marasmus: The lack of sufficient energy or protein to meet the body's metabolic demands, as a result of either an inadequate dietary intake of protein, intake of poor quality dietary protein, increased demands due to disease, or increased nutrient losses.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
57 |
4. Check minimum number of eventsNone |
57 |
5. Include endpointsNone |
57 |
6. Filter based on genotype QC (FinnGen only) |
57 |
Control definitions (FinnGen only)
- Control exclude
- E4_MALNUTRITION
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E40-E46
- Name in latin
- Malnutritio gravis ex deficientia energetica (marasmus nutritionalis)
Similar endpoints
↥List of similar endpoints to
Nutritional marasmus
based on the number of shared cases.
Similar with more cases:
- Malnutrition
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 989 | 547 | 434 |
| Only index persons | 714 | 397 | 317 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 63.82 | 66.09 | 60.76 |
| Only index persons | 59.82 | 61.49 | 57.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 57 | 31 | 26 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 51.41 | 43.47 | 60.88 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
No data available
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
26
105
3.71
5.47
6.9
3.6
0.0
0.0
estimate
—
9
36
17
58
3.75
4.47
2.2
2.0
2.5
2.4
g/l
0.61
17
53
8
11
8.24
4.01
5.5
6.7
260.5
192.5
%
—
8
11
12
37
3.84
3.58
6.6
3.1
—
—
—
0
0
8
14
6.45
3.48
5.5
5.9
93.4
91.6
%
—
8
14
34
200
2.73
3.35
14.5
7.1
1.2
1.2
mmol/l
0.20
25
175
7
12
6.47
3.12
6.0
6.5
3.4
3.7
g/l
—
7
12
38
244
2.67
3.03
17.7
4.7
7.3
6.6
mmol/l
0.32
38
228
9
22
4.65
3.03
18.8
6.7
1.2
1.5
%
—
9
22
27
148
2.57
2.98
2.3
1.8
90.1
100.0
pmol/l
0.66
14
72
34
212
2.50
2.81
6.5
3.4
0.0
0.0
estimate
—
9
37
34
214
2.46
2.73
6.5
3.4
0.0
0.0
estimate
—
9
37
27
154
2.43
2.68
6.7
3.7
—
—
—
0
0
12
45
3.11
2.64
8.7
7.7
—
—
—
0
0
33
211
2.34
2.48
7.8
4.9
0.0
0.0
estimate
—
10
40
18
89
2.49
2.39
3.1
2.0
—
—
—
0
0
25
147
2.25
2.24
2.8
4.2
26.2
39.0
ng/l
0.31
14
99
36
254
2.13
1.96
15.1
9.0
3.9
3.8
e9/l
0.11
36
221
7
23
3.32
1.86
1.6
1.8
—
—
—
0
0
29
192
2.04
1.84
5.6
3.5
—
—
—
0
0
23
143
2.02
1.71
9.0
2.6
—
—
—
0
0
6
20
3.23
1.63
3.3
5.4
1.9
1.4
%
—
6
20
21
135
1.88
1.37
1.7
1.4
0.4
0.9
u/ml
—
8
37
10
51
2.17
1.20
7.8
5.4
5.8
5.9
kpa
—
10
51
11
64
1.89
0.94
3.3
2.0
—
—
—
0
0
6
30
2.11
0.90
15.2
3.5
25.6
24.7
mmol/l
—
6
30
6
30
2.11
0.90
1.0
1.9
2.7
4.9
ug/l
—
6
25
8
45
1.90
0.89
4.0
1.7
—
—
—
0
0
8
46
1.86
0.87
2.8
1.7
—
—
—
0
0
15
99
1.70
0.87
3.9
3.8
2691.5
1001.0
ng/l
0.48
15
86
13
90
1.58
0.62
2.2
1.5
22.4
18.7
nmol/l
0.32
13
76
0
19
0.00
0.61
0.0
2.1
—
—
—
0
0
9
64
1.48
0.55
3.9
2.6
—
—
—
0
0
30
347
0.71
0.55
2.8
3.6
—
—
—
0
0
9
120
0.70
0.40
2.2
1.8
—
—
—
0
0
8
61
1.36
0.30
2.3
1.5
—
—
—
0
0
46
436
1.29
0.24
41.5
13.5
138.5
139.7
mmol/l
1.93
46
423
46
436
1.29
0.24
41.4
13.5
4.0
3.9
mmol/l
0.67
46
423
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
46
439
1.25
0.19
28.4
11.9
22.5
21.6
mg/l
0.11
39
331
7
61
1.17
0.18
3.6
2.3
—
—
—
0
0
10
108
0.91
0.03
2.7
5.1
2.1
2.0
ug/l
—
10
95
36
366
0.96
0.00
21.6
11.6
89.4
84.7
ml/min/173m2
0.43
29
283
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
233.4
—
0
5
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
4.0
—
0.1
—
0
5
0
5
0.00
0.00
0.0
1.0
—
1.2
—
0
5
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_MARASMUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_MARASMUS | 5.254 [2.49, 11.07] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.322 |
During the follow-up period (1.1.1998 — 31.12.2019), 120 out of 307 females with E4_MARASMUS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_MARASMUS | 6.144 [2.76, 13.69] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.122 |
During the follow-up period (1.1.1998 — 31.12.2019), 90 out of 242 males with E4_MARASMUS died.
Mortality risk
Mortality risk for people of age
years, who have E4_MARASMUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.561% | 1.389% |
| 5 | 2.995% | 8.042% |
| 10 | 7.721% | 19.488% |
| 15 | 14.526% | 35.354% |
| 20 | 23.997% | 52.914% |
Relationships between endpoints
↥Index endpoint: E4_MARASMUS – Nutritional marasmus
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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