splenic infarction: Insufficiency of arterial or venous blood supply to the spleen due to emboli, thrombi, vascular torsion, or pressure that produces a macroscopic area of necrosis. (From Stedman, 25th ed)
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
224 |
4. Check minimum number of eventsNone |
224 |
5. Include endpointsNone |
224 |
6. Filter based on genotype QC (FinnGen only) |
217 |
Control definitions (FinnGen only)
- Control exclude
- D3_BLOODOTHER
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D73
- Name in latin
- Infarctus lienis
Similar endpoints
↥List of similar endpoints to
Infarction of spleen
based on the number of shared cases.
Similar with more cases:
- Diseases of spleen
- Other diseases of blood and blood-forming organs, wide
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1148 | 520 | 622 |
| Only index persons | 1015 | 470 | 545 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 67.93 | 70.81 | 65.47 |
| Only index persons | 67.43 | 70.42 | 64.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 217 | 101 | 116 |
| Unadjusted period prevalence (%) | 0.05 | 0.04 | 0.05 |
| Median age at first event (years) | 69.00 | 68.97 | 69.02 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 224
- Matched controls
- 2240
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D73.5
ICD-10 Finland
Infarction of spleen
+∞
321.1
223
*
JN3AD
NOMESCO Finland
Abdominal CT examination
8.2
47.6
81
144
JN3BD
NOMESCO Finland
Extensive abdominal CT
7.7
40.7
71
128
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
10.3
35.6
44
52
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.5
34.9
72
152
A49.9
ICD-10 Finland
Bacterial infection, unspecified
6.5
34.1
70
147
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
6.5
27.8
53
102
R10.1
ICD-10 Finland
Pain localized to upper abdomen
4.9
27.4
82
236
N28.0
ICD-10 Finland
Ischaemia and infarction of kidney
106.2
26.3
28
*
B01AB05
ATC
enoxaparin; parenteral
4.0
24.0
123
518
C03CA01
ATC
furosemide; systemic
4.0
23.5
121
509
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.8
21.5
120
525
B01AA03
ATC
warfarin; systemic
4.0
20.9
84
294
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.9
20.5
152
793
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.8
19.0
78
275
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
5.7
18.8
39
80
M04AA01
ATC
allopurinol; systemic
4.2
18.7
63
193
L01XX05
ATC
hydroxycarbamide; oral
24.3
18.7
26
12
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.6
18.2
82
306
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.8
18.1
73
253
XW000
NOMESCO Finland
Bone marrow biopsy
7.3
17.9
28
43
I50.9
ICD-10 Finland
Heart failure, unspecified
3.9
17.9
66
215
JN4AD
NOMESCO Finland
Body CT examination
4.6
17.7
49
129
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
6.0
17.6
34
65
N02AA05
ATC
oxycodone; systemic
3.5
16.9
79
300
WW500
NOMESCO Finland
Blood transfusion
6.8
16.8
28
46
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.3
16.4
93
397
B01AB10
ATC
tinzaparin; parenteral
4.4
16.2
47
128
TPH07
NOMESCO Finland
Cathetrisation of artery
4.2
16.1
50
143
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.2
15.8
99
447
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.2
14.8
45
126
TPH04
NOMESCO Finland
Cathetrisation of vein
3.2
14.4
79
327
AA1AD
NOMESCO Finland
CT of head and brain
2.9
13.7
96
455
D47.1
ICD-10 Finland
Chronic myeloproliferative disease
137.4
12.6
13
*
D45
ICD-10 Finland
Polycythaemia vera
19.4
12.3
18
10
WX892
NOMESCO Finland
Monitored bed care
4.2
12.2
36
98
I50.0
ICD-10 Finland
Congestive heart failure
4.1
11.9
36
100
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
12.1
11.3
20
18
WX402
NOMESCO Finland
General anaesthesia
2.9
10.9
65
277
A10AE04
ATC
insulin glargine; parenteral
3.4
10.1
41
139
C03DA01
ATC
spironolactone; oral
3.2
10.0
47
174
R10.0
ICD-10 Finland
Acute abdomen
10.3
10.0
19
20
D64.9
ICD-10 Finland
Anaemia, unspecified
3.3
9.9
41
141
H02AB06
ATC
prednisolone; systemic
2.5
9.8
130
806
C07AB07
ATC
bisoprolol; oral
2.5
9.7
141
911
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.8
9.6
31
90
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
4.7
9.6
23
53
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.5
9.5
80
402
R11
ICD-10 Finland
Nausea and vomiting
3.6
9.5
35
111
D75.2
ICD-10 Finland
Essential thrombocytosis
+∞
9.4
9
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
4.6
9.4
23
54
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.0
9.2
28
78
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.9
9.2
52
214
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.5
9.1
35
114
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.0
8.9
44
167
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.7
8.8
21
48
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
4.0
8.7
26
71
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.5
8.6
72
359
K78
ICPC
Atrial fibrillation/flutter
3.5
8.5
32
103
SPAT1262
SPAT
Handing over of treatment supplies
2.6
8.3
56
251
N02AX02
ATC
tramadol; systemic, rectal
2.3
8.3
116
721
K86.3
ICD-10 Finland
Pseudocyst of pancreas
34.7
8.1
10
*
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
23.0
8.1
11
5
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.0
8.1
40
152
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.6
8.0
56
255
A06AD11
ATC
lactulose; oral
2.8
8.0
47
196
M10.9
ICD-10 Finland
Gout, unspecified
3.5
8.0
29
91
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
10.0
7.9
15
16
JAH00
NOMESCO Finland
Laparotomy
6.4
7.9
20
34
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
3.3
7.8
31
103
Z3231
NOMESCO Finland
Registered nurse
2.3
7.8
77
411
JN4BD
NOMESCO Finland
Extensive body CT
2.9
7.7
39
150
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.5
7.7
60
288
D47.3
ICD-10 Finland
Essential (haemorrhagic) thrombocythaemia
19.2
7.7
11
6
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.6
7.7
27
83
R50.9
ICD-10 Finland
Fever, unspecified
2.7
7.7
46
194
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.0
7.6
36
133
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
7.5
72
378
A02BC02
ATC
pantoprazole; systemic
2.4
7.5
167
1235
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.6
7.5
52
236
D70.89
ICD-10 Finland
Neutropenic splenomegaly
82.7
7.5
8
*
9961/3-C42.1
ICD-O-3
Primary myelofibrosis of bone marrow
82.7
7.5
8
*
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
6.2
7.4
19
33
K85.9
ICD-10 Finland
Acute pancreatitis, unspecified
9.9
7.4
14
15
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
4.0
7.3
21
56
K86.08
ICD-10 Finland
Alcohol-induced chronic pancreatitis
31.1
7.2
9
*
JMA10
NOMESCO Finland
Transabdominal total splenectomy
20.8
7.2
10
5
A03FA01
ATC
metoclopramide; systemic, rectal
2.4
7.0
62
313
Z51.5
ICD-10 Finland
Palliative care
3.1
7.0
31
110
N07BB01
ATC
disulfiram; oral
4.0
7.0
20
53
I50.1
ICD-10 Finland
Left ventricular failure
4.1
6.9
19
49
Y83.8
ICD-10 Finland
Other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
7.6
6.8
15
21
9950/3-C42.1
ICD-O-3
Polycythemia vera of bone marrow
41.3
6.8
8
*
A41.9
ICD-10 Finland
Sepsis, unspecified
5.8
6.8
18
33
J01MA12
ATC
levofloxacin; systemic
2.4
6.7
55
269
SPAT1255
SPAT
Intravenous administration of medicine
3.4
6.7
25
80
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
12.8
6.7
11
9
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
12.8
6.7
11
9
K55.0
ICD-10 Finland
Acute vascular disorders of intestine
12.8
6.7
11
9
WX872
NOMESCO Finland
Intensive care
3.9
6.6
20
55
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
3.1
6.6
30
108
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.7
6.5
38
157
PD5AD
NOMESCO Finland
CT of aorta
7.8
6.5
14
19
ZXD05
NOMESCO Finland
Urgent procedure
2.1
6.5
79
454
WZC00
NOMESCO Finland
Treatment plan or consultation
2.1
6.5
93
569
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
3.2
6.5
26
87
374
Kela drug reimbursment
Ruxolitinib
71.8
6.5
7
*
R4110
NOMESCO Finland
Physiotherapy
2.1
6.4
76
432
207
Kela drug reimbursment
Chronic arrhythmias
2.4
6.4
50
239
K99
ICPC
Cardiovascular disease other
7.4
6.3
14
20
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.4
6.3
53
261
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
6.6
6.3
15
24
L01XX35
ATC
anagrelide; oral
+∞
6.3
6
*
R16.1
ICD-10 Finland
Splenomegaly, not elsewhere classified
+∞
6.3
6
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.3
6.2
16
39
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.2
6.2
25
84
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.8
6.1
32
125
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.8
6.0
19
54
XF400
NOMESCO Finland
ECG with 12 standard connections
2.4
6.0
48
231
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
61
60
13.60
57.26
4.1
1.9
0.30
0.33
u/ml
0.14
49
25
183
928
6.31
29.77
32.3
13.9
1.41
1.28
inr
0.82
54
276
85
244
5.00
28.62
6.3
5.2
1.08
1.04
mmol/l
0.47
78
226
141
615
4.49
26.97
6.0
2.4
56.80
64.09
u/l
0.39
136
575
85
265
4.56
25.41
3.7
2.4
21.71
22.92
%
0.25
74
225
175
929
5.04
24.82
12.9
6.5
1.20
1.21
mmol/l
1.25
158
799
28
30
10.52
24.03
1.3
1.1
67.28
12.52
u/l
1.29
21
25
28
30
10.52
24.03
1.5
1.3
2.75
1.29
u/ml
—
16
7
29
33
9.95
23.84
1.5
1.2
8.59
5.23
u/ml
0.28
17
13
115
467
4.01
23.53
3.2
2.0
4.28
3.28
mg/l
1.72
108
402
53
123
5.33
22.52
2.0
1.6
—
—
—
0
0
184
1056
5.16
22.46
17.7
8.8
5.34
4.20
e9/l
2.64
171
929
158
849
3.92
20.27
6.2
2.6
—
—
—
0
0
87
320
3.81
20.02
3.1
1.7
—
—
—
0
0
35
65
6.20
18.74
1.2
4.0
48.37
158.60
mg/l
0.57
29
52
35
65
6.20
18.74
1.2
4.0
40.70
28.83
mg/l
0.73
29
52
25
32
8.67
18.67
1.2
1.1
—
—
—
0
0
98
409
3.48
18.30
2.5
1.8
2.12
1.45
mg/l
1.18
84
330
41
93
5.17
17.67
1.9
1.9
1.38
1.59
g/l
0.63
34
80
123
600
3.33
17.62
4.6
3.2
21.08
168.26
e6/l
0.75
107
460
126
637
3.24
16.75
4.4
3.1
1700.94
1302.07
ng/l
0.90
118
532
67
230
3.73
16.73
2.9
1.6
—
—
—
0
0
28
22
14.37
16.68
1.1
1.1
—
—
—
0
0
33
65
5.78
16.57
1.2
3.8
1.23
3.50
ratio
—
6
6
55
169
3.99
16.06
2.5
2.6
9.35
9.52
ug/l
0.02
46
154
114
558
3.12
15.79
4.4
3.0
0.34
0.42
e6/l
0.34
100
414
58
190
3.77
15.41
5.4
3.5
2.14
2.08
mmol/l
0.04
48
152
44
118
4.40
15.39
1.6
1.3
—
—
—
0
0
95
428
3.12
15.07
5.7
2.3
—
—
—
0
0
65
233
3.52
15.05
3.0
1.7
—
—
—
0
0
116
586
3.03
14.99
3.6
3.4
2.34
2.35
mmol/l
0.25
104
515
41
108
4.42
14.64
2.6
1.6
—
—
—
0
0
105
508
3.01
14.58
5.1
2.9
364.74
7235.56
umol/l
2.20
97
438
63
229
3.44
14.19
13.3
6.9
5.04
5.05
kpa
0.00
63
220
63
231
3.40
13.98
13.3
6.9
1.92
1.09
mmol/l
0.89
51
190
26
49
5.87
13.60
1.8
1.5
—
—
—
0
0
128
712
2.86
13.39
5.0
3.1
—
—
—
0
0
82
369
2.93
12.67
6.3
3.9
430.78
215.13
ng/l
0.69
73
305
26
53
5.42
12.50
1.5
1.2
—
—
—
0
0
38
107
4.07
12.35
4.7
2.7
1.51
1.24
%
0.62
38
107
50
172
3.45
12.14
6.3
2.5
35.60
33.73
u/l
0.10
43
142
57
213
3.25
12.12
3.3
4.5
10.72
26.32
ug/l
0.36
49
180
25
52
5.29
11.74
1.9
1.5
—
—
—
0
0
24
49
5.37
11.50
2.2
1.7
—
—
—
0
0
79
371
2.74
11.03
2.1
1.8
1170.71
1290.69
nmol/l
0.58
66
275
24
52
5.05
10.75
2.0
1.5
—
—
—
0
0
130
792
2.53
10.43
6.6
4.0
101.67
38.37
ng/l
0.55
111
601
20
38
5.68
10.32
1.4
1.5
—
—
—
0
0
127
775
2.47
10.02
2.7
1.9
89.70
94.73
pmol/l
0.69
88
384
21
43
5.29
10.00
1.6
1.3
—
—
—
0
0
34
104
3.68
9.77
5.0
2.7
0.59
0.65
%
0.64
34
104
185
1375
2.98
9.26
6.6
4.1
18.44
12.78
mm/h
3.82
177
1251
20
42
5.13
9.26
1.7
1.5
—
—
—
0
0
118
718
2.36
9.09
2.5
2.2
80.20
77.39
nmol/l
0.43
106
626
19
24
8.54
9.06
2.3
2.0
—
—
—
0
0
38
132
3.26
8.96
14.3
6.5
24.06
24.50
mmol/l
0.19
38
125
89
484
2.39
8.81
2.2
1.5
19.61
20.96
nmol/l
0.35
81
406
26
72
3.95
8.57
1.4
2.3
—
—
—
0
0
18
24
8.05
8.34
1.3
1.1
—
—
—
0
0
18
24
8.05
8.34
1.7
1.3
—
—
—
0
0
18
39
4.93
8.03
1.9
1.5
—
—
—
0
0
63
318
2.37
7.18
4.3
2.9
5.25
2.40
e6/l
0.75
36
170
137
950
2.14
6.98
5.9
4.1
0.00
0.00
estimate
0.50
37
202
138
962
2.13
6.90
5.9
4.0
0.00
0.00
estimate
-0.00
36
180
12
11
11.45
6.88
1.4
1.2
—
—
—
0
0
66
348
2.27
6.75
4.0
2.7
1.15
1.08
e6/l
0.09
39
196
136
948
2.11
6.74
7.8
5.5
0.00
0.00
estimate
-0.00
35
186
143
1017
2.12
6.70
3.5
2.7
—
—
—
0
0
64
339
2.24
6.45
3.4
3.4
2.48
2.45
mmol/l
0.73
54
301
17
44
4.10
6.11
1.5
1.6
—
—
—
0
0
211
1818
3.77
5.77
48.2
14.8
33.92
23.68
mg/l
5.54
206
1448
155
1170
2.05
5.77
6.8
3.2
75.58
53.27
u/l
2.44
148
1094
17
36
5.02
5.74
2.2
1.7
—
—
—
0
0
17
36
5.02
5.74
2.2
1.7
—
—
—
0
0
11
14
8.20
5.41
1.3
1.0
—
—
—
0
0
15
30
5.28
5.36
1.1
1.1
—
—
—
0
0
20
64
3.33
5.34
2.2
2.9
—
—
—
0
0
15
40
3.95
5.18
1.3
1.2
—
—
—
0
0
8
6
13.76
5.12
1.8
1.2
—
—
—
0
0
16
37
4.58
5.05
1.4
1.5
—
—
—
0
0
16
38
4.45
4.93
1.8
1.5
—
—
—
0
0
14
31
4.75
4.64
1.8
1.5
—
—
—
0
0
19
66
3.05
4.45
2.5
1.8
—
—
—
0
0
13
28
4.86
4.44
2.5
1.6
—
—
—
0
0
13
28
4.86
4.44
2.5
1.6
—
—
—
0
0
39
195
2.21
4.42
1.7
1.7
1.60
1.61
%
0.03
32
161
18
61
3.12
4.39
2.3
1.6
—
—
—
0
0
22
86
2.73
4.20
1.8
1.9
38.24
39.88
u/l
0.10
17
78
14
35
4.20
4.18
1.4
1.2
—
—
—
0
0
80
526
1.81
4.15
6.3
4.3
0.00
0.00
estimate
-0.00
31
181
48
267
2.02
4.12
1.3
1.3
24.04
11.44
u/ml
0.45
20
112
8
10
8.24
4.09
1.8
2.2
—
—
—
0
0
8
10
8.24
4.09
1.8
2.2
—
—
—
0
0
8
11
7.49
3.89
1.9
2.5
—
—
—
0
0
10
19
5.45
3.87
1.6
1.9
—
—
—
0
0
10
19
5.45
3.87
1.6
1.9
—
—
—
0
0
10
19
5.45
3.87
1.6
1.9
—
—
—
0
0
13
33
4.12
3.86
1.8
1.4
—
—
—
0
0
11
24
4.76
3.80
1.8
1.9
—
—
—
0
0
51
300
1.91
3.71
1.3
1.3
33.73
43.17
iu/ml
0.32
15
101
40
218
2.02
3.62
6.4
3.4
—
—
—
0
0
11
26
4.39
3.55
1.9
1.3
—
—
—
0
0
9
17
5.47
3.55
1.1
1.3
—
—
—
0
0
8
13
6.34
3.53
2.3
1.3
594.63
631.00
e6/l
—
8
8
11
27
4.23
3.44
3.9
1.8
32.55
34.19
pg
0.71
11
27
10
23
4.50
3.35
1.9
1.9
—
—
—
0
0
25
118
2.26
3.25
4.1
4.0
2.59
1.88
mmol/l
0.53
19
91
14
50
2.92
3.15
2.2
1.3
—
—
—
0
0
8
16
5.14
3.08
1.3
1.1
—
—
—
0
0
99
742
1.60
2.95
6.6
4.4
—
—
—
0
0
85
616
1.61
2.90
3.3
3.7
18.94
7.49
mg/mmol
0.59
66
396
7
13
5.52
2.89
2.4
1.2
—
—
—
0
0
160
1354
1.64
2.78
4.9
3.7
15.27
14.95
pmol/l
0.81
152
1203
11
34
3.35
2.77
1.2
1.4
—
—
—
0
0
11
34
3.35
2.77
1.2
1.4
—
—
—
0
0
8
19
4.33
2.70
1.9
1.5
—
—
—
0
0
10
30
3.44
2.64
1.4
1.0
—
—
—
0
0
12
42
2.96
2.59
1.1
1.4
—
—
—
0
0
5
7
7.27
2.56
1.0
2.1
—
—
—
0
0
5
7
7.27
2.56
1.0
2.1
—
—
—
0
0
7
16
4.48
2.49
1.3
1.9
12.26
12.19
umol/l
—
7
16
14
58
2.51
2.42
1.1
1.3
—
—
—
0
0
14
58
2.51
2.42
1.1
1.3
—
—
—
0
0
9
27
3.43
2.42
1.4
1.5
34.68
17.06
ug/l
—
9
27
5
8
6.36
2.38
1.0
2.1
—
—
—
0
0
5
8
6.36
2.38
1.0
2.0
—
—
—
0
0
5
8
6.36
2.38
1.0
2.1
—
—
—
0
0
6
13
4.71
2.28
1.0
1.0
—
—
—
0
0
59
414
1.58
2.24
6.7
4.7
1.01
1.02
kg/l
—
10
49
7
19
3.77
2.17
1.1
1.4
—
—
—
0
0
194
1763
1.75
2.16
37.9
14.0
75.56
78.18
ml/min/173m2
0.76
181
1446
29
170
1.81
2.13
3.8
3.6
1.22
1.22
mmol/l
0.01
29
152
8
25
3.28
2.11
1.9
1.6
—
—
—
0
0
7
20
3.58
2.07
1.1
1.4
—
—
—
0
0
7
20
3.58
2.07
1.1
1.4
—
—
—
0
0
7
20
3.58
2.07
1.1
1.4
—
—
—
0
0
7
20
3.58
2.07
1.1
1.4
—
—
—
0
0
12
50
2.48
2.06
2.4
2.5
1.54
1.75
mg/l
0.62
12
44
6
15
4.08
2.05
7.7
3.1
—
—
—
0
0
6
15
4.08
2.05
1.2
1.1
—
—
—
0
0
198
1818
1.77
2.01
5.4
4.8
6.36
6.03
mmol/l
1.92
178
1643
7
21
3.41
1.98
1.1
1.3
—
—
—
0
0
10
39
2.64
1.97
9.2
3.9
59.30
60.85
%
—
10
39
6
16
3.82
1.95
1.3
1.3
—
—
—
0
0
185
1675
1.60
1.92
5.8
4.5
1.89
1.96
mu/l
0.35
179
1502
6
17
3.60
1.85
1.2
1.1
—
—
—
0
0
5
13
3.91
1.72
1.0
1.3
1.53
1.53
g/l
—
5
13
10
41
2.50
1.66
1.1
1.3
—
—
—
0
0
6
20
3.05
1.59
1.3
1.4
—
—
—
0
0
189
1741
1.55
1.58
7.8
6.1
41.93
40.39
mmol/mol
1.00
175
1611
5
15
3.38
1.53
1.0
1.5
—
—
—
0
0
34
232
1.55
1.45
17.6
7.9
—
—
—
0
0
5
16
3.17
1.44
1.4
1.1
—
—
—
0
0
57
435
1.42
1.41
1.8
1.8
471.16
434.67
pmol/l
0.42
50
351
188
1749
1.47
1.29
5.1
4.2
1.51
1.27
mmol/l
3.70
169
1596
8
37
2.20
1.22
1.4
1.4
—
—
—
0
0
49
374
1.40
1.21
1.4
1.2
1.04
1.52
u/ml
0.38
11
112
5
20
2.53
1.15
1.2
1.3
—
—
—
0
0
15
88
1.76
1.14
1.3
1.3
—
—
—
0
0
5
22
2.30
1.04
1.4
1.1
—
—
—
0
0
5
22
2.30
1.04
1.4
1.1
—
—
—
0
0
5
22
2.30
1.04
1.4
1.1
—
—
—
0
0
5
22
2.30
1.04
1.4
1.1
—
—
—
0
0
5
22
2.30
1.04
1.4
1.1
—
—
—
0
0
10
53
1.93
1.03
1.8
1.5
—
—
—
0
0
7
36
1.97
0.98
5.0
3.6
103.71
105.92
mmol/l
—
7
36
211
2033
1.65
0.96
67.6
21.7
37.93
40.15
%
5.76
194
1908
211
2035
1.64
0.92
67.4
21.6
124.42
135.59
g/l
14.67
211
2003
6
32
1.90
0.82
2.0
3.9
—
—
—
0
0
9
53
1.73
0.76
1.6
1.9
—
—
—
0
0
190
1813
1.32
0.74
5.4
4.7
4.03
4.55
mmol/l
10.45
175
1664
14
203
0.67
0.71
1.4
1.4
—
—
—
0
0
7
41
1.73
0.70
1.0
1.1
—
—
—
0
0
5
27
1.87
0.69
1.0
1.1
—
—
—
0
0
194
1861
1.32
0.68
6.0
5.2
2.33
2.69
mmol/l
7.17
178
1700
13
87
1.52
0.65
1.3
1.2
231.62
465.73
u/ml
0.35
13
81
12
82
1.49
0.55
1.1
1.0
—
—
—
0
0
21
163
1.32
0.50
4.8
3.1
55.62
61.58
ml/min/173m2
0.33
13
72
187
1804
1.22
0.48
5.5
4.6
1.18
1.44
mmol/l
14.15
168
1650
7
50
1.41
0.45
1.7
1.7
7.27
3.49
mg/l
—
7
38
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
1.0
—
34.88
—
0
8
0
17
0.00
0.41
0.0
1.0
—
507.11
—
0
9
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
220.92
—
0
10
0
10
0.00
0.21
0.0
1.7
—
8.01
—
0
10
5
43
1.17
0.21
1.0
1.5
—
—
—
0
0
6
49
1.23
0.20
2.5
1.7
—
—
—
0
0
7
58
1.21
0.18
2.6
1.8
—
—
—
0
0
30
275
1.10
0.15
1.5
1.5
—
—
—
0
0
59
611
0.95
0.08
3.5
4.6
22.39
21.19
%
0.19
25
312
78
771
1.02
0.02
4.8
5.0
6.39
2.77
ug/l
0.61
66
689
22
226
0.97
0.00
5.6
4.6
31.67
31.86
%
0.02
15
152
12
121
0.99
0.00
1.7
1.8
—
—
—
0
0
13
131
0.99
0.00
1.8
2.0
—
—
—
0
0
44
441
1.00
0.00
2.3
3.1
0.64
0.82
ug/l
0.76
27
300
16
155
1.03
0.00
2.2
2.1
9.56
13.39
nmol/l
0.82
16
141
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
26.26
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_INFARCTSPLEEN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_INFARCTSPLEEN | 4.274 [2.49, 7.33] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.268 |
During the follow-up period (1.1.1998 — 31.12.2019), 141 out of 337 females with D3_INFARCTSPLEEN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_INFARCTSPLEEN | 3.945 [2.59, 6.01] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 157 out of 407 males with D3_INFARCTSPLEEN died.
Mortality risk
Mortality risk for people of age
years, who have D3_INFARCTSPLEEN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.375% | 0.58% |
| 5 | 2.654% | 3.864% |
| 10 | 6.187% | 9.639% |
| 15 | 12.077% | 17.816% |
| 20 | 20.399% | 28.01% |
Relationships between endpoints
↥Index endpoint: D3_INFARCTSPLEEN – Infarction of spleen
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data