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Benign neoplasm: Peripheral nerves and autonomic nervous system

DOID EFO Endpoint Browser PheWeb

CD2_BENIGN_PERIPH_AUTO_NEURO

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D36.1&
  • Hospital discharge: ICD-9 — 2258
  • Hospital discharge: ICD-8 — 225[5-6]
  • Cause of death: ICD-10 — D36.1&
  • Cause of death: ICD-9 — 2258
  • Cause of death: ICD-8 — 225[5-6]

2 out of 7 registries used, show all original rules.

590

4. Check minimum number of events

None

590

5. Include endpoints

None

590

6. Filter based on genotype QC (FinnGen only)

570

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D36
Name in latin
Neoplasma benignum nervi peripherici

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3668 2092 1552
Only index persons 3125 1824 1301
Unadjusted period prevalence (%)
Whole population 0.05 0.06 0.04
Only index persons 0.06 0.07 0.05
Median age at first event (years)
Whole population 48.92 49.76 47.77
Only index persons 47.22 48.14 45.92

-FinnGen-

Key figures

All Female Male
Number of individuals 570 326 244
Unadjusted period prevalence (%) 0.11 0.12 0.11
Median age at first event (years) 50.16 49.45 51.11

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
590
Matched controls
5900
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D36.1
ICD-10 Finland
Benign neoplasm: Peripheral nerves and autonomic nervous system
11638.4
307.7
422
*
22550
ICD-8 Finland
Benign neoplasm of brain and other parts of nervous system, Peripheral nerves
+∞
116.6
108
*
ACB19
NOMESCO Finland
Excision of lesion of peripheral nerve other or unspecified
148.3
63.3
66
5
2258X
ICD-9 Finland
Benign neoplasm of brain and other parts of nervous system, Other specified sites of nervous system
+∞
62.6
59
*
D48.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Connective and other soft tissue
9.3
37.1
46
53
NDR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of wrist or hand
12.5
31.0
31
26
D33.45
ICD-10 Finland
Benign Schwannom in the nerve root of the spinal cord
152.2
27.9
29
*
D48.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Peripheral nerves and autonomic nervous system
141.2
25.8
27
*
R22.4
ICD-10 Finland
Localized swelling, mass and lump, lower limb
7.1
25.4
39
58
Q85.00
ICD-10 Finland
Neurofibromatosis, type 1
+∞
24.1
23
*
Q85.09
ICD-10 Finland
Unspecified neurofibromatosis
+∞
23.1
22
*
N03AX16
ATC
[U] pregabalin
2.5
22.2
191
949
2401
FHL
Nerve exploration (includes biopsy and removal of local change)
47.7
19.3
23
5
R22.3
ICD-10 Finland
Localized swelling, mass and lump, upper limb
6.6
19.0
31
49
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
5.0
18.7
41
86
D48.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Neoplasm of uncertain or unknown behaviour, unspecified
6.1
17.1
30
51
R22.9
ICD-10 Finland
Localized swelling, mass and lump, unspecified
2.9
14.2
74
282
Q85.0
ICD-10 Finland
Neurofibromatosis (nonmalignant)
+∞
13.6
13
*
ABB00
NOMESCO Finland
Excision of lesion of spinal canal
+∞
13.6
13
*
R22.2
ICD-10 Finland
Localized swelling, mass and lump, trunk
4.4
13.5
34
80
D21.1
ICD-10 Finland
Benign neoplasm: Connective and other soft tissue of upper limb, including shoulder
13.4
13.0
22
17
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
4.1
12.9
36
92
9560/0-C72.9
ICD-O-3
Schwannoma, NOS, of nervous system, NOS
+∞
12.5
12
*
N03AX12
ATC
[U] gabapentin; oral
2.2
12.2
126
657
Z31.5
ICD-10 Finland
Genetic counselling
3.4
12.0
45
141
ACB99
NOMESCO Finland
Other operation for lesion of peripheral nerve: other or unspecified
47.7
11.9
14
*
D21.2
ICD-10 Finland
Benign neoplasm: Connective and other soft tissue of lower limb, including hip
25.6
11.2
15
6
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
3.6
10.9
36
104
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.5
10.6
69
294
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
9.0
10.3
21
24
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
10.3
169
1033
S04
ICPC
Lump/swelling localized
2.5
10.2
71
312
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
10.1
236
1607
Q85.01
ICD-10 Finland
Neurofibromatosis, type 2
+∞
9.4
9
*
SXC05
NOMESCO Finland
Other oral or dental procedure
2.9
9.1
44
161
D17.2
ICD-10 Finland
Benign lipomatous neoplasm of skin and subcutaneous tissue of limbs
4.2
9.1
24
59
D33.30
ICD-10 Finland
Acoustic neuroma
14.3
8.7
14
10
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
3.9
8.6
25
66
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
8.5
218
1506
ACB15
NOMESCO Finland
Excision of local lesion of tibial nerve
91.3
8.4
9
*
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
4.8
8.4
19
41
2312
FHL
Extirpation or destruction
+∞
8.3
8
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.4
8.1
58
258
NK1AT
NOMESCO Finland
Muscle biopsy with ultrasound guidance
22.4
8.0
11
5
ZXA05
NOMESCO Finland
Left side
1.8
7.9
157
1008
9273
FHL
Other surgery for toe deformity or pain condition, e.g., Morton, hammer toe
15.3
7.7
12
8
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
2.5
7.7
51
219
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.0
7.7
97
540
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.2
7.6
68
332
ACB18
NOMESCO Finland
Excision of local lesion of brachial plexus
+∞
7.3
7
*
XW3AT
NOMESCO Finland
Biopsy of other superficial organ with ultrasound guidance
12.2
7.1
12
10
WX110
NOMESCO Finland
Infiltration anesthesia
1.6
7.1
405
3370
N02BF01
ATC
gabapentin; oral
2.2
6.9
56
263
NFR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of hip or thigh
14.0
6.9
11
8
M01AH05
ATC
etoricoxib; oral
1.6
6.8
357
2896
D33.9
ICD-10 Finland
Benign neoplasm: Central nervous system, unspecified
40.5
6.8
8
*
D31.6
ICD-10 Finland
Benign neoplasm: Orbit, unspecified
22.8
6.7
9
*
R4120
NOMESCO Finland
Occupational therapy
2.4
6.7
45
195
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
3.7
6.5
20
55
S18
ICPC
Laceration/cut
1.6
6.4
266
2035
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.3
6.4
50
232
ABB10
NOMESCO Finland
Resection of lesion of spinal canal
+∞
6.3
6
*
ACB13
NOMESCO Finland
Excision of local lesion of ulnar nerve
+∞
6.3
6
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.8
6.2
95
562
SPAT1153
SPAT
Removal of sutures
1.6
6.1
183
1295

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
287
1940
1.93
13.68
2.3
2.1
—
—
—
0
0
92
419
2.42
12.29
1.3
1.4
—
—
—
0
0
120
627
2.15
11.53
1.4
1.3
—
—
—
0
0
295
2246
1.63
7.71
2.6
2.6
—
—
—
0
0
404
3456
1.54
5.43
4.1
3.8
—
—
—
0
0
278
2206
1.49
5.36
6.4
6.1
1.21
1.21
mmol/l
0.56
258
2002
301
2453
1.46
4.93
5.4
5.7
0.04
0.04
e9/l
0.17
258
2142
340
2838
1.47
4.91
8.2
9.2
3.99
4.07
e9/l
0.31
293
2496
541
5022
1.93
4.75
18.1
16.3
139.75
139.66
mmol/l
0.34
531
4890
87
542
1.71
4.73
8.1
9.1
1.44
1.22
mmol/l
0.21
65
435
299
2446
1.45
4.73
5.4
5.7
0.56
0.58
e9/l
0.88
256
2130
542
5036
1.94
4.72
18.0
16.4
3.95
3.97
mmol/l
1.67
530
4896
306
2522
1.44
4.60
5.5
6.0
0.19
0.19
e9/l
0.34
267
2226
414
3623
1.48
4.46
4.0
4.2
10.38
12.15
mm/h
2.09
379
3338
278
2267
1.43
4.35
12.8
13.6
1.27
1.23
inr
0.28
71
675
525
4856
1.74
4.29
15.3
14.2
23.00
23.57
mg/l
0.14
417
3859
194
1489
1.45
4.18
2.3
2.1
148.17
187.01
u/l
1.04
183
1412
302
2514
1.41
4.13
5.4
5.8
1.85
1.93
e9/l
0.60
263
2241
15
47
3.25
4.08
1.7
1.7
—
—
—
0
0
290
2401
1.41
4.07
6.7
7.0
1.21
1.22
mmol/l
0.72
256
2049
162
1216
1.46
3.88
5.8
6.7
—
—
—
0
0
206
1624
1.41
3.76
3.4
3.5
2.36
2.36
mmol/l
0.01
182
1424
48
269
1.85
3.74
2.8
3.5
4.19
4.61
pmol/l
1.88
42
237
192
1512
1.40
3.48
2.4
2.4
—
—
—
0
0
331
2850
1.37
3.45
5.6
5.0
6.64
6.73
mmol/l
0.28
319
2679
15
53
2.88
3.38
1.9
1.3
0.16
0.31
nmol/l
—
9
41
416
3723
1.40
3.37
4.2
3.9
14.55
14.82
pmol/l
1.46
379
3365
275
2307
1.36
3.35
6.3
6.2
—
—
—
0
0
15
54
2.82
3.27
2.3
1.3
—
—
nmol/l
—
0
0
150
1153
1.40
3.09
2.3
2.3
—
—
—
0
0
276
2339
1.34
3.05
5.6
5.8
56.15
57.34
%
0.93
259
2197
15
58
2.63
2.89
2.3
1.3
—
—
—
0
0
50
310
1.67
2.81
8.4
6.1
—
—
—
0
0
114
850
1.42
2.77
1.3
1.3
34.32
38.48
iu/ml
0.11
35
286
481
4466
1.42
2.74
5.1
4.7
1.91
2.19
mu/l
0.51
434
4074
54
344
1.63
2.74
2.8
2.6
13.66
19.33
au/ml
—
8
23
271
2318
1.31
2.71
6.1
6.2
8.48
8.57
%
0.15
254
2171
33
183
1.85
2.71
9.4
4.5
—
—
—
0
0
244
2058
1.32
2.70
4.6
4.7
35.34
35.63
g/l
0.32
223
1923
184
1493
1.34
2.66
3.8
3.8
7.40
7.40
ph
0.05
23
287
269
2308
1.30
2.60
5.6
5.9
2.95
2.80
%
0.48
252
2157
119
905
1.39
2.58
1.8
1.7
1117.75
1198.31
nmol/l
0.47
87
676
98
721
1.43
2.56
1.9
2.1
—
—
—
0
0
15
62
2.46
2.56
2.3
1.3
0.47
0.54
nmol/l
0.60
15
55
275
2374
1.30
2.51
5.9
6.0
28.37
27.70
%
0.43
258
2226
296
2591
1.29
2.39
6.1
6.2
10.92
11.33
umol/l
0.30
280
2462
57
384
1.54
2.31
5.8
9.1
—
—
—
0
0
107
818
1.38
2.25
1.4
1.3
5.84
14.42
u/ml
0.94
38
325
31
180
1.76
2.23
1.5
1.3
29.89
24.90
iu/l
0.28
21
159
84
617
1.42
2.23
3.7
5.3
1.04
1.02
mmol/l
0.30
78
565
40
252
1.63
2.16
7.1
11.2
24.54
24.55
mmol/l
0.00
40
247
235
2027
1.26
2.05
2.8
2.7
124.03
123.65
ug/l
0.01
214
1861
12
50
2.43
2.03
3.9
3.1
1.97
6.74
nmol/l
0.85
12
50
367
3338
1.26
2.02
4.7
4.3
—
—
—
0
0
47
314
1.54
2.00
1.2
1.2
—
—
—
0
0
255
2230
1.25
1.95
5.6
5.9
0.69
0.68
%
0.12
239
2078
59
417
1.46
1.93
2.2
2.5
5.34
7.49
ug/l
0.52
51
368
39
252
1.59
1.92
2.4
2.4
—
—
—
0
0
231
2005
1.25
1.87
2.1
2.3
76.78
77.10
nmol/l
0.06
202
1782
541
5207
1.47
1.83
11.1
10.4
25.17
26.38
u/l
1.26
524
5024
7
23
3.07
1.80
1.3
1.2
160.57
183.20
mmol/24h
—
7
23
77
580
1.38
1.79
1.2
1.3
—
—
—
0
0
11
47
2.37
1.78
1.0
1.4
—
—
—
0
0
113
906
1.31
1.74
4.5
3.8
133.89
196.94
ng/l
0.34
90
717
98
771
1.33
1.72
4.0
3.6
0.82
0.81
mmol/l
0.09
91
723
55
394
1.44
1.70
3.5
3.3
—
—
—
0
0
134
1102
1.28
1.70
4.0
3.6
—
—
—
0
0
153
1280
1.26
1.68
1.4
1.4
—
—
—
0
0
52
370
1.44
1.67
2.1
3.6
70.84
79.36
ng/l
0.51
45
327
93
730
1.33
1.66
2.0
2.1
29.25
29.68
s
0.32
93
714
90
706
1.32
1.62
1.2
1.2
—
—
—
0
0
527
5068
1.37
1.60
15.0
13.2
—
—
—
0
0
349
3201
1.22
1.60
4.9
4.5
985.40
2304.41
e6/l
—
5
54
176
1507
1.24
1.57
3.1
3.1
—
—
—
0
0
24
146
1.67
1.53
2.3
3.3
—
—
—
0
0
153
1786
0.81
1.50
2.5
2.8
—
—
—
0
0
131
1091
1.26
1.49
1.3
1.3
1.50
1.33
u/ml
0.11
29
302
52
379
1.41
1.49
1.2
1.2
—
—
—
0
0
267
2397
1.21
1.48
4.7
4.9
0.00
0.00
estimate
0.50
50
453
153
1299
1.24
1.47
4.8
4.0
0.00
0.00
estimate
0.50
49
446
60
451
1.37
1.44
2.6
2.4
33.04
34.06
u/l
0.07
45
387
556
5410
1.48
1.43
24.1
20.9
40.59
40.29
%
0.76
522
5101
556
5411
1.48
1.41
23.9
20.7
252.28
249.60
e9/l
0.45
546
5278
67
514
1.34
1.41
4.2
4.0
3.68
34.25
ug/l
1.20
49
424
556
5413
1.47
1.39
23.9
20.6
30.13
30.32
pg
2.04
549
5337
556
5414
1.47
1.37
23.9
20.7
6.45
6.65
e9/l
1.74
544
5265
556
5414
1.47
1.37
23.9
20.6
90.57
91.07
fl
2.20
549
5338
556
5414
1.47
1.37
24.0
20.7
4.51
4.50
e12/l
0.25
544
5267
0
38
0.00
1.34
0.0
1.2
—
—
—
0
0
265
2394
1.19
1.34
3.9
3.7
0.00
0.00
estimate
0.50
49
488
36
250
1.47
1.34
9.3
12.4
—
—
—
0
0
10
47
2.15
1.34
4.8
2.1
13.66
13.07
%
—
10
47
556
5417
1.46
1.34
24.1
20.8
135.48
135.63
g/l
0.09
550
5338
404
3793
1.21
1.32
8.2
7.5
74.17
78.90
u/l
1.24
385
3560
216
1919
1.20
1.31
3.5
3.3
6.21
5.84
ph
0.74
14
151
6
24
2.51
1.30
1.7
1.9
—
—
—
0
0
14
243
0.57
1.30
3.4
3.4
—
—
—
0
0
58
444
1.34
1.26
2.6
1.8
355.36
378.00
nmol/l
0.37
53
412
10
49
2.06
1.22
1.4
1.2
—
—
—
0
0
30
206
1.48
1.20
1.0
1.1
—
—
—
0
0
220
1972
1.18
1.19
2.1
2.0
97.50
95.60
pmol/l
0.26
108
1001
6
26
2.32
1.19
1.2
1.2
—
—
—
0
0
6
130
0.46
1.17
2.0
4.3
—
—
—
0
0
212
1897
1.18
1.17
3.5
3.7
20.91
32.94
ng/l
2.58
135
1331
0
34
0.00
1.16
0.0
1.3
—
1.82
—
0
34
8
153
0.52
1.15
1.8
1.5
—
—
—
0
0
151
1312
1.20
1.15
2.9
3.0
—
—
—
0
0
266
2428
1.17
1.15
3.9
3.7
0.00
0.01
estimate
0.80
48
435
135
1162
1.21
1.14
2.7
2.1
2.80
3.06
mg/l
0.83
116
995
26
176
1.50
1.12
10.3
4.3
1.19
1.40
mmol/l
1.03
26
171
5
21
2.39
1.09
1.0
1.0
—
—
—
0
0
346
3234
1.17
1.09
2.9
3.1
39.89
49.84
u/l
2.21
319
3011
6
123
0.48
1.06
2.2
1.5
—
—
—
0
0
29
204
1.44
1.05
1.3
1.2
—
—
—
0
0
473
4548
1.20
1.01
5.5
5.8
39.04
40.01
mmol/mol
1.79
431
4233
7
35
2.01
1.00
1.1
1.8
37.31
35.40
%
—
7
35
48
372
1.32
0.99
3.4
3.2
130.60
173.95
ng/l
0.65
42
340
146
1282
1.18
0.99
2.1
2.6
2606.37
6834.43
umol/l
0.93
132
1127
176
1573
1.17
0.97
2.9
2.5
68.87
62.45
u/l
0.21
163
1443
72
591
1.25
0.96
1.8
2.2
90.08
135.88
ug/g
1.06
56
459
494
4776
1.21
0.95
4.6
4.6
5.96
5.98
mmol/l
0.09
448
4362
9
51
1.78
0.95
2.0
3.1
—
—
—
0
0
126
1101
1.18
0.91
1.9
1.7
0.92
1.21
mg/l
0.83
102
846
9
155
0.57
0.89
1.8
1.5
—
—
—
0
0
9
155
0.57
0.89
1.8
1.4
—
—
—
0
0
9
156
0.57
0.89
1.8
1.5
—
—
—
0
0
17
111
1.55
0.88
3.1
1.8
179.88
226.38
pmol/l
1.28
17
105
8
43
1.87
0.87
1.1
1.4
—
—
—
0
0
11
64
1.73
0.86
1.1
1.1
0.54
3.22
u/ml
—
5
36
149
1326
1.17
0.86
4.0
4.2
—
—
—
0
0
8
45
1.79
0.84
1.0
1.1
—
—
—
0
0
16
105
1.54
0.82
1.9
2.5
—
—
—
0
0
86
733
1.20
0.82
2.2
2.3
15.04
13.13
umol/l
1.44
76
683
131
1161
1.16
0.80
1.5
1.5
20.98
20.90
nmol/l
0.02
106
981
15
98
1.54
0.79
4.0
2.8
—
—
—
0
0
508
4947
1.19
0.77
5.0
4.9
2.81
2.76
mmol/l
0.65
459
4551
6
34
1.77
0.76
1.3
1.4
0.89
1.03
g/l
—
6
34
79
674
1.20
0.76
1.3
1.3
630.77
535.32
titre
0.09
13
154
116
1024
1.17
0.75
2.6
2.5
7.65
5.30
e6/l
0.91
100
934
9
54
1.68
0.75
1.8
2.4
—
—
—
0
0
5
24
2.09
0.74
1.0
1.1
—
—
—
0
0
189
1731
1.14
0.73
3.4
3.7
31.11
120.62
e6/l
2.74
136
1239
149
1343
1.15
0.73
3.1
3.1
0.69
0.47
e6/l
0.44
119
1020
103
904
1.17
0.72
3.5
2.9
2.46
2.45
mmol/l
0.23
88
792
498
4848
1.17
0.72
4.4
4.5
4.75
4.67
mmol/l
0.94
456
4486
59
492
1.22
0.72
1.6
1.5
—
—
—
0
0
165
1500
1.14
0.71
5.1
4.7
2.32
2.43
ug/l
0.11
153
1344
7
40
1.76
0.71
1.0
1.1
—
—
—
0
0
39
310
1.28
0.71
1.3
1.7
2.13
1.44
g/l
0.53
30
286
9
144
0.62
0.70
1.8
1.5
—
—
—
0
0
14
93
1.52
0.70
1.0
1.3
—
—
—
0
0
7
42
1.67
0.68
1.0
1.2
—
—
—
0
0
65
551
1.20
0.68
1.4
1.7
—
—
—
0
0
7
43
1.64
0.67
1.0
1.0
—
2.00
—
0
17
5
28
1.79
0.66
1.4
1.3
—
—
—
0
0
12
79
1.53
0.63
1.3
1.4
—
—
—
0
0
6
102
0.58
0.62
2.8
1.8
—
—
—
0
0
176
1621
1.12
0.62
3.6
3.3
33.77
31.60
u/l
0.17
165
1539
0
20
0.00
0.60
0.0
2.4
—
53.62
—
0
13
12
80
1.51
0.60
1.5
1.4
—
—
—
0
0
45
378
1.21
0.54
2.2
2.6
9.94
10.64
g/l
0.78
40
345
232
2186
1.10
0.53
8.7
9.4
0.00
0.00
e9/l
0.54
186
1808
41
342
1.21
0.53
2.7
2.6
—
—
—
0
0
7
45
1.56
0.49
1.4
1.3
—
—
—
0
0
37
439
0.83
0.47
1.3
1.4
—
—
—
0
0
107
974
1.12
0.47
1.3
1.4
2.19
2.48
g/l
0.90
56
596
26
319
0.81
0.46
3.1
2.8
—
—
—
0
0
60
528
1.15
0.44
2.0
2.6
1.68
1.82
%
0.88
50
476
13
95
1.38
0.44
1.6
1.5
—
—
—
0
0
20
157
1.28
0.44
1.0
1.2
—
—
—
0
0
5
31
1.62
0.43
6.0
1.9
—
—
—
0
0
5
31
1.62
0.43
2.0
2.4
—
—
—
0
0
71
634
1.14
0.43
2.3
2.3
25.86
22.49
%
1.06
57
543
15
113
1.34
0.43
1.1
1.2
3.81
3.81
mmol/l
0.00
15
103
6
91
0.66
0.42
1.3
1.6
—
—
—
0
0
64
568
1.14
0.42
2.5
2.7
9.59
8.87
umol/l
0.08
57
496
154
1438
1.10
0.42
3.5
3.9
—
—
—
0
0
5
32
1.57
0.42
1.2
1.5
—
—
—
0
0
116
1069
1.11
0.41
4.7
3.9
1.02
1.02
kg/l
0.62
11
151
0
16
0.00
0.41
0.0
1.7
—
—
—
0
0
17
132
1.30
0.40
1.1
1.3
—
—
—
0
0
110
1013
1.11
0.40
1.6
1.7
456.25
13111278.68
pmol/l
0.80
91
839
12
88
1.37
0.40
1.3
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
2.3
—
—
—
0
0
7
101
0.69
0.40
1.0
1.2
—
—
—
0
0
151
1414
1.09
0.39
2.8
3.2
711.18
1121.31
ng/l
1.99
124
1192
5
35
1.43
0.39
1.2
1.1
35.80
44.10
mg/l
—
5
29
11
148
0.74
0.39
1.1
2.2
11.48
12.13
mg/l
0.16
11
135
5
36
1.39
0.38
1.2
1.7
1.97
1.12
e9/l
—
5
31
9
67
1.35
0.38
1.2
1.1
—
—
—
0
0
46
406
1.14
0.34
2.6
2.9
66.95
67.08
g/l
0.04
41
360
6
44
1.37
0.34
1.0
1.4
5.88
6.55
g/l
—
6
33
6
44
1.37
0.34
1.0
1.4
0.23
0.31
g/l
—
6
32
12
91
1.33
0.34
1.2
1.4
—
—
—
0
0
6
45
1.34
0.34
2.0
1.8
—
—
—
0
0
6
46
1.31
0.33
1.0
1.1
—
—
—
0
0
26
306
0.84
0.33
1.2
1.2
177.18
107.58
iu/ml
0.44
13
126
24
284
0.84
0.32
1.4
1.5
—
—
—
0
0
14
176
0.79
0.32
1.3
1.3
1.12
1.18
g/l
0.33
14
167
141
1329
1.08
0.32
1.7
1.6
1.27
1.39
mmol/l
1.32
123
1109
47
418
1.14
0.32
5.4
3.9
—
—
—
0
0
15
186
0.80
0.31
1.0
1.1
—
—
—
0
0
7
54
1.30
0.30
1.0
1.1
—
—
—
0
0
83
767
1.10
0.30
2.6
2.9
3.04
2.29
e6/l
0.30
46
418
14
113
1.24
0.27
1.6
1.8
—
—
—
0
0
150
1428
1.07
0.27
3.0
3.2
936.73
317.02
mg/l
0.47
100
907
18
150
1.21
0.26
1.6
1.4
248.00
318.56
ug/g
0.76
12
85
47
425
1.12
0.26
5.3
4.1
0.67
0.90
%
0.63
21
157
73
676
1.09
0.26
2.2
2.3
2.38
2.35
g/l
0.12
66
627
51
464
1.11
0.25
1.3
1.4
—
—
—
0
0
94
882
1.08
0.25
3.4
2.9
0.74
0.74
ug/l
0.03
69
559
43
388
1.12
0.25
2.0
2.9
60.51
72.13
e9/l
2.84
31
292
20
170
1.18
0.25
6.7
10.2
—
—
—
0
0
24
208
1.16
0.24
1.9
1.9
—
—
—
0
0
15
124
1.22
0.24
1.1
1.3
544.73
457.21
mg/l
0.70
15
113
472
4657
1.07
0.24
4.0
4.0
1.24
1.29
mmol/l
1.00
437
4265
16
190
0.84
0.23
2.1
2.8
—
—
—
0
0
16
134
1.20
0.23
1.0
1.2
—
—
—
0
0
37
410
0.90
0.23
3.8
3.9
1.23
1.23
mmol/l
0.13
27
362
488
4822
1.07
0.23
4.5
4.4
1.52
1.47
mmol/l
1.59
447
4435
11
88
1.25
0.22
1.0
1.6
—
—
—
0
0
7
91
0.77
0.22
1.1
2.7
—
—
—
0
0
5
40
1.25
0.22
1.0
1.3
—
—
—
0
0
26
229
1.14
0.22
2.1
2.2
1.39
1.20
%
0.24
26
229
49
533
0.91
0.22
1.6
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
4.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
32
287
1.12
0.21
1.1
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
6
52
1.16
0.19
1.2
1.1
—
—
—
0
0
41
377
1.09
0.18
4.6
4.1
0.38
0.52
%
0.28
13
127
51
475
1.08
0.17
3.7
4.3
—
—
—
0
0
7
63
1.11
0.17
1.6
1.4
41.44
31.83
g/l
—
7
54
8
72
1.11
0.16
1.8
1.3
—
—
—
0
0
20
224
0.89
0.15
3.0
3.2
25.48
25.24
mmol/l
0.19
20
219
6
79
0.76
0.15
1.0
1.1
—
—
—
0
0
6
79
0.76
0.15
1.0
1.1
—
—
—
0
0
156
1514
1.04
0.15
3.0
3.1
7.70
7.52
mmol/l
0.20
134
1269
31
286
1.09
0.13
2.6
3.1
131.00
126.71
g/l
0.73
31
281
21
232
0.90
0.13
7.5
3.8
—
—
—
0
0
49
516
0.95
0.11
1.8
1.6
—
—
—
0
0
20
219
0.91
0.11
1.8
1.8
—
—
—
0
0
10
86
1.17
0.11
3.3
1.6
—
—
—
0
0
5
44
1.14
0.10
1.0
1.4
2.43
2.63
g/l
—
5
32
154
1507
1.03
0.09
3.5
3.8
5.08
9.03
mg/mmol
0.78
102
938
5
46
1.09
0.09
1.0
1.4
—
—
—
0
0
15
165
0.91
0.09
1.3
1.3
0.22
0.24
g/l
0.29
15
157
6
58
1.03
0.08
1.3
1.4
—
—
—
0
0
6
58
1.03
0.08
1.3
1.4
—
—
—
0
0
58
601
0.96
0.08
1.5
1.4
—
—
—
0
0
75
772
0.97
0.07
1.6
1.8
—
—
—
0
0
9
84
1.07
0.07
2.7
3.1
3.49
4.33
e9/l
—
9
84
10
89
1.13
0.07
3.1
3.4
55.20
58.28
%
—
10
89
13
142
0.91
0.06
1.0
1.1
—
—
—
0
0
16
148
1.08
0.06
1.3
1.3
—
—
—
0
0
150
1478
1.02
0.05
3.1
3.2
17.19
113.94
e6/l
1.46
116
1155
36
346
1.04
0.05
1.6
1.5
—
—
—
0
0
62
636
0.97
0.05
1.5
1.6
—
—
—
0
0
32
307
1.04
0.05
6.4
3.7
7.41
7.41
ph
—
6
37
38
367
1.04
0.04
4.9
4.3
0.00
0.11
%
0.74
11
100
35
361
0.97
0.03
1.6
1.5
—
—
—
0
0
132
1332
0.99
0.02
3.3
3.3
—
—
—
0
0
13
137
0.95
0.01
1.9
2.5
362.06
66.84
ug/min
—
7
83
17
174
0.98
0.00
1.7
1.6
—
—
—
0
0
36
356
1.01
0.00
1.4
1.7
—
—
—
0
0
40
396
1.01
0.00
5.1
4.2
0.07
0.11
%
0.20
14
128
13
128
1.02
0.00
1.8
1.6
14209.13
16666.93
e6/l
—
8
94
12
121
0.99
0.00
3.1
4.3
—
—
—
0
0
34
341
1.00
0.00
2.9
2.8
3.54
4.89
e9/l
1.07
28
280
99
989
1.00
0.00
2.5
2.8
522.90
544.34
mosm/kgh2o
0.54
81
855
7
69
1.01
-0.00
3.7
6.2
361.71
373.73
umol/l
—
7
62
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
59
0.85
-0.00
2.2
2.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
17.87
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
6
61
0.98
-0.00
1.3
1.5
—
—
—
0
0
12
120
1.00
-0.00
3.8
2.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
9
91
0.99
-0.00
1.0
1.1
—
—
—
0
0
6
64
0.94
-0.00
1.2
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
8
82
0.98
-0.00
4.1
2.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
16.79
—
0
8
0
8
0.00
-0.00
0.0
2.3
—
2318.50
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
77
0.91
-0.00
2.6
3.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
2.37
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
52
0.96
-0.00
2.2
2.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
180.40
—
0
5
5
56
0.89
-0.00
1.2
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
4.2
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_PERIPH_AUTO_NEURO and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_PERIPH_AUTO_NEURO 1.074 [0.83, 1.39] 0.589
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 883 females with CD2_BENIGN_PERIPH_AUTO_NEURO died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_PERIPH_AUTO_NEURO 1.103 [0.85, 1.43] 0.46
Birth year 0.985 [0.97, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 80 out of 763 males with CD2_BENIGN_PERIPH_AUTO_NEURO died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_PERIPH_AUTO_NEURO.

N-year risk Females Males
1 0.081% 0.203%
5 0.509% 1.092%
10 1.267% 2.805%
15 2.412% 5.409%
20 3.959% 9.269%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_PERIPH_AUTO_NEURO – Benign neoplasm: Peripheral nerves and autonomic nervous system

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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