Cicatricial pemphigoid

L12_PEMPHIGOID_CICA

mucous membrane pemphigoid: Mucous membrane pemphigoid is a bullous dermatosis characterised clinically by blistering of the mucous membranes followed by scarring, and immunologically by IgG, IgA and/or C3 deposits on the epidermal basement membrane.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L12.1 Cause of death: ICD-10 — L12.1 2 out of 7 registries used, show all original rules.	70
4. Check minimum number of events None	70
5. Include endpoints None	70
6. Filter based on genotype QC (FinnGen only)	70

Control definitions (FinnGen only)

Control exclude: L12_BULLOUS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L12
Name in latin: Pemphigoides cicatricalis

NAME	L12_PEMPHIGOID_CICA
CONTROL_EXCLUDE	L12_BULLOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L121
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L121
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Cicatricial pemphigoid based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	410	265	143
Only index persons	375	247	128
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	68.93	68.40	69.73
Only index persons	67.68	66.93	69.13

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	70	50	20
Unadjusted period prevalence (%)	0.01	0.02	0.01
Median age at first event (years)	64.21	61.81	70.22

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
64: Matched controls
641

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L12.1

ICD-10 Finland

Cicatricial pemphigoid

+∞

91.9

L12.0

ICD-10 Finland

Bullous pemphigoid

+∞

38.5

ECA20

NOMESCO Finland

Biopsy of gingiva

142.2

19.8

J04BA02

ATC

dapsone; oral

+∞

15.2

L12.9

ICD-10 Finland

Pemphigoid, unspecified

+∞

15.2

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

12.2

14.3

D07AD01

ATC

clobetasol; topical

9.4

13.7

H02AB06

ATC

prednisolone; systemic

9.8

13.6

227

L04AX01

ATC

azathioprine; systemic

16.5

12.4

L12.8

ICD-10 Finland

Other pemphigoid

+∞

10.7

SBB00

NOMESCO Finland

Fotograf of mouth and teeth

19.1

10.1

D07AC01

ATC

betamethasone; topical

5.8

10.1

158

EKA10

NOMESCO Finland

Biopsy of cheek

36.2

9.8

135

Kela drug reimbursment

Pemphigus

+∞

8.5

K13.79

ICD-10 Finland

Change in the oral mucosa UNS

20.6

8.4

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

3.7

6.0

188

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

71.41

24.54

2.6

1.3

20.9

—

u/ml

—

(3037522) Nuclear Ab [Titer] in Serum

5.10

8.82

1.2

1.4

370.0

416.0

titre

—

(42870298) TPMT gene c.238G>C+460G>A+719A>G [Identifier] in Blood or Tissue by Molecular genetics method Narrative

+∞

7.41

1.0

0.0

—

(42870588) Differential panel, method unspecified - Blood

185

3.71

6.82

11.3

4.3

—

(3026389) Candida sp identified in Specimen by Organism specific culture

16.91

6.08

1.8

1.0

—

(40768443) Skin Pathology biopsy report

5.83

5.99

1.2

1.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

112

3.30

5.21

6.5

5.6

—

(3021589) Normoblasts [#/volume] in Blood

261

3.03

4.72

12.4

9.8

0.0

e9/l

0.50

210

(3002030) Lymphocytes/100 leukocytes in Blood

268

2.73

3.95

12.6

5.4

31.0

27.7

0.90

245

(3022096) Basophils/100 leukocytes in Blood

259

2.71

3.95

12.3

5.1

0.8

0.6

1.25

236

(3004588) Protein electrophoresis panel - Serum or Plasma

3.76

3.85

1.7

3.9

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

4.50

3.84

1.3

2.9

—

(3006504) Eosinophils/100 leukocytes in Blood

265

2.61

3.68

12.5

5.3

3.1

2.6

0.73

244

(3019069) Monocytes/100 leukocytes in Blood

268

2.57

3.56

12.9

5.5

9.2

8.2

1.30

247

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

5.27

3.37

1.2

3.5

0.0

g/l

—

(3018010) Neutrophils/100 leukocytes in Blood

266

2.45

3.26

12.4

5.2

54.9

57.7

0.68

246

(3021960) Folate [Moles/volume] in Serum or Plasma

149

2.47

3.17

1.9

1.6

17.4

23.7

nmol/l

1.20

119

(3035350) Ketones [Presence] in Urine by Test strip

288

2.42

3.13

5.0

4.1

0.0

estimate

—

(3045424) Erythrocytes [Presence] in Urine

8.06

3.12

1.3

1.5

—

(3009261) Glucose [Presence] in Urine by Test strip

293

2.35

2.94

5.0

4.1

0.0

estimate

—

(3029937) Albumin [Presence] in Urine by Test strip

162

2.35

2.91

5.8

4.0

0.0

estimate

—

(3020961) Endomysium IgA Ab [Titer] in Serum

4.33

2.89

1.0

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

117

2.44

2.83

1.6

1.2

1.3

u/ml

—

(40768804) Tissue Pathology biopsy report

241

2.26

2.81

2.6

2.3

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

8.84

2.79

1.6

4.2

49.4

55.2

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

8.84

2.79

1.6

1.7

2.9

4.6

e9/l

—

(40758558) Short blood count panel - Blood

165

2.29

2.77

15.2

6.3

—

(3000494) Fungus identified in Specimen by Culture

2.71

2.73

1.4

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

4.73

2.54

1.7

1.3

—

(3037467) Urinalysis macro (dipstick) panel - Urine

409

2.40

2.46

5.4

4.4

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

4.45

2.43

2.1

1.2

1.0

1.2

g/l

—

(3021601) Nitrite [Presence] in Urine by Test strip

289

2.13

2.41

6.2

5.6

0.0

estimate

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

252

2.11

2.40

2.6

2.0

91.3

99.7

pmol/l

0.51

124

(3024561) Albumin [Mass/volume] in Serum or Plasma

262

2.10

2.37

5.1

4.0

34.5

35.3

g/l

0.38

246

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

2.43

2.24

12.6

8.8

—

(3045414) Leukocytes [Presence] in Urine

3.97

2.21

1.4

2.1

—

(40761535) Cells panel - Urine sediment

2.69

2.16

6.6

3.0

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

130

2.15

2.16

6.6

3.9

—

(3044889) 12 lead EKG panel

401

2.15

2.07

3.8

3.9

—

(3026008) Bacteria identified in Urine by Culture

192

1.98

2.00

2.5

3.3

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

570

2.96

1.88

4.7

5.3

2.8

2.7

mmol/l

0.37

511

(3018418) pH of Serum or Plasma

187

1.94

1.87

2.8

4.6

7.4

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

279

1.90

1.84

4.6

5.9

1.2

mmol/l

0.03

248

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

263

1.86

1.75

2.5

2.2

75.3

76.0

nmol/l

0.07

223

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

4.05

1.74

1.4

1.2

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

301

1.77

1.50

4.4

6.4

1.2

mmol/l

0.26

253

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

361

1.80

1.48

3.7

2.8

48.2

45.7

u/l

0.10

335

(3015377) Calcium [Moles/volume] in Serum or Plasma

217

1.77

1.48

3.5

3.3

2.4

mmol/l

1.00

188

(3001122) Ferritin [Mass/volume] in Serum or Plasma

254

1.76

1.48

2.7

2.5

242.5

112.1

ug/l

1.03

228

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

558

2.29

1.41

4.4

4.8

4.7

mmol/l

0.54

506

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.75

1.40

1.8

1.7

—

(3007164) IgA [Mass/volume] in Serum or Plasma

109

1.88

1.35

1.9

1.3

3.7

2.3

g/l

0.93

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.52

1.34

1.5

1.8

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

430

1.81

1.33

4.8

4.0

14.9

pmol/l

0.01

384

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.64

1.33

2.0

1.8

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

536

2.07

1.30

20.2

15.1

74.0

75.7

ml/min/173m2

0.24

440

(3003458) Phosphate [Moles/volume] in Serum or Plasma

1.97

1.28

3.4

4.4

1.0

1.1

mmol/l

0.59

(40768797) Stomach Pathology biopsy report

1.92

1.27

1.2

—

(4010399)

2.24

1.23

1.4

1.3

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

554

2.04

1.21

4.3

4.8

1.6

1.5

mmol/l

0.81

495

(3031040) Bacteria [#/volume] in Urine by Automated count

404

1.71

1.21

5.7

4.8

—

949.7

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

2.61

1.17

1.0

1.3

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

540

2.01

1.17

3.9

4.2

1.2

mmol/l

0.07

481

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

230

1.62

1.14

5.9

4.1

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

519

1.87

1.07

5.9

4.9

1.8

1.9

mu/l

0.20

457

(40761536) Microorganisms panel - Urine sediment

2.05

1.07

2.2

3.7

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

216

1.58

1.03

3.1

2.9

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

541

1.76

0.85

7.3

6.1

40.3

40.2

mmol/mol

0.03

498

(40768793) Breast Pathology biopsy report

0.00

0.79

0.0

1.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

489

1.58

0.78

23.8

15.7

37.5

39.4

0.85

342

(3022313) Gas panel - Capillary blood

2.26

0.78

7.0

3.9

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.75

0.73

2.6

3.7

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

103

1.58

0.72

2.1

1.3

—

(3032080) INR in Blood by Coagulation assay

243

1.41

0.66

7.6

6.7

1.3

inr

—

(3012544) pH of Venous blood

1.54

0.60

1.9

3.9

—

(4035726)

1.57

0.57

1.3

1.4

—

(3002256) Pathology report gross observation

1.60

0.56

1.3

1.2

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

102

1.47

0.52

1.3

23.3

46.6

iu/ml

—

(3012516) Albumin [Mass/volume] in Urine

175

1.38

0.52

4.9

3.0

66.8

43.1

mg/l

0.23

108

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.62

0.51

1.3

1.5

—

(36660697) Celiac disease serology panel - Serum

1.62

0.51

1.6

1.2

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

178

1.34

0.46

2.2

2.3

51.1

58.0

u/l

0.46

168

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.60

0.43

4.6

2.6

1.0

0.7

—

(3020682) Albumin/Creatinine [Ratio] in Urine

190

1.31

0.42

6.0

3.7

11.1

8.1

mg/mmol

0.16

112

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

0.00

0.42

0.0

1.5

—

(3006184) Hemoglobin [Mass/volume] in Capillary blood

0.00

0.41

0.0

2.1

—

127.7

—

(3009343) pH of Capillary blood

1.51

0.41

8.8

3.4

—

7.4

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

1.40

0.41

1.1

1.3

1.9

10.5

u/ml

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.40

0.0

4.6

—

35.1

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.40

0.0

3.4

—

53.3

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.40

0.35

2.3

1.1

—

(3018095) Leukocytes [#/volume] in Urine

216

1.24

0.32

3.2

3.7

55.9

73.0

e6/l

0.15

147

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

265

1.23

0.31

3.2

3.7

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.33

0.30

2.2

1.8

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

1.33

0.30

2.3

2.5

1.0

0.9

e6/l

—

(3019225) pH of Specimen

1.35

0.29

7.4

3.9

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.35

0.29

1.3

1.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.30

0.29

1.8

1.7

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.33

0.26

1.2

1.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

319

1.19

0.25

1.9

2.8

—

(3025941) Bacteria identified in Stool by Culture

1.38

0.24

1.0

1.2

—

(21494755) Public health laboratory ask at order entry panel

1.38

0.24

1.8

1.4

—

(3026782) Osmolality of Urine

124

0.77

0.24

2.3

2.8

494.0

560.4

mosm/kgh2o

—

104

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.30

0.23

1.4

1.3

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.30

0.23

1.0

1.4

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.21

0.0

1.9

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.8

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.2

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.21

0.0

1.2

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.21

0.0

1.8

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.21

0.0

1.3

—

128.8

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.21

0.0

2.6

—

1.5

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

4.7

—

137.1

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.8

—

(40767503) Oxygen content in Capillary blood by calculation

0.00

0.21

0.0

2.7

—

15.9

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.20

0.0

1.9

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.21

0.18

1.9

1.5

—

(3019309) Folate [Moles/volume] in Red Blood Cells

121

1.20

0.16

2.1

1.6

982.8

1159.6

nmol/l

—

(3022145) Colonoscopy Study observation

1.13

0.16

1.1

1.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

132

1.17

0.14

1.9

2.4

—

(3002582) Erythrocytes [#/volume] in Urine

187

0.88

0.12

2.9

3.1

96.8

71.8

e6/l

0.13

141

(3000492) Spirometry study

1.18

0.10

1.6

1.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

165

1.12

0.10

3.2

3.7

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.12

0.09

1.3

1.4

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.06

0.09

3.0

3.2

23.3

31.4

u/l

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.11

0.08

1.4

1.5

—

(3013512) EKG study

197

1.09

0.07

5.5

4.4

—

(3042936) Bacteria identified in Isolate by Culture

1.04

0.07

1.7

—

(1761868) Lipid panel - Serum or Plasma

178

1.09

0.06

3.6

3.2

—

(3030467) Casts [#/volume] in Urine by Automated count

170

1.08

0.04

2.9

3.0

0.7

0.5

e6/l

0.10

126

(3023368) Bacteria identified in Blood by Culture

181

1.07

0.03

5.3

3.6

—

(3044640) Blood type and Crossmatch panel - Blood

189

1.01

0.00

2.2

2.3

—

(36304419) Bacteria [Presence] in Urine

165

0.96

0.00

2.9

—

(3003694) ABO and Rh group [Type] in Blood

141

0.99

0.00

1.4

1.3

—

(3045716) Anion gap in Serum or Plasma

0.00

0.0

2.2

—

5.8

—

(44790048)

0.00

0.0

1.4

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.0

1.4

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

2.8

—

88.2

—

(4306422)

0.00

0.0

1.4

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

2.7

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.3

—

355.4

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.0

1.3

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.1

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

2.0

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

1.1

—

31.9

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

13.5

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.2

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

1.6

—

(44790049)

0.00

0.0

1.4

—

(44806118)

0.00

0.0

1.4

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.0

3.0

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.0

1.6

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

3.0

—

(3044941) Cell count panel - Synovial fluid

0.00

0.0

1.9

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.0

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.1

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.1

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.02

0.00

1.4

1.3

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.0

1.6

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

251.0

—

(3006270) Folate [Moles/volume] in Blood

0.00

0.0

1.1

—

402.4

—

(3027008) Opiates [Presence] in Urine

0.00

0.0

1.4

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.0

1.4

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

1.3

—

107.0

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

3.0

—

(44790047)

0.00

0.0

1.4

—

(3021788) Differential panel - Synovial fluid

0.00

0.0

1.8

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

0.90

0.00

2.0

1.8

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

5.0

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.0

—

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

0.00

0.0

1.5

—

(3001467) Alkaline phosphatase.bone [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.3

—

46.2

—

(3047189) Immunofixation for 24 hour Urine

0.00

0.0

2.0

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.2

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.1

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

0.9

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

1.8

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

1.0

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

5.3

—

(3009991) Angiotensin converting enzyme [Enzymatic activity/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

0.9

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

4.6

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.5

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.0

—

(3011288) Drugs identified in Urine by Screen method

0.00

0.0

2.0

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.0

1.1

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.0

1.3

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

3.9

—

(3040151) Glucose [Moles/volume] in Capillary blood

0.00

0.0

23.6

—

6.4

—

(3016879) Cocaine [Presence] in Urine

0.00

0.0

1.4

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_PEMPHIGOID_CICA and mortality.

Females

Parameter	HR [95% CI]	p-value
L12_PEMPHIGOID_CICA	1.164 [0.85, 1.6]	0.353
Birth year	0.997 [0.99, 1.01]	0.51

During the follow-up period (1.1.1998 — 31.12.2019), 67 out of 250 females with L12_PEMPHIGOID_CICA died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_PEMPHIGOID_CICA.

N-year risk	Females	Males
1	0.123%	No data
5	0.767%	No data
10	1.93%	No data
15	3.849%	No data
20	6.67%	No data

Relationships between endpoints

↥

Index endpoint: L12_PEMPHIGOID_CICA – Cicatricial pemphigoid

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Cicatricial pemphigoid

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints