Intermittent hydrarthrosis

M13_INTERHYDRARTHR

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M12.4 Hospital discharge: ICD-9 — 7193 Cause of death: ICD-10 — M12.4 Cause of death: ICD-9 — 7193 2 out of 7 registries used, show all original rules.	86
4. Check minimum number of events None	86
5. Include endpoints None	86
6. Filter based on genotype QC (FinnGen only)	86

Control definitions (FinnGen only)

Control exclude: M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M12
Name in latin: Hydrarthrosis intermittens

NAME	M13_INTERHYDRARTHR
CONTROL_EXCLUDE	M13_ARTHROPATHIES
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M124
HD_ICD_9	7193
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M124
COD_ICD_9	7193
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Intermittent hydrarthrosis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	574	323	250
Only index persons	546	312	234
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	42.37	44.04	40.33
Only index persons	41.74	43.43	39.48

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	86	49	37
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	43.94	42.36	46.04

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
77: Matched controls
770

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M12.4

ICD-10 Finland

Intermittent hydrarthrosis

+∞

71.3

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

40.6

21.9

M17.1

ICD-10 Finland

Other primary gonarthrosis

45.2

20.9

7193F

ICD-9 Finland

Other and unspecified disorder of joint, Palindromic rheumatism[HYDRARTHROSIS INTERMITTENS, POLVI]

+∞

19.6

M25.4

ICD-10 Finland

Effusion of joint

+∞

19.6

M13.9

ICD-10 Finland

Arthritis, unspecified

231.0

18.4

A07EC01

ATC

sulfasalazine; oral, rectal

47.1

17.8

M05.8

ICD-10 Finland

Other seropositive rheumatoid arthritis

+∞

15.1

NGF25

NOMESCO Finland

Operation for osteochondritis of knee, arthroscopic

183.4

15.0

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

38.4

14.7

NG1AA

NOMESCO Finland

Knee X-ray examination without contrast

30.9

14.6

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

35.7

13.6

NJ2MA

NOMESCO Finland

Measurement of mechanical axis of lower leg with X-ray

+∞

12.9

NGB20

NOMESCO Finland

Primary total prosthetic replacement of knee joint without patellar part

+∞

12.9

P01BA02

ATC

hydroxychloroquine; oral

33.1

12.6

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

23.7

12.2

M17.0

ICD-10 Finland

Primary gonarthrosis, bilateral

36.6

12.2

L01BA01

ATC

methotrexate; systemic (folic acid analog.)

140.1

11.8

M23.2

ICD-10 Finland

Derangement of meniscus due to old tear or injury

51.4

11.3

M25.5

ICD-10 Finland

Pain in joint

6.5

10.8

L15

ICPC

Knee symptom/complaint

7.3

10.7

1220

FHL

Arthroscopy

46.6

10.3

M01AH05

ATC

etoricoxib; oral

4.7

9.4

266

M06.0

ICD-10 Finland

Seronegative rheumatoid arthritis

+∞

8.5

NGF15

NOMESCO Finland

Total synovectomy of knee, arthroscopic

+∞

8.5

L04AA13

ATC

leflunomide; oral

+∞

8.5

M17

ICD-10 Finland

Gonarthrosis [arthrosis of knee]

10.9

7.1

281

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab

44.1

6.9

L88

ICPC

Rheumatoid/seropositive arthritis

44.1

6.9

313

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)

44.1

6.9

N02AX02

ATC

tramadol; systemic, rectal

3.5

6.4

166

NGA30

NOMESCO Finland

Exploration of knee joint, arthroscopic

29.3

6.4

NH3DA

NOMESCO Finland

Bilateral foot X-ray examination

+∞

6.3

1222

FHL

Arthroscopy and synovial surgery

+∞

6.3

NGB40

NOMESCO Finland

Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis

+∞

6.3

T84.0

ICD-10 Finland

Mechanical complication of internal joint prosthesis

+∞

6.3

M13.1

ICD-10 Finland

Monoarthritis, not elsewhere classified

+∞

6.3

NGD05

NOMESCO Finland

Partial excision of meniscus of knee, arthroscopic

14.1

6.3

L03

ICPC

Low back symptom/complaint

4.1

6.2

B01AF01

ATC

rivaroxaban; oral

9.2

6.1

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

38.69

13.10

1.7

1.0

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

4.58

9.18

1.3

1.1

u/ml

31.5

1.3

0.88

(3025159) Blasts/100 leukocytes in Blood

4.59

6.98

6.4

5.5

0.0

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

3.77

6.93

1.1

1.2

iu/ml

19.3

15.4

0.28

(3002179) Metamyelocytes/100 leukocytes in Blood

4.58

6.66

6.5

5.3

0.2

1.0

—

(3021440) Promyelocytes/100 leukocytes in Blood

4.41

6.63

6.3

5.4

0.0

0.4

—

(3017181) Myelocytes/100 leukocytes in Blood

4.07

6.00

6.3

5.2

0.2

1.4

—

(40761536) Microorganisms panel - Urine sediment

3.53

4.73

5.2

3.3

—

(3042936) Bacteria identified in Isolate by Culture

3.19

4.57

2.0

1.8

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

7.58

4.28

4.7

3.8

53.1

61.7

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

7.58

4.28

4.8

2.6

e9/l

3.6

4.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

158

2.63

4.23

7.7

5.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

202

2.46

3.92

5.6

2.8

—

(3013707) Erythrocyte sedimentation rate by Westergren method

481

2.78

3.88

7.6

3.0

mm/h

11.3

10.4

0.21

433

(3013115) Eosinophils [#/volume] in Blood

330

2.34

3.59

9.0

4.9

e9/l

0.2

0.21

294

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

685

4.13

3.34

4.6

4.1

mmol/l

5.7

5.9

0.66

637

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

265

2.25

3.33

5.6

3.5

—

(3019198) Lymphocytes [#/volume] in Blood

319

2.25

3.32

9.3

4.9

e9/l

1.9

1.8

0.82

287

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

5.39

3.13

1.3

1.7

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.92

3.07

1.9

3.2

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

128

2.34

2.94

1.9

1.7

pmol/l

430.4

491.8

0.48

112

(46235355) HIV 1 and 2 tests - Meaningful Use set

114

2.39

2.90

1.6

2.0

—

(3021601) Nitrite [Presence] in Urine by Test strip

332

2.11

2.86

7.4

4.8

estimate

0.0

0.00

(3009261) Glucose [Presence] in Urine by Test strip

332

2.11

2.86

5.5

3.5

estimate

0.0

0.49

(3029937) Albumin [Presence] in Urine by Test strip

176

2.19

2.86

5.8

3.7

estimate

0.0

0.49

(3013512) EKG study

170

2.17

2.76

5.6

3.7

—

(3037467) Urinalysis macro (dipstick) panel - Urine

464

2.20

2.73

6.0

3.7

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

281

2.06

2.73

4.6

3.6

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

674

3.11

2.72

19.4

13.0

mg/l

20.2

21.7

0.17

514

(42870588) Differential panel, method unspecified - Blood

196

2.11

2.69

9.0

4.2

—

(3015736) pH of Urine

256

2.05

2.67

4.6

3.2

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

3.30

2.62

1.1

1.3

—

(3035350) Ketones [Presence] in Urine by Test strip

330

2.03

2.62

5.6

3.4

estimate

0.0

0.00

(3013650) Neutrophils [#/volume] in Blood by Automated count

390

2.03

2.54

9.4

9.1

e9/l

3.5

4.1

1.62

344

(3008898) HLA-B27 [Presence]

4.66

2.53

1.1

—

(3002256) Pathology report gross observation

2.47

2.51

1.6

1.3

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

2.58

2.48

1.3

1.7

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

383

2.00

2.45

4.0

mmol/l

6.6

0.00

358

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

4.13

2.30

2.0

1.8

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.32

2.13

1.8

—

(3019309) Folate [Moles/volume] in Red Blood Cells

2.18

2.11

1.9

1.7

nmol/l

1233.8

1133.3

0.16

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

5.23

2.10

1.0

1.5

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

691

2.76

2.08

4.4

3.7

mmol/l

1.3

0.19

642

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.92

2.00

3.0

2.4

—

(3026008) Bacteria identified in Urine by Culture

191

1.88

1.92

2.6

2.8

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

252

1.82

1.92

2.6

2.1

nmol/l

75.5

74.9

0.05

218

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

4.35

1.85

1.0

1.8

—

1.1

—

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

4.35

1.85

1.0

1.8

—

1.7

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

145

1.91

1.79

1.4

1.2

u/ml

0.8

—

(3003327) Ova and parasites identified in Stool by Light microscopy

4.01

1.74

1.2

1.5

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

534

1.89

1.74

4.8

3.8

pmol/l

14.9

14.8

0.07

486

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

3.14

1.61

1.2

1.0

—

(3019832) Treponema pallidum Ab [Presence] in Serum

2.33

1.58

1.5

1.9

—

(3032080) INR in Blood by Coagulation assay

247

1.70

1.55

7.8

9.0

inr

1.1

1.2

1.39

(3048929) Epstein Barr virus Ab [Presence] in Serum

3.47

1.54

1.2

1.6

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.01

1.54

1.6

1.7

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

241

1.68

1.47

6.3

3.7

ng/l

15.0

23.2

1.41

157

(3000850) Epithelial cells [#/volume] in Urine

133

1.77

1.33

2.5

2.4

e6/l

4.0

3.4

0.18

121

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

168

1.69

1.29

3.6

4.6

20.7

20.6

0.02

(3021960) Folate [Moles/volume] in Serum or Plasma

151

1.71

1.29

1.7

1.4

nmol/l

24.4

22.5

0.24

124

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

645

1.87

1.25

5.4

4.4

mu/l

1.8

2.0

0.81

586

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

162

1.67

1.22

1.8

1.6

mmol/l

1.2

1.3

0.49

128

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

2.59

1.16

1.2

1.4

—

(3044640) Blood type and Crossmatch panel - Blood

190

1.61

1.16

2.8

2.1

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

508

1.60

1.16

3.1

2.5

u/l

38.6

43.1

0.49

482

(1761868) Lipid panel - Serum or Plasma

300

1.55

1.15

3.7

2.9

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.22

1.08

6.1

3.9

0.7

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.15

1.05

6.4

3.8

1.7

1.9

—

(3019225) pH of Specimen

1.98

1.04

1.6

5.0

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

118

1.66

1.01

1.8

1.4

—

(3020682) Albumin/Creatinine [Ratio] in Urine

170

1.57

1.00

4.9

3.7

mg/mmol

12.9

8.5

0.26

107

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

0.00

1.00

0.0

3.3

—

24.6

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

760

2.13

0.97

15.9

8.9

u/l

27.4

26.7

0.15

739

(1002224) Polysomnography panel

1.97

0.96

1.0

1.1

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.97

0.96

1.6

1.7

—

(3007164) IgA [Mass/volume] in Serum or Plasma

129

1.61

0.93

1.6

1.2

g/l

2.4

2.3

0.07

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

245

1.49

0.93

2.0

1.8

pmol/l

119.5

95.3

1.99

133

(3025941) Bacteria identified in Stool by Culture

2.23

0.93

1.2

—

(3028026) IgM [Mass/volume] in Serum or Plasma

2.23

0.93

1.3

1.5

g/l

1.0

1.3

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

121

1.62

0.92

3.3

2.6

ug/l

0.6

0.7

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

651

1.65

0.91

6.4

5.3

mmol/mol

39.4

39.5

0.01

608

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

183

1.52

0.90

3.1

3.2

ng/l

517.9

991.9

1.38

163

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.07

0.89

8.5

4.2

g/l

137.2

133.6

—

(3018095) Leukocytes [#/volume] in Urine

239

1.46

0.87

3.7

3.5

e6/l

11.3

59.5

2.59

165

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

305

1.44

0.86

4.9

6.7

mmol/l

1.2

0.19

259

(40761511) CBC panel - Blood by Automated count

735

1.92

0.85

17.1

12.2

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.81

0.85

1.5

1.6

—

(40758558) Short blood count panel - Blood

162

1.48

0.76

6.2

5.5

—

(40768804) Tissue Pathology biopsy report

273

1.41

0.75

2.9

2.1

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

1.62

0.74

2.1

2.5

g/l

2.4

2.3

0.17

(3020564) Creatinine [Moles/volume] in Serum or Plasma

755

1.85

0.67

19.7

14.2

umol/l

76.7

76.2

0.06

755

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

356

1.35

0.65

4.1

6.6

umol/l

8.9

10.4

1.40

339

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.61

0.0

2.2

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.61

0.0

2.6

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.60

0.0

1.5

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.77

0.59

1.5

2.3

—

(40768797) Stomach Pathology biopsy report

1.54

0.58

1.2

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

1.54

0.58

1.8

2.6

22.1

23.2

0.11

(3012516) Albumin [Mass/volume] in Urine

162

1.39

0.57

2.7

2.8

mg/l

100.2

59.3

0.32

101

(3003694) ABO and Rh group [Type] in Blood

178

0.68

0.56

1.9

1.4

—

(3023368) Bacteria identified in Blood by Culture

172

1.38

0.55

3.6

4.1

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.62

0.55

2.8

1.2

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.62

0.55

1.2

1.0

—

(3022948) Iron [Moles/volume] in Serum or Plasma

1.49

0.54

2.3

2.5

umol/l

12.3

14.6

0.65

(3022217) INR in Platelet poor plasma by Coagulation assay

1.54

0.54

24.6

16.3

—

1.2

—

(3022145) Colonoscopy Study observation

1.50

0.52

1.9

1.2

—

(3000991) Gas panel - Venous blood

1.50

0.48

6.1

4.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.50

0.48

2.3

1.8

—

(36304419) Bacteria [Presence] in Urine

186

1.32

0.47

2.5

2.7

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

1.65

0.44

2.2

1.9

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

669

1.35

0.42

18.3

11.7

ml/min/173m2

83.3

83.2

0.02

554

(3014007) Fractional oxyhemoglobin in Arterial blood

1.55

0.42

8.2

4.0

93.2

92.4

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.41

0.0

1.8

—

(3024928) Oxygen saturation in Venous blood

0.00

0.41

0.0

3.4

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.41

0.0

1.2

—

(3044889) 12 lead EKG panel

484

1.25

0.40

4.2

3.5

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.39

0.0

4.0

—

26.4

—

(21494755) Public health laboratory ask at order entry panel

0.71

0.33

1.3

1.5

—

(3009542) Hematocrit [Volume Fraction] of Blood

667

1.27

0.30

17.2

11.6

39.4

40.7

0.47

513

(3015377) Calcium [Moles/volume] in Serum or Plasma

226

1.22

0.29

2.5

4.0

mmol/l

2.4

0.06

203

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

134

1.24

0.25

2.4

2.2

—

(3033658) Prothrombin time (PT) actual/Normal

163

1.21

0.24

4.2

3.2

82.2

91.8

1.00

158

(3018418) pH of Serum or Plasma

193

1.19

0.22

1.9

4.0

7.4

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.21

0.0

1.1

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.21

0.0

2.8

—

68.6

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.21

0.0

3.5

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.21

0.0

1.3

—

(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay

0.00

0.21

0.0

2.0

—

0.6

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

243

1.16

0.20

3.1

3.0

—

(4035726)

1.20

0.18

1.4

1.5

—

(3000492) Spirometry study

1.14

0.18

1.3

1.4

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.14

0.18

1.1

1.3

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

140

1.18

0.16

3.9

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.18

0.11

2.2

1.8

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.11

0.08

2.3

1.8

—

(3002385) Erythrocyte distribution width [Ratio]

597

1.07

0.06

24.4

15.1

13.9

13.7

0.33

585

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

101

1.10

0.04

1.4

1.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

469

1.00

0.00

3.3

3.0

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

2.3

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.1

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

2.3

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

2.3

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

2.3

—

(44790048)

0.00

0.0

1.7

—

(44790049)

0.00

0.0

1.7

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.2

—

(44806118)

0.00

0.0

1.7

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(36660697) Celiac disease serology panel - Serum

1.00

0.00

1.6

1.1

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

0.97

0.00

1.5

1.8

—

(44790047)

0.00

0.0

1.7

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

2.3

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

2.3

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

2.8

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.2

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.0

2.0

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.2

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

1.3

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

16.4

—

1482.8

—

(3007853) Bacteria identified in Skin by Aerobe culture

0.98

0.00

2.9

1.5

—

(3035880) pH of Pleural fluid

0.00

0.0

1.0

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.0

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3011648) Oxygen content in Venous blood

0.00

0.0

2.7

—

14.5

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.0

—

(3000494) Fungus identified in Specimen by Culture

0.89

0.00

1.3

1.4

—

(3020650) Glucose [Presence] in Urine

0.00

0.0

1.2

—

(4146454)

0.00

0.0

2.4

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.2

—

(3025271) CD3-CD16+CD56+ (Natural killer) cells [#/volume] in Blood

0.00

0.0

1.8

—

0.1

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.02

0.00

6.9

7.7

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

6.6

—

0.4

—

(3017315) Amylase [Enzymatic activity/volume] in Urine

0.00

0.0

1.0

—

1916.4

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

13.2

—

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

19.1

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.2

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

10.6

—

976.2

—

(40761535) Cells panel - Urine sediment

0.92

0.00

3.2

3.6

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.7

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.0

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

1.2

—

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(4268621)

0.00

0.0

2.4

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

0.98

0.00

1.3

1.9

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.00

0.00

1.5

1.7

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

1.3

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_INTERHYDRARTHR and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_INTERHYDRARTHR.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: M13_INTERHYDRARTHR – Intermittent hydrarthrosis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Intermittent hydrarthrosis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints