marasmus: The lack of sufficient energy or protein to meet the body's metabolic demands, as a result of either an inadequate dietary intake of protein, intake of poor quality dietary protein, increased demands due to disease, or increased nutrient losses.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
67 |
4. Check minimum number of eventsNone |
67 |
5. Include endpointsNone |
67 |
6. Filter based on genotype QC (FinnGen only) |
65 |
Control definitions (FinnGen only)
- Control exclude
- E4_MALNUTRITION
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E40-E46
- Name in latin
- Malnutritio gravis ex deficientia energetica (marasmus nutritionalis)
Similar endpoints
↥List of similar endpoints to
Nutritional marasmus
based on the number of shared cases.
Similar with more cases:
- Malnutrition
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 989 | 547 | 434 |
| Only index persons | 714 | 397 | 317 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 63.82 | 66.09 | 60.76 |
| Only index persons | 59.82 | 61.49 | 57.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 65 | 39 | 26 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 55.78 | 51.28 | 62.54 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 67
- Matched controls
- 670
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E41
ICD-10 Finland
Nutritional marasmus
+∞
88.5
64
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.3
10.5
36
121
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
6.1
10.3
23
53
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
25.6
6.9
9
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
9.2
6.5
13
17
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.7
6.5
36
161
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
36
130
4.82
9.41
2.4
1.9
2.83
3.04
mg/l
0.24
31
118
25
84
4.15
6.86
2.8
1.5
1788.35
1127.12
nmol/l
2.65
20
66
44
223
3.83
6.53
19.1
11.7
1.09
1.30
inr
1.40
17
59
21
71
3.85
5.59
2.2
2.0
2.43
2.37
g/l
0.19
21
66
25
97
3.52
5.42
2.3
1.8
483.47
464.24
pmol/l
0.11
19
84
29
129
3.20
4.99
7.1
3.7
0.00
0.00
estimate
-0.00
11
43
17
54
3.88
4.89
9.7
7.6
107.00
103.19
mmol/l
0.82
17
54
43
253
2.95
4.34
13.9
7.0
1.21
1.22
mmol/l
0.23
32
224
14
40
4.15
3.90
6.4
3.2
—
—
—
0
0
8
12
7.40
3.79
5.5
6.3
260.50
195.08
%
—
8
12
34
187
2.66
3.75
2.1
1.9
89.87
103.42
pmol/l
1.00
16
91
11
26
4.85
3.70
20.6
6.0
94.35
94.45
%
0.02
11
26
41
255
2.57
3.42
6.2
3.4
0.00
0.00
estimate
-0.00
12
47
11
29
4.33
3.37
2.1
4.6
96.60
61.08
ml/min/173m2
—
5
13
11
29
4.33
3.37
20.6
5.5
0.73
0.68
%
0.17
11
29
41
257
2.53
3.33
6.2
3.4
0.00
0.00
estimate
-0.00
11
44
8
15
5.89
3.30
5.5
5.6
93.38
91.47
%
—
8
15
46
306
2.61
3.27
16.6
4.5
7.00
6.60
mmol/l
0.20
46
287
40
254
2.43
3.08
7.3
4.8
0.00
0.00
estimate
-0.00
12
47
28
153
2.43
3.00
1.6
1.4
0.45
0.90
u/ml
1.25
11
41
7
13
5.87
2.95
6.0
6.1
3.44
3.62
g/l
—
7
13
31
180
2.34
2.87
7.6
2.6
—
—
—
0
0
10
29
3.87
2.83
22.1
5.5
1.18
1.55
%
—
10
29
32
190
2.31
2.80
6.6
3.7
—
—
—
0
0
22
113
2.41
2.65
3.0
2.0
—
—
—
0
0
6
11
5.87
2.60
35.5
2.4
25.53
25.59
mmol/l
—
6
11
45
315
2.31
2.59
14.3
9.4
4.61
3.82
e9/l
0.87
45
277
30
180
2.21
2.50
3.0
4.2
23.73
35.99
ng/l
0.41
20
124
13
55
2.69
2.29
8.2
7.9
—
—
—
0
0
8
24
3.64
2.26
3.0
4.8
1.70
1.24
%
—
8
24
16
81
2.28
1.95
4.0
2.3
0.80
0.94
e6/l
0.11
11
43
35
240
1.96
1.93
3.3
2.4
—
—
—
0
0
15
77
2.22
1.76
2.9
1.8
—
—
—
0
0
8
31
2.79
1.72
1.5
1.6
—
—
—
0
0
12
57
2.35
1.67
3.3
1.6
—
—
—
0
0
12
57
2.35
1.67
2.5
1.6
—
—
—
0
0
21
129
1.91
1.54
3.1
3.6
2126.14
1035.69
ng/l
0.42
21
114
14
75
2.10
1.48
3.7
2.5
3.33
4.15
e6/l
—
9
38
6
24
2.64
1.33
2.3
1.9
—
—
—
0
0
5
18
2.91
1.31
1.0
1.3
—
—
—
0
0
6
32
1.96
0.84
15.2
3.3
25.58
24.78
mmol/l
—
6
32
7
38
1.94
0.76
1.0
2.3
2.49
4.22
ug/l
—
7
33
5
27
1.92
0.70
4.4
2.8
24.22
24.31
mmol/l
—
5
27
56
599
0.60
0.67
44.8
18.2
123.25
134.86
g/l
6.10
56
588
47
414
1.45
0.65
5.2
3.9
14.51
14.83
pmol/l
0.32
42
386
0
19
0.00
0.61
0.0
2.1
—
—
—
0
0
10
67
1.58
0.53
3.6
2.5
—
—
—
0
0
34
385
0.76
0.45
2.9
3.4
—
—
—
0
0
56
528
1.37
0.35
28.1
12.4
23.67
20.75
mg/l
0.45
48
405
56
530
1.34
0.32
40.7
14.2
3.96
3.95
mmol/l
0.09
56
516
56
530
1.34
0.32
40.8
14.2
138.07
139.69
mmol/l
3.39
56
516
10
128
0.74
0.30
2.2
1.7
—
—
—
0
0
8
63
1.31
0.29
3.3
2.3
—
—
—
0
0
9
76
1.21
0.26
2.1
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
46
448
1.09
0.06
23.0
12.0
89.68
83.58
ml/min/173m2
0.87
39
348
12
125
0.95
0.00
2.9
5.1
2.02
2.05
ug/l
0.01
12
111
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
7.70
—
0
6
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
6.96
—
0
5
0
5
0.00
-0.00
0.0
4.0
—
0.12
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
262.00
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.3
—
180.33
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint E4_MARASMUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_MARASMUS | 5.254 [2.49, 11.07] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.322 |
During the follow-up period (1.1.1998 — 31.12.2019), 120 out of 307 females with E4_MARASMUS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_MARASMUS | 6.144 [2.76, 13.69] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.122 |
During the follow-up period (1.1.1998 — 31.12.2019), 90 out of 242 males with E4_MARASMUS died.
Mortality risk
Mortality risk for people of age
years, who have E4_MARASMUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.561% | 1.389% |
| 5 | 2.995% | 8.042% |
| 10 | 7.721% | 19.488% |
| 15 | 14.526% | 35.354% |
| 20 | 23.997% | 52.914% |
Relationships between endpoints
↥Index endpoint: E4_MARASMUS – Nutritional marasmus
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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