Haemophilus septicemia

HAEMOPHIL_SEPTICHE

Pasteurella hemorrhagic septicemia: Any of several bacterial diseases, usually caused by pasteurella multocida, marked by the presence of hemorrhagic areas in the subcutaneous tissues, serous membranes, muscles, lymph glands, and throughout the internal organs. The diseases primarily affect animals and rarely humans.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — A41.3 Hospital discharge: ICD-9 — 0384A Cause of death: ICD-10 — A41.3 Cause of death: ICD-9 — 0384A 2 out of 7 registries used, show all original rules.	67
4. Check minimum number of events None	67
5. Include endpoints None	67
6. Filter based on genotype QC (FinnGen only)	67

Control definitions (FinnGen only)

Control exclude: ASTHMA_SEPTICHE_PNEUMONIA

Extra metadata

First used in FinnGen datafreeze: DF2
Parent code in ICD-10: A41
Name in latin: Septic(h)aemia ab Haemophilo influenzae

NAME	HAEMOPHIL_SEPTICHE
CONTROL_EXCLUDE	ASTHMA_SEPTICHE_PNEUMONIA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	A413
HD_ICD_9	0384A
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	A413
COD_ICD_9	0384A
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Haemophilus septicemia based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	634	322	306
Only index persons	485	264	221
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	61.69	65.59	57.45
Only index persons	60.23	65.06	54.47

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	67	33	34
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	56.68	52.54	60.69

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
62: Matched controls
619

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

A41.3

ICD-10 Finland

Sepsis due to Haemophilus influenzae

+∞

65.8

0384A

ICD-9 Finland

Septicaemia due to other gram-negative organisms[SEPTICHAEMIA HAEMOPHILUS INFLUENZAE]

+∞

11.8

J14

ICD-10 Finland

Pneumonia due to Haemophilus influenzae

+∞

10.7

A41.9

ICD-10 Finland

Sepsis, unspecified

13.5

8.3

J18.9

ICD-10 Finland

Pneumonia, unspecified

4.9

7.6

J01MA12

ATC

levofloxacin; systemic

4.7

6.4

J01FF01

ATC

clindamycin; systemic

4.3

6.2

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3023368) Bacteria identified in Blood by Culture

138

5.37

10.75

8.8

4.0

—

(3012544) pH of Venous blood

4.76

6.61

16.7

5.8

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

4.67

5.62

3.1

1.6

—

(3007853) Bacteria identified in Skin by Aerobe culture

3.81

4.56

3.1

1.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.66

4.51

3.5

1.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

3.23

4.45

2.5

1.9

—

(40758558) Short blood count panel - Blood

130

2.98

4.39

10.5

6.9

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

3.65

4.31

1.9

1.8

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.39

4.05

3.6

1.6

—

(3052851) Hemolysis interference index of Serum or Plasma

6.74

3.96

2.3

3.7

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

203

2.67

3.79

5.4

2.4

155.4

116.9

ug/l

0.51

187

(3042936) Bacteria identified in Isolate by Culture

3.15

3.76

3.9

1.6

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

8.52

3.65

1.4

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

10.81

3.57

1.2

1.5

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

6.95

3.27

1.9

1.0

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

6.95

3.27

1.9

1.0

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.78

3.27

3.3

1.7

—

(42870588) Differential panel, method unspecified - Blood

165

2.48

3.20

15.3

5.3

—

(3004588) Protein electrophoresis panel - Serum or Plasma

3.88

3.18

4.7

2.5

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

252

2.46

3.16

22.8

6.4

1.2

mmol/l

1.00

214

(3000991) Gas panel - Venous blood

3.27

3.12

24.6

6.6

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

10.65

3.02

1.6

2.0

—

(3024928) Oxygen saturation in Venous blood

7.19

2.93

8.0

11.6

—

(3026782) Osmolality of Urine

102

2.54

2.86

4.4

2.5

482.5

520.6

mosm/kgh2o

0.44

(3007164) IgA [Mass/volume] in Serum or Plasma

103

2.51

2.80

2.0

1.4

2.4

2.3

g/l

0.10

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.69

2.66

2.1

1.7

—

(36304419) Bacteria [Presence] in Urine

136

2.34

2.65

8.4

2.6

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

5.87

2.60

3.3

1.2

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.83

2.59

3.1

1.3

—

(1761868) Lipid panel - Serum or Plasma

177

0.33

2.54

3.0

—

(3022948) Iron [Moles/volume] in Serum or Plasma

2.51

2.44

7.4

2.1

10.8

14.7

umol/l

1.32

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

5.90

2.25

3.2

1.3

—

(3001604) Monocytes [#/volume] in Blood

249

2.09

2.24

13.6

5.1

0.7

0.6

e9/l

0.67

222

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

3.99

2.21

1.0

1.1

—

(3006315) Basophils [#/volume] in Blood

251

2.06

2.17

13.6

5.1

0.0

e9/l

0.67

224

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

181

2.06

2.12

7.4

2.7

—

(3032080) INR in Blood by Coagulation assay

226

2.02

2.09

8.5

7.2

1.3

inr

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

219

2.00

2.02

14.8

4.4

31.5

35.3

g/l

2.85

209

(3019198) Lymphocytes [#/volume] in Blood

257

1.98

13.6

5.1

1.9

1.8

e9/l

0.22

229

(3034770) Mitochondria Ab [Titer] in Serum

4.81

1.97

1.0

1.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

185

2.00

1.97

2.6

1.9

91.2

97.0

pmol/l

0.32

(3011397) Hemoglobin [Presence] in Urine by Test strip

120

2.09

1.91

5.0

3.8

—

(3026008) Bacteria identified in Urine by Culture

170

1.99

1.89

4.4

3.1

—

(3013115) Eosinophils [#/volume] in Blood

262

1.92

1.82

15.1

5.4

0.2

e9/l

0.25

233

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

2.44

1.80

6.5

2.3

20.1

27.4

u/l

0.86

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

3.55

1.79

1.7

1.2

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

3.55

1.79

1.7

1.2

—

(3018095) Leukocytes [#/volume] in Urine

191

1.91

1.76

9.8

3.3

20.8

62.7

e6/l

0.94

127

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.79

1.72

44.3

8.2

26.7

24.5

mmol/l

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

3.36

1.70

1.3

1.8

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.77

1.64

2.4

1.6

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.88

1.63

8.7

6.1

0.9

1.5

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

279

1.84

1.61

12.3

5.8

10.5

13.4

umol/l

0.95

264

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.61

1.59

1.8

1.7

—

(3044640) Blood type and Crossmatch panel - Blood

171

1.85

1.55

3.7

2.0

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

3.51

1.55

1.4

1.1

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

3.51

1.55

7.4

5.5

252.2

187.9

—

(3019060) Gas panel - Arterial blood

2.65

1.55

8.8

4.6

—

(3021960) Folate [Moles/volume] in Serum or Plasma

121

1.93

1.53

2.3

1.5

18.8

21.2

nmol/l

0.32

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

3.29

1.46

10.0

1.9

19.4

30.9

u/ml

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

3.29

1.46

1.4

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

1.38

0.0

1.8

—

(3021589) Normoblasts [#/volume] in Blood

213

1.74

1.36

22.4

9.7

0.0

e9/l

0.47

179

(3014007) Fractional oxyhemoglobin in Arterial blood

2.25

1.23

11.3

7.6

92.5

92.7

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

113

1.81

1.22

3.9

1.9

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.62

1.17

7.6

3.3

—

(3019832) Treponema pallidum Ab [Presence] in Serum

2.13

1.16

1.8

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

1.89

1.16

8.6

3.1

0.8

mmol/l

0.54

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.03

1.15

6.1

3.2

—

(3015736) pH of Urine

203

1.65

1.14

4.7

3.8

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.37

1.05

2.8

1.8

—

(36660697) Celiac disease serology panel - Serum

2.05

1.00

1.4

1.1

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.05

1.00

1.4

1.3

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

1.00

0.0

1.5

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

0.00

0.99

0.0

1.2

—

147.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

345

1.58

0.98

9.8

4.5

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

326

1.56

0.96

10.9

4.7

7.0

6.6

mmol/l

0.52

307

(3022217) INR in Platelet poor plasma by Coagulation assay

1.81

0.92

38.6

29.5

—

1.6

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

1.73

0.86

10.8

2.7

8.4

5.0

e6/l

—

(3002385) Erythrocyte distribution width [Ratio]

426

1.56

0.81

54.0

16.6

14.7

13.8

2.46

417

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

1.90

0.81

2.0

2.3

—

(1002224) Polysomnography panel

0.00

0.81

0.0

1.1

—

(3002256) Pathology report gross observation

1.78

0.77

1.5

1.4

—

(3025941) Bacteria identified in Stool by Culture

1.94

0.76

1.3

1.2

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

1.66

0.76

10.8

2.5

0.9

1.0

e6/l

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.92

0.70

16.8

8.1

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

161

1.44

0.62

3.6

3.1

2215.6

1184.1

ng/l

0.59

132

(3027944) Amphetamines [Presence] in Urine

0.00

0.61

0.0

1.3

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

1.55

0.60

2.4

4.5

3.2

24.3

ug/l

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

247

1.39

0.60

7.2

3.8

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

387

1.40

0.58

20.6

6.9

99.5

80.2

u/l

1.12

361

(3000494) Fungus identified in Specimen by Culture

1.52

0.56

2.3

1.3

—

(3035941) MCH [Entitic mass]

569

0.67

0.55

61.5

20.0

29.8

30.2

0.71

562

(3010813) Leukocytes [#/volume] in Blood

569

0.67

0.55

61.7

20.2

8.3

6.7

e9/l

2.16

551

(3026361) Erythrocytes [#/volume] in Blood

569

0.67

0.55

61.6

20.1

4.2

4.5

e12/l

3.82

551

(3000963) Hemoglobin [Mass/volume] in Blood

569

0.67

0.55

61.8

20.3

122.2

135.4

g/l

6.53

561

(3024731) MCV [Entitic volume]

568

0.68

0.52

61.6

20.1

90.8

90.6

0.08

561

(3007461) Platelets [#/volume] in Blood

568

0.68

0.52

61.6

20.2

258.2

247.0

e9/l

0.41

555

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.58

0.50

1.9

2.1

—

(3000492) Spirometry study

1.45

0.46

1.1

1.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

327

1.29

0.42

4.0

3.2

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.42

0.0

1.5

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.42

0.0

1.5

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.40

0.0

1.3

—

(3027008) Opiates [Presence] in Urine

0.00

0.40

0.0

1.3

—

(3016879) Cocaine [Presence] in Urine

0.00

0.40

0.0

1.3

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.40

0.0

1.3

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.40

0.0

1.2

—

(4035726)

1.42

0.33

2.1

1.3

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.42

0.33

2.6

2.3

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

201

1.22

0.26

3.5

3.9

59.6

32.8

ng/l

0.48

144

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

458

0.83

0.24

4.6

1.9

mu/l

0.03

417

(3041096) Erythrocytes [Presence] in Urine by Automated

145

0.79

0.24

4.0

3.8

—

(3013512) EKG study

145

0.79

0.24

4.7

3.7

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.21

0.0

1.7

—

2.1

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.21

0.0

1.5

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

(3011288) Drugs identified in Urine by Screen method

0.00

0.21

0.0

1.3

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.21

0.0

1.5

—

(4094501)

0.00

0.20

0.0

1.0

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.20

0.0

1.5

—

33.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

110

1.23

0.19

10.5

4.5

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

520

0.85

0.16

58.0

16.0

138.7

139.6

mmol/l

2.15

510

(3020564) Creatinine [Moles/volume] in Serum or Plasma

538

0.85

0.15

49.4

15.8

98.6

77.3

umol/l

1.45

538

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

547

0.85

0.14

22.6

9.8

22.4

25.9

u/l

1.49

529

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.07

0.09

2.4

2.9

4.3

5.7

ug/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.07

0.09

1.4

1.6

—

(40768797) Stomach Pathology biopsy report

1.08

0.09

1.2

1.4

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

0.78

0.08

3.8

2.2

1635.2

443.4

nmol/l

—

(3009542) Hematocrit [Volume Fraction] of Blood

474

0.91

0.08

56.0

14.9

37.1

40.0

1.36

355

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.05

0.07

1.7

1.6

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

104

0.84

0.07

1.6

1.7

518.3

448.7

pmol/l

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

369

1.07

0.05

3.4

4.1

14.7

pmol/l

0.02

339

(40761511) CBC panel - Blood by Automated count

539

0.92

0.04

36.1

13.1

—

(3003694) ABO and Rh group [Type] in Blood

149

0.92

0.04

1.6

1.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

201

1.07

0.03

3.8

4.2

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

122

1.08

0.03

2.2

1.9

1.5

1.4

mmol/l

0.29

101

(3044889) 12 lead EKG panel

357

0.96

0.01

5.1

3.8

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

474

1.04

0.00

37.8

12.3

76.4

80.6

ml/min/173m2

0.47

393

(40768804) Tissue Pathology biopsy report

196

1.03

0.00

3.5

2.2

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.0

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.4

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.0

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

1.3

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

16.0

—

(3048689) Calprotectin [Mass/mass] in Stool

0.90

0.00

4.8

1.8

61.3

111.3

ug/g

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

68.4

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

3.1

—

4.2

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.2

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

2.3

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

2.6

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

3.7

—

17.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.85

0.00

22.2

9.1

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.2

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.3

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.0

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.0

1.3

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

1.3

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

0.0

1.7

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

246.0

—

(3000034) Microalbumin [Mass/volume] in Urine

0.00

0.0

4.4

—

30.5

—

Mortality – FinRegistry

↥

Association

Association between endpoint HAEMOPHIL_SEPTICHE and mortality.

Females

Parameter	HR [95% CI]	p-value
HAEMOPHIL_SEPTICHE	3.291 [1.69, 6.41]	< 0.001
Birth year	0.999 [0.99, 1.01]	0.79

During the follow-up period (1.1.1998 — 31.12.2019), 77 out of 192 females with HAEMOPHIL_SEPTICHE died.

Males

Parameter	HR [95% CI]	p-value
HAEMOPHIL_SEPTICHE	3.733 [1.8, 7.73]	< 0.001
Birth year	0.984 [0.97, 0.99]	0.001

During the follow-up period (1.1.1998 — 31.12.2019), 77 out of 182 males with HAEMOPHIL_SEPTICHE died.

Mortality risk

Mortality risk for people of age

years, who have HAEMOPHIL_SEPTICHE.

N-year risk	Females	Males
1	0.445%	0.698%
5	2.386%	3.852%
10	5.776%	9.398%
15	10.766%	17.086%
20	18.101%	28.376%

Relationships between endpoints

↥

Index endpoint: HAEMOPHIL_SEPTICHE – Haemophilus septicemia

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Haemophilus septicemia

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints