splenic disease: A disease involving the spleen.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
154 |
4. Check minimum number of eventsNone |
154 |
5. Include endpointsNone |
154 |
6. Filter based on genotype QC (FinnGen only) |
145 |
Control definitions (FinnGen only)
- Control exclude
- D3_BLOODOTHER
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified diseases of spleen
based on the number of shared cases.
Similar with more cases:
- Diseases of spleen
- Other diseases of blood and blood-forming organs, wide
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 905 | 489 | 409 |
| Only index persons | 758 | 427 | 331 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 58.59 | 60.01 | 56.88 |
| Only index persons | 56.10 | 56.89 | 55.07 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 145 | 76 | 69 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 58.11 | 57.41 | 58.88 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 154
- Matched controls
- 1540
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D73.9
ICD-10 Finland
Disease of spleen, unspecified
+∞
100.3
85
*
D73.8
ICD-10 Finland
Other diseases of spleen
+∞
64.1
57
*
JMA10
NOMESCO Finland
Transabdominal total splenectomy
162.4
26.5
27
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.4
18.2
44
106
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
189.7
16.8
17
*
XW000
NOMESCO Finland
Bone marrow biopsy
11.8
14.1
26
26
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.3
11.4
67
294
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
25.5
10.4
14
6
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.4
9.7
27
71
D64.9
ICD-10 Finland
Anaemia, unspecified
4.1
9.6
30
86
J01MA12
ATC
levofloxacin; systemic
3.3
9.6
45
170
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
4.1
9.5
29
82
TPH04
NOMESCO Finland
Cathetrisation of vein
3.1
8.7
47
193
R16.1
ICD-10 Finland
Splenomegaly, not elsewhere classified
95.0
8.5
9
*
D73.5
ICD-10 Finland
Infarction of spleen
+∞
8.4
8
*
JN4AD
NOMESCO Finland
Body CT examination
4.0
8.4
26
74
M04AA01
ATC
allopurinol; systemic
3.5
7.9
31
104
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
7.6
84
492
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
9.5
7.2
14
16
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.6
7.1
26
83
X59
ICD-10 Finland
Exposure to unspecified factor
2.9
7.0
38
155
B01AB05
ATC
enoxaparin; parenteral
2.5
6.8
58
296
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
23.7
6.8
9
*
SPAT1255
SPAT
Intravenous administration of medicine
4.3
6.6
18
46
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
6.0
6.5
17
31
R50.9
ICD-10 Finland
Fever, unspecified
2.9
6.3
34
137
2895A
ICD-9 Finland
Other diseases of blood and blood-forming organs, Other diseases of spleen
+∞
6.3
6
*
D73.1
ICD-10 Finland
Hypersplenism
+∞
6.3
6
*
UJF32
NOMESCO Finland
Coloscopy
2.5
6.2
51
255
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
9.2
6.2
12
14
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
101
550
3.43
12.15
11.4
13.5
1.19
1.24
inr
0.34
41
169
80
404
3.04
10.51
5.1
2.4
55.61
54.62
u/l
0.11
74
370
94
542
2.88
9.32
4.4
2.5
—
—
—
0
0
62
300
2.79
8.43
3.7
2.8
6766.84
3241.91
umol/l
0.22
55
260
49
210
2.96
8.34
1.8
1.7
1143.85
1165.22
nmol/l
0.05
41
160
95
574
2.71
8.24
15.5
6.3
1.21
1.22
mmol/l
0.50
74
487
41
163
3.07
7.92
3.5
2.3
22.05
23.48
%
0.22
35
141
29
104
3.20
6.60
2.4
2.5
0.22
0.21
g/l
0.22
29
97
55
278
2.52
6.59
2.7
2.0
4.23
3.12
mg/l
1.70
47
241
83
519
2.30
6.03
13.4
5.5
1.21
1.22
mmol/l
0.66
74
475
52
268
2.42
5.88
1.5
1.8
1.24
0.90
mg/l
0.38
40
214
103
710
2.36
5.88
12.4
9.5
4.06
4.12
e9/l
0.09
94
633
72
429
2.27
5.81
3.7
3.2
—
—
—
0
0
30
135
2.52
4.45
1.9
4.4
4.56
5.00
ug/l
0.07
22
114
122
958
2.32
4.38
13.7
7.4
81.53
75.49
u/l
1.04
116
901
11
20
5.83
4.38
3.6
3.4
51.82
55.35
%
0.31
11
20
16
51
3.39
4.35
5.3
2.4
0.68
0.67
%
0.05
16
51
57
340
2.07
4.33
3.6
3.2
0.22
0.41
e6/l
0.85
47
254
49
278
2.12
4.23
3.2
2.1
—
—
—
0
0
16
54
3.19
3.98
5.3
2.5
1.13
1.35
%
0.34
16
54
72
479
1.94
3.95
4.9
3.6
—
—
—
0
0
71
473
1.93
3.86
2.4
1.9
87.01
96.65
pmol/l
1.26
46
249
10
20
5.27
3.76
3.3
3.3
3.90
3.89
e9/l
—
10
20
10
20
5.27
3.76
1.6
1.2
—
—
—
0
0
12
32
3.98
3.47
1.2
2.0
—
—
—
0
0
111
875
1.96
3.46
4.1
2.9
67.55
46.42
u/l
0.89
101
829
29
144
2.25
3.44
10.2
7.0
103.66
104.09
mmol/l
0.18
29
144
13
43
3.21
3.34
3.8
2.8
—
—
—
0
0
17
68
2.69
3.17
9.3
2.5
117.18
131.84
g/l
1.45
17
68
7
12
6.05
3.05
1.6
1.2
—
—
—
0
0
83
617
1.75
2.92
6.5
4.7
0.00
0.00
estimate
-0.00
23
125
12
39
3.25
2.84
1.9
1.8
—
—
—
0
0
35
201
1.96
2.84
2.6
1.8
—
—
—
0
0
82
611
1.73
2.83
4.8
3.5
0.00
0.00
estimate
-0.00
26
132
14
54
2.75
2.79
6.5
3.4
48.81
48.60
%
0.01
14
54
114
938
1.83
2.73
6.7
4.2
16.75
11.29
mm/h
2.12
109
867
9
24
3.92
2.72
4.9
1.3
—
—
—
0
0
6
11
5.62
2.57
1.0
1.2
—
—
—
0
0
7
16
4.53
2.50
3.9
2.8
100.71
106.63
mmol/l
—
7
16
82
626
1.66
2.48
4.8
3.5
0.00
0.00
estimate
-0.00
21
116
11
38
3.04
2.47
1.9
1.8
—
—
—
0
0
5
8
6.41
2.39
1.4
1.3
—
—
—
0
0
5
8
6.41
2.39
3.0
1.7
6.34
4.00
mg/l
—
5
8
7
17
4.26
2.39
1.0
1.5
12.00
14.26
ug/l
—
7
17
24
128
2.04
2.38
5.5
3.1
—
—
—
0
0
139
1241
2.23
2.34
29.1
13.4
24.28
22.12
mg/l
0.34
131
970
19
94
2.17
2.27
2.3
1.4
—
—
—
0
0
67
495
1.63
2.25
3.1
2.4
69.32
76.42
nmol/l
1.29
60
447
8
25
3.32
2.12
1.3
1.7
—
—
—
0
0
8
25
3.32
2.12
1.3
1.7
—
—
—
0
0
9
31
3.02
2.11
1.2
1.6
—
—
—
0
0
0
57
0.00
2.10
0.0
1.8
—
6.25
—
0
40
47
325
1.64
2.02
4.8
3.8
0.00
0.00
estimate
-0.00
20
117
109
920
1.63
2.02
5.6
3.8
14.66
14.73
pmol/l
0.10
101
844
55
396
1.60
2.01
6.8
3.3
2.33
2.34
mmol/l
0.20
50
352
9
33
2.83
1.96
1.2
1.3
—
—
—
0
0
8
27
3.07
1.96
2.3
1.9
—
—
—
0
0
8
27
3.07
1.96
2.3
1.9
—
—
—
0
0
9
34
2.75
1.90
1.1
1.3
—
—
—
0
0
24
140
1.85
1.85
2.3
1.7
—
—
—
0
0
7
23
3.14
1.82
1.3
1.7
—
—
—
0
0
6
18
3.42
1.76
1.7
1.9
—
—
—
0
0
6
18
3.42
1.76
2.0
2.2
—
—
—
0
0
6
18
3.42
1.76
1.7
1.9
—
—
—
0
0
8
30
2.76
1.75
1.9
1.8
—
—
—
0
0
30
192
1.70
1.71
3.2
2.8
1.39
0.72
e6/l
0.57
18
111
13
63
2.16
1.65
1.9
1.2
—
—
—
0
0
6
20
3.08
1.59
2.0
2.1
—
—
—
0
0
5
126
0.38
1.58
1.2
1.7
—
—
—
0
0
129
1163
1.67
1.55
22.3
12.8
79.53
81.68
ml/min/173m2
0.43
104
960
5
15
3.41
1.53
1.0
1.3
—
—
—
0
0
34
232
1.60
1.52
4.9
3.4
742.25
128.94
ng/l
0.47
25
178
42
302
1.54
1.50
1.7
1.7
18.93
22.41
nmol/l
0.61
33
255
10
45
2.31
1.50
1.3
3.0
—
—
—
0
0
23
142
1.73
1.49
2.4
1.7
—
—
—
0
0
9
39
2.39
1.45
1.3
1.2
—
—
—
0
0
39
281
1.52
1.37
1.3
1.3
1.03
1.97
u/ml
—
7
81
28
187
1.61
1.36
1.5
1.4
—
—
—
0
0
27
181
1.60
1.30
3.3
3.1
5.57
2.10
e6/l
0.82
14
102
9
44
2.11
1.29
2.4
2.5
—
—
—
0
0
6
25
2.45
1.25
3.5
1.8
—
—
—
0
0
10
49
2.11
1.25
2.5
2.0
—
—
—
0
0
15
86
1.82
1.24
4.6
3.4
199.07
120.97
ng/l
0.36
15
79
61
489
1.41
1.24
5.9
3.6
37.14
43.80
ng/l
0.19
47
329
5
19
2.68
1.22
1.2
1.3
—
—
—
0
0
5
19
2.68
1.22
1.2
1.3
—
—
—
0
0
5
19
2.68
1.22
1.2
1.3
—
—
—
0
0
5
19
2.68
1.22
1.2
1.3
—
—
—
0
0
6
26
2.36
1.20
1.0
1.7
—
—
—
0
0
141
1323
1.78
1.17
17.1
10.0
26.52
25.88
u/l
0.17
135
1286
5
20
2.55
1.16
1.2
1.8
—
—
—
0
0
5
20
2.55
1.16
1.2
1.3
—
—
—
0
0
5
20
2.55
1.16
1.2
1.3
—
—
—
0
0
5
21
2.43
1.10
1.0
1.2
1.53
1.38
g/l
—
5
16
23
155
1.57
1.09
4.2
4.3
35.17
31.36
%
0.85
18
107
9
45
2.06
1.07
1.9
1.9
—
—
—
0
0
29
211
1.46
0.98
1.4
1.3
150.13
35.45
iu/ml
—
6
78
12
70
1.77
0.95
4.3
3.2
0.19
0.08
e6/l
0.38
12
65
7
37
1.93
0.95
1.3
1.2
—
—
—
0
0
6
28
2.19
0.92
1.0
1.3
—
—
—
0
0
28
205
1.45
0.92
1.4
1.3
1.09
6.72
u/ml
—
7
81
6
30
2.04
0.88
1.5
3.6
0.00
0.00
g/l
—
6
30
8
46
1.78
0.84
1.3
1.2
35.43
23.91
iu/l
—
8
38
8
48
1.70
0.80
2.1
1.6
—
—
—
0
0
7
38
1.88
0.74
1.3
1.2
—
—
—
0
0
144
1383
1.63
0.73
41.8
19.7
38.13
40.50
%
2.91
137
1300
14
93
1.56
0.72
2.9
3.0
47.44
64.13
ml/min/173m2
—
9
40
7
40
1.78
0.72
1.7
1.5
—
—
—
0
0
144
1385
1.61
0.70
41.8
19.7
4.32
4.52
e12/l
3.42
139
1352
43
356
1.29
0.67
5.3
3.8
19.94
9.65
mg/mmol
0.66
33
221
5
29
1.75
0.64
1.2
1.5
2.60
227.42
e6/l
—
5
24
5
29
1.75
0.64
1.2
1.4
2.00
12.95
e6/l
—
5
22
5
29
1.75
0.64
1.0
1.2
—
—
—
0
0
121
1136
1.30
0.64
6.5
4.5
1.89
1.91
mu/l
0.09
112
1035
10
65
1.58
0.57
1.2
1.5
—
—
—
0
0
17
126
1.39
0.54
13.9
7.7
—
—
—
0
0
9
65
1.41
0.51
2.4
1.3
—
—
—
0
0
122
1163
1.24
0.45
6.1
5.6
41.03
39.66
mmol/mol
0.55
108
1099
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
124
1193
1.20
0.35
4.4
3.9
1.48
1.29
mmol/l
1.34
110
1104
130
1257
1.22
0.34
5.0
4.8
2.59
2.77
mmol/l
1.33
117
1175
5
38
1.33
0.23
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
8.06
—
0
11
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
127
1239
1.14
0.21
4.6
4.4
4.44
4.67
mmol/l
1.55
116
1163
0
14
0.00
0.20
0.0
1.4
—
187.39
—
0
14
126
1231
1.13
0.19
4.7
4.3
1.31
1.46
mmol/l
3.28
113
1146
123
1203
1.11
0.16
5.1
4.3
6.04
5.93
mmol/l
0.36
111
1116
31
336
0.90
0.15
1.9
1.6
2.53
1.38
mmol/l
0.75
26
280
83
802
1.08
0.14
3.0
3.0
—
—
—
0
0
23
247
0.92
0.09
3.6
3.0
0.71
0.85
ug/l
0.37
15
159
5
62
0.80
0.08
1.4
1.5
—
—
—
0
0
23
238
0.96
0.02
1.3
1.6
—
—
—
0
0
13
137
0.94
0.01
2.3
1.7
—
—
—
0
0
33
337
0.97
0.01
4.3
4.2
20.30
21.23
%
0.16
20
153
13
124
1.05
0.00
2.2
1.6
—
—
—
0
0
43
432
0.99
0.00
4.4
4.6
2.58
2.99
ug/l
0.19
37
389
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
5.1
—
—
—
0
0
0
8
0.00
0.00
0.0
5.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
1.18
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint D3_SPLEENNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_SPLEENNAS | 3.05 [2.07, 4.49] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.19 |
During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 308 females with D3_SPLEENNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_SPLEENNAS | 2.705 [1.59, 4.59] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.017 |
During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 259 males with D3_SPLEENNAS died.
Mortality risk
Mortality risk for people of age
years, who have D3_SPLEENNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.325% | 0.504% |
| 5 | 1.613% | 2.996% |
| 10 | 4.027% | 8.117% |
| 15 | 7.92% | 15.309% |
| 20 | 13.948% | 25.008% |
Relationships between endpoints
↥Index endpoint: D3_SPLEENNAS – Other and unspecified diseases of spleen
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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