autonomic nervous system disease: A disease involving the autonomic nervous system.
Other and unspecified disorders of autonomic nervous system
DOID EFO Endpoint Browser PheWeb
G6_AUTOTHUNS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
137 |
4. Check minimum number of eventsNone |
137 |
5. Include endpointsNone |
137 |
6. Filter based on genotype QC (FinnGen only) |
137 |
Control definitions (FinnGen only)
- Control exclude
- G6_AUTONOM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified disorders of autonomic nervous system
based on the number of shared cases.
Similar with more cases:
- Autonomic disorders
- Other neurological diseases
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1130 | 550 | 569 |
| Only index persons | 923 | 477 | 446 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 50.73 | 48.91 | 52.18 |
| Only index persons | 48.28 | 47.06 | 49.57 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 137 | 80 | 57 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 48.53 | 46.05 | 52.01 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 110
- Matched controls
- 1102
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G90.9
ICD-10 Finland
Disorder of autonomic nervous system, unspecified
+∞
63.9
55
*
G90.8
ICD-10 Finland
Other disorders of autonomic nervous system
+∞
46.1
41
*
3378X
ICD-9 Finland
Disorders of the autonomic nervous system[NEUROPATHIA AUTONOMICA PERIPHERICA ALIA DEFINITA]
+∞
9.5
9
*
N03AX16
ATC
pregabalin; oral
4.2
9.4
41
136
R53
ICD-10 Finland
Malaise and fatigue
3.9
8.2
38
131
Z01.8
ICD-10 Finland
Other specified special examinations
3.7
7.2
35
124
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.1
6.4
25
73
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
19.4
6.4
9
5
N06AX21
ATC
duloxetine; oral
4.7
6.3
21
52
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
8.5
6.3
13
17
G90.0
ICD-10 Finland
Idiopathic peripheral autonomic neuropathy
+∞
6.3
6
*
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
4.3
6.1
22
60
U09.9
ICD-10 Finland
Post COVID-19 condition, unspecified
16.2
6.0
9
6
I20.90
ICD-10 Finland
Angina pectoris, unspecified
16.2
6.0
9
6
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
79
303
4.80
18.71
2.6
2.1
214.36
241.68
u/l
0.08
74
293
31
85
4.42
10.71
3.2
2.3
—
32.86
—
0
5
85
453
3.31
10.55
3.0
2.2
82.87
75.49
nmol/l
1.32
75
408
101
645
3.15
8.33
9.5
9.3
3.86
4.09
e9/l
0.63
91
567
76
426
2.76
7.86
6.6
4.8
36.21
36.41
g/l
0.13
70
405
85
508
2.77
7.70
9.9
7.6
1.22
1.22
mmol/l
0.03
74
436
69
382
2.62
7.13
2.4
1.8
98.43
96.55
pmol/l
0.16
36
197
50
242
2.68
6.71
2.5
1.8
0.57
0.97
mg/l
2.21
38
182
13
25
5.64
6.63
1.3
1.4
—
—
—
0
0
12
22
5.88
6.41
1.4
1.5
—
—
—
0
0
13
26
5.42
6.36
1.7
1.4
—
—
—
0
0
14
31
4.92
6.14
1.8
3.3
—
—
—
0
0
15
37
4.43
5.79
1.5
1.5
0.20
0.22
g/l
0.49
15
37
15
37
4.43
5.79
1.5
1.5
1.04
1.14
g/l
0.48
15
37
111
820
2.86
5.73
5.8
3.9
9.32
10.21
mm/h
0.40
105
756
74
459
2.33
5.57
8.1
6.8
1.21
1.22
mmol/l
0.28
68
427
81
535
2.26
5.10
4.4
2.6
144.77
100.28
ug/l
0.30
75
501
19
64
3.29
4.77
1.0
1.0
—
—
—
0
0
108
828
2.44
4.46
8.4
7.1
75.85
74.84
u/l
0.12
101
779
9
13
7.32
4.23
1.2
1.0
—
—
—
0
0
110
860
2.42
4.18
5.0
3.7
14.90
14.48
pmol/l
1.03
105
791
10
23
4.61
4.16
1.0
1.1
—
—
—
0
0
87
623
2.09
4.09
6.3
5.1
7.00
6.47
mmol/l
1.03
81
567
60
377
2.05
4.03
5.0
3.0
—
—
—
0
0
22
90
2.72
3.96
2.4
2.2
0.23
0.23
g/l
0.02
22
84
14
44
3.43
3.90
1.4
1.4
6.40
3.43
mg/l
—
9
30
22
91
2.69
3.87
1.5
1.2
87.00
104.38
iu/ml
—
9
38
37
197
2.20
3.78
1.6
1.3
4.49
8.68
u/ml
0.59
17
88
47
276
2.07
3.74
1.4
1.3
9.96
1.67
u/ml
0.67
18
71
46
268
2.08
3.74
2.9
2.7
321.34
4564.38
umol/l
1.05
38
236
31
155
2.29
3.67
2.1
1.6
1164.12
1181.86
nmol/l
0.03
23
118
33
172
2.21
3.54
1.9
2.6
2.44
2.44
mmol/l
0.03
26
153
8
14
5.99
3.39
1.3
1.0
—
—
—
0
0
23
105
2.43
3.32
2.3
2.0
40.33
28.32
u/l
0.35
18
87
8
15
5.59
3.24
1.3
1.0
—
—
—
0
0
12
39
3.28
3.17
3.0
1.5
—
—
—
0
0
12
39
3.28
3.17
2.0
2.5
164.00
190.10
%
0.35
12
39
35
195
2.07
3.15
1.7
1.8
450.96
457.74
pmol/l
0.05
27
167
49
309
1.91
3.11
5.2
2.8
0.17
0.42
e6/l
1.25
38
232
56
371
1.86
3.04
4.6
3.6
15.50
42.17
ng/l
1.65
29
236
5
5
10.31
3.00
1.0
1.0
—
—
—
0
0
11
36
3.24
2.88
1.3
3.4
3.58
3.62
g/l
—
6
26
11
36
3.24
2.88
1.3
3.4
—
—
—
0
0
76
560
1.80
2.87
4.7
5.8
12.47
13.13
umol/l
0.08
69
531
31
172
2.04
2.80
5.9
2.8
288.24
109.23
ng/l
0.28
21
114
5
6
8.59
2.77
1.4
1.8
—
—
—
0
0
73
537
1.77
2.73
5.0
3.3
0.00
0.00
estimate
0.00
19
109
120
1033
2.30
2.72
6.5
4.4
2.29
1.84
mu/l
0.35
113
955
10
33
3.19
2.58
1.7
1.1
—
—
—
0
0
5
7
7.36
2.57
2.0
1.1
—
—
—
0
0
5
7
7.36
2.57
2.0
1.1
—
—
—
0
0
29
163
1.99
2.52
3.7
2.6
5.92
2.28
e6/l
0.60
18
81
8
21
3.98
2.50
1.3
1.0
—
—
—
0
0
120
1043
2.21
2.48
16.3
11.3
90.31
86.90
ml/min/173m2
0.86
106
841
41
261
1.81
2.46
3.7
3.1
626.45
1039.57
ng/l
1.21
35
214
6
12
5.17
2.43
1.2
3.7
2.43
1.33
nmol/l
—
6
12
7
17
4.28
2.39
1.6
1.4
0.37
0.42
nmol/l
—
7
17
0
61
0.00
2.30
0.0
1.5
—
—
—
0
0
127
1138
2.59
2.30
22.6
12.5
16.83
21.75
mg/l
1.26
100
866
43
284
1.75
2.26
5.2
4.0
33.17
10.62
mg/mmol
0.49
23
173
72
548
1.66
2.23
5.2
3.4
0.00
0.00
estimate
0.00
20
99
5
9
5.72
2.23
1.6
2.4
—
—
—
0
0
5
9
5.72
2.23
1.4
1.2
—
—
—
0
0
58
420
1.66
2.16
5.1
3.3
—
—
—
0
0
71
543
1.64
2.13
8.0
4.6
0.00
0.00
estimate
0.00
20
107
34
213
1.79
2.12
1.6
1.2
87.07
29.50
iu/ml
—
10
65
0
56
0.00
2.12
0.0
1.4
—
—
—
0
0
0
56
0.00
2.12
0.0
1.4
—
—
—
0
0
0
56
0.00
2.12
0.0
1.4
—
—
—
0
0
40
264
1.73
2.09
3.0
1.8
2.92
2.93
mg/l
0.01
34
229
5
10
5.14
2.09
1.0
1.0
—
—
—
0
0
5
10
5.14
2.09
1.4
1.2
—
—
—
0
0
50
354
1.65
2.01
3.9
3.5
2.35
2.36
mmol/l
0.04
40
311
29
176
1.82
2.00
3.8
2.5
0.85
1.01
e6/l
0.18
18
93
5
11
4.67
1.96
1.0
2.1
—
—
—
0
0
14
65
2.29
1.96
4.4
4.8
25.69
24.39
mmol/l
1.04
14
65
19
102
2.00
1.87
8.9
11.8
1.79
1.49
mmol/l
0.19
13
81
6
17
3.64
1.86
2.5
1.5
—
—
—
0
0
5
14
3.66
1.63
1.0
2.0
—
—
—
0
0
5
15
3.42
1.53
1.0
2.1
—
—
—
0
0
11
53
2.17
1.43
2.2
1.8
—
—
—
0
0
25
163
1.65
1.35
2.0
1.9
—
—
—
0
0
5
18
2.84
1.29
1.0
1.9
—
—
—
0
0
18
112
1.70
1.16
2.3
1.7
—
—
—
0
0
15
89
1.77
1.13
2.5
3.2
—
—
—
0
0
18
113
1.68
1.12
2.3
1.7
—
—
—
0
0
11
59
1.94
1.11
1.5
1.4
—
—
—
0
0
11
59
1.94
1.11
2.5
1.9
—
—
—
0
0
5
21
2.43
1.10
2.2
3.2
130.60
128.23
g/l
—
5
13
5
21
2.43
1.10
1.6
1.0
—
—
—
0
0
5
21
2.43
1.10
1.6
1.0
—
—
—
0
0
12
67
1.87
1.08
1.8
1.5
—
—
—
0
0
108
979
1.49
1.08
5.8
4.9
39.81
38.68
mmol/mol
0.50
101
920
9
46
2.02
1.06
4.3
2.5
0.80
1.25
%
—
9
46
127
1197
1.84
1.03
13.1
9.5
25.74
25.10
u/l
0.18
121
1156
115
1063
1.51
0.97
4.2
4.1
5.95
5.81
mmol/l
0.39
107
983
91
808
1.38
0.96
3.4
2.9
58.87
40.33
u/l
0.55
82
768
18
119
1.59
0.94
6.9
6.8
104.33
104.49
mmol/l
0.04
18
113
32
241
1.43
0.92
1.9
2.2
—
—
—
0
0
37
290
1.38
0.85
4.3
3.5
0.00
0.00
estimate
0.00
20
103
5
24
2.12
0.75
1.0
1.4
—
—
—
0
0
7
38
1.89
0.75
1.4
1.1
—
—
—
0
0
5
25
2.04
0.73
1.8
2.4
—
—
—
0
0
7
43
1.66
0.68
1.4
1.4
—
—
—
0
0
25
191
1.38
0.67
3.2
2.3
—
—
—
0
0
5
28
1.81
0.67
1.2
1.2
—
—
—
0
0
8
124
0.62
0.58
1.6
1.7
—
—
—
0
0
6
37
1.65
0.56
1.2
1.1
—
—
—
0
0
13
91
1.47
0.55
1.8
1.9
—
—
—
0
0
26
211
1.29
0.48
3.3
2.4
—
—
—
0
0
29
240
1.26
0.46
1.4
1.5
—
—
—
0
0
15
114
1.35
0.43
2.2
2.0
—
—
—
0
0
6
46
1.32
0.33
1.0
1.2
—
—
—
0
0
108
1115
0.85
0.27
5.4
4.4
2.87
2.76
mmol/l
0.58
100
1034
103
1065
0.87
0.25
4.6
3.6
1.38
1.24
mmol/l
0.78
96
980
29
259
1.15
0.22
1.3
1.6
—
—
—
0
0
27
240
1.16
0.22
4.3
4.2
23.05
22.76
%
0.03
11
117
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
3.5
—
113.90
—
0
10
0
13
0.00
0.21
0.0
2.2
—
—
—
0
0
0
13
0.00
0.21
0.0
2.2
—
—
—
0
0
0
13
0.00
0.21
0.0
2.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
107
1098
0.88
0.19
5.0
4.0
1.42
1.47
mmol/l
0.60
98
1017
15
173
0.85
0.18
3.3
2.8
0.78
0.71
ug/l
—
8
120
8
72
1.12
0.16
3.1
1.3
—
—
—
0
0
87
841
1.09
0.16
4.8
3.5
—
—
—
0
0
14
121
1.17
0.15
9.1
6.9
—
—
—
0
0
48
505
0.92
0.13
4.1
4.2
—
—
—
0
0
108
1101
0.91
0.12
4.8
4.0
4.72
4.64
mmol/l
0.27
99
1028
129
1278
1.16
0.07
31.8
18.3
4.48
4.52
e12/l
0.41
123
1246
108
1079
1.00
0.00
27.0
13.4
39.63
40.56
%
0.55
80
840
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
7.2
—
—
—
0
0
0
6
0.00
0.00
0.0
4.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
4.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
216.20
—
0
5
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_AUTOTHUNS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_AUTOTHUNS | 2.676 [1.8, 3.98] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.258 |
During the follow-up period (1.1.1998 — 31.12.2019), 87 out of 362 females with G6_AUTOTHUNS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_AUTOTHUNS | 2.681 [2.0, 3.6] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 159 out of 402 males with G6_AUTOTHUNS died.
Mortality risk
Mortality risk for people of age
years, who have G6_AUTOTHUNS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.252% | 0.419% |
| 5 | 1.563% | 3.014% |
| 10 | 3.867% | 7.291% |
| 15 | 7.165% | 13.851% |
| 20 | 12.414% | 22.741% |
Relationships between endpoints
↥Index endpoint: G6_AUTOTHUNS – Other and unspecified disorders of autonomic nervous system
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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