Idiopathic peripheral autonomic neuropathy

G6_IDIOAUT

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G90.0 Hospital discharge: ICD-9 — 3370 Cause of death: ICD-10 — G90.0 Cause of death: ICD-9 — 3370 2 out of 7 registries used, show all original rules.	121
4. Check minimum number of events None	121
5. Include endpoints None	121
6. Filter based on genotype QC (FinnGen only)	121

Control definitions (FinnGen only)

Control exclude: G6_AUTONOM

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: G90
Name in latin: Neuropathia autonomica peripherica idiopathica

NAME	G6_IDIOAUT
CONTROL_EXCLUDE	G6_AUTONOM
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G900
HD_ICD_9	3370
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G900
COD_ICD_9	3370
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Idiopathic peripheral autonomic neuropathy based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	941	432	497
Only index persons	774	372	402
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.02
Median age at first event (years)
Whole population	57.97	60.25	55.86
Only index persons	55.19	57.82	52.76

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	121	61	60
Unadjusted period prevalence (%)	0.02	0.02	0.03
Median age at first event (years)	62.44	59.91	65.02

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
109: Matched controls
1087

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G90.0

ICD-10 Finland

Idiopathic peripheral autonomic neuropathy

+∞

154.2

108

R55

ICD-10 Finland

Syncope and collapse

11.2

21.3

I49.5

ICD-10 Finland

Sick sinus syndrome

19.3

12.2

AA1AD

NOMESCO Finland

CT of head and brain

3.8

8.6

165

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

6.7

7.7

FPE20

NOMESCO Finland

Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes

8.7

6.9

XFP20

NOMESCO Finland

Check up of cardiac pacemaker

5.6

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

477

2.79

6.77

5.9

6.7

1.21

mmol/l

0.35

393

(3018418) pH of Serum or Plasma

292

2.71

6.65

3.3

4.0

7.40

0.13

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

435

2.53

5.83

5.7

5.3

1.21

mmol/l

0.45

376

(3032080) INR in Blood by Coagulation assay

382

2.43

5.45

7.1

8.2

1.17

1.22

inr

0.17

119

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

343

2.25

4.55

3.8

3.5

—

(3023368) Bacteria identified in Blood by Culture

253

2.32

4.54

3.5

4.3

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

4.55

4.46

1.4

1.3

—

(42529406) Shigella sp [Presence] in Stool by Culture

4.55

4.46

1.4

1.3

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

7.38

4.24

1.9

1.6

—

(3007853) Bacteria identified in Skin by Aerobe culture

101

2.72

4.14

1.8

1.7

—

(3004588) Protein electrophoresis panel - Serum or Plasma

3.03

3.77

2.7

2.5

—

(3019309) Folate [Moles/volume] in Red Blood Cells

186

2.24

3.65

1.8

1168.55

1201.68

nmol/l

0.07

139

(3022948) Iron [Moles/volume] in Serum or Plasma

151

2.31

3.55

2.5

2.7

14.87

12.95

umol/l

0.44

139

(40758558) Short blood count panel - Blood

243

2.12

3.54

8.9

6.3

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

137

2.36

3.53

2.3

2.8

2.41

2.31

g/l

0.51

124

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

152

2.29

3.49

2.3

2.9

1.08

1.27

e6/l

0.16

(3037522) Nuclear Ab [Titer] in Serum

118

2.41

3.40

1.4

1.3

413.33

487.50

titre

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

202

2.11

3.25

2.6

2.0

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

2.52

3.14

2.4

0.20

g/l

0.05

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

184

2.09

3.01

3.4

3.3

42.19

121.39

ng/l

0.84

145

(36304419) Bacteria [Presence] in Urine

267

1.95

2.91

3.2

3.1

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.71

2.83

1.7

1.8

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

5.23

2.77

2.9

1.4

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

6.24

2.73

3.2

3.6

2.75

3.12

nmol/l

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

2.85

2.72

1.3

1.4

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

378

1.83

2.68

4.3

3.8

20.90

37.06

ng/l

1.57

274

(3045142) Bone marrow Pathology biopsy report

7.39

2.57

2.6

1.3

—

(3035637) Corticotropin [Mass/volume] in Plasma

7.39

2.57

1.8

2.0

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

148

2.06

2.55

2.6

1.8

28.57

29.53

0.49

141

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

3.65

2.54

1.2

1.3

—

(42870588) Differential panel, method unspecified - Blood

314

1.81

2.48

8.5

4.5

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

379

1.77

2.40

2.7

2.0

94.89

93.21

pmol/l

0.10

184

(3024561) Albumin [Mass/volume] in Serum or Plasma

428

1.74

2.31

3.8

4.3

35.26

35.35

g/l

0.04

403

(4035726)

2.26

2.31

1.2

1.3

—

(3044640) Blood type and Crossmatch panel - Blood

285

1.79

2.30

3.6

2.2

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

4.79

2.30

1.0

1.5

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

4.79

2.30

1.0

1.5

—

(40760888) Immunoglobulin light chains.free panel - Serum

4.15

2.06

6.2

3.5

—

(3018095) Leukocytes [#/volume] in Urine

348

1.69

2.01

3.6

4.1

38.50

82.03

e6/l

0.74

259

(3037467) Urinalysis macro (dipstick) panel - Urine

627

1.69

1.98

5.4

4.2

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

3.10

1.97

2.4

1.9

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

146

1.90

1.97

2.3

3.3

10.13

2.65

e6/l

0.71

(3044290) Cell count panel - Cerebral spinal fluid

3.89

1.96

1.2

1.1

—

(3042936) Bacteria identified in Isolate by Culture

131

1.93

1.95

1.5

2.0

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.78

1.91

1.1

1.0

—

(40761535) Cells panel - Urine sediment

2.20

1.90

8.7

4.0

—

(3027945) Reticulocytes/100 erythrocytes in Blood

117

1.96

1.89

6.0

2.5

1.75

1.69

0.07

104

(3028707) Methadone [Presence] in Urine by Screen method

3.66

1.86

2.0

1.6

—

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

3.45

1.77

1.2

3.52

mmol/l

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

144

1.83

1.74

1.9

1.8

—

(3019225) pH of Specimen

2.07

1.74

4.1

4.6

—

(36660697) Celiac disease serology panel - Serum

2.16

1.72

1.2

1.1

—

(3007164) IgA [Mass/volume] in Serum or Plasma

202

1.72

1.71

2.0

1.3

1.60

2.44

g/l

2.88

113

(3021589) Normoblasts [#/volume] in Blood

426

1.59

1.69

11.7

9.6

0.00

e9/l

0.38

345

(3030467) Casts [#/volume] in Urine by Automated count

272

1.64

1.67

3.4

3.3

0.35

0.40

e6/l

0.09

211

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.27

1.67

1.1

1.3

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

3.68

1.63

1.2

1.1

—

(3022621) pH of Urine by Test strip

2.23

1.61

1.9

2.3

—

(3011288) Drugs identified in Urine by Screen method

2.79

1.60

3.6

1.9

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.79

1.60

1.4

1.3

—

(1761868) Lipid panel - Serum or Plasma

329

0.56

1.59

2.5

3.0

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

3.43

1.54

1.0

1.4

—

(3004616) Nuclear Ab [Presence] in Serum

3.43

1.54

1.8

1.1

—

(3000991) Gas panel - Venous blood

2.00

1.52

6.9

6.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.92

1.52

4.4

3.6

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

323

1.57

1.51

2.8

3.3

2.32

2.36

mmol/l

1.27

280

(3005322) IgE [Units/volume] in Serum or Plasma

2.33

1.51

1.4

1.3

62.90

165.69

u/ml

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

426

1.53

1.49

3.5

4.0

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

144

1.74

1.45

1.6

1.3

1.09

6.85

u/ml

1.15

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

104

934

1.81

1.45

20.8

14.4

21.65

24.64

mg/l

0.51

726

(3000850) Epithelial cells [#/volume] in Urine

220

1.62

1.44

3.0

2.8

4.02

4.99

e6/l

0.29

196

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

153

1.71

1.43

1.7

1.2

20.23

35.66

iu/ml

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.29

1.40

3.8

2.0

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

206

1.61

1.35

1.9

1.7

1.34

0.86

mg/l

0.50

168

(3026782) Osmolality of Urine

198

1.61

1.34

2.8

3.0

522.90

538.46

mosm/kgh2o

0.13

173

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.18

1.32

2.0

1.5

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

2.85

1.30

1.0

1.6

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

2.85

1.30

1.2

1.3

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

126

1.70

1.24

5.2

6.6

1.11

1.06

mmol/l

0.64

116

(3013512) EKG study

272

1.52

1.24

3.4

4.1

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.24

1.24

1.5

1.6

—

(40768797) Stomach Pathology biopsy report

118

1.72

1.24

1.2

1.3

—

(4010399)

1.97

1.23

1.2

1.3

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.37

1.20

1.0

1.7

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.37

1.20

1.0

1.7

—

(3015736) pH of Urine

348

1.47

1.18

5.5

3.7

—

(3002582) Erythrocytes [#/volume] in Urine

304

1.47

1.14

3.4

3.5

11.66

284.26

e6/l

0.73

243

(3037756) Immunofixation for Serum or Plasma

2.44

1.10

2.2

1.3

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

104

956

1.63

1.04

22.4

16.6

139.44

139.68

mmol/l

0.45

104

928

(3011397) Hemoglobin [Presence] in Urine by Test strip

210

1.50

1.03

6.7

3.5

—

(3035350) Ketones [Presence] in Urine by Test strip

462

1.39

1.00

5.1

3.8

0.00

estimate

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

104

959

1.60

0.99

22.9

16.8

3.97

3.98

mmol/l

0.22

104

931

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.99

0.0

1.5

—

221.16

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.99

0.0

4.2

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

2.28

0.95

1.5

1.7

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.28

0.95

1.3

1.7

—

(3003327) Ova and parasites identified in Stool by Light microscopy

2.28

0.95

1.2

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

2.28

0.95

2.2

1.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

103

1.64

0.93

1.9

1.8

—

(3012544) pH of Venous blood

1.64

0.89

3.0

3.8

—

(3012336) Haptoglobin [Mass/volume] in Serum or Plasma

1.92

0.89

2.4

1.7

1.52

1.56

g/l

—

(40761511) CBC panel - Blood by Automated count

105

976

1.57

0.89

18.1

14.1

—

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

2.05

0.88

1.7

2.9

0.95

1.78

mg/l

—

(3016879) Cocaine [Presence] in Urine

2.05

0.88

2.2

1.4

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.82

0.86

1.8

1.4

—

(3027008) Opiates [Presence] in Urine

1.98

0.85

2.2

1.4

—

(3000764) Benzodiazepines [Presence] in Urine

1.98

0.85

2.2

1.4

—

(3028300) Cannabinoids [Presence] in Urine

1.98

0.85

2.2

1.5

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.68

0.85

2.6

4.2

1.22

mmol/l

0.02

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.71

0.85

1.3

1.6

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

228

1.42

0.84

1.6

1.3

9.09

0.76

u/ml

0.45

(3020564) Creatinine [Moles/volume] in Serum or Plasma

106

991

1.56

0.83

23.3

16.6

75.92

79.34

umol/l

1.13

106

991

(3027944) Amphetamines [Presence] in Urine

1.92

0.83

2.2

1.4

—

(3023520) Reticulocytes [#/volume] in Blood

1.66

0.82

4.6

2.5

82.20

65.73

e9/l

0.83

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

124

1.53

0.81

1.4

1.5

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.80

0.77

1.8

1.9

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

2.22

0.77

1.6

1.4

—

(3029937) Albumin [Presence] in Urine by Test strip

251

1.37

0.75

7.4

4.1

0.00

estimate

—

(40768804) Tissue Pathology biopsy report

345

1.33

0.73

2.3

2.1

—

(3021601) Nitrite [Presence] in Urine by Test strip

460

1.31

0.73

5.9

5.2

0.00

estimate

—

(3052851) Hemolysis interference index of Serum or Plasma

2.04

0.73

3.4

3.1

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

119

1.50

0.71

14.1

8.3

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

1.96

0.71

1.6

1.8

0.89

3.01

mg/l

—

(21494755) Public health laboratory ask at order entry panel

0.52

0.70

1.0

1.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

111

1.51

0.70

1.4

1.5

—

(3022313) Gas panel - Capillary blood

1.71

0.69

5.1

4.5

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.89

0.69

1.2

—

(40768443) Skin Pathology biopsy report

1.89

0.69

1.2

—

(3026008) Bacteria identified in Urine by Culture

303

1.32

0.65

4.4

2.9

—

(3009261) Glucose [Presence] in Urine by Test strip

466

1.29

0.65

5.3

3.8

0.00

estimate

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.64

0.64

1.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

105

1.49

0.63

1.9

1.7

—

(3002385) Erythrocyte distribution width [Ratio]

790

1.31

0.62

25.7

17.5

13.91

13.65

0.97

773

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.69

0.62

1.0

2.5

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

914

0.76

0.62

5.0

4.5

5.91

5.93

mmol/l

0.04

822

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

187

1.35

0.59

3.0

2.8

2.47

2.45

mmol/l

0.21

167

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

630

1.26

0.58

3.8

2.9

60.28

45.34

u/l

0.67

590

(3014111) Lactate [Moles/volume] in Serum or Plasma

1.50

0.58

6.6

4.8

1.23

1.31

mmol/l

0.14

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

116

1.44

0.58

5.5

6.2

5.33

5.09

kpa

0.32

110

(3027801) Oxygen [Partial pressure] in Arterial blood

116

1.44

0.58

5.5

6.2

12.95

11.91

kpa

0.41

110

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

1.46

0.54

4.1

4.3

5.01

5.06

kpa

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

871

1.29

0.52

18.4

13.6

83.04

78.93

ml/min/173m2

0.97

715

(3020891) Body temperature

1.53

0.52

5.3

3.9

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

926

0.78

0.52

5.7

5.1

2.75

2.68

mmol/l

0.31

843

(3012516) Albumin [Mass/volume] in Urine

269

1.26

0.46

2.8

2.9

38.19

288.08

mg/l

0.53

172

(3025941) Bacteria identified in Stool by Culture

1.46

0.43

1.5

1.2

—

(3016502) Oxygen saturation in Arterial blood

105

1.38

0.43

5.9

6.4

95.70

95.59

0.02

100

(3045414) Leukocytes [Presence] in Urine

1.54

0.42

1.4

2.1

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.41

0.0

2.8

—

107.27

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.41

0.0

2.8

—

4.09

—

(40768806) Pleura Pathology biopsy report

0.00

0.41

0.0

2.0

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.41

0.0

1.4

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.41

0.0

3.6

—

59.38

—

(3044889) 12 lead EKG panel

655

1.20

0.41

4.1

4.0

—

(3008401) Mugwort IgE Ab [Units/volume] in Serum

0.00

0.41

0.0

1.1

—

0.40

—

(3003888) Timothy IgE Ab [Units/volume] in Serum

0.00

0.41

0.0

1.1

—

4.04

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

369

1.21

0.41

6.0

3.9

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.40

0.0

1.3

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

105

1009

1.31

0.39

13.3

9.9

25.67

25.45

u/l

0.05

105

970

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.61

0.36

1.0

1.5

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.32

0.33

3.3

2.6

2.12

1.02

—

(3017181) Myelocytes/100 leukocytes in Blood

1.34

0.31

2.7

3.4

1.67

0.96

—

(3002256) Pathology report gross observation

103

1.29

0.29

1.4

1.3

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.31

0.27

1.5

2.1

—

(40760892) CBC W Ordered Manual Differential panel - Blood

227

1.19

0.26

7.5

4.3

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.65

0.26

1.4

1.9

—

(40761536) Microorganisms panel - Urine sediment

1.20

0.25

4.0

3.7

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

189

0.82

0.24

3.6

3.0

0.79

0.94

ug/l

0.24

113

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

258

1.16

0.24

5.1

4.3

20.44

22.27

0.26

112

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

874

0.87

0.23

4.3

4.1

1.28

1.25

mmol/l

0.17

793

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

902

0.87

0.22

4.8

4.6

4.48

4.57

mmol/l

0.32

831

(3049717) Cytology report of Urine Cyto stain

1.23

0.22

4.0

2.9

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

0.21

0.0

1.3

—

10.09

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.21

0.0

1.7

—

(3011648) Oxygen content in Venous blood

0.00

0.21

0.0

2.1

—

11.25

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.4

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.21

0.0

1.3

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.21

0.0

5.6

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.0

—

(4146454)

0.00

0.21

0.0

3.3

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.21

0.0

1.3

—

147.55

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

4.5

—

137.28

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.20

0.0

2.9

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.20

0.0

1.1

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.20

0.0

1.1

—

(3000492) Spirometry study

1.12

0.15

1.8

1.5

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

894

0.90

0.15

4.6

1.39

1.46

mmol/l

0.78

813

(3007461) Platelets [#/volume] in Blood

106

1041

1.15

0.13

32.3

20.7

238.25

242.70

e9/l

0.28

106

1013

(46235355) HIV 1 and 2 tests - Meaningful Use set

152

1.14

0.13

1.9

1.8

—

(3041096) Erythrocytes [Presence] in Urine by Automated

271

0.90

0.13

3.0

3.6

—

(3003694) ABO and Rh group [Type] in Blood

230

1.11

0.13

1.3

—

(3024731) MCV [Entitic volume]

106

1042

1.14

0.12

32.2

20.6

90.61

90.88

0.23

106

1023

(3026361) Erythrocytes [#/volume] in Blood

106

1042

1.14

0.12

32.4

20.6

4.37

4.48

e12/l

1.32

106

1010

(3035941) MCH [Entitic mass]

106

1042

1.14

0.12

32.1

20.6

30.12

30.25

0.29

106

1023

(3000963) Hemoglobin [Mass/volume] in Blood

106

1042

1.14

0.12

32.4

20.7

129.90

134.66

g/l

2.68

106

1022

(3010813) Leukocytes [#/volume] in Blood

106

1042

1.14

0.12

32.4

20.8

6.77

6.53

e9/l

0.62

106

1008

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

124

0.88

0.09

1.2

1.3

—

(3000330) Specific gravity of Urine by Test strip

1.04

0.09

1.4

3.9

—

(3020682) Albumin/Creatinine [Ratio] in Urine

283

1.08

0.09

3.3

3.7

5.77

6.71

mg/mmol

0.11

174

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.14

0.09

9.5

6.5

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.10

0.09

1.0

1.1

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

0.86

0.07

1.9

4.4

63.29

87.15

ng/l

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

863

0.95

0.05

6.3

5.7

39.41

40.29

mmol/mol

0.36

800

(3009542) Hematocrit [Volume Fraction] of Blood

853

1.03

0.01

24.2

14.3

38.69

40.08

0.86

613

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

587

0.98

0.01

3.0

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

146

1.03

0.00

2.5

1.5

—

(3035880) pH of Pleural fluid

0.00

0.0

1.0

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.1

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.1

—

(3009306) Alpha-1-Fetoprotein [Mass/volume] in Serum or Plasma

0.00

0.0

3.2

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.3

—

(3020485) Acetaminophen [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

2.0

—

1023.60

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

0.97

0.00

2.0

2.1

37.33

14.40

nmol/l

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

0.34

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.99

0.00

1.6

1.9

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.92

0.00

1.7

1.6

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

0.0

2.0

—

1.62

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.0

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

3.0

—

13.94

—

(3012741) Chlamydophila pneumoniae IgA Ab [Titer] in Serum

0.00

0.0

1.0

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.0

1.0

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.0

2.3

—

(3000494) Fungus identified in Specimen by Culture

110

1.00

0.00

1.0

1.4

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.1

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

5.7

—

241.17

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.3

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

3.2

—

(3011544) Albumin [Mass/volume] in Pleural fluid

0.00

0.0

1.0

—

18.60

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

0.0

1.0

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.6

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.3

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.4

—

(3019060) Gas panel - Arterial blood

0.99

0.00

3.0

4.1

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.9

—

(3022145) Colonoscopy Study observation

110

1.00

0.00

1.8

1.3

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_IDIOAUT and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_IDIOAUT	2.777 [2.01, 3.83]	< 0.001
Birth year	0.994 [0.98, 1.01]	0.307

During the follow-up period (1.1.1998 — 31.12.2019), 116 out of 349 females with G6_IDIOAUT died.

Males

Parameter	HR [95% CI]	p-value
G6_IDIOAUT	1.888 [1.43, 2.49]	< 0.001
Birth year	0.986 [0.98, 1.0]	0.003

During the follow-up period (1.1.1998 — 31.12.2019), 150 out of 429 males with G6_IDIOAUT died.

Mortality risk

Mortality risk for people of age

years, who have G6_IDIOAUT.

N-year risk	Females	Males
1	0.284%	0.399%
5	1.651%	2.298%
10	4.088%	5.4%
15	7.869%	10.144%
20	13.603%	17.063%

Relationships between endpoints

↥

Index endpoint: G6_IDIOAUT – Idiopathic peripheral autonomic neuropathy

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Idiopathic peripheral autonomic neuropathy

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints