Traumatic amputation of ankle and foot

ST19_TRAUMAT_AMPUT_ANKLE_FOOT

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — S98 Cause of death: ICD-10 — S98 2 out of 7 registries used, show all original rules.	88
4. Check minimum number of events None	88
5. Include endpoints None	88
6. Filter based on genotype QC (FinnGen only)	88

Control definitions (FinnGen only)

Control exclude: ST19_INJURI_ANKLE_FOOT

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: S90
Name in latin: Amputatio traumatica tarsi/pedis

NAME	ST19_TRAUMAT_AMPUT_ANKLE_FOOT
CONTROL_EXCLUDE	ST19_INJURI_ANKLE_FOOT
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	S98
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	S98
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Traumatic amputation of ankle and foot based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	88	22	66
Unadjusted period prevalence (%)	0.02	0.01	0.03
Median age at first event (years)	54.68	54.25	54.82

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
81: Matched controls
811

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

S98.1

ICD-10 Finland

Traumatic amputation of one toe

+∞

57.2

S98.2

ICD-10 Finland

Traumatic amputation of two or more toes

+∞

24.2

NHQ40

NOMESCO Finland

Amputation of toe

41.7

19.7

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

39.4

18.7

QDB05

NOMESCO Finland

Revision of wound of skin of lower limb

52.2

17.3

W31

ICD-10 Finland

Contact with other and unspecified machinery

15.0

10.4

QDG20

NOMESCO Finland

Operation for chronic ulcer or fistula of skin of lower limb

62.8

9.9

L97

ICD-10 Finland

Ulcer of lower limb, not elsewhere classified

34.7

9.7

A46

ICD-10 Finland

Erysipelas

7.1

9.7

NHQ30

NOMESCO Finland

Amputation of foot, transmetatarsal

56.3

8.9

M86.9

ICD-10 Finland

Osteomyelitis, unspecified

+∞

8.5

SPAT1148

SPAT

Treatment of chronic ulcer or burn

6.0

8.3

S92.5

ICD-10 Finland

Fracture of other toe

37.5

8.3

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

9.0

8.2

NHQ48

NOMESCO Finland

Revision of amputation of toe

+∞

7.4

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

6.0

6.9

NGQ20

NOMESCO Finland

Amputation of lower leg

+∞

6.3

S98.4

ICD-10 Finland

Traumatic amputation of foot, level unspecified

+∞

6.3

ZZA00

NOMESCO Finland

Split skin graft

14.0

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3007853) Bacteria identified in Skin by Aerobe culture

3.80

6.33

3.3

1.7

—

(3009508) Creatinine [Moles/volume] in Urine

209

2.68

4.79

3.0

7.1

8.3

mmol/l

1.03

178

(3042936) Bacteria identified in Isolate by Culture

3.14

4.78

3.7

1.7

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

10.72

4.08

1.0

1.3

—

(3020682) Albumin/Creatinine [Ratio] in Urine

212

2.29

3.41

3.8

3.7

13.8

10.9

mg/mmol

0.16

139

(3012516) Albumin [Mass/volume] in Urine

194

2.23

3.12

3.0

3.1

108.3

432.4

mg/l

0.45

129

(3000093) Morphology [Interpretation] in Blood Narrative

8.73

2.78

1.0

1.2

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

4.97

2.65

1.4

1.3

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

195

1.91

2.07

2.8

3.2

2595.0

1104.9

ng/l

0.39

169

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

3.53

2.01

1.3

2.0

—

(3032080) INR in Blood by Coagulation assay

295

1.81

1.97

12.1

7.4

1.3

1.2

inr

0.11

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

4.75

1.97

1.2

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

3.36

1.92

1.1

1.6

—

(3023368) Bacteria identified in Blood by Culture

185

1.85

1.83

6.8

4.5

—

(3016879) Cocaine [Presence] in Urine

2.73

1.70

1.6

1.5

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

279

1.64

1.41

3.7

53.1

46.5

ng/l

0.08

192

(1001926) Buprenorphine [Presence] in Urine by Screen method

2.72

1.39

1.8

—

(3000764) Benzodiazepines [Presence] in Urine

2.48

1.33

1.8

1.5

—

(4034850)

2.61

1.33

12.2

17.9

—

(3028300) Cannabinoids [Presence] in Urine

2.41

1.31

1.8

1.5

—

(3027008) Opiates [Presence] in Urine

2.41

1.31

1.8

1.5

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

110

1.80

1.28

1.7

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.73

1.23

1.4

1.7

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.13

1.22

1.3

1.5

—

(3009542) Hematocrit [Volume Fraction] of Blood

645

0.64

1.15

24.8

13.9

42.0

40.8

0.66

493

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

226

1.57

1.15

2.7

2.4

49.2

53.9

u/l

0.54

216

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.77

1.13

2.3

1.7

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.22

1.08

2.0

1.6

—

(3027944) Amphetamines [Presence] in Urine

2.08

1.02

1.6

1.5

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

325

1.49

1.02

8.5

3.6

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.89

1.00

1.3

1.5

—

(3044640) Blood type and Crossmatch panel - Blood

224

1.51

0.99

8.0

2.1

—

(40768804) Tissue Pathology biopsy report

243

0.63

0.91

1.6

2.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

274

1.46

0.91

3.4

—

(3044889) 12 lead EKG panel

483

1.44

0.84

3.7

3.6

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.94

0.83

4.7

7.1

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

424

1.42

0.82

2.7

3.0

—

(3008898) HLA-B27 [Presence]

0.00

0.80

0.0

1.0

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.73

0.79

4.0

2.7

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

236

1.41

0.74

2.1

2.2

66.0

71.2

nmol/l

0.51

207

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.77

0.72

1.4

1.3

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.98

0.72

4.2

2.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.68

0.68

1.4

1.5

—

(3026008) Bacteria identified in Urine by Culture

159

1.42

0.63

2.7

2.3

—

(3013512) EKG study

178

1.40

0.61

4.7

4.1

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

0.00

0.61

0.0

2.3

—

69.6

—

(40768797) Stomach Pathology biopsy report

1.52

0.59

1.3

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.59

0.0

1.7

—

4.4

—

(40768800) Prostate Pathology biopsy report

0.00

0.59

0.0

1.3

—

(42870588) Differential panel, method unspecified - Blood

226

1.35

0.58

7.2

5.5

—

(3022313) Gas panel - Capillary blood

1.71

0.58

5.0

2.3

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.71

0.58

1.5

2.8

—

(3012544) pH of Venous blood

1.53

0.56

3.9

3.4

—

(3015736) pH of Urine

256

1.33

0.55

3.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

164

1.37

0.53

4.8

2.0

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

229

0.73

0.51

1.4

2.9

0.5

0.7

ug/l

—

149

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.48

0.50

2.4

1.6

—

(1761868) Lipid panel - Serum or Plasma

281

0.75

0.50

3.3

2.6

—

(3023520) Reticulocytes [#/volume] in Blood

1.57

0.50

5.3

1.8

81.4

78.1

e9/l

—

(3009261) Glucose [Presence] in Urine by Test strip

348

1.27

0.48

3.4

0.0

estimate

—

(40761535) Cells panel - Urine sediment

1.46

0.47

2.7

3.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

460

1.26

0.44

4.2

3.8

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

245

1.27

0.43

1.6

1.9

85.6

90.7

pmol/l

—

112

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.60

0.43

2.2

1.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.42

0.42

1.2

1.4

—

(3007164) IgA [Mass/volume] in Serum or Plasma

124

1.35

0.42

1.1

1.3

3.3

2.6

g/l

—

(3000991) Gas panel - Venous blood

1.39

0.42

6.6

9.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

115

1.37

0.42

2.6

1.8

—

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

0.00

0.41

0.0

1.7

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.41

0.0

1.4

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

0.00

0.41

0.0

1.3

—

620.9

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.41

0.0

1.2

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

670

1.31

0.39

4.6

4.4

6.2

6.1

mmol/l

0.52

620

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.41

0.39

1.0

2.7

122.0

131.4

g/l

—

(3035350) Ketones [Presence] in Urine by Test strip

338

1.22

0.35

3.6

3.4

0.0

estimate

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.39

0.35

3.7

11.6

94.7

94.4

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

652

1.27

0.35

7.4

5.4

41.3

40.4

mmol/mol

0.26

617

(3022145) Colonoscopy Study observation

0.67

0.35

1.2

1.4

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

147

1.28

0.34

3.0

3.2

—

(3020630) Protein [Mass/volume] in Serum or Plasma

1.33

0.34

1.7

3.2

64.0

67.6

g/l

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

479

1.21

0.33

4.8

3.1

62.4

52.2

u/l

0.28

456

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.27

0.30

2.3

1.9

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

104

1.29

0.28

3.2

3.3

2.4

mmol/l

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

754

1.30

0.26

23.0

15.5

87.7

82.4

umol/l

0.32

754

(3000494) Fungus identified in Specimen by Culture

1.20

0.25

1.6

1.4

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.30

0.23

8.2

4.7

23.0

24.8

mmol/l

—

(40761511) CBC panel - Blood by Automated count

735

1.25

0.23

22.6

12.7

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.5

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.21

0.0

1.6

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.21

0.0

2.1

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.21

0.0

3.3

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.21

0.0

1.5

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.21

0.0

1.4

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

59.9

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.21

0.0

1.5

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.21

0.0

1.5

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.21

0.0

1.3

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.7

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.7

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.21

0.0

1.7

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.5

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.4

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.21

0.0

1.7

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

1.30

0.21

2.5

3.2

—

60.4

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.21

0.0

1.2

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.5

—

(36660697) Celiac disease serology panel - Serum

1.27

0.21

1.0

1.3

—

(3021601) Nitrite [Presence] in Urine by Test strip

341

1.15

0.20

4.6

4.5

0.0

estimate

—

(40768793) Breast Pathology biopsy report

0.00

0.20

0.0

1.6

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.20

0.0

1.4

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.20

0.0

1.8

—

(3050449) Albumin [Mass/time] in Urine collected for unspecified duration

0.00

0.20

0.0

2.9

—

135.0

—

(3019060) Gas panel - Arterial blood

1.19

0.20

2.3

4.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.26

0.20

2.0

1.6

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

696

1.19

0.19

25.0

13.1

22.3

25.5

mg/l

0.41

544

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

388

0.88

0.19

3.5

4.7

1.7

1.9

ug/l

0.21

345

(3003694) ABO and Rh group [Type] in Blood

186

1.17

0.19

1.3

1.4

—

(3019225) pH of Specimen

1.25

0.19

19.7

3.8

—

(3022621) pH of Urine by Test strip

1.18

0.18

3.6

2.2

—

(3027945) Reticulocytes/100 erythrocytes in Blood

1.18

0.17

3.6

2.1

2.5

1.9

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

1.16

0.17

4.4

3.7

242.5

237.4

u/l

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

140

1.17

0.16

1.2

1.7

1.2

mg/l

0.24

119

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.19

0.16

12.7

8.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

248

1.13

0.15

3.8

2.9

—

(36304419) Bacteria [Presence] in Urine

189

0.88

0.13

4.6

2.6

—

(3018095) Leukocytes [#/volume] in Urine

250

0.89

0.13

4.6

3.3

103.8

66.0

e6/l

0.24

188

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.20

0.13

2.0

1.7

—

(3022948) Iron [Moles/volume] in Serum or Plasma

116

0.84

0.12

4.6

2.3

11.5

14.0

umol/l

—

108

(3019309) Folate [Moles/volume] in Red Blood Cells

115

1.15

0.11

2.0

1.6

1979.6

1203.2

nmol/l

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

116

1.14

0.10

3.2

2.4

1.2

1.3

e6/l

—

(40761536) Microorganisms panel - Urine sediment

1.12

0.09

2.5

4.3

—

(4010399)

1.12

0.09

1.5

1.4

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

113

0.87

0.09

3.5

2.4

1.1

1.0

e6/l

—

(3002256) Pathology report gross observation

0.85

0.08

1.2

1.3

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

732

0.91

0.07

27.3

14.8

4.0

mmol/l

0.66

710

(3019550) Sodium [Moles/volume] in Serum or Plasma

729

0.93

0.03

27.1

14.7

139.2

139.7

mmol/l

0.98

710

(3041096) Erythrocytes [Presence] in Urine by Automated

211

1.06

0.03

3.1

3.0

—

(3026782) Osmolality of Urine

138

0.93

0.02

3.7

2.7

422.0

594.4

mosm/kgh2o

—

123

(40758558) Short blood count panel - Blood

182

1.06

0.02

6.2

6.4

—

(3030467) Casts [#/volume] in Urine by Automated count

192

1.05

0.02

4.1

2.8

0.3

0.4

e6/l

0.52

145

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

652

1.05

0.02

17.8

12.5

80.3

82.9

ml/min/173m2

0.36

541

(3029937) Albumin [Presence] in Urine by Test strip

183

1.05

0.01

3.9

3.6

0.0

estimate

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

134

1.05

0.00

2.3

1.9

481.6

428.6

pmol/l

0.24

119

(40760892) CBC W Ordered Manual Differential panel - Blood

153

0.98

0.00

12.5

4.9

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

303

0.98

0.00

3.6

4.4

24.8

20.8

—

142

(3002582) Erythrocytes [#/volume] in Urine

221

0.99

0.00

4.0

2.9

19.4

317.6

e6/l

0.53

174

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

0.0

1.5

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.02

0.00

2.2

1.7

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3024731) MCV [Entitic volume]

790

1.00

0.00

33.8

19.2

91.6

90.9

0.65

779

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

5.9

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.4

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

1.0

—

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.4

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

2.7

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

3.1

—

100.9

—

(3011985) Renin [Units/volume] in Plasma

0.00

0.0

1.2

—

21.4

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

263.3

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.2

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.0

1.4

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.4

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.2

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3029023) Hepatitis E virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3035941) MCH [Entitic mass]

791

0.99

0.00

33.8

19.2

30.4

0.03

780

(21494755) Public health laboratory ask at order entry panel

0.90

0.00

1.4

1.5

—

(3026361) Erythrocytes [#/volume] in Blood

791

0.99

0.00

34.0

19.3

4.4

4.6

e12/l

1.44

769

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

(3000492) Spirometry study

0.96

0.00

1.3

1.5

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.2

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.4

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.4

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

2.0

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.4

—

(3034426) Prothrombin time (PT)

0.00

0.0

1.2

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

2.7

—

4.1

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.0

1.1

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.6

—

(3010813) Leukocytes [#/volume] in Blood

791

0.99

0.00

34.1

19.4

7.0

6.7

e9/l

0.80

771

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

2.7

—

107.6

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

0.0

1.6

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.0

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.2

—

10.5

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.0

—

(4027681)

0.00

0.0

1.4

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

3.9

—

179.1

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.02

0.00

2.0

1.7

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

3.2

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.4

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3038769) Chlamydophila pneumoniae IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

16.2

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

0.0

4.6

—

52.0

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

2.2

—

(3007461) Platelets [#/volume] in Blood

791

0.99

0.00

34.0

19.3

250.1

241.0

e9/l

0.59

772

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

7.0

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

(4268621)

0.00

0.0

2.4

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.8

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

0.0

3.5

—

(3000963) Hemoglobin [Mass/volume] in Blood

791

0.99

0.00

34.5

19.4

134.3

139.3

g/l

1.58

779

(3047826) Mullerian inhibiting substance [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

3.7

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

0.8

—

(3017315) Amylase [Enzymatic activity/volume] in Urine

0.00

0.0

1.3

—

353.8

—

(3002222) Hepatitis E virus IgM Ab [Presence] in Serum

0.00

0.0

1.0

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.4

—

6.0

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: ST19_TRAUMAT_AMPUT_ANKLE_FOOT – Traumatic amputation of ankle and foot

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Traumatic amputation of ankle and foot

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Traumatic amputation of ankle and foot (ST19_TRAUMAT_AMPUT_ANKLE_FOOT)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints