Rickettsioses

AB1_RICKETTSIOSES

spotted fever: a type of tick-borne disease which presents on the skin caused by bacteria of the genus Rickettsia.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — A75-A79 Hospital discharge: ICD-9 — 08[2-3] Hospital discharge: ICD-8 — 08[0-3] Cause of death: ICD-10 — A75-A79 Cause of death: ICD-9 — 08[2-3] Cause of death: ICD-8 — 08[0-3] 2 out of 7 registries used, show all original rules.	-
4. Check minimum number of events None	-
5. Include endpoints AB1_TYPHUS_FEVER AB1_SPOTTED_FEVER AB1_Q_FEVER AB1_OTHER_RICEKTTSIOSES	63
6. Filter based on genotype QC (FinnGen only)	63

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 2
First used in FinnGen datafreeze: DF2

NAME	AB1_RICKETTSIOSES
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	AB1_TYPHUS_FEVER\|AB1_SPOTTED_FEVER\|AB1_Q_FEVER\|AB1_OTHER_RICEKTTSIOSES
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	A7[5-9]
HD_ICD_9	08[2-3]
HD_ICD_8	08[0-3]
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	A7[5-9]
COD_ICD_9	08[2-3]
COD_ICD_8	08[0-3]
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Rickettsioses based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	591	237	350
Only index persons	501	200	301
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	44.51	45.50	43.80
Only index persons	42.27	44.06	41.09

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	63	26	37
Unadjusted period prevalence (%)	0.01	0.01	0.02
Median age at first event (years)	49.93	44.78	53.55

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
57: Matched controls
568

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

A78

ICD-10 Finland

Q fever

+∞

11.9

R50.9

ICD-10 Finland

Fever, unspecified

6.3

7.4

A77.9

ICD-10 Finland

Spotted fever, unspecified

+∞

6.4

A79.9

ICD-10 Finland

Rickettsiosis, unspecified

+∞

6.4

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3019768) Coxiella burnetii Ab [Presence] in Serum

+∞

6.35

4.3

0.0

—

(3052851) Hemolysis interference index of Serum or Plasma

6.36

3.81

3.7

4.1

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

2.82

3.37

1.8

1.7

0.73

0.99

mg/l

0.44

(3018095) Leukocytes [#/volume] in Urine

184

2.50

3.15

5.9

3.6

14.43

83.73

e6/l

0.73

142

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

2.77

3.09

4.3

2.5

0.72

2.21

e6/l

0.63

(3003458) Phosphate [Moles/volume] in Serum or Plasma

2.86

2.79

7.5

7.0

1.02

1.07

mmol/l

0.40

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.56

2.75

2.0

1.7

—

(3000991) Gas panel - Venous blood

3.12

2.52

16.5

6.3

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

2.46

2.49

5.3

3.6

752.36

38.90

ng/l

0.48

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.57

2.42

14.4

6.8

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

178

2.17

2.29

2.1

1.9

112.34

95.08

pmol/l

0.92

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

2.37

2.23

4.3

2.4

0.77

0.63

e6/l

0.19

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

4.01

2.22

1.1

2.0

35.66

107.95

u/ml

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

3.80

2.12

2.6

2.8

0.53

0.78

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

3.37

2.09

2.8

4.4

139.38

130.92

g/l

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.37

2.09

3.4

1.4

—

(3023368) Bacteria identified in Blood by Culture

134

2.13

2.03

6.6

4.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

186

2.04

1.98

4.9

3.1

—

(3042936) Bacteria identified in Isolate by Culture

2.35

1.94

1.7

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.78

1.94

1.5

1.4

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

3.44

1.94

2.6

2.7

1.79

1.64

—

(40758558) Short blood count panel - Blood

120

2.13

1.93

7.9

7.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

105

2.16

1.90

2.8

3.8

—

(3002032) Base excess in Venous blood by calculation

2.64

1.78

6.6

4.3

1.94

2.11

mmol/l

—

(3021589) Normoblasts [#/volume] in Blood

220

1.92

1.74

13.0

9.8

0.00

e9/l

0.00

187

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.80

1.73

13.6

7.0

1.10

1.36

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.80

1.73

16.8

7.0

0.59

0.61

—

(3012544) pH of Venous blood

2.58

1.70

6.7

4.2

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

2.12

1.56

1.8

1.3

16.09

43.80

iu/ml

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

3.52

1.55

1.2

1.3

1.49

1.05

g/l

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

3.52

1.55

1.2

1.3

0.32

0.19

g/l

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

3.52

1.55

1.2

1.4

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

2.40

1.49

1.8

1.6

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

2.90

1.47

3.7

3.5

36.58

46.17

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

3.30

1.46

1.2

1.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.26

1.43

2.5

1.7

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

213

1.78

1.40

3.7

2.6

166.85

124.52

ug/l

0.51

198

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

214

1.77

1.37

3.4

4.1

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

2.22

1.33

3.6

3.3

29.67

32.34

u/l

—

(3032080) INR in Blood by Coagulation assay

216

1.74

1.31

4.1

9.1

1.22

1.25

inr

—

(3008898) HLA-B27 [Presence]

2.92

1.31

1.0

1.1

—

(3021601) Nitrite [Presence] in Urine by Test strip

247

1.71

1.24

4.6

0.00

estimate

—

(36304419) Bacteria [Presence] in Urine

148

1.75

1.20

5.7

2.8

—

(3009261) Glucose [Presence] in Urine by Test strip

250

1.67

1.16

2.8

3.5

0.00

estimate

—

(42870588) Differential panel, method unspecified - Blood

158

1.72

1.16

7.5

6.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

2.10

1.13

2.1

1.6

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

125

1.74

1.11

3.3

2.9

0.64

0.71

ug/l

0.29

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

1.90

1.09

1.5

1.3

6.33

16.90

u/ml

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.06

1.08

2.0

3.6

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.38

1.05

1.4

1.3

—

(3022313) Gas panel - Capillary blood

2.38

1.05

1.2

3.8

—

(3002256) Pathology report gross observation

1.93

1.02

1.3

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

2.00

0.97

3.7

157.86

185.95

ng/l

—

(3035350) Ketones [Presence] in Urine by Test strip

249

1.58

0.96

2.9

3.4

0.00

estimate

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.93

0.94

2.7

1.8

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

290

1.56

0.92

3.4

3.2

—

(3020630) Protein [Mass/volume] in Serum or Plasma

1.93

0.90

1.5

2.1

64.95

66.31

g/l

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.77

0.85

2.3

2.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.81

0.85

1.7

1.5

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

170

1.56

0.84

3.4

4.7

20.83

21.10

0.03

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

208

1.52

0.82

3.1

4.0

20.26

24.39

ng/l

0.47

148

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.69

0.79

1.7

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

101

1.64

0.79

2.1

2.4

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.17

0.76

1.2

1.8

—

(3019198) Lymphocytes [#/volume] in Blood

249

1.48

0.76

10.9

6.4

1.67

1.74

e9/l

0.26

231

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.08

0.74

3.2

6.2

23.20

24.20

mmol/l

—

(3001604) Monocytes [#/volume] in Blood

241

1.47

0.73

10.9

6.2

0.60

e9/l

0.03

219

(3031040) Bacteria [#/volume] in Urine by Automated count

320

1.47

0.72

5.2

4.2

—

180.75

—

(3006315) Basophils [#/volume] in Blood

242

1.46

0.71

11.0

6.2

0.04

e9/l

0.22

220

(3022096) Basophils/100 leukocytes in Blood

224

1.45

0.68

11.2

6.5

0.81

0.66

0.92

211

(3037467) Urinalysis macro (dipstick) panel - Urine

344

1.45

0.65

5.2

4.2

—

(3003694) ABO and Rh group [Type] in Blood

124

1.51

0.64

1.6

1.4

—

(3013115) Eosinophils [#/volume] in Blood

246

1.42

0.63

11.3

6.8

0.17

0.19

e9/l

0.47

226

(3000494) Fungus identified in Specimen by Culture

1.67

0.63

1.3

1.4

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.72

0.63

2.2

3.0

0.00

0.12

e6/l

—

(40761535) Cells panel - Urine sediment

1.84

0.60

1.5

3.7

—

(3002030) Lymphocytes/100 leukocytes in Blood

239

1.40

0.58

11.3

6.5

29.71

26.82

0.81

226

(3004588) Protein electrophoresis panel - Serum or Plasma

1.69

0.57

1.3

1.4

—

(3006504) Eosinophils/100 leukocytes in Blood

230

1.39

0.57

11.4

6.5

2.93

2.65

0.30

217

(3019060) Gas panel - Arterial blood

1.59

0.54

3.0

4.6

—

(3019069) Monocytes/100 leukocytes in Blood

233

1.36

0.52

11.6

7.0

10.02

8.57

1.39

222

(3044889) 12 lead EKG panel

363

1.37

0.51

4.2

4.0

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.59

0.50

1.6

—

(3044640) Blood type and Crossmatch panel - Blood

140

1.40

0.49

2.7

2.5

—

(3018010) Neutrophils/100 leukocytes in Blood

235

1.34

0.48

11.5

6.4

54.53

58.41

0.88

223

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.48

0.48

1.1

1.3

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

0.00

0.42

0.0

2.0

—

2.68

—

(3037121) Protein [Mass/volume] in Urine

0.00

0.41

0.0

4.5

—

0.22

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.41

0.0

1.4

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.40

0.0

1.5

—

6.26

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

173

1.32

0.40

1.9

2.7

49.52

58.98

u/l

1.10

161

(3009542) Hematocrit [Volume Fraction] of Blood

454

1.36

0.39

27.4

15.7

39.32

40.22

0.32

344

(40768804) Tissue Pathology biopsy report

193

1.30

0.38

1.9

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

1.40

0.35

1.7

2.6

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

206

1.27

0.33

2.1

3.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.33

0.32

1.7

—

(3022145) Colonoscopy Study observation

1.31

0.31

1.9

1.2

—

(3048689) Calprotectin [Mass/mass] in Stool

1.31

0.31

2.9

1.3

86.67

70.11

ug/g

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.36

0.30

3.0

2.0

370.63

364.70

nmol/l

—

(3026008) Bacteria identified in Urine by Culture

133

1.27

0.28

3.6

2.6

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

291

1.20

0.24

12.0

10.9

3.54

4.15

e9/l

1.32

262

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.34

0.24

1.6

1.8

—

(3017732) Neutrophils [#/volume] in Blood

1.24

0.22

4.8

3.8

4.10

3.90

e9/l

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.2

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.21

0.0

2.1

—

(40768793) Breast Pathology biopsy report

0.00

0.21

0.0

1.3

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.21

0.0

3.5

—

(1616796) Gas panel - Central venous blood

0.00

0.21

0.0

3.6

—

(3020148) Glutamate decarboxylase 65 Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.21

0.0

3.8

—

4.87

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.21

0.0

3.8

—

8.13

—

(3012501) Base excess in Blood by calculation

0.00

0.21

0.0

3.8

—

3.09

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.21

0.0

1.2

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.20

0.0

1.2

—

(3029937) Albumin [Presence] in Urine by Test strip

148

1.20

0.19

1.9

3.6

0.00

estimate

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.26

0.19

1.6

1.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.71

0.18

1.4

1.2

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

526

1.19

0.14

26.7

17.4

103.22

81.02

umol/l

0.57

526

(40761511) CBC panel - Blood by Automated count

526

1.19

0.14

15.0

14.7

—

(3041096) Erythrocytes [Presence] in Urine by Automated

153

1.15

0.13

2.3

2.8

—

(3013512) EKG study

144

1.15

0.12

4.1

3.9

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.19

0.11

1.4

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

1.10

0.09

1.5

4.7

1.88

132.58

ug/l

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.12

0.08

1.6

—

(40768797) Stomach Pathology biopsy report

0.79

0.08

1.2

1.3

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

511

1.10

0.04

23.6

14.2

30.19

22.62

mg/l

0.51

397

(3019550) Sodium [Moles/volume] in Serum or Plasma

512

1.09

0.03

27.8

16.7

139.50

139.78

mmol/l

0.32

499

(1761868) Lipid panel - Serum or Plasma

202

1.06

0.02

2.6

2.7

—

(40760892) CBC W Ordered Manual Differential panel - Blood

113

0.97

0.00

6.5

5.5

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

516

1.04

0.00

28.2

16.7

3.97

3.98

mmol/l

0.06

502

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

2.8

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.2

—

(3000963) Hemoglobin [Mass/volume] in Blood

561

0.98

0.00

30.8

21.7

134.39

135.20

g/l

0.15

555

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.2

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

1.3

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

2.8

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.5

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

4.0

—

126.83

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.2

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

0.0

1.3

—

8.83

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.1

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

2.1

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

1.6

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

3.2

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(3010813) Leukocytes [#/volume] in Blood

560

1.00

0.00

30.5

21.7

6.65

6.73

e9/l

0.10

551

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

3.3

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.0

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.8

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

1.6

—

88.48

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

3.1

—

3.02

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3024731) MCV [Entitic volume]

560

1.00

0.00

30.6

21.5

91.26

91.36

0.07

555

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.0

1.6

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

3.2

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

3.0

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

3.2

—

(3044941) Cell count panel - Synovial fluid

0.00

0.0

1.4

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.92

0.00

5.6

7.9

—

(3026361) Erythrocytes [#/volume] in Blood

560

1.00

0.00

30.6

21.6

4.49

4.46

e12/l

0.16

549

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

15.17

—

(4281824)

0.00

0.0

1.0

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

9.4

—

765.20

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

0.0

1.2

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.6

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.6

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

12.4

—

1435.20

—

(3026285) Alpha 1 antitrypsin [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

1.41

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.4

—

162.88

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.4

—

(3007461) Platelets [#/volume] in Blood

559

1.02

0.00

30.5

21.7

242.88

248.97

e9/l

0.30

550

(40768806) Pleura Pathology biopsy report

0.00

0.0

2.0

—

(3020491) Glucose [Moles/volume] in Blood

0.00

0.0

1.2

—

6.24

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.0

2.0

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.3

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.4

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

3.2

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.2

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.4

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_RICKETTSIOSES and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have AB1_RICKETTSIOSES.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: AB1_RICKETTSIOSES – Rickettsioses

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Rickettsioses

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints