Benign neoplasm: Lymph nodes

CD2_BENIGN_LYMPHNODES

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D36.0& Hospital discharge: ICD-9 — 2298A Cause of death: ICD-10 — D36.0& Cause of death: ICD-9 — 2298A 2 out of 7 registries used, show all original rules.	96
4. Check minimum number of events None	96
5. Include endpoints None	96
6. Filter based on genotype QC (FinnGen only)	96

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D36
Name in latin: Neoplasma benignum lymphonodorum

NAME	CD2_BENIGN_LYMPHNODES
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D360
HD_ICD_9	2298A
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D360
COD_ICD_9	2298A
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Benign neoplasm: Lymph nodes based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Benign neoplasm: Lymph nodes

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	852	474	370
Only index persons	714	415	299
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.02	0.01
Median age at first event (years)
Whole population	49.64	50.35	48.54
Only index persons	47.74	49.63	45.12

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	96	65	31
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	47.07	45.60	50.15

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
87: Matched controls
871

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D36.0

ICD-10 Finland

Benign neoplasm: Lymph nodes

+∞

117.2

PJD41

NOMESCO Finland

Excision of cervical lymph nodes

44.6

12.7

F33.2

ICD-10 Finland

Recurrent depressive disorder, current episode severe without psychotic symptoms

12.4

7.0

R59.0

ICD-10 Finland

Localized enlarged lymph nodes

13.9

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3001604) Monocytes [#/volume] in Blood

399

2.24

3.57

7.2

5.6

0.6

e9/l

0.00

354

(3006315) Basophils [#/volume] in Blood

399

2.24

3.57

7.4

5.6

0.0

e9/l

0.84

356

(3013115) Eosinophils [#/volume] in Blood

410

2.24

3.52

7.5

6.2

0.2

e9/l

0.55

369

(3019198) Lymphocytes [#/volume] in Blood

410

2.14

3.20

7.2

5.5

1.9

1.8

e9/l

0.63

368

(40768795) Lymph node Pathology biopsy report

8.70

2.78

1.0

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.73

2.78

2.1

1.4

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

6.31

2.74

1.2

1.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

319

1.93

2.53

4.6

4.1

—

(40760892) CBC W Ordered Manual Differential panel - Blood

191

2.01

2.49

4.5

4.8

—

(3019150) Specific gravity of Urine by Refractometry

176

2.02

2.44

5.2

4.5

1.0

kg/l

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

4.84

2.31

1.2

3.4

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

4.11

2.30

1.3

1.5

—

(4010399)

2.58

2.23

2.1

1.4

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

3.89

2.19

1.4

1.2

—

(3021601) Nitrite [Presence] in Urine by Test strip

398

1.82

2.14

6.9

5.5

0.0

estimate

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

296

1.82

2.13

3.3

3.8

28.6

41.6

ng/l

0.49

187

(3035350) Ketones [Presence] in Urine by Test strip

402

1.78

2.03

4.8

4.0

0.0

estimate

—

(40760888) Immunoglobulin light chains.free panel - Serum

4.73

1.96

2.0

5.4

—

(3005322) IgE [Units/volume] in Serum or Plasma

2.57

1.93

1.5

1.3

479.9

178.1

u/ml

0.33

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

134

1.94

1.88

2.2

1.6

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

112

1.99

1.82

2.1

1.8

—

(3018010) Neutrophils/100 leukocytes in Blood

373

1.71

1.80

7.7

5.2

55.5

57.4

0.49

354

(3026008) Bacteria identified in Urine by Culture

254

1.74

1.79

3.3

3.0

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

2.08

1.79

3.8

4.3

1.0

mmol/l

0.01

(3023368) Bacteria identified in Blood by Culture

195

1.78

1.74

6.5

4.1

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

2.09

1.72

4.7

3.7

227.5

252.5

u/l

0.40

(3052851) Hemolysis interference index of Serum or Plasma

3.30

1.69

1.3

3.5

—

(3009261) Glucose [Presence] in Urine by Test strip

407

1.67

1.68

4.9

4.0

0.0

estimate

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.09

1.65

2.2

1.9

—

(3037756) Immunofixation for Serum or Plasma

3.71

1.63

2.2

1.4

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.82

1.61

2.0

1.7

—

(3041096) Erythrocytes [Presence] in Urine by Automated

243

1.69

1.60

3.3

3.4

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

103

1.92

1.54

2.3

1.5

—

(42870588) Differential panel, method unspecified - Blood

264

1.65

1.52

7.6

5.0

—

(3012544) pH of Venous blood

2.12

1.52

2.1

3.2

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.18

1.51

2.5

1.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.01

1.50

2.3

1.7

—

(1761482) Bacteria [#/volume] in Urine by Culture

2.84

1.46

3.0

5.2

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

3.04

1.37

1.6

2.1

—

(3037467) Urinalysis macro (dipstick) panel - Urine

554

1.61

1.33

6.2

4.3

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.40

1.30

2.0

1.4

—

(3044290) Cell count panel - Cerebral spinal fluid

2.87

1.30

1.0

1.2

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

474

1.56

1.30

10.9

9.5

4.0

4.1

e9/l

0.18

419

(3015736) pH of Urine

314

1.53

1.21

5.0

3.8

—

(3037522) Nuclear Ab [Titer] in Serum

114

1.71

1.12

2.1

1.5

250.0

702.9

titre

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

148

1.63

1.11

1.6

1.3

11.6

u/ml

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.28

1.10

1.9

2.2

—

(3003327) Ova and parasites identified in Stool by Light microscopy

2.21

1.08

1.1

1.4

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

158

1.60

1.07

1.6

1.3

10.8

28.4

iu/ml

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

167

1.58

1.06

2.4

2.0

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.82

1.05

5.0

4.0

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

178

1.55

1.00

5.8

4.1

—

(3000330) Specific gravity of Urine by Test strip

1.96

0.96

4.9

3.9

—

(4035726)

1.79

0.94

1.7

1.3

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.94

0.90

1.1

1.2

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

192

1.49

0.88

1.4

1.2

0.9

1.4

u/ml

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.85

0.87

1.3

1.2

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

141

1.53

0.83

3.7

2.9

116.8

106.2

ng/l

0.05

(3022621) pH of Urine by Test strip

1.73

0.81

3.6

2.9

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

151

1.50

0.80

1.3

1.5

—

(40768804) Tissue Pathology biopsy report

317

1.39

0.78

2.4

2.0

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

152

1.49

0.78

1.6

1.8

709.8

496.2

pmol/l

0.61

128

(3029937) Albumin [Presence] in Urine by Test strip

224

1.42

0.78

4.9

4.2

0.0

estimate

—

(3013707) Erythrocyte sedimentation rate by Westergren method

608

1.41

0.75

6.2

3.9

14.0

10.6

mm/h

0.73

561

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

2.05

0.74

1.4

2.8

232.2

191.9

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.05

0.74

1.0

2.2

—

(3044889) 12 lead EKG panel

548

1.37

0.72

3.5

—

(40761535) Cells panel - Urine sediment

1.61

0.72

3.6

4.1

—

(3020891) Body temperature

1.97

0.71

3.2

4.5

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.72

0.70

2.7

4.5

25.8

24.8

mmol/l

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.57

0.67

2.0

1.9

—

(3002256) Pathology report gross observation

1.57

0.67

1.4

1.2

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

372

1.34

0.67

9.8

5.6

1.2

mmol/l

0.33

309

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.83

0.67

1.4

1.1

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.83

0.67

1.4

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.83

0.67

1.4

1.1

—

(3018418) pH of Serum or Plasma

239

1.37

0.67

8.3

3.7

7.4

—

(3019060) Gas panel - Arterial blood

1.64

0.66

4.3

5.1

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.64

0.66

1.6

—

(3009542) Hematocrit [Volume Fraction] of Blood

729

0.73

0.64

24.2

13.7

38.7

40.2

0.71

550

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

1.69

0.64

1.9

1.6

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.70

0.62

2.2

2.6

—

(3028026) IgM [Mass/volume] in Serum or Plasma

1.55

0.60

2.0

1.5

1.2

1.3

g/l

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

107

1.48

0.60

2.2

2.1

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.59

0.0

1.1

—

(3025941) Bacteria identified in Stool by Culture

1.58

0.57

1.1

1.2

—

(3008898) HLA-B27 [Presence]

1.57

0.54

1.0

1.1

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.48

0.54

2.3

2.0

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.59

0.48

1.4

1.8

—

(3018095) Leukocytes [#/volume] in Urine

308

1.27

0.48

4.1

3.5

30.5

68.8

e6/l

0.97

216

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

289

1.27

0.47

3.5

2.9

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.43

0.46

2.4

2.8

0.2

0.1

e6/l

—

(40761511) CBC panel - Blood by Automated count

837

0.73

0.44

23.3

12.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

379

1.24

0.44

7.8

3.8

—

(3028300) Cannabinoids [Presence] in Urine

1.65

0.43

1.0

1.5

—

(3027008) Opiates [Presence] in Urine

1.65

0.43

1.0

1.5

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.44

0.43

2.0

2.5

0.2

g/l

0.17

(3027944) Amphetamines [Presence] in Urine

1.59

0.43

1.0

1.5

—

(3000764) Benzodiazepines [Presence] in Urine

1.59

0.43

1.0

1.5

—

(40758558) Short blood count panel - Blood

213

0.75

0.42

10.5

6.8

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.41

0.0

3.5

—

21.8

—

(3000991) Gas panel - Venous blood

1.36

0.41

2.4

4.3

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.50

0.41

2.0

1.6

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.50

0.41

1.6

1.5

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

344

1.23

0.38

6.1

4.3

35.1

35.7

g/l

0.28

329

(1761868) Lipid panel - Serum or Plasma

303

0.81

0.37

3.2

2.8

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.36

0.36

3.3

1.9

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

184

1.25

0.34

2.0

1.8

—

(3013512) EKG study

227

0.80

0.33

4.9

3.5

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.40

0.32

1.3

1.7

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

111

1.31

0.32

2.1

2.4

g/l

0.07

100

(3012095) Magnesium [Moles/volume] in Serum or Plasma

131

1.27

0.29

4.0

2.8

0.8

mmol/l

1.02

122

(40768797) Stomach Pathology biopsy report

118

0.74

0.29

1.1

1.2

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.27

0.28

2.8

1.8

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.23

0.27

5.4

3.8

1.2

mmol/l

—

(40761536) Microorganisms panel - Urine sediment

1.24

0.26

3.6

3.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.27

0.24

1.4

1.6

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.33

0.23

1.2

1.1

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.21

0.0

1.5

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.5

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.5

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.21

0.0

1.3

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.5

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.5

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.21

0.0

3.4

—

311.2

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

10.2

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.21

0.0

1.1

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.29

0.21

2.3

2.1

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

2.1

—

(3032080) INR in Blood by Coagulation assay

301

1.15

0.21

13.2

8.9

1.3

1.2

inr

—

100

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.20

0.0

1.0

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

550

0.88

0.20

4.3

3.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

312

1.14

0.19

2.2

1.9

91.2

98.1

pmol/l

0.44

147

(3044640) Blood type and Crossmatch panel - Blood

254

1.14

0.19

3.1

1.9

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

148

1.18

0.18

1.5

2.4

2.5

mmol/l

0.58

128

(3019225) pH of Specimen

1.14

0.18

2.9

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

149

1.17

0.17

1.8

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.79

0.15

9.0

7.7

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

838

0.85

0.14

26.1

15.5

71.7

73.5

umol/l

0.47

838

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

113

1.17

0.14

1.2

1.7

1.9

1.5

0.43

(3015377) Calcium [Moles/volume] in Serum or Plasma

279

1.11

0.13

2.1

3.2

2.4

mmol/l

0.66

250

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

747

0.91

0.10

22.3

12.4

84.1

83.0

ml/min/173m2

0.18

601

(3012516) Albumin [Mass/volume] in Urine

184

1.11

0.10

3.3

3.2

3030.5

58.1

mg/l

0.48

120

(3021589) Normoblasts [#/volume] in Blood

372

1.08

0.10

18.0

8.8

0.0

e9/l

0.50

305

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

1.04

0.08

2.0

3.3

18.3

59.1

u/ml

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.82

0.08

1.4

1.5

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.10

0.08

1.9

2.4

5.7

4.9

ug/l

—

(36660697) Celiac disease serology panel - Serum

1.05

0.08

1.1

—

(3000492) Spirometry study

1.07

0.07

1.0

1.4

—

(21494755) Public health laboratory ask at order entry panel

1.03

0.07

1.4

1.3

—

(3042936) Bacteria identified in Isolate by Culture

119

1.11

0.06

2.9

1.9

—

(3003694) ABO and Rh group [Type] in Blood

222

0.93

0.06

2.1

1.5

—

(3020682) Albumin/Creatinine [Ratio] in Urine

201

0.93

0.05

4.4

4.0

8.3

9.8

mg/mmol

0.08

130

(3009508) Creatinine [Moles/volume] in Urine

209

1.07

0.05

2.8

2.9

7.1

8.0

mmol/l

0.38

170

(36304419) Bacteria [Presence] in Urine

229

1.06

0.05

3.3

2.6

—

(3000494) Fungus identified in Specimen by Culture

1.07

0.01

3.5

1.3

—

(3022145) Colonoscopy Study observation

105

0.95

0.00

2.0

1.5

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

811

0.99

0.00

24.3

13.4

22.4

22.6

mg/l

0.02

628

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

3.6

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

0.8

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

6.2

—

1104.2

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

20.4

—

2114.6

—

(3044007) Cell count panel - Peritoneal fluid

0.00

0.0

1.4

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

1.8

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.4

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.8

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.7

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.2

—

6.1

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.7

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.4

—

1.7

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

1.5

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.1

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.7

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.3

—

200.8

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

1.02

0.00

3.5

2.8

124.8

76.8

ng/l

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

1.9

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.3

—

(4146454)

0.00

0.0

3.6

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.7

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.2

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

1.3

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.88

0.00

1.4

1.5

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.0

1.2

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_LYMPHNODES and mortality.

Females

Parameter	HR [95% CI]	p-value
CD2_BENIGN_LYMPHNODES	1.777 [1.35, 2.34]	< 0.001
Birth year	1.0 [0.99, 1.01]	0.901

During the follow-up period (1.1.1998 — 31.12.2019), 98 out of 393 females with CD2_BENIGN_LYMPHNODES died.

Males

Parameter	HR [95% CI]	p-value
CD2_BENIGN_LYMPHNODES	2.227 [1.65, 3.0]	< 0.001
Birth year	0.99 [0.98, 1.0]	0.086

During the follow-up period (1.1.1998 — 31.12.2019), 101 out of 327 males with CD2_BENIGN_LYMPHNODES died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_LYMPHNODES.

N-year risk	Females	Males
1	0.232%	0.424%
5	1.325%	2.999%
10	3.068%	7.057%
15	5.479%	13.282%
20	9.918%	22.164%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_LYMPHNODES – Benign neoplasm: Lymph nodes

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Benign neoplasm: Lymph nodes

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints