Rickettsioses

AB1_RICKETTSIOSES

spotted fever: a type of tick-borne disease which presents on the skin caused by bacteria of the genus Rickettsia.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — A75-A79 Hospital discharge: ICD-9 — 08[2-3] Hospital discharge: ICD-8 — 08[0-3] Cause of death: ICD-10 — A75-A79 Cause of death: ICD-9 — 08[2-3] Cause of death: ICD-8 — 08[0-3] 2 out of 7 registries used, show all original rules.	-
4. Check minimum number of events None	-
5. Include endpoints AB1_TYPHUS_FEVER AB1_SPOTTED_FEVER AB1_Q_FEVER AB1_OTHER_RICEKTTSIOSES	66
6. Filter based on genotype QC (FinnGen only)	64

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 2
First used in FinnGen datafreeze: DF2

NAME	AB1_RICKETTSIOSES
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	AB1_TYPHUS_FEVER\|AB1_SPOTTED_FEVER\|AB1_Q_FEVER\|AB1_OTHER_RICEKTTSIOSES
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	A7[5-9]
HD_ICD_9	08[2-3]
HD_ICD_8	08[0-3]
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	A7[5-9]
COD_ICD_9	08[2-3]
COD_ICD_8	08[0-3]
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Rickettsioses based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	591	237	350
Only index persons	501	200	301
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	44.51	45.50	43.80
Only index persons	42.27	44.06	41.09

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	64	28	36
Unadjusted period prevalence (%)	0.01	0.01	0.02
Median age at first event (years)	51.50	48.01	54.22

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
66: Matched controls
660

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

A78

ICD-10 Finland

Q fever

+∞

12.9

A79.9

ICD-10 Finland

Rickettsiosis, unspecified

+∞

8.5

R50.9

ICD-10 Finland

Fever, unspecified

4.2

6.5

A77.9

ICD-10 Finland

Spotted fever, unspecified

+∞

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3019768) Coxiella burnetii Ab [Presence] in Serum

+∞

6.34

4.3

0.0

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

3.64

4.82

7.1

6.4

104.42

104.00

mmol/l

0.16

(3052851) Hemolysis interference index of Serum or Plasma

5.94

3.65

3.4

3.8

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

2.87

3.63

1.8

1.7

1.10

0.98

mg/l

0.10

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

2.94

3.59

4.2

2.5

0.66

2.21

e6/l

0.66

(3018095) Leukocytes [#/volume] in Urine

188

2.51

3.30

5.8

3.6

13.86

82.32

e6/l

0.74

145

(3003458) Phosphate [Moles/volume] in Serum or Plasma

3.03

3.25

7.6

6.9

1.03

1.07

mmol/l

0.35

(46235355) HIV 1 and 2 tests - Meaningful Use set

100

2.61

3.00

2.0

1.7

—

(3000991) Gas panel - Venous blood

3.26

2.73

15.5

6.2

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

2.53

2.66

4.2

2.4

0.71

0.63

e6/l

0.11

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.61

2.65

13.1

7.2

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

2.46

2.61

5.3

3.8

712.13

42.65

ng/l

0.49

(3021879) Hepatitis B virus core Ab [Presence] in Serum

3.01

2.34

1.5

1.4

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

5.90

2.25

1.2

1.1

—

(3023368) Bacteria identified in Blood by Culture

137

2.18

2.23

6.9

4.5

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

3.99

2.22

1.1

2.0

35.66

107.95

u/ml

—

(3002032) Base excess in Venous blood by calculation

2.86

2.21

6.4

4.2

2.05

2.11

mmol/l

0.02

(3042936) Bacteria identified in Isolate by Culture

2.42

2.19

1.8

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

189

2.08

2.16

2.1

1.9

112.34

95.29

pmol/l

0.91

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

4.29

2.09

1.2

1.3

1.24

1.05

g/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

191

2.05

2.08

4.7

3.1

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

3.60

2.03

2.6

2.7

0.53

0.76

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.23

2.01

3.4

1.4

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

3.23

2.01

2.8

4.3

139.38

128.78

g/l

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

4.82

1.98

1.0

2.8

194.60

186.00

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

4.82

1.98

1.2

1.9

78.40

91.82

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

3.28

1.85

2.6

2.7

1.79

1.63

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

227

1.91

1.77

3.7

2.6

159.58

121.15

ug/l

0.51

212

(40758558) Short blood count panel - Blood

127

1.96

1.62

7.9

7.4

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.62

1.60

13.6

7.5

1.10

1.40

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.62

1.60

16.8

7.5

0.59

0.64

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

112

1.98

1.57

2.8

3.7

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

3.51

1.55

1.2

1.3

0.32

0.19

g/l

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

3.51

1.55

1.4

1.1

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

2.38

1.48

3.4

3.2

30.30

32.19

u/l

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

3.29

1.46

1.2

1.4

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

2.00

1.45

1.8

1.3

16.09

40.83

iu/ml

—

(3021601) Nitrite [Presence] in Urine by Test strip

258

1.76

1.41

4.7

4.6

0.00

estimate

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

2.76

1.40

3.7

3.3

36.58

46.31

—

(3021589) Normoblasts [#/volume] in Blood

231

1.75

1.38

13.0

9.6

0.00

e9/l

-0.00

196

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

3.09

1.38

1.2

1.9

—

(36304419) Bacteria [Presence] in Urine

151

1.80

1.36

5.6

2.7

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.28

1.36

2.0

3.5

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

2.28

1.36

1.8

1.6

—

(3009261) Glucose [Presence] in Urine by Test strip

261

1.73

1.34

3.0

3.5

0.00

estimate

—

(3020630) Protein [Mass/volume] in Serum or Plasma

2.21

1.33

1.6

2.1

63.07

66.31

g/l

—

(3003327) Ova and parasites identified in Stool by Light microscopy

2.92

1.31

2.2

1.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.12

1.25

2.5

2.0

—

(3002256) Pathology report gross observation

2.18

1.24

1.3

—

(3020682) Albumin/Creatinine [Ratio] in Urine

156

1.73

1.21

4.3

3.7

3.95

12.48

mg/mmol

1.29

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

231

1.64

1.14

2.5

2.7

—

(3035350) Ketones [Presence] in Urine by Test strip

260

1.63

1.13

3.1

3.5

0.00

estimate

—

(3022217) INR in Platelet poor plasma by Coagulation assay

261

1.62

1.10

8.6

14.0

1.29

1.26

inr

0.07

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

125

1.73

1.10

3.3

2.9

0.64

0.71

ug/l

0.29

(3022313) Gas panel - Capillary blood

2.37

1.05

1.2

3.8

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.37

1.05

1.4

1.3

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

2.00

1.03

2.1

1.6

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.87

1.00

1.8

1.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.77

0.97

1.7

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

105

1.69

0.92

2.1

2.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

309

1.54

0.91

3.3

3.2

—

(3031040) Bacteria [#/volume] in Urine by Automated count

332

1.52

0.85

5.2

4.1

—

180.75

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

170

1.54

0.83

3.4

4.7

20.83

21.10

0.03

(3012516) Albumin [Mass/volume] in Urine

152

1.56

0.83

3.2

30.91

483.33

mg/l

0.58

101

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.82

0.81

2.7

2.0

—

(3008898) HLA-B27 [Presence]

2.27

0.78

1.0

1.1

—

(3000494) Fungus identified in Specimen by Culture

1.74

0.77

1.3

1.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

238

1.48

0.77

8.4

7.2

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.94

0.76

3.7

4.1

157.86

180.95

ng/l

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.17

0.76

1.2

1.8

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

1.66

0.76

1.5

1.3

6.33

14.93

u/ml

—

(3006315) Basophils [#/volume] in Blood

258

1.47

0.76

10.4

6.2

0.04

e9/l

0.07

236

(3001604) Monocytes [#/volume] in Blood

258

1.47

0.76

10.3

6.1

0.59

e9/l

0.04

236

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

220

1.47

0.75

3.1

3.9

19.47

24.17

ng/l

0.57

151

(3019198) Lymphocytes [#/volume] in Blood

268

1.46

0.75

10.4

6.3

1.59

1.76

e9/l

0.71

250

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.68

0.75

2.3

2.2

—

(3022096) Basophils/100 leukocytes in Blood

240

1.46

0.73

10.5

6.4

0.79

0.67

0.71

226

(3037467) Urinalysis macro (dipstick) panel - Urine

359

1.47

0.72

5.2

4.1

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.00

0.72

3.2

6.0

23.20

24.20

mmol/l

—

(3019060) Gas panel - Arterial blood

1.74

0.71

2.7

5.4

—

(3003694) ABO and Rh group [Type] in Blood

131

1.51

0.69

1.6

1.4

—

(3013115) Eosinophils [#/volume] in Blood

264

1.41

0.64

10.7

6.7

0.16

0.19

e9/l

0.85

244

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.65

0.63

1.1

1.3

—

(3002030) Lymphocytes/100 leukocytes in Blood

256

1.40

0.61

10.7

6.4

29.52

27.42

0.57

244

(3006504) Eosinophils/100 leukocytes in Blood

247

1.39

0.60

10.8

6.4

2.84

2.70

0.15

234

(40768804) Tissue Pathology biopsy report

200

1.40

0.59

1.9

1.8

—

(40761535) Cells panel - Urine sediment

1.73

0.58

1.5

3.8

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

182

1.40

0.57

2.9

2.8

47.96

58.56

u/l

1.40

169

(3004588) Protein electrophoresis panel - Serum or Plasma

1.68

0.57

1.3

1.4

—

(3044640) Blood type and Crossmatch panel - Blood

146

1.42

0.55

2.8

2.5

—

(3019069) Monocytes/100 leukocytes in Blood

250

1.37

0.55

11.1

6.9

10.07

8.53

1.63

239

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.55

0.53

1.7

1.8

—

(3018010) Neutrophils/100 leukocytes in Blood

252

1.35

0.51

10.8

6.3

54.87

58.00

0.70

240

(3026008) Bacteria identified in Urine by Culture

139

1.41

0.51

3.4

2.5

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.55

0.49

1.6

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

215

1.35

0.49

2.3

3.4

—

(3044889) 12 lead EKG panel

384

1.34

0.48

4.3

4.0

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.66

0.44

2.2

2.9

0.00

0.12

e6/l

—

(3037121) Protein [Mass/volume] in Urine

0.00

0.41

0.0

4.5

—

0.22

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

0.00

0.41

0.0

1.9

—

5.30

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.41

0.0

1.3

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.40

0.0

1.5

—

6.26

—

(3029937) Albumin [Presence] in Urine by Test strip

156

1.31

0.36

2.4

3.6

0.00

estimate

—

(3041096) Erythrocytes [Presence] in Urine by Automated

158

1.28

0.33

2.6

2.9

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.33

0.29

3.0

2.0

370.63

370.11

nmol/l

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

308

1.21

0.27

11.5

10.7

3.43

4.09

e9/l

1.56

279

(3000492) Spirometry study

1.30

0.23

1.4

1.5

—

(36660697) Celiac disease serology panel - Serum

1.21

0.22

1.2

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.2

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.21

0.0

3.5

—

(3020148) Glutamate decarboxylase 65 Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(1616796) Gas panel - Central venous blood

0.00

0.21

0.0

3.6

—

(40768793) Breast Pathology biopsy report

0.00

0.21

0.0

1.2

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.21

0.0

3.7

—

4.87

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.21

0.0

3.7

—

8.13

—

(3012501) Base excess in Blood by calculation

0.00

0.21

0.0

3.7

—

3.09

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.21

0.0

1.2

—

(3048689) Calprotectin [Mass/mass] in Stool

1.25

0.19

2.9

1.3

86.67

73.91

ug/g

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.23

0.19

1.4

1.7

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

1.23

0.19

1.6

4.6

1.79

124.59

ug/l

—

(3022145) Colonoscopy Study observation

1.16

0.18

1.9

1.1

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.14

0.18

1.6

1.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.78

0.16

1.3

1.2

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

555

1.20

0.14

27.4

17.2

101.60

80.27

umol/l

0.58

555

(3005719) IgG [Mass/volume] in Serum or Plasma

1.18

0.10

2.4

2.3

8.53

9.50

g/l

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

537

1.15

0.09

24.4

14.2

29.30

22.10

mg/l

0.51

416

(3007853) Bacteria identified in Skin by Aerobe culture

1.10

0.08

1.6

—

(3013512) EKG study

149

1.10

0.06

4.1

3.8

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

540

1.11

0.05

28.0

16.6

139.33

139.80

mmol/l

0.62

527

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.08

0.01

1.4

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

544

1.07

0.01

28.4

16.6

3.97

3.98

mmol/l

0.05

530

(40761511) CBC panel - Blood by Automated count

555

1.06

0.00

16.9

14.6

—

(1761868) Lipid panel - Serum or Plasma

214

0.97

0.00

2.6

2.7

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

15.18

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

12.4

—

1435.20

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.3

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

0.0

1.2

—

8.22

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.0

2.0

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.0

1.4

—

(4281824) Cell count and differential, peritoneal fluid

0.00

0.0

1.0

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.1

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.8

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.2

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

1.2

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

3.1

—

3.03

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(3002079) Sodium [Moles/time] in 24 hour Urine

0.00

0.0

1.0

—

177.00

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.3

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

1.6

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

9.4

—

765.20

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.0

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.6

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.6

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

3.0

—

(3044941) Cell count panel - Synovial fluid

0.00

0.0

1.4

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.8

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

3.3

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

-0.00

0.0

1.6

—

88.48

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

297.57

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.2

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.4

—

(3024731) MCV [Entitic volume]

589

1.02

-0.00

31.5

21.3

91.28

91.31

0.02

584

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

2.1

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

3.2

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.4

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

-0.00

0.0

1.3

—

(3000963) Hemoglobin [Mass/volume] in Blood

590

1.00

-0.00

31.8

21.5

133.76

135.20

g/l

0.31

584

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.4

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

-0.00

0.0

1.2

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.2

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

4.0

—

126.83

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(40768797) Stomach Pathology biopsy report

0.90

-0.00

1.4

1.3

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.8

—

(3010813) Leukocytes [#/volume] in Blood

589

1.02

-0.00

31.5

21.5

6.50

6.71

e9/l

0.30

580

(3007461) Platelets [#/volume] in Blood

588

1.03

-0.00

31.4

21.5

239.76

249.93

e9/l

0.57

579

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.84

-0.00

5.6

7.9

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

-0.00

0.0

2.6

—

(3026361) Erythrocytes [#/volume] in Blood

589

1.02

-0.00

31.6

21.4

4.47

e12/l

0.02

578

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.8

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.6

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.8

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

3.2

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.2

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

-0.00

0.0

1.6

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_RICKETTSIOSES and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have AB1_RICKETTSIOSES.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: AB1_RICKETTSIOSES – Rickettsioses

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Rickettsioses

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints