No definition available.
Pervasive developmental disorders excl. Autism + Asperger
DOID EFO Endpoint Browser PheWeb
F5_PERVASIVE
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
461 |
4. Check minimum number of eventsNone |
461 |
5. Include endpointsNone |
461 |
6. Filter based on genotype QC (FinnGen only) |
461 |
Control definitions (FinnGen only)
- Control exclude
- F5_PSYCHDEV
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- F80-F89
- Name in latin
- Perturbationes formationales pervasivae (in pueritia)
Similar endpoints
↥List of similar endpoints to
Pervasive developmental disorders excl. Autism + Asperger
based on the number of shared cases.
Similar with more cases:
- Wide developmental disorders
- Wide developmental disorders, excluding more controls
- Disorders of psychological development
- Any mental disorder
- Psychiatric diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13185 | 3541 | 9638 |
| Only index persons | 10180 | 2894 | 7286 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.22 | 0.10 | 0.27 |
| Only index persons | 0.23 | 0.11 | 0.28 |
| Median age at first event (years) | |||
| Whole population | 8.61 | 10.02 | 8.07 |
| Only index persons | 10.22 | 11.89 | 9.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 461 | 186 | 275 |
| Unadjusted period prevalence (%) | 0.10 | 0.06 | 0.12 |
| Median age at first event (years) | 12.92 | 16.09 | 10.77 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 401
- Matched controls
- 3995
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F84.9
ICD-10 Finland
Pervasive developmental disorder, unspecified
+∞
323.0
279
*
F84.8
ICD-10 Finland
Other pervasive developmental disorders
+∞
164.0
146
*
F84.5
ICD-10 Finland
Asperger syndrome
833.8
127.8
119
*
F83
ICD-10 Finland
Mixed specific developmental disorders
+∞
88.8
82
*
N05AX08
ATC
risperidone; systemic
19.5
82.9
132
98
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
11.7
53.7
106
119
F84.0
ICD-10 Finland
Childhood autism
+∞
53.3
50
*
N05AX12
ATC
aripiprazole; systemic
12.1
48.0
92
96
F29
ICD-10 Finland
Unspecified nonorganic psychosis
11.5
44.9
88
95
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
9.2
44.5
100
139
N05AH04
ATC
quetiapine; oral
5.6
42.2
145
365
N05AH03
ATC
olanzapine; systemic
9.7
41.6
90
116
XA800
NOMESCO Finland
Neuropsychological investigation
11.6
40.7
79
83
N06BA04
ATC
methylphenidate; oral
8.9
38.5
87
120
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
11.6
37.9
73
75
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
9.3
37.8
83
109
F90.0
ICD-10 Finland
Disturbance of activity and attention
7.2
37.4
99
174
R62.0
ICD-10 Finland
Delayed milestone
15.6
33.7
56
41
IGV01
NOMESCO Finland
Psychiatric network contact
17.2
33.2
53
35
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.6
32.9
136
401
F80.2
ICD-10 Finland
Receptive language disorder
119.2
31.1
33
*
F82
ICD-10 Finland
Specific developmental disorder of motor function
73.7
30.4
34
5
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
7.4
30.2
76
122
F80.9
ICD-10 Finland
Developmental disorder of speech and language, unspecified
167.0
30.1
31
*
IEV99
NOMESCO Finland
Other psychiatric network intervention
21.7
29.4
43
22
N03AG01
ATC
valproic acid; systemic, rectal
7.8
29.4
71
107
F88
ICD-10 Finland
Other disorders of psychological development
312.5
29.1
29
*
IGY99
NOMESCO Finland
Other psychiatric treatment contact
8.5
29.1
66
90
N06AB03
ATC
fluoxetine; oral
6.1
28.5
84
167
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
10.1
27.5
56
63
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
5.3
26.3
88
202
IBZ06
NOMESCO Finland
Evaluation concerning developmental neuropsychiatry
23.8
26.1
37
17
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
11.4
25.8
49
48
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
16.9
25.1
40
26
IGP01
NOMESCO Finland
Psychiatric family contact
9.2
24.8
53
65
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
17.3
24.1
38
24
F80.1
ICD-10 Finland
Expressive language disorder
242.5
22.8
23
*
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
10.8
22.1
43
44
F20.9
ICD-10 Finland
Schizophrenia, unspecified
16.5
21.9
35
23
IAB03
NOMESCO Finland
Neuropsychiatric consultation
+∞
21.0
20
*
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
3.9
20.5
95
296
IEP99
NOMESCO Finland
Other psychiatric family intervention
14.8
19.9
33
24
F93.89
ICD-10 Finland
Other childhood emotional disorders
9.9
19.8
40
44
N06AB06
ATC
sertraline; oral
4.6
19.7
73
184
N06AB04
ATC
citalopram; systemic
4.4
19.6
76
200
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
6.1
19.6
55
101
N05BA06
ATC
lorazepam; systemic, sublingual
13.7
19.2
33
26
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
15.8
19.2
31
21
F99
ICD-10 Finland
Mental disorder, not otherwise specified
11.8
19.1
35
32
IFA99
NOMESCO Finland
Other psychiatric pharmacotherapy service
19.9
18.9
28
15
R5599
NOMESCO Finland
Other rehabilitation service
10.8
18.8
36
36
N05BA01
ATC
diazepam; systemic, rectal
4.6
18.6
68
169
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
38.5
17.8
22
6
N06AX16
ATC
venlafaxine; oral
4.2
17.7
73
203
F89
ICD-10 Finland
Unspecified disorder of psychological development
99.2
17.7
19
*
F80.8
ICD-10 Finland
Other developmental disorders of speech and language
99.2
17.7
19
*
N05AH02
ATC
clozapine; systemic
11.1
17.5
33
32
IGY02
NOMESCO Finland
Psychiatric monitoring contact
5.6
17.2
52
104
RS140
NOMESCO Finland
NA
26.9
17.1
23
9
N05AD01
ATC
haloperidol; systemic
15.9
16.9
27
18
P29
ICPC
Psychological sympt/compl other
4.3
16.9
67
180
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.3
16.7
94
335
RT420
NOMESCO Finland
NA
176.5
16.6
17
*
P85
ICPC
Mental retardation
21.1
16.6
24
12
N03AX09
ATC
lamotrigine; oral
5.5
16.6
50
100
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
6.8
16.4
42
68
R4120
NOMESCO Finland
Occupational therapy
5.6
16.4
49
97
Z50.5
ICD-10 Finland
Speech therapy
6.6
16.1
42
70
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.4
16.0
60
152
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
10.7
15.7
30
30
F92.8
ICD-10 Finland
Other mixed disorders of conduct and emotions
23.1
15.7
22
10
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
5.0
15.7
52
116
G40.9
ICD-10 Finland
Epilepsy, unspecified
7.3
15.3
37
55
F92.9
ICD-10 Finland
Mixed disorder of conduct and emotions, unspecified
14.9
14.7
24
17
F81.3
ICD-10 Finland
Mixed disorder of scholastic skills
+∞
14.7
14
*
Z03.2
ICD-10 Finland
Observation for suspected mental and behavioural disorders
7.6
14.6
34
48
N05BA04
ATC
oxazepam; oral
3.2
14.5
85
312
IEP03
NOMESCO Finland
Focused parental counselling
8.5
14.3
31
39
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
6.0
14.3
40
73
IBA04
NOMESCO Finland
Extensive initial psychiatric evaluation
5.7
14.2
41
78
F81.8
ICD-10 Finland
Other developmental disorders of scholastic skills
144.2
13.5
14
*
331
Kela drug reimbursment
Atomoxetine, dexamphetamine, guanfacine and lisdexamphetamine
12.0
13.5
24
21
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.3
13.3
51
132
Z01.1
ICD-10 Finland
Examination of ears and hearing
3.0
13.3
83
318
ICC01
NOMESCO Finland
Psychiatric treatment plan, transfer to psychiatric outpatient clinic
12.1
12.9
23
20
F84.2
ICD-10 Finland
Rett syndrome
+∞
12.5
12
*
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
5.9
12.5
35
64
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
3.4
12.5
65
218
F90.9
ICD-10 Finland
Hyperkinetic disorder, unspecified
11.0
12.4
23
22
N06AX12
ATC
bupropion; oral
4.0
12.3
50
137
R4130
NOMESCO Finland
Speech therapy
8.6
12.2
26
32
P99
ICPC
Psychological disorders other
6.1
12.2
33
58
RT150
NOMESCO Finland
NA
13.0
11.7
20
16
SPAT1389
SPAT
Visit based on need for special support
3.1
11.7
69
251
N05AE04
ATC
ziprasidone; systemic
31.0
11.7
15
5
F70.1
ICD-10 Finland
Mild mental retardation, Significant impairment of behaviour requiring attention or treatment
66.7
11.7
13
*
F60.9
ICD-10 Finland
Personality disorder, unspecified
11.6
11.6
21
19
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.8
11.6
50
144
IBA01
NOMESCO Finland
Diagnostic and symptom-mapping evaluation
5.0
11.5
37
80
113
Kela drug reimbursment
Anxiety disorders associated with mental retardation
+∞
11.5
11
*
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
4.4
11.5
42
104
RT160
NOMESCO Finland
NA
15.6
11.4
18
12
R1260
NOMESCO Finland
Evaluation of communicative skills
15.6
11.4
18
12
N05AN01
ATC
lithium; oral
9.3
11.4
23
26
RT490
NOMESCO Finland
NA
25.8
11.2
15
6
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
5.1
11.1
35
74
N03AF02
ATC
oxcarbazepine; oral
5.7
10.9
31
58
Z71.8
ICD-10 Finland
Other specified counselling
2.3
10.9
127
680
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
5.3
10.9
33
67
T36
ICD-10 Finland
Poisoning by systemic antibiotics
4.5
10.8
38
91
F79.1
ICD-10 Finland
Unspecified mental retardation, significant impairment of behaviour requiring attention or treatment
61.5
10.7
12
*
2998A
ICD-9 Finland
Psychoses with origin specific to childhood, Other specified early childhood psychoses[LAPSUUDEN LAAJA-ALAIN KEHITYSHÄIR,TÄYDEL OIREYHTYMÄ]
+∞
10.4
10
*
3159X
ICD-9 Finland
Specific delays in development, Unspecified delay in development
+∞
10.4
10
*
F84.4
ICD-10 Finland
Overactive disorder associated with mental retardation and stereotyped movements
+∞
10.4
10
*
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
9.1
10.4
21
24
N06AA04
ATC
clomipramine; systemic
19.3
10.3
15
8
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
7.2
10.2
24
35
F98.8
ICD-10 Finland
Other specified behavioural and emotional disorders with onset usually occurring in childhood and adolescence
8.8
10.2
21
25
R1210
NOMESCO Finland
Medical assessment of need and possibilities to rehabilitation
10.4
10.1
19
19
IBZ02
NOMESCO Finland
Somatic assessment of psychiatric patient
20.6
9.8
14
7
F79.9
ICD-10 Finland
Unspecified mental retardation, without mention of impairment of behaviour
20.6
9.8
14
7
IBB01
NOMESCO Finland
Psychiatric functioning capacity evaluation
20.6
9.8
14
7
P22
ICPC
Child behaviour symptom/complaint
4.1
9.6
37
97
3153A
ICD-9 Finland
Specific delays in development, Developmental speech or language disorder[KIELENKEHITYKSEN ERITYISVAIKEUS]
+∞
9.4
9
*
N03AX11
ATC
topiramate; oral
6.3
9.3
24
40
F42.2
ICD-10 Finland
Mixed obsessional thoughts and acts
9.8
9.3
18
19
F61.0
ICD-10 Finland
Mixed personality disorders
9.8
9.3
18
19
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
4.0
9.3
37
100
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.1
9.1
52
186
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
9.3
9.1
18
20
RS312
NOMESCO Finland
NA
37.5
9.0
11
*
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
4.7
9.0
30
68
N05BA09
ATC
clobazam; oral
7.7
9.0
20
27
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.1
9.0
50
174
F81.0
ICD-10 Finland
Specific reading disorder
24.6
8.9
12
5
Z63.5
ICD-10 Finland
Disruption of family by separation and divorce
12.9
8.9
15
12
N03AE01
ATC
clonazepam; systemic
5.8
8.9
24
43
N06AB10
ATC
escitalopram; oral
2.3
8.9
91
454
R1250
NOMESCO Finland
Evaluation of functional capability
11.0
8.8
16
15
F93.9
ICD-10 Finland
Childhood emotional disorder, unspecified
11.0
8.8
16
15
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
8.8
78
362
N06BA09
ATC
atomoxetine; oral
16.7
8.6
13
8
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
2.7
8.6
61
251
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.7
8.6
58
232
F91.3
ICD-10 Finland
Oppositional defiant disorder
28.1
8.5
11
*
F20.8
ICD-10 Finland
Other schizophrenia
28.1
8.5
11
*
RT190
NOMESCO Finland
NA
20.5
8.5
12
6
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
8.1
8.4
18
23
RL720
NOMESCO Finland
NA
+∞
8.3
8
*
F71.1
ICD-10 Finland
Moderate mental retardation, significant impairment of behaviour requiring attention or treatment
+∞
8.3
8
*
F40.1
ICD-10 Finland
Social phobias
4.2
8.3
31
79
IBA02
NOMESCO Finland
Evaluation of need for psychiatric rehabilitation
6.3
8.2
21
35
F21
ICD-10 Finland
Schizotypal disorder
14.8
8.2
13
9
IER04
NOMESCO Finland
Rehabilitative psychiatric group intervention, functional
7.8
8.2
18
24
F95.2
ICD-10 Finland
Combined vocal and multiple motor tic disorder [de la Tourette]
17.6
8.1
12
7
F81.9
ICD-10 Finland
Developmental disorder of scholastic skills, unspecified
34.0
8.1
10
*
N05AB03
ATC
perphenazine; systemic, rectal
6.8
8.0
19
29
Z31.5
ICD-10 Finland
Genetic counselling
3.3
7.9
39
126
RL140
NOMESCO Finland
NA
11.1
7.8
14
13
N05AA02
ATC
levomepromazine; systemic
5.5
7.8
22
42
F93.80
ICD-10 Finland
Generalized anxiety in the bardom age
45.7
7.7
9
*
N03AF01
ATC
carbamazepine; oral, rectal
6.9
7.7
18
27
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.5
7.6
34
102
RS110
NOMESCO Finland
NA
18.7
7.6
11
6
XA820
NOMESCO Finland
NA
12.1
7.6
13
11
183
Kela drug reimbursment
Lamotrigin and topiramate
6.7
7.5
18
28
IEY01
NOMESCO Finland
Psychoeducation, individual
7.9
7.4
16
21
R4170
NOMESCO Finland
Therapy forms involving educational rehabilitation
81.3
7.4
8
*
IFB01
NOMESCO Finland
Electroconvulsive Therapy (ECT)
13.7
7.4
12
9
R5140
NOMESCO Finland
Monitoring the use of the aid
4.4
7.3
25
59
F39
ICD-10 Finland
Unspecified mood [affective] disorder
5.3
7.3
21
41
3153X
ICD-9 Finland
Specific delays in development, Developmental speech or language disorder[PUHEEN KEHITYKSEN ERITYISVAIKEUS]
+∞
7.3
7
*
F84
ICD-10 Finland
Pervasive developmental disorders
+∞
7.3
7
*
2999A
ICD-9 Finland
Psychoses with origin specific to childhood, Unspecified[LAPSUUDEN LAAJA-AL.KEHITYSHÄIR,NUD,TÄYDEL OIREYHTYM]
+∞
7.3
7
*
F84.3
ICD-10 Finland
Other childhood disintegrative disorder
+∞
7.3
7
*
H52.1
ICD-10 Finland
Myopia
3.4
7.3
34
106
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
4.0
7.2
27
70
RT130
NOMESCO Finland
NA
30.5
7.2
9
*
F94.9
ICD-10 Finland
Childhood disorder of social functioning, unspecified
30.5
7.2
9
*
IER05
NOMESCO Finland
Rehabilitative psychiatric group intervention, social skills
20.4
7.2
10
5
F34.1
ICD-10 Finland
Dysthymia
4.5
7.1
24
56
Z72.8
ICD-10 Finland
Other problems related to lifestyle
10.3
7.1
13
13
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.3
7.0
34
109
N05AF03
ATC
chlorprothixene; systemic
6.5
7.0
17
27
F33.4
ICD-10 Finland
Recurrent depressive disorder, currently in remission
5.6
7.0
19
35
IEZ99
NOMESCO Finland
Other psychiatric rehabilitation intervention
14.0
6.9
11
8
Z61.8
ICD-10 Finland
Other negative life events in childhood
11.2
6.8
12
11
N06AX03
ATC
mianserin; oral
9.5
6.8
13
14
F92.0
ICD-10 Finland
Depressive conduct disorder
9.5
6.8
13
14
F94.0
ICD-10 Finland
Elective mutism
40.6
6.8
8
*
F90.1
ICD-10 Finland
Hyperkinetic conduct disorder
17.0
6.8
10
6
N06AX21
ATC
duloxetine; oral
3.3
6.7
32
102
U07
ICPC
Urine symptom/complaint other
4.7
6.7
21
46
IBB02
NOMESCO Finland
Psychiatric evaluation of working capacity and rehabilitation
10.2
6.6
12
12
RL130
NOMESCO Finland
NA
10.2
6.6
12
12
RS220
NOMESCO Finland
NA
5.5
6.5
18
34
F84.10
ICD-10 Finland
Autism in atypical age
70.7
6.4
7
*
Z29
ICPC
Social problem NOS
4.5
6.4
21
48
F42.9
ICD-10 Finland
Obsessive-compulsive disorder, unspecified
6.7
6.4
15
23
P27
ICPC
Fear of mental disorder
6.7
6.4
15
23
K03.66
ICD-10 Finland
Tooth plaque
2.3
6.4
60
285
P28
ICPC
Limited function/disability (P)
11.2
6.3
11
10
N06BA12
ATC
lisdexamfetamine; oral
9.4
6.3
12
13
N06AB05
ATC
paroxetine; oral
4.5
6.3
21
49
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
4.9
6.3
19
40
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.1
6.3
72
373
F41.8
ICD-10 Finland
Other specified anxiety disorders
4.2
6.3
22
54
N05AE05
ATC
lurasidone; oral
18.3
6.3
9
5
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
3.9
6.3
24
64
F84.11
ICD-10 Finland
Autism with atypical symptoms
+∞
6.3
6
*
2999B
ICD-9 Finland
Psychoses with origin specific to childhood, Unspecified[LAPSUUDEN LAAJA-ALAINEN KEHITYSHÄIRIÖ NUD,JÄLKITILA]
+∞
6.3
6
*
F94.8
ICD-10 Finland
Other childhood disorders of social functioning
+∞
6.3
6
*
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
7.2
6.3
14
20
T90
ICPC
Diabetes non-insulin dependent
3.5
6.2
27
80
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.8
6.2
37
138
H52.2
ICD-10 Finland
Astigmatism
4.4
6.2
21
50
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
7.8
6.2
13
17
RD210
NOMESCO Finland
NA
3.4
6.1
28
87
AA1AD
NOMESCO Finland
CT of head and brain
2.6
6.1
43
177
P72
ICPC
Schizophrenia
8.8
6.1
12
14
SPAT1229
SPAT
Assessment of need for aid
5.3
6.1
17
33
P23
ICPC
Adolescent behaviour sympt/compl
6.2
6.0
15
25
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
34
36
10.07
29.03
19.9
25.3
1355.7
1544.9
nmol/l
0.31
34
36
155
699
2.82
22.72
1.9
1.6
98.7
97.4
pmol/l
0.13
80
361
73
214
3.85
21.83
1.9
1.5
510.4
295.4
mu/l
2.61
67
197
70
209
3.75
20.33
1.6
1.6
895.9
1081.3
nmol/l
1.03
49
166
384
2814
3.17
19.85
5.8
3.9
1.9
1.9
mu/l
0.11
368
2640
243
1442
2.44
19.42
5.9
10.8
1.2
1.2
mmol/l
0.16
221
1314
233
1359
2.43
19.33
5.8
11.7
1.2
1.2
mmol/l
0.31
220
1286
346
2432
2.68
18.80
4.9
3.4
14.2
14.5
pmol/l
1.74
328
2224
156
766
2.55
18.74
2.7
2.9
2.4
2.4
mmol/l
0.43
142
690
406
3164
3.36
16.97
12.8
11.4
139.8
139.4
mmol/l
2.25
399
3070
406
3164
3.36
16.97
12.7
11.4
3.9
3.9
mmol/l
4.14
398
3051
209
1229
2.27
16.22
2.9
3.2
66.9
68.9
nmol/l
0.52
193
1159
114
514
2.61
16.05
2.2
1.8
1.6
1.4
%
2.63
106
470
116
563
2.41
13.75
3.8
2.4
260.4
500.0
u/l
0.86
109
551
91
398
2.59
13.45
1.7
1.3
17.9
19.4
nmol/l
0.56
85
350
283
1998
2.07
12.54
6.0
6.0
103.1
101.8
u/l
0.09
264
1873
171
1008
2.10
12.42
4.3
4.1
29.6
34.9
u/l
2.26
164
955
312
2301
2.09
12.04
4.7
2.5
5.7
5.5
mmol/l
1.30
292
2116
13
13
10.21
11.32
2.3
2.2
20.8
14.5
umol/l
0.82
13
13
163
999
1.97
10.25
4.0
8.1
38.4
38.0
g/l
0.34
148
956
406
3415
2.56
10.03
9.7
8.2
30.5
28.4
u/l
0.79
396
3311
243
1743
1.82
9.04
5.4
7.0
6.1
6.2
mmol/l
0.60
226
1610
109
620
1.98
8.26
1.6
1.8
1.4
1.4
mmol/l
0.02
103
558
60
281
2.29
7.48
1.7
1.5
425.9
26070487.1
pmol/l
0.50
48
257
311
2489
1.75
7.18
4.1
2.9
2.8
2.8
mmol/l
0.55
290
2341
310
2498
1.72
6.78
4.1
2.9
4.5
4.5
mmol/l
0.40
295
2374
24
75
3.31
6.46
2.0
1.6
—
—
—
0
0
61
306
2.13
6.43
2.4
2.3
8.5
13.2
nmol/l
3.16
49
257
305
2471
1.68
6.29
4.0
2.8
1.3
1.4
mmol/l
5.72
288
2339
291
2342
1.64
6.04
3.6
2.7
1.3
1.2
mmol/l
1.47
273
2228
34
136
2.61
5.95
1.7
1.5
—
—
—
0
0
287
2318
1.62
5.73
10.9
7.2
108.6
105.2
ml/min/173m2
1.60
205
1678
34
139
2.55
5.71
1.8
1.7
—
—
—
0
0
70
391
1.92
5.48
2.7
2.7
339.8
348.8
nmol/l
0.16
70
367
382
3340
1.82
5.47
18.6
13.8
13.1
13.2
%
0.46
376
3293
54
276
2.07
5.42
2.2
2.2
2.4
2.4
mmol/l
0.76
43
233
50
249
2.12
5.37
2.0
1.9
14.1
11.5
iu/l
0.27
35
171
92
569
1.76
5.20
3.2
3.6
1.7
1.6
e6/l
0.06
40
322
135
929
1.63
5.12
3.8
3.8
0.4
0.3
e6/l
0.40
96
702
171
1246
1.58
5.12
4.9
7.1
19.5
19.2
umol/l
0.02
161
1160
54
283
2.02
5.07
2.1
2.5
24.5
33.7
u/l
2.08
46
234
70
405
1.85
4.92
1.9
1.8
—
—
—
0
0
261
2110
1.53
4.80
4.8
3.6
32.2
31.5
u/l
0.10
252
2032
109
721
1.66
4.80
2.8
2.8
53.2
57.5
u/l
0.63
99
679
49
255
2.02
4.69
2.2
2.0
7.0
6.0
u/l
0.31
34
176
267
2182
1.52
4.58
14.6
10.4
3.7
3.7
e9/l
0.00
220
1837
55
305
1.90
4.40
1.7
1.8
—
—
—
0
0
147
1070
1.54
4.28
3.8
4.0
—
—
—
0
0
114
787
1.59
4.18
2.1
3.2
2.4
2.7
mg/l
1.39
97
702
54
306
1.86
4.05
1.7
1.8
—
—
—
0
0
87
566
1.65
4.05
3.3
3.3
0.3
0.7
e6/l
1.52
36
316
254
2090
1.47
3.97
5.5
3.5
36.8
36.9
mmol/mol
0.06
234
1994
50
291
1.80
3.46
1.3
1.3
153.7
126.0
iu/ml
0.13
13
106
89
610
1.56
3.32
4.0
9.7
1.1
1.1
mmol/l
0.02
73
463
14
344
0.39
3.27
1.5
1.5
—
—
—
0
0
15
348
0.41
3.07
1.7
1.4
—
—
—
0
0
5
5
10.04
2.97
1.4
2.2
—
—
—
0
0
62
402
1.62
2.92
2.1
2.9
2.6
2.5
g/l
0.17
53
379
343
3702
0.69
2.81
3.5
3.8
—
—
—
0
0
35
195
1.85
2.81
3.4
2.5
29.5
30.5
%
0.21
26
141
65
437
1.56
2.64
2.3
2.9
14.8
14.1
umol/l
0.26
58
419
60
396
1.58
2.64
2.2
5.6
6.2
7.8
umol/l
0.32
49
325
9
25
3.63
2.57
1.1
1.2
—
—
—
0
0
10
33
3.06
2.52
1.1
1.1
—
—
—
0
0
25
130
1.97
2.47
3.4
12.6
1.1
1.1
inr
—
7
30
6
174
0.33
2.46
1.3
1.6
—
—
—
0
0
6
165
0.35
2.19
1.3
1.9
—
—
—
0
0
11
42
2.65
2.18
6.2
3.2
1.7
1.8
mmol/l
0.07
11
42
84
620
1.43
2.18
5.0
10.0
1.2
1.3
mmol/l
1.72
78
591
37
231
1.65
2.06
2.1
2.7
0.8
1.3
ug/l
1.46
29
211
12
51
2.38
1.94
5.8
4.0
18.2
18.4
%
—
5
34
6
156
0.37
1.93
1.8
1.7
—
—
—
0
0
54
375
1.49
1.92
2.3
3.0
24.3
22.6
%
0.29
48
351
384
3587
1.40
1.92
11.6
10.1
21.2
22.7
mg/l
0.33
267
2471
45
645
0.66
1.89
2.9
2.0
—
—
—
0
0
22
121
1.85
1.89
1.1
1.3
—
—
—
0
0
22
121
1.85
1.89
1.1
1.3
—
—
—
0
0
12
243
0.48
1.79
2.7
1.8
—
—
—
0
0
26
414
0.60
1.75
1.3
1.4
—
—
—
0
0
250
2224
1.26
1.68
3.9
3.9
6.8
7.4
mm/h
0.61
235
2081
37
537
0.66
1.66
2.7
1.9
—
—
—
0
0
18
101
1.81
1.49
6.2
8.4
25.6
24.5
mmol/l
1.08
18
96
60
448
1.38
1.48
2.6
3.4
70.9
1456.1
ng/l
3.47
28
243
19
109
1.77
1.47
1.3
1.1
—
—
—
0
0
105
1261
0.78
1.46
3.1
4.1
—
—
—
0
0
184
1601
1.24
1.45
2.9
3.1
55.3
66.7
ug/l
1.32
164
1512
19
110
1.75
1.43
1.3
1.1
—
—
—
0
0
14
248
0.55
1.42
1.3
1.2
—
—
—
0
0
56
726
0.74
1.35
2.4
2.8
—
—
—
0
0
0
38
0.00
1.35
0.0
2.4
—
—
—
0
0
158
1366
1.23
1.30
1.7
1.7
1.0
3.1
u/ml
2.08
26
267
6
24
2.51
1.30
1.7
1.5
—
—
—
0
0
11
55
2.02
1.27
1.5
1.5
4.1
11.9
u/l
2.50
11
49
13
226
0.56
1.25
2.1
1.8
—
—
—
0
0
94
1124
0.79
1.25
3.0
2.5
—
—
—
0
0
27
179
1.53
1.24
5.0
2.3
—
—
—
0
0
6
25
2.41
1.24
1.8
1.8
8.8
10.0
umol/l
—
6
25
13
70
1.87
1.23
1.2
1.2
—
16.0
—
0
6
12
212
0.55
1.23
1.6
8.4
3.5
2.9
g/l
0.76
12
207
11
56
1.98
1.21
1.0
1.2
—
—
—
0
0
86
1031
0.79
1.16
3.2
3.1
—
—
—
0
0
11
57
1.94
1.16
4.7
5.9
2.2
2.1
ug/l
0.02
11
57
9
161
0.55
1.10
1.0
1.5
—
—
—
0
0
9
161
0.55
1.10
1.0
1.5
—
—
—
0
0
9
161
0.55
1.10
1.0
1.5
—
—
—
0
0
9
162
0.54
1.10
1.0
1.5
—
—
—
0
0
142
1604
0.83
1.08
2.0
1.9
—
—
—
0
0
22
315
0.68
0.98
1.0
1.3
2.5
2.4
u/ml
0.02
16
212
30
216
1.41
0.96
2.3
1.7
—
—
—
0
0
13
78
1.68
0.91
1.5
1.4
—
—
—
0
0
15
228
0.64
0.90
1.5
1.3
—
—
—
0
0
6
115
0.51
0.83
1.0
1.1
—
—
—
0
0
91
1047
0.83
0.83
2.8
2.3
—
—
—
0
0
12
187
0.63
0.81
1.3
1.5
—
—
—
0
0
0
24
0.00
0.79
0.0
1.1
—
—
—
0
0
6
33
1.82
0.79
1.0
1.2
—
—
—
0
0
10
59
1.70
0.75
1.1
1.2
—
—
—
0
0
10
156
0.63
0.69
1.2
1.1
—
—
—
0
0
24
178
1.36
0.68
2.9
4.2
—
—
—
0
0
7
119
0.58
0.68
1.1
1.3
—
—
—
0
0
62
725
0.83
0.68
3.1
3.5
0.0
0.0
estimate
0.50
25
277
11
166
0.65
0.67
1.0
1.1
0.0
0.4
u/ml
—
6
81
51
422
1.23
0.66
1.1
1.1
—
—
—
0
0
69
589
1.20
0.66
7.3
8.2
0.8
0.8
mmol/l
0.01
46
410
23
173
1.34
0.61
1.3
1.4
—
—
—
0
0
5
30
1.67
0.61
4.4
2.5
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
22
0.00
0.59
0.0
1.8
—
—
—
0
0
0
23
0.00
0.58
0.0
1.2
—
—
—
0
0
13
89
1.47
0.57
2.8
1.8
—
—
—
0
0
17
123
1.39
0.57
1.8
1.9
0.4
0.6
ug/l
—
9
51
12
81
1.49
0.56
2.8
1.8
—
—
—
0
0
69
599
1.17
0.56
1.6
3.8
0.7
1.7
mg/l
1.75
47
412
6
37
1.62
0.55
1.5
1.1
—
—
—
0
0
8
121
0.65
0.55
1.5
1.9
—
—
—
0
0
30
241
1.26
0.52
1.4
1.4
—
—
—
0
0
7
45
1.56
0.49
1.1
1.1
—
—
—
0
0
10
142
0.69
0.48
2.5
1.6
1.1
1.2
g/l
—
10
136
27
218
1.25
0.46
2.0
1.7
—
—
—
0
0
5
83
0.60
0.46
1.2
1.7
—
—
—
0
0
6
91
0.65
0.42
1.5
1.8
39.3
38.0
u/l
—
6
85
5
32
1.56
0.42
1.2
1.1
—
—
—
0
0
5
32
1.56
0.42
1.0
1.3
—
—
—
0
0
5
32
1.56
0.42
1.2
1.1
—
—
—
0
0
5
32
1.56
0.42
1.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
5
33
1.51
0.41
1.2
1.2
—
—
—
0
0
5
33
1.51
0.41
1.2
1.2
—
—
—
0
0
5
33
1.51
0.41
1.0
1.2
—
—
—
0
0
5
33
1.51
0.41
1.2
1.2
—
—
—
0
0
5
33
1.51
0.41
1.0
1.2
—
—
—
0
0
5
33
1.51
0.41
1.0
1.2
—
—
—
0
0
5
34
1.47
0.40
1.2
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
24
199
1.21
0.34
5.0
16.1
11.8
15.4
kpa
3.53
24
187
24
199
1.21
0.34
5.0
16.1
5.2
5.2
kpa
0.02
24
187
24
199
1.21
0.34
5.0
16.1
-0.0
0.6
mmol/l
0.33
19
160
382
3737
1.10
0.31
17.6
12.7
40.5
40.3
%
0.23
315
3336
8
63
1.27
0.28
1.1
1.2
123.8
110.2
%
—
8
58
9
118
0.75
0.27
1.6
1.8
—
—
—
0
0
6
82
0.72
0.24
1.0
1.2
—
—
—
0
0
5
38
1.31
0.23
1.0
1.1
—
—
—
0
0
5
39
1.28
0.23
1.4
1.3
310.8
41.7
pmol/l
—
5
39
5
40
1.25
0.22
1.2
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
25.1
—
0
10
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
10
123
0.81
0.21
1.9
3.7
0.1
0.1
e6/l
—
10
117
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
0
13
0.00
0.21
0.0
2.0
—
—
—
0
0
0
13
0.00
0.21
0.0
2.2
—
—
—
0
0
0
13
0.00
0.21
0.0
2.8
—
—
—
0
0
44
402
1.10
0.20
1.3
1.2
13.4
21.1
iu/ml
—
8
103
6
50
1.20
0.19
1.0
1.0
176.8
164.0
g/l
—
6
50
6
52
1.15
0.19
1.0
1.4
—
264.3
—
0
14
31
281
1.11
0.17
3.9
2.6
3520.9
3983.7
u/l
—
9
114
8
71
1.12
0.16
1.1
1.1
—
—
—
0
0
6
75
0.79
0.15
1.0
3.2
11.2
9.5
%
—
6
69
6
75
0.79
0.15
1.0
3.2
—
—
—
0
0
15
130
1.15
0.15
6.3
19.3
95.5
95.6
%
0.03
15
130
37
388
0.94
0.09
7.4
12.7
5.5
5.6
mmol/l
0.07
37
378
6
58
1.03
0.08
1.0
4.7
27.5
24.9
umol/l
—
6
58
5
61
0.81
0.08
1.2
1.6
—
—
—
0
0
5
62
0.80
0.08
1.2
1.2
6.9
7.3
u/ml
—
5
56
12
107
1.12
0.08
2.7
2.7
61.3
23.2
mu/l
0.45
12
101
8
73
1.09
0.07
1.8
1.6
—
—
—
0
0
42
436
0.95
0.07
2.7
4.0
317.7
2008.9
umol/l
0.80
35
404
37
352
1.05
0.07
3.3
5.4
228.9
705.6
ng/l
2.87
30
265
9
87
1.03
0.07
1.4
1.8
—
—
—
0
0
32
304
1.05
0.06
1.7
1.3
—
—
—
0
0
142
1432
0.98
0.05
3.4
3.2
0.0
0.0
estimate
0.00
25
271
59
602
0.97
0.04
4.6
2.3
14.3
55.4
ng/l
0.65
31
245
54
526
1.02
0.03
8.4
8.1
9.6
9.7
kpa
0.18
54
510
39
380
1.02
0.02
1.3
1.2
30.3
5.7
u/ml
—
8
147
144
1442
0.99
0.01
3.3
3.3
0.0
0.0
estimate
0.00
26
278
14
138
1.01
0.00
1.1
1.1
—
8.3
—
0
21
18
177
1.01
0.00
1.4
1.8
—
—
—
0
0
144
1433
1.00
0.00
5.2
4.6
0.0
0.0
estimate
0.00
26
290
0
8
0.00
0.00
0.0
1.9
—
208.6
—
0
8
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
3.3
—
26.1
—
0
8
0
8
0.00
0.00
0.0
5.1
—
3.8
—
0
8
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
5
52
0.96
0.00
1.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
0.00
0.0
3.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
4.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
8
79
1.01
0.00
3.0
12.5
23.7
24.2
mmol/l
—
8
70
0
9
0.00
0.00
0.0
2.9
—
49.0
—
0
9
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
8
83
0.96
0.00
2.1
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
6
69
0.86
0.00
1.0
3.1
28.7
26.4
%
—
6
69
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
2.5
—
3.5
—
0
6
5
50
1.00
0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
739.0
—
0
5
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint F5_PERVASIVE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_PERVASIVE | 4.437 [2.83, 6.96] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.09 |
During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 2735 females with F5_PERVASIVE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_PERVASIVE | 2.447 [1.92, 3.12] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 94 out of 7819 males with F5_PERVASIVE died.
Mortality risk
Mortality risk for people of age
years, who have F5_PERVASIVE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.416% | 0.596% |
| 5 | 2.348% | 2.963% |
| 10 | 6.356% | 6.658% |
| 15 | 12.009% | 12.015% |
| 20 | 20.443% | 20.517% |
Relationships between endpoints
↥Index endpoint: F5_PERVASIVE – Pervasive developmental disorders excl. Autism + Asperger
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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