No definition available.
Multiple system atrophy (rare forms of Parkinsonism)
G6_MULTIPLE_SYSTEM_ATROPHY
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
102 |
4. Check minimum number of eventsNone |
102 |
5. Include endpointsNone |
102 |
6. Filter based on genotype QC (FinnGen only) |
100 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Similar endpoints
↥List of similar endpoints to
Multiple system atrophy (rare forms of Parkinsonism)
based on the number of shared cases.
Similar with more cases:
- Autonomic disorders
- Other neurological diseases
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 100 | 42 | 58 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.03 |
| Median age at first event (years) | 70.44 | 69.48 | 71.13 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 102
- Matched controls
- 1020
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G90.3
ICD-10 Finland
Multi-system degeneration
+∞
147.1
102
*
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
121.8
124.0
70
18
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
123.0
105.1
56
10
G20
ICD-10 Finland
Parkinson disease
111.7
103.3
56
11
N87
ICPC
Parkinsonism
160.1
32.9
33
*
N04BC05
ATC
pramipexole; oral
12.5
31.8
39
48
N04BD01
ATC
selegiline; oral
92.3
20.6
22
*
N04BA03
ATC
levodopa, decarboxylase inhibitor and COMT inhibitor; oral
216.0
18.1
18
*
H02AA02
ATC
fludrocortisone; oral
52.1
18.1
21
5
N04BC04
ATC
ropinirole; oral
187.6
16.0
16
*
N04BD02
ATC
rasagiline; oral
160.5
13.8
14
*
193
Kela drug reimbursment
Rasagiline
134.6
11.7
12
*
XF606
NOMESCO Finland
Ortostatic test
+∞
11.7
11
*
R4130
NOMESCO Finland
Speech therapy
18.7
10.8
16
10
G23.2
ICD-10 Finland
Multiple system atrophy, parkinsonian type [MSA-P]
109.8
9.6
10
*
G23.3
ICD-10 Finland
Multiple system atrophy, cerebellar type [MSA-C]
+∞
9.5
9
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
5.5
8.8
19
41
I95.1
ICD-10 Finland
Orthostatic hypotension
8.1
8.6
19
28
G21.9
ICD-10 Finland
Secondary parkinsonism, unspecified
97.8
8.6
9
*
G23.9
ICD-10 Finland
Degenerative disease of basal ganglia, unspecified
97.8
8.6
9
*
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
16.3
8.5
13
9
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
36.6
8.2
10
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
5.0
7.6
18
42
N28
ICPC
Limited function/disability (N)
21.9
7.3
10
5
SPAT1229
SPAT
Assessment of need for aid
5.0
7.3
17
39
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
10.4
7.0
13
14
N03AE01
ATC
clonazepam; systemic
8.3
6.7
14
19
G23.8
ICD-10 Finland
Other specified degenerative diseases of basal ganglia
+∞
6.3
6
*
A06AD11
ATC
lactulose; oral
3.3
6.0
28
106
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
52
765
0.35
6.43
4.2
5.0
4.29
4.47
mmol/l
0.65
47
700
52
759
0.36
6.07
4.0
4.9
1.46
1.45
mmol/l
0.05
47
680
55
769
0.38
5.30
4.4
5.2
5.97
6.13
mmol/l
0.46
50
689
52
739
0.40
5.01
3.8
4.5
1.17
1.28
mmol/l
0.65
46
661
5
211
0.20
4.51
2.0
1.7
1.08
1.31
mmol/l
—
5
173
65
823
0.42
4.00
7.9
11.5
19.91
24.42
u/l
2.19
58
795
47
663
0.46
3.62
29.5
19.9
14.40
15.32
%
0.80
47
651
28
149
2.21
2.94
2.3
2.7
0.69
0.93
e6/l
0.35
19
96
12
44
2.96
2.65
2.3
5.1
26.12
24.12
mmol/l
0.76
12
44
69
823
0.50
2.54
20.5
19.8
70.45
82.35
umol/l
3.57
69
823
73
853
0.49
2.46
28.7
24.2
37.89
39.94
%
1.81
66
796
7
17
4.34
2.40
1.9
1.6
—
—
—
0
0
7
17
4.34
2.40
1.9
1.6
—
—
—
0
0
19
93
2.28
2.40
1.6
1.8
—
—
—
0
0
19
96
2.20
2.23
1.7
1.8
—
—
—
0
0
20
106
2.10
2.09
7.5
8.9
—
—
—
0
0
24
140
1.93
1.94
2.4
3.0
2.82
1.74
e6/l
0.20
15
88
15
272
0.47
1.93
1.5
2.4
51.40
73.04
u/l
—
10
249
60
724
0.58
1.83
4.7
4.9
1.86
2.04
mu/l
0.93
53
636
53
651
0.61
1.62
4.2
7.8
78.00
80.86
u/l
0.17
47
606
24
355
0.58
1.54
3.5
5.7
3.94
2.72
ug/l
0.33
19
314
36
254
1.64
1.52
3.5
3.1
0.93
0.37
e6/l
0.55
29
202
27
181
1.67
1.37
1.6
1.7
1067.95
1192.64
nmol/l
0.32
22
144
0
39
0.00
1.37
0.0
1.8
—
—
—
0
0
9
44
2.14
1.30
4.1
3.1
—
—
—
0
0
21
141
1.62
1.06
1.6
1.9
—
—
—
0
0
17
112
1.62
0.92
11.3
6.2
103.71
103.85
mmol/l
0.04
17
112
13
80
1.72
0.89
14.3
6.6
114.77
120.90
g/l
0.50
13
80
43
351
1.39
0.84
2.7
2.1
88.80
92.60
pmol/l
0.26
24
186
8
48
1.72
0.81
16.1
5.4
29.55
24.58
mmol/l
—
8
48
0
24
0.00
0.80
0.0
1.6
—
—
—
0
0
0
27
0.00
0.78
0.0
1.3
—
1.41
—
0
7
25
187
1.45
0.78
1.9
2.3
—
—
—
0
0
16
109
1.55
0.76
4.6
5.5
0.96
1.04
mmol/l
0.92
16
102
22
289
0.70
0.74
3.2
3.8
13.34
10.26
mg/mmol
0.10
13
181
40
328
1.36
0.74
3.6
3.2
—
—
—
0
0
72
780
0.74
0.64
19.8
16.2
31.03
24.21
mg/l
0.84
61
634
16
217
0.69
0.64
3.8
3.1
23041.36
8038.79
umol/l
0.28
11
174
0
22
0.00
0.60
0.0
1.2
—
—
—
0
0
52
582
0.78
0.55
3.8
4.1
14.67
15.04
pmol/l
0.40
43
513
42
479
0.79
0.51
5.4
10.0
5.73
4.32
e9/l
0.59
37
425
23
283
0.76
0.50
3.0
4.9
20.25
21.51
%
—
8
151
7
48
1.49
0.48
1.7
2.8
1.34
1.11
%
—
7
48
7
48
1.49
0.48
1.4
1.7
—
—
—
0
0
33
383
0.80
0.45
2.4
2.5
—
—
—
0
0
8
59
1.39
0.42
1.4
1.3
—
—
—
0
0
5
33
1.54
0.42
6.6
6.1
34.64
255.57
mg/l
—
5
25
5
33
1.54
0.42
6.6
6.1
22.82
31.85
mg/l
—
5
25
0
15
0.00
0.41
0.0
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
27
317
0.80
0.40
5.7
4.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
34
387
0.82
0.38
4.2
4.6
34.22
44.26
ng/l
0.31
23
294
34
385
0.82
0.36
2.1
2.2
—
—
—
0
0
43
391
1.17
0.29
10.3
5.7
1.20
1.21
mmol/l
0.60
37
355
6
84
0.70
0.25
1.0
1.3
—
—
—
0
0
6
84
0.70
0.25
1.3
3.3
5.33
9.92
umol/l
—
6
71
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
2.41
—
0
12
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
3.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
250.83
—
0
6
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
2.8
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
15.47
—
0
14
35
326
1.11
0.15
4.0
2.6
134.74
127.75
ug/l
0.12
30
293
18
201
0.87
0.15
2.2
3.1
0.56
0.85
ug/l
0.56
13
145
7
80
0.87
0.07
1.3
1.4
—
—
—
0
0
9
102
0.87
0.06
5.4
3.5
—
—
—
0
0
6
67
0.89
0.00
1.7
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
5.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.4
—
140.59
—
0
8
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
7.3
—
214.50
—
0
6
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
5.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
8.83
—
0
6
0
8
0.00
-0.00
0.0
1.3
—
152.75
—
0
8
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
90.50
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
5.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
9.20
—
0
5
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
13.68
—
0
5
0
6
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
16.00
—
0
6
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: G6_MULTIPLE_SYSTEM_ATROPHY – Multiple system atrophy (rare forms of Parkinsonism)
GWS hits: -
This endpoint is excluded (different definition than used in FinnGen).