Disorders of sexual preference

F5_SEXPREF

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 F65
  • Hospital discharge: ICD-9 302[1-2]|3024|3028|3029
  • Hospital discharge: ICD-8 302
  • Hospital discharge: excluded ICD-8 3023
  • Cause of death: ICD-10 F65
  • Cause of death: ICD-9 302[1-2]|3024|3028|3029
  • Cause of death: ICD-8 302
  • Cause of death: excluded ICD-8 3023

2 out of 7 registries used, show all original rules.

82

4. Check minimum number of events

None

82

5. Include endpoints

None

82

6. Filter based on genotype QC (FinnGen only)

73

Control definitions (FinnGen only)

Control exclude
F5_PERSOBEH

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F63-F69
Name in latin
Perturbationes praeferentiae sexualis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 921 154 755
Only index persons 675 116 559
Unadjusted period prevalence (%)
Whole population 0.02 0.00 0.02
Only index persons 0.02 0.00 0.02
Median age at first event (years)
Whole population 31.68 28.72 32.05
Only index persons 29.04 23.76 30.13

-FinnGen-

Key figures

All Female Male
Number of individuals 73 10 63
Unadjusted period prevalence (%) 0.03 0.00 0.03
Median age at first event (years) 35.18 29.01 36.16

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
82
Matched controls
820
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
12.5
22.9
27
31
F65.4
ICD-10 Finland
Paedophilia
+∞
18.4
17
*
30200
ICD-8 Finland
Sexual deviation, Homosexuality
+∞
13.9
13
*
N06AB03
ATC
fluoxetine; oral
7.4
13.3
23
41
30299
ICD-8 Finland
Sexual deviation, Unspecified
+∞
12.8
12
*
N03AG01
ATC
valproic acid; systemic, rectal
14.1
11.3
19
17
N06AB04
ATC
citalopram; systemic
5.3
11.1
30
81
N05AH03
ATC
olanzapine; systemic
10.9
10.9
21
25
N05BA04
ATC
oxazepam; oral
4.8
10.7
34
105
N05AH04
ATC
quetiapine; oral
5.0
10.0
28
77
30041
ICD-8 Finland
Neuroses, Depressiva
112.5
9.6
10
*
F61.0
ICD-10 Finland
Mixed personality disorders
+∞
9.6
9
*
T36
ICD-10 Finland
Poisoning by systemic antibiotics
18.4
9.4
14
9
N05CD07
ATC
temazepam; oral
5.3
8.8
21
50
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
31.3
8.7
11
*
30188
ICD-8 Finland
Personality disorders, Alia definita
+∞
8.5
8
*
N05BA01
ATC
diazepam; systemic, rectal
5.0
8.2
21
53
N05AD01
ATC
haloperidol; systemic
15.3
7.7
12
9
F65.0
ICD-10 Finland
Fetishism
+∞
7.4
7
*
N05AA02
ATC
levomepromazine; systemic
8.5
7.1
15
21
N05AF03
ATC
chlorprothixene; systemic
18.7
6.9
10
6
N05AB03
ATC
perphenazine; systemic, rectal
13.9
6.8
11
9
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.5
6.7
32
127
N05AA01
ATC
chlorpromazine; systemic, rectal
19.9
6.4
9
5
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
29.2
6.4
8
*
30170
ICD-8 Finland
Personality disorders, Antisocial
+∞
6.3
6
*
F65.9
ICD-10 Finland
Disorder of sexual preference, unspecified
+∞
6.3
6
*
K08.3
ICD-10 Finland
Retained dental root
6.1
6.1
16
31
F32.9
ICD-10 Finland
Depressive episode, unspecified
4.6
6.0
16
41

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
35
161
3.05
5.55
12.7
5.6
—
—
—
0
0
8
9
9.69
4.38
5.8
2.0
—
—
—
0
0
7
8
9.42
3.85
35.1
18.3
1035.86
888.38
nmol/l
—
7
8
7
8
9.42
3.85
27.1
13.3
626.43
620.63
nmol/l
—
7
8
7
11
6.84
3.25
14.6
2.6
7.59
8.51
kpa
—
7
11
6
10
6.37
2.75
2.5
2.8
—
—
—
0
0
30
173
2.16
2.66
4.7
4.7
—
—
—
0
0
42
277
2.06
2.61
9.1
8.9
1.21
1.21
mmol/l
0.03
37
238
7
16
4.68
2.53
6.4
1.9
—
—
—
0
0
8
22
3.91
2.43
5.8
1.5
—
—
—
0
0
15
68
2.48
2.27
2.1
1.7
—
—
—
0
0
16
75
2.41
2.26
10.0
7.9
104.38
104.57
mmol/l
0.05
16
75
9
30
3.24
2.22
5.2
1.7
—
—
—
0
0
9
30
3.24
2.22
5.2
1.7
—
—
—
0
0
9
30
3.24
2.22
5.7
1.7
—
—
—
0
0
9
30
3.24
2.22
5.2
1.7
—
—
—
0
0
9
30
3.24
2.22
5.2
1.7
—
—
—
0
0
43
299
1.92
2.19
10.1
6.2
—
—
—
0
0
6
15
4.23
2.08
2.5
2.3
29.47
24.61
mmol/l
—
6
15
43
303
1.88
2.07
14.1
9.2
0.00
0.01
e9/l
0.36
37
246
32
206
1.91
2.02
3.8
3.2
9.85
8.69
mmol/l
0.35
25
178
33
221
1.83
1.81
5.6
3.0
166.05
47.67
e6/l
0.68
22
163
22
129
1.96
1.80
3.2
2.9
—
—
—
0
0
15
260
0.48
1.77
5.3
2.8
—
—
—
0
0
31
207
1.80
1.70
2.5
1.8
86.99
95.77
pmol/l
0.56
19
115
21
125
1.91
1.64
3.5
3.5
—
—
—
0
0
41
300
1.73
1.63
3.2
3.4
0.43
0.00
estimate
—
7
52
11
52
2.29
1.52
13.5
8.3
—
—
—
0
0
40
296
1.69
1.50
4.7
4.5
0.00
0.00
estimate
—
6
59
9
39
2.47
1.48
3.3
4.3
128.11
132.23
g/l
—
9
39
13
67
2.12
1.48
1.6
1.4
—
—
—
0
0
10
46
2.34
1.46
10.7
2.9
6.12
5.10
kpa
—
10
46
5
17
3.06
1.38
1.2
1.2
—
—
—
0
0
28
192
1.70
1.37
2.8
3.3
44.78
405.23
mg/l
0.56
19
134
8
34
2.50
1.33
1.3
2.4
—
—
—
0
0
6
24
2.61
1.33
2.2
1.6
—
—
—
0
0
5
19
2.73
1.23
2.0
3.6
—
—
—
0
0
8
38
2.22
1.22
1.6
2.2
—
—
—
0
0
0
34
0.00
1.19
0.0
1.4
—
—
—
0
0
27
191
1.62
1.15
5.3
2.5
0.53
0.28
e6/l
0.48
21
141
7
32
2.30
1.11
3.9
4.6
25.61
24.43
mmol/l
—
7
32
9
46
2.07
1.08
11.3
2.9
—
7.44
—
0
7
10
53
2.01
1.06
2.6
1.8
341.00
359.09
nmol/l
—
10
46
7
34
2.16
1.05
3.3
2.4
0.54
0.71
%
—
7
34
7
35
2.09
1.03
3.3
2.4
1.20
1.56
%
—
7
35
71
641
1.80
1.00
5.6
4.3
6.33
6.11
mmol/l
0.57
65
583
20
137
1.61
0.96
2.4
1.6
0.68
0.84
mg/l
0.36
13
105
25
181
1.55
0.95
5.4
2.4
—
—
—
0
0
24
174
1.54
0.91
3.5
3.6
7.39
7.40
ph
—
5
34
38
304
1.47
0.90
7.2
13.3
1.17
1.23
inr
—
9
84
37
295
1.46
0.89
3.4
3.4
0.00
0.00
estimate
—
7
63
49
415
1.45
0.84
5.6
3.6
—
—
—
0
0
29
224
1.46
0.81
2.8
2.5
178.83
161.10
ug/l
0.16
29
208
0
26
0.00
0.80
0.0
1.2
—
—
—
0
0
17
117
1.57
0.80
1.5
1.8
—
—
—
0
0
27
208
1.44
0.76
3.3
3.8
4.98
11.66
mg/mmol
0.93
17
141
5
25
2.06
0.74
4.2
4.9
—
—
—
0
0
7
42
1.73
0.70
1.3
1.7
—
—
—
0
0
14
95
1.57
0.69
1.7
2.4
11.58
14.20
umol/l
0.72
14
88
13
87
1.59
0.68
1.6
2.4
2.41
2.37
g/l
0.07
13
77
12
79
1.61
0.67
2.8
1.8
—
—
—
0
0
53
468
1.37
0.64
4.4
3.7
—
—
—
0
0
8
51
1.63
0.63
1.4
1.5
—
—
—
0
0
8
53
1.56
0.60
3.3
1.8
—
—
—
0
0
26
207
1.37
0.60
5.5
2.6
50.97
40.41
e6/l
0.09
19
156
11
73
1.59
0.60
2.2
1.8
—
—
—
0
0
6
35
1.77
0.59
16.5
2.8
—
—
—
0
0
31
255
1.35
0.58
3.4
3.8
38.57
27.79
ng/l
0.20
23
179
13
93
1.47
0.52
1.2
1.2
6.86
26.63
iu/ml
—
7
35
7
50
1.44
0.46
4.0
3.9
—
—
—
0
0
8
55
1.50
0.44
1.3
1.5
—
—
—
0
0
17
213
0.75
0.44
3.0
2.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
70
665
1.36
0.37
19.8
13.3
17.56
24.25
mg/l
1.62
64
523
10
73
1.42
0.36
11.5
14.5
6.34
4.89
kpa
—
10
68
11
84
1.36
0.32
1.3
1.3
—
—
—
0
0
5
72
0.67
0.27
1.8
1.2
—
—
—
0
0
9
73
1.26
0.26
12.7
14.6
1.73
1.28
mmol/l
—
9
54
72
695
1.29
0.25
26.8
15.2
139.15
139.67
mmol/l
1.02
72
677
68
653
1.24
0.24
4.5
3.9
1.58
1.35
mmol/l
1.16
63
598
0
11
0.00
0.21
0.0
3.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
600.83
—
0
12
0
13
0.00
0.21
0.0
3.5
—
—
—
0
0
0
13
0.00
0.21
0.0
2.5
—
—
—
0
0
6
50
1.22
0.20
2.0
1.3
—
—
—
0
0
15
174
0.83
0.20
3.3
3.0
—
—
—
0
0
6
51
1.19
0.20
3.5
3.8
—
—
—
0
0
19
167
1.18
0.19
1.6
1.3
—
—
—
0
0
10
82
1.25
0.18
1.2
1.6
—
—
—
0
0
5
66
0.74
0.17
1.0
1.5
—
—
—
0
0
5
66
0.74
0.17
1.0
1.3
—
350.59
—
0
17
37
395
0.88
0.17
3.2
4.2
1.59
2.48
ug/l
0.53
31
357
10
84
1.22
0.14
1.8
2.4
18.88
24.06
%
—
10
74
11
94
1.20
0.14
1.8
2.3
—
—
—
0
0
14
124
1.16
0.12
1.1
1.3
2.81
2.32
g/l
—
6
72
5
45
1.12
0.10
1.4
14.2
—
—
—
0
0
72
707
1.15
0.09
18.8
12.5
—
—
—
0
0
75
752
0.97
0.08
36.2
18.9
4.66
4.69
e12/l
0.17
75
730
75
752
0.97
0.08
36.1
18.9
90.34
90.77
fl
0.37
75
740
75
752
0.97
0.08
36.2
19.0
139.64
142.09
g/l
0.72
75
739
75
752
0.97
0.08
36.0
18.8
30.18
30.48
pg
0.63
75
740
18
178
1.01
0.00
4.4
4.1
—
—
—
0
0
19
191
0.99
0.00
2.9
2.4
—
—
—
0
0
0
8
0.00
0.00
0.0
2.4
—
119.25
—
0
8
7
72
0.97
0.00
1.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.7
—
1.00
—
0
8
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
11.52
—
0
6
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
75
751
0.98
-0.00
36.1
18.9
247.89
235.21
e9/l
1.08
75
730
5
51
0.98
-0.00
4.4
3.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
1748.00
—
0
5
0
9
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
33.33
—
0
6
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
1.51
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.4
—
147.20
—
0
5

Mortality – FinRegistry

Association

Association between endpoint F5_SEXPREF and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have F5_SEXPREF.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: F5_SEXPREF – Disorders of sexual preference

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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