Other and unspecified heterotropia

H7_HETEROTRONAS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H50.4 Cause of death: ICD-10 — H50.4 2 out of 7 registries used, show all original rules.	100
4. Check minimum number of events None	100
5. Include endpoints None	100
6. Filter based on genotype QC (FinnGen only)	100

Control definitions (FinnGen only)

Control exclude: H7_OCUMUSCLE

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H50
Name in latin: Heterotropia alia sive non specificata

NAME	H7_HETEROTRONAS
CONTROL_EXCLUDE	H7_OCUMUSCLE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H504
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H504
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other and unspecified heterotropia based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	971	511	459
Only index persons	817	435	382
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.02	0.02	0.01
Median age at first event (years)
Whole population	24.32	23.48	25.22
Only index persons	34.01	31.14	37.28

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	100	57	43
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	54.08	51.58	57.40

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
92: Matched controls
922

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H50.4

ICD-10 Finland

Other and unspecified heterotropia

+∞

132.5

H50.2

ICD-10 Finland

Vertical strabismus

+∞

31.0

H53.2

ICD-10 Finland

Diplopia

69.4

26.1

CEC10

NOMESCO Finland

Recession and resection of extraocular muscle

+∞

16.1

XCW99

NOMESCO Finland

Other investigative procedure of eye

8.5

14.3

CEC00

NOMESCO Finland

Recession of extraocular muscle

+∞

13.9

H50.0

ICD-10 Finland

Convergent concomitant strabismus

+∞

12.8

H50.1

ICD-10 Finland

Divergent concomitant strabismus

+∞

11.7

H49.1

ICD-10 Finland

Fourth [trochlear] nerve palsy

+∞

11.7

WX408

NOMESCO Finland

General anesthesy, balanced

4.6

9.8

143

CEC60

NOMESCO Finland

Transposition of extraocular muscle with adjustable suture

+∞

7.4

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

6.5

6.7

CEC85

NOMESCO Finland

Combined correction of cyclodeviation

+∞

6.3

H50.30

ICD-10 Finland

Intermittent esotropy

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3018418) pH of Serum or Plasma

213

2.57

4.83

4.3

3.6

7.4

—

(3019309) Folate [Moles/volume] in Red Blood Cells

117

2.79

4.52

1.4

1.6

1169.9

1159.8

nmol/l

0.02

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

355

2.22

3.73

10.4

8.5

1.2

mmol/l

0.96

302

(40758558) Short blood count panel - Blood

198

2.28

3.57

5.7

8.3

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

131

2.33

3.12

3.6

2.6

0.5

0.8

e6/l

0.51

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

4.39

2.96

1.9

1.6

0.2

g/l

—

(36304419) Bacteria [Presence] in Urine

212

2.09

2.94

4.1

2.8

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

4.19

2.85

2.1

1.6

1.2

g/l

—

(3037467) Urinalysis macro (dipstick) panel - Urine

559

2.13

2.85

4.1

4.6

—

(3018095) Leukocytes [#/volume] in Urine

297

1.94

2.62

4.3

3.7

89.3

55.6

e6/l

0.26

202

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

272

1.94

2.58

3.8

3.2

—

(3044290) Cell count panel - Cerebral spinal fluid

4.62

2.52

2.6

3.3

—

(3002582) Erythrocytes [#/volume] in Urine

248

1.94

2.52

4.0

3.0

154.1

322.3

e6/l

0.26

193

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

128

2.15

2.49

3.9

2.8

2.9

3.5

e6/l

0.09

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.55

2.34

16.2

14.7

24.4

25.0

mmol/l

0.28

(3030467) Casts [#/volume] in Urine by Automated count

220

1.91

2.31

4.2

2.8

0.3

0.4

e6/l

0.22

163

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

298

1.85

2.31

2.1

1.8

101.6

95.5

pmol/l

0.39

147

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

4.83

2.30

1.0

1.3

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

473

1.82

2.16

7.4

5.4

6.5

6.6

mmol/l

0.18

433

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

3.50

2.00

2.1

1.4

—

(3044640) Blood type and Crossmatch panel - Blood

222

1.81

1.95

1.9

2.5

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.12

1.95

1.7

2.0

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

753

2.20

1.91

4.1

4.3

5.8

5.9

mmol/l

0.49

682

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.72

1.85

29.7

8.7

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

3.06

1.75

1.3

1.9

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

819

2.23

1.73

15.9

13.4

29.3

23.5

mg/l

0.72

636

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

3.29

1.69

2.2

1.5

—

(36660697) Celiac disease serology panel - Serum

2.22

1.68

1.1

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

2.93

1.68

4.4

5.0

161.7

210.7

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

180

1.77

1.67

1.3

1.0

0.7

u/ml

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

197

1.75

1.67

2.4

3.6

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.47

1.66

1.1

1.2

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

3.70

1.63

1.2

1.4

—

(3002256) Pathology report gross observation

2.13

1.63

1.4

1.3

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

2.82

1.61

1.1

2.4

314.7

459.2

mg/l

—

(3007164) IgA [Mass/volume] in Serum or Plasma

176

1.73

1.53

1.9

1.6

1.8

2.4

g/l

0.85

102

(3052851) Hemolysis interference index of Serum or Plasma

2.97

1.53

3.5

3.6

—

(3015736) pH of Urine

318

1.62

1.51

2.9

3.8

—

(3044889) 12 lead EKG panel

524

1.61

1.46

4.0

3.6

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

187

1.69

1.45

5.2

4.8

20.6

19.2

0.21

(3000991) Gas panel - Venous blood

2.05

1.41

22.8

10.3

—

(3023511) Choriogonadotropin [Units/volume] in Urine

2.71

1.39

1.3

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

131

1.76

1.37

1.2

1.3

2.1

20.2

u/ml

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

469

1.56

1.36

8.5

10.0

4.2

4.1

e9/l

0.04

411

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

134

1.72

1.27

1.1

1.3

14.5

26.3

iu/ml

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

357

1.53

1.27

3.5

4.3

—

(3011288) Drugs identified in Urine by Screen method

2.49

1.26

1.3

1.6

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

104

1.76

1.19

5.7

8.9

1.0

1.1

mmol/l

0.51

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

1.18

0.0

1.7

—

(3021589) Normoblasts [#/volume] in Blood

390

1.50

1.18

9.1

10.5

0.0

e9/l

0.93

319

(3048689) Calprotectin [Mass/mass] in Stool

113

1.72

1.15

1.8

1.7

67.5

71.0

ug/g

—

(3014007) Fractional oxyhemoglobin in Arterial blood

2.09

1.15

34.5

9.8

91.6

94.6

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

2.43

1.15

1.1

1.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

165

1.60

1.10

2.1

2.5

—

(3049717) Cytology report of Urine Cyto stain

2.45

1.10

4.4

2.2

—

(3005719) IgG [Mass/volume] in Serum or Plasma

1.90

1.10

3.9

3.1

9.9

9.1

g/l

0.30

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.76

1.08

1.5

2.1

—

(3032080) INR in Blood by Coagulation assay

293

1.48

1.04

11.5

9.6

1.1

1.3

inr

2.99

(3000492) Spirometry study

1.84

1.01

2.0

1.5

—

(42870588) Differential panel, method unspecified - Blood

276

1.48

1.01

4.8

7.5

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.99

0.0

1.8

—

(3018010) Neutrophils/100 leukocytes in Blood

401

1.44

0.98

6.0

7.0

57.4

57.2

0.04

382

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

242

1.47

0.96

1.9

2.2

61.4

54.1

u/l

0.53

220

(3016879) Cocaine [Presence] in Urine

1.96

0.96

1.1

1.4

—

(3022096) Basophils/100 leukocytes in Blood

375

1.42

0.92

5.9

7.2

0.6

0.00

356

(3042936) Bacteria identified in Isolate by Culture

104

1.64

0.91

2.3

1.8

—

(3013115) Eosinophils [#/volume] in Blood

417

1.40

0.87

6.1

7.6

0.2

e9/l

0.02

370

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.67

0.87

1.4

2.0

—

(3035350) Ketones [Presence] in Urine by Test strip

419

1.39

0.84

3.5

3.9

0.0

estimate

—

(3021601) Nitrite [Presence] in Urine by Test strip

421

1.38

0.80

4.6

5.5

0.0

estimate

—

(40761511) CBC panel - Blood by Automated count

865

1.79

0.80

12.5

12.4

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.79

0.0

1.6

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.79

0.0

5.7

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

741

1.49

0.79

14.8

12.0

87.7

84.0

ml/min/173m2

0.78

594

(1761868) Lipid panel - Serum or Plasma

289

0.69

0.75

3.2

2.8

—

(3006504) Eosinophils/100 leukocytes in Blood

386

1.36

0.74

6.0

7.3

2.5

2.7

0.34

365

(3022145) Colonoscopy Study observation

1.61

0.73

1.2

1.3

—

(3028300) Cannabinoids [Presence] in Urine

1.81

0.73

1.1

1.4

—

(3027008) Opiates [Presence] in Urine

1.81

0.73

1.1

1.3

—

(3000764) Benzodiazepines [Presence] in Urine

1.81

0.73

1.1

1.4

—

(3002030) Lymphocytes/100 leukocytes in Blood

407

1.34

0.72

6.1

7.3

27.0

28.4

0.39

385

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.97

0.71

1.8

1.1

—

(40768797) Stomach Pathology biopsy report

1.59

0.70

1.2

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

780

1.48

0.69

4.7

4.8

2.7

mmol/l

0.09

712

(3025941) Bacteria identified in Stool by Culture

1.63

0.66

1.3

1.2

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

760

1.44

0.66

3.9

4.2

1.5

1.4

mmol/l

0.55

699

(40768804) Tissue Pathology biopsy report

305

1.34

0.66

2.4

1.9

—

(3019069) Monocytes/100 leukocytes in Blood

392

1.32

0.65

6.2

7.6

8.4

0.01

375

(3019198) Lymphocytes [#/volume] in Blood

422

1.32

0.64

6.1

7.2

1.8

e9/l

0.00

378

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

730

1.39

0.62

3.8

3.9

1.2

1.3

mmol/l

0.28

664

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

150

1.42

0.62

2.4

3.9

1251.1

260.5

ng/l

0.37

113

(3009261) Glucose [Presence] in Urine by Test strip

424

1.31

0.61

3.4

4.0

0.0

estimate

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.58

0.61

1.1

1.0

—

(4010399)

1.63

0.61

2.1

1.3

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.61

0.0

1.9

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.61

0.0

3.4

—

6.7

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.61

0.0

1.3

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.61

0.0

3.6

—

1.4

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

1.76

0.59

1.2

—

(3023368) Bacteria identified in Blood by Culture

208

1.34

0.55

5.4

4.3

—

(3006315) Basophils [#/volume] in Blood

409

1.28

0.55

6.1

7.1

0.0

e9/l

0.02

357

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

768

1.38

0.54

4.2

4.3

4.6

mmol/l

0.33

711

(3001604) Monocytes [#/volume] in Blood

410

1.28

0.54

6.1

7.1

0.5

0.6

e9/l

0.54

356

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.42

0.52

1.9

1.7

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

1.49

0.52

23.8

8.2

5.6

5.0

kpa

0.52

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

137

1.38

0.52

2.6

3.0

1.2

0.7

ug/l

0.36

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

129

1.38

0.50

1.9

2.0

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.49

0.48

2.9

2.5

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.48

0.48

1.9

326.7

367.7

nmol/l

0.36

(3009542) Hematocrit [Volume Fraction] of Blood

763

1.32

0.46

22.8

14.5

38.3

39.8

0.83

577

(3022948) Iron [Moles/volume] in Serum or Plasma

131

1.36

0.46

1.9

2.1

10.8

13.7

umol/l

0.97

120

(3022313) Gas panel - Capillary blood

1.49

0.44

4.3

6.5

—

(3019225) pH of Specimen

1.44

0.43

2.0

3.5

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.44

0.43

6.9

4.6

1.2

mmol/l

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

2.0

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.41

0.0

3.9

—

(44806118)

0.00

0.40

0.0

2.3

—

(44790049)

0.00

0.40

0.0

2.3

—

(44790047)

0.00

0.40

0.0

2.3

—

(44790048)

0.00

0.40

0.0

2.3

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.45

0.40

2.6

2.5

—

(3045414) Leukocytes [Presence] in Urine

1.41

0.39

1.8

1.7

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.41

0.39

1.2

2.2

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.38

0.38

24.4

7.9

106.2

103.6

mmol/l

1.60

(3027944) Amphetamines [Presence] in Urine

1.49

0.37

1.2

1.3

—

(3020961) Endomysium IgA Ab [Titer] in Serum

1.42

0.36

1.2

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.37

0.33

4.5

3.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

152

0.76

0.32

1.9

1.7

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

111

1.30

0.32

1.6

2.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

139

1.27

0.31

1.2

1.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

122

1.27

0.29

1.9

2.5

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.25

0.28

1.4

1.7

—

(3012516) Albumin [Mass/volume] in Urine

218

1.20

0.27

2.9

3.3

3071.8

102.3

mg/l

0.47

154

(3004789) Transferrin [Mass/volume] in Serum or Plasma

124

1.25

0.25

2.1

2.0

2.4

g/l

0.03

115

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.20

0.25

1.9

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.20

0.22

1.2

1.6

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.21

0.0

1.3

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.21

0.0

3.0

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.3

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.21

0.0

2.3

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.8

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

2.7

—

15.6

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.21

0.0

3.3

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.8

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.8

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.8

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.8

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.21

0.0

1.8

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

2.1

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.20

0.0

2.8

—

107.6

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.20

0.0

2.8

—

3.9

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.20

0.0

2.8

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

100

1.23

0.19

1.8

1.7

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.19

0.16

5.1

7.6

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

180

0.87

0.14

1.6

—

(3026008) Bacteria identified in Urine by Culture

268

1.12

0.14

3.8

2.6

—

(3041096) Erythrocytes [Presence] in Urine by Automated

237

0.91

0.10

4.0

3.6

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

322

1.08

0.10

3.9

4.0

—

(4035726)

1.10

0.08

1.3

1.5

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.84

0.08

1.3

2.2

—

(40761536) Microorganisms panel - Urine sediment

1.10

0.08

6.5

3.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

183

0.91

0.07

2.5

2.0

—

(3013512) EKG study

221

0.94

0.05

2.7

3.7

—

(3003694) ABO and Rh group [Type] in Blood

239

1.06

0.04

1.5

1.6

—

(3029937) Albumin [Presence] in Urine by Test strip

230

1.06

0.04

4.3

3.8

0.0

estimate

—

(40760892) CBC W Ordered Manual Differential panel - Blood

202

0.99

0.00

3.5

5.6

—

(3020682) Albumin/Creatinine [Ratio] in Urine

233

0.98

0.00

3.6

3.9

5.9

17.0

mg/mmol

1.09

157

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

293

0.99

0.00

3.0

3.9

43.5

41.7

ng/l

0.02

201

(3019832) Treponema pallidum Ab [Presence] in Serum

115

0.95

0.00

1.4

1.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

574

0.98

0.00

3.1

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture

0.00

0.0

1.5

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.4

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.1

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3044941) Cell count panel - Synovial fluid

0.00

0.0

1.1

—

(4281824)

0.00

0.0

1.1

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(3006598) pH of Arterial cord blood

0.00

0.0

1.0

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.2

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.2

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

1.4

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.1

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.0

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.0

1.0

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.6

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.93

0.00

2.2

1.7

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

2.8

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3000494) Fungus identified in Specimen by Culture

1.00

0.00

1.4

—

(3006462) Nitrate [Presence] in Urine

0.00

0.0

1.4

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.0

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.4

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

0.0

4.3

—

3.7

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.4

—

(3041008) Bicarbonate [Moles/volume] standard in Arterial cord blood

0.00

0.0

1.0

—

20.6

—

(40761535) Cells panel - Urine sediment

0.97

0.00

1.8

3.8

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.6

—

(44813793)

0.00

0.0

1.0

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.7

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.89

0.00

1.4

2.0

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.1

—

(3035509) Tobramycin [Mass/volume] in Serum or Plasma

0.00

0.0

3.6

—

4.4

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.5

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.1

—

(3045716) Anion gap in Serum or Plasma

0.00

0.0

3.3

—

8.1

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

1.8

—

114.3

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

0.0

4.4

—

58.0

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.1

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.1

—

(4211845)

0.00

0.0

1.3

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.0

—

(3021788) Differential panel - Synovial fluid

0.00

0.0

1.3

—

(3029536) Hepatitis C virus RNA [Units/volume] (viral load) in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3003932) Carbon dioxide [Partial pressure] in Arterial cord blood

0.00

0.0

1.0

—

7.1

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.0

2.5

—

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

0.0

6.1

—

99.7

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.4

—

(3021706) Oxygen [Partial pressure] in Arterial cord blood

0.00

0.0

1.0

—

3.3

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3032567) Hepatitis B virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

0.0

1.2

—

(4146454)

0.00

0.0

3.8

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.0

1.0

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

22.1

—

(40768446) Kidney Pathology biopsy report

0.00

0.0

1.8

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

1.3

—

(3000012) Reticulocyte production index

0.00

0.0

1.4

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_HETEROTRONAS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_HETEROTRONAS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: H7_HETEROTRONAS – Other and unspecified heterotropia

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other and unspecified heterotropia

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints