Phlebitis and thrombophlebitis of superficial vessels of lower extremities, drug-induced

PHLEBI_THROMBOP_SUPERF_VESSE_LOWER_EXTREMITI

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ATC codes for adverse effects of Drugs ANY
  • Hospital discharge: ICD-10 I80.0#

1 out of 7 registries used, show all original rules.

104

4. Check minimum number of events

None

104

5. Include endpoints

None

104

6. Filter based on genotype QC (FinnGen only)

104

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5

Similar endpoints

List of similar endpoints to Phlebitis and thrombophlebitis of superficial vessels of lower extremities, drug-induced based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

None

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (not available in FinRegistry).

-FinnGen-

Key figures

All Female Male
Number of individuals 104 68 36
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 54.24 53.57 55.52

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
98
Matched controls
980
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I80.0
ICD-10 Finland
Phlebitis and thrombophlebitis of superficial vessels of lower extremities
+∞
122.1
98
16
I83.9
ICD-10 Finland
Varicose veins of lower extremities without ulcer or inflammation
6.4
11.0
31
66
I80.3
ICD-10 Finland
Phlebitis and thrombophlebitis of lower extremities, unspecified
11.2
9.2
17
18
B01AA03
ATC
warfarin; systemic
3.9
8.5
43
164
PHD99
NOMESCO Finland
Resection of other vein
6.7
7.9
20
36
PHD76
NOMESCO Finland
Resection of long saphenous vein
7.4
7.0
16
25

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
35
187
2.31
3.71
1.5
1.8
1.7
1.4
mg/l
0.15
25
157
47
284
2.19
3.70
3.8
3.2
29.1
41.3
e6/l
0.37
42
218
34
182
2.29
3.57
3.4
3.1
547.7
535.9
mosm/kgh2o
0.11
29
154
51
329
2.08
3.31
4.7
3.7
107.2
58.2
e6/l
0.56
40
233
42
255
2.09
3.17
4.3
3.1
1.1
0.4
e6/l
0.49
36
188
41
248
2.08
3.12
4.4
3.0
—
—
—
0
0
7
20
3.67
2.09
1.9
1.5
—
—
—
0
0
49
351
1.75
2.05
9.7
10.4
0.0
0.0
e9/l
0.71
36
288
31
199
1.79
1.86
2.6
2.1
2.5
3.1
mg/l
0.81
25
170
50
370
1.68
1.80
21.9
8.0
1.3
1.2
inr
0.17
13
96
64
761
0.59
1.79
3.7
4.2
1.2
1.3
mmol/l
0.45
59
672
42
298
1.69
1.77
4.6
3.6
—
—
—
0
0
68
794
0.59
1.73
4.2
4.6
1.5
1.5
mmol/l
0.29
62
710
48
358
1.63
1.64
4.8
5.4
0.7
0.6
%
0.31
42
331
12
57
2.25
1.62
1.2
2.9
11.8
9.6
g/l
0.36
12
49
50
379
1.61
1.59
4.8
5.6
27.2
26.7
%
0.12
45
349
14
72
2.09
1.57
3.4
8.7
—
—
—
0
0
13
65
2.14
1.56
3.3
3.2
68.6
66.1
g/l
0.60
13
58
21
126
1.84
1.55
47.8
27.0
—
1.3
—
0
20
7
27
2.70
1.54
4.0
4.0
—
—
—
0
0
40
292
1.60
1.46
3.8
4.2
7.4
7.4
ph
—
8
51
27
178
1.70
1.46
4.9
3.4
3906.0
100.5
ng/l
0.47
22
154
36
258
1.60
1.41
4.4
5.2
—
—
—
0
0
48
369
1.56
1.39
4.9
5.7
9.0
8.6
%
0.39
43
344
70
799
0.62
1.39
4.4
4.7
4.5
4.6
mmol/l
0.41
65
721
48
370
1.55
1.37
4.9
5.4
3.3
2.6
%
1.05
43
345
52
411
1.53
1.31
5.6
5.5
1.8
1.8
e9/l
0.12
38
363
48
373
1.53
1.31
4.9
5.2
58.0
58.5
%
0.11
42
347
67
768
0.64
1.29
6.6
6.3
40.9
40.8
mmol/mol
0.02
62
707
18
276
0.58
1.28
5.5
3.9
—
—
—
0
0
34
248
1.55
1.22
4.9
4.6
—
—
—
0
0
5
20
2.57
1.16
1.2
1.3
—
—
—
0
0
8
40
2.08
1.15
1.1
1.2
—
—
—
0
0
13
74
1.86
1.13
1.6
2.5
0.2
0.2
g/l
0.07
13
67
27
190
1.57
1.12
4.2
4.2
—
—
—
0
0
50
403
1.46
1.10
5.5
5.4
0.7
0.6
e9/l
0.91
34
346
72
804
0.66
1.08
5.3
5.0
5.9
6.0
mmol/l
0.26
66
727
50
405
1.45
1.06
5.5
5.4
0.0
0.0
e9/l
0.30
34
349
5
22
2.33
1.04
1.8
3.6
5.2
4.9
kpa
—
5
22
5
22
2.33
1.04
1.8
3.6
8.5
8.3
kpa
—
5
22
7
35
2.07
1.02
3.3
2.4
—
—
—
0
0
75
660
1.49
1.00
25.7
19.3
14.0
13.9
%
0.03
75
645
81
880
0.64
1.00
29.0
23.2
30.4
30.4
pg
0.05
81
864
81
880
0.64
1.00
29.3
23.5
130.3
133.0
g/l
0.99
81
863
21
143
1.59
1.00
1.1
1.5
2.4
2.5
g/l
0.09
12
78
51
419
1.43
0.98
5.5
5.6
0.2
0.2
e9/l
1.49
38
370
81
879
0.65
0.97
29.0
23.3
92.0
91.7
fl
0.28
81
863
9
51
1.84
0.97
3.4
7.7
25.7
25.8
mmol/l
—
9
51
11
65
1.77
0.86
3.5
2.9
—
—
—
0
0
30
229
1.44
0.84
1.4
1.6
1.1
1.3
mmol/l
0.79
25
183
6
32
1.93
0.83
1.0
1.2
—
—
—
0
0
77
836
0.70
0.80
18.7
14.6
—
—
—
0
0
0
27
0.00
0.78
0.0
1.9
—
25.0
—
0
20
16
109
1.55
0.76
1.4
1.3
—
—
—
0
0
10
61
1.71
0.71
1.8
1.5
—
—
—
0
0
5
27
1.89
0.69
33.4
15.1
—
—
—
0
0
5
27
1.89
0.69
1.2
1.1
—
—
—
0
0
45
379
1.33
0.69
2.6
1.9
90.0
95.4
pmol/l
0.28
24
184
15
208
0.67
0.67
1.3
1.3
—
—
—
0
0
80
856
0.72
0.66
24.1
18.9
75.8
77.7
umol/l
0.35
80
856
80
854
0.73
0.62
24.7
18.8
3.9
4.0
mmol/l
0.67
80
830
0
20
0.00
0.61
0.0
1.9
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
6
37
1.66
0.56
1.0
1.2
—
—
—
0
0
80
851
0.74
0.56
24.3
18.8
140.0
139.7
mmol/l
0.52
80
826
12
83
1.50
0.54
4.2
3.0
—
—
—
0
0
13
93
1.45
0.51
1.6
1.7
—
—
—
0
0
7
46
1.56
0.49
5.0
4.5
—
—
—
0
0
10
68
1.52
0.49
1.6
3.7
56.3
75.3
e9/l
—
5
53
5
82
0.59
0.48
8.8
3.2
—
—
—
0
0
47
416
1.24
0.45
6.0
5.7
0.0
0.0
estimate
—
9
72
37
319
1.25
0.45
4.4
4.2
—
—
—
0
0
5
32
1.59
0.43
2.4
1.8
—
—
—
0
0
15
115
1.36
0.41
1.1
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
28.9
—
0
10
0
19
0.00
0.39
0.0
6.6
—
—
—
0
0
47
421
1.21
0.39
4.5
4.3
0.0
0.0
estimate
—
9
73
9
69
1.33
0.38
2.8
4.3
—
—
—
0
0
46
412
1.21
0.38
4.6
4.3
0.0
0.0
estimate
—
9
77
11
81
1.40
0.38
1.1
1.2
—
—
—
0
0
63
582
1.21
0.37
5.7
4.7
—
—
—
0
0
6
45
1.35
0.34
1.0
1.1
—
—
—
0
0
6
46
1.32
0.33
2.3
2.3
—
—
—
0
0
64
596
1.19
0.33
4.5
4.1
—
—
—
0
0
22
258
0.81
0.32
3.6
3.2
—
—
—
0
0
26
230
1.17
0.23
2.8
7.0
—
—
—
0
0
67
702
0.87
0.22
24.5
16.5
38.9
39.1
%
0.07
52
474
20
228
0.85
0.21
5.6
4.7
0.0
0.0
estimate
—
9
75
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
5.0
—
—
—
0
0
51
478
1.13
0.21
6.8
9.3
4.2
4.2
e9/l
0.07
36
421
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
16
137
1.20
0.20
2.2
1.7
35.8
29.9
s
0.80
16
130
79
816
0.87
0.19
21.9
16.0
23.3
25.8
mg/l
0.39
73
649
5
66
0.75
0.17
7.0
5.3
23.2
24.7
mmol/l
—
5
61
13
111
1.20
0.16
3.5
7.1
4.8
5.1
kpa
0.70
13
104
13
111
1.20
0.16
3.5
7.1
13.6
11.7
kpa
0.34
13
104
6
76
0.78
0.16
1.0
1.5
—
—
—
0
0
10
83
1.23
0.16
1.3
1.9
342.4
365.8
nmol/l
—
10
74
15
170
0.86
0.15
7.1
5.1
—
—
—
0
0
33
311
1.09
0.11
2.7
3.3
2.4
2.3
mmol/l
0.02
28
279
11
125
0.87
0.11
2.6
3.0
0.8
1.0
ug/l
—
6
90
5
45
1.12
0.10
1.2
1.4
—
—
—
0
0
74
757
0.92
0.09
6.1
4.9
1.8
1.9
mu/l
0.69
69
671
24
256
0.92
0.09
3.3
2.9
15.5
536.2
mg/l
0.83
15
161
63
615
1.06
0.07
4.4
4.1
15.1
15.0
pmol/l
0.10
58
543
26
274
0.93
0.07
4.2
3.6
2.9
5.0
mg/mmol
0.58
17
159
9
101
0.88
0.06
4.7
7.4
98.3
95.8
%
—
9
96
9
104
0.85
0.06
1.4
1.4
—
—
—
0
0
11
121
0.90
0.06
2.8
2.0
—
—
—
0
0
24
230
1.06
0.04
3.5
4.0
—
—
—
0
0
29
280
1.05
0.03
1.8
2.1
118.0
202.3
u/l
2.15
29
265
36
350
1.04
0.03
2.4
2.2
—
—
—
0
0
11
104
1.06
0.01
1.5
3.5
1.6
1.9
%
0.75
11
94
35
344
1.03
0.00
4.9
4.2
24.7
49.9
ng/l
1.20
26
266
28
281
1.00
0.00
2.8
2.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
1.9
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
0.00
3.3
3.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
12.1
—
0
5
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
6.4
—
43.3
—
0
5
9
89
1.01
0.00
1.4
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
371.0
—
0
8
5
59
0.84
0.00
3.2
2.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
245.5
—
0
6
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
6.6
—
0
5
7
69
1.02
0.00
1.1
1.5
—
—
—
0
0
6
59
1.02
0.00
1.2
1.2
—
—
—
0
0
7
74
0.94
0.00
1.1
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (not available in FinRegistry).

Relationships between endpoints

Index endpoint: PHLEBI_THROMBOP_SUPERF_VESSE_LOWER_EXTREMITI – Phlebitis and thrombophlebitis of superficial vessels of lower extremities, drug-induced

GWS hits: -

This endpoint is excluded (not available in FinRegistry).