Benign neoplasm: Lymph nodes

CD2_BENIGN_LYMPHNODES

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D36.0& Hospital discharge: ICD-9 — 2298A Cause of death: ICD-10 — D36.0& Cause of death: ICD-9 — 2298A 2 out of 7 registries used, show all original rules.	97
4. Check minimum number of events None	97
5. Include endpoints None	97
6. Filter based on genotype QC (FinnGen only)	95

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D36
Name in latin: Neoplasma benignum lymphonodorum

NAME	CD2_BENIGN_LYMPHNODES
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D360
HD_ICD_9	2298A
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D360
COD_ICD_9	2298A
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Benign neoplasm: Lymph nodes based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	852	474	370
Only index persons	714	415	299
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.02	0.01
Median age at first event (years)
Whole population	49.64	50.35	48.54
Only index persons	47.74	49.63	45.12

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	95	65	30
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	46.98	45.81	49.50

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
97: Matched controls
970

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D36.0

ICD-10 Finland

Benign neoplasm: Lymph nodes

+∞

131.6

PJD41

NOMESCO Finland

Excision of cervical lymph nodes

58.3

16.7

R22.1

ICD-10 Finland

Localized swelling, mass and lump, neck

13.4

7.8

R59.0

ICD-10 Finland

Localized enlarged lymph nodes

10.5

7.0

PJA10

NOMESCO Finland

Exploration of lymph nodes

43.2

6.9

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40760892) CBC W Ordered Manual Differential panel - Blood

371

2.30

3.88

7.6

6.0

—

(3006315) Basophils [#/volume] in Blood

403

2.28

3.74

7.3

5.5

0.05

0.04

e9/l

0.84

359

(3001604) Monocytes [#/volume] in Blood

404

2.27

3.70

7.2

5.5

0.58

0.57

e9/l

0.03

360

(3013115) Eosinophils [#/volume] in Blood

414

2.28

3.68

7.4

6.2

0.21

0.19

e9/l

0.57

372

(40768795) Lymph node Pathology biopsy report

10.54

3.54

1.0

—

(3019198) Lymphocytes [#/volume] in Blood

415

2.17

3.33

7.2

5.5

1.91

1.80

e9/l

0.64

376

(3038177) Helicobacter pylori Ab [Presence] in Serum

6.31

2.74

1.2

1.4

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.68

2.69

2.1

1.4

—

(21494815) CD4 cells/100 lymphocytes in Specimen

6.51

2.40

2.4

1.0

36.20

40.80

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

325

1.87

2.34

4.6

4.0

—

(3019150) Specific gravity of Urine by Refractometry

179

1.98

2.32

5.2

4.5

1.01

kg/l

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

4.10

2.30

1.3

1.5

—

(3021601) Nitrite [Presence] in Urine by Test strip

404

1.83

2.22

6.7

5.5

0.00

estimate

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

3.88

2.19

1.4

1.2

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

4.49

2.18

1.2

3.2

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

303

1.83

2.18

3.4

3.8

28.19

40.12

ng/l

0.47

196

(4200892) Spirometry reversibility

2.53

2.15

2.1

1.4

—

(3035350) Ketones [Presence] in Urine by Test strip

408

1.80

2.12

4.7

4.0

0.00

estimate

—

(3023368) Bacteria identified in Blood by Culture

196

1.85

1.99

6.4

4.1

—

(40760888) Immunoglobulin light chains.free panel - Serum

4.73

1.96

2.0

5.4

—

(3018010) Neutrophils/100 leukocytes in Blood

376

1.75

1.95

7.7

5.2

55.57

57.37

0.47

356

(3005322) IgE [Units/volume] in Serum or Plasma

2.57

1.93

1.5

1.3

479.86

178.10

u/ml

0.33

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

135

1.92

1.83

2.2

1.6

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

2.08

1.79

3.8

4.3

1.02

mmol/l

0.01

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

113

1.97

1.77

2.2

1.8

—

(3009261) Glucose [Presence] in Urine by Test strip

413

1.69

1.75

4.8

4.0

0.00

estimate

—

(3041096) Erythrocytes [Presence] in Urine by Automated

247

1.73

1.74

3.2

3.4

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

2.06

1.67

4.7

3.7

227.50

252.44

u/l

0.40

(3037756) Immunofixation for Serum or Plasma

3.70

1.63

2.2

1.4

—

(3026008) Bacteria identified in Urine by Culture

260

1.68

1.62

3.3

3.0

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.82

1.61

2.0

1.7

—

(3052851) Hemolysis interference index of Serum or Plasma

3.13

1.61

1.3

3.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.06

1.60

2.2

1.8

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

104

1.90

1.50

2.3

1.5

—

(3012544) pH of Venous blood

2.09

1.46

2.1

3.2

—

(1761482) Bacteria [#/volume] in Urine by Culture

2.84

1.46

3.0

5.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.98

1.45

2.3

1.7

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.14

1.45

2.5

1.4

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

479

1.59

1.39

10.8

9.4

3.96

4.09

e9/l

0.19

423

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.98

1.38

4.9

4.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

561

1.63

1.38

6.1

4.2

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

3.04

1.37

1.6

2.1

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.40

1.30

2.0

1.4

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.87

1.30

2.4

2.8

—

(3044290) Cell count panel - Cerebral spinal fluid

2.87

1.30

1.0

1.2

—

(4035726) Immunohistochemistry procedure

1.96

1.26

1.6

1.3

—

(3027315) Oxygen [Partial pressure] in Blood

2.72

1.23

3.8

2.8

8.36

8.79

kpa

—

(3013290) Carbon dioxide [Partial pressure] in Blood

2.72

1.23

3.8

2.8

5.14

4.91

kpa

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.28

1.10

1.9

2.2

—

(3037522) Nuclear Ab [Titer] in Serum

115

1.69

1.09

2.1

1.5

250.00

702.86

titre

—

(3003327) Ova and parasites identified in Stool by Light microscopy

2.21

1.08

1.1

1.4

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

149

1.62

1.08

1.6

1.3

1.27

11.63

u/ml

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

193

1.55

1.06

1.4

1.2

0.85

1.36

u/ml

0.45

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

159

1.59

1.04

1.6

1.3

10.82

27.91

iu/ml

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

168

1.57

1.03

2.4

2.0

—

(3000330) Specific gravity of Urine by Test strip

1.96

0.96

4.9

3.9

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

180

1.52

0.95

5.8

4.1

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

155

1.54

0.92

1.6

1.8

700.88

499.98

pmol/l

0.61

131

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.98

0.91

2.5

4.5

25.51

24.80

mmol/l

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.94

0.90

1.1

1.2

—

(40768804) Tissue Pathology biopsy report

321

1.42

0.88

2.4

2.0

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.85

0.87

1.3

1.2

—

(3029937) Albumin [Presence] in Urine by Test strip

229

1.45

0.86

4.8

4.2

0.00

estimate

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

141

1.53

0.83

3.7

2.9

116.79

106.16

ng/l

0.05

(3013707) Erythrocyte sedimentation rate by Westergren method

613

1.44

0.83

6.1

3.9

13.83

10.62

mm/h

0.68

566

(3022621) pH of Urine by Test strip

1.73

0.81

3.6

2.9

—

(3018418) pH of Serum or Plasma

242

1.41

0.78

8.0

3.7

7.41

7.40

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

152

1.49

0.77

1.3

1.5

—

(3044889) 12 lead EKG panel

556

1.38

0.75

3.7

3.5

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

2.05

0.74

1.4

2.8

232.20

191.92

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.05

0.74

1.0

2.1

—

(3020891) Body temperature

1.90

0.69

3.2

4.4

—

(3002256) Pathology report gross observation

1.57

0.67

1.4

1.2

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.57

0.67

2.0

1.9

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.83

0.67

1.4

1.1

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.83

0.67

1.4

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.83

0.67

1.4

1.1

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.64

0.66

1.6

—

(3019060) Gas panel - Arterial blood

1.64

0.66

4.3

5.1

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

1.69

0.64

1.9

1.6

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

375

1.32

0.62

9.8

5.6

1.22

1.21

mmol/l

0.29

313

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.70

0.62

2.2

2.6

—

(3018095) Leukocytes [#/volume] in Urine

309

1.32

0.60

4.1

3.5

29.83

62.38

e6/l

0.82

217

(3028026) IgM [Mass/volume] in Serum or Plasma

1.55

0.60

2.0

1.5

1.23

1.26

g/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

290

1.32

0.60

3.4

2.9

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

107

1.48

0.60

2.2

2.1

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.59

0.0

1.1

—

(3025941) Bacteria identified in Stool by Culture

1.58

0.57

1.1

1.2

—

(40761535) Cells panel - Urine sediment

1.58

0.57

3.6

4.1

—

(3007164) IgA [Mass/volume] in Serum or Plasma

171

1.37

0.56

1.9

1.4

2.61

2.80

g/l

0.16

(3009542) Hematocrit [Volume Fraction] of Blood

896

0.65

0.56

34.0

19.6

39.38

40.19

0.58

851

(3008898) HLA-B27 [Presence]

1.57

0.54

1.0

1.1

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.48

0.54

2.3

2.0

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.48

0.54

3.1

1.8

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

346

1.27

0.48

6.0

4.3

35.16

35.74

g/l

0.27

332

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.58

0.48

1.4

1.8

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.49

0.48

2.1

2.0

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.43

0.46

2.4

2.8

0.16

0.08

e6/l

—

(40761511) CBC panel - Blood by Automated count

847

0.74

0.44

23.4

12.6

—

(40758558) Short blood count panel - Blood

214

0.75

0.44

10.5

6.8

—

(3027008) Opiates [Presence] in Urine

1.65

0.43

1.0

1.5

—

(3028300) Cannabinoids [Presence] in Urine

1.65

0.43

1.0

1.5

—

(3027944) Amphetamines [Presence] in Urine

1.59

0.43

1.0

1.5

—

(3000764) Benzodiazepines [Presence] in Urine

1.59

0.43

1.0

1.5

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.44

0.43

2.0

2.5

0.23

0.22

g/l

0.17

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

380

1.24

0.42

4.0

2.3

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.41

0.0

3.5

—

21.85

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.50

0.41

1.6

1.5

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.50

0.41

2.0

1.6

—

(3000991) Gas panel - Venous blood

1.34

0.40

2.4

4.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.38

0.40

1.4

1.6

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.38

0.39

4.9

3.7

1.21

1.23

mmol/l

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

184

1.25

0.34

2.0

1.8

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.40

0.32

1.3

1.7

—

(1761868) Lipid panel - Serum or Plasma

308

0.83

0.30

3.1

2.8

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

131

1.27

0.29

4.0

2.8

0.77

0.81

mmol/l

1.02

122

(40761536) Microorganisms panel - Urine sediment

1.35

0.29

3.3

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

150

1.25

0.29

1.5

2.3

2.51

2.45

mmol/l

0.59

130

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.27

0.28

2.6

1.8

—

(3022217) INR in Platelet poor plasma by Coagulation assay

353

1.18

0.28

21.3

14.4

1.26

1.30

inr

0.09

117

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

314

1.18

0.28

2.2

1.9

91.83

98.12

pmol/l

0.41

147

(3013512) EKG study

232

0.83

0.26

5.9

3.5

—

(3000492) Spirometry study

1.22

0.26

1.1

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.76

0.23

9.0

7.6

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.33

0.23

1.2

1.1

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.5

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.5

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.5

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.21

0.0

1.3

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.21

0.0

1.5

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.5

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

10.25

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.21

0.0

3.4

—

311.18

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.21

0.0

1.1

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

281

1.15

0.21

2.1

3.2

2.39

2.35

mmol/l

0.61

254

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

2.1

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.20

0.0

1.0

—

(3042936) Bacteria identified in Isolate by Culture

119

1.21

0.19

2.8

1.9

—

(3044640) Blood type and Crossmatch panel - Blood

254

1.14

0.19

3.1

1.9

—

(3019225) pH of Specimen

1.14

0.17

2.9

—

(40768797) Stomach Pathology biopsy report

118

0.83

0.15

1.1

1.2

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

848

0.85

0.14

26.1

15.5

71.57

73.43

umol/l

0.50

848

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

151

1.15

0.14

1.8

1.4

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

113

1.17

0.14

1.2

1.6

1.94

1.47

0.43

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

760

0.89

0.13

22.4

12.3

84.74

82.94

ml/min/173m2

0.30

613

(36304419) Bacteria [Presence] in Urine

230

1.12

0.13

3.2

2.6

—

(3021589) Normoblasts [#/volume] in Blood

378

1.10

0.13

18.1

8.8

0.00

e9/l

0.50

310

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

552

0.91

0.13

4.3

3.3

—

(3000494) Fungus identified in Specimen by Culture

1.18

0.12

3.3

1.3

—

(3020682) Albumin/Creatinine [Ratio] in Urine

205

0.91

0.09

4.3

3.8

8.26

9.62

mg/mmol

0.07

133

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

1.04

0.08

2.0

3.3

18.33

59.12

u/ml

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.81

0.08

1.4

1.5

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.08

0.08

1.9

2.4

5.71

4.88

ug/l

—

(36660697) Celiac disease serology panel - Serum

1.05

0.08

1.1

—

(21494755) Public health laboratory ask at order entry panel

1.03

0.07

1.4

1.3

—

(3003694) ABO and Rh group [Type] in Blood

223

0.93

0.06

2.1

1.5

—

(3012516) Albumin [Mass/volume] in Urine

188

1.08

0.06

3.3

3.2

3030.50

56.95

mg/l

0.48

124

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.12

0.05

2.2

5.1

102.90

103.70

mmol/l

—

(3009508) Creatinine [Moles/volume] in Urine

213

1.04

0.01

2.8

3.0

7.07

7.91

mmol/l

0.35

177

(3022145) Colonoscopy Study observation

108

1.02

0.00

1.9

1.5

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

178.78

—

(3028433) Virus identified in Specimen by Culture

0.00

-0.00

0.0

1.7

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.9

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

-0.00

0.0

1.2

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.8

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

6.2

—

1104.20

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

-0.00

0.0

1.2

—

6.12

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.5

—

(40768800) Prostate Pathology biopsy report

0.00

-0.00

0.0

1.3

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

-0.00

0.0

1.7

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

-0.00

0.0

1.8

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

820

1.00

-0.00

24.3

13.4

22.44

22.41

mg/l

0.00

636

(4146454) Self-monitoring of blood glucose

0.00

-0.00

0.0

3.6

—

(3051651) Icteric interference index of Serum or Plasma

0.00

-0.00

0.0

3.2

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

2.7

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.1

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

-0.00

0.0

1.0

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

-0.00

0.0

1.2

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

-0.00

0.0

1.5

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

2.7

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

1.3

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

20.4

—

2114.60

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.88

-0.00

1.4

1.5

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

1.02

-0.00

3.5

2.8

124.83

76.84

ng/l

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.0

—

(3044007) Cell count panel - Peritoneal fluid

0.00

-0.00

0.0

1.4

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3045788) Cell count panel - Pleural fluid

0.00

-0.00

0.0

1.4

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

-0.00

0.0

1.3

—

200.83

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

-0.00

0.0

1.0

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

0.84

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.4

—

1.70

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

-0.00

0.0

1.9

—

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_LYMPHNODES and mortality.

Females

Parameter	HR [95% CI]	p-value
CD2_BENIGN_LYMPHNODES	1.777 [1.35, 2.34]	< 0.001
Birth year	1.0 [0.99, 1.01]	0.901

During the follow-up period (1.1.1998 — 31.12.2019), 98 out of 393 females with CD2_BENIGN_LYMPHNODES died.

Males

Parameter	HR [95% CI]	p-value
CD2_BENIGN_LYMPHNODES	2.227 [1.65, 3.0]	< 0.001
Birth year	0.99 [0.98, 1.0]	0.086

During the follow-up period (1.1.1998 — 31.12.2019), 101 out of 327 males with CD2_BENIGN_LYMPHNODES died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_LYMPHNODES.

N-year risk	Females	Males
1	0.232%	0.424%
5	1.325%	2.999%
10	3.068%	7.057%
15	5.479%	13.282%
20	9.918%	22.164%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_LYMPHNODES – Benign neoplasm: Lymph nodes

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Benign neoplasm: Lymph nodes

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints