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Benign neoplasm: Peripheral nerves and autonomic nervous system

DOID EFO Endpoint Browser PheWeb

CD2_BENIGN_PERIPH_AUTO_NEURO

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D36.1&
  • Hospital discharge: ICD-9 — 2258
  • Hospital discharge: ICD-8 — 225[5-6]
  • Cause of death: ICD-10 — D36.1&
  • Cause of death: ICD-9 — 2258
  • Cause of death: ICD-8 — 225[5-6]

2 out of 7 registries used, show all original rules.

546

4. Check minimum number of events

None

546

5. Include endpoints

None

546

6. Filter based on genotype QC (FinnGen only)

546

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D36
Name in latin
Neoplasma benignum nervi peripherici

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3668 2092 1552
Only index persons 3125 1824 1301
Unadjusted period prevalence (%)
Whole population 0.05 0.06 0.04
Only index persons 0.06 0.07 0.05
Median age at first event (years)
Whole population 48.92 49.76 47.77
Only index persons 47.22 48.14 45.92

-FinnGen-

Key figures

All Female Male
Number of individuals 546 311 235
Unadjusted period prevalence (%) 0.10 0.11 0.10
Median age at first event (years) 49.09 48.00 50.55

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
487
Matched controls
4869
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D36.1
ICD-10 Finland
Benign neoplasm: Peripheral nerves and autonomic nervous system
+∞
323.0
337
*
22550
ICD-8 Finland
Benign neoplasm of brain and other parts of nervous system, Peripheral nerves
+∞
105.1
97
*
ACB19
NOMESCO Finland
Excision of lesion of peripheral nerve other or unspecified
+∞
60.7
57
*
2258X
ICD-9 Finland
Benign neoplasm of brain and other parts of nervous system, Other specified sites of nervous system
+∞
56.4
53
*
Q85.00
ICD-10 Finland
Neurofibromatosis, type 1
219.0
20.7
21
*
D33.45
ICD-10 Finland
Benign Schwannom in the nerve root of the spinal cord
76.8
19.9
22
*
D48.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Peripheral nerves and autonomic nervous system
+∞
18.9
18
*
Q85.09
ICD-10 Finland
Unspecified neurofibromatosis
104.1
18.7
20
*
2401
FHL
Nerve exploration (includes biopsy and removal of local change)
104.1
18.7
20
*
D48.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Connective and other soft tissue
9.2
17.3
36
42
N03AX16
ATC
pregabalin; oral
2.6
17.1
154
736
NDR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of wrist or hand
14.6
15.2
25
18
N03AX12
ATC
gabapentin; oral
2.8
14.0
101
419
9560/0-C72.9
ICD-O-3
Schwannoma, NOS, of nervous system, NOS
+∞
12.6
12
*
ACB99
NOMESCO Finland
Other operation for lesion of peripheral nerve: other or unspecified
133.3
12.5
13
*
ABB00
NOMESCO Finland
Excision of lesion of spinal canal
133.3
12.5
13
*
Q85.0
ICD-10 Finland
Neurofibromatosis (nonmalignant)
133.3
12.5
13
*
R22.4
ICD-10 Finland
Localized swelling, mass and lump, lower limb
6.6
11.6
29
46
D21.1
ICD-10 Finland
Benign neoplasm: Connective and other soft tissue of upper limb, including shoulder
15.5
11.4
18
12
D48.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Neoplasm of uncertain or unknown behaviour, unspecified
8.4
11.2
24
30
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
5.4
11.1
33
65
D21.2
ICD-10 Finland
Benign neoplasm: Connective and other soft tissue of lower limb, including hip
20.5
9.9
14
7
R22.3
ICD-10 Finland
Localized swelling, mass and lump, upper limb
7.0
9.7
23
34
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
8.8
143
858
D33.30
ICD-10 Finland
Acoustic neuroma
16.6
8.6
13
8
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.9
8.5
53
199
D17.2
ICD-10 Finland
Benign lipomatous neoplasm of skin and subcutaneous tissue of limbs
6.4
8.4
21
34
Q85.01
ICD-10 Finland
Neurofibromatosis, type 2
+∞
8.4
8
*
D33.9
ICD-10 Finland
Benign neoplasm: Central nervous system, unspecified
+∞
8.4
8
*
Z31.5
ICD-10 Finland
Genetic counselling
3.9
8.2
33
90
ZXA05
NOMESCO Finland
Left side
1.9
8.2
134
799
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
4.5
8.0
27
63
NFR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of hip or thigh
45.7
7.7
9
*
NK1AT
NOMESCO Finland
Muscle biopsy with ultrasound guidance
18.7
7.6
11
6
WX110
NOMESCO Finland
Local anesthesy
1.7
7.5
324
2607
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
3.6
7.5
32
93
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.5
7.4
60
263
ACB18
NOMESCO Finland
Excision of local lesion of brachial plexus
+∞
7.3
7
*
ACB15
NOMESCO Finland
Excision of local lesion of tibial nerve
+∞
7.3
7
*
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.2
6.6
71
354
2312
FHL
Extirpation or destruction
70.7
6.4
7
*
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
6.7
6.4
15
23
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.5
6.3
48
205
M01AH05
ATC
etoricoxib; oral
1.6
6.3
275
2167
D33.4
ICD-10 Finland
Benign neoplasm: Spinal cord
+∞
6.3
6
*
74340
ICD-8 Finland
Other congenital anomalies of nervous system, Neurofibromatosis
+∞
6.3
6
*
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
5.2
6.2
18
36
R22.9
ICD-10 Finland
Localized swelling, mass and lump, unspecified
2.6
6.1
43
176
ACC19
NOMESCO Finland
Transcision of peripheral nerve: other or unspecified
10.2
6.1
11
11
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.5
6.0
45
188

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
268
1799
1.96
13.26
2.3
2.1
—
—
—
0
0
88
390
2.50
12.56
1.3
1.4
—
—
—
0
0
114
581
2.22
11.78
1.4
1.3
—
—
—
0
0
272
2064
1.63
7.28
4.0
4.1
—
—
—
0
0
234
1813
1.51
5.15
6.5
8.7
1.2
1.2
inr
0.06
56
541
384
3332
1.51
4.62
4.0
4.2
10.5
12.2
mm/h
1.71
350
3065
370
3190
1.50
4.55
4.0
3.8
—
—
—
0
0
499
4634
1.89
4.31
18.4
16.3
139.8
139.7
mmol/l
0.66
489
4511
500
4648
1.90
4.27
18.3
16.4
3.9
4.0
mmol/l
1.59
488
4518
310
2608
1.44
4.15
8.3
9.2
4.0
4.1
e9/l
0.42
266
2300
485
4477
1.75
4.12
15.7
14.2
23.4
23.7
mg/l
0.07
387
3547
251
2034
1.43
4.12
6.6
6.1
1.2
1.2
mmol/l
0.56
230
1840
180
1375
1.46
4.03
2.2
2.1
151.7
191.6
u/l
0.96
169
1302
273
2253
1.42
4.01
5.6
5.8
0.0
0.0
e9/l
0.20
233
1973
79
511
1.64
3.75
8.5
9.2
1.3
1.3
mmol/l
0.02
56
407
191
1492
1.43
3.75
3.3
3.4
2.4
2.4
mmol/l
0.08
166
1304
269
2240
1.40
3.63
5.6
5.8
0.6
0.6
e9/l
0.69
229
1956
179
1389
1.43
3.62
2.4
2.4
—
—
—
0
0
277
2320
1.39
3.60
5.7
6.0
0.2
0.2
e9/l
0.16
241
2054
149
1121
1.45
3.55
5.7
6.5
—
—
—
0
0
48
277
1.80
3.43
1.3
1.4
—
42.2
—
0
17
266
2226
1.38
3.41
6.8
6.9
1.2
1.2
mmol/l
0.66
231
1886
140
1052
1.44
3.34
2.3
2.4
—
—
—
0
0
13
43
3.07
3.27
1.8
1.7
—
—
—
0
0
305
2623
1.37
3.24
5.7
5.0
6.7
6.8
mmol/l
0.13
293
2463
272
2303
1.36
3.16
5.7
5.8
1.9
1.9
e9/l
0.57
236
2045
382
3418
1.39
3.10
4.2
3.9
14.5
14.8
pmol/l
1.62
347
3088
446
4102
1.48
3.10
5.0
4.7
1.9
2.2
mu/l
0.49
400
3736
50
310
1.67
2.82
2.7
2.5
11.8
15.8
au/ml
—
5
13
13
49
2.69
2.64
1.2
1.3
—
—
nmol/l
—
0
0
42
254
1.71
2.61
2.3
3.5
4.1
4.5
pmol/l
2.19
36
222
275
2385
1.31
2.50
6.2
6.2
10.9
11.5
umol/l
0.38
260
2264
91
667
1.44
2.45
2.0
2.1
—
—
—
0
0
13
52
2.54
2.37
1.2
1.3
—
—
—
0
0
224
1901
1.30
2.35
4.6
4.7
35.0
35.6
g/l
0.76
203
1776
249
2144
1.30
2.34
5.9
5.8
56.4
57.4
%
0.65
233
2016
54
359
1.56
2.33
6.1
9.1
—
—
—
0
0
99
753
1.38
2.17
1.4
1.3
6.5
13.8
u/ml
0.64
33
300
340
3067
1.29
2.16
4.8
4.3
—
—
—
0
0
45
293
1.58
2.14
8.6
6.2
—
—
—
0
0
12
49
2.48
2.11
1.9
1.3
0.1
0.3
nmol/l
—
6
37
13
56
2.35
2.06
1.2
1.3
0.5
0.5
nmol/l
0.57
13
49
107
833
1.35
2.03
4.4
3.8
123.8
199.4
ng/l
0.40
84
660
11
44
2.53
2.02
3.4
3.1
2.0
7.3
nmol/l
0.82
11
44
77
568
1.41
2.02
3.7
5.2
1.0
1.0
mmol/l
0.50
71
520
244
2125
1.27
2.01
6.4
6.2
8.5
8.6
%
0.12
228
1996
85
639
1.39
2.00
1.2
1.2
—
—
—
0
0
28
165
1.73
1.95
1.4
1.3
31.8
25.6
iu/l
0.31
18
146
248
2171
1.26
1.94
6.1
6.0
28.4
27.6
%
0.51
232
2029
29
173
1.71
1.93
9.6
4.6
—
—
—
0
0
106
831
1.34
1.92
1.9
1.7
1046.9
1189.8
nmol/l
0.99
75
625
101
786
1.35
1.92
1.3
1.3
32.8
35.5
iu/ml
0.06
33
255
165
1376
1.29
1.92
3.9
3.8
7.4
7.4
ph
0.04
22
264
126
1014
1.32
1.91
5.0
4.7
—
—
—
0
0
37
237
1.60
1.90
2.4
2.4
—
—
—
0
0
242
2117
1.26
1.89
5.8
5.9
2.9
2.8
%
0.31
226
1972
43
286
1.55
1.89
1.3
1.2
—
—
—
0
0
23
130
1.80
1.84
2.3
3.4
—
—
—
0
0
87
666
1.36
1.84
1.9
2.1
29.1
29.7
s
0.54
87
653
92
712
1.35
1.82
3.9
3.4
0.8
0.8
mmol/l
0.08
86
667
10
41
2.47
1.76
1.0
1.4
—
—
—
0
0
175
1486
1.26
1.74
5.8
5.8
—
—
—
0
0
488
4675
1.41
1.72
15.0
13.3
—
—
—
0
0
140
1171
1.26
1.56
1.3
1.4
—
—
—
0
0
498
4801
1.42
1.55
11.2
10.3
25.1
26.5
u/l
1.45
481
4631
10
44
2.30
1.54
4.8
2.1
13.7
13.1
%
—
10
44
231
2048
1.22
1.51
5.8
5.9
0.7
0.7
%
0.15
215
1913
514
4991
1.51
1.47
23.9
20.7
252.1
249.1
e9/l
0.47
504
4866
141
1653
0.80
1.47
2.6
2.8
—
—
—
0
0
514
4993
1.50
1.44
23.9
20.6
30.2
30.3
pg
1.73
507
4922
143
1211
1.25
1.43
3.0
3.0
—
—
—
0
0
514
4994
1.50
1.42
24.0
20.6
90.6
91.1
fl
2.00
507
4923
514
4994
1.50
1.42
24.1
20.7
4.5
4.5
e12/l
0.28
502
4856
514
4995
1.50
1.41
24.1
20.8
6.5
6.7
e9/l
1.54
502
4855
514
4997
1.49
1.38
24.2
20.8
135.7
135.7
g/l
0.01
508
4923
6
23
2.63
1.37
1.2
1.2
—
—
—
0
0
6
23
2.63
1.37
1.7
1.9
—
—
—
0
0
374
3497
1.22
1.37
8.4
7.5
73.9
78.6
u/l
1.15
354
3278
0
37
0.00
1.35
0.0
1.2
—
—
—
0
0
10
47
2.15
1.34
1.4
1.2
—
—
—
0
0
70
547
1.32
1.32
1.2
1.3
—
—
—
0
0
62
476
1.34
1.32
4.1
3.9
3.6
31.0
ug/l
0.97
46
389
210
1866
1.20
1.30
2.7
2.7
131.1
125.3
ug/l
0.12
190
1719
119
998
1.25
1.30
4.0
3.7
—
—
—
0
0
428
4067
1.24
1.29
17.1
15.1
40.7
40.1
%
1.05
303
2968
318
2937
1.20
1.29
5.0
4.5
985.4
2347.5
e6/l
—
5
53
34
236
1.47
1.28
9.7
12.7
—
—
—
0
0
51
386
1.35
1.20
2.1
2.5
5.8
7.4
ug/l
0.30
43
343
142
1224
1.22
1.20
4.2
4.2
—
—
—
0
0
198
1762
1.19
1.19
3.5
3.6
21.4
34.2
ng/l
2.49
123
1235
137
1178
1.22
1.18
2.2
2.6
2771.6
7177.0
umol/l
0.89
123
1027
13
223
0.57
1.18
3.6
3.4
—
—
—
0
0
202
1803
1.19
1.17
2.1
2.0
98.3
95.6
pmol/l
0.37
100
916
242
2197
1.18
1.15
4.7
4.9
0.0
0.0
estimate
0.50
45
422
396
3750
1.20
1.15
18.6
17.2
13.6
13.7
%
0.11
391
3678
116
985
1.23
1.13
1.3
1.2
1.6
1.4
u/ml
0.13
27
280
48
364
1.35
1.13
3.5
3.3
—
—
—
0
0
458
4405
1.25
1.11
4.5
4.6
6.0
6.0
mmol/l
0.02
413
4028
7
139
0.50
1.10
1.9
1.5
—
—
—
0
0
6
121
0.49
1.06
2.0
4.2
—
—
—
0
0
7
33
2.14
1.06
1.0
1.2
—
—
—
0
0
163
1441
1.19
1.04
2.9
2.5
68.4
57.1
u/l
0.40
151
1328
9
46
1.97
1.04
2.3
1.8
13.0
16.8
ug/l
—
9
46
155
1365
1.19
1.04
3.2
3.1
—
—
—
0
0
437
4192
1.21
1.03
5.7
5.8
39.2
40.1
mmol/mol
1.41
397
3903
110
939
1.21
1.02
2.6
2.5
8.0
5.1
e6/l
1.13
93
834
45
344
1.34
1.02
2.0
3.4
71.2
77.8
ng/l
0.32
39
304
179
1599
1.18
1.01
3.5
3.6
30.8
128.1
e6/l
2.78
131
1145
5
110
0.45
1.01
2.4
1.5
—
—
—
0
0
138
1206
1.19
1.00
4.9
4.0
0.0
0.0
estimate
0.50
44
416
5
23
2.18
0.98
6.0
2.2
—
—
—
0
0
239
2191
1.16
0.97
3.9
3.6
0.0
0.0
estimate
0.00
43
426
141
1239
1.19
0.96
3.1
3.0
0.7
0.5
e6/l
0.46
113
931
122
1059
1.20
0.96
2.5
2.1
2.8
3.1
mg/l
0.73
103
911
115
998
1.19
0.91
1.8
1.7
0.9
1.2
mg/l
0.75
93
770
6
29
2.08
0.89
1.3
1.5
0.9
1.0
g/l
—
6
29
16
103
1.57
0.88
3.0
1.9
190.2
228.9
pmol/l
1.06
16
97
15
95
1.60
0.88
4.0
2.9
—
—
—
0
0
26
187
1.41
0.87
1.3
1.2
—
—
—
0
0
8
44
1.83
0.86
1.0
1.1
—
—
—
0
0
241
2226
1.15
0.86
4.0
3.7
0.0
0.0
estimate
0.50
44
407
27
196
1.40
0.86
1.0
1.1
—
—
—
0
0
15
96
1.58
0.85
1.9
2.7
—
—
—
0
0
470
4562
1.22
0.85
5.0
4.9
2.8
2.8
mmol/l
0.72
423
4198
51
409
1.27
0.85
2.5
1.8
366.6
379.8
nmol/l
0.17
46
378
8
45
1.79
0.84
2.3
3.3
—
—
—
0
0
8
140
0.57
0.84
1.9
1.4
—
—
—
0
0
8
140
0.57
0.84
1.9
1.5
—
—
—
0
0
8
141
0.56
0.83
1.9
1.5
—
—
—
0
0
43
338
1.30
0.83
1.2
1.2
—
—
—
0
0
62
514
1.23
0.79
2.5
2.7
9.7
8.5
umol/l
0.13
55
450
0
27
0.00
0.77
0.0
1.2
—
1.8
—
0
27
147
1321
1.15
0.76
3.5
3.9
—
—
—
0
0
61
507
1.23
0.76
1.4
1.7
—
—
—
0
0
460
4467
1.19
0.76
4.4
4.5
4.8
4.7
mmol/l
1.23
418
4132
53
434
1.24
0.75
1.7
1.5
—
—
—
0
0
13
83
1.58
0.75
1.0
1.3
—
—
—
0
0
13
83
1.58
0.75
1.6
1.5
—
—
—
0
0
5
24
2.09
0.74
1.0
1.1
—
—
—
0
0
154
1394
1.15
0.72
5.2
4.7
2.3
2.5
ug/l
0.25
142
1249
7
40
1.76
0.71
1.0
1.0
—
1.0
—
0
11
7
40
1.76
0.71
1.1
1.5
—
—
—
0
0
5
26
1.93
0.71
2.0
2.1
—
—
—
0
0
5
91
0.55
0.67
3.2
1.7
—
—
—
0
0
7
43
1.64
0.67
1.4
1.3
—
—
—
0
0
11
70
1.58
0.65
1.5
1.4
—
—
—
0
0
42
342
1.25
0.64
3.3
3.1
120.8
180.8
ng/l
0.96
37
313
8
130
0.61
0.64
1.9
1.5
—
—
—
0
0
8
51
1.58
0.60
1.9
2.5
—
—
—
0
0
0
20
0.00
0.60
0.0
2.4
—
53.6
—
0
13
36
291
1.25
0.60
1.3
1.7
2.3
1.4
g/l
0.63
27
269
63
541
1.19
0.59
1.9
2.3
82.5
141.0
ug/g
1.43
51
421
68
588
1.18
0.59
24.4
21.9
1.5
1.2
inr
—
8
79
71
618
1.17
0.57
1.2
1.3
773.3
527.0
titre
—
9
137
42
348
1.22
0.57
2.3
2.6
9.9
10.6
g/l
0.70
37
316
11
74
1.50
0.53
1.4
1.4
—
—
—
0
0
38
314
1.23
0.53
2.8
2.5
—
—
—
0
0
93
832
1.14
0.53
3.5
2.8
2.5
2.5
mmol/l
0.13
78
731
6
39
1.54
0.53
1.0
1.1
—
—
—
0
0
117
1065
1.13
0.51
1.5
1.5
20.6
21.2
nmol/l
0.14
93
898
19
144
1.33
0.51
1.0
1.1
—
—
—
0
0
6
41
1.47
0.50
2.0
1.8
—
—
—
0
0
6
41
1.47
0.50
1.0
1.1
—
—
—
0
0
14
101
1.40
0.50
1.1
1.2
3.8
3.8
mmol/l
0.02
14
92
98
886
1.13
0.48
1.3
1.4
2.2
2.5
g/l
0.72
53
549
7
48
1.46
0.47
1.9
1.3
377.6
350.5
pmol/l
—
7
40
24
297
0.80
0.46
3.2
2.8
—
—
—
0
0
45
386
1.18
0.45
5.4
3.9
—
—
—
0
0
16
121
1.33
0.44
1.0
1.2
—
—
—
0
0
43
368
1.18
0.44
2.7
2.9
66.9
67.1
g/l
0.05
38
330
13
174
0.74
0.44
1.0
1.1
—
—
—
0
0
14
104
1.36
0.43
1.6
1.8
—
—
—
0
0
11
78
1.42
0.43
1.3
1.2
—
—
—
0
0
8
56
1.43
0.42
1.5
1.6
—
—
—
0
0
8
56
1.43
0.42
1.5
1.6
—
—
—
0
0
8
56
1.43
0.42
1.5
1.6
—
—
—
0
0
8
56
1.43
0.42
1.5
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
2.3
—
—
—
0
0
5
36
1.39
0.38
1.8
1.4
—
—
—
0
0
49
433
1.14
0.36
3.7
4.2
—
—
—
0
0
10
134
0.74
0.35
1.0
2.1
11.7
12.0
mg/l
—
10
122
6
43
1.40
0.35
2.5
2.2
—
—
—
0
0
6
43
1.40
0.35
1.0
1.4
5.9
6.5
g/l
—
6
32
6
43
1.40
0.35
1.0
1.4
0.2
0.3
g/l
—
6
31
55
492
1.13
0.34
2.0
2.7
1.6
1.8
%
1.03
45
442
6
89
0.67
0.33
1.0
2.8
—
—
—
0
0
14
110
1.28
0.32
1.1
1.3
566.0
448.6
mg/l
1.06
14
102
210
2012
1.07
0.31
9.1
9.4
0.0
0.0
e9/l
0.54
168
1664
139
1312
1.08
0.31
3.1
3.2
510.2
290.1
mg/l
0.18
91
821
7
99
0.70
0.31
3.3
2.2
—
—
—
0
0
7
54
1.30
0.30
1.3
1.4
—
—
—
0
0
100
932
1.09
0.30
1.6
1.7
468.0
14230708.7
pmol/l
0.80
82
773
130
1226
1.08
0.30
1.7
1.6
1.3
1.4
mmol/l
1.54
113
1023
451
4442
1.09
0.29
4.4
4.4
1.5
1.5
mmol/l
1.52
411
4089
88
817
1.09
0.29
3.5
2.9
0.7
0.7
ug/l
0.17
65
522
73
673
1.10
0.28
2.3
2.3
14.5
13.1
umol/l
0.78
63
629
8
62
1.29
0.28
1.8
1.3
—
—
—
0
0
44
489
0.89
0.27
1.6
1.6
—
—
—
0
0
8
64
1.25
0.27
1.0
1.1
—
—
—
0
0
32
281
1.15
0.27
6.2
3.6
5.2
5.2
kpa
0.15
27
264
35
394
0.88
0.27
1.3
1.4
—
—
—
0
0
17
202
0.84
0.25
1.9
1.7
—
—
—
0
0
6
82
0.73
0.24
1.3
1.7
—
—
—
0
0
15
124
1.22
0.24
1.1
1.3
—
—
—
0
0
13
158
0.82
0.24
1.2
1.3
1.1
1.2
g/l
0.36
13
150
137
1307
1.06
0.23
2.9
3.1
750.8
1174.2
ng/l
1.82
112
1105
45
409
1.11
0.23
2.9
3.3
—
—
—
0
0
25
285
0.87
0.23
1.2
1.2
184.6
115.5
iu/ml
0.39
12
114
5
39
1.28
0.23
1.0
1.3
—
—
—
0
0
143
1368
1.06
0.23
3.2
3.1
17.7
121.0
e6/l
1.43
111
1063
7
91
0.77
0.22
1.0
1.2
—
—
—
0
0
29
325
0.89
0.22
1.6
1.5
—
—
—
0
0
31
277
1.13
0.21
6.4
3.6
7.4
7.4
ph
—
6
35
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
4.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
5
43
1.16
0.21
1.0
1.4
2.4
2.7
g/l
—
5
31
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
3.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.8
—
—
—
0
0
6
49
1.23
0.20
1.2
1.1
—
—
—
0
0
22
193
1.15
0.20
2.0
1.8
—
—
—
0
0
23
260
0.88
0.20
1.4
1.5
—
—
—
0
0
6
51
1.18
0.19
1.0
1.1
—
—
—
0
0
6
52
1.16
0.19
1.2
1.2
—
—
—
0
0
62
580
1.08
0.19
2.3
2.3
23.9
22.7
%
0.30
48
504
7
59
1.19
0.18
1.6
1.4
41.4
32.4
g/l
—
7
50
434
4291
1.06
0.18
4.0
4.0
1.2
1.3
mmol/l
1.02
399
3935
34
310
1.10
0.18
2.9
2.8
3.6
4.0
e9/l
1.10
27
246
10
82
1.22
0.17
3.3
1.6
—
—
—
0
0
10
82
1.22
0.17
1.1
1.3
—
—
—
0
0
143
1383
1.05
0.16
3.7
4.0
5.4
8.2
mg/mmol
0.44
94
860
34
313
1.09
0.15
1.6
1.4
—
—
—
0
0
9
79
1.14
0.15
2.7
3.2
3.5
4.3
e9/l
—
9
79
9
82
1.10
0.15
1.0
1.6
—
—
—
0
0
10
84
1.19
0.14
3.1
3.5
55.2
58.4
%
—
10
84
15
170
0.88
0.14
1.9
2.9
—
—
—
0
0
143
1389
1.04
0.13
3.1
3.1
7.7
7.5
mmol/l
0.18
121
1158
38
357
1.07
0.11
2.0
2.9
59.8
71.3
e9/l
2.61
29
270
36
382
0.94
0.10
3.6
4.0
1.2
1.2
mmol/l
0.46
26
336
5
44
1.14
0.10
2.2
2.7
—
—
—
0
0
5
45
1.11
0.10
1.0
1.4
—
—
—
0
0
7
65
1.08
0.08
3.7
6.4
361.7
375.5
umol/l
—
7
58
23
215
1.07
0.07
2.3
2.3
1.5
1.2
%
0.28
23
215
6
75
0.80
0.07
1.0
1.1
—
—
—
0
0
6
75
0.80
0.07
1.0
1.1
—
—
—
0
0
8
77
1.04
0.07
4.1
2.2
—
—
—
0
0
64
620
1.04
0.07
2.3
2.2
2.4
2.4
g/l
0.05
57
579
9
86
1.05
0.07
1.0
1.1
—
—
—
0
0
35
366
0.95
0.06
5.3
4.4
0.1
0.1
%
0.22
12
106
92
899
1.03
0.06
2.4
2.7
522.5
553.4
mosm/kgh2o
0.81
75
765
41
395
1.04
0.05
5.6
4.2
0.6
0.9
%
0.54
14
120
27
257
1.05
0.05
1.1
1.2
—
—
—
0
0
16
149
1.08
0.05
1.7
1.6
—
—
—
0
0
56
575
0.97
0.05
1.4
1.6
—
—
—
0
0
46
473
0.97
0.04
1.8
1.7
—
—
—
0
0
56
547
1.03
0.04
1.4
1.5
—
—
—
0
0
12
111
1.08
0.04
3.1
4.3
—
—
—
0
0
44
428
1.03
0.04
1.3
1.4
—
—
—
0
0
36
349
1.03
0.03
4.7
4.2
0.4
0.4
%
—
9
80
100
987
1.02
0.03
4.8
3.9
1.0
1.0
kg/l
—
9
132
14
148
0.94
0.02
1.2
1.3
0.2
0.2
g/l
0.29
14
142
33
338
0.97
0.01
5.1
4.5
0.0
0.1
%
—
10
88
12
127
0.94
0.01
1.0
1.1
—
—
—
0
0
122
1229
0.99
0.01
3.4
3.3
—
—
—
0
0
12
114
1.05
0.00
1.9
1.5
16210.4
17430.7
e6/l
—
7
84
14
135
1.04
0.00
1.1
1.2
—
—
—
0
0
16
155
1.03
0.00
7.2
9.8
—
—
—
0
0
20
205
0.97
0.00
7.5
3.7
—
—
—
0
0
32
315
1.02
0.00
1.4
1.7
—
—
—
0
0
13
128
1.02
0.00
1.9
2.6
362.1
70.4
ug/min
—
7
76
70
699
1.00
0.00
1.6
1.8
—
—
—
0
0
6
65
0.92
0.00
2.8
2.9
—
—
—
0
0
5
58
0.86
0.00
2.2
2.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
9
96
0.94
0.00
3.8
2.2
9.3
8.1
kpa
—
9
87
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
2318.5
—
0
8
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
17.9
—
0
7
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
0.00
0.0
4.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
16.8
—
0
8

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_PERIPH_AUTO_NEURO and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_PERIPH_AUTO_NEURO 1.074 [0.83, 1.39] 0.589
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 883 females with CD2_BENIGN_PERIPH_AUTO_NEURO died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_PERIPH_AUTO_NEURO 1.103 [0.85, 1.43] 0.46
Birth year 0.985 [0.97, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 80 out of 763 males with CD2_BENIGN_PERIPH_AUTO_NEURO died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_PERIPH_AUTO_NEURO.

N-year risk Females Males
1 0.081% 0.203%
5 0.509% 1.092%
10 1.267% 2.805%
15 2.412% 5.409%
20 3.959% 9.269%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_PERIPH_AUTO_NEURO – Benign neoplasm: Peripheral nerves and autonomic nervous system

GWS hits: 4

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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