Other specified/unspecified disorders of middle ear and mastoid

H8_MIDDMASTNAS

Otitis media: Inflammation of the anatomical structures of the middle ear, which is most often caused by an infectious process. Symptoms include erythema and edema of the tympanic membrane, pain, and possibly fever.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H74.8, H74.9 Hospital discharge: ICD-9 — 385[8-9] Cause of death: ICD-10 — H74.8, H74.9 Cause of death: ICD-9 — 385[8-9] 2 out of 7 registries used, show all original rules.	82
4. Check minimum number of events None	82
5. Include endpoints None	82
6. Filter based on genotype QC (FinnGen only)	82

Control definitions (FinnGen only)

Control exclude: H8_MIDDLEMASTOID

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2

NAME	H8_MIDDMASTNAS
CONTROL_EXCLUDE	H8_MIDDLEMASTOID
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H74[8-9]
HD_ICD_9	385[8-9]
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H74[8-9]
COD_ICD_9	385[8-9]
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other specified/unspecified disorders of middle ear and mastoid based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	788	397	384
Only index persons	681	343	338
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	49.36	49.06	49.54
Only index persons	49.00	48.89	49.11

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	82	54	28
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	52.59	49.96	57.68

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
75: Matched controls
749

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H74.9

ICD-10 Finland

Disorder of middle ear and mastoid, unspecified

+∞

30.2

H74.8

ICD-10 Finland

Other specified disorders of middle ear and mastoid

+∞

27.8

3858X

ICD-9 Finland

Other disorders of middle ear and mastoid

+∞

18.5

Z01.1

ICD-10 Finland

Examination of ears and hearing

11.2

15.2

UDC00

NOMESCO Finland

Ear microscopy

17.0

14.9

H65.2

ICD-10 Finland

Chronic serous otitis media

+∞

10.7

DCA20

NOMESCO Finland

Insertion of ventilating tube through tympanic membrane

63.3

9.9

H66.0

ICD-10 Finland

Acute suppurative otitis media

21.0

9.8

H65.3

ICD-10 Finland

Chronic mucoid otitis media

+∞

9.6

H71

ICD-10 Finland

Cholesteatoma of middle ear

+∞

9.6

DCA10

NOMESCO Finland

Paracentesis of tympanic membrane

56.7

8.9

DFF00

NOMESCO Finland

Pure tone audiometry

9.1

8.6

H66.9

ICD-10 Finland

Otitis media, unspecified

12.7

7.1

H60.3

ICD-10 Finland

Other infective otitis externa

18.9

6.9

H90.1

ICD-10 Finland

Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side

44.0

6.9

DC1AD

NOMESCO Finland

Temporalbone CT

+∞

6.3

3859X

ICD-9 Finland

Other disorders of middle ear and mastoid, Unspecified disorder of middle ear and mastoid

+∞

6.3

H74.1

ICD-10 Finland

Adhesive middle ear disease

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3007853) Bacteria identified in Skin by Aerobe culture

2.75

3.28

3.9

1.6

—

(3000494) Fungus identified in Specimen by Culture

2.45

1.5

1.4

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

6.56

2.40

1.0

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.43

2.20

1.3

1.4

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

160

2.02

2.17

1.3

2.0

1.2

mg/l

0.35

129

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

5.24

2.10

8.6

3.2

51.4

60.2

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

130

2.07

2.09

1.7

1.9

366667066.2

453.3

pmol/l

0.48

106

(3027273) Bicarbonate [Moles/volume] in Venous blood

3.03

2.07

3.7

5.1

24.0

24.3

mmol/l

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

3.03

2.07

4.9

5.1

45.0

47.3

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

115

2.11

2.07

1.4

1.3

31.9

43.7

iu/ml

—

(3020891) Body temperature

3.09

1.76

3.4

5.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.19

1.58

1.7

1.6

—

(3024354) Oxygen [Partial pressure] in Venous blood

2.33

1.58

3.0

5.8

4.3

4.2

kpa

0.12

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.53

1.51

3.1

5.6

130.4

129.9

g/l

—

(3012544) pH of Venous blood

2.17

1.46

2.9

6.9

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.08

1.42

1.7

—

(3002256) Pathology report gross observation

2.01

1.39

1.4

1.2

—

(3013707) Erythrocyte sedimentation rate by Westergren method

494

1.69

1.28

5.8

4.3

12.3

mm/h

0.00

455

(3007930) Methemoglobin/Hemoglobin.total in Blood

2.40

1.21

6.0

5.0

0.9

0.7

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

501

1.63

1.14

5.0

4.2

14.7

15.0

pmol/l

0.35

452

(3027945) Reticulocytes/100 erythrocytes in Blood

1.90

1.14

3.5

3.2

1.7

1.8

0.18

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

264

1.57

1.14

6.7

4.4

—

(42870588) Differential panel, method unspecified - Blood

210

1.59

1.12

10.1

5.7

—

(40760892) CBC W Ordered Manual Differential panel - Blood

149

1.65

1.10

7.7

5.6

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

1.96

1.08

3.1

6.9

5.8

kpa

0.09

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

108

1.72

1.07

1.4

1.3

1.7

9.6

u/ml

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

2.02

1.06

2.9

2.0

95.2

238.3

ng/l

—

(3005719) IgG [Mass/volume] in Serum or Plasma

2.01

1.06

5.0

2.1

9.5

10.4

g/l

—

(3021601) Nitrite [Presence] in Urine by Test strip

334

1.52

1.06

7.7

5.7

0.0

estimate

0.00

(3035350) Ketones [Presence] in Urine by Test strip

334

1.52

1.06

6.3

4.1

0.0

estimate

0.00

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.75

1.02

1.8

1.7

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

1.82

1.02

5.1

6.6

1.1

1.0

mmol/l

0.66

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

1.81

0.94

1.4

3.3

4.2

9.8

umol/l

1.63

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.89

0.92

1.9

2.8

0.2

g/l

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.00

0.92

1.9

1.1

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.71

0.91

1.4

1.5

—

(3009261) Glucose [Presence] in Urine by Test strip

342

1.46

0.90

6.2

4.1

0.0

estimate

—

(3000330) Specific gravity of Urine by Test strip

1.95

0.90

3.9

4.0

—

(3019060) Gas panel - Arterial blood

1.95

0.90

3.6

5.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.95

0.90

1.1

1.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

184

1.51

0.88

4.5

3.9

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.80

0.87

3.5

3.8

—

(3042936) Bacteria identified in Isolate by Culture

1.65

0.85

2.7

2.2

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.94

0.83

2.5

1.3

—

(3029937) Albumin [Presence] in Urine by Test strip

186

1.49

0.83

7.5

4.4

0.0

estimate

0.00

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

2.24

0.77

2.2

2.6

—

12873.0

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.92

0.76

1.0

—

(40761536) Microorganisms panel - Urine sediment

1.68

0.75

4.7

3.6

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

323

1.39

0.72

7.7

7.2

1.2

mmol/l

1.40

276

(3045414) Leukocytes [Presence] in Urine

1.83

0.67

3.0

1.5

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

260

1.38

0.65

2.3

1.9

84.6

97.7

pmol/l

1.19

124

(3032080) INR in Blood by Coagulation assay

251

1.38

0.64

17.1

8.7

1.4

1.3

inr

—

(40768793) Breast Pathology biopsy report

0.00

0.61

0.0

1.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.56

0.60

1.8

2.0

—

(3009214) Lutropin [Units/volume] in Serum or Plasma

0.00

0.59

0.0

1.2

—

16.1

—

(3037467) Urinalysis macro (dipstick) panel - Urine

464

1.33

0.54

7.4

4.6

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.58

0.54

2.5

9.9

92.2

93.2

—

(3018095) Leukocytes [#/volume] in Urine

258

1.32

0.53

2.9

3.6

63.7

59.2

e6/l

0.03

179

(3044889) 12 lead EKG panel

445

1.31

0.52

5.3

3.9

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

0.60

0.48

4.8

32.4

33.1

—

(3009542) Hematocrit [Volume Fraction] of Blood

593

1.36

0.48

18.8

15.6

40.1

39.2

0.55

437

(3000991) Gas panel - Venous blood

1.47

0.47

2.3

9.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

262

1.29

0.46

5.5

3.1

—

(4035726)

1.50

0.44

1.0

1.5

—

(3020630) Protein [Mass/volume] in Serum or Plasma

1.50

0.44

2.3

1.4

72.2

65.7

g/l

—

(36304419) Bacteria [Presence] in Urine

197

1.31

0.44

2.6

2.7

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.65

0.44

1.6

1.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

115

1.37

0.42

1.5

1.7

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.41

0.0

3.2

—

106.1

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.41

0.0

3.2

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.41

0.0

3.2

—

4.0

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.41

0.0

1.5

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.41

0.0

1.5

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.7

—

(4034850)

0.00

0.41

0.0

9.1

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.40

0.0

1.3

—

(3006184) Hemoglobin [Mass/volume] in Capillary blood

0.00

0.40

0.0

2.1

—

127.1

—

(3009508) Creatinine [Moles/volume] in Urine

200

1.28

0.39

1.6

2.9

8.1

7.4

mmol/l

0.23

161

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.39

0.0

1.7

—

6.2

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.41

0.39

2.0

3.9

1.7

0.9

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.41

0.39

1.2

1.4

—

(3003694) ABO and Rh group [Type] in Blood

182

1.28

0.38

1.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

173

1.29

0.37

6.8

3.6

—

(3018418) pH of Serum or Plasma

211

1.26

0.37

6.2

4.0

7.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

127

1.32

0.37

1.4

1.6

—

(3023368) Bacteria identified in Blood by Culture

174

1.28

0.36

5.7

4.0

—

(40768804) Tissue Pathology biopsy report

290

1.23

0.34

2.6

2.0

—

(40768797) Stomach Pathology biopsy report

1.35

0.34

1.0

1.2

—

(3003338) MCHC [Mass/volume]

565

1.23

0.29

27.6

19.2

331.8

331.1

g/l

0.25

565

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

426

0.84

0.29

3.3

2.9

—

(3012516) Albumin [Mass/volume] in Urine

189

1.22

0.28

1.8

2.9

80.6

64.8

mg/l

0.08

120

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

0.69

0.25

4.0

2.8

14.8

20.6

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

673

1.27

0.25

23.3

16.1

139.7

139.8

mmol/l

0.06

659

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

621

1.22

0.24

18.1

13.7

82.2

80.3

ml/min/173m2

0.31

497

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

182

1.20

0.24

2.0

1.8

1.4

mmol/l

0.06

155

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

328

1.17

0.24

4.1

3.7

—

(3022948) Iron [Moles/volume] in Serum or Plasma

0.72

0.24

3.4

2.7

10.8

12.3

umol/l

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.30

0.23

17.5

8.4

—

(3044640) Blood type and Crossmatch panel - Blood

213

1.18

0.21

1.8

2.0

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.21

0.0

2.6

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.21

0.0

1.4

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.21

0.0

2.5

—

2.7

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.1

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.1

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

31.8

—

(3026008) Bacteria identified in Urine by Culture

233

1.17

0.21

4.8

2.9

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

676

1.23

0.21

23.9

16.0

4.0

mmol/l

0.26

658

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.27

0.21

1.3

1.7

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.20

0.0

1.5

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.8

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.20

0.0

1.5

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.20

0.0

1.5

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.20

0.0

1.5

—

(40767503) Oxygen content in Capillary blood by calculation

0.00

0.20

0.0

2.9

—

15.8

—

(3019225) pH of Specimen

1.19

0.20

3.3

3.6

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.14

0.18

2.3

2.8

29.3

28.8

u/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.14

0.16

1.7

1.4

—

(40758558) Short blood count panel - Blood

188

1.16

0.16

8.3

7.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.75

0.16

2.0

—

(3022145) Colonoscopy Study observation

0.80

0.15

1.3

—

(3026361) Erythrocytes [#/volume] in Blood

732

1.27

0.15

32.0

21.1

4.4

4.5

e12/l

0.50

713

(3000963) Hemoglobin [Mass/volume] in Blood

732

1.27

0.15

32.1

21.2

132.4

134.6

g/l

0.64

721

(3007461) Platelets [#/volume] in Blood

732

1.27

0.15

32.0

21.1

246.0

250.6

e9/l

0.26

717

(3035941) MCH [Entitic mass]

732

1.27

0.15

31.9

21.0

30.0

30.2

0.44

723

(3024731) MCV [Entitic volume]

732

1.27

0.15

31.9

21.0

90.3

91.0

0.75

723

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

152

1.15

0.13

1.8

1.9

—

(40761511) CBC panel - Blood by Automated count

693

1.17

0.12

22.4

12.4

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.17

0.10

2.0

1.3

—

(1761868) Lipid panel - Serum or Plasma

224

1.10

0.09

3.4

2.9

—

(40761535) Cells panel - Urine sediment

1.14

0.09

13.3

3.4

—

(3013512) EKG study

185

1.11

0.09

3.5

4.1

—

(3022621) pH of Urine by Test strip

0.77

0.08

3.8

2.2

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

166

1.11

0.08

1.2

1.3

0.7

0.8

u/ml

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

0.82

0.08

1.8

1.5

1.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.79

0.08

2.0

1.9

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

112

0.88

0.08

1.6

1.4

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

661

0.91

0.06

22.0

14.5

19.8

23.1

mg/l

0.51

527

(3002385) Erythrocyte distribution width [Ratio]

570

1.06

0.03

26.0

17.4

13.8

13.6

0.26

561

(3020682) Albumin/Creatinine [Ratio] in Urine

203

1.04

0.01

2.3

3.7

20.8

10.0

mg/mmol

0.36

122

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

126

1.04

0.00

5.9

4.7

21.2

21.1

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

696

1.03

0.00

25.4

16.6

77.5

75.6

umol/l

0.16

696

(3000492) Spirometry study

0.94

0.00

1.0

1.5

—

(3017732) Neutrophils [#/volume] in Blood

0.94

0.00

2.0

2.8

4.2

4.1

e9/l

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.0

1.0

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

1.0

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

1.4

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(4306422)

0.00

0.0

1.1

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

9.2

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

2.7

—

91.5

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(4268621)

0.00

0.0

1.8

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.1

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3020491) Glucose [Moles/volume] in Blood

0.00

0.0

2.4

—

6.1

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3026285) Alpha 1 antitrypsin [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

1.3

—

(3035880) pH of Pleural fluid

0.00

0.0

1.2

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.0

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

1.0

—

100.3

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(40757494) Bilirubin.total [Moles/volume] in Blood

0.00

0.0

1.8

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

2.2

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.0

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.1

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.9

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

21.0

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.4

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

1.2

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.0

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

1.4

—

(3020876) Protein [Mass/time] in 24 hour Urine

0.00

0.0

1.6

—

(4211845)

0.00

0.0

1.6

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.2

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.4

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.1

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.1

—

107.3

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.1

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

1.9

—

Mortality – FinRegistry

↥

Association

Association between endpoint H8_MIDDMASTNAS and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
H8_MIDDMASTNAS	1.128 [0.74, 1.72]	0.576
Birth year	0.982 [0.97, 0.99]	< 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 259 males with H8_MIDDMASTNAS died.

Mortality risk

Mortality risk for people of age

years, who have H8_MIDDMASTNAS.

N-year risk	Females	Males
1	No data	0.187%
5	No data	1.065%
10	No data	2.818%
15	No data	5.374%
20	No data	9.128%

Relationships between endpoints

↥

Index endpoint: H8_MIDDMASTNAS – Other specified/unspecified disorders of middle ear and mastoid

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other specified/unspecified disorders of middle ear and mastoid

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints