Disorder of mineral metabolism, other/unspecified

E4_MINERAL_METNAS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E83.8, E83.9 Hospital discharge: ICD-9 — 275[8-9] Hospital discharge: ICD-8 — 27340 Cause of death: ICD-10 — E83.8, E83.9 Cause of death: ICD-9 — 275[8-9] Cause of death: ICD-8 — 27340 2 out of 7 registries used, show all original rules.	82
4. Check minimum number of events None	82
5. Include endpoints None	82
6. Filter based on genotype QC (FinnGen only)	82

Control definitions (FinnGen only)

Control exclude: E4_METABOLIA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	E4_MINERAL_METNAS
CONTROL_EXCLUDE	E4_METABOLIA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E83[8-9]
HD_ICD_9	275[8-9]
HD_ICD_8	27340
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E83[8-9]
COD_ICD_9	275[8-9]
COD_ICD_8	27340
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Disorder of mineral metabolism, other/unspecified based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	666	410	245
Only index persons	511	317	194
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	54.70	57.04	49.92
Only index persons	49.20	51.04	46.21

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	82	48	34
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	45.48	42.75	49.33

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
76: Matched controls
758

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

E83.9

ICD-10 Finland

Disorder of mineral metabolism, unspecified

+∞

52.2

E83.8

ICD-10 Finland

Other disorders of mineral metabolism

+∞

20.8

A11CC03

ATC

alfacalcidol; systemic

83.0

17.7

E83.39

ICD-10 Finland

Other disorder of phosphorus metabolism

+∞

16.2

123

Kela drug reimbursment

Chronic disorders of vitamin D metabolism

71.8

15.5

V03AG01

ATC

sodium cellulose phosphate; systemic

+∞

12.9

E83.30

ICD-10 Finland

Acid phosphatase deficiency

+∞

10.7

E83.50

ICD-10 Finland

Hypercalcemia

113.6

9.7

E83.3

ICD-10 Finland

Disorders of phosphorus metabolism and phosphatases

+∞

8.5

A12AA04

ATC

calcium carbonate; oral

50.4

7.9

E87.6

ICD-10 Finland

Hypokalaemia

+∞

7.4

E87.1

ICD-10 Finland

Hypo-osmolality and hyponatraemia

+∞

7.4

27340

ICD-8 Finland

Other and unspecified congenital disorders of metabolism, Other disorders involving metabolism of minerals

+∞

7.4

E21.09

ICD-10 Finland

Other primary hyperparathyroidism

25.2

6.8

2759X

ICD-9 Finland

Disorders of mineral metabolism, Unspecified disorder of mineral metabolism

+∞

6.3

E83.51

ICD-10 Finland

Hypocalcemia

+∞

6.3

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

4.9

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

271

6.28

13.18

18.6

7.6

1.2

mmol/l

0.00

230

(3020779) Urea [Moles/volume] in Serum or Plasma

6.04

9.37

7.8

6.3

8.8

8.1

mmol/l

0.21

(3012544) pH of Venous blood

5.73

8.88

8.2

3.0

—

(3018418) pH of Serum or Plasma

178

3.98

8.80

16.4

2.7

7.4

—

(3026782) Osmolality of Urine

4.08

7.91

2.7

2.4

510.2

592.5

mosm/kgh2o

0.68

(3000991) Gas panel - Venous blood

4.85

6.43

14.3

9.7

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

19.93

6.42

5.0

1.2

—

(3032333) Phosphate [Mass or Moles] in 24 hour Urine

+∞

6.32

1.0

0.0

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.81

5.64

1.6

1.5

—

(3023368) Bacteria identified in Blood by Culture

147

2.78

4.51

4.5

4.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.27

4.18

1.8

1.6

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

10.78

4.09

1.3

1.0

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

10.78

4.09

1.3

1.0

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

268

2.51

4.02

3.7

2.4

257.8

100.6

ug/l

0.62

245

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.90

3.98

1.8

1.9

—

(3026008) Bacteria identified in Urine by Culture

179

2.54

3.94

3.8

2.6

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

4.42

3.82

9.3

1.9

1.6

1.5

—

(3015736) pH of Urine

249

2.41

3.71

4.8

3.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

200

2.43

3.67

4.7

2.5

—

(1616796) Gas panel - Central venous blood

6.69

3.59

5.1

2.0

—

(4034850)

6.69

3.59

11.5

22.9

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

239

2.32

3.40

8.3

4.6

34.7

36.4

g/l

1.15

223

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

3.24

3.38

3.1

2.4

—

(3044640) Blood type and Crossmatch panel - Blood

191

2.33

3.32

2.3

2.4

—

(3025941) Bacteria identified in Stool by Culture

3.58

3.19

2.0

1.3

—

(3000330) Specific gravity of Urine by Test strip

3.79

3.16

1.8

3.4

—

(3030467) Casts [#/volume] in Urine by Automated count

163

2.33

3.13

4.6

2.3

0.7

0.4

e6/l

0.40

120

(3036481) Cortisol [Moles/volume] in Serum or Plasma

3.04

3.07

2.7

2.3

394.4

382.5

nmol/l

0.11

(36304419) Bacteria [Presence] in Urine

158

2.29

2.99

4.2

2.2

—

(42870588) Differential panel, method unspecified - Blood

209

2.18

2.88

6.8

6.2

—

(3042936) Bacteria identified in Isolate by Culture

2.49

2.84

2.0

2.2

—

(3021901) Oxygen saturation in Capillary blood

6.37

2.75

3.3

2.3

—

(3035350) Ketones [Presence] in Urine by Test strip

320

2.10

2.71

5.5

3.2

0.0

estimate

—

(3021601) Nitrite [Presence] in Urine by Test strip

320

2.10

2.71

7.0

4.1

0.0

estimate

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

149

2.21

2.67

4.1

3.5

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

7.51

2.58

5.4

2.9

—

(3002582) Erythrocytes [#/volume] in Urine

175

2.13

2.57

4.4

2.3

25.2

61.5

e6/l

0.65

133

(3018095) Leukocytes [#/volume] in Urine

217

2.07

2.56

5.0

2.6

209.0

33.9

e6/l

0.60

147

(3009343) pH of Capillary blood

3.02

2.48

7.3

2.7

7.4

—

(3009261) Glucose [Presence] in Urine by Test strip

327

2.02

2.48

5.5

3.2

0.0

estimate

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

5.30

2.45

13.2

1.0

0.0

g/l

—

(3013290) Carbon dioxide [Partial pressure] in Blood

5.30

2.45

4.7

1.4

5.1

4.9

kpa

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

5.30

2.45

2.0

1.3

—

(3027315) Oxygen [Partial pressure] in Blood

5.30

2.45

4.7

1.4

9.1

9.9

kpa

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

2.94

2.38

7.2

2.6

5.6

5.2

kpa

0.49

(3032080) INR in Blood by Coagulation assay

231

2.00

2.36

6.7

7.0

1.1

1.2

inr

0.34

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

214

2.01

2.35

3.7

3.6

61.7

26.6

ng/l

0.44

132

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

4.89

2.31

2.0

1.3

—

(3023511) Choriogonadotropin [Units/volume] in Urine

5.24

2.10

1.0

1.3

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

249

1.89

2.05

6.0

3.3

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

382

1.89

2.01

12.0

9.3

4.3

3.9

e9/l

0.54

344

(3024891) Influenza virus A+B Ag [Presence] in Specimen

3.96

1.97

1.3

1.1

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

4.76

1.97

2.6

3.2

4.6

3.9

e9/l

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

4.76

1.97

4.0

4.7

55.6

58.1

—

(3012516) Albumin [Mass/volume] in Urine

141

1.99

1.96

4.1

2.8

129.4

499.1

mg/l

0.37

(3020891) Body temperature

3.38

1.92

13.3

2.9

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.72

1.87

13.2

1.1

—

(3001604) Monocytes [#/volume] in Blood

329

1.82

1.87

7.4

6.0

0.6

e9/l

0.53

289

(3004588) Protein electrophoresis panel - Serum or Plasma

2.76

1.86

8.8

1.2

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

4.36

1.85

1.2

1.4

—

(3006315) Basophils [#/volume] in Blood

330

1.81

1.84

7.4

6.1

0.0

e9/l

0.52

291

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

275

1.80

1.81

3.7

4.5

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

2.15

1.80

3.7

2.1

4.9

3.2

e6/l

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

2.07

1.79

4.3

1.9

1.1

1.2

e6/l

0.04

(3020682) Albumin/Creatinine [Ratio] in Urine

154

1.90

1.77

4.6

3.3

33.0

5.7

mg/mmol

0.48

(40760888) Immunoglobulin light chains.free panel - Serum

4.02

1.74

7.4

1.1

—

(3052851) Hemolysis interference index of Serum or Plasma

3.32

1.69

2.2

3.2

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.66

1.64

2.1

1.2

—

(3029937) Albumin [Presence] in Urine by Test strip

176

1.80

1.59

6.8

3.7

0.0

estimate

—

(3019198) Lymphocytes [#/volume] in Blood

340

1.72

1.58

7.5

6.1

1.9

1.8

e9/l

0.42

304

(1761482) Bacteria [#/volume] in Urine by Culture

3.48

1.54

3.0

4.3

—

(3013115) Eosinophils [#/volume] in Blood

342

1.70

1.53

7.6

6.2

0.2

e9/l

0.84

307

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.34

1.42

3.8

1.8

—

(3031040) Bacteria [#/volume] in Urine by Automated count

419

1.66

1.36

6.8

3.6

—

21.2

—

(40761536) Microorganisms panel - Urine sediment

2.15

1.34

10.2

3.1

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

669

2.09

1.31

28.6

13.7

139.4

139.9

mmol/l

0.64

648

(3041096) Erythrocytes [Presence] in Urine by Automated

177

1.69

1.29

5.8

2.7

—

(3037467) Urinalysis macro (dipstick) panel - Urine

453

1.65

1.28

5.6

3.6

—

(3021589) Normoblasts [#/volume] in Blood

289

1.59

1.21

12.9

7.8

0.0

e9/l

0.50

238

(3045414) Leukocytes [Presence] in Urine

2.41

1.21

1.3

1.8

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

2.11

1.15

1.3

2.3

23.0

64.7

u/ml

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.37

1.13

1.3

1.9

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.47

1.10

1.2

1.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.87

1.10

1.8

1.5

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

141

1.66

1.09

2.6

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

150

1.64

1.08

1.3

1.2

0.5

0.8

u/ml

—

(40758558) Short blood count panel - Blood

168

1.61

1.06

11.0

7.7

—

(40761535) Cells panel - Urine sediment

1.97

1.01

4.0

4.1

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

669

1.83

1.01

30.0

13.8

3.9

mmol/l

0.38

647

(3013512) EKG study

170

1.58

1.01

3.2

3.1

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.97

0.0

1.6

—

240.4

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

148

1.56

0.89

3.1

3.3

3933.9

1027.3

ng/l

0.57

123

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.86

0.87

2.0

2.1

—

(40768797) Stomach Pathology biopsy report

1.75

0.87

1.2

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

659

1.76

0.87

22.5

12.4

23.8

24.3

mg/l

0.05

493

(1002224) Polysomnography panel

2.01

0.86

1.0

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.25

0.77

5.2

33.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

153

1.50

0.77

5.7

4.8

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

620

1.57

0.75

20.5

10.7

79.8

85.2

ml/min/173m2

0.83

492

(3027945) Reticulocytes/100 erythrocytes in Blood

1.73

0.72

2.2

2.9

2.2

1.8

—

(3022313) Gas panel - Capillary blood

1.91

0.69

7.4

2.9

—

(3019309) Folate [Moles/volume] in Red Blood Cells

114

1.50

0.65

2.3

1.5

1572.0

1197.7

nmol/l

—

(36660697) Celiac disease serology panel - Serum

1.66

0.63

1.3

1.1

—

(3000494) Fungus identified in Specimen by Culture

1.56

0.61

1.5

1.7

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.61

0.0

1.3

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.56

0.60

2.4

2.3

—

(3019225) pH of Specimen

1.53

0.59

11.6

4.4

—

(3022145) Colonoscopy Study observation

1.61

0.58

2.1

1.4

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

128

1.41

0.53

1.4

1.3

9.2

26.4

iu/ml

—

(40761511) CBC panel - Blood by Automated count

692

1.50

0.48

20.3

10.8

—

(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.41

0.0

1.3

—

1.7

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.41

0.0

1.1

—

6.4

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.41

0.0

4.9

—

22.3

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

1.3

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.41

0.0

1.6

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.41

0.0

1.6

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.46

0.40

2.6

2.0

—

(3044889) 12 lead EKG panel

435

1.25

0.39

3.9

3.4

—

(3022621) pH of Urine by Test strip

1.43

0.36

2.0

1.9

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.36

0.32

9.6

7.0

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

227

1.21

0.28

2.5

1.8

100.7

93.0

pmol/l

0.18

118

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

123

1.27

0.28

1.3

1.6

8.8

u/ml

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

115

1.26

0.25

1.5

1.4

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.28

0.24

3.1

1.9

—

(3019060) Gas panel - Arterial blood

1.34

0.23

3.8

16.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

126

1.23

0.23

1.7

1.6

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

103

0.75

0.22

2.5

1.5

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(4306422)

0.00

0.21

0.0

1.3

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.21

0.0

1.1

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.21

0.0

1.0

—

(4268621)

0.00

0.21

0.0

1.9

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.21

0.0

1.2

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.4

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.4

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.1

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.21

0.0

1.2

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.20

0.0

1.3

—

(4035726)

1.20

0.18

1.4

1.3

—

(3000492) Spirometry study

1.14

0.18

2.1

1.5

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.14

0.16

2.7

1.7

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.15

0.10

3.2

1.3

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

635

1.11

0.09

4.3

4.0

5.8

mmol/l

0.12

582

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.82

0.08

1.4

1.5

—

(4010399)

0.82

0.08

1.4

1.5

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

108

1.13

0.08

3.8

2.1

—

(3010813) Leukocytes [#/volume] in Blood

744

0.94

0.07

33.5

18.0

6.9

6.4

e9/l

1.34

722

(3026361) Erythrocytes [#/volume] in Blood

743

0.96

0.07

33.5

18.0

4.4

4.6

e12/l

1.41

721

(3035941) MCH [Entitic mass]

743

0.96

0.07

33.3

17.9

30.3

30.2

0.08

730

(3000963) Hemoglobin [Mass/volume] in Blood

743

0.96

0.07

33.8

18.0

133.2

137.2

g/l

1.48

730

(3024731) MCV [Entitic volume]

743

0.96

0.07

33.3

17.9

90.9

90.6

0.20

730

(3007461) Platelets [#/volume] in Blood

742

0.97

0.07

33.7

18.0

269.3

251.2

e9/l

1.40

723

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

652

0.92

0.06

4.7

4.3

3.1

2.8

mmol/l

1.35

600

(46235355) HIV 1 and 2 tests - Meaningful Use set

151

1.07

0.03

2.8

2.0

—

(3003694) ABO and Rh group [Type] in Blood

181

1.06

0.03

1.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

128

0.93

0.03

2.2

1.6

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

466

0.97

0.00

3.9

3.1

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

642

0.99

0.00

4.1

4.0

4.8

mmol/l

0.07

591

(3009542) Hematocrit [Volume Fraction] of Blood

627

1.02

0.00

22.7

12.2

40.6

40.3

0.17

471

(1761868) Lipid panel - Serum or Plasma

234

0.98

0.00

2.6

2.4

—

(40768804) Tissue Pathology biopsy report

264

0.98

0.00

2.0

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.6

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.4

—

(4281824)

0.00

0.0

1.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

2.0

—

64.3

—

(3017704) Immunofixation for Urine

0.00

0.0

1.0

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.4

—

(3020491) Glucose [Moles/volume] in Blood

0.00

0.0

1.4

—

7.2

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.5

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.90

0.00

2.8

1.6

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

2.0

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.1

—

(3015076) Soybean IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

110.0

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

2.0

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

0.0

2.8

—

21.3

—

(3041423) Sjogrens syndrome-A extractable nuclear 60kD Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3023659) Complement C1 esterase inhibitor.functional/Complement C1 esterase inhibitor.total in Serum or Plasma

0.00

0.0

1.0

—

100.2

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.0

1.6

—

3.1

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

3.8

—

55.4

—

(3036669) Protein S actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.2

—

101.0

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

36.2

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

2.2

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.0

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

0.3

—

(3027456) Digoxin [Moles/volume] in Serum or Plasma

0.00

0.0

3.0

—

0.9

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

2.2

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

2.7

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

2.2

—

0.8

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

0.0

2.2

—

15.4

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

1.0

—

13.4

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.0

1.1

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

2.7

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.89

0.00

1.2

1.6

—

(3047826) Mullerian inhibiting substance [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

3.9

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.1

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(3002256) Pathology report gross observation

0.87

0.00

1.3

1.2

—

(3041067) Sjogrens syndrome-A extractable nuclear 52kD Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_MINERAL_METNAS and mortality.

Females

Parameter	HR [95% CI]	p-value
E4_MINERAL_METNAS	2.427 [1.76, 3.35]	< 0.001
Birth year	0.997 [0.99, 1.01]	0.434

During the follow-up period (1.1.1998 — 31.12.2019), 106 out of 288 females with E4_MINERAL_METNAS died.

Males

Parameter	HR [95% CI]	p-value
E4_MINERAL_METNAS	2.509 [1.54, 4.09]	< 0.001
Birth year	0.989 [0.98, 1.0]	0.018

During the follow-up period (1.1.1998 — 31.12.2019), 56 out of 165 males with E4_MINERAL_METNAS died.

Mortality risk

Mortality risk for people of age

years, who have E4_MINERAL_METNAS.

N-year risk	Females	Males
1	0.324%	0.54%
5	1.49%	3.009%
10	3.687%	7.367%
15	6.926%	14.128%
20	11.9%	23.356%

Relationships between endpoints

↥

Index endpoint: E4_MINERAL_METNAS – Disorder of mineral metabolism, other/unspecified

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Disorder of mineral metabolism, other/unspecified

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints