splenic disease: A disease involving the spleen.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
586 |
4. Check minimum number of eventsNone |
586 |
5. Include endpoints |
605 |
6. Filter based on genotype QC (FinnGen only) |
605 |
Control definitions (FinnGen only)
- Control exclude
- D3_BLOODOTHER
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D70-D77
- Name in latin
- Morbi lienis
Similar endpoints
↥List of similar endpoints to
Diseases of spleen
based on the number of shared cases.
Similar with more cases:
- Other diseases of blood and blood-forming organs, wide
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4031 | 1960 | 2041 |
| Only index persons | 3439 | 1713 | 1726 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.06 |
| Only index persons | 0.06 | 0.06 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 59.75 | 60.79 | 58.66 |
| Only index persons | 58.74 | 59.31 | 58.18 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 605 | 307 | 298 |
| Unadjusted period prevalence (%) | 0.12 | 0.10 | 0.13 |
| Median age at first event (years) | 61.12 | 58.24 | 64.09 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 547
- Matched controls
- 5469
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D73.5
ICD-10 Finland
Infarction of spleen
+∞
191.2
172
*
D73.1
ICD-10 Finland
Hypersplenism
+∞
140.9
129
*
D73.9
ICD-10 Finland
Disease of spleen, unspecified
+∞
81.3
76
*
XW000
NOMESCO Finland
Bone marrow biopsy
15.9
67.5
114
89
D73.4
ICD-10 Finland
Cyst of spleen
+∞
62.7
59
*
JMA10
NOMESCO Finland
Transabdominal total splenectomy
84.3
60.6
67
9
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.2
56.2
173
377
D73.8
ICD-10 Finland
Other diseases of spleen
+∞
51.9
49
*
D73.0
ICD-10 Finland
Hyposplenism
+∞
47.6
45
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
10.6
41.1
83
91
R16.1
ICD-10 Finland
Splenomegaly, not elsewhere classified
209.4
38.3
39
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
4.8
35.0
130
332
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.4
34.4
114
256
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.2
33.9
241
1068
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
346.9
33.3
33
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.8
32.9
121
304
WW500
NOMESCO Finland
Blood transfusion
9.2
30.8
66
80
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.8
29.3
307
1709
D64.9
ICD-10 Finland
Anaemia, unspecified
4.7
29.0
108
272
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
17.4
28.6
45
28
D70.89
ICD-10 Finland
Neutropenic splenomegaly
+∞
28.4
27
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.7
25.4
249
1295
J01MA12
ATC
levofloxacin; systemic
3.3
24.9
151
574
JN4BD
NOMESCO Finland
Extensive body CT
3.9
23.8
106
314
C03CA01
ATC
furosemide; systemic
2.7
23.6
212
1034
D73.3
ICD-10 Finland
Abscess of spleen
+∞
23.1
22
*
N28.0
ICD-10 Finland
Ischaemia and infarction of kidney
125.2
22.8
24
*
M04AA01
ATC
allopurinol; systemic
3.5
22.6
121
415
R50.9
ICD-10 Finland
Fever, unspecified
3.3
20.8
119
427
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
18.2
20.2
31
18
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
20.1
162
728
R10.1
ICD-10 Finland
Pain localized to upper abdomen
3.1
20.0
129
502
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.0
19.2
129
515
L01XX05
ATC
hydroxycarbamide; oral
16.6
19.0
30
19
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
18.4
18.4
28
16
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
54.4
18.1
21
*
A02BC02
ATC
pantoprazole; systemic
2.3
18.0
380
2729
WW200
NOMESCO Finland
Immunization
7.3
17.8
43
63
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
15.2
17.8
29
20
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.5
17.5
164
792
JN3AD
NOMESCO Finland
Abdominal CT examination
3.8
16.4
73
213
B01AB05
ATC
enoxaparin; parenteral
2.3
16.3
200
1104
ZX120
NOMESCO Finland
Intravenous
3.4
16.1
83
273
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
7.2
15.7
38
56
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.0
15.7
65
178
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
87.6
15.6
17
*
TPH07
NOMESCO Finland
Cathetrisation of artery
3.1
15.2
90
327
UJF32
NOMESCO Finland
Coloscopy
2.3
15.2
169
884
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
5.3
15.2
47
96
D73.2
ICD-10 Finland
Chronic congestive splenomegaly
+∞
14.6
14
*
JN4AD
NOMESCO Finland
Body CT examination
3.5
14.5
70
218
D47.1
ICD-10 Finland
Chronic myeloproliferative disease
28.0
14.4
19
7
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.5
14.3
129
602
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.2
14.0
194
1113
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.3
13.8
151
777
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
13.7
175
966
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
21.8
13.4
19
9
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
11.3
13.1
24
22
N02AA05
ATC
oxycodone; systemic
2.6
12.9
101
434
D75.2
ICD-10 Finland
Essential thrombocytosis
71.5
12.6
14
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.5
12.6
107
481
AA1AD
NOMESCO Finland
CT of head and brain
2.2
12.5
148
782
D45
ICD-10 Finland
Polycythaemia vera
9.6
12.1
24
26
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.2
12.1
64
215
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
4.1
12.0
47
123
H02AB06
ATC
prednisolone; systemic
1.9
11.9
269
1837
I50.9
ICD-10 Finland
Heart failure, unspecified
2.6
11.9
93
400
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.4
11.7
58
185
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.6
11.7
88
369
ZXD05
NOMESCO Finland
Urgent procedure
2.0
11.7
190
1145
D75.9
ICD-10 Finland
Disease of blood and blood-forming organs, unspecified
66.4
11.6
13
*
C03DA01
ATC
spironolactone; oral
2.7
11.4
83
340
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
3.1
11.3
64
225
B01AB10
ATC
tinzaparin; parenteral
3.5
11.3
54
168
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
17.5
11.3
17
10
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.6
11.2
50
147
K86.3
ICD-10 Finland
Pseudocyst of pancreas
20.5
11.2
16
8
WX892
NOMESCO Finland
Monitored bed care
2.9
11.0
67
247
Z2221
NOMESCO Finland
Medical doctor
2.0
10.9
170
1005
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
5.8
10.6
29
52
C07AB07
ATC
bisoprolol; oral
1.8
10.5
271
1911
S36.0
ICD-10 Finland
Injury of spleen
112.0
10.5
11
*
B99
ICPC
Blood/lymph/spleen disease other
33.2
10.4
13
*
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
7.7
10.3
23
31
ZXE00
NOMESCO Finland
One hour or less
1.8
10.1
224
1494
N02AX02
ATC
tramadol; systemic, rectal
1.8
10.0
241
1656
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
3.3
9.9
49
157
JAH00
NOMESCO Finland
Laparotomy
5.1
9.9
30
61
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.4
9.8
48
152
SPAT1255
SPAT
Intravenous administration of medicine
3.3
9.8
49
158
A10AE04
ATC
insulin glargine; parenteral
2.7
9.8
71
291
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
5.4
9.7
28
54
A41.9
ICD-10 Finland
Sepsis, unspecified
4.4
9.7
34
81
L03AA13
ATC
pegfilgrastim; parenteral
5.0
9.6
30
63
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
5.3
9.5
28
55
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.8
9.5
60
227
B01AA03
ATC
warfarin; systemic
2.1
9.5
126
693
R06.0
ICD-10 Finland
Dyspnoea
2.0
9.4
141
812
9689/3-C42.2
ICD-O-3
Splenic marginal zone B-cell lymphoma of spleen
+∞
9.4
9
*
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
22.1
9.4
13
6
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
5.0
9.3
29
61
Z3231
NOMESCO Finland
Registered nurse
1.9
9.3
165
1014
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.1
9.2
108
564
XF400
NOMESCO Finland
ECG with 12 standard connections
2.2
9.2
103
526
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.0
9.1
125
698
D70.82
ICD-10 Finland
Drug-induced neutropenia
37.3
9.0
11
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.6
9.0
67
279
R4110
NOMESCO Finland
Physiotherapy
1.9
8.9
158
967
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
8.2
8.9
19
24
J01MA02
ATC
ciprofloxacin; systemic
1.8
8.9
221
1511
R58
ICD-10 Finland
Haemorrhage, not elsewhere classified
8.8
8.9
18
21
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
6.1
8.8
23
39
J01DB01
ATC
cefalexin; oral
1.9
8.8
441
3751
JAH01
NOMESCO Finland
Laparoscopy
4.3
8.7
31
75
A46
ICD-10 Finland
Erysipelas
2.2
8.7
92
459
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
10.3
8.6
16
16
ZXE10
NOMESCO Finland
More than one and less than three hours
1.8
8.5
200
1343
127
Kela drug reimbursment
Transplant complication
7.5
8.5
19
26
XW4XT
NOMESCO Finland
Biopsy of other inner organ with radiological guidance guidance
20.4
8.5
12
6
TGC00
NOMESCO Finland
Bronchial lavation
5.0
8.5
26
54
R04.0
ICD-10 Finland
Epistaxis
2.9
8.5
50
182
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
6.4
8.4
21
34
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
7.2
8.3
19
27
D47.3
ICD-10 Finland
Essential (haemorrhagic) thrombocythaemia
14.8
8.2
13
9
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.5
8.2
67
291
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
5.5
8.2
23
43
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.7
8.1
265
1955
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
6.0
8.1
21
36
C85.1
ICD-10 Finland
B-cell lymphoma, unspecified
22.4
8.0
11
5
R11
ICD-10 Finland
Nausea and vomiting
2.7
7.9
53
208
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.4
7.9
37
115
ZXE20
NOMESCO Finland
More than three and less than five hours
2.1
7.8
88
450
K86.08
ICD-10 Finland
Alcohol-induced chronic pancreatitis
15.3
7.7
12
8
WX402
NOMESCO Finland
General anaesthesia
2.1
7.6
92
483
N18.8
ICD-10 Finland
Other chronic renal failure
4.5
7.5
25
57
A05AA02
ATC
ursodeoxycholic acid; oral
7.3
7.5
17
24
C83.3
ICD-10 Finland
Diffuse large B-cell lymphoma
81.1
7.4
8
*
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
13.6
7.4
12
9
C91.0
ICD-10 Finland
Acute lymphoblastic leukaemia [ALL]
+∞
7.3
7
*
R53
ICD-10 Finland
Malaise and fatigue
1.9
7.3
114
664
P01AB01
ATC
metronidazole; oral, rectal
1.7
7.3
206
1447
A06AD11
ATC
lactulose; oral
2.1
7.3
84
431
1XC02
NOMESCO Finland
NA
16.0
7.3
11
7
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.1
7.2
26
65
ZX108
NOMESCO Finland
Inhalation
20.3
7.2
10
5
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
5.7
7.1
19
34
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
3.1
7.1
37
125
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
10.2
7.1
13
13
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.9
7.0
110
639
UJK02
NOMESCO Finland
ERCP
4.6
7.0
23
52
A02BC05
ATC
esomeprazole; systemic
1.7
7.0
216
1549
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.7
7.0
180
1224
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.7
7.0
45
174
N02BE01
ATC
paracetamol; systemic, rectal
1.8
6.9
456
4007
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
7.7
6.9
15
20
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.2
6.9
34
110
A03FA01
ATC
metoclopramide; systemic, rectal
1.9
6.9
109
637
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.0
6.9
93
513
TK800
NOMESCO Finland
Hemodialysis
4.6
6.8
22
49
JN1BD
NOMESCO Finland
Extensive CT examination of upper part of abdomen
9.5
6.8
13
14
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.9
6.8
39
139
JA3BT
NOMESCO Finland
Cathetrisation of abdominal cavity with X-ray guidance
40.6
6.8
8
*
120
Kela drug reimbursment
Hypogammaglobulinaemia
40.6
6.8
8
*
K76.6
ICD-10 Finland
Portal hypertension
40.6
6.8
8
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.2
6.8
71
353
JLC10
NOMESCO Finland
Distal pancreatectomy
16.9
6.8
10
6
I81
ICD-10 Finland
Portal vein thrombosis
16.9
6.8
10
6
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
16.9
6.8
10
6
D46.7
ICD-10 Finland
Other myelodysplastic syndromes
22.8
6.7
9
*
JKA20
NOMESCO Finland
Cholecystectomy
4.0
6.7
25
65
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.1
6.7
80
420
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.4
6.6
55
243
WX302
NOMESCO Finland
Thoracal epidural anesthesy
2.9
6.6
38
136
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.1
6.6
72
364
3AC01
NOMESCO Finland
NA
8.8
6.6
13
15
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
3.8
6.6
26
71
H02AB04
ATC
methylprednisolone; systemic
2.0
6.6
81
428
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
3.3
6.5
31
98
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
3.6
6.5
27
77
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
3.6
6.5
27
77
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
70.6
6.4
7
*
ZYB02
NOMESCO Finland
Outreach service at unit of another specialty
70.6
6.4
7
*
9950/3-C42.1
ICD-O-3
Polycythemia vera of bone marrow
14.5
6.4
10
7
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
14.5
6.4
10
7
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
6.4
121
748
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.4
6.4
29
89
K86.1
ICD-10 Finland
Other chronic pancreatitis
6.7
6.4
15
23
K85.9
ICD-10 Finland
Acute pancreatitis, unspecified
5.3
6.4
18
35
I82.9
ICD-10 Finland
Embolism and thrombosis of unspecified vein
5.6
6.3
17
31
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.9
6.3
106
628
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
3.5
6.3
28
84
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.1
6.3
33
112
D47.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue, unspecified
18.3
6.3
9
5
JM1AT
NOMESCO Finland
Cytology of spleen with ultrasound guidance
+∞
6.3
6
*
B25.8
ICD-10 Finland
Other cytomegaloviral diseases
27.0
6.2
8
*
B28
ICPC
Limited function/disability (B)
27.0
6.2
8
*
C83.1
ICD-10 Finland
Mantle cell lymphoma
27.0
6.2
8
*
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
5.1
6.2
18
36
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
3.1
6.1
31
103
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.1
6.1
72
374
WX002
NOMESCO Finland
Sedation and analgesia
1.8
6.1
109
662
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.9
6.1
94
543
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.7
6.0
39
151
Mortality – FinRegistry
↥Association
Association between endpoint D3_SPLEENDISEASE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_SPLEENDISEASE | 3.971 [3.07, 5.14] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.19 |
During the follow-up period (1.1.1998 — 31.12.2019), 415 out of 1386 females with D3_SPLEENDISEASE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_SPLEENDISEASE | 3.698 [2.92, 4.68] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 499 out of 1462 males with D3_SPLEENDISEASE died.
Mortality risk
Mortality risk for people of age
years, who have D3_SPLEENDISEASE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.481% | 0.759% |
| 5 | 2.249% | 4.089% |
| 10 | 5.579% | 10.28% |
| 15 | 10.302% | 19.424% |
| 20 | 17.274% | 31.076% |
Relationships between endpoints
↥Index endpoint: D3_SPLEENDISEASE – Diseases of spleen
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data