No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
82 |
4. Check minimum number of eventsNone |
82 |
5. Include endpointsNone |
82 |
6. Filter based on genotype QC (FinnGen only) |
82 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Disorder of mineral metabolism, other/unspecified
based on the number of shared cases.
Similar with more cases:
- Disorders of mineral metabolism
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 666 | 410 | 245 |
| Only index persons | 511 | 317 | 194 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 54.70 | 57.04 | 49.92 |
| Only index persons | 49.20 | 51.04 | 46.21 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 82 | 48 | 34 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | 45.48 | 42.75 | 49.33 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 76
- Matched controls
- 758
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E83.9
ICD-10 Finland
Disorder of mineral metabolism, unspecified
+∞
52.2
44
*
E83.8
ICD-10 Finland
Other disorders of mineral metabolism
+∞
20.8
19
*
A11CC03
ATC
alfacalcidol; systemic
83.0
17.7
19
*
E83.39
ICD-10 Finland
Other disorder of phosphorus metabolism
+∞
16.2
15
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
71.8
15.5
17
*
V03AG01
ATC
sodium cellulose phosphate; systemic
+∞
12.9
12
*
E83.30
ICD-10 Finland
Acid phosphatase deficiency
+∞
10.7
10
*
E83.50
ICD-10 Finland
Hypercalcemia
113.6
9.7
10
*
E83.3
ICD-10 Finland
Disorders of phosphorus metabolism and phosphatases
+∞
8.5
8
*
A12AA04
ATC
calcium carbonate; oral
50.4
7.9
9
*
E87.6
ICD-10 Finland
Hypokalaemia
+∞
7.4
7
*
27340
ICD-8 Finland
Other and unspecified congenital disorders of metabolism, Other disorders involving metabolism of minerals
+∞
7.4
7
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
+∞
7.4
7
*
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
25.2
6.8
9
*
E83.51
ICD-10 Finland
Hypocalcemia
+∞
6.3
6
*
2759X
ICD-9 Finland
Disorders of mineral metabolism, Unspecified disorder of mineral metabolism
+∞
6.3
6
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
4.9
6.3
21
55
Mortality – FinRegistry
↥Association
Association between endpoint E4_MINERAL_METNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_MINERAL_METNAS | 2.427 [1.76, 3.35] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.434 |
During the follow-up period (1.1.1998 — 31.12.2019), 106 out of 288 females with E4_MINERAL_METNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_MINERAL_METNAS | 2.509 [1.54, 4.09] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.018 |
During the follow-up period (1.1.1998 — 31.12.2019), 56 out of 165 males with E4_MINERAL_METNAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_MINERAL_METNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.324% | 0.54% |
| 5 | 1.49% | 3.009% |
| 10 | 3.687% | 7.367% |
| 15 | 6.926% | 14.128% |
| 20 | 11.9% | 23.356% |
Relationships between endpoints
↥Index endpoint: E4_MINERAL_METNAS – Disorder of mineral metabolism, other/unspecified
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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