Other and unspecified heterotropia

H7_HETEROTRONAS

No definition available.

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H50.4 Cause of death: ICD-10 — H50.4 2 out of 7 registries used, show all original rules.	100
4. Check minimum number of events None	100
5. Include endpoints None	100
6. Filter based on genotype QC (FinnGen only)	100

Control definitions (FinnGen only)

Control exclude: H7_OCUMUSCLE

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H50
Name in latin: Heterotropia alia sive non specificata

NAME	H7_HETEROTRONAS
CONTROL_EXCLUDE	H7_OCUMUSCLE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H504
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H504
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Other and unspecified heterotropia based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	971	511	459
Only index persons	817	435	382
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.02	0.02	0.01
Median age at first event (years)
Whole population	24.32	23.48	25.22
Only index persons	34.01	31.14	37.28

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	100	57	43
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	54.08	51.58	57.40

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
92: Matched controls
922

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H50.4

ICD-10 Finland

Other and unspecified heterotropia

+∞

132.5

H50.2

ICD-10 Finland

Vertical strabismus

+∞

31.0

H53.2

ICD-10 Finland

Diplopia

69.4

26.1

CEC10

NOMESCO Finland

Recession and resection of extraocular muscle

+∞

16.1

XCW99

NOMESCO Finland

Other investigative procedure of eye

8.5

14.3

CEC00

NOMESCO Finland

Recession of extraocular muscle

+∞

13.9

H50.0

ICD-10 Finland

Convergent concomitant strabismus

+∞

12.8

H50.1

ICD-10 Finland

Divergent concomitant strabismus

+∞

11.7

H49.1

ICD-10 Finland

Fourth [trochlear] nerve palsy

+∞

11.7

WX408

NOMESCO Finland

General anesthesy, balanced

4.6

9.8

143

CEC60

NOMESCO Finland

Transposition of extraocular muscle with adjustable suture

+∞

7.4

Z2446

NOMESCO Finland

Social worker

7.2

6.8

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

6.5

6.7

Z2445

NOMESCO Finland

Psychologist

9.3

6.6

H50.30

ICD-10 Finland

Intermittent esotropy

+∞

6.3

CEC85

NOMESCO Finland

Combined correction of cyclodeviation

+∞

6.3

Mortality – FinRegistry

↥

Association

Association between endpoint H7_HETEROTRONAS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_HETEROTRONAS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

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Index endpoint: H7_HETEROTRONAS – Other and unspecified heterotropia

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other and unspecified heterotropia

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints