No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
86 |
4. Check minimum number of eventsNone |
86 |
5. Include endpointsNone |
86 |
6. Filter based on genotype QC (FinnGen only) |
86 |
Control definitions (FinnGen only)
- Control exclude
- M13_ARTHROPATHIES
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M12
- Name in latin
- Hydrarthrosis intermittens
Similar endpoints
↥List of similar endpoints to
Intermittent hydrarthrosis
based on the number of shared cases.
Similar with more cases:
- Polyarthropathies
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 574 | 323 | 250 |
| Only index persons | 546 | 312 | 234 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 42.37 | 44.04 | 40.33 |
| Only index persons | 41.74 | 43.43 | 39.48 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 86 | 49 | 37 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 43.94 | 42.36 | 46.04 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 77
- Matched controls
- 770
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M12.4
ICD-10 Finland
Intermittent hydrarthrosis
+∞
71.3
57
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
40.6
21.9
27
10
M17.1
ICD-10 Finland
Other primary gonarthrosis
45.2
20.9
25
8
7193F
ICD-9 Finland
Other and unspecified disorder of joint, Palindromic rheumatism[HYDRARTHROSIS INTERMITTENS, POLVI]
+∞
19.6
18
*
M25.4
ICD-10 Finland
Effusion of joint
+∞
19.6
18
*
M13.9
ICD-10 Finland
Arthritis, unspecified
231.0
18.4
18
*
A07EC01
ATC
sulfasalazine; oral, rectal
47.1
17.8
21
6
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
+∞
15.1
14
*
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
183.4
15.0
15
*
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
38.4
14.7
18
6
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
30.9
14.6
19
8
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
35.7
13.6
17
6
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
+∞
12.9
12
*
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
12.9
12
*
P01BA02
ATC
hydroxychloroquine; oral
33.1
12.6
16
6
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
23.7
12.2
17
9
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
36.6
12.2
15
5
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
140.1
11.8
12
*
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
51.4
11.3
13
*
M25.5
ICD-10 Finland
Pain in joint
6.5
10.8
32
76
L15
ICPC
Knee symptom/complaint
7.3
10.7
28
56
1220
FHL
Arthroscopy
46.6
10.3
12
*
M01AH05
ATC
etoricoxib; oral
4.7
9.4
55
266
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
+∞
8.5
8
*
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
+∞
8.5
8
*
L04AA13
ATC
leflunomide; oral
+∞
8.5
8
*
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
10.9
7.1
13
14
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
44.1
6.9
8
*
L88
ICPC
Rheumatoid/seropositive arthritis
44.1
6.9
8
*
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
44.1
6.9
8
*
N02AX02
ATC
tramadol; systemic, rectal
3.5
6.4
38
166
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
29.3
6.4
8
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
+∞
6.3
6
*
1222
FHL
Arthroscopy and synovial surgery
+∞
6.3
6
*
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
+∞
6.3
6
*
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
+∞
6.3
6
*
M13.1
ICD-10 Finland
Monoarthritis, not elsewhere classified
+∞
6.3
6
*
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
14.1
6.3
10
8
L03
ICPC
Low back symptom/complaint
4.1
6.2
26
85
B01AF01
ATC
rivaroxaban; oral
9.2
6.1
12
15
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
16
5
38.69
13.10
1.7
1.0
—
—
—
0
0
28
82
4.58
9.18
1.3
1.1
31.5
1.3
u/ml
0.88
14
34
27
93
3.77
6.93
1.1
1.2
19.3
15.4
iu/ml
0.28
12
28
67
481
2.78
3.88
7.6
3.0
11.3
10.4
mm/h
0.21
61
433
81
685
4.13
3.34
4.6
4.1
5.7
5.9
mmol/l
0.66
70
637
43
265
2.25
3.33
5.6
3.5
—
—
—
0
0
8
16
5.39
3.13
1.3
1.7
—
—
—
0
0
15
58
2.92
3.07
1.9
3.2
—
—
—
0
0
25
128
2.34
2.94
1.9
1.7
430.4
491.8
pmol/l
0.48
19
112
49
332
2.11
2.86
7.4
4.8
0.0
0.0
estimate
0.00
17
64
49
332
2.11
2.86
5.5
3.5
0.0
0.0
estimate
0.49
15
61
31
176
2.19
2.86
5.8
3.7
0.0
0.0
estimate
0.49
15
64
43
281
2.06
2.73
4.6
3.6
—
—
—
0
0
79
674
3.11
2.72
19.4
13.0
20.2
21.7
mg/l
0.17
68
514
48
330
2.03
2.62
5.6
3.4
0.0
0.0
estimate
0.00
16
65
54
390
2.03
2.54
9.4
9.1
3.5
4.1
e9/l
1.62
48
344
53
383
2.00
2.45
4.0
4.0
6.6
6.6
mmol/l
0.00
48
358
7
18
4.13
2.30
2.0
1.8
—
—
—
0
0
19
99
2.18
2.11
1.9
1.7
1233.8
1133.3
nmol/l
0.16
13
75
5
10
5.23
2.10
1.0
1.5
—
—
—
0
0
79
691
2.76
2.08
4.4
3.7
1.3
1.3
mmol/l
0.19
70
642
37
252
1.82
1.92
2.6
2.1
75.5
74.9
nmol/l
0.05
32
218
5
12
4.35
1.85
1.0
1.8
—
1.1
—
0
5
24
145
1.91
1.79
1.4
1.2
0.8
0.8
u/ml
—
6
46
5
13
4.01
1.74
1.2
1.5
—
—
—
0
0
65
534
1.89
1.74
4.8
3.8
14.9
14.8
pmol/l
0.07
54
486
34
241
1.68
1.47
6.3
3.7
15.0
23.2
ng/l
1.41
22
157
25
168
1.69
1.29
3.6
4.6
20.7
20.6
%
0.02
11
85
23
151
1.71
1.29
1.7
1.4
24.4
22.5
nmol/l
0.24
18
124
73
645
1.87
1.25
5.4
4.4
1.8
2.0
mu/l
0.81
63
586
24
162
1.67
1.22
1.8
1.6
1.2
1.3
mmol/l
0.49
15
128
5
20
2.59
1.16
1.2
1.4
—
—
—
0
0
60
508
1.60
1.16
3.1
2.5
38.6
43.1
u/l
0.49
54
482
7
34
2.15
1.05
6.4
3.8
1.7
1.9
%
—
7
34
18
118
1.66
1.01
1.8
1.4
—
—
—
0
0
81
760
2.13
0.97
15.9
8.9
27.4
26.7
u/l
0.15
76
739
7
37
1.97
0.96
1.6
1.7
—
—
—
0
0
32
245
1.49
0.93
2.0
1.8
119.5
95.3
pmol/l
1.99
21
133
18
121
1.62
0.92
3.3
2.6
0.6
0.7
ug/l
—
10
75
72
651
1.65
0.91
6.4
5.3
39.4
39.5
mmol/mol
0.01
63
608
25
183
1.52
0.90
3.1
3.2
517.9
991.9
ng/l
1.38
16
163
38
305
1.44
0.86
4.9
6.7
1.2
1.2
mmol/l
0.19
28
259
13
85
1.62
0.74
2.1
2.5
2.4
2.3
g/l
0.17
13
79
80
755
1.85
0.67
19.7
14.2
76.7
76.2
umol/l
0.06
80
755
42
356
1.35
0.65
4.1
6.6
8.9
10.4
umol/l
1.40
37
339
0
20
0.00
0.61
0.0
2.2
—
—
—
0
0
0
21
0.00
0.61
0.0
2.6
—
—
—
0
0
0
22
0.00
0.60
0.0
1.5
—
—
—
0
0
6
35
1.77
0.59
1.5
2.3
—
—
—
0
0
12
82
1.54
0.58
1.8
2.6
22.1
23.2
%
0.11
12
66
6
38
1.62
0.55
2.8
1.2
—
—
—
0
0
6
38
1.62
0.55
1.2
1.0
—
—
—
0
0
13
92
1.49
0.54
2.3
2.5
12.3
14.6
umol/l
0.65
13
87
71
669
1.35
0.42
18.3
11.7
83.3
83.2
ml/min/173m2
0.02
64
554
26
226
1.22
0.29
2.5
4.0
2.4
2.4
mmol/l
0.06
20
203
16
134
1.24
0.25
2.4
2.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
0
13
0.00
0.21
0.0
2.0
—
0.6
—
0
7
27
243
1.16
0.20
3.1
3.0
—
—
—
0
0
10
86
1.18
0.11
2.2
1.8
—
—
—
0
0
8
73
1.11
0.08
2.3
1.8
—
—
—
0
0
11
101
1.10
0.04
1.4
1.5
—
—
—
0
0
47
469
1.00
0.00
3.3
3.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
6
62
0.97
0.00
1.5
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
2.8
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
0.1
—
0
5
7
69
1.02
0.00
6.9
7.7
—
—
—
0
0
0
9
0.00
0.00
0.0
2.0
—
13.2
—
0
9
0
5
0.00
0.00
0.0
1.0
—
19.1
—
0
5
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
9
92
0.98
0.00
1.3
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
6
60
1.00
0.00
1.5
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_INTERHYDRARTHR and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have M13_INTERHYDRARTHR.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: M13_INTERHYDRARTHR – Intermittent hydrarthrosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data