Plasmodium falciparum malaria

AB1_MALARIA_FALCIPARIUM

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — B50 Hospital discharge: ICD-9 — 084[0] Hospital discharge: ICD-8 — 084[0] Cause of death: ICD-10 — B50 Cause of death: ICD-9 — 084[0] Cause of death: ICD-8 — 084[0] 2 out of 7 registries used, show all original rules.	89
4. Check minimum number of events None	89
5. Include endpoints None	89
6. Filter based on genotype QC (FinnGen only)	80

Control definitions (FinnGen only)

Control exclude: AB1_PROTOZOAL

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF5

NAME	AB1_MALARIA_FALCIPARIUM
CONTROL_EXCLUDE	AB1_PROTOZOAL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	B50
HD_ICD_9	084[0]
HD_ICD_8	084[0]
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	B50
COD_ICD_9	084[0]
COD_ICD_8	084[0]
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Plasmodium falciparum malaria based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1046	394	612
Only index persons	895	341	554
Unadjusted period prevalence (%)
Whole population	0.02	0.01	0.02
Only index persons	0.02	0.01	0.02
Median age at first event (years)
Whole population	38.27	38.30	38.54
Only index persons	37.53	36.68	38.05

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	80	46	34
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	38.03	34.74	42.48

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
89: Matched controls
890

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

B50.9

ICD-10 Finland

Plasmodium falciparum malaria, unspecified

+∞

64.7

0840A

ICD-9 Finland

Malaria, Falciparum malaria [malignant tertian]

+∞

17.2

08400

ICD-8 Finland

Falicparum malaria (malignant tertian)

+∞

8.5

B50.0

ICD-10 Finland

Plasmodium falciparum malaria with cerebral complications

+∞

8.5

B54

ICD-10 Finland

Unspecified malaria

+∞

7.4

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3018095) Leukocytes [#/volume] in Urine

245

2.15

3.06

3.1

3.3

13.77

73.81

e6/l

1.63

177

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

180

0.39

1.98

2.0

2.9

752.76

1096.35

ng/l

—

147

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.51

1.97

1.8

—

(3021589) Normoblasts [#/volume] in Blood

313

1.80

1.97

8.7

9.5

0.00

0.01

e9/l

0.52

251

(46235355) HIV 1 and 2 tests - Meaningful Use set

149

1.94

2.2

1.8

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

3.49

1.78

1.5

1.3

—

(3003327) Ova and parasites identified in Stool by Light microscopy

3.31

1.69

2.5

1.6

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

2.02

1.58

1.6

1.7

—

(40758558) Short blood count panel - Blood

186

1.74

1.52

7.9

6.6

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.93

1.48

2.1

1.8

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.32

1.46

1.7

1.6

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

232

1.67

1.45

3.3

2.9

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.53

1.42

1.0

1.1

—

(3019832) Treponema pallidum Ab [Presence] in Serum

2.00

1.39

1.8

1.7

—

(3002582) Erythrocytes [#/volume] in Urine

219

1.64

1.32

2.9

2.7

16.60

43.61

e6/l

1.24

171

(3013115) Eosinophils [#/volume] in Blood

369

1.58

1.29

7.9

6.6

0.15

0.20

e9/l

1.75

329

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.90

1.28

2.3

1.7

—

(3001604) Monocytes [#/volume] in Blood

360

1.57

1.28

6.9

6.2

0.57

0.58

e9/l

0.05

315

(3006315) Basophils [#/volume] in Blood

360

1.57

1.28

6.9

6.2

0.04

e9/l

0.14

314

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.21

1.22

1.6

1.5

—

(3019198) Lymphocytes [#/volume] in Blood

364

1.55

1.20

6.9

6.2

1.93

1.87

e9/l

0.23

326

(36660697) Celiac disease serology panel - Serum

2.02

1.18

1.0

1.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

464

1.56

1.18

3.9

3.7

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.86

1.17

1.8

—

(3044889) 12 lead EKG panel

487

1.55

1.12

2.9

3.5

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.80

1.12

1.4

1.6

—

(3003694) ABO and Rh group [Type] in Blood

186

1.56

1.03

1.5

—

(3031040) Bacteria [#/volume] in Urine by Automated count

447

1.46

0.93

3.6

3.8

—

6924.88

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

1.90

0.88

1.4

1.3

22.21

22.65

iu/l

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

683

1.62

0.86

14.0

11.6

83.95

84.74

ml/min/173m2

0.10

546

(3048689) Calprotectin [Mass/mass] in Stool

1.69

0.83

3.8

2.7

147.38

114.28

ug/g

—

(36304419) Bacteria [Presence] in Urine

196

1.46

0.80

3.0

2.7

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

425

1.40

0.80

10.8

9.9

3.93

4.10

e9/l

0.21

372

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

126

1.54

0.78

2.7

2.5

48.31

61.45

ng/l

0.16

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.24

0.77

1.4

2.7

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.24

0.77

3.8

2.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

330

1.39

0.75

7.2

6.8

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

119

1.53

0.74

1.6

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

512

1.38

0.70

3.2

3.3

—

(3000494) Fungus identified in Specimen by Culture

1.58

0.68

1.3

—

(3045414) Leukocytes [Presence] in Urine

1.77

0.65

1.6

—

(3026008) Bacteria identified in Urine by Culture

186

1.40

0.63

2.3

2.4

—

(3000330) Specific gravity of Urine by Test strip

1.71

0.62

3.8

2.7

—

(3015171) Extractable nuclear Ab [Units/volume] in Serum

0.00

0.61

0.0

1.3

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.60

0.0

1.5

—

56.50

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

677

1.44

0.59

4.9

4.5

1.86

mu/l

0.00

621

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.67

0.57

2.0

1.2

—

(3022217) INR in Platelet poor plasma by Coagulation assay

294

1.31

0.55

15.1

11.0

1.54

1.20

inr

0.92

(3000492) Spirometry study

1.55

0.52

1.7

1.4

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

556

1.31

0.51

8.4

7.6

73.00

73.95

u/l

0.08

522

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

546

1.30

0.50

4.4

4.0

14.13

14.70

pmol/l

1.00

502

(21494755) Public health laboratory ask at order entry panel

0.58

0.48

1.0

1.3

—

(3017732) Neutrophils [#/volume] in Blood

1.50

0.48

1.3

2.6

3.60

9.69

e9/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.61

0.45

1.8

1.3

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.65

0.44

2.0

1.1

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

312

1.26

0.43

3.4

6.8

1.23

1.21

mmol/l

1.08

273

(1002224) Polysomnography panel

1.60

0.43

1.0

1.1

—

(40768443) Skin Pathology biopsy report

1.54

0.42

1.6

1.2

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.41

0.0

1.9

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.41

0.0

1.1

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.41

0.0

1.4

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.41

0.0

1.4

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.41

0.0

1.1

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.7

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.45

0.40

1.2

1.1

—

(40768804) Tissue Pathology biopsy report

276

1.25

0.40

2.5

1.9

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.39

0.0

1.1

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.39

0.0

1.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.62

0.37

1.4

7.7

—

(3025941) Bacteria identified in Stool by Culture

1.46

0.36

1.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

253

1.22

0.32

1.9

1.8

98.33

98.07

pmol/l

0.01

128

(3020564) Creatinine [Moles/volume] in Serum or Plasma

772

1.36

0.29

15.7

14.7

76.39

77.14

umol/l

0.10

772

(3044640) Blood type and Crossmatch panel - Blood

234

0.81

0.29

3.0

2.2

—

(3023368) Bacteria identified in Blood by Culture

188

1.23

0.29

3.9

4.5

—

(40761511) CBC panel - Blood by Automated count

777

0.78

0.29

12.2

11.4

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

377

1.16

0.24

7.2

6.6

10.94

10.16

umol/l

0.34

360

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

538

1.17

0.23

2.6

2.7

47.62

44.10

u/l

0.09

501

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.26

0.23

1.0

1.1

—

(3019060) Gas panel - Arterial blood

1.26

0.23

1.2

5.2

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

693

1.20

0.22

3.9

3.6

1.21

1.29

mmol/l

0.52

642

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

1.23

0.22

1.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

269

0.85

0.22

2.9

3.7

—

(3007080) Epstein Barr virus nuclear IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.4

—

267.80

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.8

—

(42870365) C reactive protein [Mass/volume] in Blood by High sensitivity method

0.00

0.21

0.0

2.2

—

11.80

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.9

—

79.30

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(4062490) Immunoglobulin typing, IgG

0.00

0.21

0.0

1.1

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.4

—

(3024928) Oxygen saturation in Venous blood

0.00

0.21

0.0

1.8

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.21

0.0

1.0

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.8

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.21

0.0

1.6

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

2.9

—

2.67

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.5

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.21

0.0

2.2

—

13.52

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.7

—

(3035350) Ketones [Presence] in Urine by Test strip

341

1.15

0.20

2.7

3.7

0.00

estimate

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.24

0.20

2.0

2.6

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.20

0.0

1.2

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

109

1.23

0.20

3.4

2.5

0.39

0.82

e6/l

—

(1761868) Lipid panel - Serum or Plasma

297

0.87

0.19

4.6

2.5

—

(3012544) pH of Venous blood

1.18

0.18

1.3

3.6

—

(40761536) Microorganisms panel - Urine sediment

1.14

0.18

3.3

3.5

—

(3021601) Nitrite [Presence] in Urine by Test strip

345

1.12

0.16

4.0

4.9

0.00

estimate

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

0.81

0.15

6.6

6.5

103.86

103.76

mmol/l

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

791

1.27

0.14

11.0

9.7

24.50

27.08

u/l

0.89

766

(3011397) Hemoglobin [Presence] in Urine by Test strip

162

1.14

0.13

2.7

3.7

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

733

1.15

0.12

13.7

13.2

22.35

22.84

mg/l

0.04

573

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

163

1.13

0.12

2.4

1.8

3.29

2.98

mg/l

0.11

141

(3022621) pH of Urine by Test strip

1.17

0.10

2.0

2.7

—

(3009261) Glucose [Presence] in Urine by Test strip

352

1.09

0.10

2.8

3.6

0.00

estimate

—

(3013707) Erythrocyte sedimentation rate by Westergren method

532

1.09

0.10

3.4

3.8

10.50

10.85

mm/h

0.09

499

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.04

0.09

1.2

1.7

—

(3007164) IgA [Mass/volume] in Serum or Plasma

136

1.12

0.09

1.7

1.3

1.98

2.36

g/l

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.82

0.08

1.2

1.3

—

(3002032) Base excess in Venous blood by calculation

0.82

0.08

1.4

3.5

1.16

2.15

mmol/l

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

704

0.91

0.08

5.0

4.1

6.16

5.84

mmol/l

0.57

648

(3000963) Hemoglobin [Mass/volume] in Blood

823

0.95

0.08

21.3

19.0

134.52

136.85

g/l

0.80

808

(3041096) Erythrocytes [Presence] in Urine by Automated

196

1.09

0.08

2.4

3.1

—

(3035941) MCH [Entitic mass]

822

0.97

0.08

21.1

18.8

30.11

30.33

0.44

809

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

0.81

0.08

1.3

1.8

—

(3022145) Colonoscopy Study observation

0.84

0.07

1.6

1.3

—

(40768797) Stomach Pathology biopsy report

1.09

0.07

1.8

1.2

—

(3029937) Albumin [Presence] in Urine by Test strip

193

0.92

0.07

2.7

3.8

0.00

0.02

estimate

—

(3002256) Pathology report gross observation

1.11

0.04

1.5

1.3

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

180

1.07

0.04

4.3

4.8

17.22

20.56

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

151

1.07

0.03

1.6

1.5

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

721

1.07

0.03

4.6

4.1

4.64

4.73

mmol/l

0.36

676

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

329

0.96

0.03

2.9

2.5

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

103

1.08

0.02

1.4

1.9

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

134

1.05

0.00

1.4

—

(3020682) Albumin/Creatinine [Ratio] in Urine

176

0.96

0.00

5.8

3.7

2.39

12.68

mg/mmol

—

116

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

664

1.04

0.00

6.7

4.9

38.37

39.31

mmol/mol

0.38

627

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

172

0.99

0.00

2.6

2.1

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

262

0.99

0.00

3.4

3.7

103.47

41.93

ng/l

0.32

167

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

717

1.02

0.00

4.5

3.9

1.43

1.46

mmol/l

0.19

667

(3013512) EKG study

184

0.97

0.00

4.5

3.6

—

(3042936) Bacteria identified in Isolate by Culture

1.01

0.00

2.5

2.1

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

3.10

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

3.4

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

6.2

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.2

—

(3024731) MCV [Entitic volume]

821

0.98

0.00

21.1

18.9

90.27

90.90

0.48

808

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

263.33

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

2.3

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.6

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(3011648) Oxygen content in Venous blood

0.00

0.0

1.7

—

11.62

—

(3007798) IgG/Albumin [Mass Ratio] in Cerebral spinal fluid

0.00

0.0

1.7

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

12.85

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.3

—

(3024666) Lithium [Moles/volume] in Serum or Plasma

0.00

0.0

5.0

—

0.60

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.0

—

(40768795) Lymph node Pathology biopsy report

0.00

-0.00

0.0

1.1

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.01

-0.00

1.6

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.1

—

(42870308) Desmosome IgG Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.2

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.9

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum

0.00

-0.00

0.0

1.2

—

63.94

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

-0.00

0.0

1.2

—

253.00

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

0.87

-0.00

1.3

1.7

—

(3015183) Erythrocyte sedimentation rate

0.00

-0.00

0.0

1.2

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

-0.00

0.0

8.4

—

(3043453) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.00

-0.00

1.0

2.6

2.40

6.11

ug/l

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(4035726) Immunohistochemistry procedure

0.90

-0.00

1.2

1.3

—

(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum

0.00

-0.00

0.0

1.4

—

13.42

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

-0.00

0.0

1.6

—

65.42

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3012441) Differential panel - Pleural fluid

0.00

-0.00

0.0

1.6

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

-0.00

0.0

1.4

—

90.08

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

2.8

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

7.6

—

62.94

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

-0.00

0.0

1.0

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.4

—

(3019225) pH of Specimen

0.94

-0.00

4.0

5.3

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

124.18

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

-0.00

0.0

1.0

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

-0.00

0.0

1.1

—

(40768806) Pleura Pathology biopsy report

0.00

-0.00

0.0

3.0

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

2.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_MALARIA_FALCIPARIUM and mortality.

Females

Parameter	HR [95% CI]	p-value
AB1_MALARIA_FALCIPARIUM	2.699 [1.72, 4.25]	< 0.001
Birth year	0.99 [0.98, 1.0]	0.021

During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 275 females with AB1_MALARIA_FALCIPARIUM died.

Males

Parameter	HR [95% CI]	p-value
AB1_MALARIA_FALCIPARIUM	1.672 [1.18, 2.38]	0.004
Birth year	0.989 [0.98, 1.0]	0.023

During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 432 males with AB1_MALARIA_FALCIPARIUM died.

Mortality risk

Mortality risk for people of age

years, who have AB1_MALARIA_FALCIPARIUM.

N-year risk	Females	Males
1	0.279%	0.374%
5	1.305%	2.311%
10	3.095%	5.381%
15	5.829%	10.142%
20	10.234%	16.771%

Relationships between endpoints

↥

Index endpoint: AB1_MALARIA_FALCIPARIUM – Plasmodium falciparum malaria

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Plasmodium falciparum malaria

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints