Plasmodium falciparum malaria

AB1_MALARIA_FALCIPARIUM

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — B50 Hospital discharge: ICD-9 — 084[0] Hospital discharge: ICD-8 — 084[0] Cause of death: ICD-10 — B50 Cause of death: ICD-9 — 084[0] Cause of death: ICD-8 — 084[0] 2 out of 7 registries used, show all original rules.	90
4. Check minimum number of events None	90
5. Include endpoints None	90
6. Filter based on genotype QC (FinnGen only)	90

Control definitions (FinnGen only)

Control exclude: AB1_PROTOZOAL

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF5

NAME	AB1_MALARIA_FALCIPARIUM
CONTROL_EXCLUDE	AB1_PROTOZOAL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	B50
HD_ICD_9	084[0]
HD_ICD_8	084[0]
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	B50
COD_ICD_9	084[0]
COD_ICD_8	084[0]
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Plasmodium falciparum malaria based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1046	394	612
Only index persons	895	341	554
Unadjusted period prevalence (%)
Whole population	0.02	0.01	0.02
Only index persons	0.02	0.01	0.02
Median age at first event (years)
Whole population	38.27	38.30	38.54
Only index persons	37.53	36.68	38.05

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	90	48	42
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	37.50	34.14	41.35

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
81: Matched controls
808

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

B50.9

ICD-10 Finland

Plasmodium falciparum malaria, unspecified

+∞

62.9

0840A

ICD-9 Finland

Malaria, Falciparum malaria [malignant tertian]

+∞

15.1

B50.0

ICD-10 Finland

Plasmodium falciparum malaria with cerebral complications

+∞

7.4

08400

ICD-8 Finland

Falicparum malaria (malignant tertian)

+∞

6.3

B54

ICD-10 Finland

Unspecified malaria

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3018095) Leukocytes [#/volume] in Urine

250

2.08

2.85

3.1

3.3

13.8

73.0

e6/l

1.64

180

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

183

0.38

2.13

2.0

2.9

752.8

1084.1

ng/l

—

149

(42870588) Differential panel, method unspecified - Blood

229

1.86

2.06

5.7

5.4

—

(3021589) Normoblasts [#/volume] in Blood

315

1.78

1.90

8.7

9.5

0.0

e9/l

0.52

253

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.46

1.90

1.8

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

150

1.92

1.89

2.2

1.8

—

(3003327) Ova and parasites identified in Stool by Light microscopy

3.31

1.69

2.5

1.6

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

3.31

1.69

1.5

1.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

2.02

1.58

1.6

1.7

—

(40758558) Short blood count panel - Blood

187

1.72

1.48

7.9

6.6

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.93

1.47

2.1

1.8

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.32

1.46

1.7

1.6

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.53

1.42

1.0

1.1

—

(3019832) Treponema pallidum Ab [Presence] in Serum

2.00

1.39

1.8

1.7

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

237

1.62

1.32

3.3

2.9

—

(3001604) Monocytes [#/volume] in Blood

361

1.56

1.25

6.8

6.1

0.6

e9/l

0.01

315

(3037467) Urinalysis macro (dipstick) panel - Urine

470

1.58

1.24

3.8

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.87

1.24

2.3

1.7

—

(3006315) Basophils [#/volume] in Blood

362

1.55

1.23

6.9

6.1

0.0

e9/l

0.13

316

(3013115) Eosinophils [#/volume] in Blood

372

1.55

1.22

7.9

6.6

0.2

e9/l

1.74

332

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.21

1.22

1.6

1.5

—

(3002582) Erythrocytes [#/volume] in Urine

223

1.60

1.22

2.9

2.8

16.6

43.0

e6/l

1.23

174

(3044889) 12 lead EKG panel

493

1.57

1.19

2.9

3.5

—

(36660697) Celiac disease serology panel - Serum

2.02

1.18

1.0

1.2

—

(3019198) Lymphocytes [#/volume] in Blood

365

1.53

1.17

6.9

6.2

1.9

e9/l

0.27

325

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.84

1.13

1.8

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.76

1.05

1.4

1.6

—

(3031040) Bacteria [#/volume] in Urine by Automated count

452

1.49

1.01

3.6

3.9

—

6924.9

—

(3009542) Hematocrit [Volume Fraction] of Blood

685

1.70

1.01

14.9

12.7

40.8

40.5

0.26

535

(3003694) ABO and Rh group [Type] in Blood

189

1.53

0.96

1.5

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

1.90

0.88

1.4

1.3

22.2

22.6

iu/l

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

684

1.58

0.82

14.0

11.7

83.9

84.5

ml/min/173m2

0.07

547

(3048689) Calprotectin [Mass/mass] in Stool

1.66

0.80

3.8

2.7

147.4

114.3

ug/g

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.24

0.77

1.4

2.7

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

427

1.38

0.76

10.8

9.8

3.9

4.1

e9/l

0.20

374

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.14

0.76

3.8

2.2

—

(36304419) Bacteria [Presence] in Urine

199

1.43

0.74

3.0

2.8

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

128

1.51

0.73

2.7

2.6

48.3

61.8

ng/l

0.16

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

120

1.51

0.71

1.6

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

683

1.47

0.65

4.8

4.5

1.9

mu/l

0.03

625

(3045414) Leukocytes [Presence] in Urine

1.70

0.62

1.6

1.5

—

(3000494) Fungus identified in Specimen by Culture

1.54

0.62

1.3

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.61

0.0

1.3

—

(3015171) Extractable nuclear Ab [Units/volume] in Serum

0.00

0.61

0.0

1.3

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

518

1.34

0.60

3.2

3.3

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

549

1.34

0.60

4.4

4.0

14.1

14.7

pmol/l

1.09

505

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.60

0.0

1.5

—

56.5

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.66

0.57

2.0

1.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

165

0.69

0.52

7.2

6.0

—

(3000492) Spirometry study

1.55

0.52

1.7

1.3

—

(21494755) Public health laboratory ask at order entry panel

0.58

0.48

1.0

1.3

—

(3017732) Neutrophils [#/volume] in Blood

1.50

0.48

1.3

2.6

3.6

3.5

e9/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.61

0.45

1.8

1.3

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.59

0.43

2.0

1.1

—

(3000330) Specific gravity of Urine by Test strip

1.59

0.43

3.8

2.7

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

562

1.27

0.42

8.4

7.5

73.0

73.8

u/l

0.07

528

(1002224) Polysomnography panel

1.54

0.42

1.0

1.1

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.41

0.0

1.1

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.41

0.0

1.8

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.41

0.0

1.4

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.7

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.41

0.0

1.4

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.41

0.0

1.1

—

(40768443) Skin Pathology biopsy report

1.50

0.41

1.6

1.1

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.45

0.40

1.2

1.1

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.39

0.0

1.1

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

316

1.23

0.38

3.4

6.8

1.2

mmol/l

1.14

272

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.62

0.37

1.4

7.7

—

(3025941) Bacteria identified in Stool by Culture

1.46

0.36

1.2

—

(3026008) Bacteria identified in Urine by Culture

184

1.26

0.35

2.4

—

(40768804) Tissue Pathology biopsy report

281

1.22

0.33

2.5

1.9

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

379

1.20

0.33

7.0

6.6

10.9

10.2

umol/l

0.32

361

(3044640) Blood type and Crossmatch panel - Blood

236

0.80

0.32

3.0

2.2

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

781

1.37

0.29

15.6

14.7

76.8

77.2

umol/l

0.05

781

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

256

1.20

0.28

1.9

1.8

98.3

97.4

pmol/l

0.04

130

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

699

1.23

0.27

3.9

3.6

1.2

1.3

mmol/l

0.36

647

(40761511) CBC panel - Blood by Automated count

786

0.79

0.27

12.2

11.4

—

(3023368) Bacteria identified in Blood by Culture

190

1.21

0.26

4.2

4.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

271

0.84

0.24

2.9

3.7

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.26

0.23

1.0

1.1

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

800

1.28

0.22

11.0

9.6

24.5

27.0

u/l

0.86

775

(3019060) Gas panel - Arterial blood

1.23

0.22

1.2

5.1

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

1.23

0.22

1.4

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(42870365) C reactive protein [Mass/volume] in Blood by High sensitivity method

0.00

0.21

0.0

2.2

—

11.8

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.8

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.4

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.21

0.0

1.5

—

62.0

—

(3024928) Oxygen saturation in Venous blood

0.00

0.21

0.0

1.8

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.21

0.0

1.0

—

(4062490)

0.00

0.21

0.0

1.1

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3007080) Epstein Barr virus nuclear IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.4

—

267.8

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.5

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.8

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.21

0.0

1.6

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

2.9

—

2.7

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.21

0.0

2.2

—

13.5

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.7

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

541

1.15

0.20

2.6

2.7

47.6

44.0

u/l

0.10

504

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.20

0.0

1.2

—

(1761868) Lipid panel - Serum or Plasma

298

0.87

0.20

4.6

2.5

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.21

0.20

2.0

2.5

—

(40761536) Microorganisms panel - Urine sediment

1.14

0.18

3.3

3.5

—

(3012544) pH of Venous blood

1.14

0.18

1.3

3.6

—

(3035350) Ketones [Presence] in Urine by Test strip

346

1.12

0.15

2.7

3.6

0.0

estimate

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

741

1.16

0.14

13.5

13.2

22.5

22.9

mg/l

0.04

580

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

113

1.18

0.14

3.4

2.6

0.4

0.8

e6/l

—

(3021601) Nitrite [Presence] in Urine by Test strip

350

1.10

0.12

4.0

4.9

0.0

estimate

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

164

1.12

0.10

2.4

1.8

3.3

3.0

mg/l

0.11

142

(3022621) pH of Urine by Test strip

1.14

0.10

2.0

2.7

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

165

1.11

0.09

2.7

3.7

—

(3007164) IgA [Mass/volume] in Serum or Plasma

136

1.12

0.09

1.7

1.3

2.0

2.4

g/l

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.82

0.08

1.2

1.3

—

(3002032) Base excess in Venous blood by calculation

0.80

0.08

1.4

3.5

1.8

2.1

mmol/l

—

(3000963) Hemoglobin [Mass/volume] in Blood

832

0.97

0.08

21.2

18.9

134.4

136.9

g/l

0.87

817

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

0.80

0.08

1.3

1.8

—

(3022145) Colonoscopy Study observation

0.82

0.07

1.6

1.3

—

(40768797) Stomach Pathology biopsy report

1.09

0.07

1.8

1.2

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

187

1.09

0.07

4.1

4.8

17.2

20.4

—

(3029937) Albumin [Presence] in Urine by Test strip

193

0.92

0.07

2.7

3.8

0.0

estimate

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

728

1.09

0.06

4.6

4.0

4.6

4.7

mmol/l

0.29

681

(3041096) Erythrocytes [Presence] in Urine by Automated

198

1.08

0.06

2.4

3.1

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

333

0.94

0.06

4.9

4.3

—

(3009261) Glucose [Presence] in Urine by Test strip

357

1.06

0.06

2.8

3.6

0.0

estimate

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

711

0.93

0.05

5.0

4.1

6.2

5.8

mmol/l

0.59

654

(3013707) Erythrocyte sedimentation rate by Westergren method

538

1.06

0.05

3.4

3.8

10.5

10.9

mm/h

0.10

505

(3032080) INR in Blood by Coagulation assay

260

1.05

0.04

7.5

7.0

1.2

inr

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

671

1.05

0.03

6.7

5.0

38.4

39.3

mmol/mol

0.36

633

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

152

1.06

0.02

1.6

1.5

—

(3012516) Albumin [Mass/volume] in Urine

172

1.06

0.02

4.5

3.1

13.0

410.8

mg/l

0.58

115

(3002256) Pathology report gross observation

1.08

0.02

1.5

1.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

104

1.07

0.01

1.4

1.9

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

134

1.05

0.00

1.4

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

724

1.04

0.00

4.5

3.9

1.4

1.5

mmol/l

0.25

672

(3013512) EKG study

186

0.96

0.00

4.5

3.5

—

(3020682) Albumin/Creatinine [Ratio] in Urine

178

1.01

0.00

6.1

3.8

2.4

12.6

mg/mmol

—

117

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

173

0.98

0.00

2.6

2.1

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

264

0.98

0.00

3.4

3.7

103.5

41.6

ng/l

0.32

169

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

5.0

—

0.6

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

2.5

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

1.3

—

91.0

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.2

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.1

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

263.3

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(4027681)

0.00

0.0

1.3

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

6.2

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

3.1

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(3011648) Oxygen content in Venous blood

0.00

0.0

1.7

—

11.6

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

12.9

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.1

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.00

0.00

1.0

2.6

2.4

6.1

ug/l

—

(42870308) Desmosome IgG Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.2

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.6

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

7.6

—

62.9

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

0.0

1.0

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

3.0

—

(4035726)

0.90

0.00

1.2

1.3

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

9.2

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.2

—

253.0

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.3

—

(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum

0.00

0.0

1.4

—

13.4

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.0

1.0

—

(3019225) pH of Specimen

0.94

0.00

4.0

5.3

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.6

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.6

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.02

0.00

1.2

1.7

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.2

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.1

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.0

2.8

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.4

—

(3024731) MCV [Entitic volume]

830

1.00

0.00

20.9

18.8

90.3

90.9

0.50

817

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.0

—

(3043453) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum

0.00

0.0

1.0

—

(3042936) Bacteria identified in Isolate by Culture

100

1.00

0.00

2.5

2.1

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3035941) MCH [Entitic mass]

831

0.98

0.00

20.9

18.8

30.1

30.3

0.45

818

(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum

0.00

0.0

1.2

—

63.9

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

124.2

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

3.4

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.01

0.00

1.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

0.86

0.00

1.3

1.7

—

(3016038) Potassium [Moles/volume] in Urine

0.00

0.0

1.0

—

42.6

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

2.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_MALARIA_FALCIPARIUM and mortality.

Females

Parameter	HR [95% CI]	p-value
AB1_MALARIA_FALCIPARIUM	2.699 [1.72, 4.25]	< 0.001
Birth year	0.99 [0.98, 1.0]	0.021

During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 275 females with AB1_MALARIA_FALCIPARIUM died.

Males

Parameter	HR [95% CI]	p-value
AB1_MALARIA_FALCIPARIUM	1.672 [1.18, 2.38]	0.004
Birth year	0.989 [0.98, 1.0]	0.023

During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 432 males with AB1_MALARIA_FALCIPARIUM died.

Mortality risk

Mortality risk for people of age

years, who have AB1_MALARIA_FALCIPARIUM.

N-year risk	Females	Males
1	0.279%	0.374%
5	1.305%	2.311%
10	3.095%	5.381%
15	5.829%	10.142%
20	10.234%	16.771%

Relationships between endpoints

↥

Index endpoint: AB1_MALARIA_FALCIPARIUM – Plasmodium falciparum malaria

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Plasmodium falciparum malaria

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints