This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Hyposplenism
D3_HYPOSPLENISM
splenic disease: A disease involving the spleen.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
54 |
4. Check minimum number of eventsNone |
54 |
5. Include endpointsNone |
54 |
6. Filter based on genotype QC (FinnGen only) |
49 |
Control definitions (FinnGen only)
- Control exclude
- D3_BLOODOTHER
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D73
- Name in latin
- Hyposplenismus
Similar endpoints
↥List of similar endpoints to
Hyposplenism
based on the number of shared cases.
Similar with more cases:
- Diseases of spleen
- Other diseases of blood and blood-forming organs, wide
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 277 | 148 | 127 |
| Only index persons | 251 | 138 | 113 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.01 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 52.16 | 52.98 | 51.62 |
| Only index persons | 52.71 | 52.98 | 52.39 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 49 | 30 | 19 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 61.13 | 56.63 | 68.23 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 54
- Matched controls
- 540
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D73.0
ICD-10 Finland
Hyposplenism
+∞
77.3
54
*
JMA10
NOMESCO Finland
Transabdominal total splenectomy
241.7
17.6
17
*
XW000
NOMESCO Finland
Bone marrow biopsy
40.6
15.6
19
7
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
9.7
15.1
24
41
WX408
NOMESCO Finland
General anesthesy, balanced
8.7
14.8
32
77
WW200
NOMESCO Finland
Immunization
40.2
14.0
17
6
WW500
NOMESCO Finland
Blood transfusion
26.7
12.6
17
9
XF400
NOMESCO Finland
ECG with 12 standard connections
7.8
12.5
25
54
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
+∞
11.9
11
*
Z2221
NOMESCO Finland
Medical doctor
7.0
11.5
34
106
R4110
NOMESCO Finland
Physiotherapy
6.7
11.3
32
96
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
18.4
11.1
17
13
ZXD10
NOMESCO Finland
Scheduled procedure
7.2
11.0
39
143
ZXE10
NOMESCO Finland
More than one and less than three hours
6.0
9.7
34
120
ZX120
NOMESCO Finland
Intravenous
11.1
9.3
18
23
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
33.7
8.9
11
*
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
105.9
8.7
9
*
ZXE00
NOMESCO Finland
One hour or less
5.7
8.5
38
159
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
5.5
8.0
21
56
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
92.2
7.6
8
*
TPH04
NOMESCO Finland
Cathetrisation of vein
5.0
7.5
23
70
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
+∞
7.5
7
*
ZXE20
NOMESCO Finland
More than three and less than five hours
5.7
7.4
17
40
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.7
7.3
30
114
Z3226
NOMESCO Finland
Physiotherapist
4.9
7.0
21
62
Z3231
NOMESCO Finland
Registered nurse
4.5
7.0
28
104
R50.9
ICD-10 Finland
Fever, unspecified
5.0
7.0
20
57
JN4BD
NOMESCO Finland
Extensive body CT
7.2
6.9
17
32
R4190
NOMESCO Finland
Nutritional therapy
15.0
6.4
10
8
D75.9
ICD-10 Finland
Disease of blood and blood-forming organs, unspecified
+∞
6.4
6
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
7.8
6.2
14
23
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
22
13
27.45
16.05
3.6
2.2
95.45
90.08
%
0.26
22
13
27
52
9.38
15.33
9.3
8.2
1.11
1.02
mmol/l
0.72
27
47
20
12
25.51
14.39
3.8
2.3
3.28
4.33
g/l
0.92
20
12
35
108
7.37
12.15
5.0
2.7
0.56
0.39
e6/l
0.28
29
78
25
63
6.53
10.47
4.3
2.3
1.50
0.86
e6/l
0.44
12
31
23
55
6.54
10.13
4.7
4.1
0.81
0.82
mmol/l
0.07
23
50
30
96
5.78
9.53
5.3
1.8
1.49
1.06
mg/l
0.59
25
79
36
139
5.77
9.07
4.8
2.9
—
—
—
0
0
20
49
5.89
8.42
16.4
7.9
103.95
103.33
mmol/l
0.17
20
49
29
99
5.17
8.32
2.3
1.9
3.52
2.74
mg/l
0.59
23
86
23
65
5.42
8.24
4.6
2.3
2.09
0.60
e6/l
0.61
11
32
17
25
9.39
8.11
12.8
5.4
24.00
25.08
mmol/l
0.85
17
25
46
252
6.55
7.43
36.8
8.7
4.58
4.19
e9/l
0.42
46
218
11
9
14.93
6.94
1.6
2.7
—
—
—
0
0
30
118
4.47
6.92
5.4
3.2
283.68
7937.34
umol/l
1.07
25
102
37
172
4.66
6.77
2.4
1.9
96.52
92.09
pmol/l
0.22
22
90
9
5
21.13
6.51
1.7
1.2
—
—
—
0
0
28
110
4.21
6.36
12.1
2.2
—
—
—
0
0
12
16
9.29
6.02
2.6
1.1
0.00
0.00
g/l
-0.00
12
16
14
26
6.88
5.71
16.5
13.8
10.69
10.24
mmol/l
0.07
14
26
11
15
8.89
5.46
2.7
1.1
0.00
0.00
g/l
-0.00
11
15
11
15
8.89
5.46
2.7
1.1
0.00
0.00
g/l
-0.00
11
15
12
19
7.78
5.45
2.6
1.1
—
—
—
0
0
21
76
3.89
5.19
1.9
1.5
663.06
1139.84
nmol/l
3.32
16
60
12
23
6.39
4.80
7.7
11.3
92.00
94.43
%
0.44
12
23
36
193
3.60
4.78
14.2
2.6
336.31
87.10
ug/l
0.89
36
175
37
204
3.58
4.65
10.8
2.8
—
—
—
0
0
7
6
13.13
4.41
2.4
4.0
5.94
3.13
u/ml
—
7
6
16
53
3.87
4.40
2.3
1.3
—
—
—
0
0
10
18
6.55
4.21
1.3
1.4
—
—
—
0
0
11
24
5.47
4.01
11.9
5.1
24.45
25.23
mmol/l
0.17
11
24
16
57
3.57
3.93
2.3
1.4
—
—
—
0
0
13
35
4.56
3.93
11.1
2.9
5.38
5.03
kpa
0.15
13
35
7
9
8.72
3.68
1.6
1.2
—
—
—
0
0
6
6
11.03
3.59
1.0
1.2
—
—
—
0
0
6
6
11.03
3.59
1.2
1.0
102.17
111.33
%
—
6
6
12
33
4.37
3.57
7.7
23.3
106.58
127.45
g/l
1.87
12
33
6
7
9.44
3.35
1.0
1.0
—
—
—
0
0
7
11
7.12
3.30
1.3
1.0
—
—
—
0
0
7
11
7.12
3.30
1.7
1.5
—
—
—
0
0
7
11
7.12
3.30
1.3
1.0
—
—
—
0
0
8
17
5.32
3.05
1.8
1.2
—
—
—
0
0
9
24
4.28
2.82
2.6
1.6
—
—
—
0
0
5
6
9.01
2.80
1.6
1.8
—
—
—
0
0
5
6
9.01
2.80
2.0
1.3
—
—
—
0
0
5
6
9.01
2.80
1.0
1.0
94.80
102.67
%
—
5
6
5
8
6.74
2.42
2.0
1.3
—
—
—
0
0
49
400
3.42
2.34
4.0
4.1
1.27
1.28
mmol/l
0.03
44
365
40
287
2.52
2.30
5.6
3.1
53.69
47.13
u/l
0.24
35
269
12
49
2.86
2.29
7.9
16.6
-1.20
1.35
mmol/l
0.84
12
35
17
84
2.49
2.27
2.6
1.5
—
—
—
0
0
8
25
3.57
2.19
2.3
1.2
—
—
—
0
0
5
10
5.38
2.12
2.0
1.4
—
—
—
0
0
5
10
5.38
2.12
1.0
1.2
—
—
—
0
0
5
10
5.38
2.12
1.0
1.2
—
—
—
0
0
22
128
2.21
2.01
4.5
3.3
20.39
15.49
mg/mmol
0.13
15
83
5
11
4.88
1.98
2.0
1.4
—
—
—
0
0
49
408
3.17
1.98
47.9
12.4
85.18
83.86
ml/min/173m2
0.11
44
326
6
18
3.61
1.80
1.2
1.3
—
—
—
0
0
5
13
4.12
1.75
2.0
2.4
—
—
—
0
0
20
120
2.06
1.64
5.8
2.7
71.85
51.84
u/l
1.35
20
106
0
45
0.00
1.59
0.0
1.9
—
—
—
0
0
6
21
3.08
1.55
9.3
2.9
0.92
1.27
%
—
6
21
8
40
2.17
1.18
4.4
2.8
—
—
—
0
0
19
132
1.68
0.93
1.4
2.1
134.47
202.81
u/l
0.57
19
122
47
415
2.02
0.92
5.1
4.5
5.85
5.90
mmol/l
0.08
42
375
10
67
1.60
0.54
1.1
1.5
—
—
—
0
0
47
438
1.56
0.45
54.3
13.3
28.48
24.72
mg/l
0.37
41
328
13
100
1.40
0.38
1.5
1.6
—
—
—
0
0
34
314
1.22
0.23
4.1
3.2
—
—
—
0
0
0
11
0.00
0.21
0.0
2.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
41
390
1.21
0.17
8.0
5.2
40.17
39.54
mmol/mol
0.11
35
367
14
150
0.91
0.05
2.2
3.5
—
—
—
0
0
11
103
1.09
0.02
3.7
4.3
30.20
23.46
%
—
5
50
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
5
59
0.83
0.00
1.2
2.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
67
0.88
-0.00
1.5
2.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
7.68
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
12.84
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_HYPOSPLENISM and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have D3_HYPOSPLENISM.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: D3_HYPOSPLENISM – Hyposplenism
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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