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This is a non-core endpoint: only basic statistics are computed.

Carcinoma in situ of bronchus and lung

Endpoint Browser

CD2_INSITU_BRONCHUSLUNG_EXALLC

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

  • not C3_BRONCHUS_LUNG
-

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D02.2&
  • Hospital discharge: ICD-9 — 2312
  • Cause of death: ICD-10 — D02.2&
  • Cause of death: ICD-9 — 2312
  • Cancer registry: Topography ICD-O-3 — C34
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 2

3 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9
Parent code in ICD-10
D02
Name in latin
Carcinoma in situ mammae

Case counts by codes

↥

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population - - -
Only index persons - - -
Unadjusted period prevalence (%)
Whole population - - -
Only index persons - - -
Median age at first event (years)
Whole population - - -
Only index persons - - -

-FinnGen-

Key figures

All Female Male
Number of individuals 44 16 28
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 69.10 68.65 69.36

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
15
8
27.43
11.22
1.5
1.1
—
—
—
0
0
28
92
6.62
8.91
2.9
1.6
—
—
—
0
0
12
25
6.22
5.89
1.5
1.1
—
—
—
0
0
30
138
4.69
5.64
10.8
7.9
1.3
1.3
inr
—
5
40
29
134
4.41
5.33
6.4
3.7
35.1
34.8
g/l
0.13
29
126
12
29
5.31
4.99
1.3
1.3
—
—
—
0
0
22
92
3.78
4.48
3.6
3.9
—
—
—
0
0
22
95
3.63
4.22
3.5
1.9
—
—
—
0
0
31
168
3.86
4.18
11.9
4.2
19.8
12.9
umol/l
0.34
31
157
32
188
3.57
3.58
9.7
6.3
4.6
4.5
e9/l
0.02
32
159
14
53
3.41
3.16
1.7
1.8
—
—
—
0
0
7
12
6.70
3.15
2.1
1.8
—
—
—
0
0
21
103
2.99
3.08
3.7
3.7
7.4
7.4
ph
—
6
12
10
31
3.88
2.98
4.1
2.5
—
—
—
0
0
14
56
3.20
2.87
4.1
5.3
—
—
—
0
0
5
7
7.86
2.61
2.0
1.7
—
—
—
0
0
25
150
2.54
2.33
4.1
5.3
62.5
57.6
%
1.22
25
136
24
143
2.49
2.25
4.7
5.2
0.7
0.6
%
0.45
24
126
24
148
2.37
2.03
4.5
5.3
3.2
2.9
%
0.37
24
133
24
148
2.37
2.03
4.7
5.6
9.5
8.5
%
0.80
24
134
20
114
2.38
2.01
3.4
4.9
—
—
—
0
0
11
47
2.79
1.96
1.1
1.7
—
—
—
0
0
5
12
4.55
1.87
9.8
2.8
1.6
1.6
%
—
5
12
15
77
2.44
1.87
4.9
3.4
87.2
84.9
%
0.19
15
77
6
18
3.69
1.81
3.2
2.5
0.2
0.2
g/l
—
6
13
30
211
2.33
1.79
8.4
4.6
7.5
7.0
mmol/l
0.88
30
192
5
13
4.19
1.76
9.8
2.7
0.8
1.0
%
—
5
13
32
233
2.37
1.73
5.2
4.1
—
—
—
0
0
6
20
3.30
1.64
18.7
8.1
—
—
—
0
0
8
33
2.73
1.63
9.6
11.0
113.9
125.2
g/l
—
8
33
9
40
2.56
1.51
15.9
9.9
3.9
1.9
mmol/l
—
9
33
20
128
2.03
1.42
2.6
3.5
573.6
32.3
e6/l
0.48
15
87
6
23
2.85
1.42
5.2
5.1
1.2
1.2
mmol/l
—
6
16
9
44
2.31
1.37
1.6
1.1
—
—
—
0
0
8
36
2.49
1.32
2.3
3.6
—
—
—
0
0
6
25
2.61
1.29
9.5
4.6
—
—
—
0
0
20
141
1.77
0.99
11.7
9.0
0.0
0.0
e9/l
0.47
14
106
15
97
1.83
0.98
2.5
2.7
—
—
—
0
0
6
27
2.41
0.98
16.0
12.6
—
—
—
0
0
6
30
2.15
0.91
1.2
1.6
—
—
—
0
0
8
45
1.95
0.90
1.8
3.2
2.4
2.2
g/l
—
8
39
13
83
1.80
0.87
6.8
3.9
—
—
—
0
0
17
118
1.72
0.87
2.8
2.9
109.1
156.3
ug/l
0.56
17
107
7
42
1.79
0.72
2.1
2.3
1.7
1.5
%
—
7
37
5
27
1.96
0.71
2.6
1.5
441.0
313.7
nmol/l
—
5
22
8
52
1.66
0.64
1.9
3.0
8.0
13.2
umol/l
—
8
44
26
304
0.65
0.63
33.9
14.4
36.6
39.7
%
0.56
16
197
0
21
0.00
0.62
0.0
2.0
—
—
—
0
0
11
78
1.55
0.49
1.4
1.3
—
—
—
0
0
32
352
0.67
0.46
5.5
5.9
2.4
2.6
mmol/l
0.65
27
318
5
31
1.69
0.45
1.2
7.1
9.1
11.5
mmol/l
—
5
31
0
16
0.00
0.42
0.0
1.1
—
—
—
0
0
0
16
0.00
0.42
0.0
4.4
—
—
—
0
0
39
365
1.60
0.40
37.0
15.0
87.2
83.9
umol/l
0.27
39
365
5
36
1.44
0.39
4.8
3.0
—
—
—
0
0
31
340
0.70
0.39
5.0
5.2
4.2
4.4
mmol/l
0.46
25
310
20
167
1.36
0.38
2.2
1.9
108.1
91.8
pmol/l
0.78
14
88
31
339
0.71
0.37
5.2
5.2
1.4
1.5
mmol/l
0.04
26
305
30
329
0.72
0.36
4.8
4.5
1.2
1.2
mmol/l
0.35
24
294
6
45
1.38
0.35
1.2
1.8
—
—
—
0
0
14
113
1.35
0.32
4.9
3.0
—
—
—
0
0
38
358
1.45
0.27
28.8
11.7
—
—
—
0
0
36
340
1.32
0.24
7.0
6.9
42.2
41.3
mmol/mol
0.20
31
311
5
41
1.25
0.23
2.2
2.2
2.6
9.8
ug/l
—
5
33
11
90
1.30
0.22
7.5
3.3
12.9
182.1
ng/l
1.36
11
74
0
11
0.00
0.21
0.0
4.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.9
—
22.1
—
0
7
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
3.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
19
168
1.23
0.20
9.3
5.5
0.0
0.0
estimate
—
6
21
39
375
1.35
0.18
35.7
15.7
4.0
4.0
mmol/l
0.33
39
359
39
373
1.40
0.18
35.7
15.7
138.7
139.8
mmol/l
1.09
39
357
11
92
1.26
0.18
4.5
4.3
—
—
—
0
0
19
171
1.20
0.16
6.2
3.9
0.0
0.0
estimate
—
5
18
9
107
0.80
0.15
4.4
3.3
—
—
—
0
0
12
105
1.20
0.13
3.9
3.5
—
—
—
0
0
18
164
1.17
0.12
6.5
3.9
0.0
0.0
estimate
—
6
21
13
143
0.87
0.09
4.3
4.1
0.7
7.8
mg/mmol
—
6
91
39
379
1.25
0.09
43.6
18.6
7.3
6.7
e9/l
1.13
39
363
39
379
1.25
0.09
43.6
18.6
242.2
235.4
e9/l
0.29
39
365
39
379
1.25
0.09
43.4
18.7
4.3
4.5
e12/l
1.49
39
360
39
379
1.25
0.09
43.4
18.6
92.5
91.5
fl
0.66
39
369
39
379
1.25
0.09
43.3
18.5
30.7
30.5
pg
0.30
39
369
39
379
1.25
0.09
45.1
18.8
131.4
137.1
g/l
1.50
39
368
28
270
1.10
0.05
5.9
4.3
—
—
—
0
0
13
133
0.97
0.00
6.8
3.9
—
—
—
0
0
13
132
0.98
0.00
3.2
3.2
8.0
7.6
mmol/l
—
7
108
13
132
0.98
0.00
3.2
3.1
7.9
62.3
mg/l
—
6
86
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
4.1
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
107.4
—
0
5
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
3.6
—
10.1
—
0
5
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_INSITU_BRONCHUSLUNG_EXALLC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_INSITU_BRONCHUSLUNG_EXALLC.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: CD2_INSITU_BRONCHUSLUNG_EXALLC – Carcinoma in situ of bronchus and lung

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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