Fracture of spine, level unspecified

ST19_FRACT_SPINE_LEVEL_UNSPE

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — T08 Cause of death: ICD-10 — T08 2 out of 7 registries used, show all original rules.	67
4. Check minimum number of events None	67
5. Include endpoints None	67
6. Filter based on genotype QC (FinnGen only)	67

Control definitions (FinnGen only)

Control exclude: ST19_INJURI_UNSPE_PART_TRUNK_LIMB_BODY_REGION

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: T0[8-9]|T1[0-4]
Name in latin: Fractura columnae vertebralis, regione non specificata

NAME	ST19_FRACT_SPINE_LEVEL_UNSPE
CONTROL_EXCLUDE	ST19_INJURI_UNSPE_PART_TRUNK_LIMB_BODY_REGION
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	T08
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	T08
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Fracture of spine, level unspecified based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	738	368	366
Only index persons	637	305	332
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	68.87	77.70	59.99
Only index persons	66.68	76.11	58.01

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	67	32	35
Unadjusted period prevalence (%)	0.01	0.01	0.02
Median age at first event (years)	65.38	65.02	65.71

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
59: Matched controls
587

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

T08

ICD-10 Finland

Fracture of spine, level unspecified

+∞

84.6

S32.0

ICD-10 Finland

Fracture of lumbar vertebra

16.9

11.9

S22.0

ICD-10 Finland

Fracture of thoracic vertebra

54.3

11.4

NA2AA

NOMESCO Finland

Thoracal spine X-ray examination without contrast

20.3

9.0

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

6.4

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

219

3.05

4.73

2.0

2.2

78.15

75.87

nmol/l

0.15

185

(3032080) INR in Blood by Coagulation assay

228

3.06

4.71

9.3

8.6

1.17

1.34

inr

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

222

2.64

3.70

2.5

1.9

89.11

90.76

pmol/l

0.08

102

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.84

3.68

1.8

1.5

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

4.78

3.12

9.3

4.9

26.51

25.17

mmol/l

—

(42870588) Differential panel, method unspecified - Blood

183

2.29

2.74

5.6

5.0

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

4.39

2.66

6.8

—

(3012544) pH of Venous blood

3.03

2.61

1.7

3.6

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.68

2.50

2.3

1.7

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

242

2.18

2.49

4.0

4.2

33.01

35.49

g/l

1.43

229

(1001926) Buprenorphine [Presence] in Urine by Screen method

5.37

2.46

6.5

1.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.46

2.45

2.2

1.8

—

(1616796) Gas panel - Central venous blood

6.64

2.41

3.0

3.5

—

(3000991) Gas panel - Venous blood

2.86

2.22

7.6

6.7

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

4.59

2.20

9.3

3.3

0.93

0.81

—

(3023368) Bacteria identified in Blood by Culture

146

2.14

2.18

5.2

3.9

—

(3011288) Drugs identified in Urine by Screen method

5.30

2.11

2.0

1.6

—

(3000764) Benzodiazepines [Presence] in Urine

4.28

2.09

11.0

1.5

—

(3016879) Cocaine [Presence] in Urine

4.28

2.09

11.0

1.4

—

(3016502) Oxygen saturation in Arterial blood

2.59

2.01

10.0

4.9

94.60

95.73

0.34

(3027008) Opiates [Presence] in Urine

4.01

1.98

10.8

1.4

—

(3028300) Cannabinoids [Presence] in Urine

4.01

1.98

11.0

1.4

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

2.66

1.97

11.2

5.2

120.73

123.67

g/l

0.15

(3022313) Gas panel - Capillary blood

3.10

1.93

3.0

3.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.45

1.92

2.4

1.4

—

(40768797) Stomach Pathology biopsy report

2.25

1.89

1.3

1.2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.40

1.86

2.4

1.5

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.73

1.82

2.2

1.4

—

(21494755) Public health laboratory ask at order entry panel

0.00

1.78

0.0

1.3

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

219

1.88

1.72

5.1

4.3

21.43

40.97

ng/l

1.31

167

(3019309) Folate [Moles/volume] in Red Blood Cells

112

1.97

1.57

1.8

1.6

653.28

1121.58

nmol/l

2.77

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

2.77

1.56

1.3

1.8

52.29

39.28

u/l

—

(3019198) Lymphocytes [#/volume] in Blood

263

1.80

1.52

5.0

5.4

1.79

1.77

e9/l

0.02

233

(3022145) Colonoscopy Study observation

2.29

1.48

1.2

1.3

—

(3027944) Amphetamines [Presence] in Urine

3.29

1.46

13.0

1.5

—

(3001604) Monocytes [#/volume] in Blood

257

1.76

1.43

5.1

5.4

0.56

0.59

e9/l

0.31

225

(3006315) Basophils [#/volume] in Blood

259

1.74

1.38

5.1

5.4

0.04

e9/l

0.11

226

(3044640) Blood type and Crossmatch panel - Blood

169

1.76

1.34

2.9

2.1

—

(36304419) Bacteria [Presence] in Urine

154

1.75

1.26

5.2

2.7

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

190

1.71

1.24

1.8

3.2

2.33

2.36

mmol/l

0.45

159

(36660697) Celiac disease serology panel - Serum

2.13

1.16

1.4

1.2

—

(3009542) Hematocrit [Volume Fraction] of Blood

475

1.88

1.14

24.4

14.4

39.54

39.86

0.14

329

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

124

1.74

1.13

2.5

2.0

—

(3013115) Eosinophils [#/volume] in Blood

271

1.61

1.08

5.3

0.18

0.17

e9/l

0.03

237

(3026008) Bacteria identified in Urine by Culture

178

1.65

1.08

6.8

3.1

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

2.37

1.05

3.4

3.0

82.40

117.65

u/ml

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.96

1.04

4.2

4.0

—

(3031040) Bacteria [#/volume] in Urine by Automated count

369

1.56

0.91

7.4

4.4

—

31.10

—

(3014007) Fractional oxyhemoglobin in Arterial blood

2.03

0.87

12.2

6.3

93.33

94.39

—

(3018095) Leukocytes [#/volume] in Urine

208

1.50

0.80

5.5

3.6

52.98

57.41

e6/l

0.05

146

(3013650) Neutrophils [#/volume] in Blood by Automated count

314

1.49

0.80

10.0

8.7

4.45

4.10

e9/l

0.36

269

(3007853) Bacteria identified in Skin by Aerobe culture

1.80

0.79

2.2

1.9

—

(3000492) Spirometry study

1.80

0.79

1.4

1.5

—

(3019225) pH of Specimen

1.78

0.77

3.1

4.1

—

(3002582) Erythrocytes [#/volume] in Urine

175

1.48

0.71

5.4

3.0

22.31

403.81

e6/l

0.53

135

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

309

1.44

0.71

2.6

2.7

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

508

1.62

0.70

22.6

14.1

78.88

78.37

ml/min/173m2

0.05

417

(3015736) pH of Urine

205

1.44

0.67

3.3

3.4

—

(3030467) Casts [#/volume] in Urine by Automated count

160

1.46

0.64

5.7

2.9

0.50

0.46

e6/l

0.05

121

(3003694) ABO and Rh group [Type] in Blood

133

1.48

0.64

1.4

1.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.66

0.62

2.0

1.3

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.84

0.60

3.0

2.2

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.78

0.59

12.2

5.7

0.73

0.67

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.78

0.59

12.2

5.7

1.73

1.46

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

539

1.57

0.59

25.1

14.1

20.86

22.66

mg/l

0.19

432

(3020891) Body temperature

0.00

0.59

0.0

3.3

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.59

0.0

2.6

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

397

1.41

0.59

4.0

3.7

14.80

15.02

pmol/l

0.26

358

(3021589) Normoblasts [#/volume] in Blood

238

1.39

0.59

15.6

8.8

0.00

e9/l

0.50

201

(3019060) Gas panel - Arterial blood

1.73

0.58

8.2

2.8

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

575

1.68

0.57

13.0

10.3

28.21

24.98

u/l

0.54

559

(3025941) Bacteria identified in Stool by Culture

1.59

0.54

1.5

1.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

147

1.41

0.53

4.4

3.3

—

(3037467) Urinalysis macro (dipstick) panel - Urine

370

1.36

0.53

6.3

4.2

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

243

1.34

0.50

5.3

3.7

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

1.56

0.42

10.0

4.8

28.26

24.44

mmol/l

—

(3042936) Bacteria identified in Isolate by Culture

1.48

0.42

2.2

1.8

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

200

1.31

0.42

5.5

3.1

—

(40768793) Breast Pathology biopsy report

0.00

0.42

0.0

1.1

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.41

0.0

1.3

—

220.00

—

(40768443) Skin Pathology biopsy report

0.00

0.41

0.0

1.1

—

(3029937) Albumin [Presence] in Urine by Test strip

145

0.71

0.40

6.8

3.6

0.00

estimate

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.37

0.35

3.8

2.8

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

139

0.75

0.30

1.6

1.17

1.21

mmol/l

—

115

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.24

0.28

2.3

1.7

—

(3044889) 12 lead EKG panel

359

1.21

0.26

4.9

4.0

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

525

1.27

0.24

4.4

4.5

1.39

1.46

mmol/l

0.40

474

(3021601) Nitrite [Presence] in Urine by Test strip

262

1.19

0.23

6.4

5.1

0.00

estimate

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.24

0.22

2.2

1.7

—

(40768800) Prostate Pathology biopsy report

0.00

0.21

0.0

1.4

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.5

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

5.5

—

86.90

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

31.43

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.21

0.0

1.2

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.20

0.0

1.1

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.9

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.9

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.21

0.19

2.7

1.7

—

(3013512) EKG study

178

1.18

0.18

6.4

3.9

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.16

0.17

1.3

1.2

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

123

1.17

0.14

3.3

3.5

—

(40758558) Short blood count panel - Blood

126

1.14

0.10

4.4

8.2

—

(3035350) Ketones [Presence] in Urine by Test strip

264

1.10

0.10

4.6

3.6

0.00

estimate

—

(4010399)

1.07

0.09

1.2

1.3

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

164

0.89

0.09

3.3

5.0

24.68

19.32

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

0.85

0.07

3.0

1.7

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

213

0.91

0.07

3.5

5.1

1.64

2.28

ug/l

1.01

180

(40761511) CBC panel - Blood by Automated count

567

1.17

0.07

22.6

13.5

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

539

1.11

0.06

5.1

2.77

2.64

mmol/l

0.46

487

(40768804) Tissue Pathology biopsy report

228

1.08

0.06

1.7

2.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

101

1.11

0.04

8.2

5.4

—

(3020682) Albumin/Creatinine [Ratio] in Urine

172

1.06

0.02

3.8

3.7

1.90

9.79

mg/mmol

2.03

106

(1761868) Lipid panel - Serum or Plasma

175

1.04

0.00

4.1

3.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

204

0.97

0.00

5.4

3.7

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.6

—

(4035726)

0.94

0.00

1.4

1.3

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.5

—

10.72

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

3.0

—

3.94

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.0

—

(44790047)

0.00

0.0

1.6

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

0.0

1.8

—

1.18

—

(43055120) Cytomegalovirus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

0.0

1.8

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.3

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

1.3

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.0

1.1

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.3

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.3

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.0

2.0

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.0

2.4

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.3

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

4.1

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.2

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.3

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.5

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.4

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

8.2

—

220.00

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.0

1.0

—

(40761536) Microorganisms panel - Urine sediment

1.02

0.00

9.2

2.9

—

(3050898) Methicillin resistant Staphylococcus aureus [Presence] in Genital specimen by Organism specific culture

0.00

0.0

2.0

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.0

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.2

—

(44790048)

0.00

0.0

1.6

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(44806118)

0.00

0.0

1.6

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.4

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(44790049)

0.00

0.0

1.6

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.4

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

2.5

—

31.83

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.0

1.3

—

(3000494) Fungus identified in Specimen by Culture

0.85

0.00

1.2

1.5

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.4

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.0

1.0

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

1.8

—

Mortality – FinRegistry

↥

Association

Association between endpoint ST19_FRACT_SPINE_LEVEL_UNSPE and mortality.

Females

Parameter	HR [95% CI]	p-value
ST19_FRACT_SPINE_LEVEL_UNSPE	1.876 [1.28, 2.74]	0.001
Birth year	0.995 [0.99, 1.0]	0.263

During the follow-up period (1.1.1998 — 31.12.2019), 119 out of 271 females with ST19_FRACT_SPINE_LEVEL_UNSPE died.

Males

Parameter	HR [95% CI]	p-value
ST19_FRACT_SPINE_LEVEL_UNSPE	2.304 [1.4, 3.78]	0.001
Birth year	0.988 [0.98, 1.0]	0.014

During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 280 males with ST19_FRACT_SPINE_LEVEL_UNSPE died.

Mortality risk

Mortality risk for people of age

years, who have ST19_FRACT_SPINE_LEVEL_UNSPE.

N-year risk	Females	Males
1	0.23%	0.388%
5	1.078%	2.665%
10	2.559%	6.877%
15	5.06%	12.868%
20	8.965%	21.156%

Relationships between endpoints

↥

Index endpoint: ST19_FRACT_SPINE_LEVEL_UNSPE – Fracture of spine, level unspecified

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Fracture of spine, level unspecified

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints