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Pervasive developmental disorders excl. Autism + Asperger

DOID EFO Endpoint Browser PheWeb

F5_PERVASIVE

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F84
  • Hospital discharge: ICD-9 — 2998|2999B
  • Hospital discharge: excluded ICD-10 — F84.0, F84.1, F84.5
  • Cause of death: ICD-10 — F84
  • Cause of death: ICD-9 — 2998|2999B
  • Cause of death: excluded ICD-10 — F84.0, F84.1, F84.5

2 out of 7 registries used, show all original rules.

507

4. Check minimum number of events

None

507

5. Include endpoints

None

507

6. Filter based on genotype QC (FinnGen only)

451

Control definitions (FinnGen only)

Control exclude
F5_PSYCHDEV

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F80-F89
Name in latin
Perturbationes formationales pervasivae (in pueritia)

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 13185 3541 9638
Only index persons 10180 2894 7286
Unadjusted period prevalence (%)
Whole population 0.22 0.10 0.27
Only index persons 0.23 0.11 0.28
Median age at first event (years)
Whole population 8.61 10.02 8.07
Only index persons 10.22 11.89 9.55

-FinnGen-

Key figures

All Female Male
Number of individuals 451 195 256
Unadjusted period prevalence (%) 0.10 0.07 0.12
Median age at first event (years) 13.68 16.45 11.57

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
506
Matched controls
5004
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F84.9
ICD-10 Finland
Pervasive developmental disorder, unspecified
3062.2
307.7
330
*
F84.8
ICD-10 Finland
Other pervasive developmental disorders
+∞
250.8
220
*
N05AX08
ATC
risperidone; systemic
16.2
167.2
166
146
F84.5
ICD-10 Finland
Asperger syndrome
233.3
151.5
150
9
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
15.6
138.0
135
114
IBZ06
NOMESCO Finland
Evaluation concerning developmental neuropsychiatry
33.8
115.2
76
26
F83
ICD-10 Finland
Mixed specific developmental disorders
633.3
107.6
103
*
N05AX12
ATC
aripiprazole; systemic
11.3
105.8
127
144
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
9.7
104.4
145
199
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
11.5
104.2
123
136
Z2445
NOMESCO Finland
Psychologist
9.1
103.2
153
227
ZY010
NOMESCO Finland
Hospital outpatient
8.5
98.7
157
252
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
9.4
94.1
131
179
IGV01
NOMESCO Finland
Psychiatric network contact
15.5
93.3
87
66
F90.0
ICD-10 Finland
Disturbance of activity and attention
7.3
91.5
171
325
F29
ICD-10 Finland
Unspecified nonorganic psychosis
11.0
91.0
109
122
XA800
NOMESCO Finland
Neuropsychological investigation
11.9
87.8
98
99
N06BA04
ATC
methylphenidate; oral
7.4
86.7
158
291
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
8.1
81.7
130
206
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
10.0
80.2
102
123
Z2446
NOMESCO Finland
Social worker
6.4
79.0
171
371
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
7.6
75.1
125
207
IGY99
NOMESCO Finland
Other psychiatric treatment contact
8.4
72.7
107
154
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
5.5
72.3
196
517
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
6.1
72.2
159
348
IEV99
NOMESCO Finland
Other psychiatric network intervention
16.0
71.1
64
45
N05AH03
ATC
olanzapine; systemic
7.7
70.1
113
180
R62.0
ICD-10 Finland
Delayed milestone
13.7
69.9
69
57
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
10.1
67.5
83
95
N05AH04
ATC
quetiapine; oral
5.1
67.4
200
565
IGP01
NOMESCO Finland
Psychiatric family contact
9.6
67.1
86
104
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
13.0
63.1
64
55
F84.0
ICD-10 Finland
Childhood autism
+∞
61.5
58
*
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
10.8
60.7
70
73
N06AB03
ATC
fluoxetine; oral
6.1
57.3
118
239
IFA99
NOMESCO Finland
Other psychiatric pharmacotherapy service
17.2
57.2
49
31
ZYC01
NOMESCO Finland
Remote contact by phone
7.1
56.6
96
160
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
9.3
56.3
73
89
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
6.9
56.2
98
168
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
13.4
55.8
55
45
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
5.9
54.4
116
242
IBA01
NOMESCO Finland
Diagnostic and symptom-mapping evaluation
7.5
53.3
84
129
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
6.8
53.2
94
163
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
5.7
51.8
113
240
N03AG01
ATC
valproic acid; systemic, rectal
7.1
51.8
87
143
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
12.1
50.3
53
48
IBA04
NOMESCO Finland
Extensive initial psychiatric evaluation
7.4
50.2
80
124
ZXY82
NOMESCO Finland
Nurse in multidisciplinary team
20.8
50.1
39
20
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
6.0
48.6
97
189
IGY02
NOMESCO Finland
Psychiatric monitoring contact
5.6
47.2
103
218
R5599
NOMESCO Finland
Other rehabilitation service
11.1
45.9
51
50
ZXY80
NOMESCO Finland
Doctor in multidisciplinary team
20.1
45.6
36
19
ZXE17
NOMESCO Finland
Procedure duration 150 to 179 minutes
10.2
44.7
53
57
F32.9
ICD-10 Finland
Depressive episode, unspecified
4.2
43.0
148
451
Z3226
NOMESCO Finland
Physiotherapist
3.9
42.7
170
574
F93.89
ICD-10 Finland
Other childhood emotional disorders
8.9
42.5
56
69
F80.9
ICD-10 Finland
Developmental disorder of speech and language, unspecified
437.2
41.6
41
*
F88
ICD-10 Finland
Other disorders of psychological development
154.5
41.2
43
*
IEP99
NOMESCO Finland
Other psychiatric family intervention
9.6
41.2
51
58
F82
ICD-10 Finland
Specific developmental disorder of motor function
150.6
40.2
42
*
N06AB06
ATC
sertraline; oral
4.4
39.9
122
339
F80.2
ICD-10 Finland
Receptive language disorder
208.5
38.2
39
*
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
14.1
38.1
36
27
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
6.8
37.3
63
103
F20.9
ICD-10 Finland
Schizophrenia, unspecified
12.2
36.9
38
33
F99
ICD-10 Finland
Mental disorder, not otherwise specified
9.0
36.6
47
56
N03AX09
ATC
lamotrigine; oral
6.0
36.0
69
128
N05BA01
ATC
diazepam; systemic, rectal
5.2
35.4
82
181
IEP03
NOMESCO Finland
Focused parental counselling
7.9
35.3
51
70
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
5.7
35.2
72
142
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
5.6
35.2
73
146
Z2221
NOMESCO Finland
Medical doctor
3.3
34.9
188
757
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
10.6
34.4
39
39
Z3231
NOMESCO Finland
Registered nurse
3.1
34.2
228
1038
Z50.5
ICD-10 Finland
Speech therapy
7.0
33.4
54
84
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
5.8
32.9
65
124
IER01
NOMESCO Finland
Psychoeducation, group
12.9
32.3
32
26
N06AB04
ATC
citalopram; systemic
4.4
32.2
93
245
R4120
NOMESCO Finland
Occupational therapy
5.6
32.0
66
131
331
Kela drug reimbursment
Atomoxetine, dexamphetamine, guanfacine and lisdexamphetamine
7.0
31.7
51
79
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
5.4
31.4
67
137
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
3.4
30.9
144
526
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
4.8
30.7
77
181
P99
ICPC
Psychological disorders other
7.2
30.7
48
72
Z03.2
ICD-10 Finland
Observation for suspected mental and behavioural disorders
7.3
30.6
47
69
N05BA06
ATC
lorazepam; systemic, sublingual
9.5
30.3
37
41
IER02
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, group
9.8
30.0
36
39
F89
ICD-10 Finland
Unspecified disorder of psychological development
87.2
30.0
33
*
N06AX16
ATC
venlafaxine; oral
3.8
28.6
102
312
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.5
28.4
76
188
P29
ICPC
Psychological sympt/compl other
3.6
27.4
110
363
ZXE01
NOMESCO Finland
Procedure duration 0 to 9 minutes
8.6
27.3
36
44
ICC01
NOMESCO Finland
Psychiatric treatment plan, transfer to psychiatric outpatient clinic
10.5
27.3
31
31
N05AH02
ATC
clozapine; systemic
8.3
27.2
37
47
ZY000
NOMESCO Finland
Hospital inpatient
8.3
27.2
37
47
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
5.7
27.0
53
100
SPAT1389
SPAT
Visit based on need for special support
3.7
27.0
101
318
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
5.7
26.7
53
101
G40.9
ICD-10 Finland
Epilepsy, unspecified
6.6
26.7
45
73
N06AX12
ATC
bupropion; oral
4.0
26.6
85
240
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.7
26.5
67
158
F80.1
ICD-10 Finland
Expressive language disorder
140.7
25.7
27
*
R4130
NOMESCO Finland
Speech therapy
7.4
25.4
38
54
F80.8
ICD-10 Finland
Other developmental disorders of speech and language
135.2
24.7
26
*
P85
ICPC
Mental retardation
21.8
24.1
35
17
N06BA12
ATC
lisdexamfetamine; oral
6.6
24.0
40
64
IAB03
NOMESCO Finland
Neuropsychiatric consultation
90.2
23.8
26
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
4.4
23.2
64
161
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
3.5
22.4
86
274
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
4.0
22.2
68
185
IER04
NOMESCO Finland
Rehabilitative psychiatric group intervention, functional
9.3
22.0
27
30
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
45.0
21.5
26
6
IBA02
NOMESCO Finland
Evaluation of need for psychiatric rehabilitation
6.5
21.4
36
58
T36
ICD-10 Finland
Poisoning by systemic antibiotics
4.7
20.7
50
113
IBB01
NOMESCO Finland
Psychiatric functioning capacity evaluation
26.5
20.5
28
11
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
5.6
20.4
40
75
N05AB03
ATC
perphenazine; systemic, rectal
7.4
20.3
30
42
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
5.0
19.7
44
93
N05BA04
ATC
oxazepam; oral
2.8
19.5
119
495
F92.9
ICD-10 Finland
Mixed disorder of conduct and emotions, unspecified
16.2
19.4
31
20
F90.9
ICD-10 Finland
Hyperkinetic disorder, unspecified
6.1
19.1
34
58
N05AD01
ATC
haloperidol; systemic
15.5
19.0
31
21
N03AF02
ATC
oxcarbazepine; oral
5.2
18.8
40
81
IAZ98
NOMESCO Finland
Other internal psychiatric consultation
15.7
18.5
30
20
RS140, ,
NOMESCO Finland
31.0
18.4
24
8
N05AA02
ATC
levomepromazine; systemic
6.6
18.3
30
47
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
6.6
18.3
30
47
F92.8
ICD-10 Finland
Other mixed disorders of conduct and emotions
23.6
17.8
25
11
F42.2
ICD-10 Finland
Mixed obsessional thoughts and acts
6.8
17.4
28
43
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.7
17.1
106
442
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.2
17.1
73
247
ZYB04
NOMESCO Finland
Outreach service in patient’s home or everyday environment
14.6
16.9
28
20
N05BA09
ATC
clobazam; oral
7.7
16.9
24
32
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
7.7
16.9
24
32
N03AX11
ATC
topiramate; oral
6.0
16.1
29
50
F93.9
ICD-10 Finland
Childhood emotional disorder, unspecified
14.0
16.1
27
20
Z01.8
ICD-10 Finland
Other specified special examinations
2.6
16.0
116
521
N06AX26
ATC
vortioxetine; oral
3.2
15.7
66
221
RT150, ,
NOMESCO Finland
17.7
15.7
24
14
ZXY83
NOMESCO Finland
Social worker in multidisciplinary team
19.8
15.6
23
12
F81.8
ICD-10 Finland
Other developmental disorders of scholastic skills
86.9
15.6
17
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
6.4
15.4
26
42
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.2
15.3
68
235
P22
ICPC
Child behaviour symptom/complaint
3.7
15.3
51
147
F79.1
ICD-10 Finland
Unspecified mental retardation, significant impairment of behaviour requiring attention or treatment
57.8
14.8
17
*
N06AX22
ATC
agomelatine; oral
6.1
14.7
26
44
Z3229
NOMESCO Finland
Other healthcare associate professional
3.1
14.7
66
230
ZXY01
NOMESCO Finland
Chief Physician, Head of Department or Deputy Chief Physician
12.3
14.6
26
22
F84.4
ICD-10 Finland
Overactive disorder associated with mental retardation and stereotyped movements
+∞
14.6
14
*
N05AF03
ATC
chlorprothixene; systemic
6.8
14.4
23
35
F98.8
ICD-10 Finland
Other specified behavioural and emotional disorders with onset usually occurring in childhood and adolescence
11.7
14.3
26
23
F34.1
ICD-10 Finland
Dysthymia
4.5
14.3
36
84
RT420, ,
NOMESCO Finland
27.8
14.3
19
7
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
4.7
14.2
34
76
F60.9
ICD-10 Finland
Personality disorder, unspecified
12.3
14.1
25
21
F81.3
ICD-10 Finland
Mixed disorder of scholastic skills
43.3
14.1
17
*
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
13.1
13.9
24
19
ZXY81
NOMESCO Finland
Psychologist in multidisciplinary team
13.1
13.9
24
19
Z71.8
ICD-10 Finland
Other specified counselling
2.1
13.9
200
1190
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.7
13.7
81
328
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.7
13.6
45
129
F84.2
ICD-10 Finland
Rett syndrome
+∞
13.5
13
*
SPAT1234
SPAT
Support of social functional capacity
5.6
13.5
26
48
ZXY60
NOMESCO Finland
2-person team, nurses
13.2
13.4
23
18
IER05
NOMESCO Finland
Rehabilitative psychiatric group intervention, social skills
26.3
13.4
18
7
OAB43, ,
SPAT
0.3
13.1
51
1251
F41.8
ICD-10 Finland
Other specified anxiety disorders
3.9
13.0
39
104
N06AB10
ATC
escitalopram; oral
2.3
12.9
127
648
IEZ99
NOMESCO Finland
Other psychiatric rehabilitation intervention
19.5
12.9
19
10
RT490, ,
NOMESCO Finland
23.0
12.9
18
8
F70.1
ICD-10 Finland
Mild mental retardation, Significant impairment of behaviour requiring attention or treatment
50.8
12.8
15
*
F33.4
ICD-10 Finland
Recurrent depressive disorder, currently in remission
4.7
12.8
30
66
ZXE21
NOMESCO Finland
Procedure duration at least 3 but less than 4 hours
10.8
12.8
24
23
ZXY03
NOMESCO Finland
Occupational therapist
14.4
12.8
21
15
N03AX14
ATC
levetiracetam; systemic
5.0
12.3
27
56
N05AN01
ATC
lithium; oral
5.0
12.3
27
56
ICB06, ,
NOMESCO Finland
9.2
12.3
25
28
R1210
NOMESCO Finland
Medical assessment of need and possibilities to rehabilitation
9.9
12.3
24
25
N03AE01
ATC
clonazepam; systemic
4.7
12.1
28
61
IEY01
NOMESCO Finland
Psychoeducation, individual
8.9
12.0
25
29
SPAT1307
SPAT
Psychosocial counselling and guidance
2.5
12.0
86
382
ZXY56
NOMESCO Finland
2-person team, nurse-psychologist
15.0
11.8
19
13
F40.1
ICD-10 Finland
Social phobias
3.4
11.7
44
137
IFB01
NOMESCO Finland
Electroconvulsive Therapy (ECT)
19.3
11.6
17
9
F42.9
ICD-10 Finland
Obsessive-compulsive disorder, unspecified
8.8
11.5
24
28
Z31.5
ICD-10 Finland
Genetic counselling
3.1
11.5
52
181
N05AE04
ATC
ziprasidone; systemic
15.3
11.3
18
12
ZXY57
NOMESCO Finland
2-person team, nurse-social worker
17.3
11.2
17
10
N05BE01
ATC
buspirone; oral
5.2
11.2
23
45
F81.0
ICD-10 Finland
Specific reading disorder
20.4
11.1
16
8
F95.2
ICD-10 Finland
Combined vocal and multiple motor tic disorder [de la Tourette]
20.4
11.1
16
8
F79.9
ICD-10 Finland
Unspecified mental retardation, without mention of impairment of behaviour
20.4
11.1
16
8
F39
ICD-10 Finland
Unspecified mood [affective] disorder
4.7
11.1
26
57
F32.8
ICD-10 Finland
Other depressive episodes
5.7
11.1
21
38
R5140
NOMESCO Finland
Monitoring the use of the aid
4.1
11.0
31
79
RS220, ,
NOMESCO Finland
5.4
11.0
22
42
RL140, ,
NOMESCO Finland
15.8
10.8
17
11
RL130, ,
NOMESCO Finland
18.1
10.7
16
9
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
18.1
10.7
16
9
RS312, ,
NOMESCO Finland
60.6
10.6
12
*
IBB02
NOMESCO Finland
Psychiatric evaluation of working capacity and rehabilitation
8.7
10.6
22
26
183
Kela drug reimbursment
Lamotrigin and topiramate
8.7
10.6
22
26
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
4.4
10.5
27
64
113
Kela drug reimbursment
Anxiety disorders associated with mental retardation
111.0
10.4
11
*
3159X
ICD-9 Finland
Specific delays in development, Unspecified delay in development
+∞
10.4
10
*
2998A
ICD-9 Finland
Psychoses with origin specific to childhood, Other specified early childhood psychoses[LAPSUUDEN LAAJA-ALAIN KEHITYSHÄIR,TÄYDEL OIREYHTYMÄ]
+∞
10.4
10
*
F61.0
ICD-10 Finland
Mixed personality disorders
7.9
10.4
23
30
ZYY79
NOMESCO Finland
Other indirect service without contact with patient
16.3
10.3
16
10
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
2.2
10.2
95
470
N05CD08
ATC
midazolam; nasal, systemic
4.1
10.2
28
70
N06AB05
ATC
paroxetine; oral
4.1
10.2
28
70
N06AA04
ATC
clomipramine; systemic
11.5
10.1
18
16
SPAT1240
SPAT
Therapeutic discussion
2.3
10.0
86
412
F94.9
ICD-10 Finland
Childhood disorder of social functioning, unspecified
40.5
10.0
12
*
K59.09
ICD-10 Finland
Constipation, unspecified
3.1
9.9
43
146
N06AX21
ATC
duloxetine; oral
2.9
9.9
48
174
N06AX11
ATC
mirtazapine; oral
2.0
9.9
122
674
ZYB05
NOMESCO Finland
Outreach service at patient’s workplace, school or occupational/school health care
20.3
9.8
14
7
G40.89
ICD-10 Finland
Other epilepsy
20.3
9.8
14
7
F91.3
ICD-10 Finland
Oppositional defiant disorder
20.3
9.8
14
7
RT160, ,
NOMESCO Finland
10.8
9.8
18
17
H50.30
ICD-10 Finland
Intermittent esotropy
5.2
9.8
20
39
IEP01
NOMESCO Finland
Psychoeducation, family
7.5
9.7
22
30
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.1
9.7
42
143
XA820, ,
NOMESCO Finland
13.6
9.7
16
12
ZYY01
NOMESCO Finland
Contact between professionals
13.6
9.7
16
12
IBB03
NOMESCO Finland
Assessment of vocational rehabilitation needs in a mental health context
13.6
9.7
16
12
P24
ICPC
Specific learning problem
3.6
9.6
32
92
Z07
ICPC
Education problem
4.3
9.6
25
60
SPAT1396
SPAT
Meeting with multidisciplinary group of experts
4.0
9.5
27
69
ZXY49
NOMESCO Finland
Other health care provider
9.2
9.5
19
21
A06AC01
ATC
ispaghula (psylla seeds); oral
2.5
9.4
61
257
A28
ICPC
Limited function/disability NOS
3.0
9.4
43
151
RL720, ,
NOMESCO Finland
+∞
9.4
9
*
F84.3
ICD-10 Finland
Other childhood disintegrative disorder
+∞
9.4
9
*
3153A
ICD-9 Finland
Specific delays in development, Developmental speech or language disorder[KIELENKEHITYKSEN ERITYISVAIKEUS]
+∞
9.4
9
*
ZXY52
NOMESCO Finland
2-person team, doctor-psychologist
12.5
9.3
16
13
R1260
NOMESCO Finland
Evaluation of communicative skills
8.2
9.3
20
25
F21
ICD-10 Finland
Schizotypal disorder
21.9
9.3
13
6
F81.9
ICD-10 Finland
Developmental disorder of scholastic skills, unspecified
21.9
9.3
13
6
Z61.8
ICD-10 Finland
Other negative life events in childhood
13.9
9.2
15
11
F90.1
ICD-10 Finland
Hyperkinetic conduct disorder
37.0
9.0
11
*
N05AE05
ATC
lurasidone; oral
18.8
8.9
13
7
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
8.8
144
873
T07
ICPC
Weight gain
4.6
8.8
21
47
N03AF01
ATC
carbamazepine; oral, rectal
7.3
8.7
20
28
F33.00
ICD-10 Finland
Recurrent depression, mild episode without somatic syndrome
4.2
8.7
23
56
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.0
8.6
99
531
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
3.8
8.6
26
70
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
7.1
8.5
20
29
RS214, ,
NOMESCO Finland
16.5
8.5
13
8
Z72.8
ICD-10 Finland
Other problems related to lifestyle
10.2
8.5
16
16
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.9
8.5
40
143
ZXY54
NOMESCO Finland
2-person team, doctor-occupational therapist
90.5
8.4
9
*
ZXY85
NOMESCO Finland
Other special worker in multidisciplinary team
90.5
8.4
9
*
R1250
NOMESCO Finland
Evaluation of functional capability
8.0
8.4
18
23
F84.11
ICD-10 Finland
Autism with atypical symptoms
+∞
8.3
8
*
3153X
ICD-9 Finland
Specific delays in development, Developmental speech or language disorder[PUHEEN KEHITYKSEN ERITYISVAIKEUS]
+∞
8.3
8
*
DFF20
NOMESCO Finland
Audiometry for children
4.5
8.3
20
45
F64.9
ICD-10 Finland
Gender identity disorder, unspecified
9.6
8.3
16
17
P74
ICPC
Anxiety disorder/anxiety state
2.6
8.2
49
198
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
3.2
8.2
32
102
OAA43, ,
SPAT
2.9
8.2
39
140
RT190, ,
NOMESCO Finland
14.6
8.2
13
9
Z63.5
ICD-10 Finland
Disruption of family by separation and divorce
8.2
8.1
17
21
R4170
NOMESCO Finland
Therapy forms involving educational rehabilitation
33.6
8.1
10
*
ZYA02
NOMESCO Finland
Contact at day ward in specialised medical care or in other intensive outpatient care setting
33.6
8.1
10
*
IBZ02
NOMESCO Finland
Somatic assessment of psychiatric patient
10.2
8.0
15
15
RT130, ,
NOMESCO Finland
22.2
8.0
11
5
F33.1
ICD-10 Finland
Recurrent depressive disorder, current episode moderate
3.7
8.0
25
69
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.2
7.9
69
332
G47.3
ICD-10 Finland
Sleep apnoea
2.4
7.9
58
259
F92.0
ICD-10 Finland
Depressive conduct disorder
13.2
7.9
13
10
H52.1
ICD-10 Finland
Myopia
2.9
7.8
38
138
N06AX03
ATC
mianserin; oral
4.7
7.8
18
39
R1220
NOMESCO Finland
Psychological examination of need and possibilities to rehabilitation
3.7
7.8
25
70
ZXY61
NOMESCO Finland
2-person team, special workers
10.9
7.8
14
13
H60.9
ICD-10 Finland
Otitis externa, unspecified
2.5
7.7
52
223
F93.80
ICD-10 Finland
Generalized anxiety in the bardom age
15.1
7.7
12
8
F71.1
ICD-10 Finland
Moderate mental retardation, significant impairment of behaviour requiring attention or treatment
45.2
7.7
9
*
F94.8
ICD-10 Finland
Other childhood disorders of social functioning
45.2
7.7
9
*
N03AX16
ATC
[U] pregabalin
2.4
7.7
57
256
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.6
7.6
46
187
ZXE00
NOMESCO Finland
One hour or less
1.7
7.6
189
1287
ZXY58
NOMESCO Finland
2-person team, nurse-occupational therapist
25.2
7.6
10
*
K03.66
ICD-10 Finland
Tooth plaque
2.1
7.5
83
437
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.8
7.5
38
141
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
10.1
7.5
14
14
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.0
7.5
34
119
N06BA09
ATC
atomoxetine; oral
7.2
7.5
17
24
IAB01
NOMESCO Finland
Psychiatric pharmacotherapy consultation
7.2
7.5
17
24
E66.00
ICD-10 Finland
Metabolic syndrome
3.9
7.5
22
58
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.6
7.5
43
171
IEP02
NOMESCO Finland
Child-centred family therapy
3.3
7.3
27
83
R4110
NOMESCO Finland
Physiotherapy
1.8
7.3
120
722
F84.10
ICD-10 Finland
Autism in atypical age
+∞
7.3
7
*
2999A
ICD-9 Finland
Psychoses with origin specific to childhood, Unspecified[LAPSUUDEN LAAJA-AL.KEHITYSHÄIR,NUD,TÄYDEL OIREYHTYM]
+∞
7.3
7
*
N05AL05
ATC
amisulpride; oral
+∞
7.3
7
*
F33.8
ICD-10 Finland
Other recurrent depressive disorders
9.5
7.3
14
15
F20.8
ICD-10 Finland
Other schizophrenia
15.8
7.2
11
7
WYA30, ,
SPAT
7.4
7.2
16
22
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.9
7.2
34
122
SPAT1215
SPAT
Assessment of need for medical rehabilitation
3.7
7.1
22
60
H53.0
ICD-10 Finland
Amblyopia ex anopsia
3.7
7.1
22
60
ZXY59
NOMESCO Finland
2-person team, nurse-other special worker
30.1
7.1
9
*
N05AF05
ATC
zuclopenthixol; systemic
20.1
7.1
10
5
ZXY84
NOMESCO Finland
Occupational therapist in multidisciplinary team
20.1
7.1
10
5
Z03
ICPC
Housing/neighbourhood problem
20.1
7.1
10
5
P01
ICPC
Feeling anxious/nervous/tense
1.8
7.0
129
803
F43.1
ICD-10 Finland
Post-traumatic stress disorder
3.1
7.0
29
96
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
7.1
7.0
16
23
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
5.5
6.9
19
35
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
7.6
6.9
15
20
RS110, ,
NOMESCO Finland
13.9
6.9
11
8
S21
ICPC
Skin texture symptom/complaint
2.1
6.9
73
379
F41.1
ICD-10 Finland
Generalized anxiety disorder
2.3
6.8
52
236
N04AA02
ATC
biperiden; systemic
9.4
6.8
13
14
IAB13
NOMESCO Finland
Psychiatric sleep disorder consultation
40.2
6.7
8
*
IAB11
NOMESCO Finland
Psychiatric mood consultation
40.2
6.7
8
*
F84
ICD-10 Finland
Pervasive developmental disorders
40.2
6.7
8
*
IER02, ,
SPAT
22.6
6.7
9
*
T82
ICPC
Obesity
3.5
6.6
23
68
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.8
6.6
112
679
P03
ICPC
Feeling depressed
1.9
6.6
91
518
Z13.88
ICD-10 Finland
Special screening examination for other specified diseases and disorders
2.0
6.6
73
385
SPAT1229
SPAT
Assessment of need for aid
4.1
6.6
18
45
F42
ICD-10 Finland
Obsessive-compulsive disorder
10.1
6.5
12
12
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.4
6.5
23
69
SPAT1365
SPAT
Health check-up performed during first study year due to special need in students of upper secondary schools or vocational schools
6.9
6.5
15
22
F42.1
ICD-10 Finland
Predominantly compulsive acts [obsessional rituals]
6.2
6.5
16
26
R53
ICD-10 Finland
Malaise and fatigue
1.8
6.4
102
606
IBZ01, ,
SPAT
69.9
6.4
7
*
F90.8
ICD-10 Finland
Other hyperkinetic disorders
14.4
6.4
10
7
R25.1
ICD-10 Finland
Tremor, unspecified
6.6
6.3
15
23
IAB07
NOMESCO Finland
Consultation concerning a patient with self-harm intention
8.2
6.3
13
16
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
6.0
6.3
16
27
A04
ICPC
Weakness/tiredness general
1.9
6.3
87
495
SPAT1298
SPAT
Other function in accordance with nutritional therapy nomenclature
9.3
6.3
12
13
IEY06
NOMESCO Finland
Psychiatric treatment and rehabilitation coaching
9.3
6.3
12
13
ZYB06
NOMESCO Finland
Outreach service in patient's nursery
+∞
6.2
6
*
F93.2
ICD-10 Finland
Social anxiety disorder of childhood
+∞
6.2
6
*
2999B
ICD-9 Finland
Psychoses with origin specific to childhood, Unspecified[LAPSUUDEN LAAJA-ALAINEN KEHITYSHÄIRIÖ NUD,JÄLKITILA]
+∞
6.2
6
*
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.3
6.1
47
214
F32
ICD-10 Finland
Depressive episode
2.6
6.1
36
145
P27
ICPC
Fear of mental disorder
3.6
6.1
20
57
IAB08
NOMESCO Finland
Consultation concerning a patient who has attempted suicide
12.6
6.1
10
8
OAA80, ,
SPAT
0.2
6.0
8
319
R4110, ,
SPAT
2.8
6.0
29
105
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
4.2
6.0
16
39
ZXY53
NOMESCO Finland
2-person team, doctor-social worker
10.1
6.0
11
11
ICC03
NOMESCO Finland
Psychiatric treatment plan, transfer to psychiatric ward
10.1
6.0
11
11

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
34
37
9.67
28.19
19.9
26.2
1354.59
1354.27
nmol/l
0.00
34
37
47
77
6.55
27.63
6.1
5.4
404.02
389.65
umol/l
0.23
42
71
83
231
4.05
26.46
1.9
1.6
482.00
293.75
mu/l
2.59
76
213
170
760
2.83
24.94
1.9
1.6
100.02
97.38
pmol/l
0.33
91
396
277
1607
2.56
23.60
5.9
10.9
1.23
1.23
mmol/l
0.74
249
1472
266
1517
2.55
23.46
5.8
11.5
1.23
1.23
mmol/l
0.70
250
1440
175
839
2.62
21.93
2.6
2.9
2.39
2.39
mmol/l
0.18
160
759
426
3121
3.21
21.60
5.7
3.9
1.92
1.91
mu/l
0.09
410
2932
152
697
2.65
20.68
3.2
4.2
7.39
7.39
ph
0.00
25
113
383
2698
2.66
20.08
4.9
3.4
14.21
14.50
pmol/l
1.45
364
2473
451
3477
3.60
19.68
12.8
11.3
139.69
139.42
mmol/l
2.05
444
3377
451
3477
3.60
19.68
12.7
11.3
3.88
3.94
mmol/l
4.36
443
3357
73
228
3.53
19.48
1.6
1.6
901.46
1080.63
nmol/l
1.03
51
181
232
1347
2.30
18.35
2.8
3.2
67.87
68.77
nmol/l
0.20
212
1272
266
1635
2.28
18.34
3.5
2.3
—
—
—
0
0
72
242
3.26
17.04
3.0
2.9
—
—
—
0
0
132
619
2.50
16.73
3.6
2.4
241.40
477.55
u/l
0.96
124
602
103
429
2.73
16.62
1.8
1.3
17.98
19.42
nmol/l
0.58
96
376
348
2511
2.19
14.66
4.5
2.5
5.68
5.50
mmol/l
1.38
326
2305
313
2185
2.09
14.16
5.9
6.0
106.35
103.28
u/l
0.24
292
2054
188
1093
2.12
13.92
4.2
4.1
29.92
33.83
u/l
1.43
180
1040
450
3744
2.70
11.72
9.6
8.1
30.09
28.23
u/l
0.76
439
3632
182
1101
1.99
11.68
4.0
7.8
38.11
37.93
g/l
0.14
164
1057
271
1935
1.83
10.00
5.4
6.7
6.06
6.22
mmol/l
0.60
253
1792
121
689
1.97
8.91
1.6
1.8
1.36
1.35
mmol/l
0.03
109
622
146
898
1.85
8.46
4.0
4.5
8.70
8.70
mmol/l
0.00
124
837
124
726
1.91
8.36
2.8
3.2
607.93
585.88
mosm/kgh2o
0.39
107
632
185
1234
1.76
8.13
7.8
8.1
—
—
—
0
0
435
3721
2.11
7.99
18.1
13.8
14.01
13.45
%
1.60
429
3669
75
372
2.17
7.96
4.4
3.1
—
—
—
0
0
342
2715
1.76
7.93
4.0
2.9
2.83
2.77
mmol/l
0.61
317
2565
275
2059
1.70
7.87
7.7
8.6
0.64
0.63
%
0.21
257
1970
65
306
2.26
7.83
1.7
1.5
423.50
23929017.59
pmol/l
0.50
52
280
342
2726
1.74
7.70
4.0
2.9
4.46
4.51
mmol/l
0.46
323
2603
275
2067
1.69
7.69
9.4
10.0
0.00
0.00
e9/l
0.80
208
1587
90
488
2.00
7.53
3.6
2.6
—
—
—
0
0
337
2696
1.71
7.26
3.9
2.8
1.28
1.39
mmol/l
6.33
316
2563
30
100
3.09
7.17
1.1
1.3
—
—
—
0
0
13
13
10.11
7.02
2.3
2.1
20.81
14.60
umol/l
0.79
13
13
194
1355
1.67
6.98
4.8
6.8
18.61
19.70
umol/l
0.13
181
1260
13
487
0.24
6.85
1.1
1.2
—
—
—
0
0
276
2115
1.64
6.85
7.7
8.5
2.85
3.20
%
1.51
255
2022
66
330
2.12
6.85
2.3
2.3
8.14
12.14
nmol/l
2.93
56
300
278
2135
1.64
6.83
7.8
8.6
8.02
8.32
%
1.22
260
2045
281
2174
1.63
6.62
7.4
8.4
0.04
0.04
e9/l
0.18
228
1829
287
2233
1.63
6.60
8.5
9.3
0.19
0.21
e9/l
1.25
239
1915
319
2551
1.64
6.54
3.5
2.7
1.31
1.17
mmol/l
1.93
297
2424
164
1116
1.67
6.41
3.8
4.0
21.55
44.50
e6/l
1.26
119
852
61
307
2.10
6.22
2.1
2.1
2.39
2.41
mmol/l
1.05
50
260
17
32
5.40
6.14
2.5
2.5
37341.18
41746.87
ug/l
0.46
17
32
279
2179
1.59
6.14
7.5
8.4
0.57
0.57
e9/l
0.03
228
1835
303
2414
1.60
6.12
13.9
10.4
3.67
3.65
e9/l
0.04
254
2029
22
67
3.35
6.09
1.4
2.4
—
—
—
0
0
153
1035
1.66
6.07
3.7
3.8
0.41
0.27
e6/l
0.45
111
783
264
2041
1.58
6.02
7.3
9.0
—
—
—
0
0
288
2283
1.57
5.81
4.7
3.6
32.05
31.63
u/l
0.07
278
2199
287
2276
1.57
5.76
7.4
8.3
2.34
2.30
e9/l
0.24
242
1977
152
1043
1.63
5.64
3.6
3.8
—
—
—
0
0
57
291
2.06
5.60
2.1
2.1
7.01
5.84
u/l
0.45
38
196
183
1319
1.58
5.52
4.6
4.7
21.45
57.79
e6/l
1.16
123
891
283
2255
1.55
5.43
7.8
8.2
34.26
34.52
%
0.15
265
2170
278
2210
1.54
5.36
7.7
8.1
50.72
50.49
%
0.11
258
2127
286
2290
1.54
5.32
5.2
3.5
36.70
36.94
mmol/mol
0.14
262
2181
56
290
2.02
5.30
1.9
2.0
13.56
12.01
iu/l
0.16
38
199
76
437
1.85
5.29
2.9
2.3
—
—
—
0
0
17
48
3.59
5.27
5.0
3.3
1.65
1.77
mmol/l
0.17
17
48
20
64
3.18
5.14
6.3
8.6
1.70
2.38
mmol/l
0.61
12
33
119
785
1.65
5.11
2.8
2.8
52.90
58.10
u/l
0.89
109
738
101
640
1.70
5.04
3.4
3.5
1.65
1.71
e6/l
0.05
47
365
58
311
1.95
4.98
2.1
2.4
24.43
33.16
u/l
2.16
49
254
73
424
1.82
4.91
3.0
3.9
387.89
113.59
mg/l
0.43
45
321
128
870
1.61
4.85
2.1
3.2
2.42
2.68
mg/l
0.85
110
772
18
58
3.15
4.59
4.8
3.9
18.46
18.24
%
—
7
34
12
22
5.50
4.58
7.3
4.2
318.00
248.45
umol/l
—
7
11
7
5
14.01
4.56
7.1
14.0
—
—
—
0
0
110
733
1.62
4.49
2.7
3.2
7.84
6.20
e6/l
0.52
98
650
83
522
1.68
4.23
3.3
2.2
—
—
—
0
0
74
1124
0.59
4.23
1.6
1.8
—
—
—
0
0
104
695
1.60
4.18
3.8
9.4
1.08
1.17
mmol/l
0.12
84
533
34
160
2.18
4.14
3.2
4.1
—
—
—
0
0
102
683
1.60
4.06
4.6
10.0
1.23
1.32
mmol/l
1.75
95
650
98
1373
0.64
3.94
2.7
2.2
—
—
—
0
0
12
27
4.48
3.91
1.8
2.9
—
—
—
0
0
71
438
1.70
3.89
2.1
5.5
5.91
7.48
umol/l
0.37
55
357
86
560
1.62
3.83
3.2
2.1
—
—
—
0
0
54
310
1.81
3.79
3.2
12.1
106.11
104.83
mmol/l
0.90
54
310
86
562
1.62
3.78
3.2
2.1
—
—
—
0
0
86
564
1.61
3.72
3.2
2.2
—
—
—
0
0
70
437
1.68
3.67
2.1
2.8
2.56
2.53
g/l
0.15
60
414
8
12
6.68
3.65
1.1
1.1
—
—
—
0
0
8
12
6.68
3.65
1.0
3.1
—
—
—
0
0
93
634
1.55
3.41
4.5
10.2
—
—
—
0
0
74
478
1.62
3.40
2.2
2.8
14.98
14.15
umol/l
0.36
67
458
8
14
5.72
3.32
1.0
1.5
—
—
—
0
0
436
3983
1.60
3.29
11.1
8.0
—
—
—
0
0
83
556
1.57
3.28
3.2
2.0
—
—
—
0
0
54
837
0.59
3.27
2.2
1.9
—
—
—
0
0
483
4545
2.12
3.22
21.2
14.8
273.42
265.13
e9/l
2.11
465
4375
54
326
1.71
3.21
1.3
1.3
153.69
147.03
iu/ml
0.03
13
116
483
4551
2.09
3.10
21.1
14.7
86.48
87.02
fl
1.44
477
4495
124
916
1.45
3.07
5.1
5.8
1.04
1.09
inr
1.23
46
281
483
4553
2.08
3.06
21.1
14.7
29.01
29.29
pg
2.42
477
4497
483
4553
2.08
3.06
21.1
14.7
4.76
4.68
e12/l
3.48
461
4370
483
4556
2.06
3.01
21.5
14.9
137.46
136.48
g/l
0.78
478
4501
67
436
1.60
3.00
3.8
4.6
1.06
50.93
mg/mmol
0.82
38
321
25
123
2.06
2.78
1.1
1.3
—
—
—
0
0
53
335
1.63
2.68
1.5
1.9
—
—
—
0
0
481
4549
1.92
2.67
21.2
15.4
40.53
41.43
%
0.41
460
4379
27
140
1.96
2.62
1.7
1.7
—
—
—
0
0
17
73
2.35
2.61
2.5
1.4
—
—
—
0
0
481
4556
1.89
2.55
21.3
14.8
6.94
6.95
e9/l
0.03
461
4372
16
68
2.37
2.52
3.5
6.4
—
—
—
0
0
12
278
0.41
2.50
1.5
1.3
—
—
—
0
0
61
407
1.55
2.47
2.2
3.0
25.00
23.11
%
0.38
55
381
19
89
2.15
2.41
1.4
1.6
0.22
0.32
nmol/l
0.60
14
73
90
658
1.43
2.34
3.7
4.1
—
—
—
0
0
425
3932
1.43
2.29
11.6
10.2
20.76
22.47
mg/l
0.47
300
2727
183
1504
1.32
2.28
1.7
1.7
0.83
3.32
u/ml
3.12
34
288
101
1282
0.72
2.22
1.5
1.7
—
—
—
0
0
5
9
5.53
2.20
2.4
1.3
112.20
63.44
nmol/24h
—
5
9
39
241
1.65
2.18
2.1
2.7
0.75
1.30
ug/l
1.47
30
221
279
2444
1.29
2.10
4.0
3.9
6.90
7.53
mm/h
0.65
265
2288
263
2293
1.28
2.03
4.3
3.9
—
—
—
0
0
18
89
2.04
2.02
1.7
1.3
357.00
366.36
ug/g
—
10
48
25
139
1.82
2.02
2.0
13.9
0.70
0.63
%
0.58
25
139
95
725
1.36
1.93
2.5
2.4
—
—
—
0
0
5
11
4.53
1.92
1.0
1.5
—
—
—
0
0
209
1780
1.27
1.92
2.9
3.1
61.69
66.77
ug/l
0.23
187
1681
21
113
1.87
1.88
1.1
1.1
—
—
—
0
0
23
129
1.80
1.82
1.4
1.1
—
—
—
0
0
85
646
1.36
1.77
1.2
1.2
—
—
—
0
0
21
116
1.82
1.75
5.6
7.9
25.10
24.31
mmol/l
0.63
21
110
8
30
2.66
1.70
1.0
1.3
—
—
—
0
0
13
61
2.14
1.68
1.5
1.5
3.94
12.68
u/l
2.69
13
54
66
488
1.39
1.63
2.8
3.2
69.00
1409.17
ng/l
3.69
30
261
118
1408
0.78
1.62
2.2
3.0
—
—
—
0
0
5
14
3.56
1.60
4.4
2.7
—
—
—
0
0
9
181
0.48
1.54
1.7
1.5
—
—
—
0
0
77
964
0.75
1.51
1.9
1.7
—
—
—
0
0
0
45
0.00
1.49
0.0
2.6
—
—
—
0
0
0
45
0.00
1.49
0.0
5.3
—
—
—
0
0
15
79
1.90
1.46
1.1
1.1
—
—
—
0
0
14
72
1.95
1.46
1.0
1.1
—
—
—
0
0
5
16
3.11
1.42
2.0
2.6
108.00
105.94
mmol/l
—
5
16
5
16
3.11
1.42
2.0
2.6
4.04
3.82
mmol/l
—
5
16
5
16
3.11
1.42
2.0
2.6
—
—
—
0
0
81
998
0.77
1.41
1.7
1.7
—
—
—
0
0
12
221
0.53
1.41
1.0
1.1
—
—
—
0
0
164
1405
1.23
1.35
1.6
1.6
1.65
1.75
g/l
0.33
69
741
0
38
0.00
1.34
0.0
1.0
—
—
—
0
0
0
38
0.00
1.34
0.0
1.1
—
—
—
0
0
91
729
1.29
1.33
3.9
3.0
1.02
1.02
kg/l
1.10
11
117
18
105
1.72
1.30
1.9
3.8
—
—
—
0
0
158
1354
1.22
1.29
3.8
3.0
6.39
6.10
ph
0.67
14
167
28
185
1.53
1.26
1.3
1.1
—
—
—
0
0
6
25
2.39
1.23
1.8
1.8
8.83
9.92
umol/l
—
6
25
7
143
0.48
1.22
1.0
1.4
—
—
—
0
0
7
143
0.48
1.22
1.0
1.4
—
—
—
0
0
5
19
2.62
1.20
1.4
1.6
77.80
73.68
umol/l
—
5
19
21
316
0.64
1.18
1.0
1.2
0.99
2.63
u/ml
1.11
13
242
12
208
0.56
1.18
2.1
1.9
—
—
—
0
0
6
26
2.30
1.17
1.0
1.3
—
—
nmol/l
—
0
0
83
994
0.79
1.16
2.4
2.9
—
—
—
0
0
5
21
2.37
1.08
1.2
1.0
—
—
—
0
0
11
188
0.57
1.04
1.2
1.1
—
4.29
—
0
7
0
28
0.00
0.98
0.0
3.2
—
—
—
0
0
12
68
1.76
0.98
5.0
6.0
1.99
1.87
ug/l
0.08
12
68
0
29
0.00
0.98
0.0
1.2
—
240.15
—
0
29
9
50
1.79
0.96
1.4
1.3
193.56
43.22
pmol/l
—
9
50
8
144
0.54
0.94
1.4
1.5
—
10.22
—
0
6
6
27
2.21
0.93
1.0
1.1
—
—
—
0
0
32
234
1.38
0.91
4.5
5.1
0.00
0.04
%
—
10
84
23
316
0.71
0.86
1.0
1.3
0.63
0.75
u/ml
0.06
13
230
80
668
1.22
0.85
1.7
3.7
0.68
1.57
mg/l
1.71
57
466
32
237
1.36
0.85
1.2
1.2
—
33.58
—
0
9
6
31
1.92
0.83
1.3
1.2
—
—
—
0
0
6
114
0.51
0.83
1.0
1.2
—
—
—
0
0
14
88
1.59
0.82
1.4
18.6
—
—
—
0
0
9
147
0.60
0.80
1.2
1.5
—
—
—
0
0
11
65
1.69
0.80
4.1
6.5
—
—
—
0
0
0
25
0.00
0.79
0.0
1.8
—
—
—
0
0
26
344
0.73
0.79
1.0
1.3
2.30
2.96
u/ml
0.18
18
255
60
491
1.24
0.78
1.4
1.5
312.73
403.04
titre
0.36
11
79
96
824
1.19
0.77
3.2
3.1
—
—
—
0
0
17
114
1.49
0.77
1.2
1.6
—
—
—
0
0
5
23
2.16
0.76
3.2
3.5
1932.00
514.30
u/ml
—
5
23
21
148
1.42
0.75
3.0
3.7
52.75
171.06
ng/l
2.71
16
126
12
182
0.64
0.75
1.0
1.1
0.01
0.36
u/ml
—
6
93
5
24
2.07
0.74
1.4
1.5
—
—
—
0
0
11
169
0.64
0.73
1.3
1.1
—
—
—
0
0
32
244
1.32
0.73
4.7
5.0
0.20
0.58
%
—
10
95
88
995
0.85
0.70
2.3
1.9
—
—
—
0
0
35
272
1.29
0.70
3.1
3.7
—
—
—
0
0
30
228
1.32
0.70
4.5
4.6
0.09
0.49
%
1.57
11
87
7
42
1.66
0.68
1.3
1.8
—
—
—
0
0
5
94
0.52
0.67
3.0
1.4
—
—
—
0
0
10
61
1.63
0.66
1.0
1.3
—
—
—
0
0
25
321
0.76
0.64
1.0
1.2
1.11
6.86
u/ml
6.50
16
251
7
44
1.58
0.64
1.6
1.6
—
—
—
0
0
10
62
1.61
0.63
1.0
1.3
5.40
6.11
g/l
—
10
50
10
62
1.61
0.63
1.0
1.3
0.25
0.40
g/l
—
10
49
10
62
1.61
0.63
1.0
1.3
1.90
2.27
g/l
—
10
49
18
129
1.39
0.61
1.7
1.9
0.35
0.60
ug/l
—
9
52
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
6
34
1.75
0.58
1.0
1.1
—
—
—
0
0
28
218
1.29
0.57
1.2
1.2
—
—
—
0
0
6
37
1.61
0.55
1.7
1.9
—
—
—
0
0
16
115
1.39
0.54
1.1
1.1
—
—
—
0
0
6
38
1.57
0.54
1.2
1.4
172.58
236.87
pmol/l
—
6
38
53
448
1.19
0.53
1.4
1.2
12.40
19.71
iu/ml
—
10
112
9
61
1.47
0.53
2.8
13.2
0.79
0.88
%
—
9
52
9
62
1.44
0.52
2.8
13.5
1.88
1.43
%
—
9
51
23
177
1.30
0.52
4.9
8.5
0.21
0.35
g/l
0.81
15
140
6
40
1.49
0.51
1.8
2.3
—
—
—
0
0
76
845
0.87
0.51
3.1
2.9
—
—
—
0
0
29
352
0.80
0.50
1.4
1.3
—
—
—
0
0
11
75
1.46
0.48
1.2
4.5
3.90
3.52
e9/l
0.33
11
75
11
75
1.46
0.48
1.5
3.1
138.09
139.82
g/l
0.12
11
60
28
224
1.25
0.48
1.3
1.2
—
—
—
0
0
39
325
1.20
0.47
3.7
2.6
3168.80
4560.86
u/l
—
10
125
16
207
0.76
0.46
1.0
1.1
1.52
6.47
u/ml
—
10
144
11
76
1.44
0.46
1.3
4.9
55.73
51.67
%
0.62
11
76
18
137
1.31
0.45
5.5
17.4
—
—
—
0
0
68
601
1.14
0.41
8.0
8.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.9
—
—
—
0
0
14
104
1.34
0.41
2.6
2.4
—
—
—
0
0
5
33
1.50
0.41
1.0
1.1
—
—
—
0
0
12
87
1.37
0.40
1.4
19.8
64.75
73.43
%
0.74
12
87
16
122
1.31
0.40
2.3
2.7
49.61
22.66
mu/l
0.41
16
116
5
34
1.46
0.40
1.2
1.1
—
—
—
0
0
7
101
0.68
0.40
2.9
1.5
—
—
—
0
0
0
18
0.00
0.40
0.0
3.4
—
—
—
0
0
21
167
1.25
0.39
4.8
14.7
121.95
124.51
g/l
0.24
21
158
5
35
1.42
0.39
1.2
1.1
—
—
—
0
0
9
68
1.31
0.37
2.3
4.4
—
—
—
0
0
35
401
0.85
0.36
1.6
2.1
—
—
—
0
0
21
169
1.24
0.36
1.2
1.3
—
—
—
0
0
9
70
1.28
0.36
1.0
1.0
1.40
1.37
g/l
—
9
65
6
41
1.45
0.36
1.3
1.0
—
—
—
0
0
12
90
1.33
0.34
2.3
5.8
—
—
—
0
0
6
45
1.32
0.33
1.8
5.4
—
—
—
0
0
16
196
0.80
0.33
1.3
1.6
—
—
—
0
0
26
218
1.19
0.32
4.8
13.6
5.17
5.26
kpa
0.24
26
205
26
218
1.19
0.32
4.8
13.6
-0.01
0.55
mmol/l
0.29
20
174
26
218
1.19
0.32
4.8
13.6
12.33
15.64
kpa
2.73
26
205
8
107
0.74
0.29
1.1
1.1
0.20
2.41
u/ml
—
8
69
15
182
0.81
0.29
1.3
1.5
—
—
—
0
0
169
1595
1.07
0.29
3.4
3.3
0.00
0.00
estimate
-0.00
35
302
27
230
1.17
0.28
4.9
5.2
0.00
0.03
%
—
6
77
15
120
1.24
0.28
2.2
4.6
—
—
—
0
0
36
401
0.88
0.28
1.6
1.5
—
—
—
0
0
42
462
0.89
0.27
1.6
1.7
—
—
—
0
0
8
66
1.20
0.26
1.4
23.5
12.97
12.28
%
—
8
66
10
76
1.31
0.26
3.1
7.7
—
—
—
0
0
13
158
0.81
0.26
1.2
1.2
—
—
—
0
0
13
157
0.81
0.24
1.2
1.2
—
—
—
0
0
33
290
1.13
0.24
1.2
1.2
—
—
—
0
0
65
595
1.09
0.24
8.6
8.8
9.66
9.70
kpa
0.07
65
579
167
1587
1.06
0.23
5.0
4.7
0.00
0.00
estimate
-0.00
35
317
70
645
1.09
0.23
4.6
2.3
14.14
63.75
ng/l
0.86
34
263
5
40
1.24
0.22
1.4
1.1
182.60
249.85
mg/l
—
5
35
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
2.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
10.8
—
—
—
0
0
23
199
1.15
0.21
5.1
14.7
93.81
95.87
%
0.24
23
187
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.20
0.0
1.1
—
—
—
0
0
12
143
0.83
0.20
3.4
2.9
—
—
—
0
0
16
185
0.85
0.20
1.0
1.2
2.05
10.48
u/ml
—
10
119
54
495
1.09
0.20
1.6
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
1794.29
—
0
14
6
51
1.17
0.19
1.8
5.0
—
—
—
0
0
6
52
1.14
0.19
1.0
1.4
—
280.77
—
0
13
12
99
1.20
0.18
2.7
2.1
—
—
—
0
0
5
66
0.75
0.17
2.6
1.8
—
—
—
0
0
8
68
1.17
0.16
8.3
8.6
—
—
—
0
0
34
311
1.09
0.14
1.2
1.3
—
—
—
0
0
13
111
1.16
0.14
2.1
1.7
—
—
—
0
0
46
427
1.07
0.14
1.3
1.2
30.33
5.33
u/ml
—
8
161
165
1589
1.04
0.14
3.4
3.2
0.00
0.00
estimate
-0.00
34
314
28
301
0.92
0.13
2.9
4.9
61.82
63.23
e9/l
0.10
17
182
10
84
1.18
0.12
2.2
9.7
—
—
—
0
0
47
439
1.06
0.12
7.0
12.4
5.13
5.60
mmol/l
0.44
47
428
46
479
0.94
0.10
2.6
3.9
314.23
1844.72
umol/l
0.80
39
446
42
437
0.95
0.09
4.8
6.3
1.38
1.41
%
0.13
37
417
6
53
1.12
0.09
1.0
1.7
—
—
—
0
0
6
57
1.04
0.08
1.0
1.1
—
—
—
0
0
7
66
1.05
0.08
3.0
1.8
—
—
—
0
0
14
152
0.91
0.08
2.1
1.5
1.16
1.16
g/l
0.02
14
146
10
111
0.89
0.07
1.4
1.2
—
—
—
0
0
7
79
0.87
0.07
2.1
4.3
—
—
—
0
0
8
89
0.89
0.07
1.1
3.3
42.09
37.49
%
—
8
89
15
137
1.09
0.06
3.5
3.7
0.08
0.13
e6/l
0.28
15
130
79
798
0.98
0.05
3.3
3.4
0.00
0.00
estimate
0.50
32
303
16
148
1.07
0.04
2.1
1.9
—
—
—
0
0
13
122
1.06
0.01
1.7
1.7
—
—
—
0
0
15
146
1.02
0.00
6.3
15.5
95.54
95.83
%
0.14
15
146
26
253
1.02
0.00
1.5
1.5
—
—
—
0
0
28
273
1.02
0.00
1.7
1.9
—
—
—
0
0
15
152
0.98
0.00
1.0
1.0
—
—
—
0
0
81
801
1.00
0.00
1.9
3.4
156.08
125.55
ug/g
0.14
56
645
70
693
1.00
0.00
1.9
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
6.14
—
0
8
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.4
—
—
—
0
0
0
9
0.00
0.00
0.0
9.2
—
—
—
0
0
0
9
0.00
0.00
0.0
3.7
—
0.46
—
0
9
0
9
0.00
0.00
0.0
3.3
—
138.78
—
0
9
0
8
0.00
0.00
0.0
16.8
—
14.00
—
0
8
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
8
79
1.00
0.00
1.1
3.3
27.38
26.71
%
—
8
79
8
82
0.96
0.00
3.0
12.1
23.73
24.18
mmol/l
—
8
72
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
38.16
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
9
89
1.00
-0.00
1.2
3.6
16.00
16.11
%
—
9
89
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
78
1.01
-0.00
5.8
4.8
2.88
10.44
u/ml
—
8
78
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
6.1
—
—
—
0
0
6
59
1.01
-0.00
1.0
4.6
27.50
24.23
umol/l
—
6
59
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
30.03
—
0
6
0
6
0.00
-0.00
0.0
1.5
—
27.50
—
0
6
6
65
0.91
-0.00
1.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
8
84
0.94
-0.00
1.1
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
8
86
0.92
-0.00
1.1
3.3
9.75
9.05
%
—
8
86

Mortality – FinRegistry

↥

Association

Association between endpoint F5_PERVASIVE and mortality.

Females

Parameter HR [95% CI] p-value
F5_PERVASIVE 4.437 [2.83, 6.96] < 0.001
Birth year 0.992 [0.98, 1.0] 0.09

During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 2735 females with F5_PERVASIVE died.

Males

Parameter HR [95% CI] p-value
F5_PERVASIVE 2.447 [1.92, 3.12] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 94 out of 7819 males with F5_PERVASIVE died.

Mortality risk

Mortality risk for people of age

years, who have F5_PERVASIVE.

N-year risk Females Males
1 0.416% 0.596%
5 2.348% 2.963%
10 6.356% 6.658%
15 12.009% 12.015%
20 20.443% 20.517%

Relationships between endpoints

↥

Index endpoint: F5_PERVASIVE – Pervasive developmental disorders excl. Autism + Asperger

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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