No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
80 |
4. Check minimum number of eventsNone |
80 |
5. Include endpointsNone |
80 |
6. Filter based on genotype QC (FinnGen only) |
80 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E06
- Name in latin
- Thyreoiditis ex medicamento
Similar endpoints
↥List of similar endpoints to
Drug-induced thyroiditis
based on the number of shared cases.
Similar with more cases:
- Thyroiditis
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 273 | 126 | 144 |
| Only index persons | 239 | 112 | 127 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 56.73 | 52.31 | 60.48 |
| Only index persons | 55.96 | 50.66 | 60.63 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 80 | 35 | 45 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 57.19 | 53.14 | 60.34 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 71
- Matched controls
- 709
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E06.4
ICD-10 Finland
Drug-induced thyroiditis
+∞
99.2
70
*
C01BD01
ATC
amiodarone; systemic
311.7
57.3
52
6
H03BB01
ATC
carbimazole; oral
+∞
57.2
47
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
+∞
31.6
28
*
I48
ICD-10 Finland
Atrial fibrillation and flutter
25.9
31.4
53
72
207
Kela drug reimbursment
Chronic arrhythmias
23.8
27.9
44
45
TFP20
NOMESCO Finland
Cardiodefibrillation
30.7
26.9
37
24
H03AA01
ATC
levothyroxine sodium; systemic
111.0
22.2
23
*
TFP46
NOMESCO Finland
Ablation treatment of atrial fibrillation
62.3
19.6
22
5
B01AA03
ATC
warfarin; systemic
11.7
17.5
37
60
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
11.1
16.6
36
60
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
25.4
16.5
23
13
TFP34
NOMESCO Finland
Electrophysiological investigation
38.9
16.3
20
7
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
16.3
15
*
C07AB07
ATC
bisoprolol; oral
9.9
15.7
59
235
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
11.2
15.4
32
48
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
11.8
14.7
29
39
TFP35
NOMESCO Finland
Electroanatomical mapping
67.6
14.5
16
*
K78
ICPC
Atrial fibrillation/flutter
24.7
14.4
20
11
E05.89
ICD-10 Finland
Other thyrotoxicosis
+∞
12.9
12
*
TFC25
NOMESCO Finland
Transseptal catheterisation of left atrium or ventricle
37.3
12.2
15
5
I42.0
ICD-10 Finland
Dilated cardiomyopathy
37.3
12.2
15
5
XF400
NOMESCO Finland
ECG with 12 standard connections
8.2
12.1
30
58
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
10.4
11.8
24
33
C07AA07
ATC
sotalol; systemic
34.2
11.2
14
5
C01AA05
ATC
digoxin; systemic
14.6
10.8
18
16
C03DA01
ATC
spironolactone; oral
10.1
10.8
22
30
104
Kela drug reimbursment
Thyroid insufficiency
+∞
10.7
10
*
C03CA01
ATC
furosemide; systemic
6.1
10.3
33
88
I50.9
ICD-10 Finland
Heart failure, unspecified
8.7
10.2
23
37
XF404
NOMESCO Finland
Ambulatory ECG
9.8
10.2
21
29
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.3
9.8
49
211
WX404
NOMESCO Finland
Intravenous generell anesthesy
5.7
9.8
34
99
C09AA05
ATC
ramipril; oral
5.4
9.4
34
103
C01BC04
ATC
flecainide; systemic
17.0
9.1
14
10
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
17.0
9.1
14
10
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
17.3
8.6
13
9
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
14.2
8.5
14
12
201
Kela drug reimbursment
Chronic cardiac insufficiency
13.1
8.2
14
13
B01AF02
ATC
apixaban; oral
8.9
8.1
17
24
I50.1
ICD-10 Finland
Left ventricular failure
15.7
7.7
12
9
B01AB04
ATC
dalteparin; parenteral
15.7
7.7
12
9
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
4.6
7.2
28
87
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.4
7.0
22
54
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
76.4
6.5
7
*
XF600
NOMESCO Finland
Bloodpressure measurement
9.1
6.5
13
17
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
14.3
6.3
10
8
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
5.9
6.1
17
36
K04
ICPC
Palpitations/awareness of heart
12.7
6.0
10
9
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
31
34
14.25
27.54
1.2
1.2
35.6
106.1
iu/ml
—
7
9
27
39
9.94
19.15
4.7
2.5
274.8
105.7
ng/l
2.10
27
33
53
186
6.48
15.31
6.6
2.7
1554.1
835.9
ng/l
1.25
53
152
20
30
8.56
13.44
13.6
4.0
25.4
24.7
mmol/l
0.40
20
30
31
78
5.86
12.64
4.1
2.5
2.4
2.4
g/l
0.07
31
68
32
89
5.33
11.53
4.4
2.4
12.7
12.9
umol/l
0.04
32
78
19
33
7.24
11.13
22.9
4.8
1.3
1.6
%
0.42
19
33
19
33
7.24
11.13
25.0
4.7
0.6
0.7
%
0.41
19
33
18
36
6.16
9.12
5.7
2.7
1.0
1.0
%
0.20
18
36
18
37
5.99
8.85
1.4
1.4
—
—
—
0
0
67
388
5.47
8.44
16.0
10.0
4.2
4.2
e9/l
0.04
60
340
23
65
4.56
7.84
19.3
5.2
0.7
1.2
mmol/l
0.25
18
54
16
34
5.63
7.54
6.3
2.6
0.5
0.7
%
1.73
16
34
10
13
8.65
7.29
1.3
1.4
—
—
—
0
0
65
399
4.36
6.80
14.0
3.6
6.6
6.6
mmol/l
0.17
65
370
33
145
3.17
5.72
4.1
2.2
—
—
—
0
0
43
225
2.97
5.42
3.7
3.1
—
—
—
0
0
13
33
4.51
4.93
1.6
1.4
—
—
—
0
0
41
226
2.67
4.46
2.4
1.8
96.2
91.1
pmol/l
0.23
27
111
8
10
8.73
4.16
1.1
1.9
—
—
—
0
0
8
10
8.73
4.16
1.0
1.4
—
—
—
0
0
6
5
12.81
3.82
1.0
1.4
—
—
—
0
0
34
183
2.49
3.75
3.1
3.0
0.9
0.2
e6/l
0.47
27
137
24
109
2.72
3.73
3.0
2.6
1.5
1.2
e6/l
0.11
15
66
20
88
2.70
3.27
2.3
2.1
—
—
—
0
0
22
103
2.57
3.18
3.3
2.9
1.6
2.1
e6/l
0.13
14
60
42
266
2.22
3.04
8.0
3.3
24.5
53.7
ng/l
0.94
31
195
8
18
4.81
2.88
4.1
2.1
2.9
3.5
g/l
—
8
18
16
67
2.74
2.85
2.3
1.9
—
—
—
0
0
23
120
2.29
2.60
1.4
1.2
19.4
37.8
iu/ml
—
9
43
15
65
2.61
2.49
2.1
1.9
—
—
—
0
0
6
12
5.31
2.45
1.0
1.1
—
—
—
0
0
26
147
2.14
2.41
2.2
1.6
2.0
1.1
mg/l
0.69
20
115
5
8
6.57
2.40
1.6
1.0
75.0
95.3
%
—
5
8
6
13
4.89
2.31
1.0
1.2
0.0
0.0
g/l
—
6
13
6
13
4.89
2.31
1.0
1.2
0.0
0.0
g/l
—
6
13
6
13
4.89
2.31
1.5
1.2
—
—
—
0
0
44
306
1.97
2.29
5.1
4.1
—
—
—
0
0
6
15
4.23
2.08
1.0
1.4
0.0
0.0
g/l
—
6
15
7
21
3.55
2.01
6.4
2.7
24.3
25.0
mmol/l
—
7
21
7
21
3.55
2.01
2.7
2.0
—
—
—
0
0
9
33
2.94
2.00
2.0
1.8
—
—
—
0
0
6
17
3.73
1.87
6.2
1.8
179.7
166.7
%
—
6
17
7
23
3.23
1.84
1.0
1.3
—
—
—
0
0
6
18
3.51
1.78
1.0
1.3
0.0
0.8
g/l
—
6
18
5
13
4.03
1.74
1.2
1.5
—
—
—
0
0
5
13
4.03
1.74
1.6
1.3
—
—
—
0
0
6
19
3.33
1.69
1.8
4.1
41.5
50.0
mg/l
—
6
14
6
19
3.33
1.69
1.8
4.1
25.5
26.7
mg/l
—
6
14
6
20
3.16
1.61
1.3
1.1
—
—
—
0
0
5
16
3.26
1.46
1.2
1.1
—
—
—
0
0
14
76
2.02
1.40
12.1
7.1
—
—
—
0
0
6
25
2.51
1.27
1.0
1.1
—
—
—
0
0
6
25
2.51
1.27
1.0
1.1
—
—
—
0
0
16
101
1.73
1.03
1.9
1.7
888.1
1305.0
nmol/l
1.65
16
78
8
43
1.95
0.90
7.8
2.6
4.9
5.1
kpa
—
8
38
5
25
2.06
0.74
1.4
3.4
—
—
—
0
0
22
283
0.69
0.70
3.5
3.6
—
—
—
0
0
50
440
1.36
0.62
3.3
2.8
—
—
—
0
0
0
20
0.00
0.61
0.0
2.7
—
50.7
—
0
10
0
20
0.00
0.61
0.0
1.2
—
—
—
0
0
6
37
1.67
0.57
1.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
0.9
—
0
5
23
192
1.28
0.38
2.5
2.7
0.7
0.7
ug/l
0.03
12
127
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
2.8
—
111.2
—
0
11
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
8
68
1.20
0.17
1.4
1.4
—
—
—
0
0
8
72
1.12
0.16
1.4
1.6
—
—
—
0
0
16
142
1.16
0.14
1.5
1.7
451.4
473.8
pmol/l
0.16
16
124
12
107
1.14
0.09
1.3
1.5
—
—
—
0
0
27
255
1.09
0.08
3.7
4.1
24.4
21.3
%
—
9
115
7
66
1.07
0.08
3.6
3.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
12.8
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
4.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYROIDITDRUG and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_THYROIDITDRUG.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_THYROIDITDRUG – Drug-induced thyroiditis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data