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Problems related to education and literacy

Z21_PROBL_RELATED_EDUCATION_LITER

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 Z55
  • Cause of death: ICD-10 Z55

2 out of 7 registries used, show all original rules.

94

4. Check minimum number of events

None

94

5. Include endpoints

None

94

6. Filter based on genotype QC (FinnGen only)

85

Control definitions (FinnGen only)

Control exclude
Z21_PERSONS_W_POTEN_HEALTH_HAZARDS_RELATED_SOCIO_PSYCHOSO_CIRCUMSTANC

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Z5[5-9]|Z6

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 85 46 39
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 15.35 15.47 15.20

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
94
Matched controls
940
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Z55.4
ICD-10 Finland
Educational maladjustment and discord with teachers and classmates
+∞
34.5
31
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
7.6
21.2
44
98
Z55.9
ICD-10 Finland
Problem related to education and literacy, unspecified
204.9
17.1
17
*
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
6.1
17.0
44
118
Z55.8
ICD-10 Finland
Other problems related to education and literacy
+∞
16.1
15
*
N06AB03
ATC
fluoxetine; oral
7.6
14.9
25
43
Z55.3
ICD-10 Finland
Underachievement in school
+∞
13.9
13
*
ZY010
NOMESCO Finland
Hospital outpatient
7.7
13.1
21
34
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
5.4
11.6
28
68
N05AH04
ATC
quetiapine; oral
4.6
11.5
40
131
Z55.0
ICD-10 Finland
Illiteracy and low-level literacy
+∞
10.6
10
*
P76
ICPC
Depressive disorder
5.3
9.5
22
51
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
5.6
8.5
18
38
Z2446
NOMESCO Finland
Social worker
7.4
8.4
20
33
N05AX12
ATC
aripiprazole; systemic
5.3
8.3
19
43
N06AB06
ATC
sertraline; oral
4.2
8.1
26
78
F93.89
ICD-10 Finland
Other childhood emotional disorders
16.9
8.0
12
8
EBA05
NOMESCO Finland
Complicated extraction of tooth
3.7
7.8
32
114
N06AB04
ATC
citalopram; systemic
4.3
7.7
24
70
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
8.1
7.4
16
23
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
9.9
6.8
13
15
P19
ICPC
Drug abuse
24.6
6.8
9
*
F92.0
ICD-10 Finland
Depressive conduct disorder
74.7
6.5
7
*
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
8.7
6.4
13
17
N06AB10
ATC
escitalopram; oral
3.1
6.4
39
176
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
4.5
6.3
17
44
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
6.0
6.0
16
31

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
19
36
6.36
10.12
3.4
1.9
—
—
—
0
0
21
60
4.22
6.91
9.7
1.6
—
—
—
0
0
21
78
3.18
4.63
3.4
1.6
—
—
—
0
0
8
10
8.61
4.15
2.1
2.8
—
—
—
0
0
35
184
2.44
3.95
2.7
4.6
36.71
38.20
g/l
0.50
30
174
10
20
5.46
3.81
28.1
16.0
94.32
94.37
%
—
10
20
10
20
5.46
3.81
28.1
16.1
0.87
0.76
%
—
10
20
10
20
5.46
3.81
27.8
16.1
1.64
1.65
%
—
10
20
9
17
5.73
3.61
1.3
1.1
—
—
—
0
0
24
110
2.59
3.57
3.5
4.1
—
—
—
0
0
50
320
2.20
3.46
5.9
5.9
—
—
—
0
0
22
102
2.51
3.18
3.4
1.5
—
—
—
0
0
22
103
2.48
3.11
3.4
1.5
—
—
—
0
0
7
12
6.20
3.08
12.4
2.1
1.74
1.19
mmol/l
—
7
12
21
102
2.36
2.73
3.5
1.5
—
—
—
0
0
20
95
2.40
2.73
3.6
1.5
—
—
—
0
0
38
238
2.00
2.62
8.7
7.5
1.20
1.22
mmol/l
0.92
32
198
6
11
5.74
2.58
14.2
2.2
3.90
3.83
mmol/l
—
6
11
10
32
3.37
2.52
27.9
12.9
—
—
—
0
0
50
350
1.92
2.45
6.9
5.9
0.17
0.16
e9/l
0.17
41
313
53
382
1.89
2.34
2.9
2.5
—
—
—
0
0
11
41
2.90
2.30
32.4
9.7
103.18
104.68
mmol/l
0.42
11
41
8
24
3.54
2.23
10.9
22.0
—
—
—
0
0
48
339
1.85
2.23
5.9
5.3
0.03
0.04
e9/l
0.32
40
297
6
14
4.50
2.18
1.0
1.6
—
—
—
0
0
85
744
2.49
2.18
14.4
9.1
26.62
20.89
mg/l
0.70
66
552
19
100
2.13
2.04
3.8
1.6
—
—
—
0
0
47
337
1.79
2.02
6.1
5.3
0.56
0.54
e9/l
0.29
40
297
24
139
1.98
2.00
2.1
1.9
329.61
88.07
ug/g
0.95
18
107
6
16
3.93
1.97
24.7
4.6
—
—
—
0
0
11
46
2.58
1.93
1.2
1.2
—
—
—
0
0
12
53
2.45
1.90
1.9
1.2
—
—
—
0
0
53
400
1.75
1.87
9.4
8.0
4.40
4.07
e9/l
0.45
45
352
5
134
0.34
1.79
1.0
1.3
—
—
—
0
0
49
365
1.72
1.78
6.0
5.2
1.99
1.93
e9/l
0.24
40
328
75
631
1.93
1.78
3.3
2.8
5.52
5.48
mmol/l
0.14
70
576
6
18
3.49
1.77
1.0
1.2
307.67
331.28
mg/l
—
6
18
43
311
1.71
1.73
6.3
6.9
0.00
0.00
e9/l
0.49
34
253
32
213
1.76
1.72
1.7
1.4
1.67
2.02
g/l
1.13
20
144
13
65
2.16
1.57
1.7
1.4
371.08
417.27
nmol/l
0.35
13
56
6
23
2.71
1.39
1.3
1.3
—
—
—
0
0
20
123
1.80
1.38
1.3
1.3
4.77
6.64
u/ml
—
9
51
9
42
2.26
1.38
1.1
1.1
—
—
—
0
0
5
17
3.05
1.37
14.0
3.9
0.68
0.78
%
—
5
17
6
24
2.60
1.32
1.0
1.1
—
—
—
0
0
5
18
2.87
1.30
1.0
1.5
11.20
78.44
e6/l
—
5
18
6
25
2.49
1.26
19.7
5.6
25.08
25.94
mmol/l
—
6
25
26
177
1.65
1.26
3.8
2.7
1.02
1.02
kg/l
—
6
21
9
162
0.51
1.23
1.6
1.6
—
—
—
0
0
28
196
1.61
1.22
2.8
2.4
99.78
56.52
u/l
0.45
23
183
47
371
1.53
1.21
3.6
3.0
0.00
0.00
estimate
—
9
80
46
363
1.52
1.18
3.6
3.0
0.00
0.00
estimate
—
9
88
26
180
1.61
1.18
1.5
1.5
82.49
93.66
pmol/l
1.17
14
99
46
364
1.52
1.16
4.8
3.9
0.00
0.00
estimate
—
9
85
44
345
1.52
1.16
5.8
5.3
31.73
29.70
%
0.48
39
329
5
21
2.46
1.10
14.0
4.4
129.60
138.38
g/l
—
5
21
5
21
2.46
1.10
2.0
2.0
—
—
—
0
0
30
219
1.54
1.08
3.6
3.3
0.00
0.01
estimate
—
9
82
27
193
1.56
1.07
12.9
5.8
1.04
1.07
inr
—
9
66
21
292
0.64
0.99
2.7
1.7
—
—
—
0
0
22
153
1.57
0.97
4.5
6.3
—
—
—
0
0
18
258
0.63
0.97
1.9
1.9
—
—
—
0
0
25
180
1.53
0.95
3.4
2.1
—
—
—
0
0
6
27
2.30
0.95
1.2
1.4
—
—
—
0
0
8
42
1.99
0.91
3.8
4.1
—
—
—
0
0
6
30
2.07
0.88
2.2
1.2
—
—
—
0
0
54
460
1.41
0.85
4.2
3.7
—
24.00
—
0
8
17
115
1.58
0.84
2.0
2.5
—
—
—
0
0
42
343
1.41
0.84
5.7
5.0
54.73
56.32
%
0.29
36
327
24
178
1.47
0.79
1.9
2.4
18.84
50.56
e6/l
0.81
18
138
28
215
1.43
0.78
2.7
2.9
13.30
59.63
e6/l
1.10
20
148
5
23
2.24
0.77
2.0
1.7
—
—
—
0
0
30
235
1.41
0.74
3.1
2.5
—
—
—
0
0
23
174
1.43
0.69
1.6
1.5
—
—
—
0
0
11
70
1.65
0.68
1.5
2.7
—
—
—
0
0
7
44
1.64
0.66
5.6
2.0
—
—
—
0
0
5
29
1.76
0.64
1.2
1.4
22.00
34.03
nmol/l
—
5
29
18
132
1.45
0.63
2.8
1.6
0.78
0.68
mg/l
0.16
13
92
19
142
1.42
0.60
3.5
3.2
—
—
—
0
0
12
81
1.55
0.60
3.7
3.0
24.40
122.82
ng/l
—
5
44
8
54
1.53
0.59
1.0
1.1
—
—
—
0
0
16
213
0.70
0.58
2.4
1.9
—
—
—
0
0
30
246
1.32
0.55
1.4
1.3
0.38
1.05
u/ml
—
9
65
6
39
1.57
0.54
2.0
1.3
—
—
—
0
0
22
273
0.75
0.52
1.4
1.8
—
—
—
0
0
11
79
1.44
0.43
1.5
1.2
—
—
—
0
0
8
60
1.36
0.41
1.1
1.8
—
—
—
0
0
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.9
—
—
—
0
0
0
19
0.00
0.39
0.0
2.9
—
—
—
0
0
20
241
0.78
0.38
2.1
1.7
—
—
—
0
0
20
167
1.25
0.32
1.7
2.4
—
—
—
0
0
20
168
1.24
0.30
6.0
2.9
14.05
17.61
ng/l
0.35
13
73
9
76
1.20
0.25
1.9
2.0
12.72
15.01
umol/l
—
9
68
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
3.0
—
—
—
0
0
6
49
1.24
0.20
1.5
1.5
2.55
1.68
%
—
6
43
6
49
1.24
0.20
3.8
3.6
5.09
4.56
pmol/l
—
6
44
8
72
1.12
0.16
1.3
1.2
—
—
—
0
0
10
83
1.23
0.16
1.0
1.1
—
—
—
0
0
69
669
1.12
0.13
3.1
2.8
2.86
2.80
mmol/l
0.17
60
638
82
806
1.14
0.09
14.2
8.4
—
—
—
0
0
6
53
1.14
0.09
1.5
1.4
—
—
—
0
0
7
68
1.03
0.08
1.3
1.4
—
—
—
0
0
9
85
1.07
0.07
2.2
3.2
—
—
—
0
0
29
302
0.94
0.05
1.8
1.7
—
—
—
0
0
11
101
1.10
0.04
1.5
1.5
—
—
—
0
0
64
630
1.05
0.03
2.6
2.7
1.43
1.23
mmol/l
0.89
57
605
67
664
1.03
0.00
2.9
2.7
1.28
1.42
mmol/l
2.17
59
634
10
102
0.98
0.00
1.6
2.2
—
—
—
0
0
67
668
1.01
0.00
3.1
2.8
4.58
4.58
mmol/l
0.00
60
640
38
383
0.99
0.00
2.0
2.1
—
—
—
0
0
50
496
1.02
0.00
4.5
3.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
199.63
—
0
7
0
5
0.00
-0.00
0.0
1.4
—
2301.40
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
65.33
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
1.19
—
0
7
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
12.56
—
0
5
0
7
0.00
-0.00
0.0
1.4
—
6.24
—
0
7
6
64
0.93
-0.00
1.7
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
1565.83
—
0
6

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: Z21_PROBL_RELATED_EDUCATION_LITER – Problems related to education and literacy

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).