Other cranial nerve disorders in other disorders

G6_CRAINOTH

cranial nerve palsy: Injury to any of the cranial nerves or their nuclei in the brain resulting in muscle weakness.

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G53, G53.0B02.20, G53.0B02.21 Hospital discharge:* excluded ICD-10 — G53.0, G53.0B02.20, G53.0B02.21 Cause of death:* ICD-10 — G53, G53.0B02.20, G53.0B02.21 Cause of death:* excluded ICD-10 — G53.0, G53.0B02.20, G53.0*B02.21 2 out of 7 registries used, show all original rules.	96
4. Check minimum number of events None	96
5. Include endpoints None	96
6. Filter based on genotype QC (FinnGen only)	96

Control definitions (FinnGen only)

Control exclude: G6_NERPLEX

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2

NAME	G6_CRAINOTH
CONTROL_EXCLUDE	G6_NERPLEX
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G53
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL	G530
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G53
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL	G530
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Other cranial nerve disorders in other disorders based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	548	312	234
Only index persons	506	292	214
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	50.47	51.53	48.97
Only index persons	48.97	49.40	48.38

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	96	55	41
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	47.98	46.40	50.09

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
84: Matched controls
839

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G53.2*D86.8

ICD-10 Finland

Multiple cranial nerve palsies in sarcoidosis

+∞

63.9

D86.8

ICD-10 Finland

Sarcoidosis of other and combined sites

207.5

49.1

D86.9

ICD-10 Finland

Sarcoidosis, unspecified

160.4

31.1

132

Kela drug reimbursment

Sarcoidosis

130.1

26.5

D86.0

ICD-10 Finland

Sarcoidosis of lung

97.5

25.6

G51.0

ICD-10 Finland

Bell palsy

+∞

20.7

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

17.7

19.7

TAB00

NOMESCO Finland

Lumbar puncture

31.6

19.1

G53.2

ICD-10 Finland

Multiple cranial nerve palsies in sarcoidosis

+∞

17.3

D86.2

ICD-10 Finland

Sarcoidosis of lung with sarcoidosis of lymph nodes

56.4

15.8

Z01.0

ICD-10 Finland

Examination of eyes and vision

9.7

15.0

H02AB06

ATC

prednisolone; systemic

5.9

12.6

282

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

32.3

12.6

L04AX01

ATC

azathioprine; systemic

18.4

12.5

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

5.3

11.2

145

GD1AA

NOMESCO Finland

Thorax X-ray examination

5.0

11.1

222

H04.10

ICD-10 Finland

Dry eye syndrome

9.6

10.2

M05BA04

ATC

alendronic acid; oral

8.9

9.8

D86.1

ICD-10 Finland

Sarcoidosis of lymph nodes

27.6

9.2

G53.1

ICD-10 Finland

Multiple cranial nerve palsies in infectious and parasitic diseases classified elsewhere

+∞

8.5

D86.3

ICD-10 Finland

Sarcoidosis of skin

+∞

8.5

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

9.1

7.8

R20.2

ICD-10 Finland

Paraesthesia of skin

9.9

7.7

R42

ICD-10 Finland

Dizziness and giddiness

4.6

7.6

AA1CM

NOMESCO Finland

Extensive MRI examination of brain with 3 Tesla magnet

22.3

7.3

N03AX12

ATC

gabapentin; oral

5.2

7.0

TPH04

NOMESCO Finland

Cathetrisation of vein

4.0

6.7

G56.0

ICD-10 Finland

Carpal tunnel syndrome

15.9

6.6

AA1DM

NOMESCO Finland

Very extensive MRI examination of brain with 3 Tesla magnet

75.2

6.5

I41.8*D86.8

ICD-10 Finland

Sarcoid myocarditis

75.2

6.5

M14.8*D86.8

ICD-10 Finland

Arthropathy in sarcoidosis

+∞

6.3

A02BC02

ATC

pantoprazole; systemic

3.5

6.3

402

Z03.3

ICD-10 Finland

Observation for suspected nervous system disorder

6.8

6.2

XCK00

NOMESCO Finland

Perimetry

6.5

6.0

Mortality – FinRegistry

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Association

Association between endpoint G6_CRAINOTH and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_CRAINOTH	2.04 [1.48, 2.81]	< 0.001
Birth year	0.993 [0.98, 1.0]	0.114

During the follow-up period (1.1.1998 — 31.12.2019), 57 out of 292 females with G6_CRAINOTH died.

Males

Parameter	HR [95% CI]	p-value
G6_CRAINOTH	1.899 [1.36, 2.64]	< 0.001
Birth year	0.989 [0.98, 1.0]	0.037

During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 223 males with G6_CRAINOTH died.

Mortality risk

Mortality risk for people of age

years, who have G6_CRAINOTH.

N-year risk	Females	Males
1	0.163%	0.463%
5	1.165%	2.375%
10	2.897%	6.245%
15	5.219%	11.758%
20	9.075%	18.899%

Relationships between endpoints

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Index endpoint: G6_CRAINOTH – Other cranial nerve disorders in other disorders

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other cranial nerve disorders in other disorders

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints