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This is a non-core endpoint: only basic statistics are computed.

See these related core endpoints for full statistics:

Left side

Z21_LEFT_SIDE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 ZB0.0
  • Cause of death: ICD-10 ZB0.0

2 out of 7 registries used, show all original rules.

143

4. Check minimum number of events

None

143

5. Include endpoints

None

143

6. Filter based on genotype QC (FinnGen only)

143

Control definitions (FinnGen only)

Control exclude
Z21_ADDIT_CODES_LOCAT_DEFECT_INJURY_ILLNE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Z[AB]

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 143 71 72
Unadjusted period prevalence (%) 0.03 0.02 0.03
Median age at first event (years) 69.23 70.69 67.79

-FinnGen-

Age distribution of first events

0102050607080051015202530354045AgeIndividuals

-FinnGen-

Year distribution of first events

1970197519801985199019952000200520102020202301020304050607080YearIndividuals

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
136
Matched controls
1358
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
ZB0.0
ICD-10 Finland
Left side
+∞
190.5
134
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
10.1
33.5
92
232
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
11.6
23.7
47
59
NF1BA
NOMESCO Finland
Hip extensive X-ray examination
22.2
23.3
34
20
SPAT1212
SPAT
Extensive examination of musculoskeletal system
10.5
22.4
47
65
M16.1
ICD-10 Finland
Other primary coxarthrosis
8.5
22.3
55
100
Z50.1
ICD-10 Finland
Other physical therapy
11.7
19.3
37
42
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
7.2
18.2
49
98
ZB0.1
ICD-10 Finland
Right side
+∞
18.1
17
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
7.3
14.6
37
66
B01AB05
ATC
enoxaparin; parenteral
3.6
11.2
70
308
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
4.0
9.7
43
140
R4135
NOMESCO Finland
Rehabilitation for hearing problems
15.1
9.4
15
11
Z25.8
ICD-10 Finland
Need for immunization against other specified single viral diseases
5.0
9.4
31
75
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
4.4
9.3
36
103
B01AB10
ATC
tinzaparin; parenteral
5.2
8.9
28
64
B01AF01
ATC
rivaroxaban; oral
3.9
8.8
39
126
M01AH05
ATC
etoricoxib; oral
3.0
8.1
98
630
N02BE01
ATC
paracetamol; systemic, rectal
8.5
7.9
132
1082
M16
ICD-10 Finland
Coxarthrosis [arthrosis of hip]
6.3
7.4
19
34
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
3.3
6.9
38
144

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
98
44
68.60
147.05
4.6
6.3
—
—
—
0
0
104
67
54.25
134.86
5.1
5.0
—
—
—
0
0
76
33
48.02
112.88
3.6
4.4
7.26
7.03
mmol/l
0.20
76
33
76
34
46.57
111.63
3.6
4.4
1.53
1.41
mmol/l
0.48
76
34
50
24
31.50
69.51
1.9
3.5
—
—
—
0
0
50
24
31.50
69.51
1.9
3.5
105.92
106.38
mmol/l
0.20
50
24
50
24
31.50
69.51
1.9
3.5
4.11
3.97
mmol/l
1.08
50
24
135
402
43.06
57.04
6.9
4.2
—
—
—
0
0
78
121
12.98
54.64
4.1
4.4
2.28
1.90
mmol/l
0.48
66
95
119
366
14.41
44.62
6.2
3.7
—
—
—
0
0
78
218
6.67
29.14
2.0
3.3
3.94
2.67
e6/l
0.40
78
117
130
590
14.24
28.76
7.6
4.8
—
—
—
0
0
108
421
7.40
27.56
5.7
3.4
—
—
—
0
0
27
31
10.50
22.29
5.2
5.4
30.33
27.66
mg/l
0.13
21
19
125
640
8.57
21.28
12.9
5.5
0.00
0.00
estimate
—
6
128
125
648
8.38
20.73
6.8
4.1
0.00
0.00
estimate
—
6
121
45
100
6.11
20.66
3.9
5.5
0.14
0.23
%
—
7
35
39
80
6.33
19.37
5.2
2.4
—
—
—
0
0
45
111
5.46
18.24
3.9
5.3
2.36
1.00
%
—
7
41
120
645
6.35
17.73
6.1
4.1
0.00
0.00
estimate
—
6
130
90
408
4.25
16.13
4.2
3.4
—
—
—
0
0
45
125
4.79
15.64
2.6
4.7
1.23
1.22
mmol/l
0.91
45
105
86
390
4.02
15.12
2.5
3.4
0.14
0.44
e6/l
2.46
86
288
69
271
3.99
14.94
6.2
6.0
—
—
—
0
0
75
318
3.86
14.40
1.4
1.4
—
—
—
0
0
86
411
3.74
13.55
2.1
2.8
—
—
—
0
0
52
178
4.02
13.51
3.5
7.1
105.73
103.22
mmol/l
3.85
52
173
95
546
3.20
10.00
4.3
4.1
31.49
40.83
ng/l
0.47
81
398
95
575
2.94
8.59
6.9
6.5
58.16
57.99
%
0.05
90
539
143
1260
+∞
7.28
25.1
15.5
—
—
—
0
0
57
288
2.63
7.00
1.9
1.8
1.05
1.43
mg/l
0.69
51
226
88
552
2.54
6.78
5.7
6.5
0.57
0.67
%
1.20
82
518
89
568
2.50
6.51
5.6
6.6
3.21
2.68
%
1.34
83
530
8
314
0.21
6.46
1.4
7.4
—
—
—
0
0
143
1278
+∞
6.45
20.7
18.8
140.40
139.63
mmol/l
4.15
143
1245
89
571
2.48
6.39
5.6
7.0
8.53
8.73
%
0.27
83
539
143
1283
+∞
6.24
20.5
18.9
4.04
3.99
mmol/l
1.78
143
1248
55
288
2.48
6.14
1.6
1.9
352.68
452.99
pmol/l
3.42
47
233
143
1295
+∞
5.63
25.2
19.5
79.63
80.35
umol/l
0.12
143
1295
85
562
2.26
5.33
4.3
4.7
36.53
35.10
g/l
1.63
85
526
114
871
2.52
4.85
6.2
4.5
—
—
—
0
0
22
82
2.99
4.67
2.7
2.6
—
—
—
0
0
82
556
2.11
4.57
12.3
9.1
1.20
1.25
inr
0.14
16
169
56
823
0.47
4.45
4.9
4.7
—
245.06
—
0
17
20
434
0.37
4.24
2.0
3.3
2.38
2.35
mmol/l
0.65
20
372
39
204
2.25
4.17
3.5
2.0
—
—
—
0
0
19
71
2.93
4.01
1.2
1.3
—
—
—
0
0
143
1334
+∞
3.84
31.9
23.9
4.46
4.48
e12/l
0.27
143
1292
143
1334
+∞
3.84
32.3
24.1
134.10
135.55
g/l
0.57
143
1312
143
1334
+∞
3.84
32.1
24.0
7.21
6.71
e9/l
1.10
143
1294
143
1334
+∞
3.84
31.9
23.8
90.62
91.42
fl
1.40
143
1314
143
1333
+∞
3.82
31.8
23.8
30.17
30.43
pg
1.06
143
1313
143
1333
+∞
3.82
31.9
23.9
263.36
244.71
e9/l
1.96
143
1299
28
509
0.44
3.77
3.0
2.1
—
—
—
0
0
0
82
0.00
3.26
0.0
1.2
—
—
—
0
0
29
151
2.15
3.08
2.7
1.7
—
—
—
0
0
6
184
0.30
2.95
1.0
1.3
—
—
—
0
0
5
7
7.35
2.57
1.2
2.0
—
—
—
0
0
27
148
2.02
2.50
4.2
4.6
2.63
38.26
ug/l
0.64
22
119
0
63
0.00
2.49
0.0
3.9
—
—
—
0
0
14
288
0.43
2.41
4.4
2.9
2.63
4.26
e6/l
1.27
14
256
0
60
0.00
2.31
0.0
3.9
—
24.47
—
0
54
6
14
4.42
2.17
1.2
1.4
—
—
—
0
0
34
221
1.71
1.85
1.6
1.3
48.56
38.54
iu/ml
—
9
73
23
368
0.55
1.84
5.4
3.3
—
—
—
0
0
17
296
0.52
1.79
6.4
3.9
—
—
—
0
0
0
48
0.00
1.73
0.0
3.3
—
—
—
0
0
0
48
0.00
1.73
0.0
1.3
—
—
—
0
0
8
166
0.45
1.60
1.9
1.3
—
—
—
0
0
66
519
1.50
1.60
2.0
2.0
86.73
95.74
pmol/l
1.05
42
255
5
127
0.37
1.59
1.6
2.4
0.24
0.22
g/l
—
5
117
0
45
0.00
1.53
0.0
1.4
—
—
—
0
0
5
18
2.84
1.29
1.2
1.2
—
—
—
0
0
30
208
1.56
1.27
1.4
1.3
1.89
11.03
u/ml
1.67
22
74
31
425
0.65
1.27
3.3
6.0
—
—
—
0
0
0
36
0.00
1.15
0.0
6.3
—
1.34
—
0
31
48
376
1.42
1.11
5.2
4.5
—
—
—
0
0
14
84
1.74
1.02
1.1
1.3
—
—
—
0
0
0
29
0.00
0.99
0.0
1.2
—
—
—
0
0
7
126
0.53
0.93
7.3
4.1
—
—
—
0
0
16
233
0.65
0.85
1.3
1.5
3.45
2.87
g/l
0.44
16
144
0
24
0.00
0.80
0.0
2.4
—
—
—
0
0
0
25
0.00
0.80
0.0
2.3
—
—
—
0
0
0
26
0.00
0.79
0.0
1.2
—
—
—
0
0
0
27
0.00
0.78
0.0
1.5
—
—
—
0
0
16
108
1.54
0.77
1.7
2.1
328.81
364.44
nmol/l
0.31
16
95
5
28
1.81
0.67
3.4
3.2
—
—
—
0
0
6
102
0.57
0.65
7.0
3.1
175.67
214.78
ng/l
—
6
92
6
104
0.56
0.64
1.5
2.9
10.38
10.15
g/l
—
6
90
0
20
0.00
0.61
0.0
1.6
—
—
—
0
0
0
20
0.00
0.61
0.0
2.6
—
—
—
0
0
0
20
0.00
0.61
0.0
1.2
—
—
—
0
0
0
20
0.00
0.61
0.0
1.9
—
—
—
0
0
0
20
0.00
0.61
0.0
1.6
—
—
—
0
0
0
20
0.00
0.61
0.0
1.6
—
—
—
0
0
0
20
0.00
0.61
0.0
1.6
—
—
—
0
0
7
115
0.59
0.60
1.4
1.5
—
—
—
0
0
0
21
0.00
0.60
0.0
2.0
—
89.45
—
0
21
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
0
22
0.00
0.60
0.0
2.2
—
62.10
—
0
22
0
23
0.00
0.59
0.0
1.1
—
—
—
0
0
6
35
1.74
0.58
2.0
1.6
—
—
—
0
0
5
88
0.55
0.58
1.2
1.8
0.82
1.63
g/l
—
5
78
8
123
0.63
0.57
1.4
1.3
—
—
—
0
0
9
62
1.48
0.54
1.1
1.2
—
—
—
0
0
8
118
0.66
0.48
1.5
1.4
—
—
—
0
0
5
31
1.63
0.43
1.0
6.1
—
—
—
0
0
11
149
0.72
0.42
1.3
1.3
—
—
—
0
0
20
247
0.78
0.42
1.2
1.2
0.92
0.83
u/ml
—
10
67
5
33
1.53
0.42
5.2
3.8
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
271.40
—
0
10
0
15
0.00
0.41
0.0
2.3
—
—
—
0
0
0
16
0.00
0.41
0.0
3.6
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
2.8
—
—
—
0
0
0
16
0.00
0.41
0.0
2.8
—
32.50
—
0
16
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
0
17
0.00
0.41
0.0
4.6
—
—
—
0
0
0
17
0.00
0.41
0.0
1.2
—
36820.50
—
0
10
0
17
0.00
0.41
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
3.7
—
—
—
0
0
43
379
1.19
0.38
2.3
2.9
85445.54
5975.03
umol/l
2.14
37
316
14
178
0.76
0.37
7.4
6.5
1.06
1.02
mmol/l
0.18
14
165
8
103
0.76
0.22
1.0
2.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
14.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
70.72
—
0
5
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
39.14
—
0
7
0
12
0.00
0.21
0.0
2.0
—
10.91
—
0
12
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
244.37
—
0
8
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
2.1
—
617.00
—
0
6
0
14
0.00
0.20
0.0
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
2.0
—
0.82
—
0
5
15
174
0.85
0.19
1.4
1.4
—
—
—
0
0
6
76
0.78
0.16
1.0
1.3
—
31.70
—
0
5
42
396
1.09
0.13
2.3
3.4
106.24
65.59
mg/l
0.40
29
260
5
46
1.09
0.09
1.0
4.7
68.10
48.39
mg/l
—
5
37
5
46
1.09
0.09
1.0
4.7
43.54
33.62
mg/l
—
5
37
10
113
0.88
0.08
1.8
1.5
—
—
—
0
0
23
215
1.08
0.08
2.9
1.8
27.82
29.51
s
1.46
23
208
6
73
0.81
0.08
1.5
2.8
1.03
1.45
g/l
—
6
64
90
916
0.95
0.06
3.6
4.2
—
—
—
0
0
10
110
0.90
0.05
3.6
8.8
—
—
—
0
0
13
140
0.92
0.04
2.2
3.4
11.46
8.03
umol/l
0.34
13
128
12
111
1.09
0.04
3.1
3.9
99.00
82.21
ng/l
—
6
98
29
282
1.04
0.02
4.9
4.5
1.02
1.02
kg/l
0.24
19
39
12
126
0.95
0.00
1.5
2.8
69.33
66.28
g/l
0.82
12
119
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
1.19
—
0
6
0
8
0.00
0.00
0.0
2.9
—
4.24
—
0
8
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
151.40
—
0
5
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
32.43
—
0
7
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
3.0
—
8.49
—
0
8
0
7
0.00
0.00
0.0
5.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
54
0.92
0.00
1.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
22.45
—
0
6
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: Z21_LEFT_SIDE – Left side

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).