Fracture of spine, level unspecified

ST19_FRACT_SPINE_LEVEL_UNSPE

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — T08 Cause of death: ICD-10 — T08 2 out of 7 registries used, show all original rules.	77
4. Check minimum number of events None	77
5. Include endpoints None	77
6. Filter based on genotype QC (FinnGen only)	73

Control definitions (FinnGen only)

Control exclude: ST19_INJURI_UNSPE_PART_TRUNK_LIMB_BODY_REGION

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: T0[8-9]|T1[0-4]
Name in latin: Fractura columnae vertebralis, regione non specificata

NAME	ST19_FRACT_SPINE_LEVEL_UNSPE
CONTROL_EXCLUDE	ST19_INJURI_UNSPE_PART_TRUNK_LIMB_BODY_REGION
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	T08
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	T08
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Fracture of spine, level unspecified based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	738	368	366
Only index persons	637	305	332
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	68.87	77.70	59.99
Only index persons	66.68	76.11	58.01

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	73	31	42
Unadjusted period prevalence (%)	0.02	0.01	0.02
Median age at first event (years)	66.67	63.08	69.32

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
77: Matched controls
770

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

T08

ICD-10 Finland

Fracture of spine, level unspecified

+∞

110.7

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

9.8

18.3

S32.0

ICD-10 Finland

Fracture of lumbar vertebra

19.9

15.3

W19

ICD-10 Finland

Unspecified fall

7.6

13.3

NA3AD

NOMESCO Finland

Lumbar spine and sacrum CT examination

26.7

12.7

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

5.2

11.8

164

NA2AA

NOMESCO Finland

Thoracal spine X-ray examination without contrast

30.5

11.7

X59

ICD-10 Finland

Exposure to unspecified factor

5.8

11.6

S22.0

ICD-10 Finland

Fracture of thoracic vertebra

19.4

11.5

NA2AD

NOMESCO Finland

Thoracic spine CT examination

100.6

8.6

S06.0

ICD-10 Finland

Concussion

5.4

7.9

W17

ICD-10 Finland

Other fall from one level to another

15.5

7.7

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

4.6

7.4

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

249

2.94

5.09

2.1

2.2

76.00

76.35

nmol/l

0.02

212

(3022217) INR in Platelet poor plasma by Coagulation assay

312

3.05

5.06

23.6

17.0

1.31

1.42

inr

0.31

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

305

2.82

4.52

10.5

5.7

1.21

mmol/l

0.02

264

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

262

2.59

4.02

2.4

1.9

90.83

91.11

pmol/l

0.01

128

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.74

3.55

2.0

1.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.97

3.41

2.1

1.4

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.92

3.32

2.1

1.5

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

4.10

3.00

5.8

6.0

—

(3023368) Bacteria identified in Blood by Culture

176

2.27

2.94

4.7

3.9

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.45

2.93

1.8

1.5

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

286

2.14

2.70

5.6

4.2

32.93

35.51

g/l

1.83

273

(3012544) pH of Venous blood

2.78

2.62

1.6

3.5

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.43

2.54

2.2

1.7

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

2.68

2.46

9.1

4.6

118.07

124.98

g/l

0.54

(1001926) Buprenorphine [Presence] in Urine by Screen method

5.32

2.45

6.5

1.4

—

(3016502) Oxygen saturation in Arterial blood

2.58

2.43

8.3

4.4

95.36

95.88

0.16

(3002032) Base excess in Venous blood by calculation

2.69

2.34

1.4

3.5

2.65

1.81

mmol/l

—

(3011288) Drugs identified in Urine by Screen method

5.26

2.10

2.0

1.6

—

(1616796) Gas panel - Central venous blood

5.26

2.10

3.0

3.3

—

(3016879) Cocaine [Presence] in Urine

4.24

2.08

11.0

1.4

—

(3000991) Gas panel - Venous blood

2.60

2.07

7.2

6.0

—

(36304419) Bacteria [Presence] in Urine

182

1.95

2.00

4.7

2.8

—

(3027008) Opiates [Presence] in Urine

3.97

1.97

10.8

1.4

—

(3000764) Benzodiazepines [Presence] in Urine

3.97

1.97

11.0

1.5

—

(3028300) Cannabinoids [Presence] in Urine

3.97

1.97

11.0

1.4

—

(3018572) Chloride [Moles/volume] in Blood

4.78

1.97

9.8

4.1

104.00

104.36

mmol/l

—

(3039000) Anion gap in Blood

4.78

1.97

9.8

4.1

10.00

10.36

mmol/l

—

(21494755) Public health laboratory ask at order entry panel

0.00

1.97

0.0

1.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

272

1.88

1.95

7.1

5.8

—

(3022313) Gas panel - Capillary blood

2.86

1.94

3.0

—

(3019309) Folate [Moles/volume] in Red Blood Cells

139

1.93

1.74

1.7

1.6

701.88

1134.62

nmol/l

2.48

109

(40760888) Immunoglobulin light chains.free panel - Serum

4.03

1.74

5.0

6.5

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

2.27

1.59

7.2

4.2

1.82

1.35

mmol/l

0.65

(3026008) Bacteria identified in Urine by Culture

207

1.74

1.47

6.8

3.1

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

216

1.73

1.46

3.5

3.1

2.32

2.36

mmol/l

0.84

184

(3027944) Amphetamines [Presence] in Urine

3.27

1.46

13.0

1.5

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

2.55

1.43

1.3

1.9

52.29

43.76

u/l

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

2.35

1.42

3.1

3.5

1.20

1.23

mmol/l

—

(3018095) Leukocytes [#/volume] in Urine

245

1.69

1.41

5.0

3.7

101.17

63.91

e6/l

0.32

173

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.29

1.39

2.2

1.5

—

(40768797) Stomach Pathology biopsy report

1.93

1.38

1.3

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

3.07

1.38

1.0

2.1

—

(3030467) Casts [#/volume] in Urine by Automated count

193

1.71

1.36

4.9

2.9

0.37

0.42

e6/l

0.07

145

(3002582) Erythrocytes [#/volume] in Urine

212

1.68

1.33

4.8

3.1

20.78

355.80

e6/l

0.57

163

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

260

1.63

1.27

5.0

4.1

23.82

46.12

ng/l

1.41

200

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

153

1.72

1.26

2.4

2.1

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

2.08

1.24

2.5

2.1

1.55

1.77

0.40

(3052851) Hemolysis interference index of Serum or Plasma

2.74

1.23

4.8

3.9

—

(3014007) Fractional oxyhemoglobin in Arterial blood

2.17

1.19

9.5

5.3

94.04

94.18

—

(3044640) Blood type and Crossmatch panel - Blood

209

1.62

1.17

2.7

2.1

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

343

1.57

1.12

2.4

2.7

—

(3022145) Colonoscopy Study observation

1.94

1.12

1.2

1.3

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

587

1.87

1.09

21.5

14.5

78.64

77.93

ml/min/173m2

0.09

484

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.81

1.06

2.0

4.9

106.00

103.52

mmol/l

1.34

(3031040) Bacteria [#/volume] in Urine by Automated count

427

1.58

1.05

7.8

4.4

—

341.82

—

(3019198) Lymphocytes [#/volume] in Blood

301

1.52

0.99

5.0

5.2

1.83

1.78

e9/l

0.08

266

(3001604) Monocytes [#/volume] in Blood

294

1.50

0.93

5.1

5.2

0.61

0.59

e9/l

0.10

256

(3006315) Basophils [#/volume] in Blood

295

1.49

0.91

5.0

5.2

0.04

e9/l

0.16

256

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

622

1.80

0.91

24.9

14.3

23.01

23.73

mg/l

0.07

496

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.91

0.89

9.5

4.8

1.65

1.46

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.91

0.89

9.5

4.8

0.75

0.68

—

(3037467) Urinalysis macro (dipstick) panel - Urine

426

1.50

0.87

7.1

4.2

—

(36660697) Celiac disease serology panel - Serum

1.82

0.85

1.4

—

(3019060) Gas panel - Arterial blood

1.82

0.85

6.5

2.7

—

(3003694) ABO and Rh group [Type] in Blood

159

1.54

0.85

1.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.83

0.84

2.3

1.8

—

(3041096) Erythrocytes [Presence] in Urine by Automated

169

1.51

0.82

4.4

3.4

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.80

0.0

2.6

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

660

1.97

0.79

13.2

10.2

27.35

24.82

u/l

0.47

642

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.69

0.77

1.8

1.3

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

2.16

0.76

3.4

2.8

82.40

108.97

u/ml

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

238

1.43

0.73

5.6

3.2

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

1.73

0.70

7.7

4.5

27.13

24.50

mmol/l

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

356

1.40

0.69

10.4

8.7

4.57

4.10

e9/l

0.57

305

(3013115) Eosinophils [#/volume] in Blood

307

1.40

0.69

5.2

0.17

0.18

e9/l

0.03

267

(3015736) pH of Urine

240

1.41

0.69

4.5

3.5

—

5.62

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.70

0.69

3.9

3.7

—

(3025941) Bacteria identified in Stool by Culture

1.69

0.69

1.4

1.2

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

451

1.39

0.63

4.0

3.6

14.76

14.98

pmol/l

0.29

405

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

293

1.36

0.60

3.1

2.4

—

(3019225) pH of Specimen

1.59

0.60

2.9

3.8

—

(3000492) Spirometry study

1.48

0.55

1.4

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.54

0.53

3.0

2.3

—

(3044889) 12 lead EKG panel

418

1.32

0.51

4.5

4.1

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.59

0.49

8.6

7.9

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

588

1.39

0.46

4.3

4.1

1.27

1.26

mmol/l

0.05

531

(3021589) Normoblasts [#/volume] in Blood

273

1.29

0.46

15.0

8.7

0.00

e9/l

0.50

227

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.41

0.0

1.3

—

(40768793) Breast Pathology biopsy report

0.00

0.41

0.0

1.1

—

(40768800) Prostate Pathology biopsy report

0.00

0.40

0.0

1.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.37

0.39

2.1

1.7

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.39

0.0

1.4

—

219.89

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

156

0.73

0.39

2.1

1.6

1.57

1.19

mmol/l

—

128

(3000330) Specific gravity of Urine by Test strip

1.42

0.39

4.8

3.8

—

(3002256) Pathology report gross observation

0.63

0.38

1.2

1.3

—

(3029937) Albumin [Presence] in Urine by Test strip

165

0.74

0.37

8.0

3.7

0.00

estimate

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

605

1.34

0.37

4.5

4.6

1.40

1.44

mmol/l

0.33

549

(3012516) Albumin [Mass/volume] in Urine

194

1.26

0.35

4.2

2.9

2188.50

58.15

mg/l

0.48

124

(3021601) Nitrite [Presence] in Urine by Test strip

301

1.23

0.34

7.5

5.1

0.00

estimate

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.35

0.29

2.5

1.7

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

1.30

0.29

1.3

2.4

10.09

12.58

nmol/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.23

0.26

1.2

—

(3009261) Glucose [Presence] in Urine by Test strip

308

1.19

0.25

5.4

3.7

0.00

estimate

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

116

1.25

0.24

5.2

2.9

0.59

1.04

e6/l

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.23

0.22

1.8

3.8

1.00

0.17

e6/l

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.23

0.22

2.2

1.6

—

(40758558) Short blood count panel - Blood

146

1.21

0.21

4.9

7.6

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.21

0.0

1.3

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.3

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3020682) Albumin/Creatinine [Ratio] in Urine

204

1.18

0.21

4.5

3.5

2.75

8.62

mg/mmol

1.51

127

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.21

0.0

1.1

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

4.8

—

73.83

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.4

—

(40761511) CBC panel - Blood by Automated count

648

1.26

0.21

22.7

14.2

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.9

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

0.00

0.20

0.0

1.3

—

27.89

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.9

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.19

0.20

3.8

2.6

—

(3035350) Ketones [Presence] in Urine by Test strip

304

1.15

0.19

5.3

3.6

0.00

estimate

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

140

1.18

0.16

4.9

3.5

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

112

1.19

0.15

5.8

3.2

1.69

3.02

e6/l

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

621

1.18

0.15

5.3

5.2

2.71

2.61

mmol/l

0.37

565

(1761868) Lipid panel - Serum or Plasma

200

0.87

0.14

4.1

3.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

232

1.11

0.11

6.2

3.8

—

(3042936) Bacteria identified in Isolate by Culture

1.19

0.11

2.2

1.8

—

(3000494) Fungus identified in Specimen by Culture

0.77

0.08

1.2

1.5

—

(3013512) EKG study

210

1.07

0.04

6.3

4.0

—

(40768804) Tissue Pathology biopsy report

259

0.95

0.03

1.6

2.3

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

218

1.01

0.00

4.5

4.9

31.19

19.90

1.25

109

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

279

1.01

0.00

4.8

5.3

1.52

2.16

ug/l

1.43

236

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.3

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

2.5

—

31.83

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.3

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.3

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

0.00

0.0

1.5

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

0.0

1.8

—

1.80

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.5

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.3

—

(3050898) Methicillin resistant Staphylococcus aureus [Presence] in Genital specimen by Organism specific culture

0.00

0.0

2.0

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.3

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

1.0

—

(4200892) Spirometry reversibility

0.96

-0.00

1.2

1.3

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(40763470) Parainfluenza virus 4 RNA [Presence] in Isolate by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

187.83

—

(40768795) Lymph node Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(3005033) Fetal Nuchal fold Thickness US

0.00

-0.00

0.0

1.4

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.4

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

-0.00

0.0

1.6

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3045788) Cell count panel - Pleural fluid

0.00

-0.00

0.0

1.2

—

(40761536) Microorganisms panel - Urine sediment

0.90

-0.00

9.2

2.9

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

8.2

—

220.00

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

-0.00

0.0

1.3

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

-0.00

0.0

1.4

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.2

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

0.93

-0.00

2.8

1.7

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

1.03

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

-0.00

0.0

2.0

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.5

—

10.72

—

(3045142) Bone marrow Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(40763324) Parainfluenza virus 1 RNA [Presence] in Isolate by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.3

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

-0.00

0.0

1.0

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

-0.00

0.0

1.0

—

(21494434) Karyotype in Bone marrow

0.00

-0.00

0.0

1.0

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

-0.00

0.0

1.3

—

(4035726) Immunohistochemistry procedure

1.02

-0.00

1.3

1.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint ST19_FRACT_SPINE_LEVEL_UNSPE and mortality.

Females

Parameter	HR [95% CI]	p-value
ST19_FRACT_SPINE_LEVEL_UNSPE	1.876 [1.28, 2.74]	0.001
Birth year	0.995 [0.99, 1.0]	0.263

During the follow-up period (1.1.1998 — 31.12.2019), 119 out of 271 females with ST19_FRACT_SPINE_LEVEL_UNSPE died.

Males

Parameter	HR [95% CI]	p-value
ST19_FRACT_SPINE_LEVEL_UNSPE	2.304 [1.4, 3.78]	0.001
Birth year	0.988 [0.98, 1.0]	0.014

During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 280 males with ST19_FRACT_SPINE_LEVEL_UNSPE died.

Mortality risk

Mortality risk for people of age

years, who have ST19_FRACT_SPINE_LEVEL_UNSPE.

N-year risk	Females	Males
1	0.23%	0.388%
5	1.078%	2.665%
10	2.559%	6.877%
15	5.06%	12.868%
20	8.965%	21.156%

Relationships between endpoints

↥

Index endpoint: ST19_FRACT_SPINE_LEVEL_UNSPE – Fracture of spine, level unspecified

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Fracture of spine, level unspecified

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints