Transient retinal artery occlusion

H7_RETARTOCCTRANS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H34.0
  • Cause of death: ICD-10 H34.0

2 out of 7 registries used, show all original rules.

77

4. Check minimum number of events

None

77

5. Include endpoints

None

77

6. Filter based on genotype QC (FinnGen only)

77

Control definitions (FinnGen only)

Control exclude
H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H34
Name in latin
Occlusio arteriae retinalis transitoria

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 494 232 259
Only index persons 457 219 238
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 69.25 71.14 67.63
Only index persons 68.72 70.55 67.03

-FinnGen-

Key figures

All Female Male
Number of individuals 77 39 38
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 64.91 63.60 66.26

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
71
Matched controls
709
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H34.0
ICD-10 Finland
Transient retinal artery occlusion
+∞
102.0
71
*
H34.2
ICD-10 Finland
Other retinal artery occlusions
+∞
18.5
17
*
H34.8
ICD-10 Finland
Other retinal vascular occlusions
+∞
18.5
17
*
H34.1
ICD-10 Finland
Central retinal artery occlusion
+∞
15.1
14
*
CKC12
NOMESCO Finland
Photocoagulation of retina
+∞
11.8
11
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
15.5
10.5
17
14
XCD20
NOMESCO Finland
Photoangiography of eye
+∞
9.6
9
*
XCK10
NOMESCO Finland
Photography of fundus of eye
7.8
9.5
23
41
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
18.9
9.5
14
9
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
101.5
8.6
9
*
AA1AD
NOMESCO Finland
CT of head and brain
4.8
8.2
33
109
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.9
7.0
25
71
XCK00
NOMESCO Finland
Perimetry
7.9
6.8
15
23
C10AA05
ATC
atorvastatin; oral
3.7
6.6
44
217
H53.1
ICD-10 Finland
Subjective visual disturbances
9.1
6.5
13
17

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
12
34
4.00
3.94
5.5
6.8
—
—
—
0
0
43
264
2.42
3.54
21.7
9.7
1.3
1.2
inr
0.33
11
98
11
32
3.84
3.48
1.2
1.2
—
—
—
0
0
45
288
2.35
3.30
6.6
4.2
35.7
34.9
g/l
0.47
38
278
9
21
4.71
3.10
1.2
1.1
—
—
—
0
0
5
5
10.56
3.02
1.0
1.0
—
—
—
0
0
8
20
4.34
2.65
3.0
2.9
—
—
—
0
0
17
77
2.55
2.61
5.6
3.3
1.8
1.6
%
0.29
17
67
14
60
2.63
2.38
7.1
7.1
—
—
—
0
0
6
13
4.90
2.32
1.0
1.0
—
—
—
0
0
13
55
2.64
2.26
1.9
2.1
0.2
0.2
g/l
0.20
13
47
20
106
2.20
2.16
3.4
2.2
2.2
2.3
g/l
0.30
20
95
12
50
2.66
2.15
1.6
1.5
—
—
—
0
0
45
323
1.95
2.11
6.8
4.0
0.0
0.0
estimate
—
8
69
12
51
2.60
2.07
3.1
3.5
72.4
67.5
e9/l
—
7
39
32
206
1.95
2.06
4.6
4.3
7.4
7.4
ph
—
5
42
39
269
1.91
2.04
5.2
4.0
39.4
37.4
ng/l
0.04
32
198
23
133
2.04
1.99
7.1
4.6
1.0
1.0
kg/l
—
6
15
38
263
1.88
1.94
2.5
1.9
93.4
92.1
pmol/l
0.06
26
121
27
167
1.95
1.93
1.6
1.5
18.0
20.1
nmol/l
0.39
22
137
45
332
1.86
1.86
7.0
4.1
0.0
0.0
estimate
—
8
67
29
186
1.90
1.86
4.8
3.0
103.2
40.8
mg/l
0.37
19
122
23
138
1.95
1.78
2.0
1.8
1183.6
1301.9
nmol/l
0.19
14
101
44
328
1.80
1.71
9.6
5.5
0.0
0.0
estimate
—
8
70
55
441
1.87
1.65
7.3
4.5
—
—
—
0
0
30
201
1.81
1.65
5.5
3.9
20.6
6.2
mg/mmol
0.40
19
130
0
42
0.00
1.58
0.0
1.7
—
—
—
0
0
39
286
1.74
1.56
8.4
5.6
2.8
2.7
%
0.08
39
268
5
15
3.49
1.55
2.0
1.7
—
—
—
0
0
33
233
1.73
1.49
6.8
2.8
21.9
63.3
e6/l
1.04
24
165
39
289
1.71
1.48
8.5
6.0
8.8
8.4
%
0.41
39
271
71
636
2.49
1.46
26.6
15.2
24.0
24.4
mg/l
0.04
62
513
38
281
1.70
1.44
8.6
5.5
0.8
0.7
%
0.70
38
261
56
461
1.79
1.43
5.4
3.9
—
—
—
0
0
35
254
1.69
1.42
8.1
3.4
16.4
82.3
e6/l
2.33
25
173
29
200
1.72
1.41
7.7
5.0
—
—
—
0
0
11
54
2.21
1.41
5.5
3.9
—
—
—
0
0
39
292
1.68
1.40
8.6
5.6
58.9
57.5
%
0.35
39
275
29
201
1.71
1.38
5.1
2.4
—
—
—
0
0
13
69
2.06
1.38
4.8
3.6
—
—
—
0
0
39
296
1.64
1.31
8.9
5.8
26.6
27.2
%
0.14
39
277
30
213
1.67
1.30
5.0
2.7
0.1
0.4
e6/l
1.83
21
145
10
50
2.15
1.23
1.2
1.9
—
—
—
0
0
23
154
1.70
1.23
3.0
3.9
—
—
—
0
0
47
380
1.61
1.18
11.7
8.6
4.0
4.4
e9/l
0.74
42
332
8
40
2.11
1.16
2.9
2.6
1.3
1.2
%
—
8
40
8
41
2.06
1.12
1.9
1.6
—
—
—
0
0
7
32
2.30
1.11
6.0
4.3
—
—
—
0
0
72
661
2.37
1.11
22.3
14.2
—
—
—
0
0
5
21
2.47
1.11
1.6
1.9
0.2
0.2
g/l
—
5
21
20
134
1.67
1.05
3.7
3.0
2.5
2.5
mmol/l
0.25
15
119
5
22
2.36
1.05
1.6
1.9
1.1
1.2
g/l
—
5
22
9
49
1.95
1.03
1.9
1.2
—
—
—
0
0
29
222
1.49
0.86
5.1
3.1
2.4
2.3
mmol/l
0.84
24
194
27
206
1.48
0.81
5.6
2.7
—
—
—
0
0
26
197
1.48
0.81
3.2
2.7
61.5
54.0
u/l
0.74
26
182
13
84
1.66
0.78
1.4
1.2
—
—
—
0
0
7
43
1.69
0.69
1.0
1.2
—
58.3
—
0
5
71
665
1.87
0.67
30.4
18.0
81.5
80.6
umol/l
0.08
71
665
13
88
1.57
0.66
11.1
5.1
1.1
1.0
mmol/l
0.37
13
82
24
186
1.42
0.65
9.7
3.7
—
—
—
0
0
10
65
1.62
0.59
2.1
1.6
—
—
—
0
0
68
636
1.59
0.58
5.9
5.2
2.4
2.7
mmol/l
1.97
62
575
57
518
1.39
0.55
33.9
18.5
14.0
13.8
%
0.52
57
508
64
593
1.47
0.55
4.9
4.2
1.3
1.3
mmol/l
0.22
59
536
6
40
1.54
0.53
1.2
1.1
—
—
—
0
0
17
129
1.41
0.51
1.6
1.2
0.4
1.1
u/ml
—
5
39
7
47
1.54
0.49
3.1
2.5
—
—
—
0
0
66
620
1.45
0.47
5.4
4.7
6.5
6.0
mmol/l
0.63
59
562
26
215
1.32
0.47
5.4
3.2
—
—
—
0
0
24
198
1.31
0.44
5.3
4.7
—
—
—
0
0
10
71
1.47
0.41
1.7
1.3
—
—
—
0
0
33
286
1.27
0.41
14.2
9.8
0.0
0.0
e9/l
0.74
26
233
5
36
1.42
0.39
1.0
1.3
—
—
—
0
0
6
44
1.39
0.35
1.2
1.7
—
—
—
0
0
6
44
1.39
0.35
4.8
4.2
27.7
25.1
mmol/l
—
6
44
7
54
1.33
0.31
1.4
1.5
—
—
—
0
0
12
94
1.33
0.30
2.5
1.7
—
—
—
0
0
8
65
1.26
0.28
2.6
1.8
—
—
—
0
0
20
171
1.23
0.27
8.8
6.4
—
—
—
0
0
11
88
1.29
0.24
2.5
1.9
—
—
—
0
0
5
42
1.20
0.22
4.6
4.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
2.9
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
23
204
1.18
0.21
5.1
4.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
14
119
1.22
0.19
1.9
1.4
1.4
3.0
g/l
—
7
66
5
67
0.73
0.17
14.4
3.6
—
—
—
0
0
8
72
1.12
0.16
3.0
1.6
—
—
—
0
0
9
82
1.11
0.15
1.3
1.3
—
—
—
0
0
25
231
1.12
0.13
3.0
2.1
—
—
—
0
0
17
153
1.14
0.12
6.9
4.7
—
—
—
0
0
59
575
1.11
0.09
30.7
15.3
37.9
39.9
%
0.67
41
392
6
53
1.14
0.09
14.5
4.5
—
—
—
0
0
8
75
1.07
0.08
3.3
1.4
—
—
—
0
0
20
189
1.08
0.05
9.2
4.1
0.0
0.0
estimate
—
8
66
16
169
0.93
0.03
1.3
1.4
—
—
—
0
0
22
228
0.95
0.02
4.0
3.1
—
—
—
0
0
16
153
1.06
0.01
2.7
1.7
359.0
436.7
pmol/l
0.53
11
131
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
2.7
—
5.5
—
0
7
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
6
60
1.00
0.00
4.7
1.9
267.5
404.8
nmol/l
—
6
54
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
6.2
—
0
5

Mortality – FinRegistry

Association

Association between endpoint H7_RETARTOCCTRANS and mortality.

Females

Parameter HR [95% CI] p-value
H7_RETARTOCCTRANS 1.193 [0.88, 1.61] 0.248
Birth year 0.994 [0.99, 1.0] 0.183

During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 215 females with H7_RETARTOCCTRANS died.

Males

Parameter HR [95% CI] p-value
H7_RETARTOCCTRANS 1.48 [1.11, 1.98] 0.008
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 82 out of 228 males with H7_RETARTOCCTRANS died.

Mortality risk

Mortality risk for people of age

years, who have H7_RETARTOCCTRANS.

N-year risk Females Males
1 0.125% 0.28%
5 0.736% 1.675%
10 1.684% 4.116%
15 3.186% 7.73%
20 5.643% 12.837%

Relationships between endpoints

Index endpoint: H7_RETARTOCCTRANS – Transient retinal artery occlusion

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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