hypersplenism: Overactive functioning of the spleen, resulting in excessive destruction of blood cells.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
159 |
4. Check minimum number of eventsNone |
159 |
5. Include endpointsNone |
159 |
6. Filter based on genotype QC (FinnGen only) |
155 |
Control definitions (FinnGen only)
- Control exclude
- D3_BLOODOTHER
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D73
- Name in latin
- Hypersplenismus
Similar endpoints
↥List of similar endpoints to
Hypersplenism
based on the number of shared cases.
Similar with more cases:
- Diseases of spleen
- Other diseases of blood and blood-forming organs, wide
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1082 | 469 | 602 |
| Only index persons | 882 | 381 | 501 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.02 |
| Only index persons | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 58.66 | 59.57 | 57.67 |
| Only index persons | 56.73 | 57.62 | 56.06 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 155 | 71 | 84 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.04 |
| Median age at first event (years) | 58.01 | 56.66 | 59.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 159
- Matched controls
- 1590
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D73.1
ICD-10 Finland
Hypersplenism
+∞
221.1
156
*
XW000
NOMESCO Finland
Bone marrow biopsy
37.0
82.7
56
23
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
10.5
46.8
70
111
D64.9
ICD-10 Finland
Anaemia, unspecified
8.7
33.3
52
84
R16.1
ICD-10 Finland
Splenomegaly, not elsewhere classified
384.4
32.1
31
*
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
74.1
31.6
35
6
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
6.2
29.8
91
282
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
11.3
26.2
30
32
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
7.4
24.9
43
76
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.9
20.7
45
99
C03CA01
ATC
furosemide; systemic
4.5
19.8
77
273
J01MA12
ATC
levofloxacin; systemic
4.9
19.7
59
171
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
44.4
19.1
23
6
R50.9
ICD-10 Finland
Fever, unspecified
4.9
18.9
54
150
JMA10
NOMESCO Finland
Transabdominal total splenectomy
107.2
18.0
19
*
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
71.4
17.1
19
*
C03DA01
ATC
spironolactone; oral
5.2
16.9
42
103
D70.89
ICD-10 Finland
Neutropenic splenomegaly
189.0
16.8
17
*
JN4BD
NOMESCO Finland
Extensive body CT
5.2
16.6
41
100
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
7.0
16.2
27
45
WW500
NOMESCO Finland
Blood transfusion
14.5
15.5
26
21
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
+∞
14.8
14
*
ZX120
NOMESCO Finland
Intravenous
5.1
14.2
34
80
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.6
14.0
100
507
TPH04
NOMESCO Finland
Cathetrisation of vein
3.7
12.8
56
206
JN4AD
NOMESCO Finland
Body CT examination
4.8
12.7
33
83
JN3BD
NOMESCO Finland
Extensive abdominal CT
4.8
12.7
33
83
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
6.2
12.5
23
42
M04AA01
ATC
allopurinol; systemic
4.0
11.6
39
119
D47.1
ICD-10 Finland
Chronic myeloproliferative disease
129.0
11.6
12
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.7
11.4
23
46
WW200
NOMESCO Finland
Immunization
15.4
11.3
18
13
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
46.9
11.1
13
*
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
30.5
10.9
14
5
TPH07
NOMESCO Finland
Cathetrisation of artery
4.4
10.8
30
79
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.6
10.7
43
148
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.2
10.6
56
229
A05AA02
ATC
ursodeoxycholic acid; oral
25.4
10.4
14
6
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
3.8
9.6
34
107
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
+∞
9.5
9
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
5.5
9.4
19
38
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.8
9.2
75
384
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
53.0
8.8
10
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
17.5
8.7
13
8
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
4.9
8.6
20
45
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
94.9
8.5
9
*
9689/3-C42.2
ICD-O-3
Splenic marginal zone B-cell lymphoma of spleen
+∞
8.4
8
*
R18
ICD-10 Finland
Ascites
15.6
8.4
13
9
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
23.5
8.1
11
5
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
11.7
8.0
14
13
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
16.1
7.8
12
8
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
47.3
7.8
9
*
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
12.7
7.7
13
11
127
Kela drug reimbursment
Transplant complication
19.5
7.7
11
6
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.6
7.7
28
89
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
26.5
7.7
10
*
L04AD02
ATC
tacrolimus; systemic
83.8
7.5
8
*
XW4XT
NOMESCO Finland
Biopsy of other inner organ with radiological guidance guidance
83.8
7.5
8
*
I81
ICD-10 Finland
Portal vein thrombosis
83.8
7.5
8
*
UJF30
NOMESCO Finland
Ileoscopy through colon
3.8
7.5
25
75
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
10.1
7.5
14
15
JN3AD
NOMESCO Finland
Abdominal CT examination
3.4
7.4
29
97
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
16.7
7.3
11
7
A46
ICD-10 Finland
Erysipelas
3.0
7.3
37
145
UJF32
NOMESCO Finland
Coloscopy
2.6
7.2
53
253
C07AB07
ATC
bisoprolol; oral
2.5
7.2
88
533
L01XX05
ATC
hydroxycarbamide; oral
14.6
7.0
11
8
Z01.8
ICD-10 Finland
Other specified special examinations
2.7
6.9
46
208
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
7.0
6.8
16
25
120
Kela drug reimbursment
Hypogammaglobulinaemia
41.9
6.8
8
*
K92.1
ICD-10 Finland
Melaena
5.8
6.7
18
34
JN6AD
NOMESCO Finland
CT of torso and neck
13.0
6.7
11
9
A10AE04
ATC
insulin glargine; parenteral
3.3
6.5
27
93
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
72.6
6.5
7
*
L01EJ01
ATC
ruxolitinib; oral
72.6
6.5
7
*
C07AG02
ATC
carvedilol; oral
4.3
6.3
17
43
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
27.9
6.3
8
*
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
+∞
6.3
6
*
A07AA11
ATC
rifaximin; oral
+∞
6.3
6
*
D70.82
ICD-10 Finland
Drug-induced neutropenia
+∞
6.3
6
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.1
6.3
18
48
H02AB06
ATC
prednisolone; systemic
2.3
6.3
86
537
L04AD01
ATC
ciclosporin; systemic
13.2
6.2
10
8
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
7.8
6.1
13
18
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
6.9
6.0
14
22
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
82
132
11.76
55.15
4.7
2.4
2.15
1.67
%
2.45
75
118
63
95
10.33
43.60
4.3
2.5
0.19
0.22
g/l
1.58
57
88
36
27
16.94
39.57
1.8
2.2
—
—
—
0
0
67
150
6.99
31.41
4.1
2.3
22.29
24.57
%
0.44
55
130
33
32
12.75
30.85
2.2
3.6
63.28
239.46
mg/l
0.43
27
26
33
32
12.75
30.85
2.2
3.6
27.91
29.42
mg/l
0.08
28
26
68
158
6.77
30.60
3.9
2.2
2.32
2.36
g/l
0.18
63
142
31
28
13.51
30.29
3.8
2.1
2.29
4.28
g/l
5.12
31
28
39
54
9.24
28.08
2.4
1.8
0.79
1.46
g/l
4.35
28
45
35
43
10.15
27.63
1.6
1.3
—
—
—
0
0
68
175
6.04
27.03
4.0
2.2
11.50
14.14
umol/l
1.70
63
159
132
603
8.00
26.94
19.2
5.9
26.58
27.57
%
0.40
126
574
128
596
6.89
24.68
17.3
5.7
58.40
57.69
%
0.24
121
568
80
255
5.30
24.45
3.2
1.9
3.51
3.07
mg/l
0.70
68
223
57
148
5.44
21.91
8.3
2.7
10.25
4.90
umol/l
2.32
50
126
31
16
23.72
21.87
3.5
4.6
940.00
4817.40
u/ml
—
5
5
136
744
6.72
19.58
22.3
8.8
4.30
4.18
e9/l
0.07
124
644
60
187
4.55
18.05
3.3
2.0
—
—
—
0
0
105
494
4.31
17.75
5.1
2.5
412.03
120.73
ug/l
0.98
100
459
113
582
4.25
16.29
13.7
6.8
1.19
1.21
mmol/l
1.97
98
507
58
191
4.21
15.98
2.1
1.7
1260.41
1229.50
nmol/l
0.08
47
155
26
21
14.55
15.54
1.7
1.2
—
—
—
0
0
108
551
3.99
15.51
25.1
12.8
1.40
1.21
inr
1.08
36
154
44
128
4.37
14.15
2.4
1.8
—
—
—
0
0
34
81
5.07
13.98
3.2
1.6
—
—
—
0
0
18
7
28.71
13.70
3.5
2.0
1439.28
710.29
u/ml
—
18
7
23
20
13.23
13.32
1.5
1.2
—
—
—
0
0
22
18
13.98
13.08
1.6
1.2
283.64
192.90
u/ml
—
11
10
43
132
4.09
12.77
2.5
1.9
—
—
—
0
0
83
397
3.28
12.36
5.3
2.7
57.99
65.27
u/l
0.23
77
371
75
339
3.29
12.26
5.0
2.5
349.20
6149.63
umol/l
1.52
70
300
21
36
6.57
12.14
2.2
1.5
1.08
1.15
g/l
0.43
21
36
17
9
20.94
11.88
2.4
2.0
—
—
—
0
0
22
41
6.07
11.72
2.2
3.3
—
—
—
0
0
29
74
4.57
10.86
5.7
3.4
1.46
1.49
mmol/l
0.02
19
53
87
459
2.98
10.44
2.7
1.8
100.33
96.06
pmol/l
0.26
50
235
17
13
14.47
10.43
1.1
1.2
—
—
—
0
0
62
287
2.90
9.24
6.2
2.2
—
—
—
0
0
19
39
5.40
9.10
2.7
2.9
—
—
—
0
0
21
32
7.39
9.02
3.3
1.9
—
—
—
0
0
81
441
2.71
8.72
5.0
3.0
—
—
—
0
0
18
37
5.36
8.59
1.3
1.3
—
—
—
0
0
98
590
2.72
8.58
6.5
2.6
—
—
—
0
0
18
26
7.66
8.04
2.9
1.6
—
—
—
0
0
34
120
3.33
7.98
6.6
3.4
1.90
1.91
mmol/l
0.00
29
92
19
31
6.81
7.83
3.7
1.8
—
—
—
0
0
19
31
6.81
7.83
2.0
1.1
—
—
—
0
0
56
265
2.72
7.81
2.9
1.6
1.69
1.00
mg/l
0.87
44
205
13
11
12.74
7.73
4.6
1.4
33.46
34.18
pg
0.21
13
11
18
28
7.11
7.67
4.1
2.0
175.56
200.14
%
0.37
18
28
16
21
8.34
7.60
3.5
1.9
—
—
—
0
0
12
9
14.29
7.51
1.6
1.2
—
—
—
0
0
11
7
16.74
7.34
1.6
1.1
3.16
4.91
mg/l
—
11
7
12
10
12.86
7.21
1.1
1.0
—
—
—
0
0
66
352
2.50
7.09
4.9
2.9
0.26
0.48
e6/l
1.04
51
261
15
20
8.16
7.08
1.8
1.8
—
—
—
0
0
16
24
7.28
7.02
3.4
2.0
—
—
—
0
0
16
24
7.28
7.02
3.4
2.0
—
—
—
0
0
11
8
14.65
7.00
1.1
1.3
—
—
—
0
0
10
6
17.65
6.84
1.1
1.0
—
—
—
0
0
14
18
8.41
6.77
1.8
1.6
—
—
—
0
0
15
22
7.41
6.70
6.3
3.6
60.20
60.14
%
0.00
15
22
16
28
6.23
6.34
2.1
1.8
—
—
—
0
0
11
11
10.64
6.13
2.0
1.6
—
—
—
0
0
14
22
6.87
6.01
5.3
2.9
3.87
4.62
e9/l
0.27
14
22
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
17
35
5.31
5.94
5.4
2.3
0.34
0.30
u/ml
—
10
20
15
27
6.02
5.85
1.1
1.3
—
—
—
0
0
11
13
8.99
5.66
1.4
1.2
—
—
—
0
0
8
5
16.73
5.47
1.1
3.0
—
—
—
0
0
8
5
16.73
5.47
1.1
3.0
—
—
—
0
0
22
75
3.24
5.39
1.3
1.4
—
—
—
0
0
9
8
11.83
5.36
2.2
1.9
24.00
11.00
u/l
—
9
8
13
23
6.05
5.19
2.2
1.9
—
—
—
0
0
13
23
6.05
5.19
2.2
1.9
—
—
—
0
0
8
6
13.94
5.13
2.5
1.3
—
—
—
0
0
8
6
13.94
5.13
2.5
1.3
—
—
—
0
0
35
162
2.49
4.90
3.2
2.0
1.62
1.51
%
0.41
28
145
16
47
3.67
4.89
4.6
2.2
—
—
—
0
0
8
7
11.94
4.84
4.9
2.4
—
—
—
0
0
8
7
11.94
4.84
4.9
2.4
—
—
—
0
0
50
274
2.20
4.75
1.3
1.3
0.98
0.85
u/ml
0.15
12
83
10
14
7.54
4.73
4.1
2.0
—
—
—
0
0
10
14
7.54
4.73
4.1
2.0
—
—
—
0
0
10
14
7.54
4.73
4.1
2.0
—
—
—
0
0
18
59
3.31
4.68
2.6
1.4
—
—
—
0
0
32
145
2.51
4.67
7.2
9.5
1.05
1.40
mmol/l
0.16
27
118
15
44
3.66
4.59
2.5
1.5
—
—
—
0
0
39
195
2.33
4.59
3.3
2.7
2.00
1.71
e6/l
0.11
17
109
10
15
7.03
4.54
1.0
1.8
—
—
—
0
0
19
66
3.13
4.51
7.6
5.1
24.96
24.66
mmol/l
0.11
19
66
33
156
2.41
4.39
9.2
5.7
103.36
104.00
mmol/l
0.29
33
156
8
9
9.28
4.33
2.1
1.8
—
—
—
0
0
8
9
9.28
4.33
2.8
1.8
—
—
—
0
0
7
6
12.12
4.31
2.7
1.3
—
—
—
0
0
7
6
12.12
4.31
2.3
1.8
—
—
—
0
0
7
6
12.12
4.31
5.7
1.3
—
—
—
0
0
7
6
12.12
4.31
2.7
1.3
—
—
—
0
0
7
6
12.12
4.31
2.3
1.8
—
—
—
0
0
10
17
6.20
4.20
4.5
1.9
—
—
—
0
0
10
18
5.85
4.04
4.5
1.8
—
—
—
0
0
12
27
4.72
4.03
1.7
1.4
—
—
—
0
0
12
27
4.72
4.03
1.7
1.4
—
—
—
0
0
10
19
5.54
3.89
1.1
1.2
—
—
—
0
0
7
8
9.08
3.81
2.4
1.6
—
—
—
0
0
19
73
2.82
3.80
4.2
2.5
2.12
1.46
%
0.56
19
73
6
6
10.32
3.52
5.8
2.3
—
—
—
0
0
6
6
10.32
3.52
5.8
2.3
—
—
—
0
0
6
6
10.32
3.52
5.8
2.3
—
—
—
0
0
14
47
3.17
3.51
3.1
1.9
—
—
—
0
0
10
22
4.78
3.49
4.4
3.2
15.24
15.65
%
—
5
12
25
117
2.35
3.38
8.0
11.1
111.84
122.56
g/l
1.56
25
117
62
408
1.85
3.37
4.6
3.3
2.31
2.36
mmol/l
2.22
57
360
11
28
4.14
3.36
4.2
1.4
—
—
—
0
0
11
28
4.14
3.36
1.2
1.3
—
—
—
0
0
27
132
2.26
3.31
2.6
5.1
2.27
37.80
ug/l
0.61
22
114
38
214
2.02
3.26
3.2
2.5
0.69
0.96
e6/l
0.59
18
127
24
113
2.32
3.20
5.2
3.4
—
—
—
0
0
115
924
1.88
3.16
4.4
3.7
14.53
14.83
pmol/l
0.79
106
846
69
480
1.77
3.06
7.1
3.7
26.99
37.14
ng/l
0.58
56
326
5
5
10.26
3.00
1.0
1.0
—
—
—
0
0
8
17
4.89
2.96
1.9
1.8
—
—
—
0
0
8
17
4.89
2.96
1.9
1.8
—
—
—
0
0
6
9
6.87
2.89
1.0
1.2
—
—
—
0
0
8
18
4.62
2.83
5.0
1.4
—
—
—
0
0
8
18
4.62
2.83
5.0
1.4
—
—
—
0
0
84
628
1.72
2.83
5.3
3.2
0.00
0.00
estimate
-0.00
24
135
7
14
5.18
2.76
1.1
1.1
—
—
—
0
0
6
10
6.18
2.72
1.2
1.3
—
—
—
0
0
6
10
6.18
2.72
1.0
1.0
—
—
—
0
0
6
10
6.18
2.72
1.0
1.1
—
—
—
0
0
8
19
4.37
2.71
5.0
1.4
—
—
—
0
0
8
19
4.37
2.71
5.0
1.4
—
—
—
0
0
8
19
4.37
2.71
5.0
1.4
—
—
—
0
0
8
19
4.37
2.71
5.0
1.4
—
—
—
0
0
16
69
2.47
2.58
4.1
2.5
0.66
0.66
%
0.01
16
69
6
11
5.62
2.56
1.0
1.1
—
—
—
0
0
35
209
1.87
2.51
1.3
1.3
46.05
5.31
u/ml
—
8
83
54
371
1.69
2.40
5.1
4.0
34.94
12.87
mg/mmol
0.69
37
253
52
354
1.70
2.39
3.4
2.0
93.08
247.99
u/l
2.16
52
335
37
229
1.80
2.36
1.5
1.2
141.64
37.28
iu/ml
0.54
14
73
36
221
1.81
2.36
5.1
3.6
637.52
251.35
ng/l
0.27
30
171
82
630
1.62
2.35
5.4
3.3
0.00
0.00
estimate
-0.00
22
118
9
28
3.34
2.34
2.4
1.4
—
—
—
0
0
6
13
4.75
2.29
1.2
1.2
—
—
—
0
0
6
13
4.75
2.29
1.2
1.2
—
—
—
0
0
6
13
4.75
2.29
1.2
1.2
—
—
—
0
0
6
13
4.75
2.29
1.2
1.2
—
—
—
0
0
6
13
4.75
2.29
1.2
1.2
—
—
—
0
0
9
29
3.23
2.26
1.6
1.2
—
—
—
0
0
81
625
1.60
2.25
6.7
4.5
0.00
0.00
estimate
-0.00
22
127
50
343
1.67
2.22
6.6
3.4
0.00
0.00
estimate
-0.00
20
121
20
103
2.08
2.17
2.6
3.0
44.30
68.88
ml/min/173m2
—
10
43
19
98
2.07
2.05
3.2
2.3
17.28
9.28
ug/l
0.36
13
88
144
1308
2.07
1.96
48.5
13.4
21.89
24.10
mg/l
0.47
137
1018
136
1220
1.79
1.83
39.1
12.3
80.48
83.20
ml/min/173m2
0.57
115
997
8
31
2.66
1.68
1.4
1.4
—
—
—
0
0
15
77
2.05
1.65
1.1
1.2
29.16
150.26
iu/ml
—
7
27
5
14
3.65
1.63
2.4
1.9
—
—
—
0
0
5
16
3.19
1.45
1.2
1.3
—
—
—
0
0
6
22
2.79
1.45
2.7
1.1
—
—
—
0
0
5
18
2.83
1.29
4.2
2.9
3.42
3.22
nmol/l
—
5
18
6
127
0.45
1.23
1.3
1.6
—
—
—
0
0
10
181
0.52
1.17
1.6
1.5
—
—
—
0
0
127
1159
1.48
1.15
5.5
4.3
2.15
1.93
mu/l
0.98
118
1069
61
504
1.34
0.98
6.0
3.3
—
—
—
0
0
7
36
1.99
0.98
1.1
1.1
—
—
—
0
0
124
1139
1.40
0.97
55.1
15.7
15.96
14.79
%
1.63
124
1127
7
41
1.74
0.71
1.6
1.4
—
—
—
0
0
7
42
1.70
0.69
1.7
1.2
—
—
—
0
0
7
42
1.70
0.69
1.7
1.2
—
—
—
0
0
5
29
1.75
0.64
1.6
1.1
0.93
0.89
nmol/l
—
5
23
121
1275
0.79
0.58
5.4
4.3
1.17
1.43
mmol/l
10.69
113
1187
125
1184
1.26
0.53
8.3
5.5
40.30
39.85
mmol/mol
0.15
113
1121
19
144
1.36
0.53
4.5
4.6
29.79
31.52
%
0.30
14
96
125
1305
0.80
0.48
5.6
4.8
2.31
2.77
mmol/l
7.11
119
1210
118
1234
0.83
0.42
5.6
3.8
1.44
1.31
mmol/l
1.13
109
1146
123
1281
0.82
0.41
5.4
4.3
4.07
4.65
mmol/l
8.74
116
1201
9
71
1.28
0.37
1.7
1.3
—
—
—
0
0
27
232
1.20
0.31
2.1
1.6
—
—
—
0
0
88
831
1.13
0.29
4.1
3.1
—
—
—
0
0
128
1241
1.16
0.27
6.2
4.3
6.45
5.94
mmol/l
2.15
120
1146
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
169.03
—
0
13
5
65
0.76
0.17
2.0
1.9
—
—
—
0
0
13
147
0.87
0.12
13.4
7.7
—
—
—
0
0
36
381
0.93
0.11
3.9
4.2
20.23
20.11
%
0.01
15
185
5
44
1.14
0.10
2.6
1.7
—
—
—
0
0
7
68
1.03
0.08
1.0
1.0
—
—
—
0
0
146
1450
1.08
0.04
71.0
19.3
37.55
40.81
%
6.05
140
1381
12
119
1.01
0.00
2.3
2.2
11.04
13.40
nmol/l
0.60
12
110
14
139
1.01
0.00
1.4
1.8
—
—
—
0
0
15
151
0.99
0.00
1.7
1.9
—
—
—
0
0
28
281
1.00
0.00
3.0
2.8
0.72
0.72
ug/l
0.01
20
184
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
26.72
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
5
56
0.89
-0.00
1.2
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
43.57
—
0
7
Mortality – FinRegistry
↥Association
Association between endpoint D3_HYPERSPLENISM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HYPERSPLENISM | 6.062 [3.72, 9.87] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.274 |
During the follow-up period (1.1.1998 — 31.12.2019), 136 out of 361 females with D3_HYPERSPLENISM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HYPERSPLENISM | 4.648 [3.31, 6.52] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 174 out of 469 males with D3_HYPERSPLENISM died.
Mortality risk
Mortality risk for people of age
years, who have D3_HYPERSPLENISM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.658% | 0.829% |
| 5 | 3.469% | 5.303% |
| 10 | 8.399% | 13.102% |
| 15 | 16.608% | 22.798% |
| 20 | 27.309% | 36.245% |
Relationships between endpoints
↥Index endpoint: D3_HYPERSPLENISM – Hypersplenism
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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