Other infective spondylopathies

M13_SPONDYLOINFECTION

spondyloarthropathy: A group of inflammatory rheumatic diseases associated with arthritis and enthesitis, and often involving the axial skeleton. The most common form of spondyloarthritis is ankylosing spondylitis. Other forms include axial spondyloarthritis, peripheral spondyloarthritis, reactive arthritis, psoriatic arthritis/spondylitis and enteropathic arthritis/spondylitis.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M46.5 Cause of death: ICD-10 — M46.5 2 out of 7 registries used, show all original rules.	76
4. Check minimum number of events None	76
5. Include endpoints None	76
6. Filter based on genotype QC (FinnGen only)	76

Control definitions (FinnGen only)

Control exclude: M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M46
Name in latin: Aliae spondylopathiae infectiosae

NAME	M13_SPONDYLOINFECTION
CONTROL_EXCLUDE	M13_DORSOPATHY
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M465
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M465
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other infective spondylopathies based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	542	218	318
Only index persons	472	194	278
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	62.03	62.76	61.63
Only index persons	61.15	61.14	61.16

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	76	36	40
Unadjusted period prevalence (%)	0.02	0.01	0.02
Median age at first event (years)	61.74	61.75	61.74

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
69: Matched controls
691

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M46.5

ICD-10 Finland

Other infective spondylopathies

+∞

99.1

M46.4

ICD-10 Finland

Discitis, unspecified

+∞

19.7

M48.0

ICD-10 Finland

Spinal stenosis

128.5

18.6

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

85.7

17.8

N02AX02

ATC

tramadol; systemic, rectal

9.7

16.6

156

M46.3

ICD-10 Finland

Infection of intervertebral disc (pyogenic)

+∞

16.3

N03AX16

ATC

pregabalin; oral

8.2

12.3

ABC36

NOMESCO Finland

Decompression of lumbar nerve roots

+∞

11.8

M46.9

ICD-10 Finland

Inflammatory spondylopathy, unspecified

+∞

10.7

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

+∞

10.7

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

64.4

10.0

A41.0

ICD-10 Finland

Sepsis due to Staphylococcus aureus

35.7

9.8

J01FF01

ATC

clindamycin; systemic

5.3

9.2

106

M54.5

ICD-10 Finland

Low back pain

5.3

8.3

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

4.7

8.3

130

N02AA05

ATC

oxycodone; systemic

6.1

8.3

J04AB02

ATC

rifampicin; systemic

51.0

7.9

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

13.0

7.7

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

7.7

7.4

M54.2

ICD-10 Finland

Cervicalgia

25.5

6.9

M45

ICD-10 Finland

Ankylosing spondylitis

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

11.00

11.09

1.7

1.5

—

(3023368) Bacteria identified in Blood by Culture

158

4.96

11.04

9.8

3.9

—

(3042936) Bacteria identified in Isolate by Culture

4.68

8.81

2.9

1.9

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

6.27

8.34

1.6

1.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

211

3.39

6.42

4.7

3.1

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

5.09

6.36

2.9

2.6

ml/min/173m2

40.7

51.8

—

(42870588) Differential panel, method unspecified - Blood

185

3.28

6.08

11.0

4.9

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

12.56

5.99

2.0

1.0

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

4.81

5.95

2.2

1.5

—

(3022217) INR in Platelet poor plasma by Coagulation assay

3.74

5.93

18.0

25.4

inr

1.3

1.5

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

6.25

5.48

1.7

1.4

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

4.69

5.13

15.5

8.3

mmol/l

26.3

24.8

0.75

(3026008) Bacteria identified in Urine by Culture

172

2.92

4.91

5.5

3.1

—

(1616796) Gas panel - Central venous blood

12.57

4.90

5.1

3.3

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

328

3.03

4.80

18.0

9.7

e9/l

4.8

4.1

1.09

295

(3044640) Blood type and Crossmatch panel - Blood

184

2.82

4.64

2.5

2.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

3.19

4.55

2.9

1.8

—

(3021901) Oxygen saturation in Capillary blood

12.66

4.36

2.1

3.5

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

259

2.66

4.19

5.1

3.7

—

(3018095) Leukocytes [#/volume] in Urine

209

2.64

4.14

4.5

3.7

e6/l

27.8

67.2

0.82

149

(3002582) Erythrocytes [#/volume] in Urine

185

2.65

4.13

3.8

3.3

e6/l

22.4

407.8

0.55

139

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

3.42

4.02

3.6

1.8

g/l

0.2

0.88

(3027315) Oxygen [Partial pressure] in Blood

9.48

3.86

8.3

1.5

kpa

9.1

9.0

—

(3013290) Carbon dioxide [Partial pressure] in Blood

9.48

3.86

8.3

1.5

kpa

5.4

5.2

—

(3030467) Casts [#/volume] in Urine by Automated count

162

2.54

3.66

4.1

3.1

e6/l

0.3

0.4

0.16

122

(3020891) Body temperature

4.28

3.65

10.4

2.9

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

8.42

3.64

1.0

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

2.75

3.55

4.0

2.8

e6/l

2.4

1.7

0.23

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

7.57

3.44

1.3

1.2

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

6.24

3.44

1.1

1.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.00

3.30

3.1

1.7

—

(3037467) Urinalysis macro (dipstick) panel - Urine

387

2.52

3.25

5.5

4.1

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

281

2.34

3.24

14.5

6.5

mmol/l

1.2

0.62

231

(3011397) Hemoglobin [Presence] in Urine by Test strip

110

2.56

3.21

8.4

3.8

—

(3004588) Protein electrophoresis panel - Serum or Plasma

3.28

3.21

4.8

2.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.95

3.20

3.1

1.7

—

(3021788) Differential panel - Synovial fluid

8.02

3.11

2.7

1.4

—

(3021589) Normoblasts [#/volume] in Blood

258

2.28

3.08

22.3

8.9

e9/l

0.0

0.71

218

(3028271) Lactate [Moles/volume] in Capillary blood

10.57

3.02

1.8

1.4

mmol/l

2.0

1.4

—

(36304419) Bacteria [Presence] in Urine

152

2.33

2.95

4.4

2.9

—

(3014007) Fractional oxyhemoglobin in Arterial blood

3.40

2.94

21.4

8.9

93.6

94.4

0.31

(3048929) Epstein Barr virus Ab [Presence] in Serum

5.81

2.94

1.3

1.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.87

2.91

1.2

1.6

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

4.29

2.88

1.9

2.0

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

2.53

2.87

4.1

3.0

e6/l

2.5

2.0

0.11

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

140

2.30

2.77

2.6

2.2

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

6.40

2.75

1.3

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

6.40

2.75

1.3

—

(3019060) Gas panel - Arterial blood

3.22

2.71

5.9

2.7

—

(40768797) Stomach Pathology biopsy report

2.59

2.68

1.2

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

261

2.12

2.63

7.1

3.9

g/l

31.9

35.5

2.72

243

(3044290) Cell count panel - Cerebral spinal fluid

7.54

2.59

1.0

1.1

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.67

2.58

1.3

1.4

—

(3023183) Ammonium ion [Moles/volume] in Plasma

5.32

2.45

1.8

1.6

umol/l

34.7

34.3

—

(3018405) Lactate [Moles/volume] in Arterial blood

3.94

2.44

6.4

2.3

mmol/l

0.9

1.6

—

(3000494) Fungus identified in Specimen by Culture

2.59

2.43

1.7

1.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

124

2.23

2.41

8.5

5.9

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

6.59

2.41

1.0

—

(3025941) Bacteria identified in Stool by Culture

3.50

2.40

1.3

1.2

—

(40758558) Short blood count panel - Blood

148

2.15

2.39

10.8

6.6

—

(3037522) Nuclear Ab [Titer] in Serum

2.54

2.36

1.6

1.4

titre

240.0

344.0

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.65

2.27

1.8

1.6

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

2.40

2.22

4.7

5.2

mmol/l

1.2

1.0

0.54

(3042111) Morphology [Interpretation] in Bone marrow Narrative

4.55

2.19

1.2

1.7

—

(3034770) Mitochondria Ab [Titer] in Serum

4.55

2.19

1.3

1.1

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

239

1.96

2.14

1.8

1.9

pmol/l

93.4

87.8

0.27

112

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

5.26

2.10

2.6

4.2

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.33

2.09

1.5

1.8

—

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.05

2.08

4.0

1.1

g/l

9.2

10.6

—

(3032080) INR in Blood by Coagulation assay

251

1.92

2.05

12.0

7.2

inr

1.7

1.3

0.37

(3005719) IgG [Mass/volume] in Serum or Plasma

2.80

2.01

8.2

2.7

g/l

10.0

9.7

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.80

2.01

23.2

8.3

1.6

1.2

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.80

2.01

23.2

8.3

0.6

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.95

2.01

2.0

1.1

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

299

1.90

1.99

3.3

2.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.45

1.97

6.5

2.5

—

(21494755) Public health laboratory ask at order entry panel

0.00

1.97

0.0

1.4

—

(40761535) Cells panel - Urine sediment

2.73

1.92

14.5

3.7

—

(3035350) Ketones [Presence] in Urine by Test strip

275

1.86

1.87

7.7

3.5

estimate

0.0

—

(3000991) Gas panel - Venous blood

2.45

1.85

21.0

7.3

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.59

1.76

5.9

2.2

0.6

0.7

—

(3009261) Glucose [Presence] in Urine by Test strip

280

1.81

1.73

7.9

3.5

estimate

0.0

—

(3021601) Nitrite [Presence] in Urine by Test strip

280

1.81

1.73

10.2

4.9

estimate

0.0

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.53

1.68

6.8

2.2

1.2

—

(3012544) pH of Venous blood

2.21

1.60

5.9

2.6

—

(3018418) pH of Serum or Plasma

177

1.81

1.59

7.5

4.0

7.4

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

3.49

1.55

1.8

1.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

1.97

1.50

2.3

1.6

g/l

4.3

2.3

0.86

(3002256) Pathology report gross observation

2.13

1.49

1.4

1.2

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

2.21

1.41

8.9

3.9

mmol/l

1.2

0.40

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.74

1.39

3.2

3.0

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.29

1.39

1.1

1.5

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.90

1.30

1.8

2.4

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.74

1.23

1.2

1.4

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.74

1.23

1.4

1.8

—

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

2.42

1.21

1.5

1.0

g/l

31.4

39.0

—

(40768804) Tissue Pathology biopsy report

226

1.63

1.20

2.2

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

1.19

0.0

1.4

—

(3000330) Specific gravity of Urine by Test strip

2.12

1.16

7.1

4.5

—

(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.46

1.16

1.4

1.1

g/l

3.8

2.8

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

106

1.78

1.15

6.5

3.1

mmol/l

0.8

0.36

100

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

1.87

1.14

1.1

1.2

u/ml

0.8

25.0

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

1.81

1.10

1.3

1.2

iu/ml

55.6

42.4

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

258

1.58

1.10

6.1

3.5

ng/l

30.9

54.9

0.77

190

(3012516) Albumin [Mass/volume] in Urine

212

1.59

1.10

2.9

3.2

mg/l

49.0

67.0

0.31

133

(3019225) pH of Specimen

2.02

1.07

4.8

3.8

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

2.36

1.05

1.6

1.2

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

595

1.83

0.96

44.7

12.9

mg/l

36.0

23.1

1.91

459

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.24

0.94

31.2

7.6

—

(3022621) pH of Urine by Test strip

1.96

0.91

3.3

2.8

—

(3009508) Creatinine [Moles/volume] in Urine

214

1.49

0.84

2.9

3.2

mmol/l

6.0

7.7

2.16

181

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.83

0.78

4.3

1.6

—

(3045414) Leukocytes [Presence] in Urine

2.25

0.77

2.4

1.8

—

(3029937) Albumin [Presence] in Urine by Test strip

146

1.50

0.74

9.9

3.7

estimate

0.0

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

626

0.69

0.60

5.3

5.2

mmol/l

2.5

2.6

0.53

560

(1002224) Polysomnography panel

0.00

0.59

0.0

1.1

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.57

0.57

1.1

1.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

219

1.36

0.56

9.6

3.7

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.52

0.51

1.2

1.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

532

1.38

0.51

39.2

14.3

39.1

40.0

0.30

366

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.61

0.50

1.6

1.4

—

(40761536) Microorganisms panel - Urine sediment

1.54

0.49

5.6

3.4

—

(1761868) Lipid panel - Serum or Plasma

214

0.74

0.46

3.4

3.2

—

(3020682) Albumin/Creatinine [Ratio] in Urine

225

1.31

0.46

3.7

4.1

mg/mmol

8.4

11.9

0.26

138

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.41

0.0

1.6

—

(36660697) Celiac disease serology panel - Serum

1.46

0.40

1.2

—

(3013512) EKG study

191

1.29

0.40

5.3

4.1

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.39

0.0

1.5

—

0.8

—

(3044889) 12 lead EKG panel

434

1.22

0.30

4.1

3.9

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

416

1.20

0.28

3.0

3.8

pmol/l

14.6

15.2

0.61

364

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.38

0.24

1.0

1.2

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.21

0.0

1.9

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

638

1.26

0.21

42.6

15.3

mmol/l

139.1

139.7

1.20

614

(4035726)

1.16

0.18

1.4

1.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.16

0.16

14.2

7.3

—

(3007461) Platelets [#/volume] in Blood

674

0.84

0.11

53.8

19.3

e9/l

251.1

243.9

0.30

654

(3035941) MCH [Entitic mass]

674

0.84

0.11

53.5

19.2

30.0

30.4

1.25

661

(3024731) MCV [Entitic volume]

674

0.84

0.11

53.7

19.3

91.4

91.3

0.06

661

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

574

1.12

0.10

33.8

13.0

ml/min/173m2

79.1

76.8

0.35

467

(3022145) Colonoscopy Study observation

1.04

0.08

1.2

1.3

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

186

1.10

0.08

4.1

4.2

24.8

22.1

—

(3003694) ABO and Rh group [Type] in Blood

137

1.12

0.08

1.3

—

(40761511) CBC panel - Blood by Automated count

623

0.89

0.08

27.9

12.5

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

649

1.13

0.06

42.9

16.1

umol/l

77.4

80.1

0.40

649

(3002385) Erythrocyte distribution width [Ratio]

492

1.05

0.02

47.2

16.5

14.5

13.8

2.34

486

(3041096) Erythrocytes [Presence] in Urine by Automated

167

1.02

0.00

6.3

3.2

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.1

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.1

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.9

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

4.8

—

(3000492) Spirometry study

0.96

0.00

1.2

1.7

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

5.0

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

2.8

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.0

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

2.9

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

4.8

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.0

2.4

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.0

1.3

—

(4010399)

0.98

0.00

1.8

1.5

—

(3000034) Microalbumin [Mass/volume] in Urine

0.00

0.0

6.2

—

36.8

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.0

1.8

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

4.8

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_SPONDYLOINFECTION and mortality.

Females

Parameter	HR [95% CI]	p-value
M13_SPONDYLOINFECTION	1.757 [1.21, 2.55]	0.003
Birth year	0.998 [0.99, 1.01]	0.609

During the follow-up period (1.1.1998 — 31.12.2019), 73 out of 189 females with M13_SPONDYLOINFECTION died.

Males

Parameter	HR [95% CI]	p-value
M13_SPONDYLOINFECTION	1.879 [1.35, 2.62]	< 0.001
Birth year	0.986 [0.98, 1.0]	0.003

During the follow-up period (1.1.1998 — 31.12.2019), 102 out of 266 males with M13_SPONDYLOINFECTION died.

Mortality risk

Mortality risk for people of age

years, who have M13_SPONDYLOINFECTION.

N-year risk	Females	Males
1	0.202%	0.326%
5	1.082%	2.174%
10	2.763%	5.34%
15	5.439%	9.837%
20	9.668%	17.039%

Relationships between endpoints

↥

Index endpoint: M13_SPONDYLOINFECTION – Other infective spondylopathies

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other infective spondylopathies

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints