No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
85 |
4. Check minimum number of eventsNone |
85 |
5. Include endpointsNone |
85 |
6. Filter based on genotype QC (FinnGen only) |
83 |
Control definitions (FinnGen only)
- Control exclude
- M13_ARTHROPATHIES
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M12
- Name in latin
- Hydrarthrosis intermittens
Similar endpoints
↥List of similar endpoints to
Intermittent hydrarthrosis
based on the number of shared cases.
Similar with more cases:
- Polyarthropathies
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 574 | 323 | 250 |
| Only index persons | 546 | 312 | 234 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 42.37 | 44.04 | 40.33 |
| Only index persons | 41.74 | 43.43 | 39.48 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 83 | 48 | 35 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 44.01 | 42.23 | 46.45 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 85
- Matched controls
- 850
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M12.4
ICD-10 Finland
Intermittent hydrarthrosis
+∞
78.8
63
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
61.6
25.6
29
7
M25.4
ICD-10 Finland
Effusion of joint
274.6
21.6
21
*
7193F
ICD-9 Finland
Other and unspecified disorder of joint, Palindromic rheumatism[HYDRARTHROSIS INTERMITTENS, POLVI]
+∞
20.7
19
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
19.5
19.4
30
23
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
241.0
19.4
19
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
+∞
18.4
17
*
M13.9
ICD-10 Finland
Arthritis, unspecified
54.8
18.3
21
5
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
17.3
16
*
A07EC01
ATC
sulfasalazine; oral, rectal
25.7
16.7
23
12
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
29.1
16.6
22
10
L15
ICPC
Knee symptom/complaint
6.7
15.4
33
74
P01BA02
ATC
hydroxychloroquine; oral
44.9
15.1
18
5
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
+∞
15.0
14
*
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
52.2
14.7
17
*
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
37.4
14.6
18
6
M25.5
ICD-10 Finland
Pain in joint
5.8
14.0
37
100
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
+∞
13.9
13
*
L01BA01
ATC
methotrexate; systemic
+∞
12.8
12
*
1220
FHL
Arthroscopy
35.8
12.1
15
5
L04AX03
ATC
methotrexate; systemic
15.9
11.8
19
15
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
20.8
11.8
17
10
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
137.9
11.7
12
*
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
+∞
11.7
11
*
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
13.1
10.4
18
17
WX320
NOMESCO Finland
Spinalanesthesy
4.8
9.0
25
68
L04AA13
ATC
[U] leflunomide
99.5
8.6
9
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
4.1
8.5
32
109
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
+∞
8.5
8
*
M01AH01
ATC
celecoxib; oral
5.0
8.4
21
52
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
37.3
8.3
10
*
M16.1
ICD-10 Finland
Other primary coxarthrosis
24.9
8.2
11
5
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
87.4
7.5
8
*
NG1DA
NOMESCO Finland
X-ray of knees
+∞
7.4
7
*
M19.0
ICD-10 Finland
Primary arthrosis of other joints
33.1
7.3
9
*
L03
ICPC
Low back symptom/complaint
3.5
6.9
32
124
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
43.7
6.9
8
*
L88
ICPC
Rheumatoid/seropositive arthritis
24.8
6.8
9
*
M01AH05
ATC
etoricoxib; oral
3.5
6.7
60
346
M54.5
ICD-10 Finland
Low back pain
3.3
6.6
41
189
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
12.4
6.5
11
10
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
+∞
6.3
6
*
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
+∞
6.3
6
*
1222
FHL
Arthroscopy and synovial surgery
+∞
6.3
6
*
M25.0
ICD-10 Finland
Haemarthrosis
+∞
6.3
6
*
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
+∞
6.3
6
*
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
+∞
6.3
6
*
L04AB01
ATC
etanercept; parenteral
+∞
6.3
6
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
27
76
4.74
9.32
1.3
1.1
33.80
1.28
u/ml
0.88
13
32
26
88
3.82
6.85
1.2
1.2
20.16
15.88
iu/ml
0.29
11
26
9
12
8.23
4.48
4.7
4.0
53.11
60.75
%
—
9
12
66
475
2.74
3.77
7.5
2.9
10.88
10.30
mm/h
0.15
60
427
8
14
6.18
3.43
1.3
1.6
—
—
—
0
0
42
256
2.27
3.36
5.6
3.4
—
—
—
0
0
80
675
4.14
3.35
4.6
4.1
5.70
5.88
mmol/l
0.58
69
625
31
167
2.35
3.30
5.8
3.6
0.00
0.02
estimate
0.49
15
59
15
56
3.04
3.26
1.9
3.1
—
—
—
0
0
48
319
2.16
3.00
5.5
3.4
0.00
0.05
estimate
0.49
15
56
48
319
2.16
3.00
7.3
4.7
0.00
0.00
estimate
-0.00
17
59
47
317
2.08
2.76
5.6
3.4
0.00
0.00
estimate
-0.00
17
60
78
663
3.14
2.73
19.4
13.0
20.34
21.69
mg/l
0.15
67
502
24
125
2.28
2.70
1.9
1.7
429.83
482.58
pmol/l
0.37
18
109
42
274
2.05
2.67
2.9
2.3
—
—
—
0
0
53
380
2.05
2.56
9.6
9.6
3.55
4.17
e9/l
1.56
47
334
7
16
4.66
2.53
2.0
1.6
—
—
—
0
0
52
374
2.01
2.45
4.0
4.0
6.62
6.62
mmol/l
0.00
47
348
5
10
5.23
2.10
1.0
1.5
—
—
—
0
0
78
681
2.76
2.09
4.3
3.7
1.35
1.32
mmol/l
0.15
69
632
5
11
4.75
1.97
1.2
1.5
—
—
—
0
0
5
11
4.75
1.97
1.0
2.0
—
—
—
0
0
24
142
1.96
1.91
1.4
1.2
0.77
0.81
u/ml
—
6
45
64
520
1.93
1.84
4.6
3.9
14.85
14.78
pmol/l
0.07
53
473
36
246
1.80
1.84
2.6
2.1
75.29
75.01
nmol/l
0.02
31
212
18
97
2.09
1.83
1.9
1.7
1311.08
1112.70
nmol/l
0.36
12
73
40
294
1.68
1.52
13.6
12.3
1.07
1.24
inr
1.55
18
84
24
153
1.79
1.50
1.7
1.6
1.20
1.30
mmol/l
0.56
15
119
23
146
1.79
1.46
1.7
1.4
24.43
22.48
nmol/l
0.23
18
120
33
237
1.64
1.34
6.3
3.6
15.03
22.66
ng/l
1.22
21
153
72
632
1.91
1.32
5.2
4.5
1.79
1.95
mu/l
0.78
62
571
25
168
1.69
1.30
3.6
4.6
20.69
20.71
%
0.00
11
86
5
19
2.73
1.23
1.2
1.4
—
—
—
0
0
59
500
1.59
1.13
3.1
2.5
38.72
43.32
u/l
0.48
53
471
7
32
2.29
1.11
6.1
4.0
0.73
0.73
%
—
7
32
7
33
2.22
1.08
6.4
4.0
1.69
1.89
%
—
7
33
18
118
1.67
1.01
1.8
1.4
—
—
—
0
0
7
37
1.97
0.96
1.6
1.7
—
—
—
0
0
31
235
1.50
0.95
2.0
1.9
119.20
95.98
pmol/l
1.74
20
128
18
121
1.62
0.92
3.3
2.6
0.59
0.73
ug/l
—
10
75
13
80
1.74
0.91
2.1
2.5
2.38
2.32
g/l
0.17
13
75
71
642
1.64
0.89
6.4
5.2
39.45
39.41
mmol/mol
0.01
62
597
24
176
1.51
0.85
3.1
3.1
517.85
955.91
ng/l
1.22
16
157
80
752
2.08
0.84
15.9
9.0
27.55
26.82
u/l
0.17
75
730
37
300
1.41
0.78
5.0
6.7
1.22
1.21
mmol/l
0.14
27
254
23
171
1.47
0.76
4.3
3.5
13.65
8.44
mg/mmol
0.30
17
107
12
77
1.65
0.73
1.8
2.6
22.08
23.77
%
0.17
12
62
79
747
1.81
0.67
19.6
14.2
76.19
76.09
umol/l
0.01
79
747
5
29
1.77
0.65
7.6
3.7
25.18
23.99
mmol/l
—
5
29
13
89
1.54
0.62
2.3
2.5
12.34
14.67
umol/l
0.65
13
84
41
349
1.34
0.61
4.2
6.9
9.00
10.40
umol/l
1.22
36
333
0
20
0.00
0.61
0.0
2.3
—
—
—
0
0
0
21
0.00
0.61
0.0
2.6
—
—
—
0
0
0
22
0.00
0.60
0.0
1.5
—
—
—
0
0
6
36
1.72
0.58
1.5
2.2
—
—
—
0
0
6
37
1.67
0.57
2.8
1.2
—
—
—
0
0
6
38
1.62
0.55
1.2
1.0
—
—
—
0
0
10
71
1.46
0.41
8.1
4.9
106.60
103.90
mmol/l
—
10
71
65
607
1.30
0.41
23.7
14.9
15.69
14.77
%
0.49
65
597
70
661
1.33
0.40
18.6
11.8
83.59
83.37
ml/min/173m2
0.03
63
548
27
234
1.23
0.32
3.1
2.9
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
0
13
0.00
0.21
0.0
2.0
—
0.57
—
0
7
10
82
1.25
0.18
2.2
1.9
—
—
—
0
0
8
69
1.18
0.17
2.3
1.8
—
—
—
0
0
15
131
1.18
0.15
2.5
2.2
—
—
—
0
0
47
457
1.06
0.06
3.3
3.1
—
—
—
0
0
11
100
1.11
0.05
1.4
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.1
—
—
—
0
0
6
60
1.00
-0.00
1.5
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
73
0.96
-0.00
6.9
6.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.3
—
—
—
0
0
6
61
0.98
-0.00
1.5
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
0.14
—
0
5
0
8
0.00
-0.00
0.0
2.0
—
13.87
—
0
8
0
9
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
19.12
—
0
5
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.1
—
—
—
0
0
9
91
0.99
-0.00
1.3
1.9
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_INTERHYDRARTHR and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have M13_INTERHYDRARTHR.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: M13_INTERHYDRARTHR – Intermittent hydrarthrosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data