splenic disease: A disease involving the spleen.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
145 |
4. Check minimum number of eventsNone |
145 |
5. Include endpointsNone |
145 |
6. Filter based on genotype QC (FinnGen only) |
145 |
Control definitions (FinnGen only)
- Control exclude
- D3_BLOODOTHER
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified diseases of spleen
based on the number of shared cases.
Similar with more cases:
- Diseases of spleen
- Other diseases of blood and blood-forming organs, wide
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 905 | 489 | 409 |
| Only index persons | 758 | 427 | 331 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 58.59 | 60.01 | 56.88 |
| Only index persons | 56.10 | 56.89 | 55.07 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 145 | 77 | 68 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 57.33 | 56.66 | 58.10 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 132
- Matched controls
- 1320
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D73.9
ICD-10 Finland
Disease of spleen, unspecified
+∞
87.5
74
*
D73.8
ICD-10 Finland
Other diseases of spleen
+∞
55.1
49
*
JMA10
NOMESCO Finland
Transabdominal total splenectomy
145.3
23.4
24
*
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
+∞
14.9
14
*
XW000
NOMESCO Finland
Bone marrow biopsy
15.2
14.1
23
18
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
23.8
9.6
13
6
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
10.1
8.8
17
19
J01MA12
ATC
levofloxacin; systemic
3.9
8.8
39
127
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.2
8.5
34
100
D73.5
ICD-10 Finland
Infarction of spleen
+∞
8.4
8
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.0
7.5
54
248
R16.1
ICD-10 Finland
Splenomegaly, not elsewhere classified
84.6
7.5
8
*
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
73
376
2.90
9.07
5.0
2.4
52.3
54.6
u/l
0.32
66
345
87
516
2.72
7.90
9.0
3.9
—
—
—
0
0
90
543
2.73
7.89
16.0
6.5
1.2
1.2
mmol/l
0.31
69
459
46
202
2.87
7.46
1.9
1.7
1128.5
1148.7
nmol/l
0.05
38
154
57
284
2.66
7.22
3.7
2.8
7557.0
3443.3
umol/l
0.23
49
243
38
157
2.92
6.83
3.7
2.4
22.5
23.2
%
0.09
33
136
51
267
2.40
5.60
2.7
2.0
4.4
3.1
mg/l
1.93
43
231
78
490
2.28
5.59
13.9
5.6
1.2
1.2
mmol/l
0.70
70
448
49
253
2.41
5.54
1.5
1.8
1.3
0.9
mg/l
0.42
38
201
96
663
2.33
5.42
12.6
9.8
4.1
4.1
e9/l
0.06
87
590
10
18
5.89
5.40
3.8
3.6
51.8
55.4
%
—
10
18
26
99
2.98
5.34
2.5
2.5
0.2
0.2
g/l
0.40
26
92
67
404
2.22
5.21
3.8
3.3
—
—
—
0
0
19
66
3.16
4.53
4.8
2.9
5.3
5.1
kpa
0.34
19
59
54
318
2.11
4.30
3.6
3.2
0.2
0.4
e6/l
0.95
44
236
68
444
2.00
4.03
4.7
3.7
—
—
—
0
0
28
128
2.47
4.03
2.0
4.2
4.5
4.7
ug/l
0.02
21
108
114
899
2.25
3.97
13.6
7.3
81.4
75.6
u/l
0.89
108
846
15
50
3.23
3.81
4.7
2.4
1.1
1.4
%
0.29
15
50
46
267
2.06
3.73
3.3
2.1
—
—
—
0
0
11
30
3.89
3.71
1.2
2.1
—
—
—
0
0
12
37
3.45
3.42
1.9
1.8
—
—
—
0
0
66
445
1.89
3.42
2.5
2.0
86.3
96.3
pmol/l
1.33
43
235
9
19
4.98
3.29
1.4
1.2
—
—
—
0
0
104
821
1.94
3.21
4.1
2.9
67.5
47.0
u/l
0.77
94
779
10
29
3.63
3.11
3.3
2.7
23.5
25.0
mmol/l
—
10
23
6
8
7.76
3.08
1.0
1.1
—
—
—
0
0
7
12
6.07
3.06
1.6
1.2
—
—
—
0
0
16
65
2.64
2.90
9.1
2.4
118.1
131.2
g/l
1.16
16
65
11
36
3.22
2.87
1.9
1.8
—
—
—
0
0
12
42
3.02
2.82
4.1
2.9
—
—
—
0
0
12
42
3.02
2.82
4.1
2.9
2.9
3.9
g/l
—
6
33
12
42
3.02
2.82
4.1
2.9
6.1
7.9
g/l
—
6
35
77
576
1.72
2.62
6.2
4.8
0.0
0.0
estimate
0.00
21
116
76
569
1.71
2.56
4.6
3.6
0.0
0.0
estimate
0.00
21
114
77
583
1.68
2.45
4.6
3.6
0.0
0.0
estimate
0.00
20
107
13
52
2.65
2.43
6.0
3.4
49.7
47.2
%
0.14
13
52
5
8
6.42
2.39
3.0
1.8
6.3
4.0
mg/l
—
5
8
106
879
1.77
2.37
6.3
4.2
16.6
11.5
mm/h
1.79
101
815
8
23
3.62
2.30
5.4
1.3
—
—
—
0
0
8
23
3.62
2.30
1.3
1.7
—
—
—
0
0
32
193
1.84
2.24
2.6
1.9
—
—
—
0
0
18
88
2.19
2.22
2.4
1.4
—
—
—
0
0
8
25
3.32
2.13
1.3
1.7
—
—
—
0
0
130
1163
2.14
2.10
29.1
13.6
23.7
22.8
mg/l
0.12
122
911
6
15
4.12
2.06
1.0
1.5
13.0
14.2
ug/l
—
6
15
7
21
3.45
1.99
1.3
1.7
—
—
—
0
0
44
303
1.65
1.94
4.8
4.0
0.0
0.0
estimate
0.00
18
109
0
52
0.00
1.92
0.0
1.9
—
6.4
—
0
35
62
466
1.58
1.90
3.2
2.4
69.9
76.7
nmol/l
1.17
55
422
8
28
2.96
1.89
1.3
1.3
—
—
—
0
0
22
124
1.91
1.89
5.8
3.1
—
—
—
0
0
102
862
1.62
1.87
5.5
3.9
14.8
14.8
pmol/l
0.01
94
794
5
12
4.27
1.84
1.0
1.3
—
—
—
0
0
52
378
1.59
1.83
7.1
3.1
2.3
2.3
mmol/l
0.09
47
334
8
29
2.86
1.82
1.3
1.6
—
—
—
0
0
6
18
3.43
1.76
2.0
2.2
—
—
—
0
0
8
30
2.76
1.75
1.1
1.3
—
—
—
0
0
8
30
2.76
1.75
1.9
1.8
—
—
—
0
0
6
20
3.08
1.60
2.0
2.1
—
—
—
0
0
28
180
1.69
1.58
3.2
2.8
1.5
0.7
e6/l
0.60
16
103
121
1088
1.68
1.51
22.8
13.0
79.2
81.5
ml/min/173m2
0.45
97
894
27
176
1.66
1.45
1.5
1.4
—
—
—
0
0
9
40
2.33
1.43
1.3
3.2
—
—
—
0
0
26
169
1.66
1.41
3.4
3.0
5.5
2.3
e6/l
0.68
13
94
12
61
2.05
1.37
1.9
1.2
—
—
—
0
0
5
17
3.01
1.37
1.2
1.3
—
—
—
0
0
5
17
3.01
1.37
1.2
1.3
—
—
—
0
0
5
17
3.01
1.37
1.2
1.3
—
—
—
0
0
5
17
3.01
1.37
1.2
1.3
—
—
—
0
0
10
48
2.16
1.31
2.5
2.0
—
—
—
0
0
5
18
2.84
1.29
1.2
1.3
—
—
—
0
0
5
18
2.84
1.29
1.2
1.3
—
—
—
0
0
9
44
2.11
1.29
1.9
1.9
—
—
—
0
0
21
133
1.68
1.26
2.2
1.7
—
—
—
0
0
6
25
2.46
1.25
3.5
1.8
—
—
—
0
0
22
143
1.63
1.20
4.3
4.4
35.6
31.2
%
0.98
17
97
6
26
2.36
1.20
1.0
1.7
—
—
—
0
0
6
26
2.36
1.20
1.0
1.3
—
—
—
0
0
5
112
0.43
1.19
1.2
1.8
—
—
—
0
0
5
20
2.55
1.16
1.2
1.8
—
—
—
0
0
8
40
2.06
1.14
2.3
2.4
—
—
—
0
0
14
81
1.81
1.13
4.9
3.5
210.4
124.7
ng/l
0.37
14
74
132
1240
1.72
1.05
17.0
10.0
26.1
25.9
u/l
0.06
126
1206
35
264
1.43
0.99
1.2
1.3
1.1
2.0
u/ml
—
6
78
7
36
1.99
0.98
1.4
1.1
—
—
—
0
0
7
36
1.99
0.98
1.3
1.2
—
—
—
0
0
20
135
1.56
0.95
2.4
1.8
—
—
—
0
0
7
37
1.94
0.95
1.3
1.2
—
—
—
0
0
38
294
1.40
0.93
1.8
1.7
19.7
22.5
nmol/l
0.40
29
249
6
29
2.11
0.90
1.5
3.7
0.0
0.0
g/l
—
6
29
27
198
1.45
0.88
1.4
1.3
17.1
36.8
iu/ml
—
5
73
26
191
1.44
0.85
1.4
1.3
1.1
6.9
u/ml
—
7
77
55
460
1.32
0.82
5.8
3.6
38.3
38.6
ng/l
0.01
43
307
11
66
1.72
0.81
4.6
3.2
0.2
0.1
e6/l
0.39
11
61
17
116
1.53
0.78
13.9
8.0
—
—
—
0
0
29
223
1.38
0.74
5.2
3.5
803.2
133.8
ng/l
0.47
23
171
5
28
1.81
0.67
1.0
1.2
—
—
—
0
0
5
28
1.81
0.67
1.2
1.4
2.0
12.9
e6/l
—
5
21
5
28
1.81
0.67
1.2
1.5
2.6
38.2
e6/l
—
5
23
7
44
1.62
0.66
1.3
1.2
39.9
24.5
iu/l
—
7
37
0
23
0.00
0.59
0.0
1.5
—
—
—
0
0
9
62
1.48
0.54
1.2
1.5
—
—
—
0
0
113
1066
1.27
0.54
6.5
4.5
1.9
1.9
mu/l
0.06
104
973
6
39
1.56
0.53
1.8
1.5
—
—
—
0
0
9
63
1.46
0.53
2.4
1.3
—
—
—
0
0
7
47
1.51
0.48
2.4
1.6
—
—
—
0
0
114
1082
1.25
0.47
25.3
14.1
37.2
40.5
%
1.87
76
804
0
16
0.00
0.41
0.0
2.0
—
—
—
0
0
27
319
0.81
0.39
1.8
1.6
2.8
1.4
mmol/l
0.78
22
267
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
113
1090
1.17
0.28
6.4
5.6
41.5
39.7
mmol/mol
0.71
99
1027
121
1174
1.19
0.27
5.1
4.8
2.5
2.8
mmol/l
1.74
108
1095
115
1113
1.16
0.26
4.5
3.9
1.5
1.3
mmol/l
1.59
101
1030
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
6.7
—
0
5
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
118
1156
1.11
0.15
4.6
4.4
4.4
4.7
mmol/l
2.03
107
1083
115
1127
1.10
0.13
5.2
4.4
6.1
5.9
mmol/l
0.58
103
1046
117
1149
1.09
0.12
4.7
4.4
1.3
1.5
mmol/l
3.78
104
1068
78
756
1.07
0.11
3.0
3.1
—
—
—
0
0
6
57
1.05
0.08
1.0
1.1
—
—
—
0
0
13
120
1.09
0.05
2.2
1.6
—
—
—
0
0
30
307
0.97
0.01
3.8
4.2
19.7
20.9
%
0.20
17
140
39
397
0.98
0.01
4.3
4.6
2.7
3.1
ug/l
0.17
33
358
22
224
0.98
0.00
3.7
2.9
0.7
0.9
ug/l
0.43
15
144
13
133
0.98
0.00
2.3
1.7
—
—
—
0
0
23
227
1.02
0.00
1.3
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
6
61
0.98
0.00
1.3
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
4.0
—
—
—
0
0
0
7
0.00
0.00
0.0
4.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_SPLEENNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_SPLEENNAS | 3.05 [2.07, 4.49] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.19 |
During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 308 females with D3_SPLEENNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_SPLEENNAS | 2.705 [1.59, 4.59] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.017 |
During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 259 males with D3_SPLEENNAS died.
Mortality risk
Mortality risk for people of age
years, who have D3_SPLEENNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.325% | 0.504% |
| 5 | 1.613% | 2.996% |
| 10 | 4.027% | 8.117% |
| 15 | 7.92% | 15.309% |
| 20 | 13.948% | 25.008% |
Relationships between endpoints
↥Index endpoint: D3_SPLEENNAS – Other and unspecified diseases of spleen
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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