liver neoplasm: A benign or malignant epithelial neoplasm that affects the liver parenchyma and intrahepatic bile ducts. Representative examples of benign epithelial neoplasms include hepatocellular adenoma and intrahepatic bile duct adenoma. Representative examples of malignant epithelial neoplasms include hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
899 |
4. Check minimum number of eventsNone |
899 |
5. Include endpointsNone |
899 |
6. Filter based on genotype QC (FinnGen only) |
875 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D13
- Name in latin
- Neoplasma benignum hepatis
Similar endpoints
↥List of similar endpoints to
Benign neoplasm: Liver
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm: Liver/bile ducts
- Benign neoplasm of other and ill-defined parts of digestive system
- Benign neoplasms
- Neoplasms
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3928 | 2744 | 1154 |
| Only index persons | 3579 | 2565 | 1014 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.08 | 0.03 |
| Only index persons | 0.08 | 0.09 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 51.46 | 48.25 | 58.77 |
| Only index persons | 50.04 | 46.94 | 57.87 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 875 | 653 | 222 |
| Unadjusted period prevalence (%) | 0.20 | 0.23 | 0.10 |
| Median age at first event (years) | 52.28 | 48.83 | 62.43 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 899
- Matched controls
- 8990
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D37.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Liver, gallbladder and bile ducts
57.1
307.7
211
48
D13.4
ICD-10 Finland
Benign neoplasm: Liver
4503599627370496.0
307.7
887
*
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
29.0
257.5
180
77
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
20.5
162.6
129
73
R93.2
ICD-10 Finland
Abnormal findings on diagnostic imaging of liver and biliary tract
36.7
108.1
68
20
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
15.7
106.4
95
67
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.2
80.1
193
449
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
18.8
62.4
50
28
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.6
42.5
448
2493
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.3
40.4
175
606
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.8
37.7
247
1076
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
6.4
36.7
63
105
D18.0
ICD-10 Finland
Haemangioma, any site
7.1
36.4
56
83
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
7.0
31.7
49
73
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.2
29.0
127
438
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
27.3
298
1613
UJF32
NOMESCO Finland
Coloscopy
2.2
21.7
247
1339
JN3KE
NOMESCO Finland
Abdominal ultrasound with added contrast
18.8
20.5
31
17
JN3AD
NOMESCO Finland
Abdominal CT examination
2.7
20.0
123
507
K76.9
ICD-10 Finland
Liver disease, unspecified
7.4
19.2
28
39
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
4.5
18.4
45
103
WX302
NOMESCO Finland
Thoracal epidural anesthesy
3.5
17.4
62
187
K76.89
ICD-10 Finland
Other specified diseases of liver
19.7
16.9
25
13
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.9
16.7
270
1640
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
17.6
15.7
24
14
J01MA02
ATC
ciprofloxacin; systemic
1.8
15.6
343
2285
K76.80
ICD-10 Finland
Hepatic cyst
12.6
15.4
27
22
A02BC02
ATC
pantoprazole; systemic
1.8
15.1
602
4754
N02AX02
ATC
tramadol; systemic, rectal
1.8
15.0
382
2649
A02BC05
ATC
esomeprazole; systemic
1.8
14.5
375
2608
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
14.2
243
1493
JN1CD
NOMESCO Finland
Very extensive CT examination of upper part of abdomen
14.7
14.1
23
16
JN4CD
NOMESCO Finland
Very extensive body CT
4.1
14.0
39
99
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
13.5
214
1281
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
13.1
194
1133
D41.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Kidney
4.7
12.9
30
66
JJB71
NOMESCO Finland
Laparoscopic resection of liver
50.8
12.9
15
*
21150
ICD-8 Finland
Benign neoplasm of other parts of digestive system, Hepatis
+∞
12.5
12
*
8170/3-C22.0
ICD-O-3
Hepatocellular carcinoma, NOS, of liver
27.1
12.1
16
6
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.2
11.9
48
157
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
11.8
367
2644
WX402
NOMESCO Finland
General anaesthesia
1.8
11.6
200
1223
R07.0
ICD-10 Finland
Pain in throat
2.4
11.4
79
344
ZXE20
NOMESCO Finland
More than three and less than five hours
2.1
11.3
121
630
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.8
11.0
56
209
JJ3AT
NOMESCO Finland
Cytology of liver with ultrasound guidance
43.9
10.9
13
*
JJB50
NOMESCO Finland
Excision of segments V, VI, VII and VIII of liver
43.9
10.9
13
*
JN1BD
NOMESCO Finland
Extensive CT examination of upper part of abdomen
15.7
10.9
17
11
R06.0
ICD-10 Finland
Dyspnoea
1.7
10.8
230
1492
A02BC03
ATC
lansoprazole; oral
1.7
10.7
250
1663
A02BC01
ATC
omeprazole; systemic
1.7
10.6
242
1598
130
Kela drug reimbursment
Malignant tumour
2.4
10.1
71
311
XKD00
NOMESCO Finland
Uroflowmetry
2.1
9.9
99
501
B01AB04
ATC
dalteparin; parenteral
2.7
9.9
53
203
R42
ICD-10 Finland
Dizziness and giddiness
1.8
9.9
184
1146
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
3.5
9.8
33
96
R4110
NOMESCO Finland
Physiotherapy
1.7
9.6
234
1566
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.0
9.4
114
619
JN3CG
NOMESCO Finland
Extensive MRI examination of abdomen with high intensity magnet
12.5
9.4
16
13
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
9.4
172
1065
D01
ICPC
Abdominal pain/cramps general
2.0
9.3
115
628
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
2.0
9.3
108
577
J01DB01
ATC
cefalexin; oral
1.8
9.3
741
6545
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.3
9.2
70
317
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.9
9.2
130
743
JKA20
NOMESCO Finland
Cholecystectomy
3.7
9.0
28
77
C22.9
ICD-10 Finland
Malignant neoplasm: Liver, unspecified
24.3
8.9
12
5
UJF30
NOMESCO Finland
Ileoscopy through colon
2.1
8.8
91
467
JN3DG
NOMESCO Finland
Very extensive MRI examination with high intensity magnet
14.2
8.7
14
10
UKC02
NOMESCO Finland
Cystoscopy
1.9
8.6
112
622
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.8
8.6
134
790
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
4.2
8.5
22
53
H53.1
ICD-10 Finland
Subjective visual disturbances
2.3
8.4
64
290
B01AB05
ATC
enoxaparin; parenteral
1.6
8.4
256
1805
Z3231
NOMESCO Finland
Registered nurse
1.6
8.3
229
1573
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.8
8.3
125
728
P01AB01
ATC
metronidazole; oral, rectal
1.5
8.3
375
2880
JJB30
NOMESCO Finland
Excision of two segments of liver
33.7
8.1
10
*
N02BE01
ATC
paracetamol; systemic, rectal
1.8
8.1
783
7095
JJA21
NOMESCO Finland
Laparoscopic biopsy of liver
22.2
8.0
11
5
K86.2
ICD-10 Finland
Cyst of pancreas
7.3
8.0
18
25
R30.0
ICD-10 Finland
Dysuria
2.6
7.9
44
172
ZXD10
NOMESCO Finland
Scheduled procedure
1.5
7.9
322
2414
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.5
7.7
291
2144
JN1AE, ,
SPAT
2.6
7.6
43
170
A04
ICPC
Weakness/tiredness general
1.8
7.6
123
733
J01MA12
ATC
levofloxacin; systemic
1.7
7.5
143
893
XF400
NOMESCO Finland
ECG with 12 standard connections
1.8
7.4
115
675
M54
ICD-10 Finland
Dorsalgia
1.8
7.4
117
692
R51.80
ICD-10 Finland
Headache
1.7
7.4
152
969
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.8
7.3
118
703
JJB10
NOMESCO Finland
Atypcal resection of liver
15.9
7.2
11
7
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
2.0
7.2
82
435
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.9
7.2
91
501
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
7.2
471
3861
A06AC01
ATC
ispaghula (psylla seeds); oral
1.6
7.2
214
1493
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
3.5
7.2
24
70
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
2.1
7.1
63
305
N03AX12
ATC
[U] gabapentin; oral
1.7
7.1
141
889
A03FA01
ATC
metoclopramide; systemic, rectal
1.6
7.1
197
1352
LBE01
NOMESCO Finland
Laparoscopic salpingectomy
3.0
7.1
31
107
D12.2
ICD-10 Finland
Benign neoplasm: Ascending colon
3.1
7.1
28
91
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.9
7.0
92
512
KBV02
NOMESCO Finland
Cystoscopic insertion of stent into ureter
3.9
7.0
20
52
WZC00
NOMESCO Finland
Treatment plan or consultation
1.5
7.0
310
2353
N03AX16
ATC
[U] pregabalin
1.6
7.0
193
1323
C22.1
ICD-10 Finland
Malignant neoplasm: Intrahepatic bile duct carcinoma
13.9
6.9
11
8
SPAT1360
SPAT
Extensive global examination
2.2
6.9
55
255
JN3AE, ,
SPAT
2.6
6.9
38
149
R01AD58
ATC
fluticasone, combinations; nasal
1.5
6.8
234
1682
LCD04
NOMESCO Finland
Laparoscopic hysterectomy
2.5
6.8
40
162
Z71.8
ICD-10 Finland
Other specified counselling
1.5
6.7
276
2058
K30
ICD-10 Finland
Functional dyspepsia
1.8
6.7
107
634
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.0
6.7
70
361
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.7
6.6
122
755
D13.6
ICD-10 Finland
Benign neoplasm: Pancreas
10.1
6.5
12
12
C08CA01
ATC
amlodipine; oral
1.5
6.5
259
1916
M03BX02
ATC
tizanidine; oral
1.4
6.5
553
4723
M01AE03
ATC
ketoprofen; systemic, rectal
1.5
6.5
292
2216
Z3226
NOMESCO Finland
Physiotherapist
1.6
6.5
151
992
A02BA02
ATC
ranitidine; systemic
1.6
6.5
149
976
JN3GE
NOMESCO Finland
Intraoperative ultrasound examination of abdomen
70.3
6.4
7
*
M79.6
ICD-10 Finland
Pain in limb
1.4
6.4
359
2841
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
2.3
6.3
45
199
D13.1
ICD-10 Finland
Benign neoplasm: Stomach
3.4
6.3
22
66
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
2.9
6.3
28
98
XX9KE
NOMESCO Finland
Ultrasound examination with contrast
26.9
6.2
8
*
XJA00
NOMESCO Finland
Intraoperative abdominal ultrasonography
26.9
6.2
8
*
R01AD09
ATC
mometasone; nasal
1.4
6.2
415
3382
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
2.1
6.2
60
301
R53
ICD-10 Finland
Malaise and fatigue
1.5
6.2
201
1425
D11
ICPC
Diarrhoea
1.7
6.2
110
673
D06
ICPC
Abdominal pain localized other
1.9
6.1
76
416
A10AB05
ATC
insulin aspart; parenteral
2.0
6.1
63
323
D07AC01
ATC
betamethasone; topical
1.5
6.1
292
2236
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.8
6.1
91
528
JAH00
NOMESCO Finland
Laparotomy
2.9
6.0
28
100
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
172
221
9.39
129.83
2.2
3.2
21.66
1310.54
u/ml
0.98
152
191
282
620
6.17
129.06
2.5
4.2
2.65
15.15
ug/l
1.11
191
501
669
3669
4.22
82.47
6.8
5.8
10.42
10.50
umol/l
0.10
644
3483
94
111
9.34
74.72
1.9
4.0
128.38
2645.20
u/ml
0.60
87
105
224
640
4.33
71.37
2.5
2.2
0.23
0.22
g/l
0.95
217
605
250
796
3.97
68.32
3.8
2.4
5.12
6.69
umol/l
2.12
222
686
538
2871
3.18
62.25
5.5
4.4
36.36
36.27
g/l
0.16
509
2696
380
1761
3.01
54.82
5.4
3.4
97.01
94.31
%
1.21
371
1702
525
2923
2.91
53.40
12.6
11.1
1.16
1.17
inr
0.08
114
910
787
5589
4.28
50.92
9.3
7.0
79.76
75.90
u/l
2.31
759
5270
401
2251
2.41
35.60
3.2
2.4
56.27
59.08
u/l
0.42
369
2098
426
2511
2.32
33.15
4.1
3.1
30.46
29.95
u/l
0.16
412
2395
583
4063
2.24
28.51
6.1
4.4
6.58
6.54
mmol/l
0.16
557
3742
316
1739
2.26
27.87
2.6
2.1
—
—
—
0
0
513
3508
2.08
24.90
2.8
2.4
—
—
—
0
0
125
495
2.77
22.09
8.5
7.2
7.66
8.77
mmol/l
0.92
119
471
673
5217
2.15
21.81
4.4
2.9
61.50
42.24
u/l
7.03
650
4934
182
886
2.32
20.73
3.0
2.2
23.66
23.31
%
0.12
166
764
192
966
2.26
20.18
2.9
2.2
2.50
2.38
g/l
1.40
179
894
691
5486
2.12
19.92
4.3
3.9
12.24
10.74
mm/h
1.76
647
5116
576
4292
1.95
19.86
8.5
8.6
4.37
3.99
e9/l
3.11
499
3783
203
1056
2.19
19.61
2.9
2.2
14.04
13.75
umol/l
0.24
194
979
142
641
2.44
19.08
3.1
2.4
31.33
37.99
u/l
0.88
117
539
857
7544
3.91
18.95
16.9
12.1
23.41
20.99
mg/l
1.26
749
5900
434
3002
1.86
18.25
7.5
5.4
1.22
1.22
mmol/l
0.06
401
2747
468
3332
1.84
17.77
8.8
6.1
1.22
1.22
mmol/l
0.05
422
2827
853
7551
3.53
17.35
18.4
13.3
139.63
139.62
mmol/l
0.03
843
7351
853
7568
3.48
16.93
18.5
13.4
3.92
3.94
mmol/l
1.89
842
7355
150
748
2.21
15.84
9.2
6.9
105.25
104.36
mmol/l
1.98
150
748
616
4874
1.84
15.60
4.9
4.1
439.67
1824.64
e6/l
—
6
64
261
1606
1.88
15.31
1.8
1.4
2.14
2.26
g/l
0.55
173
1010
485
3607
1.75
14.87
6.3
5.6
28.82
28.63
%
0.15
462
3405
479
3569
1.73
14.42
6.1
5.4
57.54
56.84
%
0.70
457
3365
107
487
2.36
13.96
3.7
3.6
84.87
79.59
ng/l
0.22
90
442
287
1869
1.79
13.75
1.3
1.3
0.60
1.80
u/ml
2.97
81
516
180
1012
1.97
13.67
3.4
2.7
3.06
3.18
e6/l
0.05
93
515
154
820
2.06
13.61
6.7
5.1
1.04
1.02
mmol/l
0.32
142
760
269
1727
1.80
13.48
2.2
1.7
0.99
1.02
mg/l
0.07
210
1294
178
1009
1.95
13.16
2.0
2.4
117.09
112.59
ug/g
0.08
137
804
186
1079
1.91
12.81
2.8
2.6
0.91
1.07
e6/l
0.31
96
578
276
1824
1.74
12.33
3.5
2.9
0.28
0.37
e6/l
0.40
190
1350
296
2003
1.71
12.10
3.8
3.0
53.63
100.56
e6/l
0.55
214
1510
126
653
2.08
11.91
4.0
4.1
228.97
240.05
u/l
0.60
120
621
171
987
1.90
11.89
1.9
1.7
1.43
1.40
%
0.28
152
887
195
1199
1.80
11.02
3.3
3.4
1385.48
270.32
ng/l
0.46
134
829
325
2348
1.60
9.86
3.1
3.2
2.37
2.35
mmol/l
1.50
284
2089
123
675
1.95
9.85
8.7
7.9
0.38
1.13
mmol/l
1.55
103
537
260
1784
1.64
9.71
2.4
2.0
2.75
2.89
mg/l
0.48
221
1529
35
108
3.33
9.53
1.3
1.3
—
—
—
0
0
361
2715
1.55
9.00
2.1
1.9
102.14
96.31
pmol/l
1.26
203
1444
100
535
1.98
8.60
8.8
7.2
1.35
1.29
mmol/l
0.18
100
523
400
3099
1.52
8.59
2.8
2.3
72.67
76.09
nmol/l
1.74
368
2821
23
57
4.11
8.56
1.7
1.2
—
—
—
0
0
253
1775
1.59
8.45
2.9
2.4
1319.93
5733.33
umol/l
2.50
224
1561
858
8012
2.55
8.40
13.6
9.5
28.68
25.46
u/l
4.74
843
7768
335
2514
1.53
8.26
3.3
3.2
27.12
34.35
ng/l
0.49
193
1529
169
1086
1.68
7.97
4.1
3.0
0.83
0.82
mmol/l
0.25
154
1024
780
7098
1.75
7.43
14.9
10.9
87.39
86.07
ml/min/173m2
0.91
655
5804
180
1200
1.63
7.31
2.9
2.6
2.45
2.43
mmol/l
1.52
161
1059
98
550
1.88
7.31
2.8
2.2
79.07
71.79
ml/min/173m2
0.88
43
220
446
3627
1.46
7.05
3.8
2.7
107.81
99.05
ug/l
0.42
423
3397
132
823
1.71
6.92
7.9
6.1
—
—
—
0
0
231
1655
1.53
6.83
2.7
3.0
1341.54
1016.92
ng/l
0.46
193
1375
53
248
2.21
6.51
1.3
1.3
—
—
—
0
0
30
108
2.84
6.37
1.0
1.1
5.92
6.30
u/ml
0.03
12
38
29
103
2.88
6.31
1.0
1.0
0.09
0.09
u/ml
—
9
33
83
464
1.87
6.28
1.0
1.0
—
—
—
0
0
39
164
2.44
6.12
4.3
4.1
40.15
31.29
mg/l
0.37
33
132
680
6078
1.49
6.01
4.7
4.1
14.47
14.52
pmol/l
0.22
625
5605
62
320
2.01
5.93
2.2
2.1
42.63
39.65
u/l
0.62
57
289
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
38
161
2.42
5.88
4.1
2.7
0.27
0.38
u/ml
1.82
17
81
230
1701
1.47
5.72
1.7
1.6
—
—
—
0
0
38
164
2.38
5.65
4.4
4.1
46.12
90.70
mg/l
0.58
33
132
66
355
1.93
5.62
7.8
7.4
24.62
24.49
mmol/l
0.12
66
337
37
160
2.37
5.49
1.1
1.1
2.04
3.21
u/ml
0.46
16
79
78
447
1.82
5.47
1.5
1.6
—
—
—
0
0
45
215
2.15
5.29
1.5
1.5
300.96
305.19
ug/g
0.04
24
126
53
270
2.02
5.28
1.7
1.7
—
—
—
0
0
88
529
1.74
5.25
1.3
1.3
133.46
200.25
u/ml
0.63
81
489
76
439
1.80
5.20
2.0
2.8
132.57
166.36
ng/l
0.45
70
399
769
7118
1.56
5.13
5.8
4.8
1.71
1.98
mu/l
0.97
719
6616
30
122
2.51
5.08
1.0
1.0
1.46
3.10
u/ml
0.95
13
57
81
484
1.74
4.95
2.1
2.3
7.40
6.03
ug/l
0.24
71
431
440
3713
1.36
4.95
5.4
4.5
0.00
0.00
estimate
0.50
61
724
15
41
3.70
4.94
1.1
1.1
30.01
29.54
u/l
0.01
15
41
15
41
3.70
4.94
1.1
1.1
97.00
90.56
u/l
0.13
15
41
208
1549
1.45
4.91
1.6
1.5
19.26
21.00
nmol/l
1.02
176
1339
444
3762
1.36
4.82
3.9
3.3
0.00
0.01
estimate
0.80
58
702
439
3718
1.35
4.76
4.0
3.3
0.00
0.00
estimate
0.50
65
761
64
364
1.82
4.63
3.4
2.1
12.02
11.66
nmol/l
0.11
53
328
160
1146
1.48
4.60
1.7
1.7
1130.96
1205.51
nmol/l
0.51
123
879
19
65
2.96
4.46
1.2
1.0
—
—
—
0
0
188
1398
1.44
4.44
3.0
2.4
4.80
7.18
e6/l
2.31
163
1250
37
176
2.15
4.44
2.6
2.9
—
—
—
0
0
31
137
2.31
4.42
1.0
1.1
0.35
1.41
u/ml
1.52
13
67
255
2011
1.37
4.27
2.1
2.0
146.87
198.44
u/l
0.62
241
1902
59
336
1.81
4.26
1.6
1.7
—
—
—
0
0
46
245
1.92
4.09
1.9
2.1
1.44
1.46
g/l
0.06
37
211
82
522
1.63
3.99
5.1
3.4
2.12
1.95
mmol/l
0.25
71
421
256
2042
1.35
3.94
3.6
3.1
7.69
7.56
mmol/l
0.16
227
1742
14
37
3.83
3.90
2.8
3.0
43500.00
36510.95
ug/l
1.10
14
37
103
700
1.53
3.80
1.6
1.7
—
—
—
0
0
40
209
1.96
3.78
5.7
4.1
1.16
1.32
mmol/l
0.79
40
203
15
50
3.03
3.70
2.3
2.8
—
—
—
0
0
14
40
3.54
3.61
1.1
1.0
—
—
—
0
0
139
1018
1.43
3.54
1.7
1.8
—
—
—
0
0
102
703
1.51
3.53
1.7
1.8
—
—
—
0
0
15
52
2.92
3.47
1.5
1.3
—
—
—
0
0
722
6733
1.37
3.42
6.4
5.1
39.52
39.06
mmol/mol
0.64
684
6307
872
8457
2.04
3.40
26.6
18.0
40.14
40.13
%
0.02
839
7994
872
8463
2.01
3.30
26.1
18.0
268.22
258.01
e9/l
3.79
854
8277
872
8468
1.99
3.21
26.2
18.0
4.50
4.49
e12/l
0.31
855
8262
102
718
1.47
3.20
2.0
2.0
405.83
377.95
nmol/l
0.57
86
667
107
762
1.46
3.17
1.8
1.8
—
—
—
0
0
181
1413
1.35
3.15
1.3
1.3
27.00
31.80
iu/ml
0.23
47
469
62
392
1.62
3.14
1.4
1.4
—
—
—
0
0
872
8472
1.97
3.14
26.3
18.1
134.09
134.90
g/l
1.02
865
8366
79
535
1.52
3.00
3.0
3.4
4.44
4.55
pmol/l
0.51
69
466
44
257
1.75
2.99
1.7
1.5
1.26
1.19
g/l
0.76
44
242
26
127
2.08
2.99
1.2
1.1
—
—
—
0
0
214
1729
1.31
2.93
1.6
1.4
—
—
—
0
0
27
136
2.02
2.88
1.6
1.2
2.15
6.08
u/ml
1.11
13
48
6
9
6.70
2.87
1.7
1.8
—
—
—
0
0
34
186
1.86
2.86
1.2
1.2
—
—
—
0
0
172
1352
1.34
2.85
1.3
1.3
18.50
13.04
u/ml
0.29
69
548
53
331
1.64
2.84
2.0
1.8
—
—
—
0
0
18
77
2.36
2.83
1.3
1.7
—
—
—
0
0
37
209
1.80
2.82
1.3
1.2
1.50
2.70
u/ml
—
6
27
232
1904
1.29
2.82
1.7
1.6
1.58
1.37
mmol/l
2.22
212
1626
19
84
2.29
2.78
2.9
2.2
—
—
—
0
0
40
234
1.74
2.73
2.9
5.5
1.80
1.57
%
0.59
40
218
115
854
1.40
2.72
4.3
4.0
31.71
32.13
%
0.14
76
599
235
1941
1.29
2.71
4.6
3.8
18.57
9.09
mg/mmol
1.01
169
1222
37
213
1.77
2.67
1.3
1.2
4.84
9.68
u/ml
—
9
41
225
1854
1.28
2.64
3.9
3.3
759.93
404.21
mg/l
0.41
160
1184
780
7438
1.37
2.60
4.8
4.0
4.72
4.76
mmol/l
0.55
739
6986
8
20
4.03
2.57
1.0
1.1
94.50
102.55
%
—
8
20
16
68
2.38
2.56
1.4
1.8
—
—
—
0
0
194
1591
1.28
2.35
4.4
3.6
1.02
1.02
kg/l
0.18
26
215
31
177
1.78
2.33
2.7
1.9
38.22
38.80
g/l
0.20
25
161
24
126
1.93
2.32
1.6
1.2
1.38
3.63
u/ml
—
8
38
756
7206
1.31
2.29
4.8
4.1
5.88
5.82
mmol/l
0.64
708
6661
36
216
1.69
2.28
2.5
2.0
2.85
2.87
g/l
0.05
30
200
774
7403
1.33
2.27
4.7
4.0
1.46
1.50
mmol/l
1.93
723
6921
69
485
1.46
2.24
2.6
2.9
66.55
67.49
g/l
0.49
59
443
749
7137
1.30
2.22
4.3
3.6
1.39
1.25
mmol/l
5.35
695
6634
33
195
1.72
2.22
2.6
2.1
0.21
0.84
g/l
1.17
27
178
594
5517
1.23
2.20
3.8
3.4
—
—
—
0
0
24
129
1.88
2.18
3.1
7.6
103.08
105.39
mmol/l
1.27
24
116
37
227
1.66
2.18
1.5
1.3
—
—
—
0
0
81
591
1.41
2.16
1.7
1.7
—
—
—
0
0
28
160
1.77
2.12
1.2
1.2
—
—
—
0
0
38
243
1.59
1.93
1.6
1.6
0.13
0.03
iu/ml
—
10
43
783
7536
1.30
1.92
5.3
4.4
2.77
2.84
mmol/l
1.50
735
7049
13
58
2.26
1.91
2.6
4.1
—
—
—
0
0
36
228
1.60
1.90
2.5
1.9
3.77
3.56
g/l
0.49
29
212
36
228
1.60
1.90
2.5
1.9
7.19
7.36
g/l
0.25
30
212
36
228
1.60
1.90
2.5
1.9
—
—
—
0
0
75
555
1.38
1.87
1.5
1.3
24.75
27.97
iu/l
0.39
63
478
9
34
2.66
1.87
3.2
2.8
—
—
—
0
0
8
28
2.87
1.86
1.5
1.3
—
—
—
0
0
24
138
1.76
1.81
1.2
1.2
187.20
258.78
u/ml
—
10
87
9
35
2.59
1.80
1.6
2.3
4306.89
697.97
u/ml
—
9
35
63
456
1.41
1.79
1.7
2.0
5091.87
4001.92
u/l
0.14
19
186
33
208
1.61
1.79
2.6
2.0
10.20
10.53
g/l
0.23
27
191
6
18
3.35
1.75
3.0
2.1
59.23
54.49
ug/l
—
6
18
41
274
1.52
1.74
4.9
3.4
25.30
25.18
mmol/l
0.07
41
268
18
96
1.89
1.71
1.3
1.3
—
—
—
0
0
104
822
1.30
1.69
3.2
2.8
0.84
0.72
ug/l
0.55
74
533
18
97
1.87
1.67
1.3
1.3
—
—
—
0
0
18
97
1.87
1.67
1.3
1.3
—
—
—
0
0
7
25
2.81
1.65
1.0
1.1
—
—
—
0
0
18
98
1.85
1.62
1.3
1.3
—
—
—
0
0
36
238
1.53
1.62
1.2
1.2
10.65
10.97
u/l
0.05
24
192
12
56
2.16
1.61
1.8
1.4
—
—
—
0
0
25
151
1.67
1.61
1.2
1.2
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
8
32
2.51
1.60
1.9
2.1
175.31
121.47
%
—
8
32
15
77
1.96
1.60
1.1
1.2
—
—
—
0
0
35
231
1.54
1.59
1.8
2.0
5.14
2.83
ug/l
0.23
27
208
50
690
0.71
1.59
3.3
3.0
—
—
—
0
0
18
99
1.83
1.58
1.3
1.3
—
—
—
0
0
18
99
1.83
1.58
1.3
1.3
—
—
—
0
0
22
129
1.72
1.58
1.5
1.4
106.60
110.82
u/ml
—
6
28
8
33
2.44
1.54
1.1
1.4
—
—
—
0
0
53
385
1.40
1.51
3.3
3.1
1.34
1.72
mmol/l
0.40
40
283
17
94
1.82
1.48
1.0
1.1
—
—
—
0
0
55
405
1.38
1.45
3.3
3.1
5.07
5.13
kpa
0.24
49
390
15
80
1.89
1.45
4.0
4.7
11.12
57.17
u/ml
—
5
24
16
88
1.83
1.42
1.1
1.2
0.50
0.54
nmol/l
0.33
16
83
148
1248
1.22
1.41
2.2
2.1
—
—
—
0
0
7
29
2.42
1.39
1.6
1.7
—
—
—
0
0
7
29
2.42
1.39
1.6
1.7
—
—
—
0
0
7
29
2.42
1.39
1.1
1.4
—
—
—
0
0
7
29
2.42
1.39
2.3
2.7
—
—
—
0
0
11
208
0.52
1.34
1.4
1.5
—
—
—
0
0
49
360
1.38
1.33
1.4
1.5
—
—
—
0
0
319
2894
1.16
1.31
4.3
3.4
—
—
—
0
0
27
177
1.54
1.30
1.4
1.4
27.12
26.50
u/l
0.03
20
149
135
1141
1.22
1.27
4.3
4.1
21.65
21.83
%
0.06
78
522
19
115
1.67
1.25
1.1
1.3
—
—
—
0
0
19
115
1.67
1.25
1.1
1.3
—
—
—
0
0
5
19
2.64
1.21
1.0
1.3
—
—
—
0
0
5
19
2.64
1.21
1.0
1.1
—
—
—
0
0
31
215
1.46
1.17
1.2
1.1
—
—
—
0
0
48
361
1.35
1.16
1.4
1.7
4.28
3.54
mg/l
0.28
38
261
37
268
1.40
1.12
3.1
2.5
0.63
0.66
%
0.26
37
268
10
51
1.97
1.11
1.1
1.2
—
—
—
0
0
163
1421
1.18
1.11
5.6
4.7
2.80
2.29
ug/l
0.62
152
1267
5
21
2.39
1.09
1.2
2.0
—
—
—
0
0
8
41
1.96
1.09
2.0
1.7
—
—
—
0
0
132
1133
1.19
1.08
2.0
2.0
—
—
—
0
0
36
262
1.39
1.07
1.4
2.0
—
—
—
0
0
10
52
1.93
1.06
1.1
1.2
—
—
—
0
0
7
33
2.13
1.05
1.0
1.1
0.33
0.30
g/l
—
7
27
12
67
1.80
1.05
1.1
1.3
—
—
—
0
0
5
22
2.28
1.03
1.8
1.5
—
—
—
0
0
12
68
1.78
1.01
1.1
1.3
—
—
—
0
0
31
224
1.40
0.97
1.3
1.2
—
—
—
0
0
23
157
1.48
0.97
3.0
2.3
68.91
114.61
ug/min
0.40
15
96
6
27
2.23
0.93
1.0
1.0
—
—
—
0
0
10
55
1.83
0.92
1.1
1.2
—
—
—
0
0
20
134
1.50
0.92
1.3
1.1
—
11.65
—
0
13
6
29
2.08
0.89
1.3
1.9
—
—
—
0
0
6
29
2.08
0.89
1.3
1.9
—
—
—
0
0
6
29
2.08
0.89
1.3
1.9
—
—
—
0
0
19
127
1.51
0.89
1.5
1.6
—
—
—
0
0
19
127
1.51
0.89
1.5
1.6
—
—
—
0
0
49
387
1.28
0.88
1.4
1.5
—
—
—
0
0
15
95
1.59
0.87
1.3
1.6
—
—
—
0
0
35
264
1.34
0.87
1.9
1.9
—
—
—
0
0
32
238
1.36
0.87
1.8
1.8
—
—
—
0
0
26
187
1.40
0.86
1.2
1.4
462.04
434.22
mg/l
0.14
26
174
24
171
1.41
0.83
1.1
1.3
3.92
3.69
mmol/l
0.53
24
157
30
223
1.36
0.82
1.3
1.2
—
—
—
0
0
23
163
1.42
0.82
1.4
1.3
—
—
—
0
0
17
248
0.68
0.81
2.1
1.7
—
—
—
0
0
24
174
1.39
0.77
1.5
1.6
—
—
—
0
0
6
34
1.77
0.76
1.0
1.1
102.17
115.29
%
—
6
28
12
75
1.61
0.75
1.1
1.1
—
—
—
0
0
12
75
1.61
0.75
1.1
1.1
—
—
—
0
0
9
54
1.67
0.74
1.2
1.7
—
—
—
0
0
12
76
1.59
0.72
1.1
1.1
—
—
—
0
0
12
76
1.59
0.72
1.1
1.1
—
—
—
0
0
12
76
1.59
0.72
1.1
1.1
—
—
—
0
0
7
40
1.76
0.71
1.0
1.3
—
—
—
0
0
24
320
0.74
0.71
1.5
1.8
—
—
—
0
0
18
126
1.44
0.70
1.3
1.5
—
—
—
0
0
9
58
1.56
0.70
1.3
1.1
—
43.20
—
0
5
47
383
1.24
0.69
1.3
1.5
287.15
321.58
mu/l
0.31
41
347
76
651
1.18
0.68
1.3
1.2
146.09
151.05
iu/ml
0.03
25
276
9
59
1.53
0.68
1.3
1.1
—
68.00
—
0
7
13
86
1.52
0.66
1.2
1.2
—
—
—
0
0
23
171
1.35
0.66
1.3
1.4
0.26
0.34
nmol/l
0.67
15
138
11
70
1.58
0.65
1.5
1.4
—
—
—
0
0
10
62
1.62
0.65
1.1
1.5
1.41
1.51
nmol/l
—
10
55
10
62
1.62
0.65
1.8
1.7
—
—
—
0
0
214
1978
1.11
0.64
4.6
3.6
0.00
0.01
estimate
1.08
59
710
10
63
1.59
0.62
1.0
1.1
174.80
222.88
mg/l
—
10
51
8
50
1.61
0.61
1.1
1.3
—
—
—
0
0
13
88
1.48
0.60
1.5
1.5
—
—
—
0
0
13
88
1.48
0.60
1.5
1.5
—
—
—
0
0
157
1433
1.12
0.59
1.6
1.7
419.39
34511522.72
pmol/l
1.81
134
1217
18
131
1.38
0.59
1.3
1.1
—
—
—
0
0
16
114
1.41
0.59
1.9
1.6
—
—
—
0
0
19
140
1.36
0.58
1.5
1.6
—
—
—
0
0
0
23
0.00
0.58
0.0
1.9
—
1.75
—
0
10
9
61
1.48
0.54
1.0
1.1
—
—
—
0
0
6
39
1.54
0.53
1.0
1.7
—
69.40
—
0
5
22
170
1.30
0.52
1.5
1.6
—
—
—
0
0
6
40
1.50
0.51
1.3
1.7
—
—
—
0
0
6
40
1.50
0.51
1.3
1.7
—
—
—
0
0
23
180
1.29
0.50
1.3
1.5
—
—
—
0
0
10
67
1.50
0.50
1.3
1.6
—
—
—
0
0
10
67
1.50
0.50
1.3
1.6
—
—
—
0
0
10
67
1.50
0.50
1.3
1.1
31.50
38.26
mg/l
—
10
52
10
67
1.50
0.50
1.3
1.6
—
—
—
0
0
10
144
0.69
0.49
3.6
4.0
55.20
56.93
%
—
10
144
10
142
0.70
0.46
3.4
3.6
3.99
4.22
e9/l
—
10
142
16
120
1.34
0.46
1.4
1.7
—
—
—
0
0
40
338
1.19
0.46
1.2
1.3
235.12
241.52
miu/ml
0.05
21
164
7
50
1.40
0.45
1.9
1.6
—
—
—
0
0
8
56
1.43
0.42
2.3
1.4
—
—
—
0
0
22
176
1.26
0.42
1.4
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
2.1
—
—
—
0
0
5
35
1.43
0.39
1.2
1.2
—
—
—
0
0
5
35
1.43
0.39
1.2
1.2
—
—
—
0
0
15
115
1.31
0.39
1.1
1.1
—
—
—
0
0
53
593
0.89
0.34
1.4
1.5
—
—
—
0
0
14
110
1.28
0.32
1.1
1.2
—
—
—
0
0
7
53
1.32
0.31
1.0
1.4
—
—
—
0
0
16
129
1.24
0.30
1.9
1.5
—
—
—
0
0
26
222
1.18
0.29
1.6
1.9
2.23
4.86
iu/l
—
7
82
7
56
1.25
0.29
1.6
1.6
—
—
—
0
0
12
94
1.28
0.28
1.1
1.6
—
—
—
0
0
11
85
1.30
0.28
1.3
1.4
—
—
—
0
0
59
539
1.10
0.26
5.2
3.3
1.23
1.23
mmol/l
0.19
52
466
5
40
1.25
0.22
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
12
98
1.23
0.21
1.6
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
32.19
—
0
7
5
43
1.16
0.21
1.4
1.2
184.20
517.81
u/l
—
5
37
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
18
155
1.16
0.20
1.6
1.6
7282.64
14462.44
e6/l
0.79
11
116
12
144
0.83
0.20
3.3
4.3
23.01
23.68
mg/l
—
7
88
7
58
1.21
0.18
1.0
1.4
1.47
1.37
promille
—
7
44
26
289
0.90
0.17
1.5
1.6
—
—
—
0
0
84
797
1.06
0.17
1.5
1.6
—
—
—
0
0
13
111
1.17
0.16
1.1
1.5
—
—
—
0
0
8
73
1.10
0.15
2.8
2.7
12.25
54.90
u/ml
—
8
73
13
150
0.86
0.14
1.8
1.8
—
—
—
0
0
49
463
1.06
0.12
1.4
1.4
—
—
—
0
0
12
136
0.88
0.11
3.5
2.3
132.20
130.15
g/l
—
5
103
5
47
1.06
0.09
1.0
1.2
—
—
—
0
0
6
55
1.09
0.09
1.7
1.1
—
1.04
—
0
23
6
58
1.03
0.08
1.3
1.3
68.50
75.17
umol/l
—
6
58
16
147
1.09
0.07
1.0
1.1
1.65
2.51
u/ml
—
8
72
19
178
1.07
0.05
1.3
1.3
—
—
—
0
0
41
395
1.04
0.05
1.6
1.4
—
—
—
0
0
12
131
0.91
0.05
1.0
1.1
—
—
—
0
0
32
331
0.97
0.03
1.4
1.4
—
—
—
0
0
32
330
0.97
0.03
1.4
1.4
—
—
—
0
0
32
329
0.97
0.02
1.4
1.4
—
—
—
0
0
32
329
0.97
0.02
1.4
1.4
—
—
—
0
0
12
116
1.03
0.00
1.2
1.1
—
—
—
0
0
36
359
1.00
0.00
1.4
1.5
—
—
—
0
0
12
117
1.03
0.00
1.2
1.1
—
73.86
—
0
28
6
61
0.98
-0.00
14.2
12.0
0.63
0.65
mmol/l
—
6
56
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
7
75
0.93
-0.00
1.6
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.9
—
0.56
—
0
9
7
78
0.90
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
1.41
—
0
5
0
9
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
—
—
0
0
7
75
0.93
-0.00
3.6
2.5
107.57
105.97
mmol/l
—
7
75
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
89
1.01
-0.00
1.1
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_LIVER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_LIVER | 1.688 [1.43, 2.0] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.509 |
During the follow-up period (1.1.1998 — 31.12.2019), 253 out of 2095 females with CD2_BENIGN_LIVER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_LIVER | 1.949 [1.56, 2.44] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.054 |
During the follow-up period (1.1.1998 — 31.12.2019), 245 out of 876 males with CD2_BENIGN_LIVER died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_LIVER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.149% | 0.446% |
| 5 | 0.979% | 2.341% |
| 10 | 2.673% | 6.015% |
| 15 | 5.274% | 11.44% |
| 20 | 9.294% | 19.489% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_LIVER – Benign neoplasm: Liver
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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