Risteys · AB1_NOCARDIOSIS

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — A43 Cause of death: ICD-10 — A43 2 out of 7 registries used, show all original rules.	35
4. Check minimum number of events None	35
5. Include endpoints None	35
6. Filter based on genotype QC (FinnGen only)	32

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	241	107	132
Only index persons	196	83	113
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	62.77	64.15	61.68
Only index persons	60.79	59.96	61.40

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	32	12	20
Unadjusted period prevalence (%)	0.01	0.00	0.01
Median age at first event (years)	64.46	62.74	65.49

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3037692) Legionella sp identified in Specimen by Organism specific culture

+∞

7.54

1.4

0.0

—

(3025271) CD3-CD16+CD56+ (Natural killer) cells [#/volume] in Blood

+∞

6.43

4.5

0.0

0.23

—

e9/l

—

(3001405) CD3+CD8+ (T8 suppressor) cells [#/volume] in Blood

+∞

6.43

4.5

0.0

723.50

—

e6/l

—

(3011412) CD3 cells [#/volume] in Blood

+∞

6.43

4.7

0.0

1.28

—

e9/l

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

11.72

6.11

14.0

6.1

—

(3006695) Toxoplasma gondii DNA [Presence] in Specimen by NAA with probe detection

+∞

5.33

2.4

0.0

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

14.29

5.07

6.6

1.7

92.25

95.14

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

14.29

5.07

4.6

1.4

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

12.48

4.79

4.3

1.4

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

12.48

4.79

9.9

2.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

5.02

4.78

4.6

1.6

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

14.11

4.48

3.6

1.2

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

14.11

4.48

2.4

1.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

4.64

4.34

2.7

2.0

—

(3042936) Bacteria identified in Isolate by Culture

5.33

3.98

4.6

1.5

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

6.33

3.66

15.8

7.3

0.77

0.81

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

6.33

3.66

15.1

7.3

0.94

1.10

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

4.82

3.66

2.3

1.5

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

11.69

3.64

1.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

5.04

3.58

2.6

1.3

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

6.56

3.42

17.9

7.9

23.88

25.17

mmol/l

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

4.69

3.37

3.4

1.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

4.69

3.37

2.3

1.5

—

(3000991) Gas panel - Venous blood

5.38

3.26

30.8

8.3

—

(4035726) Immunohistochemistry procedure

5.12

3.14

3.0

1.4

—

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

11.34

3.07

6.2

1.4

311.60

189.00

ug/l

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

6.42

3.04

19.3

3.9

24.34

25.06

mmol/l

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

4.10

2.99

7.3

1.6

2.38

2.36

g/l

0.05

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

9.44

2.84

3.4

1.2

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

6.97

2.82

2.5

1.4

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

4.47

2.81

2.2

1.4

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

3.95

2.71

28.8

5.5

106.20

103.81

mmol/l

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

4.61

2.65

2.5

1.5

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

8.08

2.63

1.2

1.4

—

(3000093) Morphology [Interpretation] in Blood Narrative

8.08

2.63

1.0

—

(3023368) Bacteria identified in Blood by Culture

3.04

2.52

14.9

3.5

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

7.05

2.45

2.6

1.5

0.00

g/l

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

7.05

2.45

2.6

1.5

0.00

g/l

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

7.05

2.45

5.0

1.1

13.96

10.51

mg/l

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

7.05

2.45

2.6

1.5

0.00

g/l

—

(3004588) Protein electrophoresis panel - Serum or Plasma

4.58

2.39

2.1

3.4

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

5.32

2.38

3.2

1.2

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

2.84

2.31

7.6

2.3

286.13

120.72

ug/l

0.81

(3000494) Fungus identified in Specimen by Culture

3.37

2.31

3.4

1.5

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

6.26

2.29

2.6

1.4

0.72

0.68

g/l

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

4.33

2.28

33.1

7.1

1.13

1.05

mmol/l

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

278

0.35

2.28

5.4

4.5

4.63

4.48

mmol/l

0.25

259

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.92

2.26

6.5

2.0

—

(3044640) Blood type and Crossmatch panel - Blood

2.77

2.19

5.9

1.9

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

276

0.36

2.15

5.3

4.4

1.30

1.43

mmol/l

0.89

254

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

283

0.36

2.12

6.2

5.2

2.78

2.63

mmol/l

0.25

259

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

4.29

2.03

2.0

1.3

—

(3026493) Urate [Moles/volume] in Serum or Plasma

2.66

1.97

4.7

3.0

367.53

3573.74

umol/l

0.49

(3019832) Treponema pallidum Ab [Presence] in Serum

3.80

1.83

1.2

1.9

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

124

2.43

1.72

5.9

2.2

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.98

1.61

2.6

1.6

—

(3010813) Leukocytes [#/volume] in Blood

308

0.40

1.47

92.2

19.0

6.93

6.52

e9/l

0.47

299

(3011397) Hemoglobin [Presence] in Urine by Test strip

2.46

1.46

3.8

3.6

—

(3024731) MCV [Entitic volume]

307

0.41

1.44

91.9

19.0

92.35

90.92

0.62

302

(3026361) Erythrocytes [#/volume] in Blood

307

0.41

1.44

92.2

19.1

4.14

4.56

e12/l

2.95

298

(3007461) Platelets [#/volume] in Blood

307

0.41

1.44

92.2

19.1

241.27

238.08

e9/l

0.07

299

(3035941) MCH [Entitic mass]

307

0.41

1.44

91.8

19.0

30.30

30.27

0.02

302

(3000963) Hemoglobin [Mass/volume] in Blood

307

0.41

1.44

92.6

19.2

125.19

137.38

g/l

2.61

302

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.25

1.41

29.8

3.9

25.40

25.59

mmol/l

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

124

2.16

1.36

30.6

5.2

1.20

1.21

mmol/l

0.10

112

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

269

0.45

1.34

4.4

3.9

1.48

1.25

mmol/l

1.39

245

(3002256) Pathology report gross observation

2.50

1.32

2.0

1.2

—

(3000492) Spirometry study

2.68

1.30

5.2

1.6

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

139

2.02

1.16

28.8

5.3

10.40

13.51

umol/l

0.56

131

(40758558) Short blood count panel - Blood

2.06

1.11

34.6

6.8

—

(3022096) Basophils/100 leukocytes in Blood

114

1.96

1.07

39.1

5.6

0.55

0.67

0.40

108

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

277

0.51

0.97

6.1

4.6

6.42

5.95

mmol/l

0.58

253

(3021960) Folate [Moles/volume] in Serum or Plasma

1.95

0.93

2.5

1.4

18.70

20.88

nmol/l

0.31

(3022145) Colonoscopy Study observation

2.20

0.92

1.3

1.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

119

1.83

0.90

38.4

6.2

—

(3006504) Eosinophils/100 leukocytes in Blood

119

1.83

0.90

40.1

5.6

2.19

2.72

0.34

113

(3013115) Eosinophils [#/volume] in Blood

129

1.81

0.88

37.1

5.8

0.17

0.19

e9/l

0.14

117

(3019069) Monocytes/100 leukocytes in Blood

121

1.79

0.84

41.2

5.9

10.96

8.62

0.68

115

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

296

0.53

0.83

42.0

9.8

26.58

26.67

u/l

0.01

287

(3020564) Creatinine [Moles/volume] in Serum or Plasma

295

0.54

0.82

71.5

15.2

109.77

82.11

umol/l

0.69

295

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

2.05

0.79

1.4

1.2

—

(3018010) Neutrophils/100 leukocytes in Blood

123

1.74

0.78

36.9

5.7

58.02

58.41

0.04

117

(3019225) pH of Specimen

2.07

0.74

8.6

4.5

—

(3001604) Monocytes [#/volume] in Blood

125

1.70

0.73

35.8

5.7

0.67

0.59

e9/l

0.40

113

(3002030) Lymphocytes/100 leukocytes in Blood

125

1.70

0.73

40.6

5.9

25.39

26.41

0.12

119

(3006315) Basophils [#/volume] in Blood

125

1.70

0.73

35.8

5.8

0.03

0.04

e9/l

1.02

113

(4200892) Spirometry reversibility

1.99

0.71

2.0

1.3

—

(3019309) Folate [Moles/volume] in Red Blood Cells

1.66

0.64

1.9

1.4

581.63

1263.52

nmol/l

—

(3019198) Lymphocytes [#/volume] in Blood

129

1.62

0.62

35.4

6.1

1.48

1.75

e9/l

0.59

119

(3026782) Osmolality of Urine

1.67

0.61

3.0

2.1

527.44

500.57

mosm/kgh2o

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

289

0.61

0.60

81.0

14.4

4.05

4.00

mmol/l

0.36

281

(3019550) Sodium [Moles/volume] in Serum or Plasma

288

0.62

0.59

80.8

14.3

138.81

139.66

mmol/l

1.37

280

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

257

0.61

0.59

8.5

5.3

43.05

40.36

mmol/mol

0.41

235

(40761511) CBC panel - Blood by Automated count

286

0.65

0.57

55.6

12.0

—

(3003694) ABO and Rh group [Type] in Blood

1.69

0.57

1.6

1.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

0.56

0.54

4.0

3.2

—

(3003338) MCHC [Mass/volume]

232

0.68

0.43

90.8

16.5

328.45

332.69

g/l

1.32

232

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

109

1.47

0.42

4.1

2.2

73.19

77.65

nmol/l

0.31

(40768797) Stomach Pathology biopsy report

1.56

0.38

1.2

1.3

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

106

0.68

0.36

4.6

3.8

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

1.42

0.34

5.4

2.8

2.37

2.36

mmol/l

0.20

(40768804) Tissue Pathology biopsy report

115

1.36

0.30

4.6

2.1

—

(3013707) Erythrocyte sedimentation rate by Westergren method

202

0.78

0.23

18.6

4.2

19.06

13.50

mm/h

0.62

188

(3044889) 12 lead EKG panel

202

0.78

0.23

9.1

3.9

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

109

1.31

0.23

7.5

2.8

—

(3015736) pH of Urine

100

1.30

0.22

3.7

3.4

—

5.93

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.22

0.0

1.8

—

298.82

—

(3012501) Base excess in Blood by calculation

0.00

0.22

0.0

1.5

—

3.14

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.22

0.0

1.5

—

8.01

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.22

0.0

1.3

—

(3010421) pH of Blood

0.00

0.22

0.0

1.6

—

7.45

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.22

0.0

1.5

—

4.75

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.21

0.0

1.1

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.21

0.0

1.5

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

76.86

—

(3020961) Endomysium IgA Ab [Titer] in Serum

0.00

0.20

0.0

1.1

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.20

0.0

1.7

—

37.29

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

1.28

0.20

2.4

1.9

427.29

451.85

pmol/l

—

(3037467) Urinalysis macro (dipstick) panel - Urine

191

1.25

0.18

7.8

4.1

—

(3013512) EKG study

0.73

0.18

3.7

4.3

—

(3026008) Bacteria identified in Urine by Culture

1.23

0.12

3.4

2.3

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

124

0.84

0.11

4.1

4.0

22.92

22.43

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

196

1.18

0.11

4.2

3.5

13.81

15.05

pmol/l

1.98

179

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

166

1.17

0.11

3.2

2.6

—

(3030467) Casts [#/volume] in Urine by Automated count

1.19

0.09

9.0

2.6

0.21

0.43

e6/l

—

(3000850) Epithelial cells [#/volume] in Urine

1.14

0.08

3.1

2.2

1.25

4.41

e6/l

—

(3002582) Erythrocytes [#/volume] in Urine

102

1.11

0.03

8.6

2.6

10.50

647.37

e6/l

0.54

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

214

1.08

0.01

38.1

6.6

104.18

75.48

u/l

0.68

206

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

177

1.03

0.00

6.4

2.5

104.17

52.46

u/l

0.74

168

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.0

2.9

—

59.50

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

1.4

—

87.06

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.2

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.0

2.9

—

4.39

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.0

3.4

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.0

1.1

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.0

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.0

1.0

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(3027008) Opiates [Presence] in Urine

0.00

0.0

1.1

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.0

1.6

—

1.48

—

(4281824) Cell count and differential, peritoneal fluid

0.00

0.0

1.0

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.0

1.8

—

2.58

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.0

1.0

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.0

1.0

—

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

67.68

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.0

1.3

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.4

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

3.5

—

20.88

—

(3009214) Lutropin [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

4.80

—

(1616796) Gas panel - Central venous blood

0.00

-0.00

0.0

2.6

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3018095) Leukocytes [#/volume] in Urine

110

1.00

-0.00

10.6

3.2

5.69

111.16

e6/l

1.82

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.5

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

-0.00

0.0

1.0

—

(36304419) Bacteria [Presence] in Urine

1.02

-0.00

9.9

2.4

—

(3016879) Cocaine [Presence] in Urine

0.00

-0.00

0.0

1.1

—

(3031040) Bacteria [#/volume] in Urine by Automated count

190

1.00

-0.00

9.6

4.0

—

104.50

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_NOCARDIOSIS and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
AB1_NOCARDIOSIS	3.248 [1.86, 5.68]	< 0.001
Birth year	0.983 [0.97, 0.99]	< 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 117 males with AB1_NOCARDIOSIS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_NOCARDIOSIS.

N-year risk	Females	Males
1	No data	0.523%
5	No data	3.446%
10	No data	8.776%
15	No data	15.743%
20	No data	25.32%

Relationships between endpoints

↥

Index endpoint: AB1_NOCARDIOSIS – Nocardiosis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	AB1_NOCARDIOSIS
CONTROL_EXCLUDE	AB1_OTHER_BACTERIAL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	A43
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	A43
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Nocardiosis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints