Drug-induced thyroiditis

E4_THYROIDITDRUG

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E06.4# Hospital discharge: ICD-9 — 2454 Cause of death: ICD-10 — E06.4# Cause of death: ICD-9 — 2454 2 out of 7 registries used, show all original rules.	80
4. Check minimum number of events None	80
5. Include endpoints None	80
6. Filter based on genotype QC (FinnGen only)	80

Control definitions (FinnGen only)

Control exclude: E4_THYROID

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E06
Name in latin: Thyreoiditis ex medicamento

NAME	E4_THYROIDITDRUG
CONTROL_EXCLUDE	E4_THYROID
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E064
HD_ICD_9	2454
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E064
COD_ICD_9	2454
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Drug-induced thyroiditis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	273	126	144
Only index persons	239	112	127
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	56.73	52.31	60.48
Only index persons	55.96	50.66	60.63

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	80	35	45
Unadjusted period prevalence (%)	0.02	0.01	0.02
Median age at first event (years)	57.19	53.14	60.34

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
71: Matched controls
709

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

E06.4

ICD-10 Finland

Drug-induced thyroiditis

+∞

99.2

C01BD01

ATC

amiodarone; systemic

311.7

57.3

H03BB01

ATC

carbimazole; oral

+∞

57.2

E05.9

ICD-10 Finland

Thyrotoxicosis, unspecified

+∞

31.6

I48

ICD-10 Finland

Atrial fibrillation and flutter

25.9

31.4

207

Kela drug reimbursment

Chronic arrhythmias

23.8

27.9

TFP20

NOMESCO Finland

Cardiodefibrillation

30.7

26.9

H03AA01

ATC

levothyroxine sodium; systemic

111.0

22.2

TFP46

NOMESCO Finland

Ablation treatment of atrial fibrillation

62.3

19.6

B01AA03

ATC

warfarin; systemic

11.7

17.5

FM1AE

NOMESCO Finland

Standard cardiac ultrasound examination

11.1

16.6

I48.0

ICD-10 Finland

Paroxysmal atrial fibrillation

25.4

16.5

TFP34

NOMESCO Finland

Electrophysiological investigation

38.9

16.3

E05.0

ICD-10 Finland

Thyrotoxicosis with diffuse goitre

+∞

16.3

C07AB07

ATC

bisoprolol; oral

9.9

15.7

235

290

Kela drug reimbursment

Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation

11.2

15.4

351

Kela drug reimbursment

Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation

11.8

14.7

TFP35

NOMESCO Finland

Electroanatomical mapping

67.6

14.5

K78

ICPC

Atrial fibrillation/flutter

24.7

14.4

E05.89

ICD-10 Finland

Other thyrotoxicosis

+∞

12.9

TFC25

NOMESCO Finland

Transseptal catheterisation of left atrium or ventricle

37.3

12.2

I42.0

ICD-10 Finland

Dilated cardiomyopathy

37.3

12.2

XF400

NOMESCO Finland

ECG with 12 standard connections

8.2

12.1

FM1BE

NOMESCO Finland

Cardiac ultrasound examination through oesophagus

10.4

11.8

C07AA07

ATC

sotalol; systemic

34.2

11.2

C01AA05

ATC

digoxin; systemic

14.6

10.8

C03DA01

ATC

spironolactone; oral

10.1

10.8

104

Kela drug reimbursment

Thyroid insufficiency

+∞

10.7

C03CA01

ATC

furosemide; systemic

6.1

10.3

I50.9

ICD-10 Finland

Heart failure, unspecified

8.7

10.2

XF404

NOMESCO Finland

Ambulatory ECG

9.8

10.2

GD1AA

NOMESCO Finland

Thorax X-ray examination

5.3

9.8

211

WX404

NOMESCO Finland

Intravenous generell anesthesy

5.7

9.8

C09AA05

ATC

ramipril; oral

5.4

9.4

103

C01BC04

ATC

flecainide; systemic

17.0

9.1

XFP20

NOMESCO Finland

Check up of cardiac pacemaker

17.0

9.1

Z95.0

ICD-10 Finland

Presence of electronic cardiac devices

17.3

8.6

I48.9

ICD-10 Finland

Atrial fibrillation and atrial flutter, unspecified

14.2

8.5

201

Kela drug reimbursment

Chronic cardiac insufficiency

13.1

8.2

B01AF02

ATC

apixaban; oral

8.9

8.1

I50.1

ICD-10 Finland

Left ventricular failure

15.7

7.7

B01AB04

ATC

dalteparin; parenteral

15.7

7.7

FN1AC

NOMESCO Finland

Angiography of heart and/or coronary arteries

4.6

7.2

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

5.4

7.0

ZXD10

NOMESCO Finland

Scheduled procedure

4.0

6.9

153

ZXE00

NOMESCO Finland

One hour or less

3.7

6.6

174

I42.9

ICD-10 Finland

Cardiomyopathy, unspecified

76.4

6.5

XF600

NOMESCO Finland

Bloodpressure measurement

9.1

6.5

Z45.0

ICD-10 Finland

Adjustment and management of cardiac devices

14.3

6.3

FM1DE

NOMESCO Finland

Doppler ultrasound examination of heart

5.9

6.1

K04

ICPC

Palpitations/awareness of heart

12.7

6.0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_THYROIDITDRUG and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_THYROIDITDRUG.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: E4_THYROIDITDRUG – Drug-induced thyroiditis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Drug-induced thyroiditis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints