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Infarction of spleen

DOID EFO Endpoint Browser PheWeb

D3_INFARCTSPLEEN

splenic infarction: Insufficiency of arterial or venous blood supply to the spleen due to emboli, thrombi, vascular torsion, or pressure that produces a macroscopic area of necrosis. (From Stedman, 25th ed)

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D73.5
  • Hospital discharge: ICD-8 — 28942
  • Cause of death: ICD-10 — D73.5
  • Cause of death: ICD-8 — 28942

2 out of 7 registries used, show all original rules.

191

4. Check minimum number of events

None

191

5. Include endpoints

None

191

6. Filter based on genotype QC (FinnGen only)

191

Control definitions (FinnGen only)

Control exclude
D3_BLOODOTHER

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D73
Name in latin
Infarctus lienis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1148 520 622
Only index persons 1015 470 545
Unadjusted period prevalence (%)
Whole population 0.02 0.01 0.02
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 67.93 70.81 65.47
Only index persons 67.43 70.42 64.85

-FinnGen-

Key figures

All Female Male
Number of individuals 191 90 101
Unadjusted period prevalence (%) 0.04 0.03 0.04
Median age at first event (years) 68.97 68.81 69.10

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
173
Matched controls
1730
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D73.5
ICD-10 Finland
Infarction of spleen
+∞
247.0
172
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
8.1
24.4
61
109
N28.0
ICD-10 Finland
Ischaemia and infarction of kidney
250.3
22.1
22
*
L01XX05
ATC
hydroxycarbamide; oral
125.2
21.1
22
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
12.5
18.2
33
32
JN3AD
NOMESCO Finland
Abdominal CT examination
8.2
17.2
40
61
R10.1
ICD-10 Finland
Pain localized to upper abdomen
5.2
16.3
58
154
D45
ICD-10 Finland
Polycythaemia vera
93.8
15.9
17
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.4
14.8
48
114
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.1
14.5
50
127
B01AB05
ATC
enoxaparin; parenteral
3.6
14.2
91
405
C03CA01
ATC
furosemide; systemic
3.4
13.0
88
401
B01AA03
ATC
warfarin; systemic
3.7
12.8
69
262
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.3
12.0
86
403
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.0
11.9
53
170
D47.1
ICD-10 Finland
Chronic myeloproliferative disease
+∞
11.6
11
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.1
11.5
108
604
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.5
11.1
62
238
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.7
10.9
54
189
M04AA01
ATC
allopurinol; systemic
4.2
10.6
44
131
XW000
NOMESCO Finland
Bone marrow biopsy
7.2
10.0
24
38
TPH04
NOMESCO Finland
Cathetrisation of vein
3.3
9.8
59
237
D75.2
ICD-10 Finland
Essential thrombocytosis
+∞
9.5
9
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.6
9.3
33
84
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.9
9.2
73
350
TPH07
NOMESCO Finland
Cathetrisation of artery
4.0
9.1
38
113
WW500
NOMESCO Finland
Blood transfusion
7.9
9.0
20
28
WX892
NOMESCO Finland
Monitored bed care
4.8
9.0
30
72
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
5.1
8.9
28
63
D47.3
ICD-10 Finland
Essential (haemorrhagic) thrombocythaemia
52.7
8.8
10
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.7
8.8
25
50
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
15.5
8.3
13
9
N02AA05
ATC
oxycodone; systemic
3.2
8.2
46
174
B01AB10
ATC
tinzaparin; parenteral
4.4
8.1
29
75
C07AB07
ATC
bisoprolol; oral
2.5
7.9
105
660
I50.9
ICD-10 Finland
Heart failure, unspecified
3.2
7.9
46
177
A02BC05
ATC
esomeprazole; systemic
2.5
7.4
84
479
AA1AD
NOMESCO Finland
CT of head and brain
2.6
7.2
63
310
R11
ICD-10 Finland
Nausea and vomiting
4.3
7.2
26
68
JAH00
NOMESCO Finland
Laparotomy
8.9
7.0
14
17
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.8
6.9
48
207
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.6
6.8
57
273
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
17.6
6.8
10
6
A02BC02
ATC
pantoprazole; systemic
2.4
6.6
125
897
N02AX02
ATC
tramadol; systemic, rectal
2.3
6.6
89
543
R10.0
ICD-10 Finland
Acute abdomen
7.9
6.6
14
19
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
7.9
6.6
14
19
ECB00
NOMESCO Finland
Suture of gingiva
7.9
6.6
14
19
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
6.0
6.5
17
31
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
3.9
6.5
26
75
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
15.1
6.5
10
7
D70.89
ICD-10 Finland
Neutropenic splenomegaly
72.4
6.5
7
*
K86.3
ICD-10 Finland
Pseudocyst of pancreas
72.4
6.5
7
*
K55.0
ICD-10 Finland
Acute vascular disorders of intestine
72.4
6.5
7
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.9
6.3
40
163
JN4BD
NOMESCO Finland
Extensive body CT
3.2
6.3
34
122
9950/3-C42.1
ICD-O-3
Polycythemia vera of bone marrow
+∞
6.3
6
*
SPAT1074
SPAT
Venesection
+∞
6.3
6
*
I50.0
ICD-10 Finland
Congestive heart failure
4.0
6.2
24
67
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.8
6.2
25
73
H02AB06
ATC
prednisolone; systemic
2.2
6.1
95
612

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
132
452
7.22
39.53
10.0
4.2
—
—
—
0
0
23
15
17.30
26.68
1.7
1.3
—
—
—
0
0
27
24
12.94
26.37
1.4
1.2
3.9
6.3
u/ml
—
15
9
146
694
5.68
26.04
20.8
9.5
1.4
1.3
inr
0.78
40
211
74
218
4.91
24.16
6.2
5.2
1.1
1.0
mmol/l
0.66
67
201
26
25
11.88
24.10
1.3
1.0
73.0
13.1
u/l
1.28
19
20
120
517
4.55
23.56
6.5
2.4
57.2
57.0
u/l
0.01
115
480
102
400
4.33
22.56
3.3
2.0
4.4
3.3
mg/l
1.87
95
342
74
230
4.62
22.35
3.5
2.5
22.2
22.5
%
0.05
63
198
115
495
4.33
22.26
14.1
5.2
—
—
—
0
0
22
19
12.96
21.74
1.3
1.2
—
—
—
0
0
26
30
9.87
21.16
2.0
2.2
—
—
—
0
0
146
770
4.80
20.77
11.1
5.5
2.0
1.8
e9/l
1.07
136
682
147
790
4.74
20.10
12.7
6.6
1.2
1.2
mmol/l
0.16
132
663
156
882
5.19
19.77
19.1
8.8
5.5
4.2
e9/l
2.35
146
770
142
755
4.43
19.44
10.9
5.3
0.7
0.6
e9/l
1.99
132
652
142
758
4.40
19.26
11.0
5.4
0.1
0.0
e9/l
1.35
132
656
143
780
4.32
18.48
13.2
5.4
0.2
0.2
e9/l
0.02
133
690
19
17
12.30
18.27
1.6
1.1
—
—
—
0
0
109
500
3.75
18.21
6.3
2.4
—
—
—
0
0
47
118
4.96
18.20
7.8
4.6
0.5
0.3
%
0.51
22
32
37
77
5.72
17.69
2.0
1.8
1.3
1.6
g/l
0.79
32
65
50
135
4.66
17.68
8.2
4.4
1.0
1.0
%
0.03
28
50
54
157
4.40
17.34
4.3
2.7
84.6
65.9
e9/l
2.59
44
126
31
56
6.41
17.12
1.2
4.4
41.5
30.3
mg/l
0.56
25
45
31
56
6.41
17.12
1.2
4.4
50.8
180.2
mg/l
0.59
25
45
134
723
3.86
17.04
10.7
4.3
—
—
—
0
0
25
37
7.62
16.57
1.2
5.7
—
—
—
0
0
68
243
3.79
16.29
3.3
2.0
—
—
—
0
0
17
16
11.57
15.76
2.1
1.9
—
—
—
0
0
48
137
4.34
15.68
8.3
8.3
—
—
—
0
0
82
342
3.45
15.34
2.7
1.8
2.0
1.5
mg/l
0.62
69
277
93
421
3.36
15.19
5.2
3.0
371.6
7461.9
umol/l
1.96
84
355
42
113
4.48
14.75
1.3
2.5
—
—
—
0
0
44
125
4.27
14.38
8.7
4.5
0.2
0.2
%
0.01
25
43
62
225
3.60
14.29
9.2
6.6
103.7
103.7
mmol/l
0.03
62
219
20
27
8.16
14.26
1.4
1.2
—
—
—
0
0
79
335
3.32
14.20
3.7
3.0
517.9
554.6
mosm/kgh2o
0.94
73
285
103
512
3.20
14.11
4.8
3.3
21.2
181.4
e6/l
0.68
89
392
53
175
3.81
14.04
13.0
7.5
95.0
95.6
%
0.18
53
170
108
553
3.19
14.03
4.4
3.0
1511.2
1342.0
ng/l
0.29
100
458
14
12
12.51
13.68
1.1
1.0
—
—
—
0
0
47
146
3.94
13.55
2.6
2.6
7.5
8.0
ug/l
0.08
38
132
51
168
3.78
13.52
5.3
3.8
—
—
—
0
0
41
117
4.19
13.27
8.6
4.7
0.2
0.2
%
0.02
22
37
79
347
3.18
13.22
3.4
2.6
7.8
4.3
e6/l
0.78
73
307
110
586
3.07
13.04
5.7
3.8
153.8
68.1
e6/l
0.32
92
423
92
447
3.04
12.82
4.4
3.0
—
—
—
0
0
99
501
3.03
12.82
5.5
3.9
7.4
7.4
ph
0.19
18
110
95
473
3.01
12.62
4.6
3.1
0.4
0.5
e6/l
0.26
82
350
99
505
2.99
12.57
4.0
3.3
2.3
2.3
mmol/l
0.22
88
440
16
19
9.10
12.55
1.2
1.2
—
—
—
0
0
52
185
3.49
12.17
1.4
1.3
512.0
330.3
titre
—
10
39
47
158
3.62
11.99
5.3
3.7
2.5
2.0
mmol/l
0.46
36
126
53
193
3.42
11.95
13.0
6.9
5.0
5.1
kpa
0.29
53
185
49
170
3.53
11.91
1.5
1.5
—
—
—
0
0
53
194
3.40
11.84
13.1
6.9
1.9
1.0
mmol/l
0.88
43
157
70
306
3.03
11.57
6.3
3.6
476.8
162.1
ng/l
1.12
63
254
37
109
3.97
11.38
4.9
3.5
119.8
126.0
g/l
0.75
37
109
73
333
2.93
11.10
2.2
1.8
1206.2
1324.7
nmol/l
0.53
61
245
44
150
3.51
10.92
1.4
1.6
—
—
—
0
0
52
198
3.23
10.81
1.6
1.7
—
—
—
0
0
54
211
3.17
10.75
44.0
22.8
1.8
1.3
inr
—
5
30
36
111
3.76
10.34
12.1
4.0
—
—
—
0
0
78
388
2.71
9.86
17.0
6.7
—
—
—
0
0
19
37
5.59
9.58
1.6
1.3
0.2
0.2
g/l
0.34
19
37
31
91
3.87
9.52
19.3
8.1
—
—
—
0
0
34
108
3.61
9.32
14.6
6.2
23.8
24.4
mmol/l
0.22
34
100
47
186
3.03
9.03
2.1
1.7
—
—
—
0
0
32
100
3.64
8.97
1.4
1.4
—
—
—
0
0
151
1077
2.92
8.66
7.4
4.4
—
—
—
0
0
18
37
5.27
8.55
1.1
1.4
—
—
—
0
0
110
678
2.47
8.53
6.8
3.9
116.2
41.2
ng/l
0.54
93
513
158
1169
3.03
8.18
6.8
4.1
17.8
13.0
mm/h
2.93
151
1063
28
87
3.60
7.89
4.5
2.8
1.4
1.2
%
0.45
28
87
13
22
6.27
7.48
8.9
3.8
—
—
—
0
0
105
665
2.29
7.26
2.7
1.9
85.9
93.9
pmol/l
1.18
73
324
38
152
2.87
7.06
1.8
1.3
—
—
—
0
0
74
410
2.31
6.98
2.2
1.5
18.7
20.9
nmol/l
0.63
66
343
26
85
3.38
6.76
6.1
3.8
24.2
24.7
mmol/l
0.21
26
85
107
700
2.20
6.63
23.6
10.0
0.1
0.0
e9/l
0.65
96
575
64
341
2.32
6.55
9.1
5.3
—
—
—
0
0
82
486
2.20
6.48
4.2
3.2
—
—
—
0
0
16
39
4.39
6.22
1.3
1.3
—
—
—
0
0
68
388
2.17
5.79
1.4
1.3
—
—
—
0
0
25
89
3.08
5.66
1.3
1.3
—
—
—
0
0
115
806
2.07
5.60
8.4
5.2
0.0
0.0
estimate
0.00
30
166
116
820
2.06
5.46
6.2
3.9
0.0
0.0
estimate
0.00
31
158
8
5
16.60
5.46
1.0
1.0
—
—
—
0
0
114
804
2.04
5.37
6.2
3.8
0.0
0.0
estimate
0.00
29
168
12
27
4.68
5.11
1.1
1.1
—
—
—
0
0
179
1538
3.61
4.97
50.1
15.0
33.4
23.9
mg/l
4.43
174
1227
14
37
4.00
4.91
3.4
2.9
—
—
—
0
0
11
24
4.80
4.84
2.8
1.6
—
—
—
0
0
11
24
4.80
4.84
2.8
1.6
—
—
—
0
0
11
24
4.80
4.84
2.8
1.6
—
—
—
0
0
11
24
4.80
4.84
2.8
1.6
—
—
—
0
0
10
20
5.22
4.83
2.0
1.5
—
—
—
0
0
16
48
3.55
4.72
6.6
3.4
—
—
—
0
0
54
303
2.09
4.68
3.8
3.2
2.5
2.4
mmol/l
0.63
45
268
19
65
3.14
4.59
7.0
4.1
—
—
—
0
0
8
8
10.37
4.56
2.3
2.6
—
—
—
0
0
8
8
10.37
4.56
1.1
1.3
—
—
—
0
0
41
211
2.20
4.40
1.5
1.3
—
—
—
0
0
91
627
1.86
4.27
2.5
2.1
—
—
—
0
0
51
291
2.03
4.18
1.6
1.4
2.8
2.6
g/l
0.19
37
175
14
42
3.52
4.13
1.1
1.3
—
—
—
0
0
162
1362
2.25
4.02
51.2
15.6
37.3
39.9
%
2.39
93
925
38
201
2.11
3.79
1.4
1.3
—
—
—
0
0
8
12
6.90
3.71
2.3
1.2
594.6
705.1
e6/l
—
8
7
7
9
8.02
3.59
12.4
8.1
—
—
—
0
0
8
13
6.37
3.54
1.0
1.0
—
—
—
0
0
13
42
3.25
3.44
1.2
1.4
—
—
—
0
0
40
224
1.99
3.41
1.3
1.3
31.5
12.2
u/ml
0.55
15
93
7
10
7.22
3.39
1.3
2.2
12.3
13.0
umol/l
—
7
10
43
248
1.95
3.37
1.3
1.3
37.2
42.3
iu/ml
0.13
13
77
36
195
2.04
3.36
2.5
1.4
—
—
—
0
0
9
19
4.91
3.28
1.6
1.4
—
—
—
0
0
9
20
4.67
3.15
1.1
1.1
—
—
—
0
0
8
16
5.17
3.08
2.6
1.4
—
—
—
0
0
8
16
5.17
3.08
7.1
3.6
—
—
—
0
0
56
362
1.77
3.06
6.0
3.8
—
—
—
0
0
7
12
6.01
3.05
7.9
3.6
—
—
—
0
0
7
12
6.01
3.05
1.4
1.1
—
—
—
0
0
137
1132
1.74
2.98
6.7
4.1
—
—
—
0
0
67
459
1.71
2.97
6.8
4.2
0.0
0.0
estimate
0.00
26
162
9
22
4.24
2.92
4.4
2.0
32.7
33.7
pg
—
9
22
8
18
4.59
2.82
1.1
1.0
—
—
—
0
0
13
48
2.83
2.78
2.8
4.2
0.3
0.1
g/l
—
6
19
138
1153
1.71
2.77
4.9
3.7
15.2
15.0
pmol/l
0.47
131
1020
5
6
8.51
2.76
1.0
1.2
—
—
—
0
0
32
180
1.93
2.69
1.4
1.3
—
—
—
0
0
74
534
1.63
2.64
3.5
3.9
21.7
7.6
mg/mmol
0.64
57
337
8
20
4.13
2.60
1.1
1.1
—
—
—
0
0
55
370
1.68
2.56
1.8
1.8
475.0
448.6
pmol/l
0.27
49
294
28
156
1.93
2.42
1.7
2.2
473.2
109.1
ug/g
0.76
22
123
10
35
2.96
2.34
9.2
3.8
59.3
61.3
%
—
10
35
9
28
3.32
2.34
1.6
1.7
45.0
62.1
%
—
9
28
6
13
4.73
2.29
1.5
1.3
—
—
—
0
0
7
18
3.99
2.27
1.6
1.2
—
—
—
0
0
12
48
2.60
2.23
3.8
2.6
24.5
24.6
mmol/l
—
7
41
13
56
2.42
2.10
4.1
3.3
4.0
3.9
mmol/l
0.48
13
49
5
10
5.10
2.08
1.0
1.4
1.5
1.5
g/l
—
5
10
5
10
5.10
2.08
1.0
1.0
—
—
—
0
0
50
346
1.60
2.06
7.4
4.2
1.0
1.0
kg/l
—
9
37
8
26
3.17
2.04
1.5
1.5
36.1
16.5
ug/l
—
8
26
19
98
2.04
2.03
1.2
1.2
—
—
—
0
0
177
1637
2.11
1.98
45.8
13.9
—
—
—
0
0
62
455
1.54
1.97
5.9
3.7
—
—
—
0
0
67
505
1.50
1.87
6.1
4.1
—
—
—
0
0
7
23
3.12
1.81
1.1
1.1
—
—
—
0
0
68
517
1.49
1.81
3.0
3.0
6.9
7.4
mmol/l
0.47
58
417
66
499
1.49
1.81
3.1
3.1
935.5
51.8
mg/l
0.51
51
324
24
141
1.80
1.78
6.2
3.7
—
—
—
0
0
5
13
3.92
1.72
1.0
1.2
224.6
362.3
nmol/l
—
5
8
5
13
3.92
1.72
1.2
1.1
—
—
—
0
0
13
62
2.18
1.70
3.0
1.9
—
—
—
0
0
8
31
2.65
1.68
2.8
2.8
—
—
—
0
0
6
19
3.23
1.67
2.2
1.5
—
—
—
0
0
23
137
1.77
1.64
5.7
4.5
—
—
—
0
0
178
1667
2.00
1.63
54.1
17.9
87.3
80.6
umol/l
1.60
178
1667
5
14
3.64
1.62
2.2
1.2
—
—
—
0
0
5
14
3.64
1.62
1.2
1.6
6.1
12.1
%
—
5
14
6
20
3.06
1.59
1.0
1.4
—
—
—
0
0
168
1552
1.68
1.55
5.5
4.8
6.4
6.1
mmol/l
1.76
151
1398
19
109
1.83
1.53
2.3
2.5
5.1
3.9
e9/l
0.42
13
84
39
531
0.67
1.45
2.7
3.3
—
—
—
0
0
7
29
2.47
1.40
5.0
3.8
103.7
105.7
mmol/l
—
7
29
7
29
2.47
1.40
5.0
3.8
—
—
—
0
0
7
29
2.47
1.40
5.0
3.8
4.1
4.0
mmol/l
—
7
29
6
23
2.66
1.38
1.2
2.8
—
—
—
0
0
5
17
2.99
1.36
1.2
3.1
—
—
—
0
0
24
155
1.63
1.31
4.1
3.7
1.2
1.2
mmol/l
0.16
24
137
10
48
2.14
1.30
5.5
4.2
1.7
1.4
mmol/l
—
10
48
5
18
2.82
1.29
1.8
1.2
—
—
nmol/l
—
0
0
14
77
1.88
1.29
3.4
4.3
—
—
—
0
0
9
44
2.10
1.28
2.8
2.4
1.5
1.8
mg/l
—
9
38
9
45
2.05
1.25
6.0
4.3
7.2
7.6
mmol/l
—
9
45
14
78
1.86
1.25
1.1
1.5
—
—
—
0
0
161
1495
1.49
1.19
8.1
6.2
42.2
40.5
mmol/mol
0.92
150
1381
5
21
2.42
1.09
2.2
1.7
—
—
—
0
0
7
32
2.23
1.09
3.7
2.9
—
—
—
0
0
7
34
2.10
1.04
1.0
1.3
—
—
—
0
0
19
125
1.58
0.98
1.5
1.4
—
—
—
0
0
20
134
1.55
0.96
1.5
1.5
—
—
—
0
0
6
27
2.26
0.94
1.3
1.3
—
—
—
0
0
40
311
1.36
0.91
1.4
1.2
1.2
0.8
u/ml
—
8
93
22
153
1.49
0.90
6.9
3.8
—
—
—
0
0
179
1724
1.61
0.81
70.6
21.9
124.7
135.4
g/l
10.94
179
1696
8
47
1.73
0.81
1.0
1.6
—
—
—
0
0
12
75
1.64
0.77
1.8
2.8
—
—
—
0
0
0
20
0.00
0.60
0.0
1.4
—
—
—
0
0
156
1488
1.26
0.57
5.3
4.2
1.5
1.3
mmol/l
3.69
141
1349
6
38
1.60
0.55
5.2
3.1
—
—
—
0
0
8
56
1.45
0.43
5.9
5.9
—
—
—
0
0
10
70
1.45
0.42
1.4
1.2
—
—
—
0
0
10
70
1.45
0.42
1.2
1.2
82.3
230.0
u/ml
—
10
65
5
32
1.58
0.42
1.0
1.2
13.4
6.7
u/l
—
5
26
0
15
0.00
0.41
0.0
2.5
—
627.4
—
0
8
0
16
0.00
0.41
0.0
1.0
—
252.7
—
0
9
5
34
1.48
0.40
1.4
1.2
—
—
—
0
0
8
114
0.69
0.38
1.3
1.5
—
—
—
0
0
12
90
1.36
0.36
6.8
4.6
—
—
—
0
0
11
83
1.35
0.33
2.9
2.4
—
—
—
0
0
163
1590
1.17
0.28
6.2
5.3
2.3
2.7
mmol/l
7.45
150
1443
159
1549
1.16
0.28
5.7
4.7
4.0
4.5
mmol/l
9.31
147
1413
0
12
0.00
0.21
0.0
1.2
—
61.7
—
0
5
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
35
376
0.92
0.14
2.4
3.2
0.6
0.8
ug/l
1.10
21
262
8
95
0.84
0.14
1.4
1.2
—
—
—
0
0
156
1540
1.07
0.10
5.7
4.7
1.2
1.4
mmol/l
11.84
140
1400
5
48
1.04
0.09
1.0
1.1
—
—
—
0
0
64
660
0.95
0.08
5.0
5.1
4.2
2.9
ug/l
0.30
54
584
14
127
1.11
0.08
2.4
2.0
9.8
13.9
nmol/l
0.78
14
115
12
112
1.08
0.03
4.3
3.1
—
—
—
0
0
16
152
1.06
0.02
1.7
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
112.1
—
0
9
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
2.1
—
—
—
0
0
9
91
0.99
0.00
1.1
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
4.3
—
0
6
0
5
0.00
0.00
0.0
1.0
—
18.6
—
0
5
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint D3_INFARCTSPLEEN and mortality.

Females

Parameter HR [95% CI] p-value
D3_INFARCTSPLEEN 4.274 [2.49, 7.33] < 0.001
Birth year 0.995 [0.99, 1.0] 0.268

During the follow-up period (1.1.1998 — 31.12.2019), 141 out of 337 females with D3_INFARCTSPLEEN died.

Males

Parameter HR [95% CI] p-value
D3_INFARCTSPLEEN 3.945 [2.59, 6.01] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 157 out of 407 males with D3_INFARCTSPLEEN died.

Mortality risk

Mortality risk for people of age

years, who have D3_INFARCTSPLEEN.

N-year risk Females Males
1 0.375% 0.58%
5 2.654% 3.864%
10 6.187% 9.639%
15 12.077% 17.816%
20 20.399% 28.01%

Relationships between endpoints

↥

Index endpoint: D3_INFARCTSPLEEN – Infarction of spleen

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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