No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
453 |
4. Check minimum number of eventsNone |
453 |
5. Include endpointsNone |
453 |
6. Filter based on genotype QC (FinnGen only) |
438 |
Control definitions (FinnGen only)
- Control exclude
- G6_AUTONOM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G90
- Name in latin
- Syndroma Horner
Similar endpoints
↥List of similar endpoints to
Horner syndrome
based on the number of shared cases.
Similar with more cases:
- Autonomic disorders
- Other neurological diseases
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2743 | 1372 | 1366 |
| Only index persons | 2515 | 1258 | 1257 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 52.54 | 54.09 | 50.94 |
| Only index persons | 52.78 | 54.46 | 51.10 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 438 | 241 | 197 |
| Unadjusted period prevalence (%) | 0.09 | 0.09 | 0.09 |
| Median age at first event (years) | 55.58 | 55.63 | 55.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 453
- Matched controls
- 4530
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G90.2
ICD-10 Finland
Horner syndrome
+∞
307.7
445
*
H02.4
ICD-10 Finland
Ptosis of eyelid
15.0
83.3
79
63
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
11.2
57.7
65
67
H57.0
ICD-10 Finland
Anomalies of pupillary function
56.1
35.1
41
8
AA1AD
NOMESCO Finland
CT of head and brain
3.4
34.1
187
778
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
9.9
30.4
36
39
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.6
30.2
80
200
I67.0
ICD-10 Finland
Dissection of cerebral arteries, nonruptured
148.9
26.9
28
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.7
23.4
259
1503
XCK00
NOMESCO Finland
Perimetry
4.7
22.0
54
126
G44.0
ICD-10 Finland
Cluster headache syndrome
22.8
21.1
30
14
PA6CG
NOMESCO Finland
Extensive MRI examination of neck vasculature with high intensity magnet
73.1
18.9
21
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
6.5
18.4
31
51
XCK10
NOMESCO Finland
Photography of fundus of eye
3.2
15.6
68
236
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.3
15.6
66
225
B01AA03
ATC
warfarin; systemic
2.6
15.5
104
458
N03AX16
ATC
[U] pregabalin
2.4
14.9
134
675
PA6AD
NOMESCO Finland
CT of neck arteries
5.0
13.7
30
63
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
10.1
13.4
26
27
PA6BG
NOMESCO Finland
MRI examination of neck vasculature with high intensity magnet
41.4
13.2
16
*
CBJ41
NOMESCO Finland
Shortening of superior tarsal muscle (Müller's muscle)
48.0
11.9
14
*
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
5.3
11.4
23
45
CBJ40
NOMESCO Finland
Resection of levator muscle of eyelid
13.2
11.2
19
15
XLA10, ,
NOMESCO Finland
4.6
11.1
27
62
WX002
NOMESCO Finland
Sedation and analgesia
2.3
11.0
105
535
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
3.1
10.5
46
160
N02AX02
ATC
tramadol; systemic, rectal
1.9
10.3
213
1436
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.2
9.9
99
513
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.5
9.8
35
107
TAB00
NOMESCO Finland
Lumbar puncture
3.3
9.6
37
119
35800
ICD-8 Finland
Disease of peripheral autonomic nervous system, Syndroma Horner
+∞
9.4
9
*
R51.80
ICD-10 Finland
Headache
2.2
9.4
89
451
WX110
NOMESCO Finland
Infiltration anesthesia
2.0
9.4
329
2599
I63.2
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
14.1
9.2
15
11
R42
ICD-10 Finland
Dizziness and giddiness
2.0
8.8
112
633
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.8
8.8
44
165
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.5
8.7
58
252
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
3.2
8.1
32
104
C08DA01
ATC
verapamil; systemic
3.3
8.1
31
99
PA7BD
NOMESCO Finland
CT angiography of neck and brain
7.5
8.0
18
25
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
15.4
7.8
12
8
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.0
7.6
35
125
H02AB06
ATC
prednisolone; systemic
1.7
7.6
216
1560
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
3.8
7.6
23
63
N06AX21
ATC
duloxetine; oral
2.3
7.4
62
298
Q13.2
ICD-10 Finland
Other congenital malformations of iris
30.5
7.2
9
*
CBJ30
NOMESCO Finland
Plastic repair of levator aponeurosis of eyelid
20.4
7.2
10
5
C10AA05
ATC
atorvastatin; oral
1.7
7.1
189
1334
H53.1
ICD-10 Finland
Subjective visual disturbances
2.7
7.1
39
154
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.8
7.0
35
131
A02BC05
ATC
esomeprazole; systemic
1.7
6.8
190
1353
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
12.5
6.6
11
9
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
2.1
6.6
65
333
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
6.5
120
758
N06AB10
ATC
escitalopram; oral
1.9
6.4
94
554
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.2
6.3
57
282
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.1
6.3
64
332
I72.0
ICD-10 Finland
Aneurysm and dissection of carotid artery
27.1
6.2
8
*
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
5.9
6.2
16
28
A02BC02
ATC
pantoprazole; systemic
1.7
6.2
304
2483
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.2
6.2
51
243
H57.1
ICD-10 Finland
Ocular pain
3.2
6.1
24
78
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
8.8
6.1
12
14
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
247
1634
2.13
13.78
6.8
6.2
1.21
1.22
mmol/l
0.60
228
1496
244
1671
2.00
11.69
12.2
13.3
1.28
1.24
inr
0.21
65
510
256
1789
1.99
11.50
8.5
6.9
1.22
1.22
mmol/l
0.05
214
1531
179
1108
2.02
11.36
2.4
2.0
184.14
266.97
u/l
0.61
169
1043
292
2168
1.98
10.65
5.7
4.9
6.53
6.71
mmol/l
0.77
280
2022
252
1791
1.92
10.36
7.3
5.8
26.10
28.06
%
2.21
239
1690
246
1777
1.84
9.19
7.2
5.6
58.30
56.93
%
1.04
234
1679
340
2761
1.93
8.32
5.5
4.1
12.41
11.79
mm/h
0.28
325
2546
280
2153
1.79
8.05
10.0
9.1
4.43
4.04
e9/l
1.72
248
1897
213
1550
1.71
7.13
6.1
4.8
35.25
35.75
g/l
0.63
196
1445
426
3842
2.83
6.87
21.8
15.9
3.96
3.97
mmol/l
0.78
416
3734
425
3831
2.77
6.81
21.7
15.8
139.64
139.69
mmol/l
0.17
416
3726
392
3421
2.08
6.74
6.1
4.6
1.83
2.23
mu/l
0.59
366
3132
342
2870
1.78
6.46
10.2
7.6
81.61
78.14
u/l
0.49
323
2693
171
1216
1.65
5.98
3.5
3.3
2.34
2.35
mmol/l
0.84
152
1082
133
887
1.71
5.92
2.4
2.3
—
—
—
0
0
22
70
3.25
5.82
2.0
2.4
17.23
16.22
%
—
10
32
110
708
1.73
5.53
4.3
3.8
94.62
312.02
ng/l
1.59
86
541
331
2814
1.65
5.28
5.1
3.8
14.94
14.76
pmol/l
0.61
308
2552
71
407
1.88
5.22
6.3
9.2
0.82
1.16
mmol/l
0.25
58
338
411
3726
2.11
5.20
20.3
13.8
22.42
22.91
mg/l
0.10
350
2921
142
995
1.62
5.12
3.4
3.0
0.36
0.42
e6/l
0.14
107
744
92
581
1.73
4.91
2.0
1.9
—
—
—
0
0
80
491
1.76
4.71
2.6
2.2
21.10
23.72
%
0.91
72
420
243
1956
1.52
4.63
7.9
6.3
11.65
11.09
umol/l
0.33
231
1851
150
1087
1.57
4.62
3.4
3.1
26.54
132.28
e6/l
1.04
113
832
193
1480
1.53
4.61
2.5
2.3
78.28
77.00
nmol/l
0.27
176
1325
42
209
2.11
4.59
3.8
3.6
1.64
2.00
mmol/l
0.36
36
160
218
1723
1.51
4.47
2.8
2.6
—
—
—
0
0
187
1432
1.52
4.45
2.2
2.0
98.07
94.86
pmol/l
0.45
91
713
24
95
2.61
4.37
1.8
1.6
13.24
6.97
iu/l
—
8
32
8
9
9.02
4.29
1.0
1.0
—
—
—
0
0
43
223
2.03
4.23
3.8
3.5
5.30
5.17
kpa
0.47
43
215
168
1277
1.50
4.06
3.5
3.0
—
—
—
0
0
183
1416
1.49
4.05
3.9
3.5
27.13
38.38
ng/l
1.01
131
994
141
1038
1.52
3.95
2.6
3.0
1169.68
1218.39
ng/l
0.06
119
885
389
3535
1.71
3.89
18.3
12.6
83.13
81.85
ml/min/173m2
0.58
339
2908
67
413
1.73
3.87
1.9
1.9
—
—
—
0
0
198
1570
1.46
3.82
3.1
2.6
120.27
129.96
ug/l
0.31
184
1456
294
2517
1.48
3.79
4.2
3.2
44.81
51.59
u/l
1.35
272
2363
156
1184
1.48
3.74
2.9
2.6
51.47
61.51
u/l
1.35
144
1098
67
418
1.71
3.71
1.9
1.9
—
—
—
0
0
94
644
1.58
3.60
1.8
1.7
1124.61
1203.36
nmol/l
0.44
78
485
61
377
1.71
3.50
3.4
4.3
2.97
18.80
ug/l
0.80
48
313
25
113
2.28
3.48
2.6
2.9
—
—
—
0
0
14
47
3.04
3.44
1.6
1.7
90.03
89.79
%
0.07
14
47
13
37
3.59
3.43
1.4
1.2
—
—
—
0
0
89
609
1.57
3.42
2.8
2.6
0.90
0.87
e6/l
0.04
53
338
11
27
4.15
3.41
1.1
1.0
—
—
—
0
0
11
27
4.15
3.41
1.1
1.0
1.15
1.15
u/l
—
6
17
119
869
1.50
3.41
2.4
2.0
2.89
3.06
mg/l
0.29
106
747
61
380
1.70
3.40
4.7
4.1
280.00
247.31
u/l
0.42
61
359
13
42
3.16
3.39
1.1
1.1
—
—
—
0
0
13
42
3.16
3.39
1.4
1.4
—
—
—
0
0
161
1249
1.45
3.39
4.0
3.4
42.29
32.39
u/l
0.96
156
1185
84
570
1.58
3.35
2.9
2.8
3.55
2.19
e6/l
0.34
47
301
94
655
1.55
3.34
1.3
1.3
13.24
38.72
iu/ml
5.20
30
210
38
206
1.92
3.33
1.7
1.7
—
—
—
0
0
110
798
1.50
3.24
1.8
1.7
3.00
1.19
mg/l
0.52
83
625
88
612
1.54
3.15
1.3
1.3
3.58
10.43
u/ml
1.59
22
247
129
982
1.44
2.95
3.0
2.5
3660.92
7671.58
umol/l
0.54
107
848
379
3486
1.53
2.87
6.2
5.6
39.96
39.76
mmol/mol
0.15
355
3253
114
856
1.44
2.79
1.6
1.5
20.77
20.94
nmol/l
0.04
99
738
41
243
1.76
2.74
1.6
1.6
—
—
—
0
0
435
4158
2.16
2.73
28.7
20.2
251.17
249.41
e9/l
0.22
428
4049
20
92
2.23
2.71
2.1
1.4
—
—
—
0
0
435
4160
2.15
2.69
28.8
20.3
40.24
40.43
%
0.24
405
3903
9
24
3.80
2.68
1.1
1.2
—
—
—
0
0
435
4161
2.14
2.67
28.7
20.1
4.49
4.51
e12/l
0.56
427
4040
422
4002
1.80
2.59
14.2
10.3
27.70
26.98
u/l
0.24
410
3863
391
3640
1.54
2.59
5.0
4.5
5.88
5.96
mmol/l
0.55
357
3339
5
7
7.21
2.55
1.2
1.0
—
—
—
0
0
7
16
4.43
2.48
1.7
1.3
—
—
—
0
0
8
21
3.86
2.47
3.3
2.2
—
—
—
0
0
23
117
2.02
2.45
2.0
1.3
—
—
—
0
0
26
139
1.92
2.42
4.7
4.1
25.26
25.19
mmol/l
0.06
26
131
53
351
1.58
2.36
2.8
2.4
0.23
0.22
g/l
0.87
48
327
51
335
1.59
2.35
3.9
3.5
5.75
5.80
kpa
0.13
51
326
40
247
1.68
2.34
1.2
1.2
173.95
143.52
iu/ml
0.12
17
106
13
53
2.50
2.29
1.1
1.1
—
—
—
0
0
8
23
3.52
2.28
1.1
1.1
—
—
—
0
0
23
122
1.93
2.20
1.9
1.7
—
—
—
0
0
50
333
1.56
2.18
4.0
3.5
1.41
1.97
mmol/l
0.59
45
274
55
375
1.53
2.16
3.7
3.1
—
—
—
0
0
98
749
1.39
2.15
1.8
1.7
430.57
440.87
pmol/l
0.14
82
631
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
20
103
1.99
2.08
2.9
2.5
0.35
0.35
u/ml
0.03
11
58
12
51
2.39
1.96
1.1
1.1
—
—
—
0
0
6
16
3.79
1.94
1.2
1.8
—
—
—
0
0
212
1842
1.28
1.88
3.7
3.5
0.00
0.00
estimate
-0.00
35
331
62
447
1.45
1.88
5.3
4.4
31.79
32.13
%
0.09
42
298
85
649
1.38
1.87
3.4
2.8
2.45
2.45
mmol/l
0.13
79
573
6
17
3.56
1.84
2.2
2.7
593.50
715.35
u/ml
—
6
17
43
289
1.54
1.83
3.4
2.6
4.71
4.46
kpa
0.19
43
278
5
12
4.20
1.83
1.0
1.0
1596.60
1379.75
miu/ml
—
5
12
23
131
1.80
1.81
2.2
1.9
—
—
—
0
0
8
30
2.70
1.73
2.3
1.6
—
—
—
0
0
104
832
1.32
1.69
1.3
1.2
6.79
1.82
u/ml
0.40
22
247
10
40
2.53
1.67
1.0
1.4
—
—
—
0
0
391
3709
1.40
1.66
5.0
4.4
4.59
4.68
mmol/l
0.81
359
3446
15
76
2.01
1.66
1.9
1.5
—
—
—
0
0
7
25
2.83
1.65
1.6
1.3
438.00
353.33
u/l
—
7
25
397
3777
1.41
1.64
5.5
4.9
2.68
2.77
mmol/l
1.19
364
3485
16
84
1.94
1.61
1.4
1.3
—
—
—
0
0
207
1818
1.26
1.61
5.1
4.8
0.00
0.00
estimate
-0.00
37
344
12
57
2.14
1.56
2.1
1.5
—
—
—
0
0
28
177
1.62
1.55
3.1
2.4
0.60
0.65
%
0.70
28
177
13
64
2.06
1.55
2.1
1.6
—
—
—
0
0
14
71
2.00
1.55
1.8
1.4
—
—
—
0
0
377
3567
1.34
1.53
4.4
4.0
1.31
1.30
mmol/l
0.07
345
3280
143
1210
1.27
1.51
4.1
4.5
1.81
2.39
ug/l
1.02
125
1094
84
663
1.33
1.50
1.5
1.5
—
—
—
0
0
14
72
1.97
1.50
1.5
1.2
—
—
—
0
0
58
433
1.39
1.48
4.8
2.9
9.72
7.82
umol/l
0.30
50
381
20
117
1.74
1.47
1.7
1.5
—
—
—
0
0
5
16
3.15
1.44
1.2
1.8
—
—
—
0
0
5
16
3.15
1.44
1.2
1.8
—
—
—
0
0
6
22
2.75
1.44
1.2
1.1
—
—
—
0
0
205
1819
1.23
1.40
3.7
3.5
0.00
0.00
estimate
0.50
39
365
28
183
1.56
1.38
3.1
2.4
1.07
1.27
%
0.69
28
183
0
38
0.00
1.35
0.0
1.1
—
—
—
0
0
10
47
2.15
1.34
2.0
1.6
—
—
—
0
0
41
293
1.44
1.34
1.8
2.3
6.01
8.25
ug/l
0.38
31
267
11
54
2.06
1.34
2.3
1.6
—
—
—
0
0
12
62
1.96
1.29
3.8
3.7
60.83
59.16
%
0.25
12
62
256
2342
1.21
1.25
3.1
3.0
—
—
—
0
0
31
213
1.49
1.24
1.6
1.4
—
—
—
0
0
23
149
1.57
1.19
2.2
2.0
—
—
—
0
0
17
102
1.69
1.18
1.9
1.6
—
—
—
0
0
130
1119
1.23
1.16
3.7
3.8
10.17
6.88
mg/mmol
0.32
80
696
5
20
2.52
1.15
3.2
1.6
—
—
—
0
0
385
3689
1.29
1.15
5.0
4.4
1.47
1.46
mmol/l
0.03
352
3410
5
21
2.40
1.09
1.4
1.6
—
—
—
0
0
5
21
2.40
1.09
3.2
1.6
—
—
—
0
0
8
41
1.97
1.09
3.1
3.1
4.46
3.26
nmol/l
—
8
41
17
105
1.64
1.07
1.8
2.1
10.58
11.41
mg/l
0.13
17
98
131
1137
1.21
1.07
3.0
3.1
7.75
7.74
mmol/l
0.01
101
953
11
60
1.85
1.03
3.5
3.3
4.13
4.73
e9/l
0.52
11
60
11
60
1.85
1.03
2.0
1.5
—
—
—
0
0
7
133
0.52
1.00
1.4
1.5
—
—
—
0
0
23
329
0.68
0.99
1.9
1.8
—
—
—
0
0
5
23
2.19
0.98
3.2
1.6
—
—
—
0
0
16
100
1.62
0.98
1.9
1.7
—
—
—
0
0
13
77
1.71
0.96
1.3
1.6
—
—
—
0
0
61
493
1.27
0.95
2.2
1.7
1.76
1.47
%
1.17
54
433
12
70
1.73
0.93
1.9
1.7
—
—
—
0
0
8
42
1.92
0.89
1.6
1.3
0.63
0.48
nmol/l
—
8
37
8
42
1.92
0.89
1.1
1.2
—
—
—
0
0
16
103
1.57
0.88
1.0
1.1
—
—
—
0
0
27
197
1.39
0.84
1.1
1.0
—
—
—
0
0
16
105
1.54
0.82
1.7
2.5
2760.60
2655.44
u/l
—
6
35
6
32
1.89
0.82
3.2
2.2
—
—
—
0
0
26
190
1.39
0.81
2.4
2.1
—
—
—
0
0
17
114
1.51
0.80
1.3
1.7
—
—
—
0
0
6
33
1.83
0.79
1.3
1.5
160.32
165.36
pmol/l
—
6
33
9
53
1.71
0.76
2.4
2.9
—
996.71
—
0
7
11
67
1.66
0.75
2.8
1.4
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
24
2.10
0.74
1.2
1.2
—
—
—
0
0
24
177
1.38
0.72
2.8
3.4
24.72
25.08
mmol/l
0.18
24
172
16
109
1.49
0.72
1.1
1.5
155.20
276.02
miu/ml
—
5
49
16
109
1.49
0.72
1.0
1.4
456.20
279.76
ug/g
—
5
61
37
293
1.29
0.70
3.0
2.6
66.22
66.72
ml/min/173m2
0.03
18
124
7
41
1.72
0.70
1.1
1.2
—
—
—
0
0
5
27
1.86
0.68
1.8
1.2
—
—
—
0
0
15
102
1.49
0.68
1.1
1.3
—
—
—
0
0
110
981
1.16
0.66
3.5
4.0
25.13
21.61
%
1.25
50
457
12
78
1.55
0.66
2.6
1.9
—
—
—
0
0
14
96
1.47
0.62
1.3
1.3
—
—
—
0
0
8
50
1.61
0.61
1.1
1.2
—
—
—
0
0
6
35
1.72
0.58
1.3
1.1
—
—
—
0
0
6
35
1.72
0.58
1.3
1.1
—
—
—
0
0
6
36
1.68
0.57
1.3
1.1
—
—
—
0
0
6
36
1.68
0.57
1.3
1.1
—
—
—
0
0
6
36
1.68
0.57
1.3
1.1
—
—
—
0
0
8
55
1.46
0.56
1.3
2.0
—
—
—
0
0
6
38
1.59
0.54
1.8
1.6
—
—
—
0
0
19
144
1.33
0.51
1.3
1.3
19.36
27.47
iu/l
0.66
14
122
52
448
1.18
0.49
7.6
6.5
—
—
—
0
0
16
211
0.75
0.48
6.2
2.9
25.63
45.87
u/ml
0.65
16
202
7
47
1.50
0.47
1.3
1.8
—
—
—
0
0
19
147
1.31
0.46
5.2
8.4
1.65
1.60
%
0.19
19
138
79
710
1.14
0.44
2.5
2.8
0.69
0.76
ug/l
0.32
46
457
0
15
0.00
0.41
0.0
1.1
—
8.86
—
0
15
5
34
1.48
0.40
1.0
1.4
0.36
1.31
promille
—
5
27
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
5
37
1.36
0.37
1.4
1.2
—
—
—
0
0
9
70
1.29
0.37
4.2
3.7
39.44
27.04
u/ml
—
9
70
5
79
0.63
0.36
1.0
1.5
—
—
—
0
0
6
43
1.40
0.35
1.3
1.9
—
—
—
0
0
17
136
1.26
0.34
1.9
2.1
—
—
—
0
0
13
100
1.31
0.34
1.7
1.4
—
—
—
0
0
11
142
0.77
0.31
2.1
2.0
—
—
—
0
0
7
54
1.30
0.30
1.0
1.4
—
—
—
0
0
14
111
1.27
0.30
1.1
1.1
—
—
—
0
0
7
55
1.28
0.30
1.4
1.5
—
—
—
0
0
7
55
1.28
0.30
1.4
1.5
—
—
—
0
0
14
112
1.26
0.28
1.1
1.1
—
—
—
0
0
8
65
1.23
0.27
1.6
1.4
—
—
—
0
0
8
65
1.23
0.27
1.6
1.4
—
—
—
0
0
108
1017
1.08
0.27
1.8
1.7
1.27
1.36
mmol/l
0.87
90
868
38
339
1.13
0.26
2.1
1.9
—
—
—
0
0
22
188
1.18
0.26
2.2
2.7
0.39
0.15
e6/l
0.71
22
179
9
73
1.24
0.25
1.6
1.6
—
—
—
0
0
9
73
1.24
0.25
1.6
1.6
—
—
—
0
0
12
96
1.26
0.24
1.2
1.3
—
—
—
0
0
13
106
1.23
0.23
1.5
2.2
65.69
65.61
ug/min
—
8
57
5
42
1.19
0.21
7.8
3.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
11
0.00
0.21
0.0
1.0
—
134.55
—
0
11
0
12
0.00
0.21
0.0
1.2
—
107.92
—
0
12
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
9
112
0.80
0.20
1.9
4.0
26.70
32.29
mg/l
—
9
90
9
112
0.80
0.20
1.9
4.0
33.32
95.79
mg/l
—
9
89
6
52
1.16
0.19
1.0
1.4
—
—
—
0
0
59
553
1.08
0.18
1.5
1.4
—
—
—
0
0
11
91
1.21
0.17
1.0
1.3
—
—
—
0
0
41
379
1.09
0.17
2.3
2.0
—
—
—
0
0
9
110
0.81
0.13
1.9
3.9
—
2.11
—
0
17
20
182
1.10
0.11
1.2
1.3
—
—
—
0
0
11
96
1.15
0.10
1.1
1.2
—
—
—
0
0
5
47
1.06
0.09
1.8
2.0
—
—
—
0
0
6
55
1.09
0.09
9.7
4.7
402.00
337.66
umol/l
—
6
50
6
57
1.05
0.08
1.3
2.6
107.67
105.93
mmol/l
—
6
57
5
61
0.82
0.08
1.2
1.0
—
—
—
0
0
5
60
0.83
0.08
1.0
1.1
—
—
—
0
0
7
68
1.03
0.08
1.0
1.1
—
—
—
0
0
6
75
0.80
0.07
1.0
1.4
—
—
—
0
0
6
75
0.80
0.07
1.0
1.4
—
—
—
0
0
6
75
0.80
0.07
1.0
1.4
—
—
—
0
0
10
111
0.90
0.06
1.6
1.4
—
—
—
0
0
83
811
1.03
0.06
4.1
3.6
1.02
1.02
kg/l
0.01
14
118
145
1431
1.02
0.05
4.0
3.6
—
—
—
0
0
14
131
1.07
0.03
1.6
1.4
0.23
0.23
g/l
0.05
14
124
95
961
0.99
0.02
4.5
3.7
0.00
0.00
estimate
-0.00
36
337
14
138
1.01
0.00
1.7
1.4
1.22
1.16
g/l
0.37
14
132
5
52
0.96
0.00
1.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
5
52
0.96
0.00
1.0
1.4
—
—
—
0
0
5
52
0.96
0.00
1.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
28.07
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
84
0.95
-0.00
1.6
1.7
243.63
237.22
pmol/l
—
8
78
5
51
0.98
-0.00
1.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
1.25
—
0
8
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
59
1.02
-0.00
1.3
1.2
4.55
7.29
mmol/l
—
6
47
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
53
0.94
-0.00
1.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_HORNER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HORNER | 1.65 [1.36, 2.0] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.712 |
During the follow-up period (1.1.1998 — 31.12.2019), 199 out of 1204 females with G6_HORNER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HORNER | 1.362 [1.12, 1.65] | 0.002 |
| Birth year | 0.988 [0.98, 1.0] | 0.016 |
During the follow-up period (1.1.1998 — 31.12.2019), 172 out of 1188 males with G6_HORNER died.
Mortality risk
Mortality risk for people of age
years, who have G6_HORNER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.154% | 0.27% |
| 5 | 0.995% | 1.74% |
| 10 | 2.61% | 4.415% |
| 15 | 5.056% | 8.223% |
| 20 | 9.002% | 13.224% |
Relationships between endpoints
↥Index endpoint: G6_HORNER – Horner syndrome
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data