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Benign neoplasm of other and unspecified sites

DOID EFO Endpoint Browser PheWeb

CD2_BENIGN_OTHER_NOS

benign neoplasm: A neoplasm which is characterized by the absence of morphologic features associated with malignancy (severe cytologic atypia, tumor cell necrosis, and high mitotic rate). Benign neoplasms remain confined to the original site of growth and do not metastasize to other anatomic sites.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D36
  • Cause of death: ICD-10 — D36

2 out of 7 registries used, show all original rules.

903

4. Check minimum number of events

None

903

5. Include endpoints

1191

6. Filter based on genotype QC (FinnGen only)

1191

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D10-D36
Name in latin
Neoplasmata benigna locis aliis et non specificatis

Similar endpoints

↥

List of similar endpoints to Benign neoplasm of other and unspecified sites based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 9119 5174 3872
Only index persons 7706 4485 3221
Unadjusted period prevalence (%)
Whole population 0.13 0.15 0.11
Only index persons 0.15 0.16 0.12
Median age at first event (years)
Whole population 50.01 50.24 49.59
Only index persons 47.98 48.44 47.33

-FinnGen-

Key figures

All Female Male
Number of individuals 1191 695 496
Unadjusted period prevalence (%) 0.23 0.24 0.22
Median age at first event (years) 49.14 47.16 51.91

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1071
Matched controls
10709
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D36.1
ICD-10 Finland
Benign neoplasm: Peripheral nerves and autonomic nervous system
+∞
323.0
338
*
D36.7
ICD-10 Finland
Benign neoplasm: Other specified sites
1689.2
323.0
345
*
22899
ICD-8 Finland
Benign neoplasm of other and unspecified organs and tissues
+∞
108.2
102
*
22550
ICD-8 Finland
Benign neoplasm of brain and other parts of nervous system, Peripheral nerves
+∞
102.8
97
*
D36.0
ICD-10 Finland
Benign neoplasm: Lymph nodes
+∞
88.8
84
*
ACB19
NOMESCO Finland
Excision of lesion of peripheral nerve other or unspecified
313.9
58.9
59
*
D36.9
ICD-10 Finland
Benign neoplasm: Benign neoplasm of unspecified site
599.2
58.2
57
*
2258X
ICD-9 Finland
Benign neoplasm of brain and other parts of nervous system, Other specified sites of nervous system
+∞
55.7
53
*
DHB10
NOMESCO Finland
Excision of lesion of internal nose
42.6
30.1
37
9
Q85.00
ICD-10 Finland
Neurofibromatosis, type 1
107.0
19.6
21
*
Q85.09
ICD-10 Finland
Unspecified neurofibromatosis
107.0
19.6
21
*
D48.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Connective and other soft tissue
6.3
18.8
50
82
D48.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Peripheral nerves and autonomic nervous system
193.2
18.6
19
*
D33.45
ICD-10 Finland
Benign Schwannom in the nerve root of the spinal cord
27.2
17.9
24
9
DHB00
NOMESCO Finland
Excision of lesion of external nose
12.2
17.4
31
26
2401
FHL
Nerve exploration (includes biopsy and removal of local change)
40.7
16.4
20
5
DHA10
NOMESCO Finland
Biopsy of cavity of nose
9.9
15.2
30
31
D14.0
ICD-10 Finland
Benign neoplasm: Middle ear, nasal cavity and accessory sinuses
9.9
15.2
30
31
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.5
15.0
119
501
ACB99
NOMESCO Finland
Other operation for lesion of peripheral nerve: other or unspecified
+∞
14.6
14
*
N03AX16
ATC
pregabalin; oral
1.9
14.6
274
1675
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.7
13.8
100
400
D48.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Neoplasm of uncertain or unknown behaviour, unspecified
5.7
13.4
38
69
NDR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of wrist or hand
6.8
13.3
33
50
R22.4
ICD-10 Finland
Localized swelling, mass and lump, lower limb
4.6
13.3
46
104
9560/0-C72.9
ICD-O-3
Schwannoma, NOS, of nervous system, NOS
+∞
12.5
12
*
Q85.0
ICD-10 Finland
Neurofibromatosis (nonmalignant)
131.5
12.5
13
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
12.2
288
1881
N03AX12
ATC
gabapentin; oral
2.0
12.0
176
978
ZXA05
NOMESCO Finland
Left side
1.7
10.5
277
1854
ZXA00
NOMESCO Finland
Right side
1.7
10.3
283
1913
D21.2
ICD-10 Finland
Benign neoplasm: Connective and other soft tissue of lower limb, including hip
13.3
10.2
17
13
R22.3
ICD-10 Finland
Localized swelling, mass and lump, upper limb
4.7
9.4
31
68
2899X
ICD-9 Finland
Other diseases of blood and blood-forming organs, Unspecified diseases of blood and blood-forming organs
+∞
9.4
9
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
9.2
349
2547
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
2.3
9.2
81
361
D17.2
ICD-10 Finland
Benign lipomatous neoplasm of skin and subcutaneous tissue of limbs
4.1
9.2
34
84
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
6.0
9.1
24
41
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.5
9.1
69
286
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
3.1
9.1
49
165
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.1
9.0
107
545
R22.9
ICD-10 Finland
Localized swelling, mass and lump, unspecified
2.3
8.9
81
366
S18
ICPC
Laceration/cut
1.5
8.8
415
3175
WX110
NOMESCO Finland
Local anesthesy
1.5
8.7
688
5864
R03AC02
ATC
salbutamol; inhalant
1.5
8.6
515
4140
Q85.01
ICD-10 Finland
Neurofibromatosis, type 2
90.7
8.4
9
*
ABB00
NOMESCO Finland
Excision of lesion of spinal canal
12.9
8.4
14
11
ACB15
NOMESCO Finland
Excision of local lesion of tibial nerve
+∞
8.3
8
*
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
2.9
8.3
49
175
R51
ICD-10 Finland
Headache
2.7
8.3
54
206
R22.2
ICD-10 Finland
Localized swelling, mass and lump, trunk
3.2
8.2
41
131
R51.80
ICD-10 Finland
Headache
1.8
8.2
142
830
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
5.2
8.2
24
47
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.6
8.1
210
1385
N02BE01
ATC
paracetamol; systemic, rectal
1.6
8.1
887
8043
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
2.4
8.1
65
278
D33.30
ICD-10 Finland
Acoustic neuroma
10.1
8.0
15
15
NK1AT
NOMESCO Finland
Muscle biopsy with ultrasound guidance
13.1
7.9
13
10
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
2.8
7.9
48
176
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.6
7.7
194
1272
A02BC03
ATC
lansoprazole; oral
1.5
7.7
294
2134
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.2
7.6
75
353
M79.6
ICD-10 Finland
Pain in limb
1.5
7.6
344
2590
WX302
NOMESCO Finland
Thoracal epidural anesthesy
2.4
7.6
62
268
PJA10
NOMESCO Finland
Exploration of lymph nodes
5.5
7.5
21
39
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
4.2
7.5
27
66
D21.1
ICD-10 Finland
Benign neoplasm: Connective and other soft tissue of upper limb, including shoulder
5.3
7.4
21
40
D23.3
ICD-10 Finland
Benign neoplasm: Skin of other and unspecified parts of face
3.2
7.4
36
114
Z31.5
ICD-10 Finland
Genetic counselling
2.5
7.3
55
228
ACB18
NOMESCO Finland
Excision of local lesion of brachial plexus
+∞
7.3
7
*
N02AX02
ATC
tramadol; systemic, rectal
1.4
7.2
416
3282
SPAT1153
SPAT
Removal of sutures
1.5
6.9
314
2359
A02BC02
ATC
pantoprazole; systemic
1.4
6.9
639
5483
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
4.7
6.7
21
45
P01AB01
ATC
metronidazole; oral, rectal
1.4
6.7
386
3030
ABD30
NOMESCO Finland
Implantation of spinal stimulation device
6.5
6.6
16
25
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
2.9
6.6
38
133
A02BC05
ATC
esomeprazole; systemic
1.4
6.6
395
3124
UJF32
NOMESCO Finland
Coloscopy
1.5
6.6
248
1785
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
6.6
424
3397
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
5.4
6.5
18
34
M01AC06
ATC
meloxicam; systemic, rectal
1.4
6.5
349
2705
R07.4
ICD-10 Finland
Chest pain, unspecified
1.5
6.4
252
1834
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
6.0
6.3
16
27
D21.9
ICD-10 Finland
Benign neoplasm: Connective and other soft tissue, unspecified
18.1
6.3
9
5
Q85.1
ICD-10 Finland
Tuberous sclerosis
+∞
6.3
6
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.0
6.2
72
364
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.5
6.2
193
1332
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
2.8
6.1
37
137
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.5
6.1
259
1910
D37.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Liver, gallbladder and bile ducts
4.2
6.0
21
51

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
551
3900
1.77
20.10
2.3
2.1
—
—
—
0
0
163
841
2.09
15.39
1.4
1.4
—
—
—
0
0
215
1243
1.89
14.62
1.4
1.3
—
—
—
0
0
576
4552
1.51
11.00
4.7
4.0
—
—
—
0
0
840
7244
1.54
10.21
4.6
4.1
11.2
12.2
mm/h
1.41
773
6699
605
4887
1.48
10.04
6.3
5.7
0.0
0.0
e9/l
0.79
536
4251
597
4824
1.48
9.80
6.9
6.8
1.2
1.2
mmol/l
0.07
520
4080
601
4870
1.47
9.68
6.3
5.7
0.6
0.6
e9/l
0.34
531
4224
503
3945
1.48
9.52
8.4
9.2
1.2
1.2
inr
0.08
131
1139
618
5046
1.47
9.51
6.4
6.0
0.2
0.2
e9/l
0.56
558
4460
613
5002
1.46
9.43
6.3
5.8
1.8
1.9
e9/l
1.70
550
4425
681
5673
1.47
9.40
9.4
9.0
4.0
4.1
e9/l
0.46
608
4989
544
4383
1.44
8.70
7.0
6.0
1.2
1.2
mmol/l
0.47
502
3974
620
5143
1.43
8.32
6.7
6.1
10.7
11.4
umol/l
0.90
589
4901
678
5723
1.43
8.21
5.6
4.8
6.6
6.7
mmol/l
0.39
646
5368
298
2164
1.50
8.00
5.5
4.4
—
—
—
0
0
169
1091
1.64
7.57
7.4
8.3
5.2
5.1
kpa
0.67
162
1047
169
1092
1.64
7.54
7.3
8.3
12.6
12.1
kpa
0.52
164
1050
168
1094
1.62
7.26
7.4
8.3
1.4
1.2
mmol/l
0.31
127
863
144
904
1.67
7.18
2.8
2.0
359.5
373.5
nmol/l
0.39
132
834
514
4203
1.39
7.08
5.0
4.8
35.3
35.5
g/l
0.49
468
3913
1047
9726
1.63
7.03
17.9
14.2
22.6
24.0
mg/l
0.72
851
7702
847
7543
1.43
6.95
8.9
7.5
75.7
78.6
u/l
0.99
801
7097
326
2476
1.44
6.81
3.7
3.8
90.0
90.7
%
0.21
319
2414
838
7466
1.41
6.72
4.7
4.0
14.9
14.8
pmol/l
0.51
771
6810
381
2989
1.40
6.59
2.3
2.2
241.6
247.8
u/l
0.03
358
2813
393
3102
1.40
6.56
2.9
2.5
62.6
55.9
u/l
0.60
366
2872
372
2911
1.40
6.52
4.3
3.9
7.4
7.4
ph
0.18
60
550
971
8910
1.49
6.46
5.4
4.8
1.9
2.0
mu/l
0.66
888
8162
95
555
1.77
6.14
3.4
3.4
4.3
4.5
pmol/l
1.83
83
495
1067
10025
1.62
6.03
20.3
16.3
139.8
139.6
mmol/l
1.02
1040
9765
416
3352
1.37
6.01
3.5
3.5
2.4
2.4
mmol/l
0.37
361
2944
386
3083
1.37
5.87
2.6
2.4
—
—
—
0
0
1068
10050
1.61
5.83
20.2
16.5
4.0
4.0
mmol/l
0.88
1035
9778
551
4656
1.34
5.78
6.3
5.8
56.8
57.4
%
0.49
517
4366
557
4719
1.34
5.72
6.7
6.0
28.1
27.8
%
0.28
523
4401
544
4602
1.34
5.61
7.0
6.3
8.7
8.6
%
0.22
512
4316
778
6942
1.35
5.53
4.1
3.8
—
—
—
0
0
539
4577
1.32
5.32
6.6
5.9
2.9
2.8
%
0.38
507
4266
453
3762
1.33
5.19
4.0
3.7
26.5
44.4
ng/l
1.10
300
2623
161
1123
1.50
5.12
1.8
1.7
—
—
—
0
0
299
2338
1.37
5.08
2.4
2.3
—
—
—
0
0
46
227
2.07
4.97
1.5
1.3
12.5
10.8
u/l
0.28
38
181
102
649
1.63
4.85
6.1
5.7
—
—
—
0
0
521
4442
1.31
4.85
6.6
5.9
0.7
0.7
%
1.67
489
4148
192
1404
1.44
4.79
2.1
2.1
—
—
—
0
0
26
103
2.56
4.65
1.4
1.4
—
—
—
0
0
747
6710
1.30
4.59
5.0
4.3
—
—
—
0
0
136
939
1.51
4.54
2.0
2.2
0.2
0.2
g/l
0.43
127
880
331
2678
1.33
4.41
4.6
4.1
—
—
—
0
0
94
605
1.60
4.29
1.3
1.3
140.2
223.6
u/ml
0.65
87
559
220
1684
1.38
4.20
1.3
1.3
36.0
30.7
iu/ml
0.19
66
542
90
580
1.60
4.10
9.6
9.8
0.7
0.7
%
0.30
90
575
90
584
1.59
3.99
9.4
9.7
1.2
1.4
%
0.68
90
579
117
805
1.50
3.99
4.2
3.3
—
—
—
0
0
305
2474
1.31
3.94
6.8
6.6
—
—
—
0
0
360
2988
1.29
3.91
3.4
3.1
—
—
—
0
0
272
2173
1.33
3.91
1.8
1.7
1.1
1.2
mg/l
0.21
211
1679
23
94
2.48
3.90
1.6
1.5
—
—
—
0
0
315
2571
1.31
3.88
5.1
3.9
0.0
0.0
estimate
1.08
100
870
44
237
1.89
3.78
2.0
2.1
6053.7
3350.3
u/l
—
9
93
150
1099
1.42
3.70
1.3
1.3
—
—
—
0
0
203
1566
1.36
3.68
3.5
3.4
0.8
0.8
mmol/l
0.41
192
1468
179
1359
1.37
3.58
1.2
1.2
—
—
—
0
0
390
3300
1.27
3.58
6.6
5.7
—
—
—
0
0
171
1290
1.38
3.56
4.3
5.5
1.0
1.0
mmol/l
0.02
160
1190
325
2691
1.29
3.55
3.1
3.0
0.7
0.5
e6/l
0.36
264
2054
62
378
1.68
3.54
3.1
3.3
76.1
10501.0
u/ml
0.82
49
326
266
2146
1.31
3.54
1.3
1.2
1.1
1.7
u/ml
1.05
68
570
207
1616
1.34
3.46
1.4
1.2
10.2
12.0
u/ml
0.15
86
638
175
1333
1.37
3.43
1.4
1.3
512.9
563.5
titre
0.12
34
285
76
494
1.58
3.38
7.9
10.4
24.2
24.4
mmol/l
0.23
69
468
153
1145
1.39
3.35
2.2
2.3
170.2
126.9
ug/g
0.51
128
912
150
1120
1.39
3.33
2.7
2.7
10.5
8.2
umol/l
0.39
127
983
705
6416
1.24
3.31
5.2
4.5
648.4
2598.2
e6/l
1.12
11
95
868
8093
1.27
3.26
20.7
17.4
13.7
13.7
%
0.08
853
7924
539
4771
1.24
3.26
5.8
4.9
0.0
0.0
estimate
0.50
102
904
24
110
2.21
3.20
1.3
1.3
—
—
nmol/l
—
0
0
1059
10151
1.39
3.18
16.9
13.5
—
—
—
0
0
15
55
2.75
3.16
5.4
7.0
—
—
—
0
0
313
2614
1.27
3.15
3.0
3.0
—
—
—
0
0
537
4767
1.23
3.11
4.5
3.6
0.0
0.0
estimate
0.00
100
897
109
779
1.44
3.10
7.0
8.4
—
—
—
0
0
39
217
1.82
3.08
1.3
1.3
1290.2
1018.7
e6/l
0.11
33
173
39
217
1.82
3.08
1.2
1.2
6.1
50.7
e6/l
0.94
30
168
164
1259
1.35
3.07
24.3
24.4
1.2
1.3
inr
0.24
24
165
6
8
7.53
3.05
1.7
1.1
—
—
—
0
0
18
74
2.45
3.05
2.8
2.2
1102.4
800.3
e6/l
—
5
28
137
1023
1.38
3.05
3.7
4.1
61.2
24.5
ug/l
0.28
113
838
94
656
1.47
3.03
2.9
2.5
31.5
22.7
au/ml
—
10
36
250
2040
1.29
3.02
2.6
2.5
6.0
6.3
e6/l
0.13
221
1810
1078
10383
1.40
2.97
12.3
10.3
25.5
26.3
u/l
1.09
1048
10026
74
494
1.53
2.96
2.5
2.4
—
—
—
0
0
122
902
1.39
2.89
2.9
2.3
37.3
39.2
u/l
0.09
97
761
292
2443
1.26
2.87
2.5
2.1
3.0
3.0
mg/l
0.02
242
2080
474
4180
1.22
2.86
2.9
2.7
124.2
128.1
ug/l
0.12
432
3850
19
83
2.31
2.85
1.9
2.1
1.2
1.1
e9/l
0.09
12
47
539
4822
1.22
2.80
4.5
3.6
0.0
0.0
estimate
0.34
104
875
266
2209
1.26
2.78
4.6
3.6
—
—
—
0
0
394
3424
1.23
2.72
3.6
3.6
46.4
114.6
e6/l
1.91
303
2461
1114
10815
1.46
2.70
26.3
20.9
254.0
250.1
e9/l
1.16
1095
10556
224
1828
1.28
2.70
1.9
1.8
1105.0
1187.8
nmol/l
0.60
162
1375
106
775
1.40
2.69
2.7
3.6
84.6
84.8
ng/l
0.01
89
679
58
375
1.57
2.69
9.1
4.5
—
—
—
0
0
49
304
1.64
2.68
1.7
1.6
257.5
300.3
mu/l
0.87
43
275
112
827
1.39
2.68
2.2
2.5
5.8
7.1
ug/l
0.38
101
732
1114
10819
1.46
2.65
26.3
20.8
90.8
91.1
fl
1.03
1099
10663
1114
10822
1.45
2.62
26.4
20.9
4.5
4.5
e12/l
0.09
1091
10539
1114
10823
1.45
2.60
26.4
20.9
6.6
6.7
e9/l
1.84
1091
10532
1114
10825
1.45
2.58
26.6
21.0
134.6
135.2
g/l
0.61
1099
10668
57
371
1.56
2.58
1.4
1.2
0.2
1.1
u/ml
—
10
30
15
62
2.44
2.54
2.1
2.0
19.6
14.0
%
—
9
29
35
201
1.76
2.54
4.7
4.0
—
—
—
0
0
305
2603
1.23
2.48
1.7
1.7
1.4
1.4
mmol/l
0.39
261
2203
1113
10822
1.43
2.48
26.3
20.8
30.2
30.3
pg
1.85
1098
10664
25
130
1.94
2.46
1.6
1.2
—
—
—
0
0
92
672
1.40
2.37
2.6
2.2
11.8
13.2
nmol/l
0.87
84
597
7
17
4.14
2.36
1.3
1.1
—
—
—
0
0
27
147
1.86
2.34
1.4
1.7
0.7
0.9
g/l
0.47
22
114
40
245
1.65
2.33
1.2
1.2
609.8
493.1
mg/l
0.41
40
232
295
2527
1.22
2.30
2.4
2.6
2143.0
5839.8
umol/l
1.64
264
2195
228
1900
1.25
2.30
1.4
1.5
2.2
2.5
g/l
1.45
135
1177
188
1532
1.27
2.29
2.2
2.4
13.2
13.1
umol/l
0.09
168
1413
228
1901
1.25
2.29
4.3
3.7
163.3
352.0
ng/l
1.53
181
1479
73
515
1.44
2.29
8.4
11.4
—
—
—
0
0
85
620
1.40
2.22
1.2
1.2
—
—
—
0
0
46
296
1.58
2.22
1.5
1.4
249.8
285.3
ug/g
0.68
33
178
108
822
1.35
2.18
5.0
4.1
0.9
0.9
%
0.05
30
247
33
196
1.70
2.17
1.2
1.3
—
—
—
0
0
57
389
1.49
2.12
1.5
1.3
28.7
29.9
iu/l
0.08
45
334
18
88
2.06
2.12
5.1
4.7
42.1
56.5
u/ml
—
6
26
22
116
1.91
2.11
1.3
1.3
—
—
—
0
0
336
2938
1.20
2.10
3.2
3.1
36.5
91.9
e6/l
1.34
272
2284
34
207
1.66
2.06
1.4
1.7
—
—
—
0
0
323
2820
1.20
2.05
4.1
3.9
—
—
—
0
0
106
813
1.33
2.05
3.2
3.0
122.2
194.4
ng/l
2.79
96
742
98
746
1.34
1.99
1.1
1.2
—
—
—
0
0
50
337
1.50
1.99
7.6
3.9
1.1
1.4
mmol/l
2.15
50
329
23
126
1.84
1.99
1.3
1.3
0.5
0.6
nmol/l
1.19
23
116
12
51
2.37
1.95
1.4
1.9
—
—
—
0
0
97
743
1.33
1.90
4.7
4.0
0.7
0.5
%
0.26
20
179
939
9000
1.20
1.88
6.1
5.7
39.2
39.9
mmol/mol
1.62
867
8361
247
2119
1.21
1.88
5.1
3.9
1.0
1.0
kg/l
0.16
30
302
75
553
1.38
1.88
1.2
1.2
—
—
—
0
0
98
756
1.32
1.84
2.8
2.8
9.6
10.8
g/l
2.58
89
697
442
3996
1.17
1.84
2.1
2.0
97.1
95.3
pmol/l
0.38
217
2068
6
17
3.54
1.84
1.0
1.0
—
—
—
0
0
132
1061
1.27
1.83
3.0
2.6
1.7
1.8
%
1.30
113
952
81
608
1.36
1.82
1.7
1.7
1.6
1.4
g/l
0.27
68
561
985
9494
1.22
1.81
4.9
4.5
6.0
5.9
mmol/l
0.08
895
8652
35
225
1.57
1.75
1.2
1.2
4.2
3.8
mmol/l
1.18
35
213
215
1836
1.21
1.72
3.1
3.0
2.5
2.5
mmol/l
1.19
184
1634
145
1189
1.25
1.71
1.6
1.4
—
—
—
0
0
11
48
2.30
1.70
1.1
1.2
—
—
—
0
0
290
2549
1.18
1.69
1.4
1.4
—
—
—
0
0
153
1267
1.24
1.66
1.7
1.6
—
—
—
0
0
98
771
1.30
1.62
4.9
4.2
0.2
0.1
%
0.08
26
223
225
1941
1.20
1.62
2.8
2.7
509.6
551.1
mosm/kgh2o
2.42
194
1676
49
345
1.44
1.62
1.6
1.6
—
—
—
0
0
59
432
1.38
1.58
1.3
1.2
—
—
—
0
0
11
50
2.21
1.57
1.3
1.3
—
—
—
0
0
468
4292
1.15
1.55
11.0
9.4
0.0
0.0
e9/l
0.82
397
3539
16
85
1.89
1.55
1.0
1.2
—
—
—
0
0
92
723
1.30
1.55
4.9
4.3
0.0
0.6
%
0.64
21
188
40
274
1.48
1.53
1.3
1.2
96.0
82.2
titre
—
5
23
23
138
1.68
1.52
2.3
2.7
—
—
—
0
0
157
1319
1.22
1.50
2.2
2.4
23.6
22.9
%
0.20
125
1120
9
37
2.44
1.48
3.8
3.1
—
—
—
0
0
39
269
1.47
1.45
1.6
1.3
203.3
224.9
miu/ml
0.18
24
128
6
22
2.74
1.43
2.2
1.9
—
—
—
0
0
317
2846
1.16
1.40
3.1
3.0
891.8
1305.5
ng/l
2.03
263
2423
98
788
1.27
1.40
2.7
2.9
65.4
66.8
g/l
1.03
89
718
43
306
1.42
1.38
1.2
1.2
—
—
—
0
0
107
874
1.25
1.34
3.6
3.2
2.1
1.9
mmol/l
0.21
93
695
23
144
1.61
1.32
2.1
1.7
—
—
—
0
0
9
43
2.10
1.30
3.8
2.8
—
—
—
0
0
125
1045
1.22
1.27
1.8
1.6
—
—
—
0
0
15
84
1.80
1.27
1.1
1.2
0.0
0.8
u/ml
—
9
41
9
44
2.05
1.27
1.1
1.1
126.6
525.9
u/l
—
9
39
101
826
1.24
1.26
4.7
3.8
—
—
—
0
0
11
203
0.54
1.25
3.2
3.7
17.6
24.4
mg/l
—
5
132
164
1411
1.19
1.24
2.2
2.4
2.3
2.3
g/l
0.06
149
1318
261
2331
1.15
1.24
1.6
1.5
20.2
20.9
nmol/l
0.29
220
1984
84
675
1.26
1.23
1.7
1.4
—
—
—
0
0
5
19
2.64
1.21
1.8
1.3
—
—
—
0
0
29
197
1.48
1.20
3.7
2.4
18.1
16.0
%
2.05
17
98
16
95
1.69
1.14
1.1
1.2
—
—
—
0
0
77
620
1.26
1.12
4.8
3.7
5.3
5.1
kpa
0.51
69
582
76
611
1.26
1.12
4.9
3.7
7.4
7.4
ph
0.78
11
76
323
3527
0.88
1.11
3.1
2.8
—
—
—
0
0
1009
9853
1.16
1.05
5.2
4.9
2.8
2.8
mmol/l
0.05
924
9077
81
664
1.24
1.03
2.3
2.4
—
—
—
0
0
38
281
1.36
1.03
2.3
3.4
—
—
—
0
0
175
1540
1.16
1.03
2.8
2.8
3.0
2.5
e6/l
0.26
104
854
28
196
1.44
1.03
3.1
2.1
138.2
129.6
g/l
0.95
22
145
25
171
1.47
1.03
1.2
1.4
—
—
—
0
0
38
282
1.36
1.01
1.2
1.2
—
1227.8
—
0
9
15
91
1.66
1.00
1.3
1.3
—
—
—
0
0
9
48
1.88
1.00
1.6
3.4
—
—
—
0
0
7
35
2.01
1.00
1.6
2.9
—
—
—
0
0
234
2107
1.14
1.00
1.7
1.7
29189689.8
18955058.5
pmol/l
0.13
185
1741
29
206
1.42
0.99
4.8
4.9
2.7
2.7
mmol/l
0.02
22
141
112
953
1.19
0.99
3.9
4.1
—
—
—
0
0
23
156
1.48
0.99
1.1
1.1
1.1
2.2
u/ml
—
9
62
20
295
0.67
0.97
1.4
1.6
—
—
—
0
0
49
381
1.30
0.96
1.1
1.1
—
0.9
u/ml
—
0
5
9
50
1.81
0.96
1.9
2.8
2815.4
992.7
u/ml
—
9
50
95
799
1.21
0.96
3.9
2.7
65.6
71.8
e9/l
0.94
73
612
990
9677
1.14
0.91
4.6
4.4
4.7
4.7
mmol/l
0.01
913
8974
18
118
1.53
0.91
1.5
1.7
—
—
—
0
0
18
118
1.53
0.91
1.5
1.7
—
—
—
0
0
18
118
1.53
0.91
1.5
1.7
—
—
—
0
0
18
118
1.53
0.91
1.5
1.7
—
—
—
0
0
20
135
1.49
0.89
2.7
2.6
—
—
—
0
0
82
686
1.21
0.88
1.5
1.4
—
—
—
0
0
24
169
1.43
0.88
3.5
2.8
—
—
—
0
0
6
30
2.00
0.87
1.2
1.2
2.5
1.3
%
—
6
23
19
275
0.69
0.86
1.5
1.6
—
—
—
0
0
21
298
0.70
0.86
1.5
1.6
—
—
—
0
0
39
300
1.31
0.85
2.9
3.5
50.4
42.1
mg/l
0.20
33
240
39
300
1.31
0.85
2.9
3.5
111.8
71.4
mg/l
0.36
33
240
15
227
0.66
0.85
1.6
1.6
—
—
—
0
0
13
80
1.63
0.84
1.4
1.4
37.0
29.3
%
—
8
50
21
297
0.70
0.84
1.4
1.6
—
—
—
0
0
21
297
0.70
0.84
1.4
1.5
—
—
—
0
0
21
146
1.45
0.82
1.1
1.2
2.9
6.8
u/ml
—
9
61
33
249
1.33
0.82
1.2
1.3
—
—
—
0
0
6
32
1.88
0.82
1.0
1.5
—
—
—
0
0
285
2632
1.11
0.80
3.8
3.3
—
—
—
0
0
912
8893
1.11
0.80
18.4
15.3
40.1
39.8
%
0.56
629
6393
0
24
0.00
0.79
0.0
3.3
—
—
—
0
0
19
131
1.46
0.78
1.1
1.0
0.1
2.9
u/ml
—
5
51
12
187
0.64
0.78
1.9
1.6
—
—
—
0
0
0
27
0.00
0.77
0.0
1.1
—
—
—
0
0
0
28
0.00
0.76
0.0
1.0
—
—
—
0
0
23
166
1.39
0.76
1.5
1.3
—
—
—
0
0
16
108
1.49
0.73
5.6
4.1
—
—
—
0
0
7
38
1.85
0.73
1.9
2.3
26.2
229.1
ug/l
—
7
33
11
68
1.62
0.72
1.2
1.2
—
—
—
0
0
7
40
1.75
0.71
34.9
33.2
108.7
122.9
ug/l
—
7
33
15
101
1.49
0.70
1.1
1.3
—
—
—
0
0
9
58
1.56
0.70
1.1
1.2
—
—
—
0
0
14
93
1.51
0.69
1.2
1.1
—
—
—
0
0
19
135
1.41
0.69
1.1
1.0
4.8
7.0
u/ml
—
7
62
92
799
1.16
0.69
3.8
3.8
1.2
1.2
mmol/l
0.22
77
695
20
144
1.40
0.68
1.2
1.2
—
—
—
0
0
312
2919
1.09
0.68
5.0
4.8
2.0
2.4
ug/l
1.31
275
2606
17
119
1.43
0.67
1.1
1.2
—
57.1
—
0
7
5
93
0.54
0.67
1.2
1.2
—
—
—
0
0
7
43
1.63
0.67
1.6
1.8
—
—
—
0
0
13
86
1.52
0.66
3.4
3.2
3.2
18.4
mg/l
—
7
62
38
304
1.26
0.65
1.9
1.5
0.2
0.2
g/l
1.05
38
292
14
95
1.48
0.64
1.9
2.2
—
—
—
0
0
5
29
1.73
0.64
1.2
1.1
18.0
34.8
%
—
5
24
6
101
0.59
0.62
1.2
1.2
—
—
—
0
0
6
101
0.59
0.62
1.2
1.1
—
—
—
0
0
25
191
1.32
0.61
3.5
4.0
57.0
58.0
%
0.12
25
191
8
51
1.57
0.60
1.1
1.1
—
—
—
0
0
8
51
1.57
0.60
1.0
1.5
4.3
6.1
ug/l
—
8
40
168
1535
1.11
0.60
1.8
1.8
—
—
—
0
0
8
52
1.54
0.59
3.0
2.5
—
—
—
0
0
43
517
0.83
0.58
1.9
1.7
—
—
—
0
0
14
98
1.43
0.56
1.6
2.2
—
—
—
0
0
6
38
1.58
0.54
16.8
16.8
—
—
—
0
0
9
60
1.50
0.54
1.3
1.5
—
—
—
0
0
16
117
1.37
0.52
1.8
1.5
0.2
0.3
nmol/l
—
8
92
9
133
0.67
0.52
1.1
1.5
—
—
—
0
0
6
40
1.50
0.51
1.2
1.3
—
—
—
0
0
27
216
1.26
0.49
1.6
3.2
28.7
33.9
umol/l
0.87
22
182
976
9617
1.08
0.48
4.6
4.3
1.5
1.5
mmol/l
0.99
897
8852
11
154
0.71
0.47
1.0
1.1
—
—
—
0
0
11
154
0.71
0.47
1.0
1.1
—
—
—
0
0
840
8239
1.07
0.45
23.8
18.3
331.9
332.3
g/l
0.68
835
8174
14
103
1.36
0.45
1.3
1.3
—
—
—
0
0
20
156
1.29
0.45
1.8
1.6
—
—
—
0
0
23
183
1.26
0.45
3.1
3.7
3.9
4.3
e9/l
0.34
23
183
7
51
1.37
0.44
1.0
1.0
—
—
—
0
0
9
129
0.70
0.43
1.1
1.4
—
—
—
0
0
9
130
0.69
0.43
1.1
1.4
—
—
—
0
0
106
966
1.11
0.43
1.5
1.5
—
—
—
0
0
5
31
1.62
0.43
1.0
1.1
157.6
310.2
pmol/l
—
5
21
5
32
1.56
0.42
1.4
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
3.5
—
—
—
0
0
0
15
0.00
0.41
0.0
3.5
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
6.1
—
—
—
0
0
5
34
1.47
0.40
1.2
1.2
64.8
52.6
%
—
5
24
18
141
1.28
0.40
1.1
1.2
—
—
—
0
0
82
906
0.90
0.40
1.3
1.4
—
—
—
0
0
8
61
1.31
0.39
1.0
1.1
—
—
—
0
0
10
71
1.41
0.39
1.4
1.6
0.9
1.0
g/l
—
10
71
37
316
1.18
0.39
1.9
1.5
1.2
1.2
g/l
0.31
37
301
36
307
1.18
0.39
8.0
10.3
—
—
—
0
0
9
66
1.37
0.38
4.3
2.1
—
—
—
0
0
15
192
0.78
0.38
1.9
2.3
—
—
—
0
0
49
430
1.15
0.37
2.3
1.8
—
—
—
0
0
27
225
1.20
0.37
3.1
3.8
—
—
—
0
0
30
354
0.84
0.37
1.0
1.1
—
—
—
0
0
5
37
1.35
0.37
1.0
1.1
—
—
—
0
0
941
9289
1.06
0.36
4.1
3.9
1.3
1.3
mmol/l
0.33
863
8510
51
451
1.14
0.36
5.4
3.8
—
—
—
0
0
17
135
1.26
0.35
1.2
1.2
—
—
—
0
0
9
124
0.72
0.35
1.8
2.0
—
—
—
0
0
6
43
1.40
0.35
1.0
1.2
27.6
31.3
umol/l
—
6
43
11
82
1.34
0.34
1.0
1.4
—
—
—
0
0
6
45
1.33
0.33
1.0
1.0
—
0.4
—
0
5
74
674
1.10
0.33
2.6
3.2
3.8
4.1
e9/l
0.65
58
531
20
164
1.22
0.32
1.2
1.1
—
—
—
0
0
18
219
0.82
0.31
3.0
2.2
—
—
—
0
0
22
184
1.20
0.30
1.2
1.3
61.0
64.3
mmol/l
0.15
17
154
13
102
1.28
0.30
2.2
3.7
—
—
—
0
0
13
102
1.28
0.30
2.3
1.8
—
—
—
0
0
312
3011
1.05
0.29
3.2
3.1
7.1
7.4
mmol/l
0.63
266
2519
294
2836
1.05
0.28
3.3
3.2
693.4
316.1
mg/l
0.50
192
1786
11
85
1.30
0.28
1.5
1.4
—
—
—
0
0
50
451
1.11
0.28
3.1
3.1
24.2
24.2
mmol/l
0.02
45
406
22
187
1.18
0.26
1.7
1.6
—
—
—
0
0
11
86
1.28
0.26
1.0
1.3
—
—
—
0
0
164
1720
0.95
0.25
3.3
2.9
0.7
0.8
ug/l
0.42
112
1099
6
85
0.70
0.24
1.0
1.2
354.7
384.8
nmol/l
—
6
74
6
85
0.70
0.24
1.2
2.1
—
2.0
—
0
6
79
845
0.93
0.23
1.4
1.4
—
—
—
0
0
16
189
0.84
0.22
1.2
1.3
—
—
—
0
0
5
42
1.19
0.21
1.6
1.3
—
—
—
0
0
5
42
1.19
0.21
1.0
1.3
—
1.4
%
—
0
9
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
15
126
1.19
0.21
2.1
1.2
—
—
—
0
0
10
80
1.25
0.20
1.5
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
27
240
1.13
0.20
2.2
1.7
16331.1
14364.6
e6/l
0.11
21
179
9
111
0.81
0.20
1.0
1.1
—
—
—
0
0
15
176
0.85
0.20
1.1
1.3
188.4
268.9
u/ml
—
7
106
30
269
1.12
0.20
1.1
1.2
—
—
—
0
0
76
715
1.07
0.19
1.7
1.6
—
—
—
0
0
17
147
1.16
0.18
4.2
3.6
1.3
1.4
%
0.06
12
123
61
651
0.93
0.18
1.3
1.2
132.7
143.1
iu/ml
0.08
24
262
58
620
0.93
0.18
3.5
2.8
—
—
—
0
0
14
119
1.18
0.17
1.4
1.6
58.6
61.3
%
—
9
79
8
71
1.13
0.16
1.3
1.0
—
—
—
0
0
23
206
1.12
0.16
3.9
3.2
0.8
0.8
nmol/l
0.65
18
162
8
72
1.11
0.16
1.3
1.6
9.4
12.0
umol/l
—
8
67
8
72
1.11
0.16
1.3
1.1
—
—
—
0
0
8
73
1.10
0.15
1.3
1.2
—
—
—
0
0
11
93
1.18
0.14
1.5
1.4
169932.0
106429.8
e6/l
—
5
51
8
98
0.82
0.13
2.0
2.4
—
—
—
0
0
46
489
0.94
0.13
5.7
3.7
—
—
—
0
0
45
423
1.07
0.13
1.6
1.9
1.5
1.5
g/l
0.07
36
372
41
385
1.07
0.12
2.1
2.6
—
—
—
0
0
11
95
1.16
0.11
1.3
1.4
—
—
—
0
0
5
45
1.11
0.10
2.4
2.2
48.8
53.4
umol/l
—
5
33
16
176
0.91
0.09
1.0
1.2
—
—
—
0
0
44
419
1.05
0.09
1.0
1.1
—
—
—
0
0
25
267
0.93
0.08
1.0
1.1
—
—
—
0
0
303
2991
1.02
0.08
4.1
4.0
10.2
9.5
mg/mmol
0.06
197
1877
10
88
1.14
0.08
1.1
1.1
—
—
—
0
0
23
245
0.94
0.07
2.2
2.4
233.2
104.0
ug/min
0.29
13
145
22
208
1.06
0.05
2.1
2.5
—
—
—
0
0
15
160
0.94
0.04
1.1
1.1
—
—
—
0
0
15
159
0.94
0.03
1.0
1.1
—
—
—
0
0
13
122
1.07
0.02
7.8
2.2
32.5
32.7
pg
0.09
13
122
19
182
1.04
0.02
1.3
1.4
—
—
—
0
0
26
254
1.02
0.00
2.1
1.8
5.0
4.9
iu/l
0.01
12
84
17
166
1.02
0.00
1.4
1.4
123.0
106.6
u/ml
—
5
35
27
274
0.99
0.00
1.2
1.3
—
—
—
0
0
33
332
0.99
0.00
3.4
3.3
0.1
0.3
g/l
3.39
15
133
17
171
0.99
0.00
2.8
2.9
—
—
—
0
0
10
97
1.03
0.00
1.5
1.6
—
—
—
0
0
10
103
0.97
0.00
2.1
2.6
—
—
—
0
0
13
127
1.02
0.00
2.0
2.6
—
—
—
0
0
102
1023
1.00
0.00
1.9
1.7
—
—
—
0
0
57
575
0.99
0.00
1.4
1.4
—
—
—
0
0
26
255
1.02
0.00
6.7
4.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
8
87
0.92
0.00
1.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
33.7
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
8.8
—
—
—
0
0
0
7
0.00
0.00
0.0
4.6
—
—
—
0
0
0
7
0.00
0.00
0.0
5.0
—
—
—
0
0
5
51
0.98
0.00
1.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
0.1
—
0
5
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
5
54
0.93
0.00
1.0
1.1
—
1.6
—
0
14
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
9
95
0.95
0.00
2.3
2.4
—
—
—
0
0
5
55
0.91
0.00
1.2
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
330.6
—
0
5
7
72
0.97
0.00
1.6
1.4
—
70.4
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
5
54
0.93
0.00
1.2
1.5
1.1
1.1
nmol/l
—
5
40
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
63
0.95
0.00
2.7
4.0
—
—
—
0
0
5
56
0.89
0.00
1.0
1.6
—
11.7
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_OTHER_NOS and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_OTHER_NOS 1.242 [1.09, 1.41] < 0.001
Birth year 0.991 [0.98, 1.0] 0.039

During the follow-up period (1.1.1998 — 31.12.2019), 549 out of 2966 females with CD2_BENIGN_OTHER_NOS died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_OTHER_NOS 1.366 [1.18, 1.57] < 0.001
Birth year 0.985 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 531 out of 2412 males with CD2_BENIGN_OTHER_NOS died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_OTHER_NOS.

N-year risk Females Males
1 0.159% 0.289%
5 0.643% 1.611%
10 1.644% 3.828%
15 3.185% 6.966%
20 5.527% 11.602%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_OTHER_NOS – Benign neoplasm of other and unspecified sites

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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