liver neoplasm: A benign or malignant epithelial neoplasm that affects the liver parenchyma and intrahepatic bile ducts. Representative examples of benign epithelial neoplasms include hepatocellular adenoma and intrahepatic bile duct adenoma. Representative examples of malignant epithelial neoplasms include hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
786 |
4. Check minimum number of eventsNone |
786 |
5. Include endpointsNone |
786 |
6. Filter based on genotype QC (FinnGen only) |
786 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D13
- Name in latin
- Neoplasma benignum hepatis
Similar endpoints
↥List of similar endpoints to
Benign neoplasm: Liver
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm: Liver
- Benign neoplasm: Liver/bile ducts
- Benign neoplasm: Liver/bile ducts
- Benign neoplasm of other and ill-defined parts of digestive system
- Benign neoplasm of other and ill-defined parts of digestive system
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3928 | 2744 | 1154 |
| Only index persons | 3579 | 2565 | 1014 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.08 | 0.03 |
| Only index persons | 0.08 | 0.09 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 51.46 | 48.25 | 58.77 |
| Only index persons | 50.04 | 46.94 | 57.87 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 786 | 574 | 212 |
| Unadjusted period prevalence (%) | 0.17 | 0.20 | 0.09 |
| Median age at first event (years) | 52.28 | 48.71 | 61.94 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 677
- Matched controls
- 6768
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D13.4
ICD-10 Finland
Benign neoplasm: Liver
4503599627370496.0
323.0
666
*
D37.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Liver, gallbladder and bile ducts
86.8
145.6
160
24
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
25.6
96.8
138
67
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
15.5
58.6
99
74
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
6.2
50.0
147
288
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
19.3
49.3
76
44
R93.2
ICD-10 Finland
Abnormal findings on diagnostic imaging of liver and biliary tract
38.5
31.9
40
11
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.6
28.9
314
1700
R10.1
ICD-10 Finland
Pain localized to upper abdomen
3.1
26.1
165
633
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
7.5
24.0
58
84
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.5
22.5
228
1148
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.3
19.8
108
366
K76.89
ICD-10 Finland
Other specified diseases of liver
43.2
17.4
21
5
JN3KE
NOMESCO Finland
Abdominal ultrasound with added contrast
28.3
16.6
22
8
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
13.2
16.3
28
22
D18.0
ICD-10 Finland
Haemangioma, any site
7.1
16.0
39
58
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.7
16.0
123
522
UJF32
NOMESCO Finland
Coloscopy
2.2
15.9
193
1031
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
6.4
13.5
35
57
JN1CD
NOMESCO Finland
Very extensive CT examination of upper part of abdomen
12.6
12.7
22
18
JJB71
NOMESCO Finland
Laparoscopic resection of liver
+∞
12.5
12
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.0
12.2
181
1038
A02BC02
ATC
pantoprazole; systemic
1.8
12.1
435
3373
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
16.8
11.7
18
11
8170/3-C22.0
ICD-O-3
Hepatocellular carcinoma, NOS, of liver
30.6
11.7
15
5
21150
ICD-8 Finland
Benign neoplasm of other parts of digestive system, Hepatis
+∞
11.5
11
*
J01MA02
ATC
ciprofloxacin; systemic
1.7
10.1
255
1740
K76.80
ICD-10 Finland
Hepatic cyst
8.8
9.3
19
22
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.2
9.2
92
444
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
8.9
183
1161
A02BC03
ATC
lansoprazole; oral
1.8
8.8
188
1208
N02AX02
ATC
tramadol; systemic, rectal
1.7
8.7
267
1902
JN3CG
NOMESCO Finland
Extensive MRI examination of abdomen with high intensity magnet
16.5
8.6
13
8
JJ3AT
NOMESCO Finland
Cytology of liver with ultrasound guidance
27.9
8.5
11
*
C22.9
ICD-10 Finland
Malignant neoplasm: Liver, unspecified
27.9
8.5
11
*
A02BC05
ATC
esomeprazole; systemic
1.6
8.3
262
1878
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.0
8.3
119
666
K76.9
ICD-10 Finland
Liver disease, unspecified
6.9
8.1
19
28
JN3DG
NOMESCO Finland
Very extensive MRI examination with high intensity magnet
11.9
8.1
14
12
JN1BD
NOMESCO Finland
Extensive CT examination of upper part of abdomen
11.0
7.8
14
13
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.0
7.7
100
534
D41.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Kidney
5.0
7.6
23
47
N02BE01
ATC
paracetamol; systemic, rectal
1.8
7.6
568
5041
130
Kela drug reimbursment
Malignant tumour
2.6
7.6
55
223
A06AC01
ATC
ispaghula (psylla seeds); oral
1.8
7.5
154
969
JN4CD
NOMESCO Finland
Very extensive body CT
3.6
7.5
32
92
P01AB01
ATC
metronidazole; oral, rectal
1.6
7.4
272
2012
R51.80
ICD-10 Finland
Headache
1.9
7.2
107
606
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
5.4
7.1
20
38
WX302
NOMESCO Finland
Thoracal epidural anesthesy
2.8
7.0
42
155
R06.0
ICD-10 Finland
Dyspnoea
1.7
6.9
153
983
B01AB05
ATC
enoxaparin; parenteral
1.6
6.8
188
1288
JJB30
NOMESCO Finland
Excision of two segments of liver
40.4
6.8
8
*
K30
ICD-10 Finland
Functional dyspepsia
2.1
6.7
73
364
A02BC01
ATC
omeprazole; systemic
1.7
6.7
174
1168
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
4.0
6.7
25
64
C22.1
ICD-10 Finland
Malignant neoplasm: Intrahepatic bile duct carcinoma
22.8
6.7
9
*
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
2.9
6.7
38
134
JJA21
NOMESCO Finland
Laparoscopic biopsy of liver
12.4
6.6
11
9
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.0
6.5
86
465
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.0
6.5
82
435
UKC02
NOMESCO Finland
Cystoscopy
2.0
6.5
89
485
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
6.5
142
910
D13.9
ICD-10 Finland
Benign neoplasm: Ill-defined sites within the digestive system
70.5
6.4
7
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
6.2
248
1853
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.2
6.1
57
267
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
6.0
133
852
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
146
74
24.00
194.59
1.8
2.1
3.5
59.4
u/ml
0.51
146
68
154
209
8.92
111.16
2.2
3.2
11.0
1370.9
u/ml
0.98
136
181
251
569
6.01
111.05
2.5
4.0
2.6
14.6
ug/l
0.92
170
458
584
3256
4.09
68.98
6.8
5.7
10.4
10.6
umol/l
0.18
561
3087
84
101
9.19
65.87
1.9
4.1
143.9
453.1
u/ml
0.57
77
96
194
564
4.24
60.29
2.4
2.1
0.2
0.2
g/l
0.61
187
530
220
705
3.94
59.64
3.9
2.4
5.2
6.8
umol/l
1.92
194
613
462
2548
2.97
48.53
5.6
4.3
36.2
36.2
g/l
0.09
438
2385
684
4905
4.04
42.15
9.4
7.0
79.3
76.2
u/l
1.47
659
4619
355
1991
2.43
31.83
3.2
2.4
56.7
56.0
u/l
0.10
327
1850
374
2204
2.33
29.27
4.2
3.1
30.5
29.7
u/l
0.24
361
2105
508
3589
2.17
23.34
6.1
4.4
6.6
6.5
mmol/l
0.20
487
3315
269
1520
2.17
21.85
2.4
2.1
—
—
—
0
0
111
434
2.81
20.19
8.0
7.1
7.7
8.9
mmol/l
0.89
105
416
442
3079
2.00
19.63
4.0
3.8
—
—
—
0
0
168
838
2.28
18.14
2.9
2.2
2.5
2.4
g/l
1.10
157
774
158
770
2.32
18.02
3.1
2.2
23.9
23.0
%
0.31
145
665
583
4549
2.09
17.99
4.4
2.9
60.2
42.9
u/l
5.45
561
4296
176
911
2.20
17.30
3.0
2.2
14.2
13.6
umol/l
0.49
167
836
385
2655
1.88
16.62
7.8
5.5
1.2
1.2
mmol/l
0.06
355
2411
499
3751
1.90
16.32
8.7
8.7
4.4
4.0
e9/l
3.06
432
3311
600
4810
2.05
16.07
4.3
3.9
11.8
10.8
mm/h
0.88
561
4486
414
2952
1.85
15.79
8.6
6.1
1.2
1.2
mmol/l
0.02
371
2475
744
6577
3.46
15.24
16.8
12.3
23.7
21.2
mg/l
1.13
643
5147
120
566
2.32
14.58
3.1
2.3
31.4
36.1
u/l
0.58
98
480
133
663
2.21
14.14
9.7
6.8
105.1
104.3
mmol/l
1.42
133
652
743
6620
3.24
13.85
18.5
13.5
139.6
139.6
mmol/l
0.06
734
6448
743
6633
3.20
13.54
18.6
13.6
3.9
3.9
mmol/l
1.73
733
6447
534
4249
1.80
12.95
5.0
4.1
439.7
1907.6
e6/l
—
6
61
138
724
2.10
12.81
6.1
5.1
1.0
1.0
mmol/l
0.21
126
670
95
439
2.32
12.03
3.8
3.5
77.7
79.9
ng/l
0.12
79
396
151
858
1.94
11.13
2.0
1.7
1.4
1.4
%
0.44
136
772
241
1587
1.75
11.01
1.4
1.2
0.6
1.7
u/ml
2.25
72
437
151
875
1.90
10.44
2.0
2.3
124.8
113.2
ug/g
0.18
116
695
153
895
1.88
10.27
3.4
2.7
3.1
3.1
e6/l
0.00
80
468
228
1510
1.72
10.06
2.2
1.7
1.1
1.1
mg/l
0.01
179
1133
238
1610
1.69
9.65
3.4
2.8
0.3
0.4
e6/l
0.41
164
1188
113
609
2.00
9.63
9.3
7.8
5.2
5.1
kpa
0.58
113
584
158
953
1.82
9.57
2.7
2.5
0.9
1.1
e6/l
0.25
82
524
111
606
1.97
9.10
9.1
7.9
0.4
1.2
mmol/l
1.32
94
474
226
1535
1.66
8.91
2.4
2.0
2.7
2.9
mg/l
0.71
193
1320
31
98
3.25
8.16
1.3
1.3
—
—
—
0
0
152
956
1.73
7.88
3.7
3.0
0.8
0.8
mmol/l
0.10
138
897
105
592
1.89
7.80
4.3
4.3
226.2
239.2
u/l
0.68
100
563
20
49
4.16
7.57
1.5
1.2
—
—
—
0
0
297
2226
1.54
7.48
3.2
3.3
26.5
31.7
ng/l
0.32
176
1365
89
483
1.95
7.40
2.9
2.3
80.6
70.3
ml/min/173m2
1.32
37
203
166
1087
1.67
7.38
3.4
3.4
1651.3
285.5
ng/l
0.48
112
759
222
1573
1.57
7.13
3.0
2.5
1456.1
5762.9
umol/l
2.10
197
1366
111
658
1.80
7.02
26.6
18.8
1.3
1.2
inr
—
10
89
277
2070
1.52
6.96
3.0
3.2
2.4
2.4
mmol/l
1.09
242
1836
119
725
1.76
6.85
8.3
6.2
—
—
—
0
0
22
65
3.45
6.46
1.4
1.2
39.5
50.1
u/l
1.08
15
45
385
3118
1.46
6.32
3.9
2.7
112.4
97.6
ug/l
0.77
365
2918
746
7004
2.28
6.30
13.5
9.5
28.6
25.3
u/l
4.77
731
6787
342
2716
1.46
6.17
2.9
2.2
73.1
75.9
nmol/l
1.14
312
2467
26
89
2.99
6.05
1.0
1.0
0.1
0.1
u/ml
—
8
19
308
2411
1.46
5.93
2.1
1.9
101.2
96.0
pmol/l
0.98
175
1275
42
187
2.32
5.84
1.5
1.4
290.2
304.5
ug/g
0.15
22
109
34
138
2.53
5.77
1.1
1.1
0.8
1.6
u/ml
0.79
12
50
55
276
2.07
5.71
2.0
2.2
42.1
40.3
u/l
0.31
50
252
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
35
146
2.46
5.62
4.3
2.7
0.3
0.4
u/ml
1.84
16
74
49
237
2.14
5.60
1.7
1.7
—
—
—
0
0
197
1427
1.51
5.54
1.7
1.6
—
—
—
0
0
79
457
1.81
5.41
1.2
1.3
116.6
201.3
u/ml
0.82
72
419
71
403
1.84
5.18
1.5
1.7
—
—
—
0
0
673
6189
1.61
5.17
14.8
11.0
86.9
85.2
ml/min/173m2
1.14
567
5042
152
1058
1.54
5.12
2.9
2.7
2.5
2.4
mmol/l
1.57
137
932
75
438
1.79
4.99
2.0
2.4
7.7
6.2
ug/l
0.26
66
389
388
3239
1.39
4.92
5.2
4.5
0.0
0.0
estimate
0.50
56
630
18
57
3.21
4.79
1.2
1.0
—
—
—
0
0
391
3280
1.38
4.76
3.9
3.3
0.0
0.0
estimate
0.50
53
611
386
3234
1.38
4.72
4.0
3.3
0.0
0.0
estimate
0.00
53
625
34
155
2.25
4.53
2.6
2.9
—
—
—
0
0
67
390
1.78
4.52
1.1
1.0
—
—
—
0
0
26
105
2.53
4.50
1.0
1.0
1.5
3.3
u/ml
0.80
13
31
41
203
2.08
4.46
1.3
1.3
—
—
—
0
0
28
118
2.42
4.44
1.0
1.0
0.4
1.8
u/ml
0.69
11
25
197
1486
1.43
4.40
2.8
3.0
1348.8
1054.9
ng/l
0.35
167
1239
15
45
3.38
4.34
2.3
3.0
—
—
—
0
0
18
61
3.00
4.30
1.3
1.7
—
—
—
0
0
583
5282
1.40
4.11
4.8
4.1
14.6
14.5
pmol/l
0.12
538
4865
34
162
2.15
4.09
6.2
3.9
3.8
3.8
mmol/l
0.40
34
150
167
1240
1.44
4.04
2.9
2.4
4.5
7.2
e6/l
2.58
140
1085
226
1774
1.38
3.97
2.1
2.0
152.5
207.2
u/l
0.57
213
1680
16
54
3.00
3.86
1.4
1.8
—
—
—
0
0
225
1785
1.36
3.67
3.6
3.1
7.7
7.6
mmol/l
0.11
199
1510
180
1377
1.40
3.66
1.6
1.5
19.2
21.1
nmol/l
1.05
152
1185
37
192
1.97
3.59
5.9
4.1
1.1
1.3
mmol/l
1.01
37
186
138
1014
1.44
3.51
1.7
1.7
1127.8
1196.4
nmol/l
0.41
108
777
663
6198
1.45
3.47
5.8
4.8
1.7
2.0
mu/l
0.93
621
5760
54
322
1.73
3.40
3.5
2.1
12.3
12.0
nmol/l
0.08
45
292
89
602
1.54
3.40
1.8
1.8
—
—
—
0
0
40
221
1.85
3.25
1.8
1.4
1.3
1.2
g/l
0.72
40
209
11
33
3.37
3.20
1.2
1.0
—
—
—
0
0
57
352
1.67
3.18
1.4
1.4
—
—
—
0
0
90
629
1.49
2.97
1.7
1.8
—
—
—
0
0
24
114
2.14
2.97
1.2
1.1
—
—
—
0
0
89
622
1.49
2.94
1.6
1.7
—
—
—
0
0
159
1235
1.36
2.91
1.3
1.3
28.1
31.7
iu/ml
0.15
44
397
211
1716
1.31
2.82
4.5
4.0
16.3
9.3
mg/mmol
0.63
150
1074
69
461
1.54
2.81
4.6
3.5
2.2
2.0
mmol/l
0.22
57
362
69
462
1.54
2.79
3.2
3.4
4.4
4.5
pmol/l
0.55
62
405
25
124
2.05
2.79
1.6
1.2
2.0
6.1
u/ml
1.00
12
43
49
302
1.66
2.78
1.6
1.7
—
—
—
0
0
28
147
1.94
2.68
1.2
1.2
—
—
—
0
0
632
5932
1.33
2.63
6.5
5.2
39.8
39.0
mmol/mol
1.11
598
5565
88
628
1.45
2.63
2.0
2.0
409.6
371.4
nmol/l
0.80
74
583
120
908
1.38
2.58
1.8
1.8
—
—
—
0
0
69
473
1.50
2.52
1.7
1.7
—
—
—
0
0
38
225
1.72
2.51
2.1
2.2
1.5
1.5
g/l
0.03
32
193
150
1182
1.33
2.49
1.3
1.3
19.3
11.2
u/ml
0.46
66
472
759
7382
1.82
2.48
26.3
18.3
134.5
134.9
g/l
0.45
752
7287
30
166
1.84
2.48
1.2
1.3
—
—
—
0
0
23
116
2.01
2.48
1.6
1.2
1.4
3.8
u/ml
—
8
36
173
1393
1.31
2.47
4.8
3.6
1.0
1.0
kg/l
0.54
21
191
600
5624
1.28
2.30
21.0
14.9
13.7
13.6
%
0.35
595
5526
12
47
2.58
2.28
1.6
1.3
—
—
—
0
0
684
6530
1.37
2.27
4.8
4.1
4.7
4.7
mmol/l
0.39
647
6124
8
23
3.50
2.27
1.5
1.2
—
—
—
0
0
7
18
3.91
2.25
1.0
1.1
92.7
103.9
%
—
7
18
7
18
3.91
2.25
1.0
1.1
—
—
—
0
0
5
9
5.58
2.21
1.6
1.8
—
—
—
0
0
659
6264
1.32
2.20
4.3
3.6
1.4
1.3
mmol/l
5.42
614
5823
7
19
3.71
2.15
1.0
1.1
—
—
—
0
0
680
6497
1.35
2.15
4.7
4.0
1.5
1.5
mmol/l
1.58
637
6067
37
230
1.64
2.09
6.0
3.5
24.6
24.2
mmol/l
0.46
32
207
177
1460
1.27
2.09
1.6
1.4
—
—
—
0
0
6
159
0.37
2.04
1.7
1.5
—
—
—
0
0
8
26
3.10
2.01
1.1
1.2
—
—
—
0
0
201
1690
1.25
2.01
1.7
1.6
1.6
1.4
mmol/l
2.28
184
1442
15
70
2.17
1.99
4.0
4.9
11.1
59.8
u/ml
—
5
23
60
422
1.46
1.98
1.3
1.3
—
34.2
—
0
23
17
84
2.05
1.97
1.3
1.3
—
—
—
0
0
6
16
3.77
1.93
3.0
1.8
59.2
56.7
ug/l
—
6
16
17
85
2.02
1.91
1.3
1.3
—
—
—
0
0
17
85
2.02
1.91
1.3
1.3
—
—
—
0
0
17
86
2.00
1.86
1.3
1.3
—
—
—
0
0
17
86
2.00
1.86
1.3
1.3
—
—
—
0
0
17
86
2.00
1.86
1.3
1.3
—
—
—
0
0
34
214
1.62
1.85
2.7
5.9
1.7
1.6
%
0.29
34
199
287
2527
1.21
1.84
4.3
3.4
—
—
—
0
0
7
23
3.06
1.80
1.1
1.2
—
—
—
0
0
97
754
1.33
1.79
4.4
4.0
31.3
32.3
%
0.34
64
524
33
209
1.60
1.76
1.8
2.1
5.3
3.1
ug/l
0.21
26
186
42
610
0.67
1.76
3.2
3.1
—
—
—
0
0
52
368
1.44
1.69
1.7
2.0
5712.2
4039.4
u/l
0.18
15
153
30
188
1.62
1.68
1.5
1.3
—
—
—
0
0
687
6620
1.30
1.67
5.3
4.5
2.8
2.8
mmol/l
1.28
646
6178
8
31
2.60
1.66
1.5
2.5
4819.0
657.5
u/ml
—
8
31
8
31
2.60
1.66
3.5
2.7
—
—
—
0
0
29
182
1.62
1.62
1.4
1.2
1.6
3.0
u/ml
—
5
22
659
6325
1.26
1.60
4.8
4.2
5.9
5.8
mmol/l
0.77
617
5851
14
70
2.02
1.60
1.1
1.1
—
—
—
0
0
60
441
1.39
1.59
2.3
3.0
66.4
67.4
g/l
0.53
53
401
30
191
1.59
1.59
2.7
2.0
2.8
3.1
g/l
2.07
23
149
64
477
1.37
1.57
1.4
1.3
24.7
28.8
iu/l
0.49
54
413
33
216
1.55
1.56
1.5
1.6
0.1
0.0
iu/ml
—
10
37
16
85
1.90
1.56
1.0
1.1
—
—
—
0
0
12
57
2.12
1.55
1.1
1.2
—
—
—
0
0
29
186
1.58
1.50
1.4
1.2
5.1
10.7
u/ml
—
8
34
12
58
2.09
1.49
1.1
1.2
—
—
—
0
0
39
269
1.47
1.47
1.9
1.6
—
—
—
0
0
11
52
2.13
1.45
2.7
4.3
—
—
—
0
0
644
6186
1.23
1.42
20.1
13.0
39.8
39.9
%
0.05
500
4741
506
4758
1.18
1.41
3.7
3.4
—
—
—
0
0
45
325
1.41
1.35
1.5
1.5
—
—
—
0
0
15
83
1.82
1.32
1.1
1.2
0.5
0.5
nmol/l
0.34
15
78
6
24
2.51
1.30
1.3
1.7
—
—
—
0
0
6
24
2.51
1.30
1.3
1.7
—
—
—
0
0
6
24
2.51
1.30
1.3
1.8
—
—
—
0
0
30
203
1.50
1.26
2.7
1.9
—
—
—
0
0
30
203
1.50
1.26
2.7
1.9
3.7
3.8
g/l
0.16
23
145
30
203
1.50
1.26
2.7
1.9
6.7
7.4
g/l
1.82
23
155
33
229
1.46
1.24
1.4
2.0
—
—
—
0
0
5
19
2.64
1.21
1.8
1.5
—
—
—
0
0
5
19
2.64
1.21
1.2
1.9
—
—
—
0
0
0
34
0.00
1.16
0.0
2.6
—
—
—
0
0
92
757
1.24
1.14
3.1
2.8
0.9
0.7
ug/l
0.84
64
484
22
143
1.55
1.12
1.4
1.4
—
—
—
0
0
10
51
1.97
1.11
1.4
1.4
—
—
—
0
0
45
338
1.35
1.11
3.1
3.1
1.3
1.7
mmol/l
0.30
36
253
123
1048
1.21
1.10
4.3
4.1
21.3
21.6
%
0.12
71
471
27
185
1.48
1.09
2.9
2.0
9.9
10.7
g/l
0.56
22
160
14
81
1.74
1.09
1.4
1.6
—
—
—
0
0
47
357
1.34
1.08
3.1
3.2
5.2
5.1
kpa
0.16
40
338
5
22
2.28
1.03
1.0
1.0
—
—
—
0
0
10
53
1.90
1.01
1.5
1.4
—
—
—
0
0
9
48
1.88
1.00
1.1
1.2
—
—
—
0
0
194
1735
1.16
0.99
4.8
3.6
0.0
0.0
estimate
1.08
54
619
149
1306
1.17
0.98
5.5
4.7
2.8
2.2
ug/l
0.63
138
1165
118
1014
1.19
0.98
2.2
2.1
—
—
—
0
0
16
100
1.61
0.97
1.4
1.7
—
—
—
0
0
9
50
1.81
0.97
1.9
1.8
—
—
—
0
0
21
141
1.50
0.95
1.5
1.6
—
—
—
0
0
18
117
1.55
0.94
1.3
1.2
176.5
274.1
u/ml
—
8
71
6
28
2.15
0.91
1.7
1.7
—
—
—
0
0
6
28
2.15
0.91
1.7
1.7
—
—
—
0
0
20
135
1.49
0.90
2.9
2.4
78.0
129.0
ug/min
0.38
13
80
19
127
1.51
0.89
1.3
1.2
—
—
—
0
0
12
192
0.62
0.87
2.3
1.7
—
—
—
0
0
8
44
1.83
0.86
1.1
1.2
—
—
—
0
0
6
31
1.94
0.84
1.0
1.1
0.3
0.3
g/l
—
6
26
8
45
1.79
0.84
1.0
1.2
—
—
—
0
0
10
57
1.76
0.84
1.3
1.6
—
—
—
0
0
10
57
1.76
0.84
1.3
1.6
—
—
—
0
0
10
57
1.76
0.84
1.3
1.6
—
—
—
0
0
27
197
1.38
0.83
1.2
1.2
11.6
11.8
u/l
0.03
18
157
17
113
1.52
0.82
1.6
1.3
93.5
113.8
u/ml
—
5
26
11
65
1.70
0.82
1.1
1.1
—
—
—
0
0
11
65
1.70
0.82
1.1
1.1
—
—
—
0
0
16
105
1.53
0.82
1.3
1.6
—
—
—
0
0
16
105
1.53
0.82
1.1
1.3
—
—
—
0
0
16
105
1.53
0.82
1.1
1.3
—
—
—
0
0
105
912
1.17
0.79
2.0
1.9
—
—
—
0
0
37
472
0.77
0.79
1.4
1.5
—
—
—
0
0
11
66
1.68
0.79
1.1
1.1
—
—
—
0
0
11
66
1.68
0.79
1.1
1.1
—
—
—
0
0
11
66
1.68
0.79
1.1
1.1
—
—
—
0
0
21
148
1.43
0.78
1.4
1.6
—
—
—
0
0
6
34
1.77
0.76
1.3
1.6
—
—
—
0
0
6
34
1.77
0.76
1.3
1.6
—
—
—
0
0
6
34
1.77
0.76
1.3
1.6
—
—
—
0
0
6
34
1.77
0.76
1.3
1.6
—
—
—
0
0
20
142
1.42
0.73
1.5
1.5
—
—
—
0
0
141
1262
1.14
0.72
1.6
1.7
414.0
31814382.4
pmol/l
1.57
122
1075
7
39
1.80
0.72
2.1
1.6
—
—
—
0
0
9
57
1.59
0.71
1.0
1.0
180.2
219.1
mg/l
—
9
46
5
26
1.93
0.70
1.0
2.8
—
—
—
0
0
26
195
1.34
0.70
1.3
1.2
—
—
—
0
0
9
58
1.56
0.70
1.1
1.5
1.5
1.5
nmol/l
—
9
51
8
128
0.62
0.64
1.9
4.0
59.0
57.1
%
—
8
128
21
280
0.74
0.64
1.5
1.9
—
—
—
0
0
24
181
1.34
0.63
1.2
1.1
—
—
—
0
0
38
307
1.25
0.62
1.4
1.4
—
—
—
0
0
5
30
1.67
0.61
1.2
1.2
—
—
—
0
0
5
30
1.67
0.61
1.2
1.2
—
—
—
0
0
25
193
1.31
0.58
1.3
1.2
—
—
—
0
0
8
54
1.49
0.57
1.0
1.0
—
—
—
0
0
6
36
1.67
0.56
1.3
1.2
—
—
—
0
0
21
160
1.32
0.54
1.1
1.3
4.0
3.7
mmol/l
0.60
21
147
6
39
1.54
0.53
1.0
1.2
—
—
—
0
0
6
40
1.50
0.51
3.0
2.3
645.5
546.4
ml
—
6
21
20
154
1.31
0.49
1.4
1.4
23.9
28.3
u/l
0.24
15
129
29
235
1.24
0.48
1.8
1.8
—
—
—
0
0
11
76
1.45
0.48
1.1
1.2
—
—
—
0
0
17
222
0.76
0.48
1.5
1.5
—
—
—
0
0
21
266
0.78
0.47
1.3
1.4
—
—
—
0
0
21
266
0.78
0.47
1.3
1.4
—
—
—
0
0
12
85
1.42
0.47
1.6
1.5
—
—
—
0
0
37
310
1.20
0.46
1.4
1.7
4.0
3.2
mg/l
0.24
28
211
16
120
1.34
0.46
1.9
1.5
—
—
—
0
0
21
265
0.79
0.46
1.3
1.4
—
—
—
0
0
21
265
0.79
0.46
1.3
1.4
—
—
—
0
0
7
49
1.43
0.46
1.6
1.6
—
—
—
0
0
26
211
1.24
0.44
1.7
1.7
—
—
—
0
0
18
139
1.30
0.44
1.1
1.4
0.3
0.4
nmol/l
0.65
13
111
22
175
1.26
0.43
1.1
1.4
467.8
436.8
mg/l
0.13
22
163
5
32
1.57
0.42
1.0
1.1
100.8
115.1
%
—
5
27
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
5
32
1.57
0.42
1.6
2.1
182.1
121.5
%
—
5
32
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
63
560
1.14
0.40
1.2
1.2
151.2
160.1
iu/ml
0.05
23
231
5
34
1.47
0.40
1.4
1.4
5.1
5.7
mmol/l
—
5
34
5
34
1.47
0.40
1.0
1.8
—
69.4
—
0
5
0
19
0.00
0.39
0.0
1.7
—
2.1
—
0
7
13
98
1.33
0.37
1.1
1.1
—
—
—
0
0
10
72
1.39
0.37
1.3
1.2
—
—
—
0
0
6
43
1.40
0.35
2.7
1.4
—
—
—
0
0
17
138
1.24
0.30
1.6
1.6
6111.9
15400.7
e6/l
—
10
104
16
129
1.25
0.30
1.6
1.7
—
—
—
0
0
7
54
1.30
0.30
1.4
1.1
—
79.0
—
0
6
10
77
1.30
0.26
1.1
1.6
—
—
—
0
0
5
72
0.69
0.26
1.0
1.1
—
—
—
0
0
13
105
1.24
0.25
2.1
1.6
—
—
—
0
0
25
286
0.87
0.24
1.4
1.5
—
—
—
0
0
5
41
1.22
0.22
1.2
1.3
—
—
—
0
0
35
315
1.12
0.21
1.3
1.6
251.5
312.2
mu/l
1.15
30
284
29
325
0.89
0.21
1.6
1.4
—
—
—
0
0
5
42
1.19
0.21
1.8
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
5
43
1.16
0.21
1.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
2.3
—
—
—
0
0
6
48
1.25
0.20
1.7
1.1
—
1.0
—
0
18
12
99
1.22
0.19
1.2
1.1
—
—
—
0
0
11
90
1.23
0.19
1.1
1.2
—
—
—
0
0
14
118
1.19
0.19
1.3
1.1
—
11.6
—
0
13
13
109
1.20
0.18
1.3
1.1
—
—
—
0
0
7
63
1.11
0.17
1.6
1.7
—
—
—
0
0
11
92
1.20
0.16
1.1
1.6
—
—
—
0
0
51
480
1.07
0.14
4.5
3.5
1.2
1.2
mmol/l
0.28
46
414
21
190
1.11
0.13
1.5
2.0
1.8
4.9
iu/l
—
5
73
7
65
1.08
0.08
2.9
2.8
13.3
60.2
u/ml
—
7
65
30
284
1.06
0.07
1.1
1.3
221.1
247.1
miu/ml
0.23
16
137
7
82
0.85
0.07
1.1
1.1
—
—
—
0
0
67
689
0.97
0.06
1.5
1.6
—
—
—
0
0
17
162
1.05
0.02
1.2
1.3
—
—
—
0
0
41
402
1.02
0.01
1.5
1.4
—
—
—
0
0
12
126
0.95
0.00
1.8
1.8
—
—
—
0
0
17
165
1.03
0.00
1.5
1.5
—
—
—
0
0
10
102
0.98
0.00
1.2
1.1
—
72.8
—
0
25
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
3.1
—
0.5
—
0
8
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
13
130
1.00
0.00
1.0
1.0
1.6
2.2
u/ml
—
6
63
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
94.3
—
0
7
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
2.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_LIVER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_LIVER | 1.688 [1.43, 2.0] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.509 |
During the follow-up period (1.1.1998 — 31.12.2019), 253 out of 2095 females with CD2_BENIGN_LIVER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_LIVER | 1.949 [1.56, 2.44] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.054 |
During the follow-up period (1.1.1998 — 31.12.2019), 245 out of 876 males with CD2_BENIGN_LIVER died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_LIVER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.149% | 0.446% |
| 5 | 0.979% | 2.341% |
| 10 | 2.673% | 6.015% |
| 15 | 5.274% | 11.44% |
| 20 | 9.294% | 19.489% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_LIVER – Benign neoplasm: Liver
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data