≡ Risteys
FG R12 + FR

Documentation Changelog GitHub Contact & Feedback

Benign neoplasm: Liver/bile ducts

DOID EFO Endpoint Browser PheWeb

CD2_BENIGN_LIVE_BILE

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

882

6. Filter based on genotype QC (FinnGen only)

882

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Similar endpoints

↥

List of similar endpoints to Benign neoplasm: Liver/bile ducts based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4652 3169 1446
Only index persons 4204 2945 1259
Unadjusted period prevalence (%)
Whole population 0.07 0.09 0.04
Only index persons 0.09 0.11 0.05
Median age at first event (years)
Whole population 53.05 49.88 59.76
Only index persons 51.67 48.81 58.37

-FinnGen-

Key figures

All Female Male
Number of individuals 882 627 255
Unadjusted period prevalence (%) 0.18 0.21 0.11
Median age at first event (years) 53.11 49.51 61.98

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
765
Matched controls
7651
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D13.4
ICD-10 Finland
Benign neoplasm: Liver
+∞
323.0
666
*
D37.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Liver, gallbladder and bile ducts
65.9
151.7
174
34
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
27.1
105.7
148
67
D13.5
ICD-10 Finland
Benign neoplasm: Extrahepatic bile ducts
+∞
90.4
85
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
20.4
65.8
100
56
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
6.0
53.3
161
324
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
16.6
49.8
81
54
R93.2
ICD-10 Finland
Abnormal findings on diagnostic imaging of liver and biliary tract
30.9
31.0
41
14
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.5
30.0
355
1983
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
6.5
24.8
66
109
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.7
23.2
184
801
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
21.7
263
1425
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
8.2
20.1
45
58
K76.89
ICD-10 Finland
Other specified diseases of liver
107.9
19.7
21
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.0
18.5
114
419
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.7
17.8
134
559
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
13.0
17.2
30
24
UJF32
NOMESCO Finland
Coloscopy
2.1
16.3
218
1206
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
2.6
15.3
120
509
JN1CD
NOMESCO Finland
Very extensive CT examination of upper part of abdomen
16.9
14.8
23
14
JN3KE
NOMESCO Finland
Abdominal ultrasound with added contrast
18.8
14.8
22
12
D18.0
ICD-10 Finland
Haemangioma, any site
5.7
14.1
40
73
A02BC02
ATC
pantoprazole; systemic
1.8
13.9
489
3777
J01MA02
ATC
ciprofloxacin; systemic
1.8
11.9
290
1956
K76.80
ICD-10 Finland
Hepatic cyst
14.9
11.8
19
13
8170/3-C22.0
ICD-O-3
Hepatocellular carcinoma, NOS, of liver
30.5
11.7
15
5
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.9
11.5
195
1162
21150
ICD-8 Finland
Benign neoplasm of other parts of digestive system, Hepatis
+∞
11.5
11
*
JJB71
NOMESCO Finland
Laparoscopic resection of liver
121.8
11.5
12
*
JJ3AT
NOMESCO Finland
Cytology of liver with ultrasound guidance
44.0
10.9
13
*
JJ1CE
NOMESCO Finland
Liver, bile duct and pancreas endoscopic ultrasound examination
28.5
10.8
14
5
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.3
10.7
107
512
JN3CG
NOMESCO Finland
Extensive MRI examination of abdomen with high intensity magnet
21.8
10.7
15
7
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
12.3
10.4
18
15
JJA21
NOMESCO Finland
Laparoscopic biopsy of liver
40.6
10.0
12
*
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.2
9.8
105
520
JN3DG
NOMESCO Finland
Very extensive MRI examination with high intensity magnet
17.8
9.4
14
8
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
9.4
151
878
JN1BD
NOMESCO Finland
Extensive CT examination of upper part of abdomen
13.9
9.2
15
11
N02AX02
ATC
tramadol; systemic, rectal
1.6
9.1
306
2225
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
8.9
203
1320
D13.9
ICD-10 Finland
Benign neoplasm: Ill-defined sites within the digestive system
50.6
8.7
10
*
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
8.6
163
999
A02BC03
ATC
lansoprazole; oral
1.7
8.4
216
1450
130
Kela drug reimbursment
Malignant tumour
2.5
8.2
62
256
A06AC01
ATC
ispaghula (psylla seeds); oral
1.7
8.2
180
1152
A02BC05
ATC
esomeprazole; systemic
1.6
8.1
299
2203
UJK02
NOMESCO Finland
ERCP
4.5
8.0
27
62
N02BE01
ATC
paracetamol; systemic, rectal
1.7
7.9
640
5713
D41.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Kidney
4.7
7.7
25
55
K76.9
ICD-10 Finland
Liver disease, unspecified
6.0
7.7
20
34
K30
ICD-10 Finland
Functional dyspepsia
2.1
7.7
86
433
R51.80
ICD-10 Finland
Headache
1.9
7.6
120
686
D13.2
ICD-10 Finland
Benign neoplasm: Duodenum
25.3
7.6
10
*
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
9.5
7.3
14
15
XJA00
NOMESCO Finland
Intraoperative abdominal ultrasonography
+∞
7.3
7
*
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
6.1
7.1
18
30
C22.9
ICD-10 Finland
Malignant neoplasm: Liver, unspecified
12.2
7.1
12
10
JN4CD
NOMESCO Finland
Very extensive body CT
3.2
7.0
34
108
P01AB01
ATC
metronidazole; oral, rectal
1.5
7.0
301
2283
R06.0
ICD-10 Finland
Dyspnoea
1.7
6.9
170
1120
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
3.8
6.8
27
73
A02BC01
ATC
omeprazole; systemic
1.6
6.8
201
1392
JJB30
NOMESCO Finland
Excision of two segments of liver
40.4
6.8
8
*
K83.9
ICD-10 Finland
Disease of biliary tract, unspecified
16.9
6.8
10
6
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
6.7
126
767
WX402
NOMESCO Finland
General anaesthesia
1.8
6.7
124
750
C22.1
ICD-10 Finland
Malignant neoplasm: Intrahepatic bile duct carcinoma
22.7
6.7
9
*
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
3.0
6.7
38
133
K83.0
ICD-10 Finland
Cholangitis
6.0
6.6
17
29
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
3.7
6.6
27
75
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
4.9
6.6
20
42
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.1
6.6
76
387
WX302
NOMESCO Finland
Thoracal epidural anesthesy
2.6
6.5
45
179
K83.1
ICD-10 Finland
Obstruction of bile duct
6.6
6.4
15
23
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.3
6.4
56
252
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.8
6.3
113
677
B01AB05
ATC
enoxaparin; parenteral
1.6
6.3
208
1476
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.5
6.3
45
184
JJA20
NOMESCO Finland
Open biopsy of liver
18.2
6.3
9
5
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.9
6.2
91
509
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.2
6.1
62
297
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
2.4
6.1
52
230

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
152
83
21.92
195.63
1.8
2.1
3.5
52.8
u/ml
0.51
152
77
281
646
5.92
122.14
2.5
4.0
2.6
25.5
ug/l
1.15
195
523
168
233
8.67
118.84
2.1
3.2
21.4
1251.0
u/ml
0.98
147
200
650
3669
3.93
73.70
6.9
5.7
10.5
10.6
umol/l
0.15
625
3477
249
777
4.07
70.35
4.0
2.3
5.2
7.0
umol/l
2.11
221
672
66
53
13.38
68.18
1.3
1.2
—
—
—
0
0
90
125
7.90
62.48
2.1
3.8
134.5
2357.1
u/ml
0.60
83
118
206
640
3.89
57.57
2.4
2.1
0.2
0.2
g/l
1.49
199
603
514
2863
2.91
52.18
5.8
4.4
36.0
36.1
g/l
0.15
487
2672
465
2558
2.73
46.69
7.0
7.7
1.1
1.2
inr
0.16
99
791
766
5514
3.96
46.17
9.5
7.0
80.5
76.5
u/l
1.91
737
5187
344
1746
2.59
38.98
5.9
3.4
96.6
93.9
%
1.15
336
1685
402
2247
2.45
36.43
3.2
2.4
57.3
55.9
u/l
0.24
371
2083
80
185
4.66
32.48
1.3
1.1
52.2
88.6
titre
—
9
14
78
195
4.29
28.64
1.3
1.2
—
846.7
—
0
6
569
4029
2.16
25.73
6.4
4.4
6.6
6.5
mmol/l
0.18
546
3732
498
3419
2.05
23.61
4.0
3.9
—
—
—
0
0
296
1696
2.12
22.83
2.4
2.1
—
—
—
0
0
123
503
2.68
20.38
8.7
7.1
8.2
8.9
mmol/l
0.46
117
479
141
623
2.50
19.91
3.4
2.3
31.2
35.9
u/l
0.69
117
530
354
2261
1.94
19.50
2.6
2.1
—
—
—
0
0
188
961
2.22
18.95
3.1
2.2
2.5
2.4
g/l
0.80
176
889
177
883
2.26
18.93
3.2
2.2
23.8
23.1
%
0.28
163
757
199
1047
2.16
18.63
3.1
2.2
13.9
13.6
umol/l
0.32
189
965
559
4201
1.90
18.19
8.7
8.8
4.5
4.0
e9/l
3.91
486
3707
19
17
11.40
18.04
1.3
4.2
—
—
—
0
0
669
5367
2.02
17.57
4.3
3.9
11.8
11.1
mm/h
0.64
628
4994
467
3345
1.84
17.38
8.9
6.1
1.2
1.2
mmol/l
0.09
417
2810
830
7346
3.20
16.22
17.0
12.4
24.0
21.6
mg/l
1.13
715
5754
500
3728
1.79
15.62
6.1
5.6
2.4
1.9
e9/l
0.55
435
3337
423
3007
1.78
15.53
8.3
5.5
1.2
1.2
mmol/l
0.04
391
2729
487
3619
1.77
15.24
6.1
5.6
0.6
0.6
e9/l
0.56
415
3177
501
3760
1.77
15.08
6.3
5.9
0.2
0.2
e9/l
0.04
430
3347
488
3635
1.77
15.08
6.1
5.6
0.0
0.0
e9/l
0.71
417
3192
829
7415
2.96
14.25
18.9
13.8
139.6
139.6
mmol/l
0.04
820
7217
829
7431
2.92
13.88
18.9
13.9
3.9
4.0
mmol/l
1.54
819
7220
147
767
2.10
13.75
11.1
6.7
105.2
104.3
mmol/l
2.24
147
752
153
819
2.05
13.34
6.8
5.1
1.0
1.0
mmol/l
0.43
140
755
244
1531
1.82
13.20
1.5
1.4
2.1
2.3
g/l
1.01
168
951
106
493
2.31
13.16
4.1
3.6
84.2
80.9
ng/l
0.15
88
445
591
4768
1.73
12.66
5.0
4.2
410.6
1764.0
e6/l
—
7
66
175
1007
1.92
12.34
1.3
1.2
—
—
—
0
0
334
2341
1.69
12.02
6.3
5.7
—
—
—
0
0
459
3507
1.64
11.71
6.4
5.7
28.3
28.5
%
0.14
433
3288
177
1040
1.88
11.66
1.5
1.3
591.0
525.9
titre
0.17
40
230
114
575
2.13
11.57
1.4
1.4
—
—
—
0
0
611
5031
1.70
11.55
4.7
4.1
—
—
—
0
0
167
966
1.90
11.54
2.1
2.3
125.7
111.5
ug/g
0.24
126
763
454
3473
1.63
11.42
6.3
5.5
58.1
57.0
%
1.39
429
3265
265
1766
1.72
11.38
1.3
1.2
0.6
1.6
u/ml
2.43
78
494
270
1815
1.70
11.21
3.6
2.8
—
—
—
0
0
446
3410
1.62
11.14
6.6
5.9
8.0
8.3
%
2.41
421
3210
444
3393
1.62
11.10
6.4
5.6
2.7
2.8
%
0.64
419
3172
340
2435
1.64
11.03
4.7
3.5
39.8
92.8
e6/l
1.74
231
1661
431
3273
1.62
11.03
6.4
5.7
0.6
0.7
%
0.36
405
3063
157
916
1.87
10.50
1.5
1.6
—
—
—
0
0
65
269
2.53
10.42
2.8
1.9
23.2
21.2
s
0.48
57
238
401
3025
1.60
10.33
2.6
2.0
—
—
—
0
0
289
2014
1.65
10.29
4.1
3.0
53.0
101.4
e6/l
0.58
210
1535
170
1025
1.82
10.21
3.5
2.8
2.8
3.0
e6/l
0.09
90
543
269
1846
1.66
10.15
3.8
2.9
0.3
0.4
e6/l
0.37
186
1368
140
796
1.90
10.12
1.4
1.3
—
—
—
0
0
250
1693
1.67
9.89
4.1
4.0
—
—
—
0
0
254
1739
1.65
9.59
2.5
2.0
2.8
2.9
mg/l
0.41
216
1489
248
1688
1.65
9.58
2.1
1.7
1.0
1.0
mg/l
0.05
195
1271
124
693
1.92
9.42
10.0
7.7
0.4
1.2
mmol/l
1.54
105
548
153
915
1.81
9.39
1.3
1.3
—
—
—
0
0
71
323
2.30
9.26
7.9
10.1
—
—
—
0
0
187
1220
1.68
8.38
3.4
3.4
1806.7
300.0
ng/l
0.62
128
865
252
1788
1.57
7.98
2.9
2.4
1325.8
5631.8
umol/l
2.45
223
1546
87
464
1.97
7.56
12.7
8.8
—
—
—
0
0
330
2529
1.49
7.15
3.3
3.3
27.8
31.4
ng/l
0.23
199
1588
164
1079
1.64
7.02
4.0
3.1
0.8
0.8
mmol/l
0.13
149
1010
833
7814
2.19
6.85
13.7
9.6
29.3
25.5
u/l
6.38
816
7561
306
2327
1.48
6.82
3.0
3.3
2.4
2.3
mmol/l
0.89
266
2053
349
2736
1.46
6.61
2.1
1.9
99.5
96.5
pmol/l
0.53
200
1442
424
3452
1.44
6.54
3.9
2.7
115.7
102.6
ug/l
0.68
403
3222
28
96
2.98
6.47
1.0
1.0
0.1
0.1
u/ml
—
9
21
149
977
1.63
6.44
2.2
1.9
—
—
—
0
0
29
102
2.91
6.42
1.0
1.1
5.6
6.8
u/ml
0.12
13
35
224
1620
1.51
6.31
3.7
3.4
—
—
—
0
0
120
749
1.70
6.26
26.1
20.2
1.3
1.2
inr
0.08
12
104
244
1801
1.49
6.21
7.3
6.2
—
—
—
0
0
98
581
1.77
6.13
1.4
1.2
—
—
—
0
0
35
140
2.56
6.09
1.0
1.1
1.5
5.4
u/ml
1.50
19
66
47
216
2.24
6.05
1.5
1.4
303.6
295.1
ug/g
0.09
25
124
37
153
2.48
6.02
1.1
1.1
0.7
1.5
u/ml
0.76
13
56
264
1990
1.47
6.02
5.6
3.8
7.4
7.4
ph
0.63
36
382
85
486
1.83
6.00
1.6
1.4
—
—
—
0
0
436
3610
1.41
5.90
4.1
3.4
0.0
0.0
estimate
0.00
61
696
441
3661
1.41
5.87
4.0
3.4
0.0
0.0
estimate
0.50
62
681
436
3613
1.41
5.86
5.6
4.6
0.0
0.0
estimate
0.50
65
700
63
333
1.96
5.65
2.7
2.3
—
—
—
0
0
33
135
2.50
5.51
1.0
1.1
0.3
0.9
u/ml
1.59
12
54
821
7746
1.87
5.33
16.2
11.8
—
—
—
0
0
183
1317
1.49
5.18
3.9
2.6
542.8
550.8
mosm/kgh2o
0.18
150
1129
13
31
4.24
5.10
2.2
2.1
2.2
8.6
nmol/l
—
8
22
84
503
1.74
5.09
1.2
1.2
—
—
—
0
0
168
1195
1.50
5.03
2.9
2.7
2.5
2.4
mmol/l
1.46
151
1057
652
5867
1.43
5.02
4.7
4.1
14.6
14.6
pmol/l
0.09
604
5396
268
2087
1.41
4.96
2.7
2.8
—
—
—
0
0
56
298
1.94
4.95
1.6
1.6
—
—
—
0
0
31
130
2.44
4.94
1.0
1.0
0.4
2.2
u/ml
1.12
12
29
562
4938
1.38
4.93
3.8
3.5
—
—
—
0
0
192
1411
1.46
4.87
3.2
2.4
5.3
7.0
e6/l
0.83
160
1237
28
113
2.53
4.83
1.0
1.0
1.4
3.2
u/ml
0.92
14
36
120
803
1.57
4.74
1.8
1.6
—
—
—
0
0
84
515
1.70
4.69
1.2
1.3
115.5
206.0
u/ml
1.06
77
476
32
140
2.33
4.66
1.2
1.3
—
—
—
0
0
742
6885
1.49
4.47
5.7
4.8
1.7
2.0
mu/l
1.02
697
6372
253
1994
1.38
4.27
2.1
2.1
152.8
212.6
u/l
0.73
239
1883
81
508
1.65
4.17
2.0
2.3
7.2
6.3
ug/l
0.14
72
445
36
174
2.11
4.17
2.5
4.0
38.3
33.2
mg/l
0.18
31
140
28
124
2.30
4.00
3.4
2.1
—
—
—
0
0
221
1722
1.38
3.96
2.7
3.0
1438.3
1072.7
ng/l
0.52
189
1444
35
174
2.05
3.79
2.6
4.0
45.0
88.4
mg/l
0.60
30
140
26
115
2.30
3.74
1.3
1.2
—
—
—
0
0
100
679
1.53
3.71
2.1
2.5
1.9
1.8
%
0.16
89
600
251
2014
1.34
3.70
3.7
3.1
7.9
7.6
mmol/l
0.53
223
1699
43
235
1.87
3.58
10.3
4.7
—
—
—
0
0
21
87
2.45
3.49
2.8
2.2
—
—
—
0
0
173
1321
1.39
3.48
1.7
1.6
—
—
—
0
0
178
1372
1.37
3.38
1.3
1.3
26.9
32.1
iu/ml
0.25
48
436
28
134
2.13
3.37
1.5
1.2
1.9
5.9
u/ml
1.10
13
47
154
1163
1.39
3.30
1.7
1.7
1079.6
1213.0
nmol/l
1.13
121
882
36
191
1.92
3.29
10.9
4.0
3.8
3.8
mmol/l
0.33
36
177
45
257
1.79
3.28
1.9
2.2
1.5
1.5
g/l
0.09
38
222
240
1944
1.32
3.27
4.6
4.0
15.1
8.9
mg/mmol
0.65
171
1213
13
43
3.05
3.26
1.2
1.0
—
—
—
0
0
372
3196
1.28
3.25
9.6
8.7
0.0
0.0
e9/l
0.22
293
2641
77
509
1.56
3.24
2.1
2.6
4.4
4.1
e9/l
0.45
53
411
77
509
1.56
3.24
3.2
3.4
4.5
4.6
pmol/l
0.25
69
448
82
550
1.54
3.24
4.9
3.5
—
—
—
0
0
24
110
2.21
3.21
1.2
1.0
—
—
—
0
0
170
1314
1.36
3.16
1.3
1.3
16.7
12.1
u/ml
0.27
77
516
64
408
1.61
3.14
1.1
1.1
—
167.3
—
0
7
118
860
1.43
3.10
1.3
1.4
—
—
—
0
0
67
434
1.59
3.08
1.3
1.2
—
—
—
0
0
99
700
1.47
3.05
2.0
2.0
397.5
376.0
nmol/l
0.41
84
651
48
286
1.72
3.04
1.3
1.4
—
4.4
—
0
6
40
226
1.81
3.03
10.1
4.1
1.1
1.3
mmol/l
1.26
40
220
13
45
2.92
3.03
5.8
7.3
—
—
—
0
0
671
6238
1.32
3.03
21.4
15.2
13.7
13.6
%
0.53
665
6120
62
396
1.61
3.03
7.5
5.1
—
—
—
0
0
228
1855
1.31
2.98
3.8
3.3
811.7
405.2
mg/l
0.44
159
1173
24
114
2.14
2.96
1.1
1.1
—
—
—
0
0
200
1601
1.32
2.94
1.6
1.5
18.8
20.8
nmol/l
1.40
172
1380
79
539
1.51
2.90
3.6
3.3
—
—
—
0
0
9
22
4.12
2.88
3.4
2.3
—
—
—
0
0
78
532
1.51
2.87
5.1
3.5
2.0
1.9
mmol/l
0.03
65
420
12
41
2.95
2.86
1.2
1.0
—
—
—
0
0
43
254
1.73
2.83
1.7
1.5
1.3
1.2
g/l
0.73
43
241
73
493
1.52
2.82
2.4
2.6
67.0
71.4
e9/l
0.72
57
378
8
18
4.47
2.80
1.0
1.1
—
—
—
0
0
38
635
0.58
2.79
5.4
3.5
—
—
—
0
0
9
23
3.94
2.78
1.1
1.1
—
—
—
0
0
7
14
5.03
2.73
2.9
5.3
—
—
—
0
0
847
8229
1.74
2.68
26.5
18.5
266.3
256.9
e9/l
3.29
829
8040
847
8232
1.73
2.63
26.5
18.4
90.3
90.8
fl
2.17
839
8128
26
134
1.97
2.62
1.0
1.1
—
—
—
0
0
847
8234
1.72
2.60
26.5
18.4
30.0
30.2
pg
3.59
839
8129
42
253
1.69
2.60
1.3
1.2
—
—
—
0
0
847
8235
1.72
2.59
26.6
18.5
4.5
4.5
e12/l
0.16
831
8029
847
8237
1.71
2.56
26.6
18.5
7.1
6.7
e9/l
6.92
831
8023
703
6624
1.30
2.56
6.5
5.2
39.8
39.1
mmol/mol
1.20
665
6189
5
7
7.18
2.55
8.4
3.1
5.8
8.0
mmol/l
—
5
7
847
8240
1.70
2.51
26.7
18.6
134.2
134.9
g/l
0.88
840
8132
736
6985
1.32
2.49
4.3
3.7
1.4
1.3
mmol/l
5.86
687
6465
18
83
2.19
2.42
1.1
1.2
—
—
—
0
0
93
681
1.41
2.41
4.0
3.6
—
—
—
0
0
190
1551
1.29
2.39
4.8
3.7
1.0
1.0
kg/l
0.41
24
212
762
7284
1.34
2.32
4.9
4.1
4.7
4.7
mmol/l
0.70
723
6807
81
583
1.43
2.31
1.4
1.5
—
—
—
0
0
71
501
1.45
2.26
2.1
2.8
66.7
67.3
g/l
0.29
64
455
60
411
1.49
2.21
2.0
2.4
—
—
—
0
0
723
6873
1.29
2.21
20.2
13.3
39.7
39.9
%
0.22
555
5201
32
188
1.73
2.20
3.1
3.0
—
—
—
0
0
227
1914
1.25
2.18
4.1
3.5
—
—
—
0
0
6
14
4.31
2.15
1.8
1.9
—
—
—
0
0
38
237
1.63
2.11
2.2
2.1
4.6
2.8
ug/l
0.20
31
211
56
383
1.49
2.09
3.4
2.1
12.5
12.1
nmol/l
0.10
46
342
16
75
2.15
2.09
4.6
5.0
10.4
57.8
u/ml
—
6
24
37
230
1.64
2.08
3.2
2.6
—
—
—
0
0
757
7253
1.31
2.08
4.8
4.1
1.5
1.5
mmol/l
1.96
711
6747
18
89
2.04
2.07
1.1
1.2
0.5
0.6
nmol/l
0.55
18
84
70
504
1.42
2.02
1.4
1.3
25.5
28.7
iu/l
0.39
59
436
11
44
2.52
2.01
1.1
1.1
1.6
0.2
u/ml
—
5
16
8
26
3.10
2.01
1.3
1.2
—
—
—
0
0
9
32
2.83
2.00
1.0
1.2
—
—
—
0
0
15
70
2.16
1.99
1.4
1.2
—
—
—
0
0
39
250
1.59
1.96
2.6
5.6
1.7
1.6
%
0.30
39
235
8
27
2.98
1.94
43.5
25.5
7.0
7.2
ug/l
—
8
22
24
135
1.80
1.93
2.3
4.5
—
—
—
0
0
13
58
2.26
1.91
2.6
2.4
1.5
1.1
e9/l
—
6
32
247
2134
1.22
1.86
1.4
1.5
—
—
—
0
0
8
28
2.87
1.86
1.8
1.3
—
—
—
0
0
40
262
1.55
1.84
7.2
3.7
24.4
24.1
mmol/l
0.27
35
235
9
35
2.59
1.80
1.4
2.4
4305.0
653.4
u/ml
—
9
35
6
18
3.35
1.75
1.0
1.1
—
—
—
0
0
11
48
2.31
1.71
1.3
1.2
—
—
—
0
0
54
384
1.43
1.70
1.7
2.1
5040.2
3892.8
u/l
0.13
17
159
113
903
1.29
1.69
3.0
2.9
0.8
0.7
ug/l
0.66
80
591
736
7071
1.25
1.66
4.8
4.2
5.9
5.8
mmol/l
1.12
691
6509
6
19
3.17
1.66
1.0
1.0
—
—
—
0
0
24
142
1.71
1.66
1.8
1.4
—
—
—
0
0
765
7388
1.27
1.61
5.4
4.5
2.7
2.8
mmol/l
1.73
721
6868
220
1906
1.21
1.60
1.7
1.6
1.6
1.4
mmol/l
2.27
199
1629
64
477
1.37
1.56
1.3
1.3
—
39.2
—
0
26
16
85
1.90
1.55
1.8
1.4
—
37.2
—
0
5
43
299
1.46
1.54
2.7
3.0
—
—
—
0
0
104
839
1.27
1.47
1.5
1.4
—
—
—
0
0
5
16
3.14
1.44
1.6
1.4
—
—
—
0
0
5
16
3.14
1.44
1.0
1.1
—
—
—
0
0
35
237
1.50
1.44
3.8
3.2
0.2
0.3
g/l
0.31
19
90
199
1726
1.20
1.43
3.3
4.4
—
—
—
0
0
181
1558
1.20
1.41
5.2
4.8
2.7
2.3
ug/l
0.44
170
1388
22
134
1.66
1.40
3.0
7.9
11.5
11.1
mmol/l
0.23
22
122
22
134
1.66
1.40
3.0
7.9
103.1
105.2
mmol/l
1.04
22
122
20
119
1.70
1.38
2.2
1.5
—
—
—
0
0
21
127
1.67
1.37
1.6
1.4
91.3
110.8
u/ml
—
6
28
22
138
1.61
1.27
1.3
1.2
180.5
270.7
u/ml
1.57
11
85
30
203
1.49
1.26
1.4
1.2
1.6
2.9
u/ml
—
5
24
40
289
1.40
1.21
2.8
3.3
25.3
25.3
mmol/l
0.02
40
283
6
26
2.32
1.19
1.8
1.5
—
—
—
0
0
48
364
1.34
1.10
1.0
1.1
—
—
—
0
0
88
723
1.24
1.10
1.5
1.4
—
—
—
0
0
5
21
2.39
1.09
1.6
1.2
—
—
—
0
0
23
154
1.51
1.04
2.6
2.4
68.0
112.8
ug/min
0.38
15
94
9
46
1.97
1.03
2.3
2.2
621.4
554.8
ml
—
9
25
215
1930
1.15
1.01
4.8
3.7
0.0
0.0
estimate
1.08
63
685
7
35
2.01
1.00
1.1
1.3
—
—
—
0
0
31
224
1.40
0.97
1.3
1.2
—
—
—
0
0
33
242
1.38
0.96
1.3
1.4
—
—
—
0
0
14
85
1.66
0.94
1.4
1.3
—
—
—
0
0
28
200
1.41
0.94
1.9
1.7
—
—
—
0
0
7
37
1.90
0.94
2.1
2.2
498.6
497.7
min
—
7
23
52
410
1.29
0.94
3.0
3.0
5.1
5.1
kpa
0.07
44
386
12
70
1.72
0.93
1.1
1.1
—
—
—
0
0
10
55
1.83
0.92
1.1
1.0
—
—
—
0
0
31
227
1.38
0.91
1.2
1.2
—
—
—
0
0
6
28
2.15
0.91
1.7
1.6
—
—
—
0
0
9
156
0.57
0.88
1.2
1.9
—
—
—
0
0
13
79
1.66
0.88
1.4
1.1
—
—
—
0
0
15
95
1.59
0.88
2.7
2.6
—
—
—
0
0
6
30
2.01
0.87
1.0
1.0
—
—
—
0
0
10
57
1.76
0.84
1.2
1.1
—
—
—
0
0
11
66
1.68
0.79
1.0
1.6
—
—
—
0
0
9
55
1.64
0.73
1.6
1.3
6.2
6.3
mmol/l
—
9
50
9
55
1.64
0.73
1.0
1.2
—
—
—
0
0
11
68
1.63
0.72
1.5
1.7
—
—
—
0
0
9
143
0.63
0.70
1.8
3.9
60.1
56.4
%
—
9
143
262
2809
0.90
0.69
2.6
2.7
—
—
—
0
0
38
302
1.27
0.69
1.4
1.4
—
—
—
0
0
10
61
1.65
0.68
1.1
1.5
1.8
1.6
nmol/l
—
10
54
160
1449
1.13
0.68
1.6
1.7
418.7
34258178.9
pmol/l
1.81
136
1226
38
303
1.27
0.67
1.4
1.4
—
—
—
0
0
28
214
1.32
0.67
1.2
1.2
11.6
11.2
u/l
0.04
18
171
13
86
1.52
0.66
1.8
1.3
—
—
—
0
0
5
28
1.79
0.66
1.4
1.1
—
—
—
0
0
38
305
1.26
0.64
1.4
1.4
—
—
—
0
0
9
138
0.65
0.61
1.8
3.5
4.9
4.2
e9/l
—
9
138
8
51
1.57
0.60
1.5
2.1
—
0.9
—
0
5
0
21
0.00
0.60
0.0
1.1
—
37.8
—
0
13
18
131
1.38
0.59
1.3
1.1
—
11.6
—
0
13
11
72
1.53
0.59
1.4
1.1
—
—
—
0
0
221
2057
1.10
0.58
3.9
3.0
—
—
—
0
0
15
106
1.42
0.58
1.7
1.4
—
—
—
0
0
37
301
1.24
0.57
1.4
1.4
—
—
—
0
0
35
283
1.25
0.57
1.4
1.4
—
—
—
0
0
6
36
1.67
0.56
2.7
2.6
—
—
—
0
0
9
61
1.48
0.54
2.1
1.5
—
—
—
0
0
11
74
1.49
0.53
4.7
2.0
—
—
—
0
0
9
62
1.46
0.53
2.3
2.6
—
—
—
0
0
9
62
1.46
0.53
1.0
1.0
180.2
230.2
mg/l
—
9
51
10
66
1.52
0.52
2.9
3.3
—
—
—
0
0
36
296
1.23
0.52
1.4
1.2
—
—
—
0
0
12
83
1.45
0.52
1.6
1.6
—
—
—
0
0
12
83
1.45
0.52
1.6
1.6
—
—
—
0
0
12
83
1.45
0.52
1.6
1.6
—
—
—
0
0
12
83
1.45
0.52
1.6
1.6
—
—
—
0
0
9
65
1.39
0.50
1.2
1.1
33.4
34.0
mg/l
—
9
51
17
127
1.35
0.50
1.6
1.6
—
—
—
0
0
26
208
1.26
0.48
1.2
1.1
—
—
—
0
0
38
318
1.20
0.48
1.1
1.1
—
—
—
0
0
39
462
0.84
0.48
2.2
2.5
—
—
—
0
0
14
102
1.38
0.47
1.2
1.2
—
—
—
0
0
12
85
1.42
0.47
1.2
1.1
—
—
—
0
0
13
96
1.36
0.41
1.6
1.5
—
—
—
0
0
78
865
0.89
0.41
1.4
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
2.2
—
0
16
5
34
1.47
0.40
2.0
1.4
140.6
149.6
nmol/l
—
5
34
18
225
0.80
0.38
1.3
1.4
—
—
—
0
0
67
601
1.12
0.38
1.2
1.2
148.2
154.8
iu/ml
0.04
24
247
8
111
0.72
0.37
3.8
2.3
—
—
—
0
0
18
224
0.80
0.37
1.3
1.4
—
—
—
0
0
20
162
1.24
0.35
1.4
1.4
23.9
27.4
u/l
0.19
15
135
6
43
1.40
0.35
2.5
1.3
—
—
—
0
0
19
232
0.81
0.34
1.4
1.5
—
—
—
0
0
60
540
1.12
0.33
3.9
4.3
0.1
0.1
%
0.18
12
154
61
550
1.12
0.33
5.0
3.4
1.2
1.2
mmol/l
0.29
55
477
10
74
1.36
0.32
1.2
1.1
—
—
—
0
0
170
1609
1.07
0.32
1.9
1.8
—
—
—
0
0
10
132
0.75
0.32
4.0
2.5
—
—
—
0
0
12
92
1.31
0.32
1.6
1.7
—
—
—
0
0
14
110
1.28
0.32
1.1
1.1
—
72.8
—
0
25
7
55
1.27
0.30
3.4
2.6
—
—
—
0
0
7
56
1.25
0.29
1.0
1.1
—
—
—
0
0
7
57
1.23
0.29
1.3
1.3
—
62.3
—
0
8
18
149
1.21
0.28
1.1
1.4
0.3
0.3
nmol/l
0.56
13
118
8
67
1.20
0.26
1.9
1.2
—
—
—
0
0
15
123
1.22
0.25
1.2
1.6
—
—
—
0
0
9
73
1.24
0.25
1.0
1.1
—
—
—
0
0
25
217
1.16
0.24
1.5
1.9
1.8
4.9
iu/l
—
6
82
5
40
1.25
0.22
1.4
1.4
5.1
6.2
mmol/l
—
5
40
5
42
1.19
0.21
1.2
2.0
7.4
9.1
mmol/l
—
5
36
21
241
0.87
0.21
4.7
8.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
3.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
7.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
6.2
—
—
—
0
0
10
80
1.25
0.20
1.1
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
96
911
1.06
0.19
1.9
1.8
—
—
—
0
0
6
53
1.13
0.18
1.3
1.2
—
—
—
0
0
49
528
0.92
0.18
1.4
1.4
—
—
—
0
0
87
913
0.95
0.16
1.6
1.6
—
—
—
0
0
37
341
1.09
0.16
1.3
1.5
275.7
308.7
mu/l
0.39
32
308
14
122
1.15
0.13
1.8
1.8
—
—
—
0
0
14
122
1.15
0.13
1.1
1.4
—
—
—
0
0
55
525
1.05
0.10
3.6
4.2
0.0
0.6
%
—
9
129
14
125
1.12
0.10
4.0
2.7
—
—
—
0
0
60
575
1.05
0.10
3.9
4.2
1.1
1.0
%
0.04
12
172
5
44
1.14
0.10
1.4
1.9
11.0
10.9
%
—
5
44
54
517
1.05
0.09
3.8
4.4
0.0
0.8
%
—
10
132
17
155
1.10
0.09
1.0
1.6
—
—
—
0
0
6
55
1.09
0.09
1.0
1.1
—
—
—
0
0
18
165
1.09
0.08
5.5
4.4
—
—
—
0
0
6
56
1.07
0.08
1.2
1.1
—
—
—
0
0
6
57
1.05
0.08
1.0
1.4
1.2
1.2
promille
—
6
45
6
57
1.05
0.08
2.5
1.3
—
—
—
0
0
7
65
1.08
0.08
4.3
2.8
—
—
—
0
0
7
81
0.86
0.07
3.1
2.5
—
—
—
0
0
7
82
0.85
0.07
3.1
2.5
4.5
4.0
mmol/l
—
7
82
7
82
0.85
0.07
3.1
2.5
107.9
106.0
mmol/l
—
7
82
9
84
1.07
0.07
2.7
2.6
—
—
—
0
0
18
167
1.08
0.07
1.6
1.6
6111.9
14921.7
e6/l
—
10
125
14
128
1.10
0.06
1.6
1.2
—
—
—
0
0
12
109
1.10
0.06
1.2
1.5
—
—
—
0
0
32
306
1.05
0.05
1.1
1.3
221.1
247.9
miu/ml
0.24
16
148
17
178
0.95
0.02
1.2
1.1
—
—
—
0
0
14
133
1.05
0.01
1.5
1.7
—
—
—
0
0
15
157
0.95
0.01
1.0
1.1
—
—
—
0
0
14
146
0.96
0.00
1.1
1.1
—
—
—
0
0
14
146
0.96
0.00
1.1
1.1
—
—
—
0
0
53
524
1.01
0.00
1.8
1.8
—
—
—
0
0
32
316
1.01
0.00
1.8
1.7
—
—
—
0
0
14
138
1.01
0.00
2.5
2.0
129.9
129.8
g/l
—
7
102
33
329
1.00
0.00
4.2
3.1
—
—
—
0
0
20
203
0.98
0.00
1.4
1.3
—
—
—
0
0
5
58
0.86
0.00
2.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
41.0
—
0
7
8
83
0.96
0.00
2.0
2.3
—
—
—
0
0
0
7
0.00
0.00
0.0
6.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
18.3
—
0
8
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
7
76
0.92
0.00
1.9
2.0
32.4
32.3
pg
—
7
76
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_LIVE_BILE and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_LIVE_BILE 1.65 [1.41, 1.93] < 0.001
Birth year 0.994 [0.99, 1.0] 0.164

During the follow-up period (1.1.1998 — 31.12.2019), 315 out of 2402 females with CD2_BENIGN_LIVE_BILE died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_LIVE_BILE 1.985 [1.62, 2.42] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 310 out of 1102 males with CD2_BENIGN_LIVE_BILE died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_LIVE_BILE.

N-year risk Females Males
1 0.15% 0.324%
5 0.89% 2.124%
10 2.35% 5.521%
15 4.438% 10.241%
20 7.635% 16.824%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_LIVE_BILE – Benign neoplasm: Liver/bile ducts

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data