No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
82 |
4. Check minimum number of eventsNone |
82 |
5. Include endpointsNone |
82 |
6. Filter based on genotype QC (FinnGen only) |
77 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Disorder of mineral metabolism, other/unspecified
based on the number of shared cases.
Similar with more cases:
- Disorders of mineral metabolism
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 666 | 410 | 245 |
| Only index persons | 511 | 317 | 194 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 54.70 | 57.04 | 49.92 |
| Only index persons | 49.20 | 51.04 | 46.21 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 77 | 44 | 33 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 45.28 | 42.18 | 49.41 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 82
- Matched controls
- 820
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E83.9
ICD-10 Finland
Disorder of mineral metabolism, unspecified
+∞
58.5
49
*
E83.8
ICD-10 Finland
Other disorders of mineral metabolism
+∞
21.8
20
*
A11CC03
ATC
alfacalcidol; systemic
277.7
21.7
21
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
227.1
18.3
18
*
E83.39
ICD-10 Finland
Other disorder of phosphorus metabolism
+∞
17.3
16
*
V03AG01
ATC
sodium cellulose phosphate; systemic
+∞
13.9
13
*
A12AA04
ATC
calcium carbonate; oral
152.3
12.8
13
*
E83.50
ICD-10 Finland
Hypercalcemia
152.3
12.8
13
*
E83.30
ICD-10 Finland
Acid phosphatase deficiency
+∞
10.6
10
*
E83.3
ICD-10 Finland
Disorders of phosphorus metabolism and phosphatases
+∞
9.6
9
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
5.3
8.2
19
44
E83.51
ICD-10 Finland
Hypocalcemia
+∞
7.4
7
*
27340
ICD-8 Finland
Other and unspecified congenital disorders of metabolism, Other disorders involving metabolism of minerals
+∞
7.4
7
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
43.8
6.9
8
*
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
24.9
6.8
9
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
24.9
6.8
9
*
Z3231
NOMESCO Finland
Registered nurse
3.6
6.8
31
119
AA1AD
NOMESCO Finland
CT of head and brain
3.8
6.6
26
90
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.6
6.4
17
44
EBB15
NOMESCO Finland
Insertion of dental implant abutment
+∞
6.3
6
*
E21.2
ICD-10 Finland
Other hyperparathyroidism
+∞
6.3
6
*
2759X
ICD-9 Finland
Disorders of mineral metabolism, Unspecified disorder of mineral metabolism
+∞
6.3
6
*
E21.1
ICD-10 Finland
Secondary hyperparathyroidism, not elsewhere classified
+∞
6.3
6
*
SPA20
NOMESCO Finland
Selection and insertion of implant abutment
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
62
267
6.42
13.53
18.5
7.6
1.22
1.22
mmol/l
0.02
52
227
20
64
3.81
5.64
1.6
1.5
—
—
—
0
0
45
264
2.56
4.21
3.7
2.3
257.78
99.16
ug/l
0.63
40
241
18
65
3.27
4.18
1.8
1.6
—
—
—
0
0
7
7
10.78
4.09
1.3
1.0
—
—
—
0
0
7
7
10.78
4.09
1.3
1.0
—
—
—
0
0
22
93
2.87
3.90
1.8
1.9
—
—
—
0
0
36
198
2.46
3.77
4.4
2.5
—
—
—
0
0
10
23
4.80
3.44
9.2
2.0
0.58
0.81
%
—
10
23
14
49
3.24
3.38
3.1
2.4
—
—
—
0
0
40
240
2.30
3.36
8.3
4.5
34.67
36.41
g/l
1.17
40
224
30
159
2.40
3.34
4.6
2.3
0.71
0.37
e6/l
0.39
25
118
10
24
4.59
3.32
9.3
2.0
1.59
1.54
%
—
10
24
15
57
3.00
3.17
16.8
8.7
100.53
103.72
mmol/l
0.94
15
57
14
52
3.04
3.07
2.7
2.2
394.43
390.56
nmol/l
0.03
14
45
41
263
2.12
2.79
9.8
11.3
1.21
1.19
inr
0.04
12
72
47
320
2.10
2.71
7.0
3.9
0.00
0.00
estimate
—
9
56
47
321
2.09
2.68
5.5
3.0
0.00
0.00
estimate
-0.00
11
61
7
15
4.99
2.66
4.3
1.9
27.80
27.08
mmol/l
—
7
15
5
7
7.51
2.58
5.4
2.9
—
—
—
0
0
47
327
2.02
2.48
5.5
3.0
0.00
0.00
estimate
—
10
55
34
211
2.04
2.46
3.7
3.5
61.73
26.91
ng/l
0.44
26
129
6
13
4.89
2.31
13.2
1.0
0.00
0.00
g/l
—
6
13
51
376
1.94
2.17
12.0
9.2
4.27
3.93
e9/l
0.52
43
337
37
248
1.90
2.08
6.0
3.1
—
—
—
0
0
5
11
4.76
1.97
4.0
4.7
55.60
58.09
%
—
5
11
18
96
2.12
1.89
4.3
1.9
1.12
1.17
e6/l
0.04
13
58
16
83
2.15
1.80
3.8
2.0
4.94
3.13
e6/l
—
10
45
6
18
3.51
1.78
13.2
1.1
—
—
—
0
0
5
13
4.02
1.74
1.2
1.4
—
—
—
0
0
25
155
1.88
1.74
4.6
3.0
32.99
5.62
mg/mmol
0.48
18
97
8
31
2.75
1.71
2.1
1.2
—
—
—
0
0
39
280
1.75
1.67
2.4
2.8
—
—
—
0
0
27
175
1.81
1.62
6.8
3.4
0.00
0.00
estimate
—
10
55
9
44
2.17
1.31
3.8
1.7
—
—
—
0
0
74
669
2.09
1.31
28.6
13.4
139.41
139.88
mmol/l
0.67
74
648
8
41
2.05
1.12
1.3
1.8
23.02
62.87
u/ml
—
8
41
7
32
2.30
1.11
1.3
1.8
—
—
—
0
0
22
151
1.62
1.05
1.3
1.2
0.48
0.84
u/ml
—
6
33
21
143
1.63
1.03
3.1
3.1
3933.88
1019.79
ng/l
0.57
16
118
73
669
1.83
1.01
30.0
13.5
3.90
3.94
mmol/l
0.40
73
647
21
144
1.62
1.00
2.6
2.5
—
—
—
0
0
0
31
0.00
0.98
0.0
1.6
—
254.64
—
0
16
8
46
1.82
0.85
2.0
2.0
—
—
—
0
0
72
660
1.75
0.85
22.5
12.2
24.22
24.26
mg/l
0.00
58
493
68
620
1.57
0.75
20.5
10.5
80.24
85.18
ml/min/173m2
0.75
63
495
16
113
1.52
0.67
2.3
1.5
1572.00
1155.05
nmol/l
—
10
89
0
22
0.00
0.60
0.0
1.3
—
—
—
0
0
8
54
1.53
0.59
2.4
2.2
—
—
—
0
0
17
127
1.43
0.55
1.4
1.3
9.20
25.93
iu/ml
—
5
41
0
15
0.00
0.41
0.0
1.3
—
1.67
—
0
6
0
15
0.00
0.41
0.0
1.1
—
6.43
—
0
7
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
0
17
0.00
0.41
0.0
1.6
—
—
—
0
0
26
222
1.25
0.35
2.5
1.8
100.75
93.25
pmol/l
0.17
11
114
11
83
1.38
0.34
9.6
6.5
—
—
—
0
0
14
113
1.29
0.29
1.5
1.4
—
—
—
0
0
12
95
1.31
0.28
3.1
2.0
—
—
—
0
0
15
123
1.27
0.28
1.7
1.6
—
—
—
0
0
15
123
1.27
0.28
1.3
1.3
1.64
9.30
u/ml
—
5
40
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
12
106
1.15
0.10
3.8
2.1
—
—
—
0
0
65
634
1.12
0.10
4.3
4.1
5.83
5.78
mmol/l
0.11
58
581
5
45
1.12
0.10
3.2
1.2
—
—
—
0
0
74
743
0.96
0.07
33.8
17.7
133.18
137.22
g/l
1.50
74
730
64
650
0.93
0.04
4.7
4.3
3.05
2.83
mmol/l
1.33
59
599
46
465
0.98
0.00
3.9
3.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
13.21
—
0
8
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
13.43
—
0
7
0
5
0.00
-0.00
0.0
1.8
—
6.04
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
0.31
—
0
5
0
5
0.00
-0.00
0.0
3.8
—
55.40
—
0
5
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
101.00
—
0
5
6
65
0.92
-0.00
1.2
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
64
640
1.00
-0.00
4.1
4.0
4.81
4.79
mmol/l
0.06
59
590
0
6
0.00
-0.00
0.0
1.2
—
3.93
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
100.20
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_MINERAL_METNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_MINERAL_METNAS | 2.427 [1.76, 3.35] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.434 |
During the follow-up period (1.1.1998 — 31.12.2019), 106 out of 288 females with E4_MINERAL_METNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_MINERAL_METNAS | 2.509 [1.54, 4.09] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.018 |
During the follow-up period (1.1.1998 — 31.12.2019), 56 out of 165 males with E4_MINERAL_METNAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_MINERAL_METNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.324% | 0.54% |
| 5 | 1.49% | 3.009% |
| 10 | 3.687% | 7.367% |
| 15 | 6.926% | 14.128% |
| 20 | 11.9% | 23.356% |
Relationships between endpoints
↥Index endpoint: E4_MINERAL_METNAS – Disorder of mineral metabolism, other/unspecified
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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