Autonomic disorders

G6_AUTONOM

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G90
  • Cause of death: ICD-10 G90

2 out of 7 registries used, show all original rules.

779

4. Check minimum number of events

None

779

5. Include endpoints

801

6. Filter based on genotype QC (FinnGen only)

801

Control definitions (FinnGen only)

Control exclude
G6_OTHNEU

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G90-G99
Name in latin
Morbositates systematis nervosi autonomici

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6006 2906 3053
Only index persons 5139 2553 2586
Unadjusted period prevalence (%)
Whole population 0.08 0.08 0.09
Only index persons 0.10 0.09 0.10
Median age at first event (years)
Whole population 56.80 57.86 55.60
Only index persons 55.36 56.45 54.29

-FinnGen-

Key figures

All Female Male
Number of individuals 801 429 372
Unadjusted period prevalence (%) 0.15 0.15 0.16
Median age at first event (years) 56.53 55.19 58.08

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
712
Matched controls
7119
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G90.2
ICD-10 Finland
Horner syndrome
+∞
323.0
394
*
G90.0
ICD-10 Finland
Idiopathic peripheral autonomic neuropathy
+∞
115.9
108
*
G90.3
ICD-10 Finland
Multi-system degeneration
961.6
88.7
85
*
G90.9
ICD-10 Finland
Disorder of autonomic nervous system, unspecified
592.6
56.4
55
*
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
35.6
43.6
56
17
G90.8
ICD-10 Finland
Other disorders of autonomic nervous system
+∞
43.2
41
*
AA1AD
NOMESCO Finland
CT of head and brain
3.5
42.1
243
912
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
10.0
38.3
79
88
H02.4
ICD-10 Finland
Ptosis of eyelid
11.8
34.2
64
59
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
5.2
32.5
107
232
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
8.5
30.7
69
89
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
28.4
361
2102
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.6
27.7
102
248
H57.0
ICD-10 Finland
Anomalies of pupillary function
28.2
26.0
35
13
I67.0
ICD-10 Finland
Dissection of cerebral arteries, nonruptured
97.1
25.8
28
*
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
7.8
23.4
55
76
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
+∞
23.0
22
*
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
14.2
23.0
39
29
N03AX16
ATC
pregabalin; oral
2.5
22.2
211
1021
G20
ICD-10 Finland
Parkinson disease
7.1
22.1
55
83
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
118.7
21.7
23
*
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
+∞
20.9
20
*
H02AA02
ATC
fludrocortisone; oral
19.0
20.6
31
17
TAB00
NOMESCO Finland
Lumbar puncture
5.2
18.1
57
117
R51.80
ICD-10 Finland
Headache
2.8
18.0
125
497
R55
ICD-10 Finland
Syncope and collapse
3.1
18.0
106
379
G44.0
ICD-10 Finland
Cluster headache syndrome
17.1
18.0
28
17
G91.0
ICD-10 Finland
Communicating hydrocephalus
+∞
17.8
17
*
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
4.9
17.7
59
129
R53
ICD-10 Finland
Malaise and fatigue
2.4
17.5
173
841
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.5
17.1
85
268
XCK00
NOMESCO Finland
Perimetry
3.9
17.0
73
204
G90.1
ICD-10 Finland
Familial dysautonomia [Riley-Day]
+∞
16.7
16
*
PA6CG
NOMESCO Finland
Extensive MRI examination of neck vasculature with high intensity magnet
28.3
16.6
22
8
I95.1
ICD-10 Finland
Orthostatic hypotension
6.6
16.3
42
67
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
+∞
15.7
15
*
R42
ICD-10 Finland
Dizziness and giddiness
2.3
15.6
168
847
N04BC05
ATC
pramipexole; oral
3.3
14.9
77
251
N87
ICPC
Parkinsonism
10.7
14.8
28
27
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.8
14.2
61
171
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
7.3
14.0
33
47
N03AX12
ATC
gabapentin; oral
2.4
13.9
124
567
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
5.0
13.5
43
90
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
5.9
13.0
36
64
R4130
NOMESCO Finland
Speech therapy
7.2
13.0
31
45
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.1
13.0
73
252
G91.1
ICD-10 Finland
Obstructive hydrocephalus
+∞
12.5
12
*
G90.4
ICD-10 Finland
Autonomic dysreflexia
+∞
12.5
12
*
N02AX02
ATC
tramadol; systemic, rectal
1.8
12.5
302
2057
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.2
12.5
66
219
N06AX21
ATC
duloxetine; oral
2.6
12.2
96
409
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.3
12.2
125
609
CBJ40
NOMESCO Finland
Resection of levator muscle of eyelid
21.7
12.0
17
8
R4110
NOMESCO Finland
Physiotherapy
1.9
12.0
198
1175
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
11.9
208
1262
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.3
11.8
116
554
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.3
11.8
61
199
R13
ICD-10 Finland
Dysphagia
3.3
11.7
60
194
XF400
NOMESCO Finland
ECG with 12 standard connections
2.2
11.6
126
630
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
+∞
11.5
11
*
XA800
NOMESCO Finland
Neuropsychological investigation
4.2
11.4
43
108
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
11.3
276
1865
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
6.1
11.3
30
51
N28
ICPC
Limited function/disability (N)
7.8
11.2
25
33
N04BD01
ATC
selegiline; oral
7.6
11.0
25
34
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
3.4
11.0
54
170
J01MA02
ATC
ciprofloxacin; systemic
1.8
10.7
271
1850
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
7.5
10.5
24
33
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.4
10.4
95
436
R06.0
ICD-10 Finland
Dyspnoea
1.9
10.3
177
1057
PA7BD
NOMESCO Finland
CT angiography of neck and brain
9.8
10.3
20
21
I63.2
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
11.5
10.1
18
16
M03BX01
ATC
baclofen; systemic
7.4
10.0
23
32
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.5
9.7
75
316
A28
ICPC
Limited function/disability NOS
2.1
9.7
110
558
XF606
NOMESCO Finland
Ortostatic test
15.3
9.5
15
10
N06AX16
ATC
venlafaxine; oral
2.2
9.5
99
484
C08DA01
ATC
verapamil; systemic
3.7
9.5
40
112
EP1AE
NOMESCO Finland
Neck ultrasound examination
3.1
9.4
50
167
G99.2
ICD-10 Finland
Myelopathy in diseases classified elsewhere
+∞
9.4
9
*
3378X
ICD-9 Finland
Disorders of the autonomic nervous system[NEUROPATHIA AUTONOMICA PERIPHERICA ALIA DEFINITA]
+∞
9.4
9
*
PA6AD
NOMESCO Finland
CT of neck arteries
9.7
9.3
18
19
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
6.2
9.3
24
40
H02AB06
ATC
prednisolone; systemic
1.7
9.3
312
2284
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.0
9.2
119
638
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.6
9.2
65
260
R4120
NOMESCO Finland
Occupational therapy
2.9
9.2
57
210
N03AE01
ATC
clonazepam; systemic
2.9
9.2
54
194
N05AH04
ATC
quetiapine; oral
2.1
9.0
112
590
M03BX02
ATC
tizanidine; oral
1.6
8.9
407
3216
WX002
NOMESCO Finland
Sedation and analgesia
1.9
8.9
145
844
A02BC02
ATC
pantoprazole; systemic
1.6
8.9
433
3479
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
8.9
163
994
G93.3
ICD-10 Finland
Postviral fatigue syndrome
50.6
8.7
10
*
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
3.4
8.7
40
121
A02BC05
ATC
esomeprazole; systemic
1.6
8.6
281
2025
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
8.6
146
864
R01AD08
ATC
fluticasone; nasal
1.8
8.6
190
1225
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.9
8.6
127
717
N04BD02
ATC
rasagiline; oral
10.2
8.6
16
16
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
91.1
8.4
9
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.2
8.4
91
452
35800
ICD-8 Finland
Disease of peripheral autonomic nervous system, Syndroma Horner
+∞
8.3
8
*
G23.9
ICD-10 Finland
Degenerative disease of basal ganglia, unspecified
+∞
8.3
8
*
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
+∞
8.3
8
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.0
8.3
32
83
B01AA03
ATC
warfarin; systemic
1.8
8.1
139
827
PA6BG
NOMESCO Finland
MRI examination of neck vasculature with high intensity magnet
11.9
8.1
14
12
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.5
8.1
62
261
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.4
8.0
70
315
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
7.9
214
1464
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
9.5
7.8
15
16
H02AB07
ATC
prednisone; oral
2.0
7.8
107
587
A03FA01
ATC
metoclopramide; systemic, rectal
1.8
7.7
137
825
R52.2
ICD-10 Finland
Other chronic pain
3.8
7.6
31
85
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
7.6
177
1155
X59
ICD-10 Finland
Exposure to unspecified factor
1.9
7.5
124
725
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
7.5
229
1611
XCK10
NOMESCO Finland
Photography of fundus of eye
2.2
7.4
75
361
G23.3
ICD-10 Finland
Multiple system atrophy, cerebellar type [MSA-C]
+∞
7.3
7
*
G95.8
ICD-10 Finland
Other specified diseases of spinal cord
+∞
7.3
7
*
N99
ICPC
Neurological disease other
6.3
7.3
18
29
N06AX11
ATC
mirtazapine; oral
1.6
7.3
207
1429
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.1
7.2
79
395
M79.6
ICD-10 Finland
Pain in limb
1.6
7.2
230
1635
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
2.3
7.2
67
311
M01AE03
ATC
ketoprofen; systemic, rectal
1.6
7.2
251
1822
Q13.2
ICD-10 Finland
Other congenital malformations of iris
30.3
7.2
9
*
N04BC04
ATC
ropinirole; oral
6.7
7.1
17
26
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.0
7.1
94
505
N02BE01
ATC
paracetamol; systemic, rectal
1.7
7.1
578
5127
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
7.0
141
879
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.0
7.0
88
466
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.9
7.0
103
579
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.0
7.0
85
442
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.9
6.9
41
149
J01FA06
ATC
roxithromycin; oral
1.6
6.9
257
1891
B01AC07
ATC
dipyridamole; systemic
3.7
6.9
28
77
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
2.0
6.9
85
446
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
6.9
297
2261
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.1
6.9
78
395
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
5.1
6.8
20
40
ZXA00
NOMESCO Finland
Right side
1.6
6.8
181
1220
193
Kela drug reimbursment
Rasagiline
11.1
6.8
12
11
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.4
6.8
57
253
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.6
6.8
194
1335
CBJ30
NOMESCO Finland
Plastic repair of levator aponeurosis of eyelid
16.9
6.8
10
6
TDM10
NOMESCO Finland
Puncture of maxillary antrum
3.5
6.7
29
85
R03AC02
ATC
salbutamol; inhalant
1.5
6.7
338
2662
B01AC04
ATC
clopidogrel; oral
2.0
6.7
87
468
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.6
6.6
188
1291
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.2
6.6
65
311
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
6.5
177
1202
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
5.1
6.5
19
38
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
2.2
6.5
67
326
L28
ICPC
Limited function/disability (L)
1.8
6.5
104
604
G99.2*M50.0
ICD-10 Finland
Cervical disc disorder with myelopathy
70.5
6.4
7
*
XX2CT
NOMESCO Finland
Other injection with CT guidance
70.5
6.4
7
*
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
7.5
6.4
14
19
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.5
6.4
49
208
Z50.5
ICD-10 Finland
Speech therapy
5.6
6.3
17
31
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
4.6
6.3
20
44
G44.2
ICD-10 Finland
Tension-type headache
2.0
6.3
84
453
N06AB04
ATC
citalopram; systemic
1.7
6.3
139
890
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
9.4
6.3
12
13
N31.9
ICD-10 Finland
Neuromuscular dysfunction of bladder, unspecified
9.4
6.3
12
13
N17
ICPC
Vertigo/dizziness
2.0
6.3
74
382
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
4.9
6.3
19
40
G93.0
ICD-10 Finland
Cerebral cysts
+∞
6.3
6
*
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
+∞
6.3
6
*
R50.9
ICD-10 Finland
Fever, unspecified
1.9
6.2
93
525
N18
ICPC
Paralysis/weakness
5.1
6.2
18
36
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
7.8
6.1
13
17
H53.1
ICD-10 Finland
Subjective visual disturbances
2.5
6.1
44
181
ZXA05
NOMESCO Finland
Left side
1.6
6.1
167
1131
N29
ICPC
Neurological sympt/complt other
5.0
6.1
18
37
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.4
6.1
47
201
Z73.6
ICD-10 Finland
Limitation of activities due to disability
8.7
6.1
12
14
N04BA03
ATC
levodopa, decarboxylase inhibitor and COMT inhibitor; oral
6.8
6.1
14
21
N03AX11
ATC
topiramate; oral
3.6
6.0
25
71
A02BC03
ATC
lansoprazole; oral
1.6
6.0
184
1283
N02AA05
ATC
oxycodone; systemic
1.8
6.0
95
548
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
4.6
6.0
19
42
ZXA10
NOMESCO Finland
Bilateral
1.7
6.0
127
801

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
340
1801
2.54
35.22
2.6
2.1
216.1
275.5
u/l
0.43
317
1687
426
2838
2.07
22.30
7.2
5.9
1.2
1.2
mmol/l
1.05
390
2568
185
898
2.38
21.57
2.0
1.9
29.6
29.7
s
0.07
180
865
133
564
2.63
20.65
2.4
1.9
401.2
380.4
nmol/l
0.41
123
522
450
3114
2.02
20.58
8.3
6.5
1.2
1.2
mmol/l
0.13
381
2637
378
2508
1.96
19.01
8.4
9.0
1.2
1.2
inr
0.04
96
722
505
3706
1.98
18.75
5.9
4.6
6.6
6.7
mmol/l
0.36
481
3454
304
1880
1.99
18.68
4.5
3.8
7.4
7.4
ph
2.19
62
344
437
3096
1.91
17.55
7.2
5.9
27.0
27.9
%
0.93
413
2888
446
3183
1.91
17.49
7.0
5.6
0.6
0.6
e9/l
0.25
391
2749
455
3273
1.90
17.37
7.0
5.6
1.8
1.9
e9/l
0.97
411
2894
459
3317
1.90
17.21
7.3
5.9
0.2
0.2
e9/l
0.57
416
2918
328
2129
1.92
17.12
6.6
5.6
—
—
—
0
0
446
3198
1.89
17.08
7.0
5.6
0.0
0.0
e9/l
0.12
396
2768
426
3018
1.88
16.86
7.3
6.0
8.7
8.7
%
0.11
404
2830
424
3003
1.88
16.76
7.0
5.8
2.9
2.8
%
0.07
402
2791
414
2916
1.87
16.60
7.1
5.8
0.6
0.7
%
1.40
395
2722
429
3060
1.87
16.48
7.1
5.6
57.8
57.2
%
0.46
408
2877
386
2665
1.87
16.43
5.7
4.7
35.3
35.6
g/l
0.64
358
2471
29
50
5.98
16.28
1.1
1.1
0.5
1.9
nmol/l
—
6
8
275
1709
1.93
16.17
4.3
4.2
—
—
—
0
0
159
829
2.15
15.14
1.5
1.3
593.8
412.2
titre
0.38
32
174
167
889
2.11
15.06
2.7
2.3
2.4
2.3
g/l
0.15
161
823
253
1581
1.88
14.31
7.5
6.8
—
—
—
0
0
488
3716
1.80
14.26
10.0
9.1
4.4
4.1
e9/l
0.87
440
3253
144
742
2.15
14.06
1.9
1.6
—
—
—
0
0
155
826
2.09
13.85
2.9
2.4
23.3
23.0
%
0.08
139
705
172
961
2.01
13.47
2.9
2.3
13.0
13.2
umol/l
0.15
167
885
583
4727
1.86
13.38
5.3
4.0
12.0
12.3
mm/h
0.13
556
4335
38
103
3.82
12.51
1.4
1.2
—
—
—
0
0
364
2618
1.72
12.34
2.6
2.2
79.8
76.6
nmol/l
1.36
331
2332
263
1730
1.77
12.23
3.9
3.0
—
—
—
0
0
173
1003
1.92
12.05
4.0
3.2
0.8
0.8
mmol/l
0.00
165
941
193
1168
1.86
11.75
4.4
3.6
66.2
312.5
ng/l
3.56
149
901
266
1779
1.74
11.55
4.0
3.0
0.4
0.4
e6/l
0.19
200
1342
374
2750
1.68
11.39
3.5
2.7
124.1
137.2
ug/l
0.32
350
2527
38
111
3.54
11.24
1.4
1.1
41.9
7.7
e6/l
0.54
29
80
38
111
3.54
11.24
1.4
1.2
1474.1
1208.0
e6/l
0.07
30
83
39
118
3.42
10.94
1.3
1.1
3.7
3.7
mmol/l
0.01
34
108
321
2287
1.67
10.89
4.7
3.6
62.9
87.8
e6/l
0.45
228
1608
40
124
3.34
10.81
2.8
3.3
30.8
33.5
umol/l
0.30
34
105
280
1930
1.69
10.74
4.1
3.1
22.3
117.6
e6/l
2.02
216
1480
80
361
2.35
10.67
4.8
3.2
4.6
4.6
pmol/l
0.01
70
312
587
4908
1.73
10.54
9.2
7.5
79.4
78.5
u/l
0.15
554
4578
184
1132
1.81
10.50
1.8
1.7
1123.3
1184.5
nmol/l
0.43
149
841
96
472
2.17
10.44
3.5
2.5
9.7
10.7
g/l
1.78
86
434
206
1323
1.75
10.12
3.2
2.5
5.1
5.9
e6/l
0.36
175
1165
349
2575
1.63
10.12
2.4
1.9
95.8
95.1
pmol/l
0.11
188
1324
69
299
2.43
10.07
3.8
4.2
24.9
24.1
mmol/l
1.44
64
266
125
692
1.96
9.86
7.2
7.8
1.3
1.3
mmol/l
0.01
100
545
232
1560
1.69
9.57
2.6
2.0
2.9
3.1
mg/l
0.39
206
1315
323
2371
1.61
9.36
4.1
3.5
25.2
41.4
ng/l
2.69
216
1643
108
580
2.00
9.27
2.7
2.3
30.1
39.9
u/l
0.61
95
491
226
1520
1.68
9.27
2.4
2.2
—
—
—
0
0
423
3325
1.58
9.05
6.8
6.3
11.5
11.5
umol/l
0.00
397
3150
220
1485
1.66
8.84
1.7
1.5
20.0
20.7
nmol/l
0.33
198
1252
293
2125
1.60
8.80
3.3
3.4
2.3
2.4
mmol/l
1.31
252
1850
22
52
4.32
8.70
2.9
2.0
1.3
1.2
e9/l
0.15
15
26
162
1024
1.73
8.25
3.5
2.9
4.8
2.2
e6/l
1.20
96
560
21
51
4.20
8.03
1.4
1.4
—
—
—
0
0
24
65
3.78
7.95
1.3
1.3
—
—
—
0
0
67
320
2.19
7.83
8.3
9.4
24.8
24.5
mmol/l
0.30
62
298
276
2017
1.56
7.83
2.6
2.3
—
—
—
0
0
569
4876
1.58
7.68
4.9
3.8
14.9
14.8
pmol/l
0.28
531
4402
503
4196
1.53
7.66
6.4
4.3
1854.6
2999.8
e6/l
—
8
64
37
135
2.83
7.64
1.9
2.6
17.4
16.2
%
1.13
21
73
188
1262
1.64
7.58
3.6
2.7
552.0
557.6
mosm/kgh2o
0.12
153
1081
20
49
4.16
7.57
1.4
1.1
—
—
—
0
0
50
214
2.43
7.53
2.2
1.8
22.9
21.2
s
0.90
50
190
92
502
1.94
7.52
8.6
8.2
—
—
—
0
0
524
4428
1.53
7.36
5.6
4.2
—
—
—
0
0
75
384
2.05
7.34
2.0
1.7
1.3
1.6
g/l
0.94
65
354
658
5868
1.68
7.25
5.9
4.5
1.9
2.1
mu/l
0.32
615
5330
365
2869
1.50
7.23
11.2
9.2
0.0
0.0
e9/l
0.53
299
2335
206
1430
1.59
7.20
2.0
1.6
2.1
1.1
mg/l
0.49
152
1097
44
183
2.49
7.05
2.7
3.2
—
—
—
0
0
33
119
2.85
6.98
1.4
1.2
246.3
254.8
u/ml
0.05
24
69
48
209
2.38
6.97
1.7
2.3
142.1
446.5
ug/l
1.46
43
201
16
35
4.64
6.95
1.1
1.1
—
—
—
0
0
136
861
1.70
6.81
1.3
1.2
—
—
—
0
0
268
1996
1.51
6.77
2.8
2.5
52.7
56.2
u/l
0.91
245
1836
100
581
1.82
6.74
4.1
3.8
2.2
1.9
mmol/l
0.52
87
462
99
576
1.82
6.64
2.8
2.2
0.2
0.2
g/l
0.54
92
535
91
518
1.85
6.55
7.1
7.3
7.7
9.5
mmol/l
2.10
86
492
30
107
2.87
6.48
1.9
1.5
98.8
110.9
u/ml
—
6
19
80
439
1.91
6.44
1.3
1.2
132.1
151.6
iu/ml
0.12
29
176
702
6442
1.73
6.07
21.2
13.6
22.6
24.1
mg/l
0.55
594
5051
718
6632
1.80
6.05
22.6
15.5
139.6
139.7
mmol/l
0.46
703
6437
73
397
1.92
6.04
1.3
1.3
96.9
201.5
u/ml
2.47
65
364
22
68
3.30
6.04
1.5
1.3
—
—
nmol/l
—
0
0
719
6646
1.80
6.01
22.8
15.7
4.0
4.0
mmol/l
1.24
703
6443
61
313
2.03
5.95
8.2
10.9
—
—
—
0
0
78
436
1.87
5.94
4.2
4.0
7.4
7.4
ph
1.28
14
53
86
496
1.82
5.94
2.7
2.9
65.4
67.0
g/l
1.16
76
454
249
1871
1.48
5.88
4.1
3.0
—
—
—
0
0
31
119
2.67
5.87
1.9
1.5
—
—
—
0
0
180
1269
1.54
5.75
1.8
1.4
2.1
2.5
g/l
1.54
111
774
224
1655
1.49
5.73
3.0
2.5
3547.7
7314.2
umol/l
0.81
188
1442
126
820
1.64
5.65
7.2
5.4
1.0
1.0
mmol/l
0.01
121
756
151
1029
1.58
5.59
1.4
1.3
2.7
10.7
u/ml
3.59
49
410
164
1144
1.55
5.47
3.0
3.1
2.5
2.4
mmol/l
0.19
144
1000
32
130
2.52
5.43
2.2
3.2
2.7
2.5
mmol/l
0.13
22
90
157
1087
1.55
5.42
1.4
1.3
44.3
36.4
iu/ml
0.17
49
334
241
1825
1.46
5.39
2.8
2.9
872.5
1279.4
ng/l
1.55
207
1546
38
169
2.31
5.31
1.7
1.4
11.4
8.2
u/l
0.52
27
139
38
169
2.31
5.31
3.0
3.1
25.3
25.3
mmol/l
0.01
38
148
195
1426
1.49
5.18
1.4
1.3
7.5
1.8
u/ml
1.02
55
364
25
92
2.77
5.14
1.4
1.9
0.6
0.9
g/l
0.43
19
72
107
686
1.65
5.08
3.3
2.6
1.8
1.8
%
0.06
99
621
10
19
5.32
5.05
1.1
1.2
—
—
—
0
0
10
19
5.32
5.05
1.1
1.2
—
—
—
0
0
10
19
5.32
5.05
1.1
1.2
—
—
—
0
0
22
77
2.91
4.96
1.5
1.3
0.5
0.6
nmol/l
0.98
22
70
81
488
1.73
4.84
2.5
2.9
167.7
206.3
ng/l
0.27
72
446
195
1449
1.46
4.74
4.0
3.5
—
—
—
0
0
21
74
2.89
4.68
1.4
1.3
—
—
—
0
0
376
3140
1.37
4.63
4.5
3.5
0.0
0.0
estimate
0.00
69
594
19
64
3.02
4.58
1.3
1.1
—
—
—
0
0
67
391
1.78
4.48
5.0
5.5
—
—
—
0
0
378
3177
1.36
4.39
4.5
3.6
0.0
0.0
estimate
0.50
70
579
37
179
2.12
4.27
3.8
4.4
8.7
8.2
kpa
0.99
37
168
17
56
3.08
4.26
1.5
1.3
—
—
—
0
0
115
783
1.55
4.25
2.4
2.3
105.9
121.3
ug/g
0.26
89
618
109
739
1.55
4.10
3.9
2.7
10.5
7.9
umol/l
0.48
94
645
174
1300
1.43
4.06
1.8
1.7
429.3
22514495.4
pmol/l
1.32
145
1066
11
28
3.97
3.99
1.1
1.1
—
—
—
0
0
154
1131
1.45
3.93
2.1
1.8
—
—
—
0
0
355
2991
1.34
3.91
4.1
4.0
—
—
—
0
0
370
3140
1.33
3.87
6.1
4.9
0.0
0.0
estimate
0.50
71
603
11
29
3.83
3.81
1.8
2.5
460.6
710.6
u/ml
0.79
11
29
28
127
2.25
3.80
2.2
2.9
—
—
—
0
0
75
475
1.64
3.76
1.5
1.4
—
—
—
0
0
129
924
1.47
3.74
2.2
2.1
—
—
—
0
0
29
136
2.17
3.65
2.4
3.1
—
—
—
0
0
39
206
1.94
3.59
1.5
1.2
—
—
—
0
0
7
9
7.83
3.56
1.1
1.0
10.5
6.5
mg/g
—
7
9
22
93
2.40
3.51
1.3
1.2
4.8
6.7
u/ml
0.25
11
39
54
323
1.72
3.37
4.6
4.1
—
—
—
0
0
7
10
7.05
3.37
1.1
1.0
—
—
—
0
0
70
449
1.61
3.35
1.4
1.5
—
—
—
0
0
34
176
1.97
3.33
1.6
1.7
9.4
5.8
iu/l
0.44
12
50
27
129
2.13
3.27
3.4
2.9
—
—
—
0
0
64
406
1.63
3.21
2.6
2.6
—
—
—
0
0
8
15
5.38
3.19
2.6
1.7
—
—
—
0
0
23
104
2.25
3.18
1.2
1.3
82.3
65.6
mmol/l
0.70
18
90
76
505
1.56
3.15
2.4
2.4
5.8
6.8
ug/l
0.24
61
444
40
224
1.83
3.12
1.6
1.6
—
—
—
0
0
224
1815
1.33
3.09
3.2
3.3
653.6
184.7
mg/l
0.56
142
1171
33
174
1.94
3.09
1.0
1.1
—
—
—
0
0
8
16
5.04
3.05
1.1
1.1
—
—
—
0
0
13
45
2.92
3.03
1.2
1.2
—
—
—
0
0
36
198
1.86
2.98
1.2
1.2
—
—
—
0
0
15
57
2.66
2.98
9.3
5.0
82.0
52.3
u/ml
—
7
16
76
512
1.54
2.97
3.4
3.6
1.2
1.2
mmol/l
0.90
70
440
10
30
3.36
2.91
1.2
1.4
168.1
161.9
nmol/l
—
10
30
57
361
1.62
2.90
1.4
1.2
—
—
—
0
0
6
9
6.71
2.87
1.3
1.3
—
—
—
0
0
8
18
4.48
2.80
1.1
2.8
1.5
1.5
ug/l
—
8
18
100
722
1.44
2.80
1.8
1.6
—
—
—
0
0
5
6
8.38
2.75
1.6
1.5
—
—
—
0
0
44
266
1.69
2.69
1.6
1.3
19.7
26.1
iu/l
0.90
36
228
708
6745
1.43
2.68
18.2
12.7
—
—
—
0
0
296
2531
1.27
2.65
2.2
2.1
—
—
—
0
0
33
184
1.83
2.65
2.3
2.3
36.5
37.8
g/l
0.45
25
159
31
170
1.86
2.62
2.5
2.2
—
—
—
0
0
237
1978
1.28
2.57
3.1
3.2
7.8
7.7
mmol/l
0.06
193
1647
13
50
2.63
2.54
2.8
2.2
697.5
619.5
e6/l
—
6
19
72
499
1.49
2.50
1.2
1.2
—
—
—
0
0
18
82
2.22
2.49
1.0
1.2
—
—
—
0
0
176
1419
1.31
2.48
4.9
4.6
—
—
—
0
0
191
2308
0.77
2.47
2.9
2.8
—
—
—
0
0
32
182
1.79
2.43
1.4
1.4
333.7
300.8
ug/g
0.27
14
107
16
70
2.31
2.42
2.8
3.6
—
—
—
0
0
19
90
2.14
2.40
3.1
3.0
—
—
—
0
0
72
506
1.46
2.34
2.8
2.6
74.0
70.8
e9/l
0.27
53
388
99
739
1.39
2.32
1.3
1.3
—
—
—
0
0
23
121
1.93
2.22
1.4
1.2
—
—
—
0
0
491
4506
1.23
2.17
4.2
3.7
—
—
—
0
0
227
1920
1.25
2.16
4.1
4.0
13.5
7.8
mg/mmol
0.63
139
1229
16
74
2.19
2.16
1.5
1.4
64.2
47.4
mu/l
0.20
16
68
9
30
3.02
2.15
1.2
1.6
—
—
—
0
0
75
541
1.43
2.14
1.4
1.4
—
—
—
0
0
30
175
1.74
2.12
1.2
1.1
—
—
—
0
0
9
31
2.92
2.07
1.8
3.2
269.1
80.5
nmol/l
—
9
31
20
103
1.97
2.07
1.1
1.1
0.8
1.7
u/ml
—
9
42
67
479
1.44
2.02
4.5
3.6
74.2
81.5
ng/l
0.29
62
419
14
63
2.24
2.02
2.8
2.2
—
—
—
0
0
9
32
2.83
2.00
13.4
8.0
—
—
—
0
0
43
281
1.56
1.99
5.2
4.4
24.9
25.0
mmol/l
0.11
43
267
23
398
0.57
1.99
1.7
1.4
—
—
—
0
0
16
77
2.10
1.97
1.4
1.2
—
—
—
0
0
584
5484
1.24
1.97
26.2
17.5
332.0
332.6
g/l
0.92
578
5433
103
797
1.34
1.94
1.6
1.4
—
—
—
0
0
6
16
3.77
1.93
5.5
4.9
—
—
—
0
0
11
45
2.46
1.93
3.3
1.8
9.8
10.6
%
0.20
11
45
14
65
2.17
1.89
1.1
1.3
—
—
—
0
0
7
22
3.20
1.88
1.0
1.0
1299.3
1698.4
miu/ml
—
7
22
9
34
2.67
1.87
1.2
1.8
—
—
—
0
0
35
222
1.60
1.85
5.0
4.1
—
—
—
0
0
69
505
1.40
1.85
4.8
3.3
—
—
—
0
0
219
1876
1.23
1.83
4.2
3.7
—
—
—
0
0
20
108
1.87
1.83
1.1
1.0
5.3
9.0
u/ml
0.63
13
55
7
23
3.06
1.80
2.7
3.5
—
—
—
0
0
20
109
1.86
1.78
1.8
1.2
—
—
—
0
0
80
605
1.36
1.77
5.3
4.0
—
—
—
0
0
5
13
3.86
1.71
3.2
2.1
22.0
15.5
umol/l
—
5
13
11
48
2.31
1.71
1.7
3.7
—
—
—
0
0
116
931
1.29
1.70
1.8
1.6
—
—
—
0
0
20
112
1.81
1.65
1.4
1.8
—
—
—
0
0
7
25
2.82
1.65
2.7
3.3
—
—
—
0
0
19
105
1.83
1.64
1.2
1.2
—
—
—
0
0
5
14
3.59
1.61
1.4
1.1
1.3
2.4
mmol/l
—
5
14
14
70
2.02
1.60
2.3
2.5
—
—
—
0
0
6
20
3.01
1.58
1.2
1.1
—
—
—
0
0
18
99
1.84
1.58
1.1
1.5
—
—
—
0
0
573
5418
1.20
1.57
25.2
16.6
13.7
13.7
%
0.06
567
5305
80
618
1.33
1.56
1.6
1.5
—
—
—
0
0
21
123
1.73
1.52
1.1
1.1
0.7
1.3
u/ml
—
10
48
19
108
1.78
1.51
1.8
1.7
—
—
—
0
0
6
21
2.87
1.51
1.2
1.0
—
—
—
0
0
10
45
2.24
1.47
1.2
1.1
—
—
—
0
0
65
493
1.35
1.44
3.4
4.4
0.1
0.8
%
0.60
18
133
5
16
3.14
1.44
1.6
1.3
—
—
—
0
0
164
1399
1.22
1.42
5.2
3.8
1.0
1.0
kg/l
0.10
26
187
97
781
1.28
1.41
21.0
23.6
1.2
1.3
inr
—
8
111
21
127
1.67
1.37
1.4
1.8
—
—
—
0
0
71
553
1.31
1.33
3.2
4.2
1.0
1.0
%
0.06
24
176
71
553
1.31
1.33
5.2
3.7
—
—
—
0
0
6
24
2.51
1.30
1.2
1.0
—
—
—
0
0
62
476
1.33
1.29
2.6
2.2
17.0
12.8
nmol/l
0.76
55
426
5
18
2.79
1.28
1.4
1.8
—
—
—
0
0
17
99
1.73
1.28
1.1
1.1
—
—
—
0
0
15
84
1.80
1.27
9.5
6.1
11.5
11.2
mg/l
0.12
15
77
71
557
1.30
1.27
1.6
1.7
—
—
—
0
0
622
5966
1.19
1.27
23.0
14.5
39.1
39.9
%
1.37
448
4306
37
263
1.43
1.23
1.9
1.7
—
—
—
0
0
8
37
2.17
1.21
1.6
1.3
4.0
6.0
ug/l
—
8
31
29
198
1.48
1.18
1.4
1.6
—
—
—
0
0
0
33
0.00
1.16
0.0
1.1
—
—
—
0
0
5
20
2.51
1.15
2.2
16.1
—
—
—
0
0
192
1696
1.17
1.14
5.5
3.8
0.0
0.0
estimate
0.50
69
588
16
96
1.68
1.10
1.3
1.1
—
—
—
0
0
66
524
1.28
1.10
3.3
4.3
0.0
0.1
%
0.90
20
159
7
31
2.27
1.10
1.0
1.2
—
—
—
0
0
15
89
1.70
1.08
1.0
1.0
0.5
5.0
u/ml
—
7
30
6
122
0.49
1.06
1.2
1.5
—
—
—
0
0
53
412
1.31
1.05
1.1
1.2
—
—
—
0
0
28
196
1.44
1.03
1.7
2.2
3312.7
1724.5
u/l
—
5
68
17
106
1.62
1.03
1.6
1.3
—
—
—
0
0
195
1739
1.16
1.03
4.3
3.3
—
—
—
0
0
10
53
1.90
1.01
1.2
1.8
7.3
6.7
mmol/l
—
10
32
7
35
2.01
1.00
1.1
1.1
—
0.2
u/ml
—
0
6
0
29
0.00
0.98
0.0
1.4
—
—
—
0
0
12
69
1.75
0.97
1.2
1.2
—
—
—
0
0
9
50
1.81
0.97
1.2
1.1
—
—
—
0
0
20
133
1.52
0.95
8.6
9.8
104.6
105.5
mmol/l
0.30
20
120
20
133
1.52
0.95
8.5
9.8
12.8
11.4
mmol/l
0.37
20
120
9
51
1.77
0.94
1.6
1.1
—
—
—
0
0
6
118
0.50
0.94
1.2
1.4
—
—
—
0
0
6
118
0.50
0.94
1.2
1.4
—
—
—
0
0
12
70
1.73
0.93
2.0
1.2
—
—
—
0
0
19
126
1.52
0.92
1.8
1.3
—
—
—
0
0
51
403
1.28
0.91
3.1
2.8
—
—
—
0
0
79
659
1.22
0.90
3.1
4.4
2.9
25.3
ug/l
1.18
61
545
32
237
1.36
0.89
1.8
1.7
—
—
—
0
0
34
255
1.35
0.88
1.3
1.3
—
—
—
0
0
610
5900
1.14
0.87
6.2
5.7
40.0
39.7
mmol/mol
0.31
572
5453
11
64
1.73
0.86
1.3
1.3
—
—
—
0
0
61
498
1.24
0.85
3.3
4.1
0.3
0.6
%
0.57
15
126
16
104
1.55
0.85
2.3
3.0
—
—
—
0
0
13
80
1.64
0.85
1.2
1.6
—
—
—
0
0
13
80
1.64
0.85
1.2
1.6
—
—
—
0
0
13
80
1.64
0.85
1.2
1.6
—
—
—
0
0
13
80
1.64
0.85
1.2
1.6
—
—
—
0
0
18
121
1.50
0.83
2.9
3.9
58.3
57.2
%
0.15
18
121
8
46
1.75
0.82
1.0
1.2
—
—
—
0
0
12
73
1.65
0.82
1.7
1.5
19.5
16.9
ug/l
0.19
12
73
6
32
1.88
0.82
1.0
1.0
—
—
—
0
0
94
806
1.19
0.82
1.4
1.3
—
—
—
0
0
14
89
1.58
0.81
2.6
2.8
3.5
47.7
u/ml
0.50
14
84
705
6899
1.18
0.81
13.5
10.1
26.5
26.5
u/l
0.00
681
6635
33
250
1.33
0.81
1.8
1.7
—
—
—
0
0
33
251
1.33
0.79
1.8
1.7
—
—
—
0
0
11
66
1.68
0.79
1.3
1.2
38827.8
42663.2
e6/l
—
6
41
0
26
0.00
0.78
0.0
1.0
—
—
—
0
0
6
34
1.77
0.76
1.0
1.0
—
—
—
0
0
33
253
1.32
0.76
1.8
1.7
—
—
—
0
0
9
53
1.71
0.75
1.9
1.4
—
—
—
0
0
231
2130
1.12
0.73
4.3
4.8
2.3
3.0
ug/l
0.82
202
1894
9
55
1.64
0.73
1.2
1.3
—
—
—
0
0
40
317
1.28
0.73
1.4
1.7
—
—
—
0
0
14
92
1.53
0.72
2.6
2.9
—
—
—
0
0
9
56
1.61
0.72
1.8
1.5
—
—
—
0
0
17
117
1.46
0.72
2.7
3.5
4.0
4.3
e9/l
0.35
17
117
10
158
0.63
0.71
1.6
1.3
—
—
—
0
0
9
58
1.56
0.70
5.2
2.0
—
—
—
0
0
19
135
1.42
0.69
2.2
2.0
—
—
—
0
0
20
144
1.40
0.68
5.0
4.2
—
—
—
0
0
23
170
1.36
0.68
1.1
1.2
—
653.3
—
0
6
22
163
1.36
0.65
1.5
2.3
84.4
91.8
ug/min
0.05
15
89
619
6339
0.90
0.63
4.9
4.3
1.4
1.5
mmol/l
0.36
563
5819
11
71
1.56
0.62
1.3
1.2
2644.7
1321.5
e6/l
—
6
50
32
253
1.28
0.62
1.8
1.7
—
—
—
0
0
0
21
0.00
0.60
0.0
1.3
—
15.8
—
0
14
26
332
0.78
0.59
4.5
3.0
19.2
61.5
u/ml
1.89
26
320
12
82
1.47
0.54
1.0
1.0
1.5
7.3
u/ml
—
6
28
15
108
1.40
0.53
1.1
1.1
—
—
—
0
0
638
6246
1.11
0.53
4.8
4.4
5.9
5.9
mmol/l
0.05
586
5674
636
6485
0.91
0.51
5.4
4.8
2.7
2.8
mmol/l
1.26
584
5949
6
41
1.47
0.50
1.5
2.4
537.5
501.6
min
—
6
25
7
46
1.53
0.48
1.1
1.0
331.0
275.7
mg/l
—
7
39
11
76
1.45
0.48
1.5
4.7
—
—
—
0
0
626
6376
0.92
0.45
4.9
4.3
4.6
4.7
mmol/l
1.70
573
5881
15
112
1.35
0.45
1.1
1.1
—
—
—
0
0
731
7224
1.14
0.44
30.2
20.0
249.7
249.2
e9/l
0.08
717
7020
31
258
1.21
0.42
6.5
6.6
1.6
1.6
%
0.33
31
244
78
701
1.12
0.42
1.6
1.7
—
—
—
0
0
731
7228
1.13
0.42
30.0
19.9
30.3
30.3
pg
0.14
721
7107
731
7228
1.13
0.42
30.1
19.9
91.1
90.9
fl
0.52
721
7107
731
7229
1.13
0.41
30.1
20.0
4.4
4.5
e12/l
2.24
713
7007
731
7231
1.13
0.40
30.3
20.1
133.7
135.7
g/l
2.94
721
7108
10
137
0.73
0.39
1.3
1.8
—
—
—
0
0
9
69
1.31
0.37
2.4
2.7
—
—
—
0
0
9
69
1.31
0.37
1.1
1.0
—
—
—
0
0
30
253
1.19
0.37
6.7
6.7
1.0
0.9
%
0.76
30
237
9
71
1.27
0.36
1.6
1.6
—
—
—
0
0
14
179
0.78
0.36
5.3
4.5
—
—
—
0
0
56
625
0.89
0.34
1.4
1.4
—
—
—
0
0
730
7230
1.11
0.34
30.2
20.0
7.0
6.7
e9/l
1.15
715
7006
14
110
1.28
0.32
1.1
1.7
—
—
—
0
0
54
599
0.89
0.31
1.5
1.4
—
—
—
0
0
29
250
1.17
0.30
1.7
3.7
0.3
0.3
g/l
—
10
103
170
1787
0.94
0.29
1.4
1.4
—
—
—
0
0
36
317
1.14
0.28
3.7
3.5
—
—
—
0
0
14
112
1.25
0.28
1.1
1.1
—
—
—
0
0
12
95
1.27
0.26
1.0
1.6
—
—
—
0
0
9
76
1.19
0.24
1.3
1.7
—
—
—
0
0
604
6114
0.95
0.23
4.4
3.9
1.3
1.3
mmol/l
0.04
551
5575
5
38
1.32
0.23
1.4
3.9
—
—
—
0
0
5
39
1.28
0.23
4.0
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.8
—
—
—
0
0
0
12
0.00
0.21
0.0
2.9
—
—
—
0
0
0
12
0.00
0.21
0.0
5.8
—
—
—
0
0
18
154
1.17
0.21
1.4
1.8
30009.8
13417.5
e6/l
0.34
12
113
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
6
52
1.15
0.19
1.7
2.3
595.7
642.2
ml
—
6
29
7
59
1.19
0.18
1.0
1.3
6.4
6.5
mmol/l
—
7
54
23
254
0.90
0.14
1.0
1.1
—
—
—
0
0
11
128
0.86
0.13
1.3
1.1
—
—
—
0
0
30
277
1.09
0.13
1.0
1.1
—
—
—
0
0
10
116
0.86
0.12
1.1
1.2
81.7
24.4
u/l
—
10
99
33
308
1.07
0.11
3.0
2.4
—
—
—
0
0
176
1722
1.03
0.10
1.8
1.7
1.4
1.4
mmol/l
0.06
148
1444
7
68
1.03
0.08
1.9
1.2
—
—
—
0
0
10
90
1.11
0.05
1.0
1.1
1.6
1.5
g/l
—
10
81
44
445
0.99
0.00
2.5
3.0
4.3
4.2
e9/l
0.05
32
355
19
191
0.99
0.00
12.3
9.4
—
—
—
0
0
20
199
1.01
0.00
1.1
1.3
162.5
251.1
miu/ml
—
6
106
125
1252
1.00
0.00
2.8
2.9
0.7
0.7
ug/l
0.26
76
810
26
259
1.00
0.00
3.4
2.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
9
92
0.98
0.00
2.4
2.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
5.2
—
—
—
0
0
9
94
0.96
0.00
2.4
2.5
4.1
4.1
mmol/l
—
9
94
9
94
0.96
0.00
2.4
2.5
106.8
105.4
mmol/l
—
9
94
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
174.6
—
0
5
5
49
1.02
0.00
2.6
1.4
—
—
—
0
0
8
82
0.98
0.00
2.1
2.1
33.3
32.8
pg
—
8
82
0
6
0.00
0.00
0.0
1.3
—
31.3
—
0
6
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
15.6
—
0
5
0
5
0.00
0.00
0.0
5.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
3.8
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint G6_AUTONOM and mortality.

Females

Parameter HR [95% CI] p-value
G6_AUTONOM 2.775 [2.37, 3.25] < 0.001
Birth year 0.994 [0.99, 1.0] 0.162

During the follow-up period (1.1.1998 — 31.12.2019), 671 out of 2348 females with G6_AUTONOM died.

Males

Parameter HR [95% CI] p-value
G6_AUTONOM 2.517 [2.17, 2.92] < 0.001
Birth year 0.988 [0.98, 1.0] 0.013

During the follow-up period (1.1.1998 — 31.12.2019), 798 out of 2520 males with G6_AUTONOM died.

Mortality risk

Mortality risk for people of age

years, who have G6_AUTONOM.

N-year risk Females Males
1 0.269% 0.529%
5 1.548% 2.991%
10 3.906% 7.184%
15 7.323% 13.304%
20 12.638% 22.103%

Relationships between endpoints

Index endpoint: G6_AUTONOM – Autonomic disorders

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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