Drug-induced thyroiditis

E4_THYROIDITDRUG

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E06.4# Hospital discharge: ICD-9 — 2454 Cause of death: ICD-10 — E06.4# Cause of death: ICD-9 — 2454 2 out of 7 registries used, show all original rules.	80
4. Check minimum number of events None	80
5. Include endpoints None	80
6. Filter based on genotype QC (FinnGen only)	80

Control definitions (FinnGen only)

Control exclude: E4_THYROID

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E06
Name in latin: Thyreoiditis ex medicamento

NAME	E4_THYROIDITDRUG
CONTROL_EXCLUDE	E4_THYROID
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E064
HD_ICD_9	2454
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E064
COD_ICD_9	2454
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Drug-induced thyroiditis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	273	126	144
Only index persons	239	112	127
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	56.73	52.31	60.48
Only index persons	55.96	50.66	60.63

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	80	35	45
Unadjusted period prevalence (%)	0.02	0.01	0.02
Median age at first event (years)	57.19	53.14	60.34

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
71: Matched controls
709

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

E06.4

ICD-10 Finland

Drug-induced thyroiditis

+∞

99.2

C01BD01

ATC

amiodarone; systemic

311.7

57.3

H03BB01

ATC

carbimazole; oral

+∞

57.2

E05.9

ICD-10 Finland

Thyrotoxicosis, unspecified

+∞

31.6

I48

ICD-10 Finland

Atrial fibrillation and flutter

25.9

31.4

207

Kela drug reimbursment

Chronic arrhythmias

23.8

27.9

TFP20

NOMESCO Finland

Cardiodefibrillation

30.7

26.9

H03AA01

ATC

levothyroxine sodium; systemic

111.0

22.2

TFP46

NOMESCO Finland

Ablation treatment of atrial fibrillation

62.3

19.6

B01AA03

ATC

warfarin; systemic

11.7

17.5

FM1AE

NOMESCO Finland

Standard cardiac ultrasound examination

11.1

16.6

I48.0

ICD-10 Finland

Paroxysmal atrial fibrillation

25.4

16.5

TFP34

NOMESCO Finland

Electrophysiological investigation

38.9

16.3

E05.0

ICD-10 Finland

Thyrotoxicosis with diffuse goitre

+∞

16.3

C07AB07

ATC

bisoprolol; oral

9.9

15.7

235

290

Kela drug reimbursment

Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation

11.2

15.4

351

Kela drug reimbursment

Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation

11.8

14.7

TFP35

NOMESCO Finland

Electroanatomical mapping

67.6

14.5

K78

ICPC

Atrial fibrillation/flutter

24.7

14.4

E05.89

ICD-10 Finland

Other thyrotoxicosis

+∞

12.9

TFC25

NOMESCO Finland

Transseptal catheterisation of left atrium or ventricle

37.3

12.2

I42.0

ICD-10 Finland

Dilated cardiomyopathy

37.3

12.2

XF400

NOMESCO Finland

ECG with 12 standard connections

8.2

12.1

FM1BE

NOMESCO Finland

Cardiac ultrasound examination through oesophagus

10.4

11.8

C07AA07

ATC

sotalol; systemic

34.2

11.2

C01AA05

ATC

digoxin; systemic

14.6

10.8

C03DA01

ATC

spironolactone; oral

10.1

10.8

104

Kela drug reimbursment

Thyroid insufficiency

+∞

10.7

C03CA01

ATC

furosemide; systemic

6.1

10.3

I50.9

ICD-10 Finland

Heart failure, unspecified

8.7

10.2

XF404

NOMESCO Finland

Ambulatory ECG

9.8

10.2

GD1AA

NOMESCO Finland

Thorax X-ray examination

5.3

9.8

211

WX404

NOMESCO Finland

Intravenous generell anesthesy

5.7

9.8

C09AA05

ATC

ramipril; oral

5.4

9.4

103

C01BC04

ATC

flecainide; systemic

17.0

9.1

XFP20

NOMESCO Finland

Check up of cardiac pacemaker

17.0

9.1

Z95.0

ICD-10 Finland

Presence of electronic cardiac devices

17.3

8.6

I48.9

ICD-10 Finland

Atrial fibrillation and atrial flutter, unspecified

14.2

8.5

201

Kela drug reimbursment

Chronic cardiac insufficiency

13.1

8.2

B01AF02

ATC

apixaban; oral

8.9

8.1

I50.1

ICD-10 Finland

Left ventricular failure

15.7

7.7

B01AB04

ATC

dalteparin; parenteral

15.7

7.7

FN1AC

NOMESCO Finland

Angiography of heart and/or coronary arteries

4.6

7.2

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

5.4

7.0

I42.9

ICD-10 Finland

Cardiomyopathy, unspecified

76.4

6.5

XF600

NOMESCO Finland

Bloodpressure measurement

9.1

6.5

Z45.0

ICD-10 Finland

Adjustment and management of cardiac devices

14.3

6.3

FM1DE

NOMESCO Finland

Doppler ultrasound examination of heart

5.9

6.1

K04

ICPC

Palpitations/awareness of heart

12.7

6.0

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

14.25

27.54

1.2

iu/ml

35.6

106.1

—

(3000991) Gas panel - Venous blood

10.80

21.50

20.8

4.9

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

9.94

19.15

4.7

2.5

ng/l

274.8

105.7

2.10

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

186

6.48

15.31

6.6

2.7

ng/l

1554.1

835.9

1.25

152

(3022217) INR in Platelet poor plasma by Coagulation assay

6.50

14.12

57.6

20.3

—

1.3

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

8.56

13.44

13.6

4.0

mmol/l

25.4

24.7

0.40

(3024928) Oxygen saturation in Venous blood

12.84

13.23

5.5

3.4

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

5.86

12.64

4.1

2.5

g/l

2.4

0.07

(3019230) Fractional oxyhemoglobin in Venous blood

11.91

12.60

5.4

2.3

58.0

63.8

0.33

(3022948) Iron [Moles/volume] in Serum or Plasma

5.33

11.53

4.4

2.4

umol/l

12.7

12.9

0.04

(3032080) INR in Blood by Coagulation assay

271

5.48

11.29

22.9

7.7

inr

1.6

1.2

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

7.24

11.13

22.9

4.8

1.3

1.6

0.42

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

7.24

11.13

25.0

4.7

0.6

0.7

0.41

(40758558) Short blood count panel - Blood

152

4.48

10.11

10.4

6.8

—

(3012544) pH of Venous blood

5.36

9.48

6.9

4.4

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

6.16

9.12

5.7

2.7

1.0

0.20

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

5.99

8.85

1.4

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

6.42

8.61

19.1

7.1

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

388

5.47

8.44

16.0

10.0

e9/l

4.2

0.04

340

(3003396) Base excess in Arterial blood by calculation

4.56

7.84

19.3

5.2

mmol/l

0.7

1.2

0.25

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

5.63

7.54

6.3

2.6

0.5

0.7

1.73

(3000492) Spirometry study

4.21

7.47

1.8

1.4

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

8.65

7.29

1.3

1.4

—

(3023368) Bacteria identified in Blood by Culture

169

3.55

7.19

8.1

4.0

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

8.02

6.86

1.3

1.4

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

399

4.36

6.80

14.0

3.6

mmol/l

6.6

0.17

370

(3006315) Basophils [#/volume] in Blood

329

3.55

6.38

9.6

5.7

e9/l

0.0

0.27

289

(3001604) Monocytes [#/volume] in Blood

329

3.55

6.38

9.6

5.6

e9/l

0.6

0.13

287

(3013115) Eosinophils [#/volume] in Blood

339

3.59

6.34

10.1

6.7

e9/l

0.2

1.04

305

(3019198) Lymphocytes [#/volume] in Blood

332

3.49

6.22

9.7

5.8

e9/l

1.8

0.15

295

(42870588) Differential panel, method unspecified - Blood

214

3.18

6.10

10.3

5.3

—

(3011648) Oxygen content in Venous blood

14.26

5.73

2.1

2.7

11.5

11.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

145

3.17

5.72

4.1

2.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

225

2.97

5.42

3.7

3.1

—

(3042733) HLA Ab [Presence] in Serum

+∞

5.26

2.8

0.0

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

4.51

4.93

1.6

1.4

—

(3044889) 12 lead EKG panel

479

3.80

4.76

10.5

3.7

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

3.46

4.72

1.7

1.5

—

(36304419) Bacteria [Presence] in Urine

169

2.76

4.55

3.1

2.8

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

226

2.67

4.46

2.4

1.8

pmol/l

96.2

91.1

0.23

111

(3006504) Eosinophils/100 leukocytes in Blood

310

2.63

4.20

11.0

5.7

2.3

2.9

1.53

292

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

8.73

4.16

1.1

1.9

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

8.73

4.16

1.0

1.4

—

(3019069) Monocytes/100 leukocytes in Blood

313

2.59

4.07

11.1

6.0

8.6

0.02

297

(3022096) Basophils/100 leukocytes in Blood

304

2.58

4.06

10.9

5.5

0.5

0.7

1.06

285

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

12.81

3.82

1.0

1.4

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

12.81

3.82

1.0

1.2

—

(3030467) Casts [#/volume] in Urine by Automated count

183

2.49

3.75

3.1

3.0

e6/l

0.9

0.2

0.47

137

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

109

2.72

3.73

3.0

2.6

e6/l

1.5

1.2

0.11

(3044640) Blood type and Crossmatch panel - Blood

200

2.45

3.70

4.5

2.3

—

(3042936) Bacteria identified in Isolate by Culture

2.78

3.68

2.5

2.0

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.84

3.58

2.1

1.4

—

(3023520) Reticulocytes [#/volume] in Blood

3.18

3.28

4.1

2.2

e9/l

69.8

73.7

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.70

3.27

2.3

2.1

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.73

3.22

1.8

1.5

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

103

2.57

3.18

3.3

2.9

e6/l

1.6

2.1

0.13

(3048929) Epstein Barr virus Ab [Presence] in Serum

5.43

3.14

1.0

1.4

—

(3009508) Creatinine [Moles/volume] in Urine

204

2.27

3.12

4.6

3.0

mmol/l

7.9

8.2

0.22

177

(3021589) Normoblasts [#/volume] in Blood

282

2.25

3.12

13.3

9.4

e9/l

0.0

0.50

227

(3002582) Erythrocytes [#/volume] in Urine

197

2.26

3.06

3.1

3.2

e6/l

216.8

84.8

0.51

152

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

266

2.22

3.04

8.0

3.3

ng/l

24.5

53.7

0.94

195

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

10.54

3.02

1.0

—

(3038026) Centromere Ab [Units/volume] in Serum

10.54

3.02

1.4

1.0

—

(4306422)

7.10

2.92

1.7

1.2

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

4.81

2.88

4.1

2.1

g/l

2.9

3.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

161

2.26

2.86

3.4

2.9

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.74

2.85

2.3

1.9

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

111

2.35

2.68

1.7

1.6

—

(3052851) Hemolysis interference index of Serum or Plasma

4.32

2.64

2.9

3.2

—

(3009542) Hematocrit [Volume Fraction] of Blood

619

3.05

2.60

52.9

13.7

41.6

40.4

0.90

459

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

120

2.29

2.60

1.4

1.2

iu/ml

19.4

37.8

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

7.52

2.58

2.0

1.7

—

(3035637) Corticotropin [Mass/volume] in Plasma

7.52

2.58

1.8

1.6

—

(3004616) Nuclear Ab [Presence] in Serum

7.52

2.58

2.2

1.0

—

(3018095) Leukocytes [#/volume] in Urine

226

2.08

2.56

5.0

3.8

e6/l

91.0

35.8

0.35

161

(3031040) Bacteria [#/volume] in Urine by Automated count

416

2.15

2.51

4.4

4.1

—

1192.9

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.61

2.49

2.1

1.9

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

5.31

2.45

1.0

1.1

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

147

2.14

2.41

2.2

1.6

mg/l

2.0

1.1

0.69

115

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

6.57

2.40

1.6

1.0

75.0

95.3

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

6.57

2.40

1.0

1.3

—

(3020891) Body temperature

3.74

2.34

4.1

3.0

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

4.89

2.31

1.0

1.2

g/l

0.0

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

4.89

2.31

1.0

1.2

g/l

0.0

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

4.89

2.31

1.5

1.2

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

306

1.97

2.29

5.1

4.1

—

(3012516) Albumin [Mass/volume] in Urine

185

1.99

2.18

5.1

3.3

mg/l

93.2

54.2

0.52

128

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

4.23

2.08

1.0

1.4

g/l

0.0

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

3.55

2.01

6.4

2.7

mmol/l

24.3

25.0

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.55

2.01

2.7

2.0

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.94

2.00

2.0

1.8

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

3.73

1.87

6.2

1.8

179.7

166.7

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.23

1.84

1.0

1.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.50

1.80

1.5

1.4

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

3.51

1.78

1.0

1.3

g/l

0.0

0.8

—

(3020682) Albumin/Creatinine [Ratio] in Urine

197

1.84

1.76

5.5

4.0

mg/mmol

22.6

9.8

0.77

129

(3041096) Erythrocytes [Presence] in Urine by Automated

200

0.43

1.74

5.5

3.6

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

4.03

1.74

1.2

1.5

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

4.03

1.74

1.6

1.3

—

(3034860) Kappa light chains.free [Mass/volume] in Serum

3.33

1.69

1.8

4.1

mg/l

41.5

50.0

—

(3047169) Lambda light chains.free [Mass/volume] in Serum or Plasma

3.33

1.69

1.8

4.1

mg/l

25.5

26.7

—

(3000494) Fungus identified in Specimen by Culture

2.14

1.68

1.5

1.3

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

3.16

1.61

1.3

1.1

—

(3002385) Erythrocyte distribution width [Ratio]

559

2.03

1.61

52.1

16.3

14.1

13.8

0.54

546

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

2.86

1.46

1.5

1.4

g/l

1.3

1.2

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

2.86

1.46

1.5

1.4

g/l

0.3

0.2

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

3.26

1.46

8.8

1.7

mg/l

10.4

13.3

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

3.26

1.46

1.2

1.1

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

2.02

1.40

12.1

7.1

—

(40761535) Cells panel - Urine sediment

2.24

1.34

3.8

2.9

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.43

1.31

1.3

1.4

—

(42529406) Shigella sp [Presence] in Stool by Culture

2.51

1.27

1.0

1.1

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.51

1.27

1.0

1.1

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

2.51

1.27

1.0

1.1

—

(3045414) Leukocytes [Presence] in Urine

2.41

1.21

1.3

1.4

—

(3022313) Gas panel - Capillary blood

2.41

1.21

6.3

2.5

—

(3049717) Cytology report of Urine Cyto stain

2.60

1.17

1.6

2.4

—

(40768443) Skin Pathology biopsy report

2.60

1.17

1.0

1.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

461

1.62

1.15

6.7

4.1

—

(40768804) Tissue Pathology biopsy report

247

1.57

1.12

1.9

2.0

—

(3025941) Bacteria identified in Stool by Culture

2.23

1.08

1.3

1.2

—

(3019309) Folate [Moles/volume] in Red Blood Cells

101

1.73

1.03

1.9

1.7

nmol/l

888.1

1305.0

1.65

(40768797) Stomach Pathology biopsy report

1.80

0.98

1.3

1.2

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.98

0.96

1.7

1.2

—

(3003694) ABO and Rh group [Type] in Blood

173

1.55

0.94

1.3

—

(4035726)

1.90

0.92

1.7

1.3

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

1.95

0.90

7.8

2.6

kpa

4.9

5.1

—

(4010399)

1.82

0.85

1.9

1.3

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.79

0.0

6.2

—

(3037121) Protein [Mass/volume] in Urine

2.25

0.77

8.6

4.0

g/l

0.7

0.1

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

2.06

0.74

1.4

1.0

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.06

0.74

1.4

3.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

283

0.69

0.70

3.5

3.6

—

(3019060) Gas panel - Arterial blood

1.73

0.70

2.9

4.3

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

440

1.36

0.62

3.3

2.8

—

(3050449) Albumin [Mass/time] in Urine collected for unspecified duration

0.00

0.61

0.0

2.7

—

50.7

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.61

0.0

1.2

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.67

0.57

1.0

1.2

—

(3002256) Pathology report gross observation

1.50

0.48

1.7

1.2

—

(3026008) Bacteria identified in Urine by Culture

179

1.32

0.43

3.1

2.9

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.41

0.0

1.4

—

(3023351) European house dust mite IgE Ab [Units/volume] in Serum

0.00

0.41

0.0

1.2

—

0.9

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.41

0.0

1.0

—

(1761868) Lipid panel - Serum or Plasma

251

0.78

0.38

2.7

2.9

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

192

1.28

0.38

2.5

2.7

ug/l

0.7

0.03

127

(3019150) Specific gravity of Urine by Refractometry

152

1.24

0.26

2.4

3.5

—

1.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

158

0.79

0.26

5.3

4.9

—

(21494755) Public health laboratory ask at order entry panel

1.32

0.25

1.1

1.5

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.21

0.0

1.1

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

2.8

—

111.2

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(36660697) Celiac disease serology panel - Serum

1.23

0.19

1.3

1.2

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.16

0.18

1.4

1.2

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.20

0.17

1.4

—

(3007164) IgA [Mass/volume] in Serum or Plasma

130

1.19

0.17

2.8

1.2

g/l

3.4

2.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.12

0.16

1.4

1.6

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

142

1.16

0.14

1.5

1.7

pmol/l

451.4

473.8

0.16

124

(3019225) pH of Specimen

1.14

0.09

16.3

3.6

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

107

1.14

0.09

1.3

1.5

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

255

1.09

0.08

3.7

4.1

24.4

21.3

—

115

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.07

0.08

3.6

3.2

—

(3022145) Colonoscopy Study observation

0.83

0.08

1.2

1.3

—

(3013512) EKG study

196

1.03

0.00

7.2

3.7

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.6

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.0

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.4

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(1175426) CD3 cells/100 lymphocytes in Blood

0.00

0.0

3.0

—

85.2

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

6.1

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

2.0

—

12.8

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.3

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.1

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.0

1.0

—

(4024509)

0.00

0.0

1.4

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(4027681)

0.00

0.0

1.3

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.1

—

248.3

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.0

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.1

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.0

2.7

—

4.4

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.0

1.0

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(4062490)

0.00

0.0

1.3

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.1

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3043453) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum

0.00

0.0

1.0

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

1.1

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.0

4.6

—

62.6

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

0.0

1.0

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

2.3

—

(3025547) Thyroglobulin Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

3.2

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

4.0

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

0.0

4.4

—

54.0

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.6

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

0.0

1.0

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(4146454)

0.00

0.0

1.6

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.1

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.7

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_THYROIDITDRUG and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_THYROIDITDRUG.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: E4_THYROIDITDRUG – Drug-induced thyroiditis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Drug-induced thyroiditis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints