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This is a non-core endpoint: only basic statistics are computed.

Benign neoplasm: Carotid body

CD2_BENIGN_CAROTIDBODY_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D35.50&, D35.59&
  • Hospital discharge: ICD-9 2275
  • Cause of death: ICD-10 D35.50&, D35.59&
  • Cause of death: ICD-9 2275

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 98 59 39
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 53.73 52.16 56.13

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
86
Matched controls
859
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D35.59
ICD-10 Finland
Other paragangliom
+∞
72.4
59
*
D35.50
ICD-10 Finland
Carotid body
+∞
40.9
36
*
WX408
NOMESCO Finland
General anesthesy, balanced
8.4
17.4
47
107
BDA10
NOMESCO Finland
Operation on carotid body
+∞
16.1
15
*
H02AB09
ATC
hydrocortisone; systemic
25.5
11.1
15
7
WF002
NOMESCO Finland
Radical radiotherapy
+∞
10.6
10
*
Z31.5
ICD-10 Finland
Genetic counselling
16.0
10.2
16
12
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
+∞
9.5
9
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
9.8
9.5
19
24
XX3DW
NOMESCO Finland
Time consuming IT work
14.8
9.3
15
12
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
27.5
9.2
12
5
102
Kela drug reimbursment
Diabetes insipidus
99.4
8.6
9
*
E23.00
ICD-10 Finland
Panhypopituitarism
99.4
8.6
9
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
99.4
8.6
9
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
37.2
8.3
10
*
JN4BD
NOMESCO Finland
Extensive body CT
11.7
7.9
14
14
116
Kela drug reimbursment
Prostate cancer
+∞
7.4
7
*
JN5ER
NOMESCO Finland
PET-CT of receptors in whole body
+∞
7.4
7
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
7.4
7
*
D35.30
ICD-10 Finland
Craniopharyngoma
+∞
7.4
7
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
7.4
7
*
D35.9
ICD-10 Finland
Benign neoplasm: Endocrine gland, unspecified
+∞
7.4
7
*
E27.5
ICD-10 Finland
Adrenomedullary hyperfunction
+∞
7.4
7
*
8680/3-C75.5
ICD-O-3
Paraganglioma, NOS, of aortic body and other paraganglia
+∞
7.4
7
*
9350/1-C75.2
ICD-O-3
Craniopharyngioma, NOS, of craniopharyngeal duct
+∞
7.4
7
*
L02AE02
ATC
leuprorelin; implant, parenteral
43.6
6.9
8
*
TPH07
NOMESCO Finland
Cathetrisation of artery
6.4
6.6
17
32
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
15.9
6.6
10
7
D14.0
ICD-10 Finland
Benign neoplasm: Middle ear, nasal cavity and accessory sinuses
75.2
6.5
7
*
DCB00
NOMESCO Finland
Excision of lesion of middle ear
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
38
12
51.09
61.16
4.6
1.3
0.2
—
nmol/l
—
13
0
36
10
56.32
59.84
4.5
1.2
—
—
nmol/l
—
0
0
36
10
56.32
59.84
4.5
1.2
—
—
—
0
0
37
6
97.31
35.03
4.6
1.0
2.9
6.1
nmol/l
—
37
6
27
20
18.25
30.04
1.2
1.3
—
—
—
0
0
48
196
3.84
9.84
4.0
3.3
7.4
7.4
ph
0.19
13
26
52
254
3.23
7.58
2.3
1.6
—
—
—
0
0
22
62
4.29
7.37
1.5
1.1
—
—
—
0
0
35
153
3.00
5.93
4.9
4.2
—
—
—
0
0
41
201
2.79
5.58
1.8
2.2
—
—
—
0
0
20
65
3.61
5.43
4.5
17.3
2.0
1.4
mmol/l
0.27
15
54
13
31
4.68
5.27
3.5
20.8
—
—
—
0
0
8
9
9.55
4.36
1.9
1.6
—
—
—
0
0
42
248
2.21
3.52
8.6
9.5
1.2
1.3
inr
0.12
15
61
89
740
3.20
3.44
4.6
4.7
1.7
1.8
mu/l
0.16
82
678
15
55
3.04
3.33
2.6
3.3
—
—
—
0
0
41
247
2.13
3.22
4.3
5.3
—
—
—
0
0
12
40
3.28
3.09
4.8
10.7
24.8
25.5
mmol/l
0.21
12
40
32
181
2.14
2.91
3.8
3.8
0.0
0.0
estimate
0.00
13
59
14
54
2.86
2.85
4.6
12.8
—
—
—
0
0
34
202
2.05
2.69
1.6
1.4
—
—
—
0
0
39
245
1.98
2.64
2.4
2.4
50.4
54.3
u/l
0.42
39
225
19
90
2.38
2.60
1.2
1.2
—
—
—
0
0
27
154
2.04
2.36
3.3
3.4
106.7
108.7
ng/l
0.01
17
110
65
511
1.81
2.00
4.2
3.6
—
—
—
0
0
10
39
2.74
1.99
5.8
13.7
93.8
94.3
%
—
10
39
8
29
2.91
1.83
4.5
28.7
—
—
—
0
0
10
41
2.60
1.82
5.8
13.0
0.4
0.8
%
—
10
41
52
395
1.67
1.71
5.2
5.4
1.7
1.9
e9/l
1.07
44
341
52
400
1.64
1.59
5.2
5.8
0.2
0.2
e9/l
0.26
45
344
31
212
1.68
1.48
2.8
2.9
—
—
—
0
0
31
212
1.68
1.48
3.0
2.8
—
—
—
0
0
50
387
1.60
1.46
4.9
5.2
0.6
0.5
e9/l
0.34
42
324
5
16
3.23
1.45
1.2
1.9
—
—
—
0
0
55
436
1.60
1.45
8.4
7.0
4.5
4.3
e9/l
0.20
49
366
50
388
1.59
1.43
4.9
5.2
0.0
0.0
e9/l
0.39
42
327
49
381
1.57
1.38
3.9
3.3
0.0
0.0
estimate
0.00
13
57
45
345
1.56
1.34
12.0
6.9
0.0
0.0
e9/l
0.00
36
256
64
532
1.59
1.33
4.4
3.9
—
—
—
0
0
17
101
1.83
1.30
1.4
1.5
352.0
567.4
titre
—
5
27
48
376
1.54
1.28
5.3
4.6
0.0
0.0
estimate
0.00
13
62
92
853
2.28
1.28
17.3
9.9
—
—
—
0
0
10
50
2.11
1.21
1.4
1.2
494.3
687.5
u/ml
—
10
45
47
374
1.49
1.13
3.9
3.3
0.0
0.0
estimate
0.00
13
63
8
41
2.03
1.11
6.5
13.1
1.1
1.6
%
—
8
41
5
21
2.45
1.10
4.2
5.1
0.8
1.1
mmol/l
—
5
21
22
149
1.61
1.07
1.5
2.1
—
—
—
0
0
16
100
1.72
1.04
1.5
2.5
—
—
—
0
0
88
811
1.83
1.00
17.2
11.1
23.2
21.4
mg/l
0.21
75
593
35
268
1.48
0.99
3.8
3.1
17.2
34.0
ng/l
1.05
27
163
6
27
2.30
0.95
1.8
1.4
0.2
0.2
g/l
—
6
27
12
71
1.79
0.94
2.0
5.3
—
—
—
0
0
13
79
1.74
0.93
1.3
1.3
—
—
—
0
0
6
28
2.22
0.93
1.8
1.4
1.1
1.1
g/l
—
6
28
14
88
1.69
0.90
2.3
1.7
—
—
—
0
0
38
302
1.42
0.88
3.4
3.1
—
—
—
0
0
0
24
0.00
0.80
0.0
2.4
—
—
—
0
0
0
25
0.00
0.80
0.0
1.6
—
—
—
0
0
5
24
2.14
0.75
1.0
1.1
—
—
—
0
0
5
24
2.14
0.75
3.2
1.5
—
—
—
0
0
28
216
1.41
0.75
3.4
3.2
—
—
—
0
0
24
180
1.44
0.74
6.7
5.6
—
—
—
0
0
9
57
1.64
0.73
3.3
3.2
—
—
—
0
0
9
58
1.61
0.72
1.2
1.3
—
—
—
0
0
5
27
1.90
0.69
3.0
3.7
23.5
25.1
mmol/l
—
5
27
5
27
1.90
0.69
1.2
1.7
23.8
53.5
u/ml
—
5
27
22
165
1.43
0.68
3.3
5.1
—
—
—
0
0
7
44
1.64
0.66
4.6
2.9
5.1
5.2
kpa
—
7
38
8
49
1.69
0.64
4.0
2.9
—
—
—
0
0
0
20
0.00
0.61
0.0
3.2
—
—
—
0
0
16
116
1.45
0.59
2.0
2.5
0.8
0.8
ug/l
—
10
74
6
35
1.76
0.59
2.8
3.7
—
—
—
0
0
77
818
0.73
0.56
4.8
4.7
2.6
2.8
mmol/l
1.40
69
755
75
798
0.74
0.53
4.4
4.3
1.5
1.5
mmol/l
0.29
69
736
9
65
1.42
0.52
2.3
2.0
5.1
6.1
ug/l
—
9
59
7
45
1.60
0.50
1.7
1.1
—
—
—
0
0
13
94
1.44
0.49
1.2
1.4
—
—
—
0
0
16
122
1.37
0.46
1.6
1.6
700.9
1214.9
nmol/l
—
8
91
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
11
81
1.40
0.38
2.0
2.5
1.8
1.5
%
0.81
11
73
18
146
1.29
0.35
1.3
1.3
11.9
21.4
iu/ml
—
10
52
20
167
1.25
0.31
5.7
3.6
1.0
1.0
kg/l
—
6
23
77
803
0.81
0.31
4.5
4.3
4.6
4.7
mmol/l
0.61
70
745
73
765
0.82
0.31
3.9
3.9
1.6
1.3
mmol/l
1.11
68
698
12
94
1.32
0.29
1.6
1.8
—
—
—
0
0
8
66
1.23
0.27
1.1
1.2
—
32.0
—
0
5
10
77
1.33
0.27
1.8
1.4
—
—
—
0
0
78
751
1.19
0.23
6.3
5.3
39.1
39.5
mmol/mol
0.14
72
714
0
11
0.00
0.21
0.0
2.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
2.5
—
4.2
—
0
11
0
11
0.00
0.21
0.0
2.5
—
106.3
—
0
11
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.9
—
—
—
0
0
20
226
0.86
0.20
2.0
1.7
1.4
1.4
mmol/l
0.05
14
197
23
206
1.15
0.18
3.2
2.6
—
—
—
0
0
79
767
1.15
0.17
5.1
4.2
5.9
5.9
mmol/l
0.01
72
703
9
81
1.12
0.15
1.3
1.2
—
—
—
0
0
11
93
1.21
0.15
1.5
1.5
—
—
—
0
0
15
167
0.88
0.11
1.7
1.8
0.6
1.4
mg/l
—
10
124
10
87
1.17
0.10
1.3
1.9
—
—
—
0
0
28
263
1.09
0.10
3.7
3.3
13.4
61.7
e6/l
1.48
23
166
5
47
1.07
0.09
2.2
4.6
—
0.4
—
0
9
5
48
1.04
0.09
2.2
4.4
—
0.0
—
0
9
5
48
1.04
0.09
2.2
4.6
—
0.1
—
0
9
7
67
1.05
0.08
2.1
1.4
—
—
—
0
0
13
120
1.10
0.05
1.5
1.6
—
—
—
0
0
19
181
1.06
0.03
1.5
1.3
3.3
2.7
g/l
—
9
99
13
138
0.93
0.02
1.5
1.3
1.3
11.7
u/ml
—
6
55
22
212
1.05
0.02
3.1
3.0
8.5
66.9
mg/l
—
9
137
22
228
0.95
0.02
3.6
3.7
1.6
9.7
mg/mmol
2.36
11
148
30
292
1.04
0.02
2.0
1.9
94.5
95.0
pmol/l
0.02
15
131
17
177
0.95
0.01
5.3
3.3
—
—
—
0
0
77
768
1.01
0.00
16.3
12.8
39.1
40.5
%
0.63
57
592
31
309
1.00
0.00
3.1
2.9
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.7
—
7.5
—
0
8
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
0.00
5.2
2.2
—
—
—
0
0
0
9
0.00
0.00
0.0
20.0
—
1627.7
—
0
9
5
51
0.98
0.00
2.2
4.4
—
0.5
—
0
10
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
11.7
—
789.6
—
0
9
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
6
59
1.02
0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
88.3
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
8
81
0.99
0.00
1.6
1.9
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
10.4
—
0.6
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_BENIGN_CAROTIDBODY_EXALLC – Benign neoplasm: Carotid body

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).