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Horner syndrome

DOID EFO Endpoint Browser PheWeb

G6_HORNER

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G90.2
  • Hospital discharge: ICD-8 — 35800
  • Cause of death: ICD-10 — G90.2
  • Cause of death: ICD-8 — 35800

2 out of 7 registries used, show all original rules.

438

4. Check minimum number of events

None

438

5. Include endpoints

None

438

6. Filter based on genotype QC (FinnGen only)

438

Control definitions (FinnGen only)

Control exclude
G6_AUTONOM

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G90
Name in latin
Syndroma Horner

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2743 1372 1366
Only index persons 2515 1258 1257
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.04
Only index persons 0.05 0.05 0.05
Median age at first event (years)
Whole population 52.54 54.09 50.94
Only index persons 52.78 54.46 51.10

-FinnGen-

Key figures

All Female Male
Number of individuals 438 242 196
Unadjusted period prevalence (%) 0.08 0.08 0.09
Median age at first event (years) 55.53 55.55 55.49

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
401
Matched controls
4010
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G90.2
ICD-10 Finland
Horner syndrome
+∞
323.0
394
*
H02.4
ICD-10 Finland
Ptosis of eyelid
13.6
34.0
60
51
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
9.3
29.2
63
79
H57.0
ICD-10 Finland
Anomalies of pupillary function
59.7
28.6
33
6
I67.0
ICD-10 Finland
Dissection of cerebral arteries, nonruptured
96.3
25.0
27
*
AA1AD
NOMESCO Finland
CT of head and brain
3.4
24.7
148
582
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.8
21.0
222
1239
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
14.1
20.6
35
27
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.8
19.1
67
160
PA6CG
NOMESCO Finland
Extensive MRI examination of neck vasculature with high intensity magnet
30.0
15.3
20
7
G44.0
ICD-10 Finland
Cluster headache syndrome
21.1
15.3
22
11
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.9
13.6
58
166
XCK00
NOMESCO Finland
Perimetry
4.3
13.0
49
125
XCK10
NOMESCO Finland
Photography of fundus of eye
3.4
12.6
63
206
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
8.3
11.5
25
32
CBJ40
NOMESCO Finland
Resection of levator muscle of eyelid
16.1
10.9
17
11
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.6
10.6
83
363
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
5.8
9.8
27
49
B01AA03
ATC
warfarin; systemic
2.3
9.4
92
451
N03AX16
ATC
pregabalin; oral
2.2
9.2
114
624
PA6BG
NOMESCO Finland
MRI examination of neck vasculature with high intensity magnet
19.1
9.0
13
7
I63.2
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
19.1
9.0
13
7
35800
ICD-8 Finland
Disease of peripheral autonomic nervous system, Syndroma Horner
+∞
8.4
8
*
R51.80
ICD-10 Finland
Headache
2.4
8.2
70
319
N06AX21
ATC
duloxetine; oral
2.8
8.2
54
210
TAB00
NOMESCO Finland
Lumbar puncture
4.3
8.2
29
71
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.5
7.6
35
108
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
9.1
7.6
15
17
N02AX02
ATC
tramadol; systemic, rectal
1.8
7.6
182
1259
WX002
NOMESCO Finland
Sedation and analgesia
2.1
7.5
92
497
PA6AD
NOMESCO Finland
CT of neck arteries
7.9
7.5
16
21
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
3.4
7.4
35
110
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.6
7.4
54
227
PA7BD
NOMESCO Finland
CT angiography of neck and brain
7.5
7.3
16
22
Q13.2
ICD-10 Finland
Other congenital malformations of iris
30.6
7.2
9
*
C08DA01
ATC
verapamil; systemic
3.8
7.1
29
81
R42
ICD-10 Finland
Dizziness and giddiness
2.1
7.0
92
506
N02BE01
ATC
paracetamol; systemic, rectal
2.0
6.7
340
2943
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
12.5
6.6
11
9
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
2.4
6.5
54
242
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
4.8
6.5
20
43
CBJ41
NOMESCO Finland
Shortening of superior tarsal muscle (Müller's muscle)
70.9
6.4
7
*
ZXA10
NOMESCO Finland
Bilateral
2.1
6.4
81
440
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
11.3
6.3
11
10
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.1
6.3
33
113
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
3.1
6.3
32
108
WX110
NOMESCO Finland
Local anesthesy
1.7
6.1
269
2181
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.2
6.0
29
94

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
224
1396
2.24
15.21
8.1
8.6
1.3
1.2
inr
0.31
57
420
239
1584
2.12
13.26
6.9
6.2
1.2
1.2
mmol/l
0.95
220
1445
185
1160
2.03
11.44
6.7
5.7
—
—
—
0
0
174
1070
2.04
11.34
2.4
2.0
186.8
268.5
u/l
0.57
164
1007
248
1729
2.00
11.30
8.6
7.0
1.2
1.2
mmol/l
0.08
206
1467
286
2102
2.04
11.15
5.8
4.9
6.5
6.7
mmol/l
0.67
274
1957
148
882
2.02
10.34
5.0
3.7
91.3
91.6
%
0.07
148
865
242
1723
1.90
9.84
7.3
5.8
26.2
28.1
%
2.05
227
1614
255
1851
1.90
9.72
6.8
5.9
0.2
0.2
e9/l
0.31
229
1637
235
1685
1.85
9.07
7.5
6.0
8.8
8.6
%
0.56
223
1587
234
1677
1.85
9.04
7.2
5.7
3.0
2.9
%
0.24
220
1566
245
1786
1.84
8.91
6.8
5.6
0.6
0.6
e9/l
2.25
213
1553
250
1838
1.84
8.80
6.7
5.6
1.8
1.9
e9/l
1.06
224
1632
227
1622
1.83
8.76
7.3
5.7
0.7
0.7
%
0.24
216
1520
236
1709
1.83
8.69
7.2
5.6
58.3
56.9
%
1.02
223
1612
245
1797
1.82
8.62
6.8
5.6
0.0
0.0
e9/l
0.27
215
1563
271
2082
1.79
7.85
9.8
9.0
4.5
4.0
e9/l
1.87
240
1834
327
2673
1.88
7.57
5.5
4.1
12.7
11.7
mm/h
0.45
312
2463
208
1499
1.74
7.38
6.2
4.8
35.2
35.7
g/l
0.68
191
1393
160
1075
1.77
7.23
5.0
4.0
7.4
7.4
ph
2.65
35
206
144
948
1.77
6.92
4.3
4.2
—
—
—
0
0
380
3302
2.14
6.90
6.1
4.6
1.8
2.2
mu/l
0.59
354
3017
135
875
1.78
6.83
7.1
6.6
—
—
—
0
0
332
2768
1.82
6.70
10.2
7.6
81.9
78.0
u/l
0.55
314
2595
411
3714
2.73
6.40
22.2
15.8
4.0
4.0
mmol/l
1.04
402
3608
410
3703
2.68
6.35
22.1
15.7
139.6
139.7
mmol/l
0.18
402
3600
109
680
1.80
6.20
4.3
3.7
95.5
322.3
ng/l
1.63
85
518
22
68
3.35
6.08
2.0
2.4
17.2
16.2
%
—
10
30
166
1175
1.66
5.96
3.4
3.4
2.3
2.4
mmol/l
1.11
145
1038
71
395
1.95
5.74
6.3
9.2
0.8
1.2
mmol/l
0.30
57
323
295
2435
1.65
5.55
4.8
4.2
—
—
—
0
0
80
469
1.86
5.51
2.7
2.2
21.1
23.4
%
0.78
72
401
216
1662
1.59
5.38
4.2
4.1
—
—
—
0
0
169
1227
1.61
5.36
3.8
3.5
63.7
65.9
e6/l
0.03
115
873
320
2717
1.66
5.18
5.2
3.8
15.0
14.8
pmol/l
0.66
298
2463
156
1123
1.60
5.07
2.6
2.3
—
—
—
0
0
53
278
2.03
5.05
8.1
8.8
—
—
—
0
0
237
1884
1.56
4.99
7.9
6.3
11.7
11.1
umol/l
0.38
225
1782
397
3603
2.09
4.94
20.6
13.7
22.8
22.9
mg/l
0.02
339
2820
24
89
2.79
4.93
1.8
1.6
13.2
7.6
iu/l
—
8
29
134
939
1.62
4.83
3.4
2.9
—
—
—
0
0
183
1381
1.56
4.80
2.2
2.0
98.6
94.9
pmol/l
0.54
89
691
137
968
1.60
4.76
3.4
2.9
0.3
0.4
e6/l
0.25
101
726
43
213
2.13
4.76
3.8
3.2
7.4
7.4
ph
—
7
26
70
413
1.83
4.71
2.0
1.6
—
—
—
0
0
43
215
2.11
4.65
3.8
3.2
5.3
5.2
kpa
0.46
43
199
407
3752
2.20
4.47
17.8
12.8
—
—
—
0
0
145
1053
1.56
4.43
3.4
3.0
27.3
135.3
e6/l
1.03
109
811
139
1005
1.56
4.32
2.7
3.0
1179.4
1217.3
ng/l
0.05
118
856
50
272
1.95
4.31
1.6
1.5
—
—
—
0
0
178
1360
1.52
4.29
3.9
3.5
27.2
39.6
ng/l
1.13
130
949
104
706
1.62
4.20
2.8
2.5
6.2
4.7
e6/l
0.72
85
624
77
487
1.71
4.08
1.5
1.3
273.3
465.1
titre
1.64
18
102
152
1137
1.52
3.99
2.8
2.5
51.5
55.9
u/l
0.80
140
1054
12
33
3.71
3.95
1.4
1.2
—
—
—
0
0
193
1519
1.48
3.95
3.1
2.6
117.6
125.8
ug/l
0.26
180
1410
92
621
1.61
3.78
1.8
1.7
1117.3
1208.4
nmol/l
0.52
76
466
117
838
1.54
3.72
2.4
2.0
2.9
3.1
mg/l
0.25
104
719
32
156
2.13
3.72
4.3
3.4
—
—
—
0
0
60
366
1.74
3.61
3.4
4.3
3.0
19.4
ug/l
0.80
47
302
198
1586
1.45
3.61
11.0
9.2
0.0
0.0
e9/l
0.16
163
1309
14
46
3.11
3.56
1.6
1.7
90.0
89.7
%
0.09
14
46
36
187
2.01
3.55
6.3
12.2
—
—
—
0
0
178
1401
1.46
3.54
2.2
2.1
—
—
—
0
0
20
82
2.51
3.43
2.3
2.6
8.0
8.1
kpa
0.01
20
73
19
76
2.57
3.42
2.7
2.6
2.3
2.7
mmol/l
0.28
12
52
75
495
1.62
3.36
1.3
1.2
—
—
—
0
0
25
115
2.24
3.35
2.0
2.0
161.0
289.9
ug/l
1.06
25
109
17
66
2.64
3.25
1.5
1.2
—
—
—
0
0
112
821
1.49
3.15
1.6
1.5
20.6
20.9
nmol/l
0.08
98
709
96
686
1.51
3.04
2.7
2.6
593.9
558.0
mosm/kgh2o
0.74
77
583
53
329
1.70
3.01
2.8
2.5
0.2
0.2
g/l
0.93
48
308
5
5
10.09
2.98
1.2
1.0
—
—
—
0
0
19
82
2.38
2.95
2.1
3.2
25.9
36.0
umol/l
1.42
14
70
89
635
1.50
2.83
1.3
1.3
13.4
38.5
iu/ml
4.85
29
201
18
78
2.36
2.78
1.6
1.2
—
—
—
0
0
5
6
8.41
2.75
6.4
4.5
—
—
—
0
0
104
770
1.46
2.75
1.8
1.7
3.1
1.2
mg/l
0.53
80
605
124
949
1.43
2.75
3.1
2.5
3756.7
7765.0
umol/l
0.52
104
811
22
106
2.13
2.67
2.3
3.0
—
—
—
0
0
50
316
1.66
2.67
6.4
4.2
—
—
—
0
0
26
134
2.00
2.66
4.7
3.7
25.3
25.2
mmol/l
0.04
26
126
54
349
1.62
2.64
1.7
1.4
—
—
—
0
0
361
3320
1.50
2.64
21.1
14.5
39.0
40.2
%
1.31
267
2423
83
592
1.50
2.64
1.3
1.3
3.8
10.6
u/ml
1.47
20
242
366
3380
1.50
2.58
6.3
5.7
40.0
39.8
mmol/mol
0.20
342
3155
38
225
1.75
2.57
3.7
6.8
—
—
—
0
0
420
4019
2.10
2.53
28.9
20.0
251.5
249.2
e9/l
0.30
413
3911
107
809
1.43
2.52
3.6
3.4
—
—
—
0
0
420
4020
2.09
2.51
28.9
20.0
4.5
4.5
e12/l
0.52
412
3901
50
322
1.62
2.49
4.0
3.6
5.8
5.8
kpa
0.04
50
314
420
4021
2.08
2.49
28.9
20.1
6.9
6.6
e9/l
2.30
413
3903
15
63
2.43
2.49
2.5
2.3
—
—
—
0
0
7
16
4.43
2.48
1.1
1.1
—
—
—
0
0
42
261
1.67
2.40
1.5
1.4
—
—
—
0
0
377
3516
1.52
2.39
5.1
4.5
5.9
6.0
mmol/l
0.34
345
3225
33
193
1.77
2.34
1.3
1.3
—
—
—
0
0
407
3868
1.74
2.33
14.3
10.3
27.9
26.5
u/l
0.52
395
3732
49
320
1.60
2.32
4.1
3.6
1.5
1.9
mmol/l
0.38
43
256
129
1021
1.37
2.31
3.4
2.9
—
—
—
0
0
96
724
1.42
2.28
1.8
1.7
433.1
442.0
pmol/l
0.11
80
608
38
235
1.68
2.22
1.2
1.2
182.6
148.3
iu/ml
0.13
16
102
18
87
2.11
2.20
2.9
2.5
25.2
25.2
mmol/l
0.00
18
75
9
30
3.04
2.16
1.8
1.1
—
—
—
0
0
23
124
1.90
2.11
2.2
1.8
24.7
21.4
s
0.85
23
116
62
438
1.48
2.08
1.7
1.4
—
—
—
0
0
5
10
5.04
2.07
1.2
1.2
—
—
—
0
0
7
20
3.54
2.06
12.3
7.6
—
—
—
0
0
128
1030
1.34
2.04
4.3
3.8
—
—
—
0
0
8
26
3.11
2.02
1.1
1.1
—
—
—
0
0
8
26
3.11
2.02
1.1
1.2
—
—
—
0
0
5
11
4.58
1.94
1.2
1.0
—
—
—
0
0
11
45
2.48
1.94
4.0
2.8
—
—
—
0
0
10
39
2.60
1.93
1.7
1.4
—
—
—
0
0
10
39
2.60
1.93
1.2
1.3
—
—
—
0
0
71
523
1.43
1.92
2.6
2.0
—
—
—
0
0
7
22
3.22
1.88
1.3
1.3
—
—
—
0
0
42
279
1.56
1.88
3.5
2.6
4.6
4.5
kpa
0.11
42
269
281
2537
1.30
1.87
4.4
3.7
—
—
—
0
0
9
34
2.68
1.87
2.6
2.6
—
—
—
0
0
11
46
2.43
1.86
2.7
3.1
—
—
—
0
0
14
66
2.16
1.84
2.9
2.6
—
—
—
0
0
8
29
2.79
1.80
1.4
1.3
—
—
—
0
0
205
1785
1.28
1.79
3.8
3.5
0.0
0.0
estimate
0.00
33
322
18
95
1.93
1.78
1.1
1.1
—
—
—
0
0
101
800
1.34
1.77
1.3
1.2
6.8
1.9
u/ml
0.39
22
235
10
41
2.47
1.76
1.1
1.0
0.1
4.5
u/ml
—
5
14
57
410
1.45
1.76
2.0
1.7
—
—
—
0
0
6
18
3.36
1.75
1.2
1.2
—
—
—
0
0
57
411
1.44
1.74
4.8
2.9
9.8
7.8
umol/l
0.32
49
363
125
1025
1.31
1.72
3.1
3.3
559.2
303.2
mg/l
0.20
80
654
5
13
3.88
1.72
3.4
4.0
—
—
—
0
0
82
634
1.36
1.68
3.3
2.8
2.4
2.4
mmol/l
0.14
76
559
7
25
2.83
1.65
1.6
2.5
—
—
—
0
0
44
305
1.49
1.64
1.5
1.4
—
—
—
0
0
384
3659
1.40
1.53
5.5
4.9
2.7
2.8
mmol/l
1.31
350
3370
56
413
1.41
1.53
1.2
1.3
—
—
—
0
0
378
3593
1.38
1.53
5.0
4.4
4.6
4.7
mmol/l
1.11
345
3334
5
15
3.36
1.52
1.0
1.1
161.7
137.9
nmol/l
—
5
15
5
15
3.36
1.52
3.4
3.6
—
—
—
0
0
200
1761
1.25
1.52
5.2
4.8
0.0
0.0
estimate
0.00
35
334
78
611
1.34
1.48
2.2
1.9
—
—
—
0
0
66
505
1.36
1.45
1.9
1.7
—
—
—
0
0
199
1759
1.24
1.44
3.7
3.5
0.0
0.0
estimate
0.00
35
332
41
289
1.46
1.43
1.8
2.3
6.0
8.3
ug/l
0.39
31
263
129
1086
1.27
1.43
3.9
4.0
10.1
7.1
mg/mmol
0.28
79
674
10
46
2.20
1.41
1.2
1.1
—
—
—
0
0
38
265
1.48
1.40
1.1
1.2
—
—
—
0
0
7
29
2.44
1.39
1.1
1.2
—
—
—
0
0
57
429
1.38
1.39
2.4
2.3
83.5
128.8
ug/g
1.41
41
341
130
1100
1.26
1.38
3.0
3.1
7.8
7.7
mmol/l
0.06
100
910
8
34
2.38
1.29
1.3
1.3
—
—
—
0
0
27
178
1.55
1.29
3.2
2.4
1.1
1.3
%
0.59
27
178
57
435
1.36
1.29
1.4
1.3
—
—
—
0
0
5
18
2.80
1.29
1.0
1.4
—
—
—
0
0
137
1176
1.24
1.27
4.2
4.5
1.8
2.4
ug/l
1.00
119
1061
12
215
0.55
1.27
1.7
1.5
—
—
—
0
0
8
36
2.24
1.25
1.8
1.3
—
—
—
0
0
363
3457
1.29
1.22
4.5
4.0
1.3
1.3
mmol/l
0.24
331
3177
8
37
2.18
1.22
2.5
2.6
—
—
—
0
0
17
101
1.71
1.21
1.2
1.2
—
—
—
0
0
19
118
1.64
1.17
1.6
1.6
—
—
—
0
0
21
134
1.60
1.16
1.3
1.2
—
—
—
0
0
8
39
2.07
1.16
1.6
1.3
—
—
—
0
0
18
111
1.65
1.14
1.5
1.3
—
—
—
0
0
8
40
2.02
1.12
3.1
3.2
4.5
3.3
nmol/l
—
8
40
7
32
2.21
1.08
1.7
1.0
—
—
—
0
0
7
33
2.14
1.06
1.7
1.7
—
—
—
0
0
5
22
2.29
1.03
1.0
1.7
—
—
—
0
0
7
34
2.08
1.03
1.3
1.2
413.6
381.0
nmol/l
—
7
28
372
3573
1.27
1.03
5.1
4.4
1.5
1.5
mmol/l
0.17
338
3299
17
107
1.61
1.01
5.5
11.0
1.1
1.2
mmol/l
0.18
17
96
11
61
1.82
0.99
3.3
3.7
60.5
59.2
%
0.18
11
61
16
100
1.62
0.98
1.3
1.2
8.9
9.5
u/l
—
9
79
16
100
1.62
0.98
1.6
2.2
11.1
11.4
mg/l
0.04
16
94
13
77
1.71
0.96
1.7
1.8
—
—
—
0
0
13
77
1.71
0.96
6.2
13.1
104.6
105.3
mmol/l
0.14
13
70
13
77
1.71
0.96
6.1
13.1
13.2
10.8
mmol/l
0.42
13
70
0
32
0.00
0.95
0.0
1.2
—
—
—
0
0
32
236
1.38
0.93
1.9
1.6
1.2
1.4
g/l
0.47
27
216
8
42
1.92
0.89
1.6
1.3
0.6
0.5
nmol/l
—
8
37
8
43
1.88
0.87
1.5
3.7
—
—
—
0
0
19
128
1.51
0.87
1.9
1.8
—
—
—
0
0
6
30
2.01
0.87
2.0
2.9
—
—
—
0
0
6
30
2.01
0.87
2.3
1.2
—
—
—
0
0
8
44
1.83
0.86
1.8
1.3
—
—
—
0
0
48
385
1.28
0.81
1.6
1.7
—
—
—
0
0
16
106
1.53
0.80
1.0
1.4
456.2
280.5
ug/g
—
5
60
6
33
1.83
0.79
1.3
1.2
—
—
—
0
0
23
166
1.41
0.77
1.3
1.8
—
—
—
0
0
10
59
1.71
0.76
3.0
3.3
4.0
4.7
e9/l
—
10
59
11
67
1.66
0.75
3.0
1.5
—
—
—
0
0
7
38
1.86
0.74
1.1
1.2
—
—
—
0
0
38
300
1.29
0.74
3.9
3.6
—
—
—
0
0
15
100
1.52
0.73
1.7
2.4
3312.7
2727.0
u/l
—
5
34
9
56
1.62
0.72
1.2
1.4
—
—
—
0
0
9
58
1.56
0.70
4.9
3.2
0.7
0.7
nmol/l
—
9
48
32
249
1.31
0.69
1.1
1.2
—
—
—
0
0
9
59
1.54
0.68
1.3
1.1
—
—
—
0
0
5
28
1.79
0.66
1.0
1.1
—
—
—
0
0
35
280
1.27
0.63
3.0
2.6
70.2
71.3
e9/l
0.06
23
212
18
130
1.40
0.62
3.2
4.4
—
—
—
0
0
5
30
1.67
0.61
4.2
1.6
8.0
12.0
%
—
5
30
5
30
1.67
0.61
1.0
1.3
0.4
1.4
promille
—
5
23
0
20
0.00
0.60
0.0
1.4
—
—
—
0
0
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
0
21
0.00
0.60
0.0
16.2
—
1564.8
—
0
21
19
140
1.37
0.59
5.2
8.7
0.9
0.9
%
0.10
19
132
17
123
1.40
0.58
1.3
1.4
—
—
—
0
0
82
723
1.17
0.58
1.7
1.4
2.2
2.5
g/l
0.76
46
438
19
141
1.36
0.57
5.2
8.7
1.7
1.6
%
0.13
19
132
17
124
1.39
0.56
1.3
1.4
—
—
—
0
0
17
124
1.39
0.56
1.3
1.4
—
—
—
0
0
8
55
1.46
0.56
1.1
1.1
—
—
—
0
0
15
107
1.42
0.56
1.1
1.5
155.2
276.0
miu/ml
—
5
49
10
65
1.55
0.56
1.1
1.1
—
—
—
0
0
10
65
1.55
0.56
1.1
1.1
—
—
—
0
0
28
222
1.28
0.55
2.9
2.7
—
—
—
0
0
16
116
1.39
0.55
1.3
1.4
—
—
—
0
0
12
82
1.48
0.55
4.6
3.0
—
—
—
0
0
17
125
1.37
0.54
1.3
1.4
—
—
—
0
0
15
203
0.73
0.53
6.5
2.7
26.4
45.6
u/ml
0.57
15
194
122
1327
0.89
0.50
3.0
2.8
—
—
—
0
0
10
69
1.46
0.44
1.2
1.1
—
—
—
0
0
9
129
0.69
0.44
12.3
10.1
—
—
—
0
0
13
96
1.37
0.42
1.4
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
38.6
—
0
9
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
16
123
1.31
0.41
2.0
3.4
0.4
0.2
g/l
—
6
50
18
141
1.29
0.41
1.3
1.3
15.6
27.2
iu/l
1.33
13
120
34
288
1.20
0.40
4.1
3.2
—
—
—
0
0
8
60
1.34
0.40
1.1
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.5
—
—
—
0
0
0
19
0.00
0.39
0.0
1.0
—
—
—
0
0
0
19
0.00
0.39
0.0
1.8
—
—
—
0
0
90
824
1.12
0.38
4.1
4.7
—
—
—
0
0
9
68
1.33
0.38
4.2
3.8
39.4
26.9
u/ml
—
9
68
14
107
1.32
0.37
1.1
1.1
—
—
—
0
0
27
320
0.83
0.36
1.7
1.5
—
—
—
0
0
17
135
1.27
0.35
1.1
1.0
—
—
—
0
0
6
46
1.31
0.33
1.0
1.3
—
—
—
0
0
30
258
1.17
0.32
5.4
3.6
72.1
79.8
ng/l
0.23
30
230
7
52
1.35
0.31
1.4
1.5
—
—
—
0
0
7
52
1.35
0.31
1.4
1.5
—
—
—
0
0
7
52
1.35
0.31
1.4
1.5
—
—
—
0
0
7
52
1.35
0.31
1.4
1.5
—
—
—
0
0
19
229
0.82
0.31
1.5
2.6
—
—
—
0
0
7
96
0.72
0.31
1.7
1.3
—
—
—
0
0
33
289
1.15
0.29
2.9
4.4
0.1
0.2
%
—
10
83
75
693
1.10
0.28
2.6
2.8
0.7
0.8
ug/l
0.26
44
451
13
103
1.27
0.28
1.6
2.4
65.7
66.6
ug/min
—
8
56
8
62
1.30
0.28
1.0
1.8
—
—
—
0
0
20
168
1.20
0.27
1.1
1.1
—
—
—
0
0
9
72
1.26
0.26
2.2
2.1
—
—
—
0
0
21
179
1.18
0.25
2.2
2.7
0.4
0.2
e6/l
0.72
21
171
34
302
1.14
0.25
1.6
1.7
—
—
—
0
0
31
275
1.14
0.24
3.1
4.4
0.0
0.1
%
—
8
70
10
79
1.27
0.22
1.8
1.2
—
—
—
0
0
5
41
1.22
0.22
1.4
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
5
43
1.16
0.21
1.8
2.1
—
—
—
0
0
20
174
1.16
0.20
1.0
1.1
—
104.2
—
0
5
6
52
1.16
0.19
9.7
4.6
402.0
340.6
umol/l
—
6
47
6
53
1.13
0.18
1.3
2.6
107.7
106.2
mmol/l
—
6
53
6
53
1.13
0.18
1.3
2.6
4.0
4.0
mmol/l
—
6
53
6
53
1.13
0.18
1.3
2.6
—
—
—
0
0
103
985
1.06
0.18
1.8
1.7
1.3
1.4
mmol/l
0.57
85
844
20
177
1.14
0.16
3.4
3.7
—
—
—
0
0
6
80
0.75
0.15
1.3
1.6
—
—
—
0
0
6
80
0.75
0.15
1.3
4.6
—
—
—
0
0
34
313
1.09
0.15
3.0
4.2
0.7
0.9
%
—
10
96
9
107
0.84
0.13
1.9
4.1
33.3
98.7
mg/l
—
9
84
9
107
0.84
0.13
1.9
4.1
26.7
31.8
mg/l
—
9
85
82
787
1.05
0.13
4.1
3.7
1.0
1.0
kg/l
0.01
14
111
19
171
1.12
0.12
3.2
2.4
—
—
—
0
0
13
147
0.88
0.11
1.0
1.1
—
—
—
0
0
103
998
1.04
0.11
1.4
1.4
—
—
—
0
0
14
124
1.13
0.11
1.6
1.4
0.2
0.2
g/l
0.03
14
118
38
358
1.07
0.11
1.5
1.4
—
—
—
0
0
5
44
1.14
0.10
1.0
1.2
—
—
—
0
0
14
126
1.11
0.09
3.4
2.8
—
—
—
0
0
6
57
1.05
0.08
1.3
1.6
—
—
—
0
0
5
63
0.79
0.08
1.0
1.4
—
—
—
0
0
5
63
0.79
0.08
1.0
1.4
—
—
—
0
0
5
65
0.77
0.08
1.0
1.5
—
—
—
0
0
6
71
0.84
0.07
1.0
1.8
—
—
—
0
0
9
103
0.87
0.06
3.9
4.5
—
—
—
0
0
92
937
0.98
0.05
4.5
3.7
0.0
0.0
estimate
0.00
34
327
29
279
1.04
0.04
3.2
4.3
0.1
0.4
%
—
7
62
26
250
1.04
0.03
2.8
2.6
4.1
4.1
e9/l
0.02
21
199
101
998
1.02
0.03
3.2
3.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
1.2
—
0
9
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.1
—
278.4
—
0
8
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
53
0.94
0.00
1.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
0.00
0.0
5.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
3.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
40.8
—
0
5
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint G6_HORNER and mortality.

Females

Parameter HR [95% CI] p-value
G6_HORNER 1.65 [1.36, 2.0] < 0.001
Birth year 0.998 [0.99, 1.01] 0.712

During the follow-up period (1.1.1998 — 31.12.2019), 199 out of 1204 females with G6_HORNER died.

Males

Parameter HR [95% CI] p-value
G6_HORNER 1.362 [1.12, 1.65] 0.002
Birth year 0.988 [0.98, 1.0] 0.016

During the follow-up period (1.1.1998 — 31.12.2019), 172 out of 1188 males with G6_HORNER died.

Mortality risk

Mortality risk for people of age

years, who have G6_HORNER.

N-year risk Females Males
1 0.154% 0.27%
5 0.995% 1.74%
10 2.61% 4.415%
15 5.056% 8.223%
20 9.002% 13.224%

Relationships between endpoints

↥

Index endpoint: G6_HORNER – Horner syndrome

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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