Benign neoplasm: Extrahepatic bile ducts

CD2_BENIGN_EXTRAHEPATIC_BILE_EXALLC

No definition available.

Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data
1. Apply sex-specific rule None	-
2. Check conditions None
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D13.5& Hospital discharge: ICD-8 — 2115[1-2] Cause of death: ICD-10 — D13.5& Cause of death: ICD-8 — 2115[1-2] 2 out of 7 registries used, show all original rules.	-
4. Check minimum number of events None	-
5. Include endpoints None	-
6. Filter based on genotype QC (FinnGen only) None	-

Control definitions (FinnGen only)

Control exclude: C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D13
Name in latin: Neoplasma benignum ductuum biliarium extrahepaticorum

NAME	CD2_BENIGN_EXTRAHEPATIC_BILE_EXALLC
CONTROL_EXCLUDE	C3_CANCER\|C3_CANCER_WIDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D135
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	2115[1-2]
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D135
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	2115[1-2]
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Benign neoplasm: Extrahepatic bile ducts based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Benign neoplasm: Extrahepatic bile ducts

Case counts by codes

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FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	98	54	44
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	59.65	54.98	65.39

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
90: Matched controls
898

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D13.5

ICD-10 Finland

Benign neoplasm: Extrahepatic bile ducts

+∞

116.9

JKA21

NOMESCO Finland

Laparoscopic cholecystectomy

12.4

21.0

D37.6

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Liver, gallbladder and bile ducts

163.5

13.9

UJK02

NOMESCO Finland

ERCP

40.8

11.6

JKE98

NOMESCO Finland

Other transduodenal endoscopic operation on bile duct or ampulla of Vater

111.1

9.6

JN1CG

NOMESCO Finland

Extensive MRI examination of upper part of abdomen with high intensity magnet

41.2

9.2

JJ1CE

NOMESCO Finland

Liver, bile duct and pancreas endoscopic ultrasound examination

98.8

8.6

D37.7

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Other digestive organs

27.7

7.7

130

Kela drug reimbursment

Malignant tumour

+∞

7.4

JL5SB

NOMESCO Finland

Endoscopic retrograd cholangiopancreaticography

43.4

6.9

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

8.1

6.5

A04AA02

ATC

granisetron; systemic, transdermal

74.9

6.5

K80.2

ICD-10 Finland

Calculus of gallbladder without cholecystitis

4.5

6.2

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

3.1

6.0

196

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

11.47

25.00

2.3

1.1

2.85

2.97

ug/l

0.08

(3002256) Pathology report gross observation

5.06

9.64

1.3

1.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

314

2.95

6.42

4.0

3.4

—

(40768804) Tissue Pathology biopsy report

256

2.50

4.68

2.7

1.5

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

337

2.34

4.12

10.8

5.1

1.22

1.21

mmol/l

0.39

283

(4035726)

4.34

3.80

1.8

1.2

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

415

2.24

3.62

8.6

5.7

4.89

4.32

e9/l

1.00

351

(40768797) Stomach Pathology biopsy report

110

2.57

3.56

1.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.71

3.19

1.6

1.5

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

140

2.28

3.04

2.4

1.9

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

151

2.20

2.86

3.0

1.9

3.13

2.76

mg/l

0.16

127

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

2.97

2.65

2.5

1.8

0.27

0.20

g/l

2.58

(3035350) Ketones [Presence] in Urine by Test strip

353

1.93

2.59

5.1

3.5

0.00

estimate

—

(40768793) Breast Pathology biopsy report

7.45

2.58

1.4

1.0

—

(3032080) INR in Blood by Coagulation assay

275

1.92

2.50

6.4

7.4

1.09

1.24

inr

—

(3037467) Urinalysis macro (dipstick) panel - Urine

502

1.96

2.49

5.3

3.7

—

(3001604) Monocytes [#/volume] in Blood

367

1.89

2.45

6.3

5.0

0.59

0.55

e9/l

0.50

314

(3006315) Basophils [#/volume] in Blood

369

1.87

2.39

6.4

5.0

0.05

0.04

e9/l

0.91

315

(3034770) Mitochondria Ab [Titer] in Serum

3.69

2.32

1.4

1.0

—

(3019198) Lymphocytes [#/volume] in Blood

372

1.85

2.30

6.3

5.0

1.81

1.82

e9/l

0.02

329

(3049717) Cytology report of Urine Cyto stain

4.10

2.30

2.0

1.6

—

(3044640) Blood type and Crossmatch panel - Blood

197

1.93

2.25

3.3

1.9

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

3.88

2.19

1.4

1.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.23

2.17

1.7

1.5

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

259

1.84

2.16

6.0

2.7

—

(3015736) pH of Urine

277

1.83

2.15

4.8

3.3

—

(3009261) Glucose [Presence] in Urine by Test strip

369

1.80

2.13

5.2

3.4

0.00

estimate

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

5.20

2.09

1.0

1.3

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.63

2.01

2.5

2.4

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

300

1.77

2.00

2.3

1.8

89.39

97.13

pmol/l

0.54

136

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.90

1.99

1.1

1.4

—

(3013115) Eosinophils [#/volume] in Blood

386

1.74

1.93

6.7

5.1

0.24

0.20

e9/l

0.63

332

(3000850) Epithelial cells [#/volume] in Urine

150

1.89

1.87

5.6

1.9

11.39

6.12

e6/l

0.35

130

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.60

1.82

1.6

1.4

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

2.30

1.81

1.1

1.3

—

(3021589) Normoblasts [#/volume] in Blood

335

1.70

1.79

11.3

8.0

0.00

e9/l

0.00

262

(3030467) Casts [#/volume] in Urine by Automated count

202

1.78

6.7

2.6

0.40

0.48

e6/l

0.09

146

(3023368) Bacteria identified in Blood by Culture

177

1.81

1.78

4.8

3.6

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

3.48

1.77

1.3

1.1

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.48

1.77

1.3

2.2

—

(3022145) Colonoscopy Study observation

2.20

1.75

1.6

1.2

—

(3021601) Nitrite [Presence] in Urine by Test strip

365

1.68

1.75

8.2

4.7

0.00

estimate

—

(36304419) Bacteria [Presence] in Urine

196

1.76

1.70

6.7

2.5

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

302

1.68

1.70

2.9

2.3

70.74

77.01

nmol/l

0.95

262

(40760892) CBC W Ordered Manual Differential panel - Blood

164

1.80

1.65

6.1

4.0

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

3.70

1.63

1.6

1.1

—

(3003694) ABO and Rh group [Type] in Blood

200

1.72

1.58

1.5

1.3

—

(3000330) Specific gravity of Urine by Test strip

2.57

1.52

4.2

2.8

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

787

2.16

1.51

18.5

10.7

26.16

21.98

mg/l

0.43

573

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

2.26

1.51

4.1

1.7

54.40

53.93

ml/min/173m2

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

120

1.84

1.48

4.3

2.6

4.12

1.05

e6/l

0.41

(3048929) Epstein Barr virus Ab [Presence] in Serum

3.23

1.45

1.6

1.1

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

3.23

1.45

2.4

2.8

237.00

214.06

—

(3002582) Erythrocytes [#/volume] in Urine

223

1.65

1.42

6.8

2.7

38.96

47.89

e6/l

0.11

170

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.52

1.42

7.1

6.8

—

(3041096) Erythrocytes [Presence] in Urine by Automated

206

1.66

1.41

5.5

3.1

—

(3026782) Osmolality of Urine

133

1.74

1.31

4.5

2.4

594.00

544.70

mosm/kgh2o

0.32

107

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

134

1.72

1.28

1.2

1.4

1.12

11.95

u/ml

1.71

(3018095) Leukocytes [#/volume] in Urine

257

1.56

1.24

7.9

3.4

63.82

77.48

e6/l

0.10

180

(3020564) Creatinine [Moles/volume] in Serum or Plasma

833

1.98

1.15

23.0

12.6

81.49

78.06

umol/l

0.36

833

(3009542) Hematocrit [Volume Fraction] of Blood

723

1.69

1.15

20.7

12.0

38.68

40.48

0.85

511

(3020630) Protein [Mass/volume] in Serum or Plasma

1.97

1.12

1.4

1.3

68.37

67.97

g/l

0.09

(3019550) Sodium [Moles/volume] in Serum or Plasma

806

1.90

1.10

22.2

13.0

139.56

139.77

mmol/l

0.26

777

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.10

1.08

1.3

1.4

—

(3048689) Calprotectin [Mass/mass] in Stool

1.74

1.08

2.4

1.8

136.05

81.94

ug/g

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

116

1.68

1.06

1.4

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

150

1.60

1.05

2.3

2.4

0.62

0.80

ug/l

1.00

(3023103) Potassium [Moles/volume] in Serum or Plasma

809

1.86

1.04

21.1

13.0

3.97

3.98

mmol/l

0.01

779

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

286

1.47

1.01

5.3

3.5

—

(40758558) Short blood count panel - Blood

169

1.56

1.00

5.3

4.9

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.02

0.99

33.0

8.0

0.67

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.02

0.99

33.0

8.1

1.24

1.84

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

214

1.50

0.98

3.3

1.9

2.33

2.35

mmol/l

0.30

186

(3004588) Protein electrophoresis panel - Serum or Plasma

1.84

0.97

1.1

1.3

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

173

1.51

0.90

1.2

1.3

0.37

1.20

u/ml

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.06

0.88

1.5

1.7

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.67

0.87

1.3

1.7

—

(3025941) Bacteria identified in Stool by Culture

1.85

0.86

1.6

1.2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.71

0.82

1.5

1.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.71

0.82

1.5

1.6

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

116

1.56

0.81

4.7

2.8

0.24

3.48

e6/l

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

142

1.51

0.80

1.2

1.3

13.00

35.16

iu/ml

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

151

1.50

0.80

3.2

2894.81

275.19

ng/l

0.42

115

(42870588) Differential panel, method unspecified - Blood

232

1.42

0.79

6.9

4.8

—

(3000991) Gas panel - Venous blood

1.77

0.78

15.0

6.7

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

2.14

0.75

1.4

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

2.14

0.75

1.0

1.3

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

2.14

0.75

1.0

1.3

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.14

0.75

1.0

1.3

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

1.81

0.73

1.4

1.2

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

1.71

0.71

6.2

5.1

1.61

1.39

mmol/l

—

(3008898) HLA-B27 [Presence]

1.83

0.67

1.0

1.1

—

(3026008) Bacteria identified in Urine by Culture

202

1.39

0.67

2.4

2.9

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

148

1.44

0.66

1.8

1.9

471.53

446.49

pmol/l

0.17

118

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.61

0.0

1.4

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.61

0.0

1.4

—

33.86

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

272

1.32

0.58

4.1

3.8

2.14

2.02

ug/l

0.09

243

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.58

0.57

1.6

1.3

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.66

0.56

1.5

1.1

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.66

0.56

2.5

2.9

25.53

25.12

mmol/l

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.66

0.56

3.3

3.8

35.83

52.72

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

217

1.34

0.56

3.0

3.6

22.84

24.94

0.40

107

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.49

0.56

7.2

6.2

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

164

1.36

0.52

4.3

3.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.42

0.52

3.1

2.9

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

103

1.42

0.48

1.4

1.6

—

(3021960) Folate [Moles/volume] in Serum or Plasma

167

1.33

0.47

1.9

1.5

17.25

23.02

nmol/l

1.57

139

(3016701) Glucose [Moles/volume] in Serum or Plasma --2 hours post dose glucose

0.00

0.41

0.0

1.3

—

7.62

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.41

0.0

1.7

—

(3019225) pH of Specimen

1.34

0.40

3.0

3.3

—

(3020682) Albumin/Creatinine [Ratio] in Urine

257

1.24

0.38

4.9

3.9

7.22

9.16

mg/mmol

0.14

159

(3012544) pH of Venous blood

1.33

0.38

9.3

3.3

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.49

0.37

1.5

1.3

—

(3013512) EKG study

222

1.23

0.34

4.3

3.5

—

(3044889) 12 lead EKG panel

558

1.19

0.32

4.4

3.7

—

(1761868) Lipid panel - Serum or Plasma

291

1.20

0.32

3.8

3.0

—

(3012516) Albumin [Mass/volume] in Urine

245

1.20

0.29

4.0

3.2

2560.89

66.67

mg/l

0.48

153

(40761511) CBC panel - Blood by Automated count

831

1.28

0.28

19.2

10.2

—

(3000492) Spirometry study

1.23

0.27

1.4

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.68

0.27

1.2

1.8

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

0.71

0.25

1.8

2.1

1.63

6.14

ug/l

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.74

0.23

1.0

1.6

—

(3035941) MCH [Entitic mass]

879

1.29

0.22

30.2

16.1

30.11

30.35

0.59

859

(3000963) Hemoglobin [Mass/volume] in Blood

879

1.29

0.22

30.5

16.3

131.96

137.49

g/l

2.31

858

(3024731) MCV [Entitic volume]

878

1.31

0.22

30.2

16.2

90.39

90.97

0.57

858

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.20

0.22

1.0

1.4

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.4

—

(3040151) Glucose [Moles/volume] in Capillary blood

0.00

0.21

0.0

4.8

—

7.03

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.21

0.0

1.2

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.21

0.0

1.2

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.21

0.0

1.2

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.1

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.2

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.2

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.2

—

(3041423) Sjogrens syndrome-A extractable nuclear 60kD Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.21

0.0

1.3

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.29

0.21

1.2

200.13

282.20

u/ml

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.21

0.0

1.2

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.20

0.0

1.1

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.19

0.20

1.0

1.1

—

(4010399)

1.16

0.19

1.3

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

313

1.13

0.18

3.7

3.3

35.89

46.43

ng/l

0.21

210

(40761535) Cells panel - Urine sediment

1.16

0.18

2.0

2.7

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

736

1.15

0.17

19.6

10.3

81.27

80.51

ml/min/173m2

0.11

573

(3042936) Bacteria identified in Isolate by Culture

103

1.19

0.14

2.8

1.9

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.82

0.08

1.2

1.7

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.82

0.08

1.3

1.8

—

(3029937) Albumin [Presence] in Urine by Test strip

197

1.08

0.07

5.2

3.6

0.00

estimate

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

483

0.95

0.05

2.8

3.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

122

1.08

0.03

1.5

1.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

122

1.08

0.03

1.9

1.7

—

(3000494) Fungus identified in Specimen by Culture

1.06

0.00

1.0

1.4

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.1

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

2.3

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.98

0.00

1.8

1.6

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

3.0

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

1.8

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.0

1.0

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.6

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

2.4

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum

0.00

0.0

2.8

—

15.62

—

(3002619) Bacteria identified in Specimen by Culture

0.00

0.0

1.0

—

(4027681)

0.00

0.0

1.2

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.6

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

0.0

2.8

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.0

—

(3024263) Appearance of Synovial fluid

0.00

0.0

1.2

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.2

—

6.27

—

(4281824)

0.00

0.0

1.0

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

3.0

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

0.0

1.0

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

1.7

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.0

—

(36660697) Celiac disease serology panel - Serum

0.97

0.00

1.0

1.2

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.00

0.00

1.2

1.6

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.6

—

(40761536) Microorganisms panel - Urine sediment

1.00

0.00

10.3

3.0

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.6

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

0.00

0.0

2.4

—

18.74

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

2.6

—

5.84

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.1

—

11.34

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

68.86

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_EXTRAHEPATIC_BILE_EXALLC – Benign neoplasm: Extrahepatic bile ducts

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Benign neoplasm: Extrahepatic bile ducts

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints