No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
87 |
4. Check minimum number of eventsNone |
87 |
5. Include endpointsNone |
87 |
6. Filter based on genotype QC (FinnGen only) |
80 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E06
- Name in latin
- Thyreoiditis ex medicamento
Similar endpoints
↥List of similar endpoints to
Drug-induced thyroiditis
based on the number of shared cases.
Similar with more cases:
- Thyroiditis
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 273 | 126 | 144 |
| Only index persons | 239 | 112 | 127 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 56.73 | 52.31 | 60.48 |
| Only index persons | 55.96 | 50.66 | 60.63 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 80 | 37 | 43 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 57.31 | 55.05 | 59.26 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 87
- Matched controls
- 870
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E06.4
ICD-10 Finland
Drug-induced thyroiditis
+∞
119.7
85
*
H03BB01
ATC
carbimazole; oral
1206.7
78.2
65
*
C01BD01
ATC
amiodarone; systemic
389.3
71.9
64
6
TFP20
NOMESCO Finland
Cardiodefibrillation
33.5
58.2
45
27
I48
ICD-10 Finland
Atrial fibrillation and flutter
25.7
53.4
64
85
207
Kela drug reimbursment
Chronic arrhythmias
23.1
51.6
56
63
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
550.0
36.9
34
*
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
13.2
32.6
43
60
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
12.6
32.3
46
71
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
15.2
32.0
35
37
B01AA03
ATC
warfarin; systemic
11.0
28.7
45
77
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
9.0
24.2
46
96
XF400
NOMESCO Finland
ECG with 12 standard connections
9.3
23.3
39
70
C03DA01
ATC
spironolactone; oral
10.2
22.5
32
47
H03AA01
ATC
levothyroxine sodium; systemic
36.7
22.2
28
11
TFP46
NOMESCO Finland
Ablation treatment of atrial fibrillation
51.2
19.7
23
6
TFP34
NOMESCO Finland
Electrophysiological investigation
40.6
19.6
24
8
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
19.5
18
*
XF404
NOMESCO Finland
Ambulatory ECG
9.9
18.9
26
36
I50.9
ICD-10 Finland
Heart failure, unspecified
9.0
18.9
29
46
C07AB07
ATC
bisoprolol; oral
11.3
18.9
75
310
WX404
NOMESCO Finland
Intravenous generell anesthesy
7.1
18.4
41
97
I48.1
ICD-10 Finland
Persistent atrial fibrillation
30.2
16.0
21
9
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
15.1
15.9
27
25
B01AF02
ATC
apixaban; oral
7.3
15.7
29
56
E05.89
ICD-10 Finland
Other thyrotoxicosis
+∞
15.0
14
*
C07AA07
ATC
sotalol; systemic
29.8
14.5
19
8
C01AA05
ATC
digoxin; systemic
16.9
13.9
22
17
TFC25
NOMESCO Finland
Transseptal catheterisation of left atrium or ventricle
34.6
13.6
17
6
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
12.3
13.1
24
26
TFP35
NOMESCO Finland
Electroanatomical mapping
29.7
13.1
17
7
201
Kela drug reimbursment
Chronic cardiac insufficiency
15.9
13.0
21
17
C03CA01
ATC
furosemide; systemic
5.1
12.7
42
135
I42.0
ICD-10 Finland
Dilated cardiomyopathy
23.0
12.2
17
9
C09AA05
ATC
ramipril; oral
4.9
12.1
42
140
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.3
11.9
63
290
104
Kela drug reimbursment
Thyroid insufficiency
+∞
11.7
11
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.3
11.4
30
79
K78
ICPC
Atrial fibrillation/flutter
9.4
10.5
22
30
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
5.1
10.2
27
71
R4110
NOMESCO Finland
Physiotherapy
4.3
10.1
41
150
C01BC04
ATC
flecainide; systemic
13.8
10.1
17
15
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
11.6
9.8
18
19
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
20.5
9.8
14
8
ZXE00
NOMESCO Finland
One hour or less
4.1
9.7
47
194
TPH04
NOMESCO Finland
Cathetrisation of vein
4.3
9.6
35
118
XF402
NOMESCO Finland
ECG with work load test
5.6
9.4
21
47
I50.1
ICD-10 Finland
Left ventricular failure
12.0
9.0
16
16
Z2221
NOMESCO Finland
Medical doctor
3.9
8.7
37
138
ZXD10
NOMESCO Finland
Scheduled procedure
3.7
8.5
46
201
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
11.8
8.4
15
15
I50.0
ICD-10 Finland
Congestive heart failure
8.5
8.0
17
24
Z3226
NOMESCO Finland
Physiotherapist
4.2
7.9
26
80
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
49.6
7.9
9
*
H02AB06
ATC
prednisolone; systemic
3.7
7.8
58
306
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
4.8
7.7
20
51
B01AF01
ATC
rivaroxaban; oral
4.4
7.4
22
62
K04
ICPC
Palpitations/awareness of heart
10.2
7.4
14
16
I47.2
ICD-10 Finland
Ventricular tachycardia
15.5
7.1
11
8
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
8.4
7.1
15
21
I46.0
ICD-10 Finland
Cardiac arrest with successful resuscitation
75.1
6.5
7
*
I47.1
ICD-10 Finland
Supraventricular tachycardia
12.4
6.5
11
10
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
29.0
6.3
8
*
AR6
HP
Catheter ablation of arrhythmia, target: atrial fibrillation
+∞
6.3
6
*
I49.0
ICD-10 Finland
Ventricular fibrillation and flutter
+∞
6.3
6
*
ZXE20
NOMESCO Finland
More than three and less than five hours
4.1
6.3
20
59
WX892
NOMESCO Finland
Monitored bed care
6.3
6.2
16
30
TPH07
NOMESCO Finland
Cathetrisation of artery
4.3
6.1
18
50
K80
ICPC
Cardiac arrhythmia NOS
6.1
6.1
16
31
XF600
NOMESCO Finland
Bloodpressure measurement
6.5
6.0
15
27
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
35
34
16.55
33.89
1.2
1.2
33.51
106.10
iu/ml
—
8
9
39
77
8.37
21.23
15.7
3.9
105.77
103.79
mmol/l
2.07
39
77
28
43
9.13
18.76
4.7
2.5
265.86
103.73
ng/l
2.08
28
37
36
84
6.61
16.16
3.8
2.4
2.45
2.45
g/l
0.01
36
74
37
95
6.04
14.87
4.1
2.4
13.28
12.69
umol/l
0.18
37
84
70
327
6.84
13.61
17.1
5.9
1.21
1.22
mmol/l
0.57
65
274
21
34
7.82
13.16
13.2
3.9
25.30
24.45
mmol/l
0.59
21
34
21
36
7.37
12.47
21.1
4.5
1.32
1.49
%
0.27
21
36
21
36
7.37
12.47
23.0
4.4
0.61
0.69
%
0.36
21
36
69
340
5.98
11.96
46.0
11.3
1.51
1.27
inr
0.41
12
111
21
25
10.70
10.84
6.5
2.8
23.91
23.82
mmol/l
0.06
21
25
73
416
5.69
9.55
15.2
10.2
4.17
4.23
e9/l
0.09
64
365
19
40
5.80
9.09
5.4
2.6
1.02
1.17
%
0.26
19
40
19
41
5.65
8.84
1.4
1.4
—
—
—
0
0
25
70
4.61
8.61
18.0
5.3
0.67
1.08
mmol/l
0.22
20
60
18
27
8.11
8.12
23.9
4.6
23.77
24.97
mmol/l
0.96
18
27
17
38
5.32
7.56
5.9
2.5
0.50
0.66
%
1.13
17
38
14
16
10.18
7.38
5.4
2.1
58.01
62.21
%
0.24
14
16
71
439
4.36
7.27
13.2
3.6
6.55
6.53
mmol/l
0.04
71
408
48
243
3.18
6.57
3.5
3.0
—
—
—
0
0
28
116
3.08
5.23
2.7
2.6
1.56
1.16
e6/l
0.21
17
68
34
160
2.85
5.04
4.0
2.2
—
—
—
0
0
10
14
7.91
4.80
1.3
1.4
—
—
—
0
0
38
198
2.63
4.55
2.9
2.9
0.80
0.27
e6/l
0.45
30
145
25
110
2.79
4.11
3.0
2.8
1.53
2.04
e6/l
0.15
15
62
8
11
7.87
3.95
1.0
1.4
—
—
—
0
0
8
11
7.87
3.95
1.1
1.8
—
—
—
0
0
42
242
2.42
3.95
2.4
1.7
96.57
91.81
pmol/l
0.22
28
118
47
285
2.41
3.94
8.0
3.3
23.16
52.37
ng/l
1.03
34
207
13
37
3.95
3.59
1.6
1.5
—
—
—
0
0
6
6
10.61
3.55
1.0
1.3
—
—
—
0
0
26
132
2.38
3.13
1.4
1.2
18.44
35.11
iu/ml
—
10
47
9
21
4.65
3.09
3.8
1.9
3.08
3.72
g/l
—
9
21
30
165
2.25
2.99
2.0
1.6
1.78
1.09
mg/l
0.58
24
130
7
13
5.75
2.93
1.3
1.2
0.00
0.00
g/l
—
7
13
7
13
5.75
2.93
1.3
1.2
0.00
0.00
g/l
—
7
13
21
100
2.45
2.88
2.4
2.0
—
—
—
0
0
17
74
2.61
2.79
2.4
1.9
—
—
—
0
0
7
15
4.97
2.65
1.3
1.4
0.00
0.00
g/l
—
7
15
48
331
2.00
2.57
4.0
2.6
—
—
—
0
0
16
72
2.50
2.45
2.2
1.9
—
—
—
0
0
8
23
3.72
2.33
1.3
1.3
—
—
—
0
0
7
18
4.13
2.30
1.3
1.3
0.00
0.81
g/l
—
7
18
5
9
5.81
2.24
1.6
1.0
75.00
99.89
%
—
5
9
6
14
4.52
2.19
1.0
1.1
—
—
—
0
0
7
20
3.71
2.10
5.4
1.8
200.14
170.70
%
—
7
20
6
15
4.21
2.07
1.7
1.3
—
—
—
0
0
6
15
4.21
2.07
1.5
1.1
—
—
—
0
0
6
16
3.94
1.97
1.2
1.5
—
—
—
0
0
7
23
3.22
1.84
1.4
1.4
1.27
1.16
g/l
—
7
23
7
23
3.22
1.84
1.4
1.4
0.25
0.24
g/l
—
7
23
74
633
2.13
1.74
49.1
15.6
14.37
15.17
%
0.89
74
621
6
19
3.31
1.69
1.2
1.2
—
—
—
0
0
5
14
3.72
1.64
1.2
1.1
—
—
—
0
0
7
26
2.84
1.62
2.7
2.1
—
—
—
0
0
6
20
3.14
1.61
1.8
4.0
41.48
50.02
mg/l
—
6
14
6
20
3.14
1.61
1.8
4.0
25.53
26.74
mg/l
—
6
14
9
37
2.59
1.53
2.0
1.8
—
—
—
0
0
6
22
2.85
1.46
1.3
1.1
—
—
—
0
0
14
78
1.95
1.30
12.1
7.2
—
—
—
0
0
6
25
2.50
1.26
1.0
1.1
—
—
—
0
0
6
25
2.50
1.26
1.0
1.1
—
—
—
0
0
30
213
1.62
1.25
5.5
3.8
22.63
9.51
mg/mmol
0.80
23
138
57
482
1.53
1.05
3.3
2.8
—
—
—
0
0
17
109
1.70
1.03
1.9
1.7
860.00
1300.42
nmol/l
1.90
17
85
6
27
2.31
0.95
1.3
3.2
—
—
—
0
0
5
24
2.15
0.76
1.0
1.8
—
—
—
0
0
0
21
0.00
0.61
0.0
2.6
—
46.75
—
0
11
0
21
0.00
0.61
0.0
1.4
—
—
—
0
0
0
23
0.00
0.59
0.0
1.2
—
—
—
0
0
6
39
1.58
0.54
1.0
1.2
—
—
—
0
0
25
304
0.75
0.53
3.4
3.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
0.66
—
0
8
10
75
1.38
0.32
1.4
1.4
—
—
—
0
0
18
149
1.26
0.31
1.5
1.7
508.00
467.66
pmol/l
0.22
18
131
23
198
1.22
0.28
2.5
2.6
0.74
0.72
ug/l
0.05
12
129
6
80
0.73
0.25
1.7
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
2.7
—
103.81
—
0
12
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
10
81
1.27
0.20
1.4
1.6
—
—
—
0
0
8
70
1.16
0.17
3.3
3.2
—
—
—
0
0
13
120
1.10
0.05
1.2
1.5
—
—
—
0
0
27
263
1.04
0.01
3.7
4.0
24.42
21.31
%
—
9
117
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
9.80
—
0
5
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
12.83
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYROIDITDRUG and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_THYROIDITDRUG.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_THYROIDITDRUG – Drug-induced thyroiditis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data