≡ Risteys
R14

Documentation Changelog GitHub Contact & Feedback

Transient retinal artery occlusion

DOID PheWeb R13 (public) Endpoint Browser PheWeb

H7_RETARTOCCTRANS

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519870

1. Apply sex-specific rule

None

519870

2. Check conditions

None

519870

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H34.0
  • Cause of death: ICD-10 — H34.0

2 out of 7 registries used, show all original rules.

80

4. Check minimum number of events

None

80

5. Include endpoints

None

80

6. Filter based on genotype QC (FinnGen only)

79

Control definitions (FinnGen only)

Control exclude
H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H34
Name in latin
Occlusio arteriae retinalis transitoria

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 494 232 259
Only index persons 457 219 238
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 69.25 71.14 67.63
Only index persons 68.72 70.55 67.03

-FinnGen-

Key figures

All Female Male
Number of individuals 79 40 39
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 65.25 64.18 66.35

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
80
Matched controls
800
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H34.0
ICD-10 Finland
Transient retinal artery occlusion
+∞
115.1
80
*
H34.2
ICD-10 Finland
Other retinal artery occlusions
+∞
19.6
18
*
H34.8
ICD-10 Finland
Other retinal vascular occlusions
212.5
17.2
17
*
XCK10
NOMESCO Finland
Photography of fundus of eye
8.4
15.7
25
41
H34.1
ICD-10 Finland
Central retinal artery occlusion
+∞
15.1
14
*
CKC12
NOMESCO Finland
Photocoagulation of retina
167.2
13.9
14
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.2
11.0
31
87
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
12.5
10.2
18
18
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
41.9
9.3
11
*
XCD20
NOMESCO Finland
Photoangiography of eye
100.2
8.6
9
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
7.7
8.6
20
33
XCW99
NOMESCO Finland
Other investigative procedure of eye
8.0
7.6
17
26
AA1AD
NOMESCO Finland
CT of head and brain
3.7
7.6
43
193
XCK00
NOMESCO Finland
Perimetry
8.0
7.3
16
24
G45.3
ICD-10 Finland
Amaurosis fugax
16.1
6.6
10
7
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
75.6
6.5
7
*

TimeCodeWAS

↥

TimeCodeWAS is a tool for exploring time-dependent associations between an endpoint and health codes (diagnoses, lab tests, procedures, etc.).

The TimeCodeWAS analysis is done in three steps:

  1. Build a matched case-control set for this endpoint. Each case is matched to 5–10 controls on sex and year of birth, and controls must be at risk at the same age as the case's age of onset. TimeCodeWAS allows for controls to be reused.
  2. Count cases and controls. For each health code, and for each time window: tally the counts into a 2×2 table. To be eligible in a time window, a case or control must have data coverage for at least 50% of that time window.
  3. Perform association tests. If all cells of the 2×2 table have N≥10, then a χ² test is performed, otherwise a Fisher's exact test is done. The corresponding p-value and confidence interval are reported below, along with the standard odds ratio when a χ² test is done, or Fisher's MLE odds ratio otherwise.

TimeCodeWAS currently uses the same default set of time windows for all the endpoints. Please reach out to us if you have suggestions for better time windows for some endpoints. The default time windows are: TimeCodeWAS time windows

Sort & Filter
Sort
Odds Ratio
among windows:
Filter
Code & OMOP
Cases and controls with code
in
Odds Ratio
in
OMOP Concept
Code (OMOP Vocabulary) [OMOP Concept ID]
OMOP Concept Class / OMOP Domain
Odds Ratio
TimeCodeWAS O.R. time legend
Cases and controls with code
TimeCodeWAS Cases and Controls percentages time legend
Outpatient Visit
OP (Visit) [9202]
Visit / Visit
9.1e-01 1.3e+00 1.2e+00 4.8e+00 1.8e+00 2.3e+00 —
85.00%/69.50% 77.50%/48.38% 27.50%/10.38% 42.50%/0.63% 43.04%/10.88% 90.91%/50.00% —/—
Ophthalmology
18 (Medicare Specialty) [38004463]
Physician Specialty / Provider
1.6e+00 2.4e+00 2.8e+00 — 3.9e+00 3.2e+00 1.6e+00
38.75%/11.25% 36.25%/4.88% 16.25%/1.13% —/— 24.05%/0.63% 57.14%/5.12% 51.47%/17.90%
Case Management Agency
251B00000X (NUCC) [38004193]
Visit / Visit
4.6e-01 3.2e-01 9.0e-01 3.7e+00 9.2e-01 3.8e-01 2.8e-01
68.75%/58.25% 58.75%/50.75% 37.50%/19.63% 23.75%/0.75% 39.24%/20.50% 64.94%/55.75% 83.82%/79.64%
Laboratory Visit
OMOP4822461 (Visit) [32036]
Visit / Visit
-5.4e-02 4.5e-01 1.3e+00 3.4e+00 1.3e+00 4.0e-01 2.5e-01
28.75%/29.88% 40.00%/29.88% 25.00%/8.00% 16.25%/0.63% 25.32%/8.63% 44.16%/34.65% 64.71%/58.88%
Supplier / Service Provider
OMOP5117446 (Visit) [33004]
Visit / Visit
-2.9e-01 — — — — 3.2e+00 2.8e+00
18.75%/23.50% —/— —/— —/— —/— 14.29%/0.64% 17.65%/1.23%
Neurology
13 (Medicare Specialty) [38004458]
Physician Specialty / Provider
7.4e-01 1.7e+00 2.7e+00 1.0e+50 2.6e+00 2.4e+00 1.1e+00
21.25%/11.38% 25.00%/5.63% 8.75%/0.63% 28.75%/0.00% 13.92%/1.13% 29.87%/3.84% 27.94%/11.20%
Examination of eyes and vision
Z01.0 (ICD10) [45566391]
ICD10 code / Procedure
1.5e+00 2.7e+00 — — — — 1.3e+00
6.25%/1.50% 8.75%/0.63% —/— —/— —/— —/— 11.76%/3.55%
Extensive MRI examination of brain with high intensity magnet
AA1CG (NCSPfi) [2001300116]
NCSPfi Level 3 / Procedure
— — — — — — 2.6e+00
—/— —/— —/— —/— —/— —/— 8.82%/0.68%
Optical coherence tomography (OCT) of ocular fundus
CK2X4 (NCSPfi) [2001301456]
NCSPfi Level 2 / Procedure
— — — 1.0e+50 — 1.0e+50 2.6e+00
—/— —/— —/— 6.25%/0.00% —/— 9.09%/0.00% 13.24%/1.09%

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
12
33
4.09
3.47
1.2
1.2
—
—
—
0
0
10
23
4.81
3.44
1.3
1.1
—
—
—
0
0
16
62
2.98
3.28
2.2
2.2
0.21
0.20
g/l
0.10
16
54
5
5
10.54
3.02
1.2
1.0
—
—
—
0
0
48
324
2.20
2.93
7.1
4.7
35.66
34.93
g/l
0.48
42
312
20
101
2.31
2.42
6.4
6.3
7.40
7.41
ph
0.18
11
61
24
134
2.13
2.28
3.4
2.4
2.25
2.27
g/l
0.05
24
122
37
250
1.89
2.04
4.8
4.4
7.40
7.40
ph
0.02
28
170
18
95
2.15
1.95
5.6
3.3
1.75
1.65
%
0.19
18
83
47
348
1.85
1.90
34.0
15.0
1.43
1.28
inr
0.86
42
286
22
127
2.01
1.89
3.6
2.4
23.33
21.95
%
0.13
22
118
24
144
1.95
1.85
4.0
2.3
12.13
12.81
umol/l
0.16
24
131
44
322
1.81
1.82
6.2
3.8
6.30
6.22
ph
0.18
22
170
35
239
1.83
1.82
1.9
1.7
18.03
19.87
nmol/l
0.41
29
188
15
76
2.20
1.78
7.2
7.1
—
—
—
0
0
6
18
3.51
1.78
1.0
1.2
—
—
—
0
0
13
62
2.31
1.77
1.9
1.5
—
—
—
0
0
24
147
1.90
1.74
2.1
1.7
1094.44
1262.73
nmol/l
0.32
16
107
25
157
1.86
1.67
3.2
3.0
2.45
2.47
mmol/l
0.31
19
142
45
339
1.75
1.63
2.6
2.1
92.42
93.98
pmol/l
0.09
31
155
35
246
1.75
1.61
5.9
4.0
15.78
7.35
mg/mmol
0.30
25
157
34
241
1.71
1.50
5.4
3.2
76.20
42.01
mg/l
0.26
25
157
44
336
1.69
1.47
9.0
6.3
2.83
2.76
%
0.09
44
315
44
336
1.69
1.47
5.0
3.0
—
—
estimate
—
0
0
17
98
1.93
1.45
9.2
5.9
1.08
1.06
mmol/l
0.10
17
90
11
54
2.20
1.40
5.5
3.9
—
—
—
0
0
40
301
1.66
1.39
5.4
4.4
37.85
36.79
ng/l
0.02
34
222
75
681
2.62
1.38
28.1
17.7
25.02
25.23
mg/l
0.02
65
573
20
124
1.82
1.37
6.9
5.8
103.05
104.15
mmol/l
0.41
20
124
44
340
1.65
1.37
9.0
6.5
8.76
8.80
%
0.04
44
318
12
63
2.06
1.31
1.2
2.2
—
—
—
0
0
44
343
1.63
1.31
9.2
6.2
59.47
58.03
%
0.39
44
325
50
403
1.64
1.29
7.1
4.1
0.00
0.00
estimate
-0.00
11
94
44
344
1.62
1.28
9.5
6.5
26.05
26.89
%
0.21
44
326
46
364
1.62
1.27
8.4
6.0
0.57
0.59
e9/l
0.12
40
311
6
25
2.51
1.27
1.7
2.1
1.12
1.19
g/l
—
6
25
6
25
2.51
1.27
1.7
2.0
0.23
0.24
g/l
—
6
25
8
37
2.29
1.25
5.5
4.4
36.85
36.91
°c
—
8
37
47
376
1.61
1.23
8.7
5.9
1.86
1.79
e9/l
0.26
42
334
50
406
1.62
1.23
7.2
4.1
0.00
0.00
estimate
—
10
88
43
337
1.60
1.22
9.2
6.3
0.72
0.68
%
0.19
43
313
37
280
1.60
1.22
6.9
3.1
24.18
45.76
e6/l
0.72
26
202
33
243
1.61
1.21
5.0
2.6
—
—
—
0
0
46
368
1.59
1.19
8.4
6.0
0.04
0.04
e9/l
0.12
40
315
33
245
1.59
1.17
5.1
3.0
0.08
0.33
e6/l
1.88
22
169
49
400
1.58
1.15
7.2
4.1
0.00
0.00
estimate
-0.00
11
92
23
157
1.65
1.13
7.3
4.5
1.02
1.02
kg/l
0.74
15
102
75
695
2.26
1.11
23.1
15.9
—
—
—
0
0
9
47
2.03
1.06
1.8
1.6
—
—
—
0
0
5
22
2.35
1.05
1.2
1.2
—
—
—
0
0
32
241
1.55
1.04
8.2
5.8
—
—
—
0
0
51
427
1.54
1.01
12.0
9.5
3.97
4.32
e9/l
0.70
45
368
46
378
1.51
0.99
8.8
6.1
0.20
0.19
e9/l
0.11
41
328
30
226
1.52
0.97
3.4
2.8
60.67
56.14
u/l
0.43
30
206
12
71
1.81
0.95
3.4
3.3
72.41
68.11
e9/l
—
7
52
38
304
1.48
0.91
8.7
3.8
15.27
95.53
e6/l
1.82
26
207
37
296
1.47
0.88
7.5
4.3
0.00
0.00
estimate
-0.00
11
79
30
232
1.47
0.84
5.6
3.0
—
—
estimate
—
0
0
39
328
1.37
0.65
15.2
12.2
0.00
0.00
e9/l
0.50
30
267
5
29
1.77
0.65
1.2
1.2
—
—
—
0
0
46
400
1.35
0.61
8.1
6.8
10.83
11.95
umol/l
0.45
46
376
8
53
1.57
0.60
2.9
2.5
0.74
0.68
%
—
8
53
8
54
1.53
0.59
2.9
2.6
1.30
1.14
%
—
8
54
68
632
1.51
0.58
5.4
4.6
1.34
1.26
mmol/l
0.48
61
570
15
108
1.48
0.58
1.6
1.1
—
—
—
0
0
27
218
1.36
0.57
9.2
3.7
0.00
0.00
estimate
—
8
76
11
75
1.54
0.54
2.1
1.6
—
—
—
0
0
27
221
1.33
0.52
7.1
6.3
—
—
—
0
0
10
68
1.54
0.49
2.6
4.5
1.25
1.23
mmol/l
—
10
59
8
55
1.50
0.45
4.6
4.7
26.26
25.17
mmol/l
—
8
55
5
31
1.65
0.44
1.4
1.4
—
—
—
0
0
0
17
0.00
0.41
0.0
1.5
—
0.93
—
0
17
71
680
1.39
0.38
7.1
6.2
2.43
2.64
mmol/l
1.35
64
618
27
232
1.25
0.35
5.1
4.9
—
—
—
0
0
14
111
1.32
0.33
2.4
1.7
—
—
—
0
0
11
84
1.36
0.32
1.7
1.4
—
—
—
0
0
7
54
1.32
0.31
1.1
1.7
—
—
—
0
0
10
77
1.34
0.27
2.3
1.7
—
—
—
0
0
69
663
1.30
0.27
6.4
5.4
6.35
5.99
mmol/l
0.61
61
603
19
162
1.23
0.26
7.0
5.0
—
—
—
0
0
19
163
1.22
0.24
1.6
1.2
0.40
1.07
u/ml
—
5
47
28
252
1.17
0.22
5.3
3.3
—
—
—
0
0
0
12
0.00
0.21
0.0
2.2
—
—
—
0
0
23
257
0.85
0.21
4.9
3.6
—
—
—
0
0
6
49
1.24
0.20
1.2
1.3
—
—
—
0
0
11
90
1.26
0.20
2.5
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
6
50
1.22
0.20
1.3
1.1
—
—
—
0
0
17
194
0.84
0.19
1.3
1.4
—
—
—
0
0
17
152
1.15
0.13
1.9
1.4
1.48
2.94
g/l
—
9
82
68
663
1.17
0.13
6.4
5.3
1.40
1.45
mmol/l
0.59
62
601
6
71
0.83
0.08
12.2
3.8
—
—
—
0
0
6
73
0.81
0.08
1.2
1.3
—
—
—
0
0
8
73
1.11
0.08
3.9
2.0
248.25
415.10
nmol/l
—
8
67
29
276
1.08
0.07
3.1
2.2
—
—
—
0
0
25
237
1.08
0.06
8.3
4.0
0.00
0.00
estimate
—
9
82
18
169
1.08
0.05
2.8
1.8
321.31
442.35
pmol/l
1.30
13
141
63
639
0.93
0.03
7.1
5.3
2.04
1.97
mu/l
0.17
58
571
28
289
0.95
0.03
2.2
1.9
1.42
1.30
mmol/l
0.29
23
223
11
106
1.04
0.00
2.6
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
3.0
—
5.53
—
0
7
0
8
0.00
0.00
0.0
2.3
—
31.85
—
0
8
0
5
0.00
0.00
0.0
1.4
—
8.48
—
0
5
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
3.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
8
87
0.91
-0.00
3.4
1.4
—
—
—
0
0
10
100
1.00
-0.00
1.3
1.3
—
—
—
0
0
7
73
0.96
-0.00
1.7
2.4
3.97
4.18
e9/l
—
7
64
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint H7_RETARTOCCTRANS and mortality.

Females

Parameter HR [95% CI] p-value
H7_RETARTOCCTRANS 1.193 [0.88, 1.61] 0.248
Birth year 0.994 [0.99, 1.0] 0.183

During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 215 females with H7_RETARTOCCTRANS died.

Males

Parameter HR [95% CI] p-value
H7_RETARTOCCTRANS 1.48 [1.11, 1.98] 0.008
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 82 out of 228 males with H7_RETARTOCCTRANS died.

Mortality risk

Mortality risk for people of age

years, who have H7_RETARTOCCTRANS.

N-year risk Females Males
1 0.125% 0.28%
5 0.736% 1.675%
10 1.684% 4.116%
15 3.186% 7.73%
20 5.643% 12.837%

Relationships between endpoints

↥

Index endpoint: H7_RETARTOCCTRANS – Transient retinal artery occlusion

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data