Adrenomedullary hyperfunction

E4_ADREMEDHYPER

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E27.5 Hospital discharge: ICD-9 — 2556 Cause of death: ICD-10 — E27.5 Cause of death: ICD-9 — 2556 2 out of 7 registries used, show all original rules.	102
4. Check minimum number of events None	102
5. Include endpoints None	102
6. Filter based on genotype QC (FinnGen only)	102

Control definitions (FinnGen only)

Control exclude: E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E27
Name in latin: Hyperfunctio medullae glandulae suprarenalis

NAME	E4_ADREMEDHYPER
CONTROL_EXCLUDE	E4_ENDOGLAND
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E275
HD_ICD_9	2556
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E275
COD_ICD_9	2556
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Adrenomedullary hyperfunction based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	589	326	256
Only index persons	521	296	225
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	57.31	57.45	57.21
Only index persons	56.12	56.57	55.53

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	102	55	47
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	53.08	50.41	56.20

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
91: Matched controls
907

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

E27.5

ICD-10 Finland

Adrenomedullary hyperfunction

+∞

116.2

D44.1

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Adrenal gland

+∞

65.8

BCA31

NOMESCO Finland

Endoscopic unilateral adrenalectomy

+∞

63.0

D35.0

ICD-10 Finland

Benign neoplasm: Adrenal gland

174.1

46.0

8700/3-C74.9

ICD-O-3

Pheochromocytoma, NOS, of adrenal gland, NOS

+∞

24.0

C74.1

ICD-10 Finland

Malignant neoplasm: Medulla of adrenal gland

252.7

20.4

H02AB09

ATC

hydrocortisone; systemic

252.7

20.4

BCA30

NOMESCO Finland

Unilateral adrenalectomy

+∞

19.5

C74.9

ICD-10 Finland

Malignant neoplasm: Adrenal gland, unspecified

+∞

19.5

BC1CD

NOMESCO Finland

Very extensive CT of adrenal glands

+∞

15.0

C74.0

ICD-10 Finland

Malignant neoplasm: Cortex of adrenal gland

+∞

15.0

8700/3-C74.1

ICD-O-3

Pheochromocytoma, NOS, of medulla of adrenal gland

+∞

13.9

TPH07

NOMESCO Finland

Cathetrisation of artery

8.4

12.8

BC5AQ

NOMESCO Finland

Chromaffine tissue SPECT with low dose CT

+∞

10.6

E34.9

ICD-10 Finland

Endocrine disorder, unspecified

+∞

8.5

C04AX02

ATC

phenoxybenzamine; oral

+∞

8.5

D35.59

ICD-10 Finland

Other paragangliom

+∞

7.4

105

Kela drug reimbursment

Adrenal cortical hypofunction

+∞

7.4

JN4BD

NOMESCO Finland

Extensive body CT

5.7

7.0

JN3BD

NOMESCO Finland

Extensive abdominal CT

5.2

6.2

WZC20

NOMESCO Finland

Multidisciplinary treatment meeting

8.2

6.2

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

124.98

113.15

6.3

1.1

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

115.25

111.37

6.3

1.2

0.6

—

nmol/l

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

122.96

105.08

5.9

1.1

—

nmol/l

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

64.21

71.37

5.6

3.3

6.9

3.8

nmol/l

0.50

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

40.69

20.41

1.2

1.3

—

(4035726)

6.67

18.57

1.3

1.2

—

(3035637) Corticotropin [Mass/volume] in Plasma

32.45

17.85

1.9

1.4

—

(3018418) pH of Serum or Plasma

238

3.55

9.17

6.7

4.7

7.4

0.47

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

9.97

8.22

1.8

12.7

15.5

ug/l

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

4.55

7.71

7.2

4.2

1.2

mmol/l

0.45

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

378

2.98

6.58

8.7

7.5

1.2

mmol/l

0.44

322

(3021589) Normoblasts [#/volume] in Blood

381

2.50

4.80

15.0

9.1

0.0

e9/l

0.49

316

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

3.09

4.49

4.4

2.8

—

(3002256) Pathology report gross observation

2.87

4.26

1.3

1.2

—

(3032080) INR in Blood by Coagulation assay

309

2.30

4.11

4.9

7.0

1.0

1.2

inr

2.46

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

3.42

3.99

4.7

3.7

4.2

4.6

pmol/l

0.55

(3024561) Albumin [Mass/volume] in Serum or Plasma

350

2.24

3.88

5.2

4.6

34.6

36.2

g/l

0.86

334

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

148

2.45

3.81

3.5

2.9

164.1

75.4

ng/l

0.27

111

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

379

2.23

3.81

4.8

4.0

—

(3044640) Blood type and Crossmatch panel - Blood

271

2.18

3.57

2.1

2.3

—

(3026782) Osmolality of Urine

170

2.29

3.42

2.7

2.8

565.1

562.1

mosm/kgh2o

0.02

152

(3003458) Phosphate [Moles/volume] in Serum or Plasma

106

2.51

3.34

6.1

7.3

1.0

1.1

mmol/l

0.34

(40768804) Tissue Pathology biopsy report

320

2.10

3.34

2.1

2.0

—

(36304419) Bacteria [Presence] in Urine

244

2.14

3.30

3.0

2.9

—

(3030467) Casts [#/volume] in Urine by Automated count

246

2.11

3.22

2.9

3.0

0.5

0.4

e6/l

0.36

185

(3013826) Glucose [Moles/volume] in Serum or Plasma

475

2.02

2.87

6.5

4.4

6.5

6.7

mmol/l

0.31

437

(40768797) Stomach Pathology biopsy report

114

2.31

2.84

1.4

1.3

—

(3018095) Leukocytes [#/volume] in Urine

308

1.98

2.83

3.4

3.6

172.6

40.2

e6/l

0.52

221

(3052851) Hemolysis interference index of Serum or Plasma

4.01

2.74

4.6

3.0

—

(3002582) Erythrocytes [#/volume] in Urine

269

1.95

2.67

3.1

3.0

67.3

270.7

e6/l

0.40

207

(1616796) Gas panel - Central venous blood

5.24

2.44

5.2

3.4

—

(3023368) Bacteria identified in Blood by Culture

203

1.92

2.31

5.8

4.7

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

4.83

2.30

1.0

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

4.83

2.30

1.0

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

299

1.83

2.26

3.2

3.0

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

2.56

2.22

1.3

85.7

116.2

iu/ml

—

(3022948) Iron [Moles/volume] in Serum or Plasma

119

2.08

2.19

3.0

2.5

11.2

13.3

umol/l

0.82

108

(3002385) Erythrocyte distribution width [Ratio]

729

2.15

2.10

26.4

16.6

14.1

13.6

1.26

720

(3021901) Oxygen saturation in Capillary blood

5.19

2.09

4.0

2.3

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.53

2.04

5.3

5.2

24.6

25.1

mmol/l

0.19

(3027315) Oxygen [Partial pressure] in Blood

3.68

1.86

3.2

2.9

8.1

8.4

kpa

—

(3013290) Carbon dioxide [Partial pressure] in Blood

3.68

1.86

3.2

2.9

5.3

4.9

kpa

—

(3000991) Gas panel - Venous blood

2.20

1.86

5.6

7.8

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

3.47

1.77

1.2

1.6

—

(42870588) Differential panel, method unspecified - Blood

284

1.67

5.8

5.3

—

(40758558) Short blood count panel - Blood

214

1.72

1.66

7.6

6.6

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

285

1.66

1.64

3.2

29.2

31.7

u/l

0.32

266

(3013650) Neutrophils [#/volume] in Blood by Automated count

494

1.65

1.64

11.1

9.9

4.1

4.0

e9/l

0.21

436

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.81

1.61

1.3

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

3.12

1.60

1.3

1.5

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

2.97

1.53

1.8

183.7

167.0

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.43

1.47

7.2

7.6

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.83

1.45

1.0

1.5

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

3.04

1.37

1.0

1.4

—

(3026008) Bacteria identified in Urine by Culture

234

1.61

1.35

2.2

3.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

100

1.84

1.33

1.9

1.7

—

(3014051) Protein [Presence] in Urine by Test strip

2.87

1.30

2.4

1.8

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

867

2.07

1.27

23.2

15.0

139.2

139.7

mmol/l

0.78

843

(3023103) Potassium [Moles/volume] in Serum or Plasma

868

2.06

1.27

23.6

15.1

4.0

mmol/l

1.41

842

(3019060) Gas panel - Arterial blood

2.15

1.27

5.9

4.6

—

(40761536) Microorganisms panel - Urine sediment

1.92

1.21

3.8

4.1

—

(3049717) Cytology report of Urine Cyto stain

2.39

1.20

3.2

2.5

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

1.18

0.0

2.2

—

1.8

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

137

1.67

1.17

5.0

2.8

0.8

mmol/l

0.18

129

(3034770) Mitochondria Ab [Titer] in Serum

2.57

1.16

1.4

1.2

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

773

1.72

1.16

4.9

4.4

1.9

mu/l

0.09

690

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

189

1.58

1.15

1.6

2.3

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

2.45

1.10

1.8

1.6

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

157

0.53

1.10

1.3

1.5

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

800

1.73

1.08

21.9

12.8

82.5

83.5

ml/min/173m2

0.14

645

(3044889) 12 lead EKG panel

597

1.48

1.03

4.2

3.7

—

(3003694) ABO and Rh group [Type] in Blood

221

1.51

1.02

1.6

1.4

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.88

0.99

2.8

1.3

293.6

128.9

u/ml

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

894

1.91

0.96

24.7

15.8

83.2

77.2

umol/l

0.49

894

(3045414) Leukocytes [Presence] in Urine

2.13

0.91

2.2

1.6

—

(3021960) Folate [Moles/volume] in Serum or Plasma

182

1.49

0.89

1.6

1.5

18.9

22.1

nmol/l

0.45

150

(3020891) Body temperature

1.99

0.86

5.5

4.2

—

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

0.00

0.80

0.0

1.3

—

291.6

—

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

0.00

0.80

0.0

1.1

—

2.6

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.76

0.78

2.6

3.1

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

2.14

0.75

1.6

99.2

97.0

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

2.14

0.75

2.2

1.6

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.66

0.75

3.2

2.5

3.5

6.1

ug/l

—

(3019198) Lymphocytes [#/volume] in Blood

425

1.35

0.73

6.8

6.0

1.8

e9/l

0.06

383

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

310

1.36

0.73

4.7

4.0

27.6

38.2

ng/l

0.35

211

(3006315) Basophils [#/volume] in Blood

417

1.34

0.71

6.9

5.9

0.0

e9/l

0.35

369

(3001604) Monocytes [#/volume] in Blood

417

1.34

0.71

6.7

5.8

0.6

e9/l

0.22

370

(3029937) Albumin [Presence] in Urine by Test strip

218

1.39

0.70

3.5

4.1

0.0

estimate

0.00

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.50

0.70

17.0

6.9

—

(3000330) Specific gravity of Urine by Test strip

1.67

0.68

2.4

3.8

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

156

1.44

0.68

2.4

2.7

0.3

0.9

e6/l

2.19

(3037522) Nuclear Ab [Titer] in Serum

106

1.49

0.62

1.5

1.4

440.0

572.2

titre

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.61

0.0

3.0

—

52.1

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.60

0.0

1.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.57

0.55

2.0

1.6

—

(3020630) Protein [Mass/volume] in Serum or Plasma

1.42

0.52

1.7

3.2

66.0

66.8

g/l

—

(3000492) Spirometry study

0.58

0.48

1.0

1.4

—

(3022621) pH of Urine by Test strip

1.49

0.48

2.1

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.44

0.43

1.8

1.7

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.41

0.0

1.3

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.41

0.0

2.6

—

69.5

—

(3035350) Ketones [Presence] in Urine by Test strip

420

1.22

0.40

3.2

3.6

0.0

estimate

0.00

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

143

1.31

0.40

2.6

2.8

7.0

2.3

e6/l

0.55

(1002224) Polysomnography panel

1.41

0.39

1.0

1.1

—

(3012336) Haptoglobin [Mass/volume] in Serum or Plasma

1.41

0.39

2.4

2.1

1.5

1.6

g/l

—

(1761868) Lipid panel - Serum or Plasma

315

1.22

0.38

2.8

2.9

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.36

0.37

1.2

1.7

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.38

0.36

1.4

1.8

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.65

0.34

1.5

1.9

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

101

1.33

0.33

1.2

1.7

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.32

0.33

1.0

1.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

573

0.84

0.32

2.9

3.2

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

100

0.68

0.32

1.4

2.1

—

(40760892) CBC W Ordered Manual Differential panel - Blood

195

1.23

0.32

3.9

5.6

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

130

1.27

0.31

1.6

1.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

130

1.27

0.31

1.9

1.7

—

(3041096) Erythrocytes [Presence] in Urine by Automated

234

1.21

0.30

3.0

3.2

—

(3009261) Glucose [Presence] in Urine by Test strip

419

1.18

0.30

3.1

3.7

0.0

estimate

0.00

(3005719) IgG [Mass/volume] in Serum or Plasma

1.27

0.30

2.3

2.7

10.9

9.9

g/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

322

1.18

0.29

3.1

3.8

—

(40761511) CBC panel - Blood by Automated count

904

1.33

0.29

21.5

12.7

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

850

1.26

0.27

19.7

13.5

23.3

22.1

mg/l

0.14

664

(3042936) Bacteria identified in Isolate by Culture

114

1.26

0.27

1.7

1.9

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.71

0.25

1.3

1.8

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.37

0.24

1.6

1.3

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.73

0.23

1.1

1.4

—

(3021601) Nitrite [Presence] in Urine by Test strip

416

1.15

0.23

3.9

5.1

0.0

estimate

0.00

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

135

1.22

0.23

1.7

1.9

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.23

0.22

1.8

4.1

25.4

25.1

mmol/l

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.4

—

(44790049)

0.00

0.21

0.0

1.9

—

(44790047)

0.00

0.21

0.0

1.9

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.8

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.8

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.4

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.4

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.21

0.0

3.8

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.21

0.0

1.3

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.21

0.0

1.8

—

(44790048)

0.00

0.21

0.0

1.9

—

(44806118)

0.00

0.21

0.0

1.9

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.21

0.0

1.0

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.21

0.0

1.1

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.4

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.9

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.4

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.9

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.4

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.3

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.21

0.0

1.9

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.9

—

(40768795) Lymph node Pathology biopsy report

0.00

0.20

0.0

1.1

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

312

1.13

0.19

1.9

79.5

94.9

pmol/l

0.96

149

(3019225) pH of Specimen

1.18

0.18

4.0

5.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

576

0.90

0.16

3.9

4.2

—

(3022145) Colonoscopy Study observation

1.20

0.15

1.9

1.3

—

(3012516) Albumin [Mass/volume] in Urine

223

1.10

0.10

2.1

3.2

168.5

45.7

mg/l

0.43

145

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.12

0.10

2.0

1.4

—

(3015736) pH of Urine

332

1.08

0.10

3.8

3.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

165

1.11

0.09

1.9

2.0

—

(3007164) IgA [Mass/volume] in Serum or Plasma

175

1.11

0.09

1.7

1.4

5.5

2.5

g/l

0.63

103

(3024731) MCV [Entitic volume]

953

0.95

0.08

30.5

19.7

89.9

90.9

1.67

940

(3035941) MCH [Entitic mass]

953

0.95

0.08

30.5

19.7

29.9

30.3

1.48

939

(3000963) Hemoglobin [Mass/volume] in Blood

953

0.95

0.08

30.9

19.9

133.6

136.9

g/l

1.23

940

(3024354) Oxygen [Partial pressure] in Venous blood

0.85

0.08

1.5

3.0

4.8

5.0

kpa

—

(36660697) Celiac disease serology panel - Serum

0.81

0.08

1.2

1.1

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.04

0.07

1.8

1.7

—

(3012544) pH of Venous blood

1.08

0.07

2.0

4.4

—

(3013512) EKG study

244

0.93

0.07

3.1

3.6

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

1.06

0.07

1.6

4.4

5.3

5.8

kpa

—

(3000494) Fungus identified in Specimen by Culture

101

0.88

0.06

1.4

1.5

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

239

1.06

0.04

1.6

1.7

1.4

mmol/l

1.06

206

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

219

0.95

0.03

3.8

4.7

23.8

22.4

0.08

103

(3020682) Albumin/Creatinine [Ratio] in Urine

241

1.05

0.03

3.4

4.0

19.2

7.3

mg/mmol

0.35

149

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

193

1.05

0.01

1.2

1.3

1.0

0.9

u/ml

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

192

0.99

0.00

3.3

3.8

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

145

1.04

0.00

1.2

61.5

26.3

iu/ml

—

(3009542) Hematocrit [Volume Fraction] of Blood

789

1.01

0.00

18.8

14.0

39.9

40.6

0.38

597

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.6

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.1

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.4

—

(3027456) Digoxin [Moles/volume] in Serum or Plasma

0.00

0.0

3.5

—

0.8

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.6

—

(3026250) Tacrolimus [Mass/volume] in Blood

0.00

0.0

21.4

—

5.6

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.0

1.0

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.4

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

2.9

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.2

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.1

—

(3015076) Soybean IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3008898) HLA-B27 [Presence]

1.02

0.00

1.0

1.1

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.3

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.1

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.2

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3020491) Glucose [Moles/volume] in Blood

0.00

0.0

1.3

—

6.5

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.0

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

6.6

—

0.6

—

(4146454)

0.00

0.0

3.0

—

(3000012) Reticulocyte production index

0.00

0.0

1.0

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.4

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.5

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

2.4

—

(3045716) Anion gap in Serum or Plasma

0.00

0.0

1.2

—

7.8

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.7

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.0

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.3

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.7

—

(4010399)

0.97

0.00

1.2

1.5

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.01

0.00

3.1

1.7

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

1.9

—

13.8

—

(3017704) Immunofixation for Urine

0.00

0.0

1.8

—

(3051593) INR in Capillary blood by Coagulation assay

0.00

0.0

15.3

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

4.0

—

(4027681)

0.00

0.0

1.2

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

9.5

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.3

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

3.9

—

138.7

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

4.0

—

(4198724)

0.00

0.0

1.2

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.4

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.2

—

(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(40761535) Cells panel - Urine sediment

0.90

0.00

4.0

3.8

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.4

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.7

—

(3011648) Oxygen content in Venous blood

0.00

0.0

2.5

—

12.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_ADREMEDHYPER and mortality.

Females

Parameter	HR [95% CI]	p-value
E4_ADREMEDHYPER	2.134 [1.49, 3.05]	< 0.001
Birth year	0.993 [0.98, 1.0]	0.122

During the follow-up period (1.1.1998 — 31.12.2019), 66 out of 254 females with E4_ADREMEDHYPER died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_ADREMEDHYPER.

N-year risk	Females	Males
1	0.217%	No data
5	1.264%	No data
10	2.879%	No data
15	5.587%	No data
20	9.629%	No data

Relationships between endpoints

↥

Index endpoint: E4_ADREMEDHYPER – Adrenomedullary hyperfunction

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Adrenomedullary hyperfunction

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints