Other cranial nerve disorders in other disorders

G6_CRAINOTH

cranial nerve palsy: Injury to any of the cranial nerves or their nuclei in the brain resulting in muscle weakness.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G53, G53.0B02.20, G53.0B02.21 Hospital discharge:* excluded ICD-10 — G53.0, G53.0B02.20, G53.0B02.21 Cause of death:* ICD-10 — G53, G53.0B02.20, G53.0B02.21 Cause of death:* excluded ICD-10 — G53.0, G53.0B02.20, G53.0*B02.21 2 out of 7 registries used, show all original rules.	96
4. Check minimum number of events None	96
5. Include endpoints None	96
6. Filter based on genotype QC (FinnGen only)	96

Control definitions (FinnGen only)

Control exclude: G6_NERPLEX

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2

NAME	G6_CRAINOTH
CONTROL_EXCLUDE	G6_NERPLEX
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G53
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL	G530
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G53
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL	G530
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other cranial nerve disorders in other disorders based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	548	312	234
Only index persons	506	292	214
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	50.47	51.53	48.97
Only index persons	48.97	49.40	48.38

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	96	55	41
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	47.98	46.40	50.09

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
84: Matched controls
839

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G53.2*D86.8

ICD-10 Finland

Multiple cranial nerve palsies in sarcoidosis

+∞

63.9

D86.8

ICD-10 Finland

Sarcoidosis of other and combined sites

207.5

49.1

D86.9

ICD-10 Finland

Sarcoidosis, unspecified

160.4

31.1

132

Kela drug reimbursment

Sarcoidosis

130.1

26.5

D86.0

ICD-10 Finland

Sarcoidosis of lung

97.5

25.6

G51.0

ICD-10 Finland

Bell palsy

+∞

20.7

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

17.7

19.7

TAB00

NOMESCO Finland

Lumbar puncture

31.6

19.1

G53.2

ICD-10 Finland

Multiple cranial nerve palsies in sarcoidosis

+∞

17.3

D86.2

ICD-10 Finland

Sarcoidosis of lung with sarcoidosis of lymph nodes

56.4

15.8

Z01.0

ICD-10 Finland

Examination of eyes and vision

9.7

15.0

H02AB06

ATC

prednisolone; systemic

5.9

12.6

282

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

32.3

12.6

L04AX01

ATC

azathioprine; systemic

18.4

12.5

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

5.3

11.2

145

GD1AA

NOMESCO Finland

Thorax X-ray examination

5.0

11.1

222

H04.10

ICD-10 Finland

Dry eye syndrome

9.6

10.2

M05BA04

ATC

alendronic acid; oral

8.9

9.8

D86.1

ICD-10 Finland

Sarcoidosis of lymph nodes

27.6

9.2

G53.1

ICD-10 Finland

Multiple cranial nerve palsies in infectious and parasitic diseases classified elsewhere

+∞

8.5

D86.3

ICD-10 Finland

Sarcoidosis of skin

+∞

8.5

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

9.1

7.8

R20.2

ICD-10 Finland

Paraesthesia of skin

9.9

7.7

R42

ICD-10 Finland

Dizziness and giddiness

4.6

7.6

AA1CM

NOMESCO Finland

Extensive MRI examination of brain with 3 Tesla magnet

22.3

7.3

N03AX12

ATC

gabapentin; oral

5.2

7.0

TPH04

NOMESCO Finland

Cathetrisation of vein

4.0

6.7

G56.0

ICD-10 Finland

Carpal tunnel syndrome

15.9

6.6

AA1DM

NOMESCO Finland

Very extensive MRI examination of brain with 3 Tesla magnet

75.2

6.5

I41.8*D86.8

ICD-10 Finland

Sarcoid myocarditis

75.2

6.5

M14.8*D86.8

ICD-10 Finland

Arthropathy in sarcoidosis

+∞

6.3

A02BC02

ATC

pantoprazole; systemic

3.5

6.3

402

Z03.3

ICD-10 Finland

Observation for suspected nervous system disorder

6.8

6.2

XCK00

NOMESCO Finland

Perimetry

6.5

6.0

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3044290) Cell count panel - Cerebral spinal fluid

14.57

16.45

1.5

1.2

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

11.05

8.79

1.0

1.1

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

22.54

8.71

1.0

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

22.54

8.71

1.2

1.0

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

333

3.59

8.33

10.1

6.6

1.2

mmol/l

1.04

286

(42870588) Differential panel, method unspecified - Blood

237

3.46

8.30

10.9

5.6

—

(3001604) Monocytes [#/volume] in Blood

381

3.69

8.12

10.8

6.4

0.6

e9/l

0.10

333

(3013115) Eosinophils [#/volume] in Blood

391

3.72

8.08

10.8

6.6

0.2

e9/l

0.47

348

(3006315) Basophils [#/volume] in Blood

382

3.67

8.06

10.8

6.4

0.0

e9/l

0.40

332

(3019198) Lymphocytes [#/volume] in Blood

388

3.58

7.74

10.8

6.5

1.7

2.1

e9/l

0.74

348

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

13.60

6.77

1.0

1.1

—

(4027681)

15.73

6.55

1.2

1.1

—

(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood

6.09

6.47

2.0

1.3

—

0.1

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

3.61

5.83

3.3

1.8

333.8

383.7

nmol/l

0.66

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

12.25

5.41

2.8

3.9

59.9

67.1

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

12.25

5.41

2.7

2.0

4.0

6.5

e9/l

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

449

2.91

5.34

14.0

10.2

3.8

4.1

e9/l

0.57

395

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

4.14

4.54

2.1

0.7

1.0

mmol/l

—

(3016018) Differential panel - Cerebral spinal fluid

12.44

4.34

1.6

1.2

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

12.44

4.34

1.1

1.0

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

274

2.40

4.25

4.2

3.6

17.3

33.5

ng/l

1.56

185

(3023368) Bacteria identified in Blood by Culture

189

2.45

4.08

4.1

3.8

—

(3018418) pH of Serum or Plasma

208

2.37

3.90

8.6

4.0

7.4

0.07

(3023410) Appearance of Cerebral spinal fluid

9.32

3.84

2.0

1.4

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

227

2.31

3.75

1.9

2.1

122.4

174.6

u/l

1.21

213

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

10.55

3.54

3.0

1.7

—

(3026008) Bacteria identified in Urine by Culture

208

2.27

3.51

6.2

2.8

—

(3032080) INR in Blood by Coagulation assay

278

2.16

3.36

14.1

7.6

1.3

1.2

inr

—

(3037522) Nuclear Ab [Titer] in Serum

2.52

3.11

1.6

1.4

406.7

387.4

titre

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

213

2.10

2.93

4.1

2.9

787.7

1519.6

ng/l

0.98

182

(3037467) Urinalysis macro (dipstick) panel - Urine

520

2.16

2.90

8.5

3.8

—

(3052851) Hemolysis interference index of Serum or Plasma

5.30

2.78

3.4

2.9

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

8.70

2.78

1.8

1.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

201

2.07

2.75

7.4

6.0

—

(3020682) Albumin/Creatinine [Ratio] in Urine

235

2.02

2.71

4.5

3.6

4.7

8.4

mg/mmol

0.46

154

(3012516) Albumin [Mass/volume] in Urine

212

2.02

2.63

3.9

3.0

45.8

354.3

mg/l

0.51

146

(3004789) Transferrin [Mass/volume] in Serum or Plasma

2.34

2.60

2.8

2.2

2.3

2.5

g/l

0.43

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.43

2.49

2.2

1.7

—

(3021589) Normoblasts [#/volume] in Blood

352

1.88

2.37

13.4

9.4

0.0

e9/l

0.47

290

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

3.70

2.33

2.0

1.8

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.34

2.29

2.3

1.7

—

(3022313) Gas panel - Capillary blood

3.32

2.29

1.7

2.1

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

5.79

2.24

1.8

1.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

258

1.86

2.21

6.0

2.8

—

(3012544) pH of Venous blood

2.32

2.05

2.7

4.5

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

4.33

1.84

1.6

1.9

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

4.33

1.84

1.6

1.9

—

(3021601) Nitrite [Presence] in Urine by Test strip

394

1.70

1.75

6.4

4.6

0.0

estimate

—

(3015736) pH of Urine

310

1.70

1.74

3.7

3.2

—

(40760888) Immunoglobulin light chains.free panel - Serum

3.99

1.73

5.0

5.4

—

(3035350) Ketones [Presence] in Urine by Test strip

395

1.69

1.73

4.9

3.3

0.0

estimate

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

3.30

1.69

1.7

1.5

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.06

1.67

1.9

1.3

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

132

1.86

1.64

6.1

3.0

21.9

143.0

ng/l

1.31

(3009261) Glucose [Presence] in Urine by Test strip

400

1.65

1.61

4.9

3.3

0.0

estimate

—

(40768804) Tissue Pathology biopsy report

315

1.66

1.61

2.3

2.1

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

133

1.85

1.60

1.8

1.5

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

142

1.81

1.57

1.1

1.2

1.4

4.3

u/ml

—

(1616796) Gas panel - Central venous blood

3.46

1.54

1.6

1.8

—

(3000850) Epithelial cells [#/volume] in Urine

151

1.79

1.54

3.7

2.4

5.9

3.9

e6/l

0.57

138

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.61

1.48

12.7

9.1

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.61

1.48

1.9

2.0

—

(3027945) Reticulocytes/100 erythrocytes in Blood

2.04

1.48

3.3

1.9

1.8

0.36

(3042111) Morphology [Interpretation] in Bone marrow Narrative

3.24

1.45

1.0

1.6

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

3.24

1.45

1.0

2.3

—

(4035726)

2.14

1.45

1.3

1.2

—

(3045414) Leukocytes [Presence] in Urine

2.52

1.42

4.1

1.6

—

(3002256) Pathology report gross observation

1.96

1.41

1.3

1.2

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

107

1.84

1.38

2.2

1.8

—

(3022145) Colonoscopy Study observation

1.93

1.36

1.5

1.4

—

(40761536) Microorganisms panel - Urine sediment

2.03

1.29

5.9

3.1

—

(36304419) Bacteria [Presence] in Urine

193

1.64

1.29

5.0

2.5

—

(3019225) pH of Specimen

2.09

1.28

4.5

3.7

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.16

1.27

1.1

1.7

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

2.72

1.23

4.0

1.5

92.4

94.5

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

324

1.53

1.19

4.5

2.6

161.1

111.9

ug/l

0.68

300

(3042936) Bacteria identified in Isolate by Culture

1.80

1.19

2.6

1.8

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

2.58

1.16

4.4

2.2

2.9

4.0

g/l

—

(3000330) Specific gravity of Urine by Test strip

2.09

1.15

6.1

4.2

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

122

1.69

1.13

4.1

2.2

1.9

1.2

e6/l

0.28

(46235355) HIV 1 and 2 tests - Meaningful Use set

122

1.69

1.13

1.5

1.9

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

337

1.50

1.12

3.8

3.5

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

803

1.89

1.11

22.3

12.3

14.8

23.0

mg/l

2.49

616

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.28

1.10

1.0

1.1

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.10

1.08

1.8

2.4

1.6

1.3

—

(40768443) Skin Pathology biopsy report

2.21

1.08

1.1

1.2

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.05

1.07

6.2

1.5

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

293

1.49

1.06

2.1

1.9

94.0

93.4

pmol/l

0.03

147

(3041096) Erythrocytes [Presence] in Urine by Automated

220

1.53

1.06

5.0

3.0

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

109

1.68

1.02

7.7

2.4

1.6

3.3

e6/l

0.70

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.95

1.01

2.1

3.5

128.2

129.6

g/l

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

152

1.58

1.00

1.1

1.2

11.5

37.2

iu/ml

—

(3013512) EKG study

224

1.49

0.96

4.4

3.4

—

(3033658) Prothrombin time (PT) actual/Normal

189

1.52

0.95

4.6

3.2

94.9

94.0

0.06

184

(40758558) Short blood count panel - Blood

209

1.48

0.90

10.5

5.9

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.00

0.86

2.5

2.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

314

1.41

0.84

4.9

3.4

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

185

1.48

0.83

2.1

1.6

8.0

1.1

mg/l

0.42

149

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

168

1.49

0.81

1.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

513

1.39

0.79

3.8

3.0

—

(3020961) Endomysium IgA Ab [Titer] in Serum

1.81

0.77

1.2

1.1

—

(3044640) Blood type and Crossmatch panel - Blood

216

1.42

0.75

2.1

1.9

—

(3025941) Bacteria identified in Stool by Culture

1.86

0.74

1.4

1.2

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.81

0.73

1.1

1.2

—

(3000991) Gas panel - Venous blood

1.61

0.72

2.9

8.6

—

(40768797) Stomach Pathology biopsy report

103

1.54

0.70

1.1

1.2

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

1.90

0.69

1.0

1.3

—

193.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.55

0.69

1.2

1.5

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.76

0.64

11.2

1.3

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

167

1.41

0.64

1.3

1.2

0.4

2.2

u/ml

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.60

0.0

2.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.53

0.57

1.4

1.8

—

(3000494) Fungus identified in Specimen by Culture

1.50

0.56

1.1

1.5

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.57

0.54

1.2

1.4

—

(21494755) Public health laboratory ask at order entry panel

106

0.63

0.52

1.0

1.4

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.60

0.50

3.9

3.0

59.1

47.8

—

(3019060) Gas panel - Arterial blood

1.46

0.47

10.3

4.6

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

205

0.74

0.46

2.1

3.8

23.3

22.0

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.34

0.41

1.5

1.8

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.40

0.0

1.1

—

(3019150) Specific gravity of Urine by Refractometry

171

1.29

0.40

5.7

3.6

1.0

kg/l

—

(3029937) Albumin [Presence] in Urine by Test strip

218

1.26

0.40

5.4

3.4

0.0

estimate

—

(40761535) Cells panel - Urine sediment

1.38

0.39

2.7

3.7

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

139

0.76

0.29

1.5

2.3

2.4

mmol/l

0.00

125

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

760

0.84

0.25

19.0

11.5

83.2

81.8

ml/min/173m2

0.23

629

(3000492) Spirometry study

1.31

0.25

2.2

1.4

—

(3003694) ABO and Rh group [Type] in Blood

189

0.82

0.25

1.2

1.4

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.37

0.24

2.6

1.4

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.23

0.22

3.2

2.0

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.21

0.0

1.2

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.21

0.0

1.0

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.21

0.0

1.2

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

830

0.85

0.17

5.8

4.7

2.8

mmol/l

0.07

771

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.12

0.16

3.1

3.3

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.17

0.16

1.8

2.3

—

(3022217) INR in Platelet poor plasma by Coagulation assay

0.82

0.14

13.9

24.7

—

1.4

—

(3009542) Hematocrit [Volume Fraction] of Blood

757

0.90

0.11

23.0

12.5

39.6

40.6

0.40

577

(3014007) Fractional oxyhemoglobin in Arterial blood

1.17

0.10

2.6

10.2

93.5

94.0

—

(40761511) CBC panel - Blood by Automated count

847

1.15

0.09

20.1

11.3

—

(4010399)

1.04

0.08

1.7

1.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.14

0.08

8.5

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.09

0.08

1.6

1.4

—

(3044889) 12 lead EKG panel

575

1.07

0.07

4.3

3.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

138

1.10

0.07

1.6

1.4

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

790

1.08

0.04

4.5

3.9

1.5

1.3

mmol/l

1.06

737

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

760

1.07

0.04

8.5

5.3

41.7

39.5

mmol/mol

1.12

718

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

116

0.94

0.01

1.4

1.9

1.1

1.4

0.90

106

(3020564) Creatinine [Moles/volume] in Serum or Plasma

858

1.02

0.00

25.1

14.4

77.2

umol/l

0.00

858

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

792

0.99

0.00

4.8

4.4

6.0

5.9

mmol/l

0.16

731

(1761868) Lipid panel - Serum or Plasma

357

1.01

0.00

3.5

2.7

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

186

1.03

0.00

5.3

3.3

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

0.0

5.0

—

38.0

—

(3017704) Immunofixation for Urine

0.00

0.0

1.2

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.6

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.0

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.2

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

0.0

2.4

—

3.3

—

(3020650) Glucose [Presence] in Urine

0.00

0.0

1.2

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.4

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

1524.2

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.2

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

1.0

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3045716) Anion gap in Serum or Plasma

0.00

0.0

2.0

—

7.3

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.2

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.98

0.00

1.6

2.1

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.4

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.1

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.2

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.1

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.7

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

2.0

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.1

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

3.2

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3027456) Digoxin [Moles/volume] in Serum or Plasma

0.00

0.0

3.1

—

0.8

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.1

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.2

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.2

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.0

2.0

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.0

2.0

—

2.2

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.3

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.2

—

(3011648) Oxygen content in Venous blood

0.00

0.0

2.5

—

12.6

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

13.5

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.3

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

2.1

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

1.1

—

96.6

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.8

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

4.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_CRAINOTH and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_CRAINOTH	2.04 [1.48, 2.81]	< 0.001
Birth year	0.993 [0.98, 1.0]	0.114

During the follow-up period (1.1.1998 — 31.12.2019), 57 out of 292 females with G6_CRAINOTH died.

Males

Parameter	HR [95% CI]	p-value
G6_CRAINOTH	1.899 [1.36, 2.64]	< 0.001
Birth year	0.989 [0.98, 1.0]	0.037

During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 223 males with G6_CRAINOTH died.

Mortality risk

Mortality risk for people of age

years, who have G6_CRAINOTH.

N-year risk	Females	Males
1	0.163%	0.463%
5	1.165%	2.375%
10	2.897%	6.245%
15	5.219%	11.758%
20	9.075%	18.899%

Relationships between endpoints

↥

Index endpoint: G6_CRAINOTH – Other cranial nerve disorders in other disorders

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other cranial nerve disorders in other disorders

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints