Idiopathic peripheral autonomic neuropathy

G6_IDIOAUT

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G90.0 Hospital discharge: ICD-9 — 3370 Cause of death: ICD-10 — G90.0 Cause of death: ICD-9 — 3370 2 out of 7 registries used, show all original rules.	132
4. Check minimum number of events None	132
5. Include endpoints None	132
6. Filter based on genotype QC (FinnGen only)	128

Control definitions (FinnGen only)

Control exclude: G6_AUTONOM

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: G90
Name in latin: Neuropathia autonomica peripherica idiopathica

NAME	G6_IDIOAUT
CONTROL_EXCLUDE	G6_AUTONOM
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G900
HD_ICD_9	3370
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G900
COD_ICD_9	3370
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Idiopathic peripheral autonomic neuropathy based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	941	432	497
Only index persons	774	372	402
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.02
Median age at first event (years)
Whole population	57.97	60.25	55.86
Only index persons	55.19	57.82	52.76

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	128	64	64
Unadjusted period prevalence (%)	0.03	0.02	0.03
Median age at first event (years)	61.87	57.71	66.03

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
132: Matched controls
1320

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G90.0

ICD-10 Finland

Idiopathic peripheral autonomic neuropathy

+∞

184.7

130

R55

ICD-10 Finland

Syncope and collapse

13.2

46.1

AA1AD

NOMESCO Finland

CT of head and brain

3.5

10.7

219

XFP20

NOMESCO Finland

Check up of cardiac pacemaker

5.6

10.2

I49.5

ICD-10 Finland

Sick sinus syndrome

9.1

9.2

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

4.9

8.8

FPE20

NOMESCO Finland

Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes

8.9

8.7

N03AX16

ATC

[U] pregabalin

3.1

7.9

178

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

4.4

7.3

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

4.5

7.2

Z45.0

ICD-10 Finland

Adjustment and management of cardiac devices

8.3

7.1

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

3.9

7.1

XF404

NOMESCO Finland

Ambulatory ECG

4.0

6.9

A02BC05

ATC

esomeprazole; systemic

2.6

6.8

342

Z03.3

ICD-10 Finland

Observation for suspected nervous system disorder

5.6

6.5

F32.9

ICD-10 Finland

Depressive episode, unspecified

3.6

6.4

G62.8

ICD-10 Finland

Other specified polyneuropathies

+∞

6.3

G91.0

ICD-10 Finland

Communicating hydrocephalus

+∞

6.3

G90.9

ICD-10 Finland

Disorder of autonomic nervous system, unspecified

+∞

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

515

2.74

7.14

6.7

6.5

1.21

mmol/l

0.27

429

(3018418) pH of Serum or Plasma

314

2.59

6.56

3.3

3.9

7.40

0.08

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

470

2.53

6.34

6.3

5.2

1.21

mmol/l

0.39

409

(3022217) INR in Platelet poor plasma by Coagulation assay

476

2.41

5.72

13.1

14.8

1.18

1.27

inr

0.40

147

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

374

2.17

4.53

3.7

3.4

—

(3023368) Bacteria identified in Blood by Culture

269

2.23

4.44

3.5

4.4

—

(3019309) Folate [Moles/volume] in Red Blood Cells

195

2.33

4.31

1.7

1.8

1139.45

1196.98

nmol/l

0.13

146

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

401

2.09

4.16

4.1

20.05

37.36

ng/l

1.98

291

(3007853) Bacteria identified in Skin by Aerobe culture

118

2.50

3.82

1.7

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

146

2.37

3.80

2.8

2.7

2.37

2.35

g/l

0.10

133

(3037522) Nuclear Ab [Titer] in Serum

126

2.44

3.74

1.4

1.3

400.00

487.50

titre

—

(3022948) Iron [Moles/volume] in Serum or Plasma

163

2.27

3.64

3.0

2.6

14.60

12.96

umol/l

0.39

150

(3004588) Protein electrophoresis panel - Serum or Plasma

2.85

3.46

2.7

2.4

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

167

2.21

3.43

2.3

2.8

1.03

1.28

e6/l

0.25

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

2.53

3.31

2.5

2.4

0.20

0.21

g/l

0.07

(3014765) Yersinia sp identified in Stool by Organism specific culture

3.90

3.17

1.4

1.3

—

(42529406) Shigella sp [Presence] in Stool by Culture

3.90

3.17

1.4

1.3

—

(40758558) Short blood count panel - Blood

268

1.96

3.11

8.5

6.0

—

(36304419) Bacteria [Presence] in Urine

293

1.94

3.11

3.1

3.0

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

10.32

3.00

1.8

1.2

25.60

31.40

umol/l

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

4.31

2.94

1.9

1.7

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

8.60

2.77

1.2

1.0

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

5.21

2.76

2.9

1.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

222

1.93

2.70

2.8

2.0

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

199

1.95

2.66

3.3

3.2

40.93

121.29

ng/l

0.91

152

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.50

2.60

2.1

1.7

—

(3045142) Bone marrow Pathology biopsy report

7.36

2.57

2.6

1.3

—

(3013512) EKG study

295

1.80

2.47

3.3

4.1

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

401

1.74

2.46

2.7

2.0

95.17

92.78

pmol/l

0.15

196

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

5.18

2.43

3.2

3.3

2.75

2.78

nmol/l

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.20

2.41

4.0

3.6

—

(3035637) Corticotropin [Mass/volume] in Plasma

6.44

2.39

1.8

2.9

—

(3037467) Urinalysis macro (dipstick) panel - Urine

684

1.74

2.34

5.4

4.0

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

160

1.95

2.33

2.6

1.8

28.59

29.42

0.43

153

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

3.25

2.27

2.3

1.7

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

3.25

2.27

1.2

1.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

154

1.95

2.26

1.8

1.9

—

(3042936) Bacteria identified in Isolate by Culture

139

1.99

2.25

1.7

2.1

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

5.72

2.23

1.0

2.3

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

5.72

2.23

1.0

2.3

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

5.72

2.23

1.0

2.3

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

457

1.67

2.19

4.2

4.3

35.28

35.49

g/l

0.11

432

(4035726) Immunohistochemistry procedure

2.18

1.2

1.3

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

4.43

2.17

1.0

1.8

—

(40760892) CBC W Ordered Manual Differential panel - Blood

497

1.66

2.14

9.5

5.5

—

(3019225) pH of Specimen

2.16

2.12

6.7

4.5

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

158

1.89

2.10

2.3

3.1

9.50

2.62

e6/l

0.69

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

4.14

2.06

1.2

1.1

—

(40760888) Immunoglobulin light chains.free panel - Serum

4.14

2.06

6.2

3.5

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

2.42

2.05

1.3

—

(3018095) Leukocytes [#/volume] in Urine

381

1.65

2.03

3.5

3.9

35.39

75.81

e6/l

0.75

284

(3021589) Normoblasts [#/volume] in Blood

475

1.62

1.99

11.3

9.5

0.00

e9/l

0.38

388

(3015377) Calcium [Moles/volume] in Serum or Plasma

348

1.65

1.96

3.0

3.2

2.33

2.36

mmol/l

1.45

307

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

3.87

1.96

1.0

1.7

—

(40761535) Cells panel - Urine sediment

2.17

1.95

8.8

4.3

—

(3027945) Reticulocytes/100 erythrocytes in Blood

124

1.93

1.90

6.3

2.4

1.77

1.68

0.13

110

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.97

1.89

1.5

1.3

—

(3030467) Casts [#/volume] in Urine by Automated count

298

1.66

1.88

3.3

3.2

0.35

0.38

e6/l

0.07

231

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

115

1025

1.95

1.80

20.2

14.2

20.76

25.02

mg/l

0.91

100

790

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

3.44

1.76

1.0

2.0

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

3.44

1.76

1.0

2.0

—

(3011288) Drugs identified in Urine by Screen method

2.77

1.75

3.3

2.1

—

(3022621) pH of Urine by Test strip

2.22

1.72

2.3

2.2

—

(3044640) Blood type and Crossmatch panel - Blood

314

1.60

1.69

3.7

2.2

—

(3044290) Cell count panel - Cerebral spinal fluid

3.26

1.68

1.2

1.1

—

(3028707) Methadone [Presence] in Urine by Screen method

3.26

1.68

2.0

1.9

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.31

1.62

1.9

1.6

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

165

1.72

1.55

1.6

1.2

20.23

34.00

iu/ml

—

(3000850) Epithelial cells [#/volume] in Urine

241

1.62

1.54

2.9

2.7

3.69

4.84

e6/l

0.41

219

(3004616) Nuclear Ab [Presence] in Serum

3.42

1.53

1.8

1.1

—

(1761868) Lipid panel - Serum or Plasma

361

0.59

1.52

2.3

3.0

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

115

1039

1.83

1.52

21.9

16.3

139.44

139.68

mmol/l

0.47

115

1010

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.47

1.49

1.4

1.6

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

105

928

1.64

1.48

5.2

4.4

2.09

1.99

mu/l

0.17

100

835

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.58

1.47

1.0

1.9

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.58

1.47

1.3

1.6

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

2.58

1.47

1.7

—

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

2.81

1.45

1.2

3.52

3.54

mmol/l

—

(3000991) Gas panel - Venous blood

1.91

1.45

6.7

6.0

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

115

1043

1.80

1.44

22.3

16.4

3.98

mmol/l

0.08

115

1014

(3026782) Osmolality of Urine

219

1.61

1.44

2.7

3.1

531.08

531.93

mosm/kgh2o

0.01

192

(3007164) IgA [Mass/volume] in Serum or Plasma

228

1.60

1.43

1.9

1.3

1.60

2.40

g/l

3.01

123

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.34

1.43

1.1

1.0

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

229

1.59

1.41

1.8

1.7

1.47

0.85

mg/l

0.72

182

(40768797) Stomach Pathology biopsy report

130

1.73

1.37

1.1

1.3

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.17

1.33

3.8

2.0

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

156

1.66

1.32

1.6

1.3

1.09

6.50

u/ml

1.15

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

2.84

1.29

1.0

1.3

—

(40761511) CBC panel - Blood by Automated count

116

1064

1.74

1.27

18.0

13.8

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.30

1.26

1.6

2.0

—

(3002582) Erythrocytes [#/volume] in Urine

334

1.48

1.24

3.3

3.4

11.11

262.36

e6/l

0.75

267

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

2.69

1.22

1.0

1.8

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

2.69

1.22

1.2

1.4

—

(40768804) Tissue Pathology biopsy report

373

1.45

1.20

2.3

2.1

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.93

1.18

1.1

1.2

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

1.18

0.0

1.6

—

225.08

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

136

1.65

1.17

7.6

6.2

1.14

1.08

mmol/l

0.56

126

(1001926) Buprenorphine [Presence] in Urine by Screen method

2.33

1.12

2.1

1.6

—

(3029937) Albumin [Presence] in Urine by Test strip

277

1.47

1.11

6.8

4.1

0.00

estimate

-0.00

(36660697) Celiac disease serology panel - Serum

1.79

1.10

1.2

1.1

—

(3035350) Ketones [Presence] in Urine by Test strip

504

1.39

1.06

4.9

3.8

0.00

0.01

estimate

0.50

108

(3012336) Haptoglobin [Mass/volume] in Serum or Plasma

1.98

1.04

2.4

1.6

1.58

1.51

g/l

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.96

1.04

1.4

1.3

62.90

151.44

u/ml

—

(3037756) Immunofixation for Serum or Plasma

2.32

1.04

2.2

1.3

—

(4200892) Spirometry reversibility

1.79

1.03

1.3

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

116

1078

1.63

1.01

22.5

16.4

80.28

78.98

umol/l

0.11

116

1078

(3016879) Cocaine [Presence] in Urine

2.05

1.01

2.1

1.7

—

(3022313) Gas panel - Capillary blood

1.90

1.01

5.9

4.2

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

469

1.38

1.00

2.7

2.4

—

(3021601) Nitrite [Presence] in Urine by Test strip

498

1.38

1.00

5.7

5.2

0.00

estimate

-0.00

101

(3011397) Hemoglobin [Presence] in Urine by Test strip

229

1.46

0.99

6.4

3.7

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.96

0.0

4.1

—

(3000764) Benzodiazepines [Presence] in Urine

1.94

0.95

2.1

1.7

—

(3028300) Cannabinoids [Presence] in Urine

1.94

0.95

2.1

1.7

—

(3027008) Opiates [Presence] in Urine

1.94

0.95

2.1

1.7

—

(3027944) Amphetamines [Presence] in Urine

1.94

0.95

2.1

1.7

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

689

1.37

0.95

3.8

2.9

55.50

44.77

u/l

0.49

647

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.20

0.93

1.0

1.9

—

(3023520) Reticulocytes [#/volume] in Blood

1.68

0.92

5.1

2.5

81.69

66.50

e9/l

0.82

(3009261) Glucose [Presence] in Urine by Test strip

505

1.34

0.89

5.1

3.9

0.00

estimate

-0.00

(3003327) Ova and parasites identified in Stool by Light microscopy

2.05

0.88

1.2

—

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

1.98

0.85

1.7

2.9

0.95

1.77

mg/l

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

103

946

1.40

0.84

17.7

13.4

82.85

79.99

ml/min/173m2

0.59

772

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.86

0.80

1.0

2.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

151

1.46

0.77

1.5

1.6

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

126

1.50

0.75

1.7

1.6

—

(3026008) Bacteria identified in Urine by Culture

334

1.33

0.74

4.2

2.8

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

110

1.52

0.72

1.9

1.8

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.59

0.72

1.3

1.6

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.88

0.69

1.6

1.4

—

(3044889) 12 lead EKG panel

699

1.28

0.68

4.1

4.0

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

112

1.49

0.67

1.8

1.7

—

(40768443) Skin Pathology biopsy report

1.75

0.64

1.2

—

(3052851) Hemolysis interference index of Serum or Plasma

1.75

0.64

3.4

2.8

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.64

0.64

1.8

1.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

131

1.43

0.63

14.1

8.6

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

304

1.30

0.63

2.8

3.4

370.33

1691.95

ng/l

4.69

255

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.69

0.62

1.2

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

1.69

0.62

1.6

1.8

0.89

2.86

mg/l

—

(3012516) Albumin [Mass/volume] in Urine

277

1.31

0.61

2.9

3.0

36.87

281.65

mg/l

0.55

179

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.58

0.61

1.5

1.6

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

259

1.31

0.60

1.6

1.3

8.36

0.75

u/ml

0.45

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

195

1.35

0.60

3.3

2.8

2.47

2.45

mmol/l

0.30

175

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.55

0.58

1.4

1.9

—

(3002385) Erythrocyte distribution width [Ratio]

904

1.28

0.56

23.8

16.8

15.31

14.87

0.30

889

(3025941) Bacteria identified in Stool by Culture

1.51

0.55

1.6

1.2

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

115

1097

1.38

0.54

13.2

9.8

24.97

25.48

u/l

0.14

115

1057

(40761536) Microorganisms panel - Urine sediment

1.45

0.49

4.0

3.5

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

129

1.36

0.49

6.2

5.7

106.12

104.24

mmol/l

0.66

129

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

401

1.23

0.47

5.8

4.0

—

(3027801) Oxygen [Partial pressure] in Arterial blood

122

1.35

0.45

5.5

6.1

12.95

11.95

kpa

0.40

116

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

122

1.35

0.45

5.5

6.1

5.33

5.09

kpa

0.32

116

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

984

0.81

0.45

5.0

4.5

5.90

5.92

mmol/l

0.05

888

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.58

0.42

2.2

1.3

—

(3025159) Blasts/100 leukocytes in Blood

1.43

0.42

2.6

4.0

0.40

0.31

—

(21494755) Public health laboratory ask at order entry panel

101

0.68

0.41

1.1

1.5

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.41

0.0

3.6

—

59.50

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.41

0.0

2.8

—

(40768806) Pleura Pathology biopsy report

0.00

0.41

0.0

1.9

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.41

0.0

1.0

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.41

0.0

2.7

—

107.18

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.41

0.0

2.7

—

4.11

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.41

0.0

1.4

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.41

0.0

1.1

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.39

0.0

1.3

—

(3045414) Leukocytes [Presence] in Urine

1.40

0.38

1.4

2.0

—

(3002256) Pathology report gross observation

108

1.33

0.37

1.4

1.3

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

996

0.84

0.36

5.5

5.0

2.71

2.67

mmol/l

0.17

911

(3020891) Body temperature

1.41

0.35

5.3

4.0

—

(3022145) Colonoscopy Study observation

118

1.31

0.35

1.7

1.3

—

(3016502) Oxygen saturation in Arterial blood

110

1.31

0.33

5.9

6.4

95.70

95.65

0.01

105

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

110

1.31

0.33

2.5

2.3

—

(3017181) Myelocytes/100 leukocytes in Blood

1.33

0.33

2.6

3.8

1.67

0.87

—

(3007461) Platelets [#/volume] in Blood

117

1137

1.26

0.30

31.3

20.5

237.77

242.86

e9/l

0.36

117

1108

(3026361) Erythrocytes [#/volume] in Blood

117

1139

1.24

0.27

31.4

20.5

4.38

4.48

e12/l

1.35

117

1106

(3009542) Hematocrit [Volume Fraction] of Blood

117

1139

1.24

0.27

31.6

20.4

39.08

40.16

1.94

111

1069

(3024731) MCV [Entitic volume]

117

1139

1.24

0.27

31.2

20.4

90.52

90.79

0.24

117

1120

(3000963) Hemoglobin [Mass/volume] in Blood

117

1139

1.24

0.27

31.4

20.6

130.04

134.73

g/l

2.85

117

1119

(3035941) MCH [Entitic mass]

117

1139

1.24

0.27

31.2

20.4

30.08

30.24

0.39

117

1120

(3010813) Leukocytes [#/volume] in Blood

117

1140

1.23

0.26

31.3

20.5

6.85

6.58

e9/l

0.71

117

1105

(3049717) Cytology report of Urine Cyto stain

1.23

0.22

4.0

2.9

—

(3000494) Fungus identified in Specimen by Culture

117

1.22

0.21

1.0

1.4

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.21

0.0

1.3

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

0.21

0.0

1.3

—

10.09

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.3

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.3

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.21

0.0

5.3

—

(3011648) Oxygen content in Venous blood

0.00

0.21

0.0

2.1

—

11.25

—

(3035880) pH of Pleural fluid

0.00

0.21

0.0

1.0

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.4

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

(4146454) Self-monitoring of blood glucose

0.00

0.21

0.0

3.3

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

972

0.89

0.21

4.7

4.5

4.46

4.56

mmol/l

0.43

899

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

4.5

—

137.28

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.4

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.23

0.20

3.3

2.6

0.52

0.69

—

(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum

0.00

0.20

0.0

1.0

—

1.49

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.20

0.0

1.3

—

156.19

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.21

0.20

3.3

2.6

2.12

1.02

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

206

0.85

0.20

3.8

3.0

0.84

0.93

ug/l

0.15

124

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

143

0.82

0.20

1.3

1.4

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

941

0.89

0.19

4.2

4.0

1.26

mmol/l

0.01

857

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

282

1.13

0.19

5.2

4.5

20.91

22.24

0.19

127

(3020682) Albumin/Creatinine [Ratio] in Urine

293

1.12

0.17

3.6

5.63

7.52

mg/mmol

0.25

182

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

964

0.91

0.14

4.6

4.5

1.38

1.46

mmol/l

0.88

881

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

927

1.09

0.12

6.3

5.6

39.15

40.14

mmol/mol

0.46

862

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.12

0.09

9.5

6.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

185

1.10

0.09

2.0

1.9

—

(3041096) Erythrocytes [Presence] in Urine by Automated

296

0.93

0.08

3.1

3.5

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

100

0.89

0.06

1.4

1.6

—

(3003694) ABO and Rh group [Type] in Blood

267

1.06

0.06

1.3

1.4

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

103

1.07

0.02

2.9

2.1

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

662

1.02

0.01

3.1

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

176

0.96

0.00

2.9

1.5

—

(3003338) MCHC [Mass/volume]

871

1.00

0.00

29.1

17.7

331.61

332.60

g/l

0.51

866

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

0.0

3.7

—

4.59

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.3

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

2.7

—

13.78

—

(3009306) Alpha-1-Fetoprotein [Mass/volume] in Serum or Plasma

0.00

0.0

3.2

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

5.7

—

241.17

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

0.95

0.00

4.9

4.2

130.75

85.59

ng/l

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

0.31

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

1023.60

—

(3051651) Icteric interference index of Serum or Plasma

0.00

-0.00

0.0

3.2

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.4

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(3000492) Spirometry study

1.00

-0.00

1.8

1.5

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

3.4

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3012741) Chlamydophila pneumoniae IgA Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

-0.00

0.0

1.3

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

93.98

—

(3000330) Specific gravity of Urine by Test strip

0.96

-0.00

1.4

3.8

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

0.97

-0.00

2.1

2.3

34.30

14.04

nmol/l

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

3.4

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

1.2

—

(3020485) Acetaminophen [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

-0.00

0.0

1.0

—

(3043410) Blood group antigens tested for on Red Blood Cells

0.00

-0.00

0.0

1.0

—

(3011544) Albumin [Mass/volume] in Pleural fluid

0.00

-0.00

0.0

1.0

—

18.60

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.4

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.99

-0.00

1.7

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.98

-0.00

1.0

1.1

—

(40768441) Liver Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

207.44

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

-0.00

0.0

2.0

—

1.62

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.1

—

(3019060) Gas panel - Arterial blood

0.93

-0.00

3.0

4.1

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.5

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_IDIOAUT and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_IDIOAUT	2.777 [2.01, 3.83]	< 0.001
Birth year	0.994 [0.98, 1.01]	0.307

During the follow-up period (1.1.1998 — 31.12.2019), 116 out of 349 females with G6_IDIOAUT died.

Males

Parameter	HR [95% CI]	p-value
G6_IDIOAUT	1.888 [1.43, 2.49]	< 0.001
Birth year	0.986 [0.98, 1.0]	0.003

During the follow-up period (1.1.1998 — 31.12.2019), 150 out of 429 males with G6_IDIOAUT died.

Mortality risk

Mortality risk for people of age

years, who have G6_IDIOAUT.

N-year risk	Females	Males
1	0.284%	0.399%
5	1.651%	2.298%
10	4.088%	5.4%
15	7.869%	10.144%
20	13.603%	17.063%

Relationships between endpoints

↥

Index endpoint: G6_IDIOAUT – Idiopathic peripheral autonomic neuropathy

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Idiopathic peripheral autonomic neuropathy

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints