Nocardiosis

AB1_NOCARDIOSIS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — A43 Cause of death: ICD-10 — A43 2 out of 7 registries used, show all original rules.	34
4. Check minimum number of events None	34
5. Include endpoints None	34
6. Filter based on genotype QC (FinnGen only)	34

Control definitions (FinnGen only)

Control exclude: AB1_OTHER_BACTERIAL

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF5

NAME	AB1_NOCARDIOSIS
CONTROL_EXCLUDE	AB1_OTHER_BACTERIAL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	A43
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	A43
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Nocardiosis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	241	107	132
Only index persons	196	83	113
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	62.77	64.15	61.68
Only index persons	60.79	59.96	61.40

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	34	12	22
Unadjusted period prevalence (%)	0.01	0.00	0.01
Median age at first event (years)	63.61	62.74	64.09

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

11.39

8.01

14.5

6.4

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

+∞

7.55

1.4

0.0

—

(3006695) Toxoplasma gondii DNA [Presence] in Specimen by NAA with probe detection

+∞

5.33

2.4

0.0

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

14.40

5.08

9.9

2.6

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

14.40

5.08

4.6

1.4

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

12.58

4.80

4.3

1.4

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

17.06

4.80

7.1

2.0

172.9

178.4

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

17.06

4.80

1.6

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

14.20

4.49

2.4

1.3

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

14.20

4.49

3.6

1.2

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

12.15

4.22

7.4

1.7

90.4

95.1

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

4.75

4.06

17.3

6.3

1.0

1.1

mmol/l

0.44

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

14.12

3.92

1.7

1.6

—

(3042936) Bacteria identified in Isolate by Culture

4.77

3.85

4.6

1.7

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

4.16

3.60

4.7

1.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

4.06

3.48

2.7

2.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

4.30

3.40

2.3

1.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

4.31

3.19

2.6

1.3

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

5.80

3.14

15.5

7.6

0.9

1.0

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

5.80

3.14

16.3

7.6

0.8

0.7

—

(4306422)

11.39

3.07

1.2

1.0

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

4.15

3.05

2.2

1.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

4.01

2.92

3.4

1.5

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

3.80

2.90

7.3

2.1

2.4

2.3

g/l

0.07

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

5.98

2.89

18.7

8.4

24.0

25.2

mmol/l

—

(3000991) Gas panel - Venous blood

5.16

2.89

33.0

9.1

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

9.48

2.84

1.2

—

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

9.48

2.84

6.2

1.3

311.6

240.8

ug/l

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

9.48

2.84

3.4

1.2

—

(3012544) pH of Venous blood

4.89

2.77

17.5

3.7

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

4.64

2.66

2.5

1.5

—

(3000093) Morphology [Interpretation] in Blood Narrative

8.11

2.64

1.0

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

8.11

2.64

1.2

1.4

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

7.08

2.46

5.0

1.1

14.0

10.5

mg/l

—

(4035726)

4.22

2.45

3.3

1.3

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

5.35

2.38

3.2

1.2

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

4.03

2.36

2.1

1.5

—

(3000494) Fungus identified in Specimen by Culture

3.41

2.34

3.4

1.5

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

5.12

2.01

1.4

—

(3023368) Bacteria identified in Blood by Culture

2.65

1.93

15.1

3.4

—

(3044640) Blood type and Crossmatch panel - Blood

2.58

1.87

5.6

2.0

—

(42870588) Differential panel, method unspecified - Blood

2.58

1.87

36.1

5.1

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

3.81

1.84

36.7

7.4

1.2

1.0

mmol/l

—

(3019832) Treponema pallidum Ab [Presence] in Serum

3.81

1.84

1.2

1.9

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.62

1.78

6.2

2.0

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

267

0.39

1.76

5.4

4.6

4.4

mmol/l

0.32

247

(3004588) Protein electrophoresis panel - Serum or Plasma

3.60

1.75

1.3

3.3

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

2.47

1.73

8.0

2.5

298.4

119.3

ug/l

0.84

(3007853) Bacteria identified in Skin by Aerobe culture

3.12

1.68

2.6

1.5

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

265

0.40

1.65

5.4

4.5

1.3

1.4

mmol/l

0.85

242

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

272

0.40

1.60

6.2

5.3

2.8

2.6

mmol/l

0.30

247

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

2.39

1.55

3.4

2.5

58.2

60.4

u/l

0.10

(3026493) Urate [Moles/volume] in Serum or Plasma

2.35

1.50

4.5

3.2

363.4

3569.8

umol/l

0.49

(3010813) Leukocytes [#/volume] in Blood

298

0.39

1.48

91.3

20.1

7.0

6.5

e9/l

0.55

290

(3026361) Erythrocytes [#/volume] in Blood

297

0.40

1.44

91.3

20.2

4.1

4.5

e12/l

2.72

289

(3007461) Platelets [#/volume] in Blood

297

0.40

1.44

91.3

20.2

242.0

237.1

e9/l

0.11

290

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.26

1.41

1.8

1.2

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

124

2.21

1.38

6.2

3.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

2.36

1.27

3.9

3.5

—

(3002256) Pathology report gross observation

2.33

1.10

1.9

1.3

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

123

1.98

1.08

30.7

5.6

1.2

mmol/l

0.07

111

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

260

0.50

1.03

4.4

3.9

1.5

1.2

mmol/l

1.57

237

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

267

0.50

0.98

6.3

4.6

6.5

6.0

mmol/l

0.65

244

(40758558) Short blood count panel - Blood

2.00

0.98

35.3

6.8

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

138

1.85

0.91

29.1

5.4

10.4

13.5

umol/l

0.54

130

(3022096) Basophils/100 leukocytes in Blood

112

1.81

0.84

39.8

5.9

0.6

0.7

0.19

106

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

286

0.53

0.84

42.1

10.2

26.8

26.6

u/l

0.02

279

(3020564) Creatinine [Moles/volume] in Serum or Plasma

285

0.54

0.82

70.0

16.2

110.0

84.4

umol/l

0.59

285

(3000492) Spirometry study

2.37

0.80

4.2

1.6

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

2.06

0.80

1.4

1.2

—

(3013115) Eosinophils [#/volume] in Blood

125

1.72

0.74

37.6

6.2

0.2

e9/l

0.07

112

(3006504) Eosinophils/100 leukocytes in Blood

117

1.69

0.70

40.9

6.0

2.3

2.7

0.22

111

(3019225) pH of Specimen

1.92

0.69

8.6

4.5

—

(3019069) Monocytes/100 leukocytes in Blood

119

1.65

0.64

42.0

6.3

11.1

8.7

0.66

113

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

248

0.60

0.63

8.9

5.5

43.3

40.5

mmol/mol

0.41

227

(3003694) ABO and Rh group [Type] in Blood

1.73

0.61

1.6

1.3

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

279

0.61

80.5

15.4

4.1

4.0

mmol/l

0.40

272

(40761511) CBC panel - Blood by Automated count

279

0.61

57.3

12.9

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

278

0.62

0.60

80.4

15.2

138.7

139.7

mmol/l

1.60

271

(3006315) Basophils [#/volume] in Blood

121

1.61

0.59

36.3

6.2

0.0

e9/l

0.99

109

(3001604) Monocytes [#/volume] in Blood

121

1.61

0.59

36.3

6.1

0.7

0.6

e9/l

0.45

109

(3018010) Neutrophils/100 leukocytes in Blood

122

1.59

0.57

37.4

6.0

57.4

57.9

0.05

116

(3041096) Erythrocytes [Presence] in Urine by Automated

0.55

0.54

4.0

3.2

—

(3002030) Lymphocytes/100 leukocytes in Blood

124

1.55

0.52

41.4

6.2

25.7

26.6

0.10

118

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

1.59

0.51

3.8

2.0

166.8

189.5

u/l

0.09

(3021960) Folate [Moles/volume] in Serum or Plasma

1.61

0.51

2.6

1.4

19.5

20.8

nmol/l

0.16

(3019198) Lymphocytes [#/volume] in Blood

126

1.51

0.47

35.7

6.4

1.5

1.8

e9/l

0.54

115

(3022145) Colonoscopy Study observation

1.72

0.45

1.4

—

(3026782) Osmolality of Urine

1.43

0.44

3.0

2.1

489.5

523.8

mosm/kgh2o

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

1.60

0.43

1.4

5.5

2.2

5.6

ug/l

—

(3003338) MCHC [Mass/volume]

219

0.70

0.37

89.6

16.8

328.9

332.6

g/l

1.05

219

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

104

0.70

0.36

4.6

3.7

—

(3019309) Folate [Moles/volume] in Red Blood Cells

1.43

0.34

2.0

1.5

609.6

1299.7

nmol/l

—

(3044889) 12 lead EKG panel

196

0.73

0.30

9.2

3.9

—

(3013512) EKG study

0.70

0.28

3.7

4.6

—

(3013707) Erythrocyte sedimentation rate by Westergren method

194

0.75

0.27

19.0

4.4

18.9

13.5

mm/h

0.56

182

(40768797) Stomach Pathology biopsy report

1.26

0.23

1.2

1.3

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.22

0.0

1.8

—

298.8

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.22

0.0

1.3

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.21

0.0

2.7

—

7.9

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.21

0.0

2.7

—

4.8

—

(3010421) pH of Blood

0.00

0.21

0.0

2.8

—

7.4

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.21

0.0

1.5

—

(3012501) Base excess in Blood by calculation

0.00

0.21

0.0

2.7

—

3.1

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.21

0.0

1.1

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

110

1.29

0.21

4.2

2.3

71.7

77.2

nmol/l

0.38

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

76.9

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.8

—

34.0

—

(3020961) Endomysium IgA Ab [Titer] in Serum

0.00

0.21

0.0

1.0

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

1.23

0.19

2.4

1.9

427.3

452.9

pmol/l

—

(40768804) Tissue Pathology biopsy report

112

1.26

0.18

5.1

2.1

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

1.27

0.17

5.0

2.9

2.4

mmol/l

0.24

(3015736) pH of Urine

1.27

0.17

3.8

3.4

—

(3009542) Hematocrit [Volume Fraction] of Blood

226

0.81

0.14

88.8

13.2

38.8

41.2

0.99

166

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

108

1.17

0.09

7.4

2.8

—

(3026008) Bacteria identified in Urine by Culture

1.11

0.08

3.3

2.2

—

(36304419) Bacteria [Presence] in Urine

0.88

0.08

9.6

2.5

—

(3018095) Leukocytes [#/volume] in Urine

111

0.86

0.07

10.3

3.2

5.4

108.6

e6/l

—

(3037467) Urinalysis macro (dipstick) panel - Urine

189

1.14

0.07

8.0

4.0

—

(3031040) Bacteria [#/volume] in Urine by Automated count

190

0.89

0.05

9.4

4.0

—

83.8

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

179

0.90

0.04

6.5

2.6

89.4

51.4

u/l

0.51

170

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

192

1.10

0.03

4.3

3.6

13.9

15.0

pmol/l

1.65

175

(3002582) Erythrocytes [#/volume] in Urine

103

0.96

0.00

8.3

2.6

9.9

632.2

e6/l

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

214

0.95

0.00

37.9

6.6

106.5

76.3

u/l

0.69

206

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

166

1.05

0.00

3.1

2.6

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.4

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(3016879) Cocaine [Presence] in Urine

0.00

0.0

1.1

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(4281824)

0.00

0.0

1.0

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.0

3.8

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.5

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.0

1.0

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.0

1.3

—

(3027008) Opiates [Presence] in Urine

0.00

0.0

1.1

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.1

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.0

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.0

1.0

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

1.3

—

87.6

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.0

2.8

—

59.4

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.0

1.8

—

1.5

—

(3030467) Casts [#/volume] in Urine by Automated count

1.05

0.00

8.7

2.6

0.2

0.4

e6/l

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.0

1.0

—

(3000850) Epithelial cells [#/volume] in Urine

0.93

0.00

3.1

2.2

1.3

4.2

e6/l

—

(3009214) Lutropin [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

4.7

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.0

1.0

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

3.5

—

20.9

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.0

1.1

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.0

2.8

—

4.4

—

(1616796) Gas panel - Central venous blood

0.00

0.0

4.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_NOCARDIOSIS and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
AB1_NOCARDIOSIS	3.248 [1.86, 5.68]	< 0.001
Birth year	0.983 [0.97, 0.99]	< 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 117 males with AB1_NOCARDIOSIS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_NOCARDIOSIS.

N-year risk	Females	Males
1	No data	0.523%
5	No data	3.446%
10	No data	8.776%
15	No data	15.743%
20	No data	25.32%

Relationships between endpoints

↥

Index endpoint: AB1_NOCARDIOSIS – Nocardiosis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Nocardiosis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints