No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
102 |
4. Check minimum number of eventsNone |
102 |
5. Include endpointsNone |
102 |
6. Filter based on genotype QC (FinnGen only) |
102 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E27
- Name in latin
- Hyperfunctio medullae glandulae suprarenalis
Similar endpoints
↥List of similar endpoints to
Adrenomedullary hyperfunction
based on the number of shared cases.
Similar with more cases:
- Other disorders of adrenal gland
- Exclusions for E4_PCOS_BROAD
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 589 | 326 | 256 |
| Only index persons | 521 | 296 | 225 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 57.31 | 57.45 | 57.21 |
| Only index persons | 56.12 | 56.57 | 55.53 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 102 | 55 | 47 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 53.08 | 50.41 | 56.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 91
- Matched controls
- 907
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E27.5
ICD-10 Finland
Adrenomedullary hyperfunction
+∞
116.2
85
*
D44.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Adrenal gland
+∞
65.8
55
*
BCA31
NOMESCO Finland
Endoscopic unilateral adrenalectomy
+∞
63.0
53
*
D35.0
ICD-10 Finland
Benign neoplasm: Adrenal gland
174.1
46.0
45
5
8700/3-C74.9
ICD-O-3
Pheochromocytoma, NOS, of adrenal gland, NOS
+∞
24.0
22
*
C74.1
ICD-10 Finland
Malignant neoplasm: Medulla of adrenal gland
252.7
20.4
20
*
H02AB09
ATC
hydrocortisone; systemic
252.7
20.4
20
*
C74.9
ICD-10 Finland
Malignant neoplasm: Adrenal gland, unspecified
+∞
19.5
18
*
BCA30
NOMESCO Finland
Unilateral adrenalectomy
+∞
19.5
18
*
C74.0
ICD-10 Finland
Malignant neoplasm: Cortex of adrenal gland
+∞
15.0
14
*
BC1CD
NOMESCO Finland
Very extensive CT of adrenal glands
+∞
15.0
14
*
8700/3-C74.1
ICD-O-3
Pheochromocytoma, NOS, of medulla of adrenal gland
+∞
13.9
13
*
ZXE10
NOMESCO Finland
More than one and less than three hours
5.5
13.2
58
219
TPH07
NOMESCO Finland
Cathetrisation of artery
8.4
12.8
30
50
BC5AQ
NOMESCO Finland
Chromaffine tissue SPECT with low dose CT
+∞
10.6
10
*
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
+∞
8.5
8
*
C04AX02
ATC
phenoxybenzamine; oral
+∞
8.5
8
*
D35.59
ICD-10 Finland
Other paragangliom
+∞
7.4
7
*
105
Kela drug reimbursment
Adrenal cortical hypofunction
+∞
7.4
7
*
JN4BD
NOMESCO Finland
Extensive body CT
5.7
7.0
20
43
JN3BD
NOMESCO Finland
Extensive abdominal CT
5.2
6.2
19
44
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
8.2
6.2
13
18
Mortality – FinRegistry
↥Association
Association between endpoint E4_ADREMEDHYPER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ADREMEDHYPER | 2.134 [1.49, 3.05] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.122 |
During the follow-up period (1.1.1998 — 31.12.2019), 66 out of 254 females with E4_ADREMEDHYPER died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_ADREMEDHYPER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.217% | No data |
| 5 | 1.264% | No data |
| 10 | 2.879% | No data |
| 15 | 5.587% | No data |
| 20 | 9.629% | No data |
Relationships between endpoints
↥Index endpoint: E4_ADREMEDHYPER – Adrenomedullary hyperfunction
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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