Refractometry

291

0.80

0.42

2.7

3.7

1.0

kg/l

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

270

1.22

0.42

2.3

1.7

482.7

468.9

pmol/l

0.10

236

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.37

0.41

7.0

1.2

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.41

0.0

1.0

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.41

0.0

2.5

—

13.5

—

(3022313) Gas panel - Capillary blood

1.35

0.41

3.6

3.7

—

(4010399)

102

0.67

0.41

1.9

1.3

—

(40761535) Cells panel - Urine sediment

102

0.67

0.41

4.1

3.3

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

414

1.18

0.40

4.0

4.4

19.4

20.6

0.26

195

(3029937) Albumin [Presence] in Urine by Test strip

386

1.18

0.39

3.7

3.6

0.0

estimate

0.50

138

(3011288) Drugs identified in Urine by Screen method

1.40

0.38

1.2

1.8

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

154

1491

1.20

0.36

4.8

4.6

2.8

mmol/l

0.11

146

1383

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.44

0.36

1.8

1.6

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.44

0.36

1.0

1.2

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.39

0.35

1.9

1.8

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.38

0.35

1.0

1.4

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

1.38

0.35

1.2

1.8

—

(3021960) Folate [Moles/volume] in Serum or Plasma

325

1.17

0.33

1.5

22.4

21.7

nmol/l

0.10

271

(36660697) Celiac disease serology panel - Serum

129

1.26

0.31

1.1

1.2

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.35

0.31

2.3

1.2

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

531

1.13

0.30

4.7

4.8

2.5

2.6

ug/l

0.08

474

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

548

0.88

0.29

3.7

3.5

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.28

0.28

15.8

6.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

150

1.22

0.27

4.3

3.0

—

(3026493) Urate [Moles/volume] in Serum or Plasma

360

1.14

0.27

3.4

2.6

366.5

9495.5

umol/l

2.16

316

(3008152) Bicarbonate [Moles/volume] in Arterial blood

0.66

0.26

17.4

7.3

24.5

23.8

mmol/l

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.24

0.26

1.3

—

(3000492) Spirometry study

161

1.20

0.25

1.5

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

147

0.80

0.24

4.7

6.8

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

146

1421

1.13

0.24

4.7

4.1

6.0

5.9

mmol/l

0.15

131

1302

(4094501)

1.36

0.23

1.0

1.1

—

(40761536) Microorganisms panel - Urine sediment

125

1.22

0.23

6.4

3.4

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.29

0.23

1.4

1.3

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.23

0.22

1.6

1.2

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.23

0.22

1.6

1.2

—

(3005033) Fetal Nuchal fold Thickness US

1.23

0.22

1.4

1.3

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.23

0.22

1.6

1.2

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

1.20

0.21

1.4

1.3

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.21

0.0

1.3

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.1

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.21

0.0

3.0

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

0.21

0.0

1.1

—

(3028308) Erythrocytes [#/volume] in Pleural fluid

0.00

0.21

0.0

1.3

—

3234.0

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.21

0.0

1.7

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.1

—

259.7

—

(3015183) Erythrocyte sedimentation rate

0.00

0.21

0.0

1.1

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.21

0.0

1.3

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

1.17

0.21

1.4

1.5

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

1.17

0.21

11.2

4.4

—

3.5

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

1.17

0.21

1.0

1.1

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

123

0.80

0.21

1.1

1.5

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

150

1466

1.12

0.21

4.4

4.2

1.4

mmol/l

0.18

138

1362

(3011648) Oxygen content in Venous blood

0.00

0.21

0.0

1.9

—

12.2

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.21

0.0

2.3

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.21

0.0

1.2

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

175

0.84

0.19

1.3

1.7

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

1.16

0.19

1.3

1.5

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.25

0.19

1.4

1.2

—

(3012544) pH of Venous blood

129

1.18

0.17

3.1

3.4

—

(3000764) Benzodiazepines [Presence] in Urine

0.74

0.17

1.2

1.3

—

(3027008) Opiates [Presence] in Urine

0.73

0.17

1.2

1.3

—

(3028300) Cannabinoids [Presence] in Urine

0.73

0.17

1.2

1.3

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

322

1.11

0.17

3.3

3.5

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

529

1.08

0.16

3.5

53.6

38.7

ng/l

0.19

345

(3025941) Bacteria identified in Stool by Culture

1.22

0.16

1.1

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.74

0.15

1.0

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

140

1.16

0.15

12.7

6.2

5.1

5.0

kpa

0.03

135

(3027801) Oxygen [Partial pressure] in Arterial blood

140

1.16

0.15

12.7

6.2

13.7

12.8

kpa

0.29

135

(40768797) Stomach Pathology biopsy report

192

0.87

0.15

1.5

1.3

—

(3019060) Gas panel - Arterial blood

1.15

0.15

5.9

4.4

—

(3012516) Albumin [Mass/volume] in Urine

374

1.09

0.14

4.8

3.2

118.6

220.0

mg/l

0.25

259

(3020682) Albumin/Creatinine [Ratio] in Urine

394

1.09

0.14

6.7

3.9

21.1

10.2

mg/mmol

0.34

268

(3013512) EKG study

365

1.09

0.14

3.8

3.6

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

158

0.88

0.12

4.9

4.3

33.8

31.3

—

105

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

138

1355

1.07

0.12

6.3

5.2

39.0

39.6

mmol/mol

0.35

130

1276

(3022145) Colonoscopy Study observation

168

0.88

0.12

1.8

1.3

—

(3016502) Oxygen saturation in Arterial blood

126

0.86

0.11

17.5

6.4

97.8

96.0

1.46

121

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

238

0.91

0.10

1.2

1.3

1.0

9.5

u/ml

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

1.07

0.09

1.4

1.3

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

1.07

0.09

1.4

1.3

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

1.04

0.09

1.4

1.3

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

1.04

0.09

1.4

1.3

—

(1761868) Lipid panel - Serum or Plasma

611

0.95

0.09

3.6

2.7

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

1.05

0.08

1.8

1.6

31.4

4.0

mg/l

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.85

0.08

3.7

2.3

1.1

1.2

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

111

1091

1.04

0.07

4.4

3.9

14.3

14.7

pmol/l

1.00

1004

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

1.12

0.06

1.1

1.2

—

54.8

—

(40760892) CBC W Ordered Manual Differential panel - Blood

346

1.05

0.06

5.8

5.2

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

100

1.11

0.05

3.5

4.1

100.4

81.7

ng/l

0.17

(3009508) Creatinine [Moles/volume] in Urine

408

1.04

0.04

4.7

3.0

7.2

8.1

mmol/l

0.69

341

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

290

1.04

0.03

1.5

—

(3022621) pH of Urine by Test strip

1.09

0.03

1.8

2.2

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

251

1.04

0.03

1.3

1.2

38.0

31.1

iu/ml

—

(3041096) Erythrocytes [Presence] in Urine by Automated

403

1.02

0.01

3.6

2.9

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

233

0.99

0.00

1.4

—

(40761511) CBC panel - Blood by Automated count

158

1575

1.02

0.00

14.4

11.7

—

(3026008) Bacteria identified in Urine by Culture

395

1.02

0.00

2.7

2.5

—

(3013707) Erythrocyte sedimentation rate by Westergren method

109

1093

0.99

0.00

4.5

3.8

10.8

11.0

mm/h

0.05

103

1010

(3019225) pH of Specimen

108

1.02

0.00

6.1

5.1

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

105

0.95

0.00

1.6

2.4

12.0

8.3

ug/l

—

(3006441) Cardiolipin IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

0.0

4.6

—

52.0

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

0.0

1.0

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

0.0

2.0

—

0.8

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

0.0

1.0

—

(40758292) HTLV I+II Ab panel - Serum

0.00

0.0

2.0

—

(3020650) Glucose [Presence] in Urine

0.00

0.0

1.2

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

0.0

3.2

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(3014271) Vancomycin [Susceptibility]

0.00

0.0

2.0

—

(3002619) Bacteria identified in Specimen by Culture

0.00

0.0

1.2

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.3

—

(3000330) Specific gravity of Urine by Test strip

0.89

0.00

4.5

2.9

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.3

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.96

0.00

1.3

1.5

—

(3044007) Cell count panel - Peritoneal fluid

0.00

0.0

1.3

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.0

—

(3051593) INR in Capillary blood by Coagulation assay

0.00

0.0

3.3

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.6

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.0

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

0.0

1.3

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.5

—

11.0

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.0

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.4

—

26.8

—

(3017704) Immunofixation for Urine

0.00

0.0

2.3

—

(4133840)

0.00

0.0

1.0

—

(3000012) Reticulocyte production index

0.00

0.0

1.9

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.3

—

104.4

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

2.2

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(4027681)

0.00

0.0

1.3

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.1

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3045716) Anion gap in Serum or Plasma

0.00

0.0

2.9

—

8.3

—

(3004451) EKG impression Narrative

0.00

0.0

1.4

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

2.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_MALARIA and mortality.

Females

Parameter	HR [95% CI]	p-value
AB1_MALARIA	2.107 [1.54, 2.88]	< 0.001
Birth year	1.002 [0.99, 1.01]	0.702

During the follow-up period (1.1.1998 — 31.12.2019), 94 out of 611 females with AB1_MALARIA died.

Males

Parameter	HR [95% CI]	p-value
AB1_MALARIA	1.356 [1.05, 1.74]	0.018
Birth year	0.987 [0.98, 1.0]	0.007

During the follow-up period (1.1.1998 — 31.12.2019), 85 out of 823 males with AB1_MALARIA died.

Mortality risk

Mortality risk for people of age

years, who have AB1_MALARIA.

N-year risk	Females	Males
1	0.239%	0.241%
5	1.427%	1.494%
10	3.723%	3.803%
15	7.009%	7.091%
20	12.556%	12.263%

Relationships between endpoints

↥

Index endpoint: AB1_MALARIA – Malaria

GWS hits: 2

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Malaria

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints