Benign neoplasm: Pineal gland

CD2_BENIGN_PINEAL

adenoma: The congenital absence of the thyroid gland.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D35.4& Hospital discharge: ICD-9 — 2274 Hospital discharge: ICD-8 — 2263 Cause of death: ICD-10 — D35.4& Cause of death: ICD-9 — 2274 Cause of death: ICD-8 — 2263 2 out of 7 registries used, show all original rules.	82
4. Check minimum number of events None	82
5. Include endpoints None	82
6. Filter based on genotype QC (FinnGen only)	82

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D35
Name in latin: Neoplasma benignum corporis pinealis

NAME	CD2_BENIGN_PINEAL
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D354
HD_ICD_9	2274
HD_ICD_8	2263
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D354
COD_ICD_9	2274
COD_ICD_8	2263
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Benign neoplasm: Pineal gland based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Benign neoplasm: Pineal gland

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	487	326	160
Only index persons	454	312	142
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	32.24	32.69	31.22
Only index persons	31.98	31.98	31.98

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	82	61	21
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	36.89	35.46	41.04

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
76: Matched controls
757

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D35.4

ICD-10 Finland

Benign neoplasm: Pineal gland

+∞

101.4

G93.0

ICD-10 Finland

Cerebral cysts

113.6

9.7

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

7.2

8.1

AAB00

NOMESCO Finland

Extirpation of intracranial lesion

50.4

7.9

R51.80

ICD-10 Finland

Headache

4.4

7.0

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3016018) Differential panel - Cerebral spinal fluid

12.79

3.82

1.0

1.6

—

(3044290) Cell count panel - Cerebral spinal fluid

7.25

3.77

1.0

1.4

—

(3014007) Fractional oxyhemoglobin in Arterial blood

6.69

3.59

7.1

8.6

91.7

94.7

—

(3023410) Appearance of Cerebral spinal fluid

10.65

3.55

1.0

1.3

—

(3013707) Erythrocyte sedimentation rate by Westergren method

488

2.81

3.50

3.4

3.6

7.7

8.7

mm/h

0.41

452

(3035637) Corticotropin [Mass/volume] in Plasma

7.98

3.11

1.0

1.9

—

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

10.52

3.02

1.8

2.2

14.0

24.9

nmol/l

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

136

2.34

2.94

1.9

1.8

0.6

0.7

mg/l

0.03

102

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

4.99

2.66

1.4

1.1

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

4.99

2.66

7.7

7.4

0.9

0.8

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

4.99

2.66

7.9

7.4

2.1

1.2

—

(3032080) INR in Blood by Coagulation assay

185

2.09

2.50

3.5

5.4

1.0

1.1

inr

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

635

2.69

2.17

5.3

4.6

1.6

1.7

mu/l

0.42

595

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

5.24

2.10

1.0

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

525

2.15

2.09

4.7

4.1

14.6

14.4

pmol/l

0.26

486

(3013512) EKG study

136

1.96

1.84

3.1

2.9

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

188

1.84

1.76

3.7

2.6

11.5

14.0

ng/l

0.57

(3018405) Lactate [Moles/volume] in Arterial blood

4.02

1.74

11.0

2.8

1.4

1.6

mmol/l

—

(3003396) Base excess in Arterial blood by calculation

2.53

1.51

8.9

5.2

1.5

1.6

mmol/l

—

(3020891) Body temperature

3.06

1.38

10.8

2.6

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

636

2.08

1.35

11.8

8.4

92.5

95.7

ml/min/173m2

0.55

512

(3019060) Gas panel - Arterial blood

2.61

1.33

10.7

3.6

—

(3000991) Gas panel - Venous blood

2.61

1.33

2.3

6.0

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

159

1.72

1.32

1.8

1.9

—

(4034850)

2.89

1.30

4.4

14.8

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

204

1.65

1.28

3.4

2.7

—

(3009542) Hematocrit [Volume Fraction] of Blood

673

2.02

1.18

11.4

11.3

39.0

40.2

0.48

567

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.59

1.17

1.8

5.1

134.0

133.0

g/l

—

(3045414) Leukocytes [Presence] in Urine

2.47

1.10

2.0

1.3

—

(3002256) Pathology report gross observation

1.87

1.10

1.2

1.1

—

(3022621) pH of Urine by Test strip

2.12

1.09

3.1

2.0

—

(3044889) 12 lead EKG panel

402

1.54

1.08

2.8

—

(3019225) pH of Specimen

2.03

1.06

2.2

5.3

—

(3022948) Iron [Moles/volume] in Serum or Plasma

1.87

1.03

1.7

2.3

15.8

14.0

umol/l

0.53

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.03

0.99

1.7

—

(3012544) pH of Venous blood

2.03

0.99

1.9

4.3

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

171

1.57

0.98

3.5

3.8

2.4

mmol/l

0.88

154

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

469

1.52

0.97

7.4

7.1

73.4

73.6

u/l

0.02

438

(4035726)

1.97

0.96

1.0

1.5

—

(3007164) IgA [Mass/volume] in Serum or Plasma

163

1.57

0.96

1.2

1.4

2.3

2.2

g/l

0.12

102

(3024354) Oxygen [Partial pressure] in Venous blood

2.15

0.91

1.8

2.9

4.0

4.5

kpa

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

202

1.50

0.88

1.4

1.6

109.6

95.9

pmol/l

0.44

111

(3023368) Bacteria identified in Blood by Culture

118

1.56

0.77

4.2

3.8

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

619

1.58

0.77

3.7

3.4

5.6

5.7

mmol/l

0.36

579

(3021601) Nitrite [Presence] in Urine by Test strip

331

1.41

0.76

6.1

4.3

0.0

estimate

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.06

0.74

1.2

1.8

—

(40768804) Tissue Pathology biopsy report

266

1.40

0.72

1.8

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.50

0.72

1.8

1.5

—

(40761535) Cells panel - Urine sediment

1.73

0.70

2.6

2.9

—

(3019832) Treponema pallidum Ab [Presence] in Serum

196

0.66

0.68

1.4

1.8

—

(3018095) Leukocytes [#/volume] in Urine

231

1.40

0.67

4.2

2.8

151.3

33.4

e6/l

0.50

153

(3009261) Glucose [Presence] in Urine by Test strip

337

1.36

0.66

5.2

3.2

0.0

estimate

—

(3048689) Calprotectin [Mass/mass] in Stool

114

1.50

0.65

3.3

2.2

134.6

79.3

ug/g

0.36

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

1.53

0.64

1.1

1.6

452.1

490.1

pmol/l

0.15

(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.61

0.0

1.1

—

1.5

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.59

0.0

1.1

—

2.8

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.59

0.0

1.0

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

0.00

0.59

0.0

2.7

—

3.8

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

135

1.43

0.57

1.6

1.9

2.2

2.8

mg/l

0.98

116

(3021447) Carbon dioxide [Partial pressure] in Venous blood

1.67

0.57

2.0

4.1

5.8

5.7

kpa

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.56

0.57

3.8

2.7

29.4

25.5

u/l

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.48

0.54

7.1

5.7

—

(3044640) Blood type and Crossmatch panel - Blood

211

1.34

0.53

1.9

2.0

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.57

0.50

1.0

1.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

213

1.32

0.49

2.3

2.2

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

112

1.42

0.49

1.5

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

123

1.37

0.45

1.8

2.0

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.65

0.44

1.6

1.4

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

392

1.26

0.43

6.9

9.9

4.2

3.9

e9/l

0.52

349

(40761536) Microorganisms panel - Urine sediment

1.39

0.42

9.3

3.2

—

(3003694) ABO and Rh group [Type] in Blood

264

0.77

0.42

1.6

1.7

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.41

0.0

1.3

—

(4268621)

0.00

0.41

0.0

2.1

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

0.41

0.0

1.1

—

95.9

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.41

0.40

2.3

1.8

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.40

0.0

1.1

—

(3028707) Methadone [Presence] in Urine by Screen method

1.46

0.40

1.6

1.8

—

(36304419) Bacteria [Presence] in Urine

172

1.30

0.39

3.5

2.3

—

(42870588) Differential panel, method unspecified - Blood

202

1.27

0.37

6.9

6.5

—

(36660697) Celiac disease serology panel - Serum

1.42

0.36

1.1

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

193

1.27

0.36

2.1

2.0

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

101

1.34

0.34

2.9

2.2

—

(3018418) pH of Serum or Plasma

157

1.27

0.33

3.8

2.9

7.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

186

1.25

0.32

1.9

1.3

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

1.38

0.32

2.3

1.9

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

149

1.27

0.31

5.1

3.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.30

0.31

1.6

1.4

—

(3029937) Albumin [Presence] in Urine by Test strip

178

1.24

0.30

7.0

3.4

0.0

estimate

—

(3016879) Cocaine [Presence] in Urine

1.28

0.28

1.5

—

(3026008) Bacteria identified in Urine by Culture

180

1.22

0.27

4.4

2.4

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

1.30

0.27

3.6

2.5

3.7

6.6

umol/l

—

(40768797) Stomach Pathology biopsy report

1.24

0.26

1.1

1.3

—

(3023511) Choriogonadotropin [Units/volume] in Urine

1.30

0.23

1.6

1.4

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.27

0.23

1.2

1.5

—

(40766183) Gliadin peptide IgA Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

1.5

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

223

1.17

0.21

1.2

1.8

—

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

1.0

—

40.4

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.21

0.0

1.2

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

1.0

—

0.0

—

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

1.0

—

10.8

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

1.0

—

0.0

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

1.2

—

0.0

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.20

0.0

2.2

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.20

0.0

1.1

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.20

0.0

1.1

—

2.5

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.20

0.0

1.0

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.20

0.0

1.0

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.22

0.20

2.8

1.8

—

(3035350) Ketones [Presence] in Urine by Test strip

333

1.14

0.19

5.3

3.1

0.0

estimate

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

333

1.14

0.19

3.7

4.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.25

0.19

1.9

1.5

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.23

0.19

1.6

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

129

1.20

0.18

1.1

1.6

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

187

1.17

0.18

1.0

1.3

0.6

1.2

u/ml

—

(3028300) Cannabinoids [Presence] in Urine

1.21

0.17

1.6

1.5

—

(3000764) Benzodiazepines [Presence] in Urine

1.21

0.17

1.6

1.5

—

(3027008) Opiates [Presence] in Urine

1.21

0.17

1.6

1.5

—

(3027944) Amphetamines [Presence] in Urine

1.20

0.17

1.8

1.5

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.16

0.17

1.1

1.3

—

(3002385) Erythrocyte distribution width [Ratio]

598

1.15

0.16

15.6

13.0

13.3

13.4

0.54

592

(3042936) Bacteria identified in Isolate by Culture

1.12

0.15

1.4

2.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

259

1.12

0.14

5.5

3.1

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

649

0.87

0.14

4.1

3.3

1.6

1.5

mmol/l

0.83

613

(3012516) Albumin [Mass/volume] in Urine

124

1.16

0.12

8.1

3.1

110.4

65.0

mg/l

—

(1761868) Lipid panel - Serum or Plasma

259

0.90

0.12

2.6

2.1

—

(40758558) Short blood count panel - Blood

163

1.13

0.12

7.9

7.3

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

125

0.86

0.11

1.6

1.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.07

0.09

3.4

3.0

—

(3011288) Drugs identified in Urine by Screen method

1.07

0.09

1.4

1.9

—

(3017732) Neutrophils [#/volume] in Blood

1.12

0.09

4.5

2.8

4.2

3.8

e9/l

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

215

1.10

0.09

2.4

1.7

—

(3022145) Colonoscopy Study observation

0.81

0.08

1.6

1.4

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.82

0.08

1.6

1.4

—

(3000494) Fungus identified in Specimen by Culture

1.08

0.08

1.4

1.3

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

1.03

0.08

1.4

1.5

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

1.03

0.08

1.4

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

1.03

0.08

1.4

1.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.09

0.08

1.0

1.6

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

1.07

0.08

1.5

1.6

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

657

1.11

0.07

4.2

3.6

2.9

2.8

mmol/l

0.17

621

(3050129) First trimester maternal screen panel - Serum or Plasma

0.86

0.07

1.3

1.4

—

(3021589) Normoblasts [#/volume] in Blood

304

0.93

0.07

13.9

7.5

0.0

e9/l

0.50

250

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

102

0.87

0.07

2.0

1.8

—

(21494755) Public health laboratory ask at order entry panel

104

0.85

0.07

1.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

168

1.09

0.06

4.8

5.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

198

1.08

0.06

4.5

2.7

—

(3015736) pH of Urine

262

0.93

0.05

5.0

2.8

—

(3037467) Urinalysis macro (dipstick) panel - Urine

478

1.06

0.05

5.9

4.0

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

120

0.90

0.05

1.3

1.2

2.2

6.0

u/ml

—

(3020682) Albumin/Creatinine [Ratio] in Urine

130

1.09

0.05

9.5

3.7

34.1

7.8

mg/mmol

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

273

1.04

0.01

1.5

2.1

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

607

1.02

0.00

4.2

3.9

—

(3031040) Bacteria [#/volume] in Urine by Automated count

455

0.98

0.00

6.9

3.8

—

38.0

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

655

0.96

0.00

4.1

3.3

4.9

4.7

mmol/l

1.12

619

(3005033) Fetal Nuchal fold Thickness US

1.00

0.00

1.5

1.4

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.89

0.00

1.0

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.98

0.00

1.2

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.87

0.00

1.5

—

(3023659) Complement C1 esterase inhibitor.functional/Complement C1 esterase inhibitor.total in Serum or Plasma

0.00

0.0

1.0

—

102.8

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.2

—

5.4

—

(3002222) Hepatitis E virus IgM Ab [Presence] in Serum

0.00

0.0

1.0

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

3.5

—

91.2

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

106.9

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.5

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

0.3

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.4

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

3.6

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.97

0.00

1.7

1.5

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3029023) Hepatitis E virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

0.0

2.6

—

56.0

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

3.2

—

118.4

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3026179) Normetanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

0.4

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

3.6

—

106.1

—

(4062490)

0.00

0.0

1.4

—

(3030558) Cytomegalovirus DNA [Units/volume] (viral load) in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.0

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

3.6

—

4.0

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.0

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.4

—

5.3

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.2

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

3.1

—

(3034426) Prothrombin time (PT)

0.00

0.0

1.2

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

0.0

1.4

—

(3010503) CD19 cells [#/volume] in Blood

0.00

0.0

1.0

—

0.2

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

0.0

1.0

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.0

—

126.4

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

1.6

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.8

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.4

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.5

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

2.6

—

818.4

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.7

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.5

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

1.0

—

13.3

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.2

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.4

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.0

1.1

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_PINEAL and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_PINEAL.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_PINEAL – Benign neoplasm: Pineal gland

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Benign neoplasm: Pineal gland

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints