No definition available.
Pervasive developmental disorders excl. Autism + Asperger
DOID EFO Endpoint Browser PheWeb
F5_PERVASIVE
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
461 |
4. Check minimum number of eventsNone |
461 |
5. Include endpointsNone |
461 |
6. Filter based on genotype QC (FinnGen only) |
461 |
Control definitions (FinnGen only)
- Control exclude
- F5_PSYCHDEV
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- F80-F89
- Name in latin
- Perturbationes formationales pervasivae (in pueritia)
Similar endpoints
↥List of similar endpoints to Pervasive developmental disorders excl. Autism + Asperger based on the number of shared cases.
Similar with more cases:
- Wide developmental disorders
- Wide developmental disorders, excluding more controls
- Disorders of psychological development
- Any mental disorder
- Psychiatric diseases
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 13185 | 3541 | 9638 |
Only index persons | 10180 | 2894 | 7286 |
Unadjusted period prevalence (%) | |||
Whole population | 0.22 | 0.10 | 0.27 |
Only index persons | 0.23 | 0.11 | 0.28 |
Median age at first event (years) | |||
Whole population | 8.61 | 10.02 | 8.07 |
Only index persons | 10.22 | 11.89 | 9.55 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 461 | 186 | 275 |
Unadjusted period prevalence (%) | 0.10 | 0.06 | 0.12 |
Median age at first event (years) | 12.92 | 16.09 | 10.77 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 401
- Matched controls
- 3995
Mortality – FinRegistry
↥Association
Association between endpoint F5_PERVASIVE and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
F5_PERVASIVE | 4.437 [2.83, 6.96] | < 0.001 |
Birth year | 0.992 [0.98, 1.0] | 0.09 |
During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 2735 females with F5_PERVASIVE died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
F5_PERVASIVE | 2.447 [1.92, 3.12] | < 0.001 |
Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 94 out of 7819 males with F5_PERVASIVE died.
Mortality risk
Mortality risk for people of age
years, who have F5_PERVASIVE.N-year risk | Females | Males |
---|---|---|
1 | 0.416% | 0.596% |
5 | 2.348% | 2.963% |
10 | 6.356% | 6.658% |
15 | 12.009% | 12.015% |
20 | 20.443% | 20.517% |
Relationships between endpoints
↥Index endpoint: F5_PERVASIVE – Pervasive developmental disorders excl. Autism + Asperger
GWS hits: -